@article{ScheerWolf2014, author = {Scheer, Nico and Wolf, C. Roland}, title = {Genetically humanized mouse models of drug metabolizing enzymes and transporters and their applications}, series = {Xenobiotica}, volume = {44}, journal = {Xenobiotica}, number = {2}, publisher = {Taylor \& Francis}, address = {Abingdon}, issn = {1366-5928}, doi = {10.3109/00498254.2013.815831}, pages = {96 -- 108}, year = {2014}, abstract = {1. Drug metabolizing enzymes and transporters play important roles in the absorption, metabolism, tissue distribution and excretion of various compounds and their metabolites and thus can significantly affect their efficacy and safety. Furthermore, they can be involved in drug-drug interactions which can result in adverse responses, life-threatening toxicity or impaired efficacy. Significant species differences in the interaction of compounds with drug metabolizing enzymes and transporters have been described. 2. In order to overcome the limitation of animal models in accurately predicting human responses, a large variety of mouse models humanized for drug metabolizing enzymes and to a lesser extent drug transporters have been created. 3. This review summarizes the literature describing these mouse models and their key applications in studying the role of drug metabolizing enzymes and transporters in drug bioavailability, tissue distribution, clearance and drug-drug interactions as well as in human metabolite testing and risk assessment. 4. Though such humanized mouse models have certain limitations, there is great potential for their use in basic research and for testing and development of new medicines. These limitations and future potentials will be discussed.}, language = {en} } @book{SchulteZurhausen2014, author = {Schulte-Zurhausen, Manfred}, title = {Organisation}, edition = {6., {\"u}berarb. und aktualisierte Aufl.}, publisher = {Vahlen}, address = {M{\"u}nchen}, isbn = {978-3-8006-4689-0}, pages = {XVI, 687 S. : graph. Darst.}, year = {2014}, language = {de} } @inproceedings{SchirraBauschatWatmuff2014, author = {Schirra, Julian and Bauschat, J.-Michael and Watmuff, J.H.}, title = {Accurate induced drag prediction for highly non-planar lifting systems}, series = {19th Australasian Fluid Mechanics Conference : 8.-11. Dezember 2014, Melbourne, Australia}, booktitle = {19th Australasian Fluid Mechanics Conference : 8.-11. Dezember 2014, Melbourne, Australia}, pages = {4 Seiten}, year = {2014}, abstract = {The impact of wake model effects is investigated for two highly non-planar lifting systems. Dependent on the geometrical arrangement of the configuration, the wake model shape is found to considerably affect the estimation. Particularly at higher angles of attack, an accurate estimation based on the common linear wake model approaches is involved.}, language = {en} } @article{JoerissenHeger2014, author = {J{\"o}rissen, J{\"o}rg and Heger, Michael}, title = {Zur Wirkung hochschuldidaktisch fundierter und in den Fachbereichen verankerter Lehrveranstaltungsevaluation}, series = {Qualit{\"a}t in der Wissenschaft (QiW)}, volume = {8}, journal = {Qualit{\"a}t in der Wissenschaft (QiW)}, number = {2+3}, publisher = {Universit{\"a}tsverlag Webler}, address = {Bielefeld}, issn = {1860-3041}, pages = {70 -- 80}, year = {2014}, language = {de} } @article{Wilke2014, author = {Wilke, Thomas}, title = {Gebaute Geschichte in Turin}, series = {Kunsttexte.de}, volume = {2014}, journal = {Kunsttexte.de}, number = {1}, publisher = {Humboldt-Universit{\"a}t zu Berlin}, address = {Berlin}, issn = {1618-8101}, doi = {10.18452/7197}, pages = {13 Seiten}, year = {2014}, abstract = {St{\"a}dte sind Stein gewordene Geschichte. Ihre realisierte Form erm{\"o}glicht Geschichte zu erleben und die Stadtentwicklung nachzuvollziehen. Besonders in Turin ist ablesbar, wie das Haus Savoyen den Ausbau der neuen Hauptstadt zu einer der f{\"u}hrenden Barockmetropolen Europas beeinflusste.}, language = {de} } @article{KrollLudwigsKaesling2014, author = {Kroll-Ludwigs, Kathrin and Kaesling, Katharina}, title = {Family Law and Culture in Europe: Developments, Challenges and Opportunities - Konferenz der Commission on European Family Law vom 29.