@article{WuBronderPoghossianetal.2014,
  author    = {Wu, Chunsheng and Bronder, Thomas and Poghossian, Arshak and Werner, Frederik and B{\"a}cker, Matthias and Sch{\"o}ning, Michael Josef},
  title     = {Label-free electrical detection of DNA with a multi-spot LAPS: First step towards light-addressable DNA chips},
  series = {Physica status solidi A : Applications and materials science},
  volume    = {211},
  journal   = {Physica status solidi A : Applications and materials science},
  number    = {6},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1521-396X (E-Journal); 1862-6319 (E-Journal); 0031-8965 (Print); 1862-6300 (Print)},
  doi       = {10.1002/pssa.201330442},
  pages     = {1423 -- 1428},
  year      = {2014},
  abstract  = {A multi-spot (4 × 4 spots) light-addressable potentiometric sensor (MLAPS) consisting of an Al-p-Si-SiO2 structure has been applied for the label-free electrical detection of DNA (deoxyribonucleic acid) immobilization and hybridization by the intrinsic molecular charge for the first time. Single-stranded probe ssDNA molecules (20 bases) were covalently immobilized onto the silanized SiO2 gate surface. The unspecific adsorption of mismatch ssDNA on the MLAPS gate surface was blocked by bovine serum albumin molecules. To reduce the screening effect and to achieve a high sensor signal, the measurements were performed in a low ionic-strength solution. The photocurrent-voltage (I-V) curves were simultaneously recorded on all 16 spots after each surface functionalization step. Large shifts of I-V curves of 25 mV were registered after the DNA immobilization and hybridization event. In contrast, a small potential shift (∼5 mV) was observed in case of mismatch ssDNA, revealing good specificity of the sensor. The obtained results demonstrate the potential of the MLAPS as promising transducer platform for the multi-spot label-free electrical detection of DNA molecules by their intrinsic molecular charge.},
  language  = {en}
}
@article{SalpatiChuChenetal.2014,
  author    = {Salpati, Laurent and Chu, Xiaoyan and Chen, Liangfu and Prasad, Bhagwat and Dallas, Shannon and Evers, Raymond and Mamaril-Fishman, Donna and Geier, Ethan G. and Kehler, Jonathan and Kunta, Jeevan and Mezler, Mario and Laplanche, Loic and Pang, Jodie and Soars, Matthew G. and Unadkat, Jashvant D. and van Waterschoot, Robert A.B. and Yabut, Jocelyn and Schinkel, Alfred H. and Scheer, Nico and Rode, Anja},
  title     = {Evaluation of organic anion transporting polypeptide 1B1 and 1B3 humanized mice as a translational model to study the pharmacokinetics of statins},
  series = {Drug Metabolism and Disposition},
  volume    = {42},
  journal   = {Drug Metabolism and Disposition},
  number    = {8},
  publisher = {ASPET},
  address   = {Bethesda, Md.},
  issn      = {1521-009X},
  doi       = {10.1124/dmd.114.057976},
  pages     = {1301 -- 1313},
  year      = {2014},
  abstract  = {Organic anion transporting polypeptide (Oatp) 1a/1b knockout and OATP1B1 and -1B3 humanized mouse models are promising tools for studying the roles of these transporters in drug disposition. Detailed characterization of these models will help to better understand their utility for predicting clinical outcomes. To advance this approach, we carried out a comprehensive analysis of these mouse lines by evaluating the compensatory changes in mRNA expression, quantifying the amounts of OATP1B1 and -1B3 protein by liquid chromatography-tandem mass spectrometry, and studying the active uptake in isolated hepatocytes and the pharmacokinetics of some prototypical substrates including statins. Major outcomes from these studies were 1) mostly moderate compensatory changes in only a few genes involved in drug metabolism and disposition, 2) a robust hepatic expression of OATP1B1 and -1B3 proteins in the respective humanized mouse models, and 3) functional activities of the human transporters in hepatocytes isolated from the humanized models with several substrates tested in vitro and with pravastatin in vivo. However, the expression of OATP1B1 and -1B3 in the humanized models did not significantly alter liver or plasma concentrations of rosuvastatin and pitavastatin compared with Oatp1a/1b knockout controls under the conditions used in our studies. Hence, although the humanized OATP1B1 and -1B3 mice showed in vitro and/or in vivo functional activity with some statins, further characterization of these models is required to define their potential use and limitations in the prediction of drug disposition and drug-drug interactions in humans.},
