@article{SiqueiraMolinnusBegingetal.2014, author = {Siqueira, Jose R. and Molinnus, Denise and Beging, Stefan and Sch{\"o}ning, Michael Josef}, title = {Incorporating a hybrid urease-carbon nanotubes sensitive nanofilm on capacitive field-effect sensors for urea detection}, series = {Analytical chemistry}, volume = {86}, journal = {Analytical chemistry}, number = {11}, publisher = {ACS Publications}, address = {Columbus}, issn = {1520-6882 (E-Journal); 0003-2700 (Print); 0096-4484 (Print)}, doi = {10.1021/ac500458s}, pages = {5370 -- 5375}, year = {2014}, abstract = {The ideal combination among biomolecules and nanomaterials is the key for reaching biosensing units with high sensitivity. The challenge, however, is to find out a stable and sensitive film architecture that can be incorporated on the sensor's surface. In this paper, we report on the benefits of incorporating a layer-by-layer (LbL) nanofilm of polyamidoamine (PAMAM) dendrimer and carbon nanotubes (CNTs) on capacitive electrolyte-insulator-semiconductor (EIS) field-effect sensors for detecting urea. Three sensor arrangements were studied in order to investigate the adequate film architecture, involving the LbL film with the enzyme urease: (i) urease immobilized directly onto a bare EIS [EIS-urease] sensor; (ii) urease atop the LbL film over the EIS [EIS-(PAMAM/CNT)-urease] sensor; and (iii) urease sandwiched between the LbL film and another CNT layer [EIS-(PAMAM/CNT)-urease-CNT]. The surface morphology of all three urea-based EIS biosensors was investigated by atomic force microscopy (AFM), while the biosensing abilities were studied by means of capacitance-voltage (C/V) and dynamic constant-capacitance (ConCap) measureaments at urea concentrations ranging from 0.1 mM to 100 mM. The EIS-urease and EIS-(PAMAM/CNT)-urease sensors showed similar sensitivity (∼18 mV/decade) and a nonregular signal behavior as the urea concentration increased. On the other hand, the EIS-(PAMAM/CNT)-urease-CNT sensor exhibited a superior output signal performance and higher sensitivity of about 33 mV/decade. The presence of the additional CNT layer was decisive to achieve a urea based EIS sensor with enhanced properties. Such sensitive architecture demonstrates that the incorporation of an adequate hybrid enzyme-nanofilm as sensing unit opens new prospects for biosensing applications using the field-effect sensor platform.}, language = {en} } @article{HeinzelSchaeferMuelleretal.2010, author = {Heinzel, Alexander and Sch{\"a}fer, Ralf and M{\"u}ller, Hans-Wilhelm and Schieffer, Andre and Ingenhag, Ariane and Eickhoff, Simon B. and Northoff, Georg and Franz, Matthias and Hautzel, Hubertus}, title = {Increased Activation of the Supragenual Anterior Cingulate Cortex during Visual Emotional Processing in Male Subjects with High Degrees of Alexithymia: An Event-Related fMRI Study}, series = {Psychotherapy and Psychosomatics}, volume = {79}, journal = {Psychotherapy and Psychosomatics}, number = {6}, publisher = {Karger}, address = {Basel}, issn = {0033-3190}, doi = {10.1159/000320121}, pages = {363 -- 370}, year = {2010}, abstract = {Background: One of the most prominent neurobiological models of alexithymia assumes an altered function of the anterior cingulate cortex (ACC) as the crucial neural correlate of alexithymia. So far functional imaging studies have yielded inconclusive results. Therefore, we tested this hypothesis in healthy alexithymics and nonalexithymics in an event-related fMRI study. Methods: Thirty high- and 30 low-alexithymic right-handed male subjects (selected by the 20-item Toronto Alexithymia Scale, TAS-20) were investigated with event-related fMRI using a picture viewing paradigm. The stimuli consisted of happy, fearful and neutral facial expressions (Ekman-Friesen) as well as positive, negative and neutral pictures from the International Affective Picture System. Results: Contrasting the high-alexithymic with the low-alexithymic group we observed increased activation of the supragenual ACC for different emotional valences as well as for different emotional stimuli. Moreover, there was a positive correlation of the ACC with the individual TAS-20 scores but no correlations with the individual Beck Depression Inventory scores. Additionally, there was no difference in activity of the amygdala. Conclusions: We demonstrated that the supragenual ACC is constantly activated more strongly in alexithymic subjects and that this activation is related to the symptoms of alexithymia and not to associated symptoms such as depression. Therefore, our findings support the hypothesis of an altered function of the ACC in alexithymia.