@inproceedings{BaronasIvanauskasKulys2006,
  author    = {Baronas, Romas and Ivanauskas, Feliksas and Kulys, Juozas},
  title     = {Mathematical modeling of biosensors based on an array of enzyme microreactors},
  url       = {http://nbn-resolving.de/urn:nbn:de:hbz:a96-opus-1569},
  year      = {2006},
  abstract  = {This paper presents a two-dimensional-in-space mathematical model of biosensors based on an array of enzyme microreactors immobilised on a single electrode. The modeling system acts under amperometric conditions. The microreactors were modeled by particles and by strips. The model is based on the diffusion equations containing a nonlinear term related to the Michaelis-Menten kinetics of the enzymatic reaction. The model involves three regions: an array of enzyme microreactors where enzyme reaction as well as mass transport by diffusion takes place, a diffusion limiting region where only the diffusion takes place, and a convective region, where the analyte concentration is maintained constant. Using computer simulation, the influence of the geometry of the microreactors and of the diffusion region on the biosensor response was investigated. The digital simulation was carried out using the finite difference technique.},
  subject      = {Biosensor},
  language  = {en}
}
@inproceedings{LeiMulchandaniChenetal.2006,
  author    = {Lei, Yu and Mulchandani, Priti and Chen, Wilfred and Mulchandani, Ashok},
  title     = {Biosensor for direct determination of fenitrothion and EPN using recombinant Pseudomonas putida JS444 with surface expressed organophosphorus hydrolase. 1. modified clark oxygen electrode},
  url       = {http://nbn-resolving.de/urn:nbn:de:hbz:a96-opus-1573},
  year      = {2006},
  abstract  = {This paper reports a first microbial biosensor for rapid and cost-effective determination of organophosphorus pesticides fenitrothion and EPN. The biosensor consisted of recombinant PNP-degrading/oxidizing bacteria Pseudomonas putida JS444 anchoring and displaying organophosphorus hydrolase (OPH) on its cell surface as biological sensing element and a dissolved oxygen electrode as the transducer. Surfaceexpressed OPH catalyzed the hydrolysis of fenitrothion and EPN to release 3-methyl-4-nitrophenol and p-nitrophenol, respectively, which were oxidized by the enzymatic machinery of Pseudomonas putida JS444 to carbon dioxide while consuming oxygen, which was measured and correlated to the concentration of organophosphates. Under the optimum operating conditions, the biosensor was able to measure as low as 277 ppb of fenitrothion and 1.6 ppm of EPN without interference from phenolic compounds and other commonly used pesticides such as carbamate pesticides, triazine herbicides and organophosphate pesticides without nitrophenyl substituent. The applicability of the biosensor to lake water was also demonstrated.},
  subject      = {Biosensor},
  language  = {en}
}
@inproceedings{NaetherJuarezEmmerichetal.2006,
  author    = {N{\"a}ther, Niko and Ju{\´a}rez, Leon M. and Emmerich, R{\"u}diger and Berger, J{\"o}rg and Friedrich, Peter and Sch{\"o}ning, Michael Josef},
  title     = {Detection of hydrogen peroxide (H2O2) at exposed temperatures for industrial processes},
  url       = {http://nbn-resolving.de/urn:nbn:de:hbz:a96-opus-1418},
  year      = {2006},
  abstract  = {An H2O2 sensor for the application in industrial sterilisation processes has been developed. Therefore, automated sterilisation equipment at laboratory scale has been constructed using parts from industrial sterilisation facilities. In addition, a software tool has been developed for the control of the sterilisation equipment at laboratory scale. First measurements with the developed sensor set-up as part of the sterilisation equipment have been performed and the sensor has been physically characterised by optical microscopy and SEM.},
  subject      = {Biosensor},
  language  = {en}
}
@inproceedings{WagnerKohlFroebaetal.2006,
  author    = {Wagner, Thorsten and Kohl, Claus-Dieter and Fr{\"o}ba, Michael and Tiemann, Michael},
  title     = {Gas sensing properties of ordered mesoporous SnO2},
  url       = {http://nbn-resolving.de/urn:nbn:de:hbz:a96-opus-1422},
  year      = {2006},
