@inproceedings{FrotscherRaatschenStaat2012, author = {Frotscher, Ralf and Raatschen, Hans-J{\"u}rgen and Staat, Manfred}, title = {Effectiveness of the edge-based smoothed finite element method applied to soft biological tissues}, series = {ESMC-2012 - 8th European Solid Mechanics Conference, Graz, Austria, July 9-13, 2012}, booktitle = {ESMC-2012 - 8th European Solid Mechanics Conference, Graz, Austria, July 9-13, 2012}, editor = {Holzapfel, Gerhard A.}, publisher = {Verlag d. Technischen Universit{\"a}t Graz}, address = {Graz}, isbn = {978-3-85125-223-1}, year = {2012}, language = {en} } @article{BassamHeschelerTemizArtmannetal.2012, author = {Bassam, Rasha and Hescheler, J{\"u}rgen and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard and Digel, Ilya}, title = {Effects of spermine NONOate and ATP on the thermal stability of hemoglobin}, series = {BMC Biophysics}, volume = {5}, journal = {BMC Biophysics}, publisher = {BioMed Central}, address = {London}, issn = {2046-1682}, doi = {10.1186/2046-1682-5-16}, pages = {Art. 16}, year = {2012}, abstract = {Background Minor changes in protein structure induced by small organic and inorganic molecules can result in significant metabolic effects. The effects can be even more profound if the molecular players are chemically active and present in the cell in considerable amounts. The aim of our study was to investigate effects of a nitric oxide donor (spermine NONOate), ATP and sodium/potassium environment on the dynamics of thermal unfolding of human hemoglobin (Hb). The effect of these molecules was examined by means of circular dichroism spectrometry (CD) in the temperature range between 25°C and 70°C. The alpha-helical content of buffered hemoglobin samples (0.1 mg/ml) was estimated via ellipticity change measurements at a heating rate of 1°C/min. Results Major results were: 1) spermine NONOate persistently decreased the hemoglobin unfolding temperature T u irrespectively of the Na + /K + environment, 2) ATP instead increased the unfolding temperature by 3°C in both sodium-based and potassium-based buffers and 3) mutual effects of ATP and NO were strongly influenced by particular buffer ionic compositions. Moreover, the presence of potassium facilitated a partial unfolding of alpha-helical structures even at room temperature. Conclusion The obtained data might shed more light on molecular mechanisms and biophysics involved in the regulation of protein activity by small solutes in the cell.}, language = {en} } @inproceedings{WeilPoghossianSchoeningetal.2012, author = {Weil, M. and Poghossian, Arshak and Sch{\"o}ning, Michael Josef and Cherstvy, A.}, title = {Electrical monitoring of layer-by-layer adsorption of oppositely charged macromolecules by means of capacitive field-effect devices}, isbn = {978-3-9813484-2-2}, doi = {10.5162/IMCS2012/P2.5.2}, pages = {1575 -- 1578}, year = {2012}, language = {en} } @phdthesis{Oflaz2012, author = {Oflaz, Hakan}, title = {Entwicklung eines Prototypen zur Prognose von Fr{\"u}hgeburten : ein biomedizintechnischer Ansatz}, publisher = {Deutsche Zentralbibliothek f{\"u}r Medizin}, address = {K{\"o}ln}, doi = {10.4126/38m-004639208}, year = {2012}, language = {en} } @inproceedings{PhamNguyenStaat2012, author = {Pham, Phu Tinh and Nguyen, Thanh Ngoc and Staat, Manfred}, title = {FEM based shakedown analysis of hardening structures}, series = {Proceedings International Conference on Advances in Computational Mechanics (ACOME)}, booktitle = {Proceedings International Conference on Advances in Computational Mechanics (ACOME)}, pages = {870 -- 882}, year = {2012}, language = {en} } @article{PoghossianWeilBaeckeretal.2012, author = {Poghossian, Arshak and Weil, M. H. and B{\"a}cker, Matthias and Mayer, D. and Sch{\"o}ning, Michael Josef}, title = {Field-effect Devices Functionalised with Gold-Nanoparticle/Macromolecule Hybrids: New Opportunities for a Label-Free Biosensing}, series = {Procedia Engineering}, journal = {Procedia Engineering}, number = {47}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1877-7058}, doi = {10.1016/j.proeng.2012.09.136}, pages = {273 -- 276}, year = {2012}, abstract = {Field-effect capacitive electrolyte-insulator-semiconductor (EIS) sensors functionalised with citrate-capped gold nanoparticles (AuNP) have been used for the electrostatic detection of macromolecules by their intrinsic molecular charge. The EIS sensor detects the charge changes in the AuNP/macromolecule hybrids induced by the adsorption or binding events. A feasibility of the proposed detection scheme has been exemplary demonstrated by realising EIS sensors for the detection of poly-D-lysine molecules.}, language = {en} } @inproceedings{DuongNguyenStaat2012, author = {Duong, Minh Tuan and Nguyen, Nhu Hunyh and Staat, Manfred}, title = {Finite Element Implementation of a 3D Fung-type Model}, series = {ESMC-2012 - 8th European Solid Mechanics Conference, Graz, Austria, July 9-13, 2012}, booktitle = {ESMC-2012 - 8th European Solid Mechanics Conference, Graz, Austria, July 9-13, 2012}, publisher = {Verlag d. Technischen Universit{\"a}t Graz}, address = {Graz}, isbn = {978-3-85125-223-1}, year = {2012}, language = {en} } @article{NovacekTranKlingeetal.2012, author = {Novacek, V. and Tran, Thanh Ngoc and Klinge, U. and Tolba, R. H. and Staat, Manfred and Bronson, D. G. and Miesse, A. M. and Whiffen, J. and Turquier, F.