@article{ScheerSnaithWolfetal.2013, author = {Scheer, Nico and Snaith, Mike and Wolf, C. Roland and Seibler, Jost}, title = {Generation and utility of genetically humanized mouse models}, series = {Drug Discovery Today}, volume = {Vol 18}, journal = {Drug Discovery Today}, number = {23-24}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1359-6446}, doi = {10.1016/j.drudis.2013.07.007}, pages = {1200 -- 1211}, year = {2013}, language = {en} } @article{ScheerWilson2016, author = {Scheer, Nico and Wilson, Ian D.}, title = {A comparison between genetically humanized and chimeric liver humanized mouse models for studies in drug metabolism and toxicity}, series = {Drug Discovery Today}, volume = {21}, journal = {Drug Discovery Today}, number = {2}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1359-6446}, doi = {10.1016/j.drudis.2015.09.002}, pages = {250 -- 263}, year = {2016}, abstract = {Mice that have been genetically humanized for proteins involved in drug metabolism and toxicity and mice engrafted with human hepatocytes are emerging and promising in vivo models for an improved prediction of the pharmacokinetic, drug-drug interaction and safety characteristics of compounds in humans. The specific advantages and disadvantages of these models should be carefully considered when using them for studies in drug discovery and development. Here, an overview on the corresponding genetically humanized and chimeric liver humanized mouse models described to date is provided and illustrated with examples of their utility in drug metabolism and toxicity studies. We compare the strength and weaknesses of the two different approaches, give guidance for the selection of the appropriate model for various applications and discuss future trends and perspectives.}, language = {en} } @article{ScheerWolf2014, author = {Scheer, Nico and Wolf, C. Roland}, title = {Genetically humanized mouse models of drug metabolizing enzymes and transporters and their applications}, series = {Xenobiotica}, volume = {44}, journal = {Xenobiotica}, number = {2}, publisher = {Taylor \& Francis}, address = {Abingdon}, issn = {1366-5928}, doi = {10.3109/00498254.2013.815831}, pages = {96 -- 108}, year = {2014}, abstract = {1. Drug metabolizing enzymes and transporters play important roles in the absorption, metabolism, tissue distribution and excretion of various compounds and their metabolites and thus can significantly affect their efficacy and safety. Furthermore, they can be involved in drug-drug interactions which can result in adverse responses, life-threatening toxicity or impaired efficacy. Significant species differences in the interaction of compounds with drug metabolizing enzymes and transporters have been described. 2. In order to overcome the limitation of animal models in accurately predicting human responses, a large variety of mouse models humanized for drug metabolizing enzymes and to a lesser extent drug transporters have been created. 3. This review summarizes the literature describing these mouse models and their key applications in studying the role of drug metabolizing enzymes and transporters in drug bioavailability, tissue distribution, clearance and drug-drug interactions as well as in human metabolite testing and risk assessment. 4. Though such humanized mouse models have certain limitations, there is great potential for their use in basic research and for testing and development of new medicines. These limitations and future potentials will be discussed.}, language = {en} } @article{ScheerWolf2013, author = {Scheer, Nico and Wolf, C. Roland}, title = {Xenobiotic receptor humanized mice and their utility}, series = {Drug Metabolism Reviews}, journal = {Drug Metabolism Reviews}, number = {1}, publisher = {Taylor \& Francis}, address = {London}, issn = {1097-9883}, doi = {10.3109/03602532.2012.738687}, pages = {110 -- 121}, year = {2013}, language = {en} } @masterthesis{Scheffel2023, type = {Bachelor Thesis}, author = {Scheffel, Zeno Samuel}, title = {Identit{\"a}t, Zusammenhalt, Zugeh{\"o}rigkeit : Die Exploration der Gestaltung von Fußballtrikots}, publisher = {FH Aachen}, address = {Aachen}, pages = {95 Seiten}, year = {2023}, abstract = {Das Fußballtrikot - Arbeitsbekleidung, Identifikationsmerkmal, Distinktionsmerkmal? Was ist das Fußballtrikot, was sind seine identit{\"a}tsstiftenden Merkmale und welche Gestaltungsparameter pr{\"a}gen sein heutiges Aussehen? In dieser Publikation wird die Geschichte des Trikots ebenso wie die {\"a}ußeren Einfl{\"u}sse auf sein heutiges Erscheinungsbild dokumentiert und analysiert. Die Publikation definiert die verschiedenen Gestaltungsparameter, erl{\"a}utert diese und ordnet sie ein. Ebenso wird ein Einblick in den kreativen Gestaltungsprozess von Fußballtrikots gew{\"a}hrt. Das Ziel dieser Publikation besteht darin, das Erscheinungsbild von Trikots zu verstehen und eine kritische Reflexion dar{\"u}ber zu erm{\"o}glichen, wie das Fußballtrikot individuell definiert wird.