  abstract  = {We report on the synthesis and CO gas-sensing properties of mesoporous tin(IV) oxides (SnO2). For the synthesis cetyltrimethylammonium bromide (CTABr) was used as a structure-directing agent; the resulting SnO2 powders were applied as films to commercially available sensor substrates by drop coating. Nitrogen physisorption shows specific surface areas up to 160 m2·g-1 and mean pore diameters of about 4 nm, as verified by TEM. The film conductance was measured in dependence on the CO concentration in humid synthetic air at a constant temperature of 300 °C. The sensors show a high sensitivity at low CO concentrations and turn out to be largely insensitive towards changes in the relative humidity. We compare the materials with commercially available SnO2-based sensors.},
  subject      = {Biosensor},
  language  = {en}
}
@inproceedings{MirmohseniRostamizadeh2006,
  author    = {Mirmohseni, Abdolreza and Rostamizadeh, Kobra},
  title     = {Quartz crystal nanobalance in conjunction with principal component analysis for identification of volatile organic compounds},
  url       = {http://nbn-resolving.de/urn:nbn:de:hbz:a96-opus-1434},
  year      = {2006},
  abstract  = {Quartz crystal nanobalance (QCN) sensors are considered as powerful masssensitive sensors to determine materials in the sub-nanogram level. In this study, a single piezoelectric quartz crystal nanobalance modified with polystyrene was employed to detect benzene, toluene, ethylbenzene and xylene (BTEX compounds). The frequency shift of the QCN sensor was found to be linear against the BTEX compound concentrations in the range about 1-45 mg l-1. The correlation coefficients for benzene, toluene, ethylbenzene, and xylene were 0.991, 0.9977, 0.9946 and 0.9971, respectively. The principal component analysis was also utilized to process the frequency response data of the single piezoelectric crystal at different times, considering to the different adsorption-desorption dynamics of BTEX compounds. Using principal component analysis, it was found that over 90\% of the data variance could still be explained by use of two principal components (PC1 and PC2). Subsequently, the successful identification of benzene and toluene was possible through the principal component analysis of the transient responses of the polystyrene modified QCN sensor. The results showed that the polystyrene-modified QCN had favorable identification and quantification performances for the BTEX compounds.},
  subject      = {Biosensor},
  language  = {en}
}
@inproceedings{KreutzLoergenGraeweetal.2006,
  author    = {Kreutz, Christian and L{\"o}rgen, J{\"u}rgen and Graewe, Boris and Bargon, Joachim and Yoshida, Mayumi and Freso, Zachary M. and Fr{\`e}chet, Jean M. J.},
  title     = {High frequency quartz micro balances: a promising path to enhanced sensitivity of gravimetric sensors},
  url       = {http://nbn-resolving.de/urn:nbn:de:hbz:a96-opus-1445},
  year      = {2006},
  abstract  = {An array of 50 MHz quartz microbalances (QMBs) coated with a dendronized polymer was used to detect small amounts of volatile organic compounds (VOCs) in the gas phase. The results were compared to those obtained with the commonly used 10 MHz QMBs. The 50 MHz QMBs proved to be a powerful tool for the detection of VOCs in the gas phase; therefore, they represent a promising alternative to the much more delicate surface acoustic wave devices (SAWs).},
  subject      = {Biosensor},
  language  = {en}
}
@inproceedings{RabnerShacham2006,
  author    = {Rabner, Arthur and Shacham, Yosi},
  title     = {A concept for a sensitive micro total analysis system for high throughput fluorescence imaging},
  url       = {http://nbn-resolving.de/urn:nbn:de:hbz:a96-opus-1456},
  year      = {2006},
  abstract  = {This paper discusses possible methods for on-chip fluorescent imaging for integrated bio-sensors. The integration of optical and electro-optical accessories, according to suggested methods, can improve the performance of fluorescence imaging. It can boost the signal to background ratio by a few orders of magnitudes in comparison to conventional discrete setups. The methods that are present in this paper are oriented towards building reproducible arrays for high-throughput micro total analysis systems (µTAS). The first method relates to side illumination of the fluorescent material placed into microcompartments of the lab-on-chip. Its significance is in high utilization of excitation energy for low concentration of fluorescent material. The utilization of a transparent µLED chip, for the second method, allows the placement of the excitation light sources on the same optical axis with emission detector, such that the excitation and emission rays are directed controversly. The third method presents a spatial filtering of the excitation background.},