}, title = {Finite element modelling of stapled colorectal end-to-end anastomosis : Advantages of variable height stapler design}, series = {Journal of Biomechanics}, volume = {45}, journal = {Journal of Biomechanics}, number = {115}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1873-2380}, doi = {10.1016/j.jbiomech.2012.07.021}, pages = {2693 -- 2697}, year = {2012}, abstract = {The impact of surgical staplers on tissues has been studied mostly in an empirical manner. In this paper, finite element method was used to clarify the mechanics of tissue stapling and associated phenomena. Various stapling modalities and several designs of circular staplers were investigated to evaluate the impact of the device on tissues and mechanical performance of the end-to-end colorectal anastomosis. Numerical simulations demonstrated that a single row of staples is not adequate to resist leakage due to non-linear buckling and opening of the tissue layers between two adjacent staples. Compared to the single staple row configuration, significant increase in stress experienced by the tissue at the inner staple rows was observed in two and three rows designs. On the other hand, adding second and/or third staple row had no effect on strain in the tissue inside the staples. Variable height design with higher staples in outer rows significantly reduced the stresses and strains in outer rows when compared to the same configuration with flat cartridge.}, language = {en} } @article{GrinsvenBonStrauvenetal.2012, author = {Grinsven, Bart van and Bon, Natalie vanden and Strauven, Hannelore and Grieten, Lars and Murib, Mohammed and Jim{\´e}nez Monroy, Kathia L. and Janssens, Stoffel D. and Haenen, Ken and Sch{\"o}ning, Michael Josef and Vermeeren, Veronique and Ameloot, Marcel and Michiels, Luc and Thoelen, Ronald and Ceuninck, Ward de and Wagner, Patrick}, title = {Heat-Transfer Resistance at Solid-Liquid Interfaces: A Tool for The Detection of Single Nucleotide Polymorphisms in DNA.}, series = {ACS Nano}, volume = {6}, journal = {ACS Nano}, number = {3}, publisher = {ACS Publications}, address = {Washington, DC}, issn = {1936-086X}, doi = {10.1021/nn300147e}, pages = {2712 -- 2721}, year = {2012}, abstract = {In this article, we report on the heat-transfer resistance at interfaces as a novel, denaturation-based method to detect single-nucleotide polymorphisms in DNA. We observed that a molecular brush of double-stranded DNA grafted onto synthetic diamond surfaces does not notably affect the heat-transfer resistance at the solid-to-liquid interface. In contrast to this, molecular brushes of single-stranded DNA cause, surprisingly, a substantially higher heat-transfer resistance and behave like a thermally insulating layer. This effect can be utilized to identify ds-DNA melting temperatures via the switching from low- to high heat-transfer resistance. The melting temperatures identified with this method for different DNA duplexes (29 base pairs without and with built-in mutations) correlate nicely with data calculated by modeling. The method is fast, label-free (without the need for fluorescent or radioactive markers), allows for repetitive measurements, and can also be extended toward array formats. Reference measurements by confocal fluorescence microscopy and impedance spectroscopy confirm that the switching of heat-transfer resistance upon denaturation is indeed related to the thermal on-chip denaturation of DNA.}, language = {en} } @incollection{DigelMansurovBiisenbaevetal.2012, author = {Digel, Ilya and Mansurov, Zulkhair and Biisenbaev, Makhmut and Savitskaya, Irina and Kistaubaeva, Aida and Akimbekov, Nuraly and Zhubanova, Azhar}, title = {Heterogeneous Composites on the Basis of Microbial Cells and Nanostructured Carbonized Sorbents}, series = {Composites and Their Applications}, booktitle = {Composites and Their Applications}, editor = {Hu, Ning}, publisher = {Intech}, address = {London}, isbn = {978-953-51-0706-4}, doi = {10.5772/47796}, pages = {249 -- 272}, year = {2012}, abstract = {The fact that microorganisms prefer to grow on liquid/solid phase surfaces rather than in the surrounding aqueous phase was noticed long time ago [1]. Virtually any surface - animal, mineral, or vegetable - is a subject for microbial colonization and subsequent biofilm formation. It would be adequate to name just a few notorious examples on microbial colonization of contact lenses, ship hulls, petroleum pipelines, rocks in streams and all kinds of biomedical implants. The propensity of microorganisms to become surface-bound is so profound and ubiquitous that it vindicates the advantages for attached forms over their free-ranging counterparts [2]. Indeed, from ecological and evolutionary standpoints, for many microorganisms the surface-bound state means dwelling in nutritionally favorable, non-hostile environments [3]. Therefore, in most of natural and artificial ecosystems surface-associated microorganisms vastly outnumber organisms in suspension and often organize into complex communities with features that differ dramatically from those of free cells [4].}, language = {en} }