@incollection{Fabo2022, author = {Fabo, Sabine}, title = {Pandemische Momente}, series = {Interaktion - Emotion - Desinfektion ; Kunst und Museum in Zeiten von Corona / Birgit Richard, Jana M{\"u}ller, Niklas von Reischach (Hrsg.)}, booktitle = {Interaktion - Emotion - Desinfektion ; Kunst und Museum in Zeiten von Corona / Birgit Richard, Jana M{\"u}ller, Niklas von Reischach (Hrsg.)}, publisher = {Campus}, address = {Frankfurt ; New York}, isbn = {978-3-593-51520-5 (Print)}, pages = {137 -- 140}, year = {2022}, language = {de} } @book{KurzSchwer2022, author = {Kurz, Melanie and Schwer, Thilo}, title = {Geschichte des Designs}, edition = {1. Auflage}, publisher = {Beck}, address = {M{\"u}nchen}, isbn = {978-3-406-78813-0}, pages = {128 Seiten}, year = {2022}, abstract = {Dieser Band bietet einen kompakten {\"U}berblick {\"u}ber die wichtigsten Stationen des Produktdesigns vom Beginn der Industrialisierung bis heute. Im Zentrum stehen ikonische Alltagsgegenst{\"a}nde vom Thonet-Stuhl bis zum iPhone. Anschaulich und kenntnisreich nehmen Melanie Kurz und Thilo Schwer dabei auch die gesellschaftspolitische Situation, in der die Objekte entstanden sind, in den Blick.}, language = {de} } @incollection{Fabo2022, author = {Fabo, Sabine}, title = {Pl{\"u}schviren - Zur Konstruktion von N{\"a}he in Zeiten der Pandemie}, series = {Interaktion - Emotion - Desinfektion ; Kunst und Museum in Zeiten von Corona / Birgit Richard, Jana M{\"u}ller, Niklas von Reischach (Hrsg.)}, booktitle = {Interaktion - Emotion - Desinfektion ; Kunst und Museum in Zeiten von Corona / Birgit Richard, Jana M{\"u}ller, Niklas von Reischach (Hrsg.)}, publisher = {Campus}, address = {Frankfurt ; New York}, isbn = {978-3-593-51520-5 (Print)}, pages = {45 -- 69}, year = {2022}, language = {de} } @phdthesis{Biewendt2022, author = {Biewendt, Marcel}, title = {Socio-Economic challenges in sustainability and resource management}, publisher = {Hungarian University of Agriculture and Life Sciences}, pages = {160 Seiten}, year = {2022}, abstract = {This dissertation uses in first stage a macroeconomic investigation to examine the dependence, influence and corruption of socio-economic development through effects of sustainability and resource management. The conducted research found that the state's dependence on its citizens decreases when the state's sources of revenue are largely detached and independent of the citizens' financial resources. In this case, financial resources are taxes and duties provided by the citizens. One possible consequence is the restriction of state investment in its citizens. Both the qualitative literature review and the quantitative data analysis revealed a negative correlation between socio-economic development and the resource economy's share of GDP for the period under study. The microeconomic investigation was primarily conducted through an intensive literature review. It was shown that the rebound effect as such is already very well researched. However, it also became clear that avoidance strategies for the rebound effect and links to sustainability initiatives are scarce or non-existent. The need for a redesign of the impact analysis with regard to technological innovations and their influence on resource consumption and resource management has become clear on the basis of the present study. Further, emerging and developing countries in particular, which will be confronted in the foreseeable future not only with the fundamental problems of resource abundance in the overall economic context, but also with the issues of their sustainable use, should be confronted with these problems as early as possible in order to find solutions in a timely manner.}, language = {de} } @article{UysalCreutzFiratetal.2022, author = {Uysal, Karya and Creutz, Till and Firat, Ipek Seda and Artmann, Gerhard and Teusch, Nicole and Temiz Artmann, Ayseg{\"u}l}, title = {Bio-functionalized ultra-thin, large-area and waterproof silicone membranes for biomechanical cellular loading and compliance experiments}, series = {Polymers}, volume = {14}, journal = {Polymers}, number = {11}, publisher = {MDPI}, address = {Basel}, issn = {2073-4360}, pages = {2213}, year = {2022}, abstract = {Biocompatibility, flexibility and durability make polydimethylsiloxane (PDMS) membranes top candidates in biomedical applications. CellDrum technology uses large area, <10 µm thin membranes as mechanical stress sensors of thin cell layers. For this to be successful, the properties (thickness, temperature, dust, wrinkles, etc.) must be precisely controlled. The following parameters of membrane fabrication by means of the Floating-on-Water (FoW) method were investigated: (1) PDMS volume, (2) ambient temperature, (3) membrane deflection and (4) membrane mechanical compliance. Significant differences were found between all PDMS volumes and thicknesses tested (p < 0.01). They also differed from the calculated values. At room temperatures between 22 and 26 °C, significant differences in average thickness values were found, as well as a continuous decrease in thicknesses within a 4 °C temperature elevation. No correlation was found between the membrane thickness groups (between 3-4 µm) in terms of deflection and compliance. We successfully present a fabrication method for thin bio-functionalized membranes in conjunction with a four-step quality management system. The results highlight the importance of tight regulation of production parameters through quality control. The use of membranes described here could also become the basis for material testing on thin, viscous layers such as polymers, dyes and adhesives, which goes far beyond biological applications.