  language  = {en}
}
@article{FeichtingerEilmannBuchmannetal.2014,
  author    = {Feichtinger, Linda M. and Eilmann, Britta and Buchmann, Nina and Rigling, Andreas},
  title     = {Growth adjustments of conifers to drought and to century-long irrigation},
  series = {Forest Ecology and Management},
  volume    = {2014},
  journal   = {Forest Ecology and Management},
  number    = {334},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1872-7042 (Online)},
  doi       = {10.1016/j.foreco.2014.08.008},
  pages     = {96 -- 105},
  year      = {2014},
  abstract  = {Our knowledge on tree responses to drought is mainly based on short-term manipulation experiments which do not capture any possible long-term adjustments in this response. Therefore, historical water channels in inner-Alpine dry valleys were used as century-long irrigation experiments to investigate adjustments in tree growth to contrasting water supply. This involved quantifying the tree-ring growth of irrigated and non-irrigated (control) Scots pine (Pinus sylvestris L.) in Valais (Switzerland), as well as European larch (Larix decidua Mill.) and black pine (Pinus nigra Arnold) in Vinschgau (Italy). Furthermore, the adjustments in radial growth of Scots pine and European larch to an abrupt stop in irrigation were analyzed. Irrigation promoted the radial growth of all tree species investigated compared to the control: (1) directly through increased soil water availability, and (2) indirectly through increased soil nutrients and humus contents in the irrigated plots. Irrigation led to a full elimination of growth responses to climate for European larch and black pine, but not for Scots pine, which might become more sensitive to drought with increasing tree size in Valais. For the control trees, the response of the latewood increment to water availability in July/August has decreased in recent decades for all species, but increased in May for Scots pine only. The sudden irrigation stop caused a drop in radial growth to a lower level for Scots pine or similar level for larch compared to the control for up to ten years. However, both tree species were then able to adjust to the new conditions and subsequently grew with similar (Scots pine) or even higher growth rates (larch) than the control. To estimate the impact of climate change on future forest development, the duration of manipulation experiments should be on longer time scales in order to capture adjustment processes and feedback mechanisms of forest ecosystems.},
  language  = {en}
}
@article{RitzPisarczykSachtlebenetal.2014,
  author    = {Ritz, Thomas and Pisarczyk, Rafael and Sachtleben, Johanna and Leßenich, Nina},
  title     = {Usability Engineering maßgeschneidert : Modellbaukasten zur Entwicklung gebrauchstauglicher mobiler Software},
  series = {Wissenschaft trifft Praxis},
  volume    = {1},
  journal   = {Wissenschaft trifft Praxis},
  number    = {1},
  publisher = {Begleitforschung Mittelstand-Digital c/o WIK-Consult GmbH},
  address   = {Bad Honnef},
  issn      = {2198-8544 (Print)},
  pages     = {79 -- 88},
  year      = {2014},
  language  = {de}
}
@article{WallenbornRitz2014,
  author    = {Wallenborn, Ramona and Ritz, Thomas},
  title     = {Mobilit{\"a}t miteinander teilen : st{\"a}dtisches eCarsharing in einer vernetzten Gesellschaft ; [vernetztes Fahren von morgen]},
  series = {Neue Mobilit{\"a}t : das Magazin vom Bundesverband eMobilit{\"a}t},
  volume    = {5},
  journal   = {Neue Mobilit{\"a}t : das Magazin vom Bundesverband eMobilit{\"a}t},
  number    = {14 (Herbstausg.)},
  publisher = {Bundesverband eMobilit{\"a}t BEM},
  address   = {Berlin},
  issn      = {2191-5636},
  pages     = {92 -- 95},
  year      = {2014},
  language  = {de}
}
@article{FredebeulKreinSteingroever2014,
  author    = {Fredebeul-Krein, Markus and Steingr{\"o}ver, Markus},
  title     = {Wholesale broadband access to IPTV in an NGA environment : how to deal with it from a regulatory perspective?},
  series = {Telecommunications Policy},