}, language = {en} } @article{EngelHoltmannUlberetal.2018, author = {Engel, Mareike and Holtmann, Dirk and Ulber, Roland and Tippk{\"o}tter, Nils}, title = {Increased Biobutanol Production by Mediator-Less Electro-Fermentation}, series = {Biotechnology Journal}, volume = {14}, journal = {Biotechnology Journal}, number = {4}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1860-7314}, doi = {10.1002/biot.201800514}, year = {2018}, abstract = {A future bio-economy should not only be based on renewable raw materials but also in the raise of carbon yields of existing production routes. Microbial electrochemical technologies are gaining increased attention for this purpose. In this study, the electro-fermentative production of biobutanol with C. acetobutylicum without the use of exogenous mediators is investigated regarding the medium composition and the reactor design. It is shown that the use of an optimized synthetic culture medium allows higher product concentrations, increased biofilm formation, and higher conductivities compared to a synthetic medium supplemented with yeast extract. Moreover, the optimization of the reactor system results in a doubling of the maximum product concentrations for fermentation products. When a working electrode is polarized at -600 mV vs. Ag/AgCl, a shift from butyrate to acetone and butanol production is induced. This leads to an increased final solvent yield of Yᴀᴃᴇ = 0.202 gg⁻¹ (control 0.103 gg⁻¹), which is also reflected in a higher carbon efficiency of 37.6\% compared to 23.3\% (control) as well as a fourfold decrease in simplified E-factor to 0.43. The results are promising for further development of biobutanol production in bioelectrochemical systems in order to fulfil the principles of Green Chemistry.}, language = {en} } @article{HeinkeKnickerAlbracht2020, author = {Heinke, Lars N. and Knicker, Axel J. and Albracht, Kirsten}, title = {Increased shoulder muscle stretch reflex elicitability in supine subject posture}, series = {Isokinetics and Exercise Science}, volume = {28}, journal = {Isokinetics and Exercise Science}, number = {2}, publisher = {IOS Press}, address = {Amsterdam}, issn = {1878-5913}, doi = {10.3233/IES-192219}, pages = {139 -- 146}, year = {2020}, abstract = {BACKGROUND: Muscle stretch reflexes are widely used to examine neural muscle function. The knowledge of reflex response in muscles crossing the shoulder is limited. OBJECTIVE: To quantify reflex modulation according to various subject postures and different procedures of muscle pre-activation steering. METHODS: Thirteen healthy male participants performed two sets of external shoulder rotation stretches in various positions and with different procedures of muscle pre-activation steering on an isokinetic dynamometer over a range of two different pre-activation levels. All stretches were applied with a dynamometer acceleration of 104∘/s2 and a velocity of 150∘/s. Electromyographical response was measured via sEMG. RESULTS: Consistent reflexive response was observed in all tested muscles in all experimental conditions. The reflex elicitation rate revealed a significant muscle main effect (F (5,288) = 2.358, ρ= 0.040; η2= 0.039; f= 0.637) and a significant test condition main effect (F (1,288) = 5.884, ρ= 0.016; η2= 0.020; f= 0.143). Reflex latency revealed a significant muscle pre-activation level main effect (F (1,274) = 5.008, ρ= 0.026; η2= 0.018; f= 0.469). CONCLUSION: Muscular reflexive response was more consistent in the primary internal rotators of the shoulder. Supine posture in combination with visual feedback of muscle pre-activation level enhanced the reflex elicitation rate.}, language = {en} } @article{LevesqueSiegwolfEilmannetal.2014, author = {L{\´e}vesque, Mathieu and Siegwolf, Rolf and Eilmann, Britta and Saurer, Matthias and Rigling, Andreas}, title = {Increased water-use efficiency does not lead to enhanced tree growth under xeric and mesic conditions}, series = {New Phytologist}, volume = {203}, journal = {New Phytologist}, number = {1}, publisher = {Wiley-Blackwell}, address = {Oxford}, issn = {1469-8137 (Online)}, doi = {10.1111/nph.12772}, pages = {94 -- 109}, year = {2014}, language = {en} } @article{MartinezJakobTuetal.2013, author = {Martinez, Ronny and Jakob, Felix and Tu, Ran and Siegert, Petra and Maurer, Karl-Heinz and Schwaneberg, Ulrich}, title = {Increasing activity and thermal resistance of Bacillus gibsonii alkaline protease (BgAP) by directed evolution}, series = {Biotechnology and bioengineering}, volume = {Vol. 110}, journal = {Biotechnology and bioengineering}, number = {Iss. 3}, publisher = {Wiley}, address = {Weinheim}, issn = {1097-0290 (E-Journal); 0006-3592 (Print); 0368-1467 (Print)}, pages = {711 -- 720}, year = {2013}, language = {en} } @inproceedings{ThenentDahmann2011, author = {Thenent, N. E. and Dahmann, Peter}, title = {Increasing aircraft design flexibility - The development of a hydrostatic transmission for gliders with self-launching capability}, series = {Deutscher Luft- und Raumfahrtkongress 2011 : Bremen, 27. bis 29. September 2011 ; Tagungsband}, booktitle = {Deutscher Luft- und Raumfahrtkongress 2011 : Bremen, 27. bis 29. September 2011 ; Tagungsband}, publisher = {Dt. Gesellschaft f{\"u}r Luft- und Raumfahrt}, address = {Bonn}, isbn = {978-3-9321-8274-7}, pages = {865 -- 883}, year = {2011}, language = {en} } @article{KraftHeerRetkowitz2008, author = {Kraft, Bodo and Heer, Thomas and Retkowitz, Daniel}, title = {Incremental Ontology Integration / Heer, Thomas ; Retkowitz, Daniel ; Kraft, Bodo}, series = {Proceedings of the 10th International Conference on Enterprise Information Systems : Barcelona, Spain, June 12 - 16, 2008 / organized by INSTICC, Institute for Systems and Technologies of Information, Control and Communication ... [Ed. by Jos{\´e} Cordeiro ...]}, journal = {Proceedings of the 10th International Conference on Enterprise Information Systems : Barcelona, Spain, June 12 - 16, 2008 / organized by INSTICC, Institute for Systems and Technologies of Information, Control and Communication ... [Ed. by Jos{\´e} Cordeiro ...]}, publisher = {INSTICC}, address = {Setubal}, pages = {13 -- 28}, year = {2008}, language = {en} } @inproceedings{NiemuellerLakemeyerFerrein2013, author = {Niem{\"u}ller, Tim and Lakemeyer, Gerhard and Ferrein, Alexander}, title = {Incremental task-level reasoning in a competitive factory automation scenario}, series = {Designing intelligent robots : reintegrating AI II ; papers from the AAAI spring symposium ; [held March 25 - 27, 2013 in Palo Alto, California, USA, on the campus of Stanford University]. (Technical Report / Association for the Advancement of Artificial Intelligence ; 2013,4)}, booktitle = {Designing intelligent robots : reintegrating AI II ; papers from the AAAI spring symposium ; [held March 25 - 27, 2013 in Palo Alto, California, USA, on the campus of Stanford University]. (Technical Report / Association for the Advancement of Artificial Intelligence ; 2013,4)}, editor = {Boots, Byron}, organization = {American Association for Artificial Intelligence}, isbn = {9781577356011}, pages = {43 -- 48}, year = {2013}, language = {en} } @article{HenriquesJuradoGrieseretal.2020, author = {Henriques, A. and Jurado, B. and Grieser, M. and Denis-Petit, D. and Chiron, T. and Gaudefroy, L. and Glorius, J. and Langer, Christoph and Litvinov, Yu. A. and Mathieu, L. and Meot, V. and Perez-Sanchez, R. and Pibernat, J. and Reifarth, R. and Roig, O. and Thomas, B. and Thomas, B. A. and Thomas, J. C. and Tsekhanovich, I.}, title = {Indirect measurements of neutron cross-secti at heavy-ion storage rings}, series = {Journal of Physics: Conference Series}, volume = {1668}, journal = {Journal of Physics: Conference Series}, number = {Art. 012019}, publisher = {IOP}, address = {Bristol}, doi = {10.1088/1742-6596/1668/1/012019}, year = {2020}, abstract = {Cross sections for neutron-induced reactions of short-lived nuclei are essential for nuclear astrophysics since these reactions in the stars are responsible for the production of most heavy elements in the universe. These reactions are also key in applied domains like energy production and medicine. Nevertheless, neutron-induced cross-section measurements can be extremely challenging or even impossible to perform due to the radioactivity of the targets involved. Indirect measurements through the surrogate-reaction method can help to overcome these difficulties. The surrogate-reaction method relies on the use of an alternative reaction that will lead to the formation of the same excited nucleus as in the neutron-induced reaction of interest. The decay probabilities (for fission, neutron and gamma-ray emission) of the nucleus produced via the surrogate reaction allow one to constrain models and the prediction of the desired neutron cross sections. We propose to perform surrogate reaction measurements in inverse kinematics at heavy-ion storage rings, in particular at the CRYRING@ESR of the GSI/FAIR facility. We present the conceptual idea of the most promising setup to measure for the first time simultaneously the fission, neutron and gamma-ray emission probabilities. The results of the first simulations considering the 238U(d,d') reaction are shown, as well as new technical developments that are being carried out towards this set-up.}, language = {en} }