}, language = {en} } @article{UysalFiratCreutzetal.2022, author = {Uysal, Karya and Firat, Ipek Serat and Creutz, Till and Aydin, Inci Cansu and Artmann, Gerhard and Teusch, Nicole and Temiz Artmann, Ayseg{\"u}l}, title = {A novel in vitro wound healing assay using free-standing, ultra-thin PDMS membranes}, series = {membranes}, volume = {2023}, journal = {membranes}, number = {13(1)}, publisher = {MDPI}, address = {Basel}, doi = {10.3390/membranes13010022}, pages = {Artikel 22}, year = {2022}, abstract = {Advances in polymer science have significantly increased polymer applications in life sciences. We report the use of free-standing, ultra-thin polydimethylsiloxane (PDMS) membranes, called CellDrum, as cell culture substrates for an in vitro wound model. Dermal fibroblast monolayers from 28- and 88-year-old donors were cultured on CellDrums. By using stainless steel balls, circular cell-free areas were created in the cell layer (wounding). Sinusoidal strain of 1 Hz, 5\% strain, was applied to membranes for 30 min in 4 sessions. The gap circumference and closure rate of un-stretched samples (controls) and stretched samples were monitored over 4 days to investigate the effects of donor age and mechanical strain on wound closure. A significant decrease in gap circumference and an increase in gap closure rate were observed in trained samples from younger donors and control samples from older donors. In contrast, a significant decrease in gap closure rate and an increase in wound circumference were observed in the trained samples from older donors. Through these results, we propose the model of a cell monolayer on stretchable CellDrums as a practical tool for wound healing research. The combination of biomechanical cell loading in conjunction with analyses such as gene/protein expression seems promising beyond the scope published here.}, language = {en} } @inproceedings{WeissHeslenfeldSaeweetal.2022, author = {Weiss, Christian and Heslenfeld, Jonas and Saewe, Jasmin Kathrin and Bremen, Sebastian and H{\"a}fner, Constantin Leon}, title = {Investigation on the influence of powder humidity in Laser Powder Bed Fusion (LPBF)}, series = {Procedia CIRP 12th CIRP Conference on Photonic Technologies [LANE 2022]}, volume = {111}, booktitle = {Procedia CIRP 12th CIRP Conference on Photonic Technologies [LANE 2022]}, publisher = {Elsevier}, address = {Amsterdam}, issn = {2212-8271}, doi = {10.1016/j.procir.2022.08.102}, pages = {115 -- 120}, year = {2022}, abstract = {In the Laser Powder Bed Fusion (LPBF) process, parts are built out of metal powder material by exposure of a laser beam. During handling operations of the powder material, several influencing factors can affect the properties of the powder material and therefore directly influence the processability during manufacturing. Contamination by moisture due to handling operations is one of the most critical aspects of powder quality. In order to investigate the influences of powder humidity on LPBF processing, four materials (AlSi10Mg, Ti6Al4V, 316L and IN718) are chosen for this study. The powder material is artificially humidified, subsequently characterized, manufactured into cubic samples in a miniaturized process chamber and analyzed for their relative density. The results indicate that the processability and reproducibility of parts made of AlSi10Mg and Ti6Al4V are susceptible to humidity, while IN718 and 316L are barely influenced.}, language = {en} } @article{AngermannGuenthnerHanssenetal.2022, author = {Angermann, Susanne and G{\"u}nthner, Roman and Hanssen, Henner and Lorenz, Georg and Braunisch, Matthias C. and Steubl, Dominik and Matschkal, Julia and Kemmner, Stephan and Hausinger, Renate and Block, Zenonas and Haller, Bernhard and Heemann, Uwe and Kotliar, Konstantin and Grimmer, Timo and Schmaderer, Christoph}, title = {Cognitive impairment and microvascular function in end-stage renal disease}, series = {International Journal of Methods in Psychiatric Research (MPR)}, volume = {31}, journal = {International Journal of Methods in Psychiatric Research (MPR)}, number = {2}, publisher = {Wiley}, issn = {1049-8931 (Print)}, doi = {10.1002/mpr.1909}, pages = {1 -- 10}, year = {2022}, abstract = {Objective Hemodialysis patients show an approximately threefold higher prevalence of cognitive impairment compared to the age-matched