  volume    = {38},
  journal   = {Telecommunications Policy},
  number    = {3},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0308-5961 (Print)},
  doi       = {doi:10.1016/j.telpol.2013.04.002},
  pages     = {264 -- 277},
  year      = {2014},
  language  = {en}
}
@article{Sillius2014,
  author    = {Sillius, Sarah},
  title     = {„Viele machen gutes Marketing, ohne es zu wissen" : zwei Experten von FH [Prof. Dr. Gert Hoepner] und RWTH Aachen [Prof. Dr. Daniel Mentzel] erkl{\"a}ren, wie Unternehmen ihre Zielgruppe besser erreichen},
  series = {Wirtschaftliche Nachrichten : das Magazin f{\"u}r Unternehmen / Industrie- und Handelskammer Aachen},
  volume    = {2014},
  journal   = {Wirtschaftliche Nachrichten : das Magazin f{\"u}r Unternehmen / Industrie- und Handelskammer Aachen},
  number    = {3},
  publisher = {IHK Aachen},
  address   = {Aachen},
  pages     = {16 -- 18},
  year      = {2014},
  language  = {de}
}
@article{EilmannSterckWegneretal.2014,
  author    = {Eilmann, Britta and Sterck, Frank J. and Wegner, L. and de Vries, Sven M. G. and von Arx, G. and Mohren, Godefridus M. J. and den Ouden, Jan and Sass-Klaassen, Ute G. W.},
  title     = {Wood structural differences between northern and southern beech provenances growing at a moderate site},
  series = {Tree Physiology},
  volume    = {34},
  journal   = {Tree Physiology},
  number    = {8},
  publisher = {Oxford University Press},
  address   = {Oxford},
  issn      = {1758-4469 (Online)},
  doi       = {10.1093/treephys/tpu069},
  pages     = {882 -- 893},
  year      = {2014},
  language  = {en}
}
@article{Stulpe2014,
  author    = {Stulpe, Werner},
  title     = {From the attempt of certain classical reformulations of quantum mechanics to quasi-probability representations},
  series = {Journal of Mathematical Physics},
  volume    = {55},
  journal   = {Journal of Mathematical Physics},
  number    = {1},
  publisher = {AIP Publishing},
  address   = {College Park, Md.},
  issn      = {222-488},
  doi       = {10.1063/1.4861939},
  pages     = {Artikel 012109},
  year      = {2014},
  abstract  = {The concept of an injective affine embedding of the quantum states into a set of classical states, i.e., into the set of the probability measures on some measurable space, as well as its relation to statistically complete observables is revisited, and its limitation in view of a classical reformulation of the statistical scheme of quantum mechanics is discussed. In particular, on the basis of a theorem concerning a non-denseness property of a set of coexistent effects, it is shown that an injective classical embedding of the quantum states cannot be supplemented by an at least approximate classical description of the quantum mechanical effects. As an alternative approach, the concept of quasi-probability representations of quantum mechanics is considered.},
  language  = {en}
}
@article{AlKaidyDuweHusteretal.2014,
  author    = {Al-Kaidy, Huschyar and Duwe, Anna and Huster, Manuel and Muffler, Kai and Schlegel, Christin and Sieker, Tim and Stadtm{\"u}ller, Ralf and Tippk{\"o}tter, Nils and Ulber, Roland},
  title     = {Biotechnologie und Bioverfahrenstechnik - Vom ersten Ullmanns Artikel bis hin zu aktuellen Forschungsthemen},
  series = {Chemie Ingenieur Technik},
  volume    = {86},
  journal   = {Chemie Ingenieur Technik},
  number    = {12},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {0009-286X},
  doi       = {10.1002/cite.201400083},
  pages     = {2215 -- 2225},
  year      = {2014},
  abstract  = {Biotechnologie und die mit ihr verbundenen technischen Prozesse pr{\"a}gen seit Jahrtausenden die Entwicklung der Menschheit. Ausgehend von empirischen Verfahren, insbesondere zur Herstellung von Lebensmitteln und t{\"a}glichen Gebrauchsg{\"u}tern, haben sich diese Disziplinen zu einem der innovativsten Zukunftsfelder entwickelt. Durch das immer detailliertere Verst{\"a}ndnis zellul{\"a}rer Vorg{\"a}nge k{\"o}nnen mittlerweile Produktionsst{\"a}mme gezielt optimiert werden. Im Zusammenspiel mit moderner Prozesstechnik k{\"o}nnen so eine Vielzahl von Bulk- und Feinchemikalien sowie Pharmazeutika effizient hergestellt werden. In diesem Artikel werden exemplarisch einige der aktuellen Trends vorgestellt.},
  language  = {de}
}