}, language = {de} } @inproceedings{ScheibeKern2013, author = {Scheibe, K. and Kern, Alexander}, title = {Stand der Normung f{\"u}r {\"U}berspannungsschutzger{\"a}te}, series = {10. VDE, VBB-Blitzschutztagung : Vortr{\"a}ge der 10. VDE, ABB-Fachtagung vom 24. bis 25. Oktober 2013 in Neu-Ulm. (VDE-Fachbericht ; 70)}, booktitle = {10. VDE, VBB-Blitzschutztagung : Vortr{\"a}ge der 10. VDE, ABB-Fachtagung vom 24. bis 25. Oktober 2013 in Neu-Ulm. (VDE-Fachbericht ; 70)}, publisher = {VDE-Verl.}, address = {Berlin}, organization = {Blitzschutztagung <10, 2013, Neu-Ulm>}, isbn = {978-3-8007-3540-2}, pages = {23 -- 27}, year = {2013}, language = {de} } @article{ScheibeKern2011, author = {Scheibe, Klaus and Kern, Alexander}, title = {Aktueller Stand der Normung zum {\"U}berspannungschutz}, series = {9. VDE/ABB-Blitzschutztagung : Vortr{\"a}ge der 9. VDE/ABB-Fachtagung vom 27. bis 28. Oktober 2011 in Neu-Ulm / Veranst.: Ausschuss f{\"u}r Blitzschutz und Blitzforschung (ABB) im VDE Verband der Elektrotechnik Elektronik Informationstechnik e.V. Wiss. Tagungsleitung: K. Stimper}, journal = {9. VDE/ABB-Blitzschutztagung : Vortr{\"a}ge der 9. VDE/ABB-Fachtagung vom 27. bis 28. Oktober 2011 in Neu-Ulm / Veranst.: Ausschuss f{\"u}r Blitzschutz und Blitzforschung (ABB) im VDE Verband der Elektrotechnik Elektronik Informationstechnik e.V. Wiss. Tagungsleitung: K. Stimper}, publisher = {VDE-Verl.}, address = {Berlin}, isbn = {978-3-8007-3380-4}, pages = {13 -- 17}, year = {2011}, language = {de} } @article{ScheidweilerTriesch2016, author = {Scheidweiler, Robert and Triesch, Eberhard}, title = {A note on the duality between matchings and vertex covers in balanced hypergraphs}, series = {Journal of Combinatorial Optimization}, volume = {32}, journal = {Journal of Combinatorial Optimization}, number = {2}, publisher = {Springer}, address = {Berlin}, issn = {1573-2886}, doi = {10.1007/s10878-015-9887-5}, pages = {639 -- 644}, year = {2016}, abstract = {We present a new Min-Max theorem for an optimization problem closely connected to matchings and vertex covers in balanced hypergraphs. The result generalizes Kőnig's Theorem (Berge and Las Vergnas in Ann N Y Acad Sci 175:32-40, 1970; Fulkerson et al. in Math Progr Study 1:120-132, 1974) and Hall's Theorem (Conforti et al. in Combinatorica 16:325-329, 1996) for balanced hypergraphs.}, language = {en} } @inproceedings{ScheikReisgenSchleseretal.2012, author = {Scheik, Sven and Reisgen, Uwe and Schleser, Markus and Huber, Frederic}, title = {Untersuchungen zum dehnungsbasierten Versagen von geklebten, oberfl{\"a}chenveredelten Blechen im Zugscherversuch}, series = {2. Doktorandenseminar Klebtechnik : Vortr{\"a}ge der gleichnamigen Veranstaltung in Dresden am 5. und 6. September 2011}, booktitle = {2. Doktorandenseminar Klebtechnik : Vortr{\"a}ge der gleichnamigen Veranstaltung in Dresden am 5. und 6. September 2011}, publisher = {DVS-Media}, address = {D{\"u}sseldorf}, organization = {Institut f{\"u}r Schweißtechnik und F{\"u}getechnik Aachen> ; Doktorandenseminar Klebtechnik <2, 2011, Dresden>}, isbn = {978-3-87155-599-2}, pages = {73 -- 78}, year = {2012}, language = {de} } @inproceedings{ScheikReisgenSchleseretal.2012, author = {Scheik, Sven and Reisgen, Uwe and Schleser, Markus and Huber, Frederic}, title = {Untersuchungen zum dehnungsbasierten Versagen von geklebten, oberfl{\"a}chenveredelten Blechen im Zugscherversuch}, series = {2. Doktorandenseminar Klebtechnik : Vortr{\"a}ge der gleichnamigen Veranstaltung in Dresden am 5. und 6. September 2011. (DVS-Berichte ; 292)}, booktitle = {2. Doktorandenseminar Klebtechnik : Vortr{\"a}ge der gleichnamigen Veranstaltung in Dresden am 5. und 6. September 2011. (DVS-Berichte ; 292)}, publisher = {DVS Media}, address = {D{\"u}sseldorf}, organization = {Doktorandenseminar Klebtechnik <2, 2011, Dresden> ; Institut f{\"u}r Schweißtechnik und F{\"u}getechnik }, isbn = {978-3-87155-599-2}, pages = {73 -- 78}, year = {2012}, language = {de} }