general population. Impaired microcirculatory function is one of the assumed causes. Dynamic retinal vessel analysis is a quantitative method for measuring neurovascular coupling and microvascular endothelial function. We hypothesize that cognitive impairment is associated with altered microcirculation of retinal vessels. Methods 152 chronic hemodialysis patients underwent cognitive testing using the Montreal Cognitive Assessment. Retinal microcirculation was assessed by Dynamic Retinal Vessel Analysis, which carries out an examination recording retinal vessels' reaction to a flicker light stimulus under standardized conditions. Results In unadjusted as well as in adjusted linear regression analyses a significant association between the visuospatial executive function domain score of the Montreal Cognitive Assessment and the maximum arteriolar dilation as response of retinal arterioles to the flicker light stimulation was obtained. Conclusion This is the first study determining retinal microvascular function as surrogate for cerebral microvascular function and cognition in hemodialysis patients. The relationship between impairment in executive function and reduced arteriolar reaction to flicker light stimulation supports the involvement of cerebral small vessel disease as contributing factor for the development of cognitive impairment in this patient population and might be a target for noninvasive disease monitoring and therapeutic intervention.}, language = {en} } @article{KotliarOrtnerConradietal.2022, author = {Kotliar, Konstantin and Ortner, Marion and Conradi, Anna and Hacker, Patricia and Hauser, Christine and G{\"u}nthner, Roman and Moser, Michaela and Muggenthaler, Claudia and Diehl-Schmid, Janine and Priller, Josef and Schmaderer, Christoph and Grimmer, Timo}, title = {Altered retinal cerebral vessel oscillation frequencies in Alzheimer's disease compatible with impaired amyloid clearance}, series = {Neurobiology of Aging}, volume = {120}, journal = {Neurobiology of Aging}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0197-4580}, doi = {10.1016/j.neurobiolaging.2022.08.012}, pages = {117 -- 127}, year = {2022}, abstract = {Retinal vessels are similar to cerebral vessels in their structure and function. Moderately low oscillation frequencies of around 0.1 Hz have been reported as the driving force for paravascular drainage in gray matter in mice and are known as the frequencies of lymphatic vessels in humans. We aimed to elucidate whether retinal vessel oscillations are altered in Alzheimer's disease (AD) at the stage of dementia or mild cognitive impairment (MCI). Seventeen patients with mild-to-moderate dementia due to AD (ADD); 23 patients with MCI due to AD, and 18 cognitively healthy controls (HC) were examined using Dynamic Retinal Vessel Analyzer. Oscillatory temporal changes of retinal vessel diameters were evaluated using mathematical signal analysis. Especially at moderately low frequencies around 0.1 Hz, arterial oscillations in ADD and MCI significantly prevailed over HC oscillations and correlated with disease severity. The pronounced retinal arterial vasomotion at moderately low frequencies in the ADD and MCI groups would be compatible with the view of a compensatory upregulation of paravascular drainage in AD and strengthen the amyloid clearance hypothesis.}, language = {en} } @incollection{MoorkampPetersonUibel2022, author = {Moorkamp, Wilfried and Peterson, Leif Arne and Uibel, Thomas}, title = {Nachhaltige Holzbr{\"u}cken f{\"u}r Geh- und Radwege}, series = {Bauphysik Kalender 2022: Holzbau, 22. Jahrgang}, booktitle = {Bauphysik Kalender 2022: Holzbau, 22. Jahrgang}, editor = {Fouad, Nabil A.}, publisher = {Ernst \& Sohn}, address = {Berlin}, isbn = {9783433033609 (Print)}, doi = {10.1002/9783433611081.ch17}, pages = {574 -- 592}, year = {2022}, abstract = {Am Lehr- und Forschungsgebiet Holzbau der Fachhochschule Aachen wurden im Rahmen des Forschungsvorhabens „Nachhaltige Standardbr{\"u}cken in Holzbauweise" Standardtypen f{\"u}r Geh- und Radwegbr{\"u}cken entwickelt. Die Br{\"u}cken sind durch konsequente Umsetzungen von Maßnahmen des konstruktiven Holzschutzes f{\"u}r eine Nutzung von mehr als 80~Jahren konzipiert. Innovative L{\"o}sungen f{\"u}r Bauteile und Anschl{\"u}sse sowie Materialalternativen im Bereich des Belages und der Gel{\"a}nder erm{\"o}glichen eine wartungsarme Konstruktion und tragen somit zur Wirtschaftlichkeit und Nachhaltigkeit bei. Um den Einsatz der entwickelten Standardbr{\"u}ckentypen in der Praxis zu erleichtern, wurden Leistungsverzeichnisse, Musterstatiken, Musterzeichnungen und umfangreiche Detailkataloge als Unterst{\"u}tzung f{\"u}r Planer und Bauherren erstellt. Damit die Randbedingungen f{\"u}r eine lange Lebensdauer w{\"a}hrend der Nutzung der Br{\"u}cke erhalten bleiben, wurden Leitf{\"a}den f{\"u}r die Pflege und Wartung sowie f{\"u}r die Br{\"u}ckenpr{\"u}fung erarbeitet. Der Beitrag gibt Einblicke in das Forschungsvorhaben und seine Resultate.}, language = {de} }