  subject      = {Biosensor},
  language  = {en}
}
@inproceedings{FoersterStockMontanarietal.2006,
  author    = {F{\"o}rster, Arnold and Stock, J{\"u}rgen and Montanari, Simone and Lepsa, Mihail Ion and L{\"u}th, Hans},
  title     = {Fabrication and characterisation of GaAs Gunn Diode Chips for applications at 77 GHz in automotive industry},
  url       = {http://nbn-resolving.de/urn:nbn:de:hbz:a96-opus-1462},
  year      = {2006},
  abstract  = {GaAs-based Gunn diodes with graded AlGaAs hot electron injector heterostructures have been developed under the special needs in automotive applications. The fabrication of the Gunn diode chips was based on total substrate removal and processing of integrated Au heat sinks. Especially, the thermal and RF behavior of the diodes have been analyzed by DC, impedance and S-parameter measurements. The electrical investigations have revealed the functionality of the hot electron injector. An optimized layer structure could fulfill the requirements in adaptive cruise control (ACC) systems at 77 GHz with typical output power between 50 and 90 mW.},
  subject      = {Biosensor},
  language  = {en}
}
@inproceedings{PlatenPoghossianSchoening2006,
  author    = {Platen, Johannes and Poghossian, Arshak and Sch{\"o}ning, Michael Josef},
  title     = {Microstructured Nanostructures - nanostructuring by means of conventional photolithography and layer-expansion technique},
  url       = {http://nbn-resolving.de/urn:nbn:de:hbz:a96-opus-1477},
  year      = {2006},
  abstract  = {A new and simple method for nanostructuring using conventional photolithography and layer expansion or pattern-size reduction technique is presented, which can further be applied for the fabrication of different nanostructures and nano-devices. The method is based on the conversion of a photolithographically patterned metal layer to a metal-oxide mask with improved pattern-size resolution using thermal oxidation. With this technique, the pattern size can be scaled down to several nanometer dimensions. The proposed method is experimentally demonstrated by preparing nanostructures with different configurations and layouts, like circles, rectangles, trapezoids, "fluidic-channel"-, "cantilever"- and meander-type structures.},
  subject      = {Biosensor},
  language  = {en}
}
@inproceedings{PijanowskaRemiszewskaPederzollietal.2006,
  author    = {Pijanowska, Dorota G. and Remiszewska, Elzbieta and Pederzolli, Cecilia and Lunelli, Lorenzo and Vendano, Michele and Canteri, Roberto and Dudzinski, Konrad and Kruk, Jerzy and Torbicz, Wladyslaw},
  title     = {Surface modification for microreactor fabrication},
  url       = {http://nbn-resolving.de/urn:nbn:de:hbz:a96-opus-1480},
  year      = {2006},
  abstract  = {In this paper, methods of surface modification of different supports, i.e. glass and polymeric beads for enzyme immobilisation are described. The developed method of enzyme immobilisation is based on Schiff's base formation between the amino groups on the enzyme surface and the aldehyde groups on the chemically modified surface of the supports. The surface of silicon modified by APTS and GOPS with immobilised enzyme was characterised by atomic force microscopy (AFM), time-of-flight secondary ion mass spectroscopy (ToF-SIMS) and infrared spectroscopy (FTIR). The supports with immobilised enzyme (urease) were also tested in combination with microreactors fabricated in silicon and Perspex, operating in a flow-through system. For microreactors filled with urease immobilised on glass beads (Sigma) and on polymeric beads (PAN), a very high and stable signal (pH change) was obtained. The developed method of urease immobilisation can be stated to be very effective.},
  subject      = {Biosensor},
  language  = {en}
}