-31. August 2013, Bonn}, series = {Zeitschrift f{\"u}r Europ{\"a}isches Privatrecht (ZEuP)}, journal = {Zeitschrift f{\"u}r Europ{\"a}isches Privatrecht (ZEuP)}, number = {3}, publisher = {Beck}, address = {M{\"u}nchen}, issn = {0943-3929}, pages = {673 -- 676}, year = {2014}, abstract = {Vor dem Hintergrund zunehmender gesellschaftlicher Ver{\"a}nderungen bei den Lebens- und Familienformen hat es sich die Commission on European Family Law (CEFL) seit 2001 zum Ziel gesetzt, unverbindliche Regelungsvorschl{\"a}ge f{\"u}r ein europaweit einheitliches Familienrecht zu schaffen. Die Vorstellung und Diskussion dieser auf rechtsvergleichender Basis erstellten Principles erfolgt auf den regelm{\"a}ßig veranstalteten Tagungen der CEFL. Die nunmehr f{\"u}nfte Konferenz zum Thema „Family Law and Culture in Europe - Developments, Challenges and Opportunities" fand erstmals in Deutschland statt. Ausgerichtet wurde die Veranstaltung, zu der ca. 200 Teilnehmerinnen und Teilnehmern aus Wissenschaft und Praxis aus insgesamt 33 L{\"a}ndern angereist waren, von Nina Dethloff (Direktorin des Instituts f{\"u}r Deutsches, Europ{\"a}isches und Internationales Familienrecht an der Universit{\"a}t Bonn), Katharina Boele-Woelki (Direktorin des Utrecht Centre for European Research into Family Law und Preistr{\"a}gerin des Anneliese Maier-Forschungspreises der Alexander von Humboldt-Stiftung) und Werner Gephart (Direktor des K{\"a}te Hamburger Kollegs „Recht als Kultur").}, language = {de} } @article{Bernecker2014, author = {Bernecker, Andreas}, title = {Do politicians shirk when reelection is certain? Evidence from the German parliament}, series = {European Journal of Political Economy}, volume = {36}, journal = {European Journal of Political Economy}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0176-2680}, doi = {10.1016/j.ejpoleco.2014.07.001}, pages = {55 -- 70}, year = {2014}, abstract = {Does stiffer electoral competition reduce political shirking? For a micro-analysis of this question, I construct a new data set spanning the years 2005 to 2012 covering biographical and political information about German Members of Parliament (MPs), including their attendance rates in voting sessions. For the parliament elected in 2009, I show that indeed opposition party MPs who expect to face a close race in their district show significantly and relevantly lower absence rates in parliament beforehand. MPs of governing parties seem not to react significantly to electoral competition. These results are confirmed by an analysis of the parliament elected in 2005, by several robustness checks, and also by employing an instrumental variable strategy exploiting convenient peculiarities of the German electoral system. The study also shows how MPs elected via party lists react to different levels of electoral competition.}, language = {en} } @article{Bernecker2014, author = {Bernecker, Andreas}, title = {Divided Government and the Adoption of Economic Reforms}, series = {CESifo DICE Report - Journal for Institutional Comparison}, volume = {12}, journal = {CESifo DICE Report - Journal for Institutional Comparison}, number = {4}, publisher = {Ifo Institute for Economic Research}, address = {M{\"u}nchen}, issn = {1612-0663}, pages = {47 -- 52}, year = {2014}, language = {en} } @book{Bernecker2014, author = {Bernecker, Andreas}, title = {Essays in Empirical Political Economics}, pages = {XI, 174 S. : Ill., graph. Darst.}, year = {2014}, language = {en} } @article{AltherrEdererLorenzetal.2014, author = {Altherr, Lena and Ederer, Thorsten and Lorenz, Ulf and Pelz, Peter F. and P{\"o}ttgen, Philipp}, title = {Experimental validation of an enhanced system synthesis approach}, series = {Operations Research Proceedings 2014}, journal = {Operations Research Proceedings 2014}, editor = {L{\"u}bbecke, Marco and Koster, Arie and Letmathe, Peter and Madlener, Reihard and Peis, Britta and Walther, Grit}, publisher = {Springer}, address = {Basel}, isbn = {978-3-319-28695-2}, doi = {10.1007/978-3-319-28697-6_1}, pages = {6}, year = {2014}, abstract = {Planning the layout and operation of a technical system is a common task for an engineer. Typically, the workflow is divided into consecutive stages: First, the engineer designs the layout of the system, with the help of his experience or of heuristic methods. Secondly, he finds a control strategy which is often optimized by simulation. This usually results in a good operating of an unquestioned sys- tem topology. In contrast, we apply Operations Research (OR) methods to find a cost-optimal solution for both stages simultaneously via mixed integer program- ming (MILP). Technical Operations Research (TOR) allows one to find a provable global optimal solution within the model formulation. However, the modeling error due to the abstraction of physical reality remains unknown. We address this ubiq- uitous problem of OR methods by comparing our computational results with mea- surements in a test rig. For a practical test case we compute a topology and control strategy via MILP and verify that the objectives are met up to a deviation of 8.7\%.}, language = {en} }