@article{VarrialeHengsbachGuoetal.2024, author = {Varriale, Ludovica and Hengsbach, Jan-Niklas and Guo, Tianyi and Kuka, Katrin and Tippk{\"o}tter, Nils and Ulber, Roland}, title = {Sustainable production of lactic acid using a perennial ryegrass as feedstock—a comparative study of fermentation at the bench- and reactor-scale, and ensiling}, series = {Sustainability}, volume = {16}, journal = {Sustainability}, number = {18}, publisher = {MDPI}, address = {Basel}, issn = {2071-1050}, doi = {10.3390/su16188054}, year = {2024}, abstract = {Perennial ryegrass (Lolium perenne) is an underutilized lignocellulosic biomass that has several benefits such as high availability, renewability, and biomass yield. The grass press-juice obtained from the mechanical pretreatment can be used for the bio-based production of chemicals. Lactic acid is a platform chemical that has attracted consideration due to its broad area of applications. For this reason, the more sustainable production of lactic acid is expected to increase. In this work, lactic acid was produced using complex medium at the bench- and reactor scale, and the results were compared to those obtained using an optimized press-juice medium. Bench-scale fermentations were carried out in a pH-control system and lactic acid production reached approximately 21.84 ± 0.95 g/L in complex medium, and 26.61 ± 1.2 g/L in press-juice medium. In the bioreactor, the production yield was 0.91 ± 0.07 g/g, corresponding to a 1.4-fold increase with respect to the complex medium with fructose. As a comparison to the traditional ensiling process, the ensiling of whole grass fractions of different varieties harvested in summer and autumn was performed. Ensiling showed variations in lactic acid yields, with a yield up to 15.2\% dry mass for the late-harvested samples, surpassing typical silage yields of 6-10\% dry mass.}, language = {en} } @article{BaeckerKochEibenetal.2017, author = {B{\"a}cker, Matthias and Koch, Claudia and Eiben, Sabine and Geiger, Fania and Eber, Fabian and Gliemann, Hartmut and Poghossian, Arshak and Wege, Christina and Sch{\"o}ning, Michael Josef}, title = {Tobacco mosaic virus as enzyme nanocarrier for electrochemical biosensors}, series = {Sensors and Actuators B: Chemical}, volume = {238}, journal = {Sensors and Actuators B: Chemical}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0925-4005}, doi = {10.1016/j.snb.2016.07.096}, pages = {716 -- 722}, year = {2017}, abstract = {The conjunction of (bio-)chemical recognition elements with nanoscale biological building blocks such as virus particles is considered as a very promising strategy for the creation of biohybrids opening novel opportunities for label-free biosensing. This work presents a new approach for the development of biosensors using tobacco mosaic virus (TMV) nanotubes or coat proteins (CPs) as enzyme nanocarriers. Sensor chips combining an array of Pt electrodes loaded with glucose oxidase (GOD)-modified TMV nanotubes or CP aggregates were used for amperometric detection of glucose as a model system for the first time. The presence of TMV nanotubes or CPs on the sensor surface allows binding of a high amount of precisely positioned enzymes without substantial loss of their activity, and may also ensure accessibility of their active centers for analyte molecules. Specific and efficient immobilization of streptavidin-conjugated GOD ([SA]-GOD) complexes on biotinylated TMV nanotubes or CPs was achieved via bioaffinity binding. These layouts were tested in parallel with glucose sensors with adsorptively immobilized [SA]-GOD, as well as [SA]-GOD crosslinked with glutardialdehyde, and came out to exhibit superior sensor performance. The achieved results underline a great potential of an integration of virus/biomolecule hybrids with electronic transducers for future applications in biosensorics and biochips.}, language = {en} } @article{KochPoghossianSchoeningetal.2018, author = {Koch, Claudia and Poghossian, Arshak and Sch{\"o}ning, Michael Josef and Wege, Christian}, title = {Penicillin Detection by Tobacco Mosaic Virus-Assisted Colorimetric Biosensors}, series = {Nanotheranostics}, volume = {2}, journal = {Nanotheranostics}, number = {2}, publisher = {Ivyspring}, address = {Sydney}, issn = {2206-7418}, doi = {10.7150/ntno.22114}, pages = {184 -- 196}, year = {2018}, abstract = {The presentation of enzymes on viral scaffolds has beneficial effects such as an increased enzyme loading and a prolonged reusability in comparison to conventional immobilization platforms. Here, we used modified tobacco mosaic virus (TMV) nanorods as enzyme carriers in penicillin G detection for the first time. Penicillinase enzymes were conjugated with streptavidin and coupled to TMV rods by use of a bifunctional biotin-linker. Penicillinase-decorated TMV particles were characterized extensively in halochromic dye-based biosensing. Acidometric analyte detection was performed with bromcresol purple as pH indicator and spectrophotometry. The TMV-assisted sensors exhibited increased enzyme loading and strongly improved reusability, and higher analysis rates compared to layouts without viral adapters. They extended the half-life of the sensors from 4 - 6 days to 5 weeks and thus allowed an at least 8-fold longer use of the sensors. Using a commercial budget-priced penicillinase preparation, a detection limit of 100 µM penicillin was obtained. Initial experiments also indicate that the system may be transferred to label-free detection layouts.}, language = {en} } @article{EschWoltersSalberetal.2001, author = {Esch, Thomas and Wolters, Peter and Salber, Wolfgang and Geiger, Jos{\´e}}, title = {Variable Ventilsteuerung und Direkteinspritzung - vom Wettbewerb zur Synergie}, series = {Motor und Umwelt 2001, Internal Combustion Engine Versus Fuel Cell - Potential and Limitations as Automotive Power Sources, Verbrennungsmotor versus Brennstoffzelle - Potenziale und Grenzen f{\"u}r den Automobilantrieb, Proc., Graz, AT, 6.-7. Sep, 2001}, journal = {Motor und Umwelt 2001, Internal Combustion Engine Versus Fuel Cell - Potential and Limitations as Automotive Power Sources, Verbrennungsmotor versus Brennstoffzelle - Potenziale und Grenzen f{\"u}r den Automobilantrieb, Proc., Graz, AT, 6.-7. Sep, 2001}, pages = {183 -- 206}, year = {2001}, language = {de} } @article{SpietzSproewitzSeefeldtetal.2021, author = {Spietz, Peter and Spr{\"o}witz, Tom and Seefeldt, Patric and Grundmann, Jan Thimo and Jahnke, Rico and Mikschl, Tobias and Mikulz, Eugen and Montenegro, Sergio and Reershemius, Siebo and Renger, Thomas and Ruffer, Michael and Sasaki, Kaname and Sznajder, Maciej and T{\´o}th, Norbert and Ceriotti, Matteo and Dachwald, Bernd and Macdonald, Malcolm and McInnes, Colin and Seboldt, Wolfgang and Quantius, Dominik and Bauer, Waldemar and Wiedemann, Carsten and Grimm, Christian D. and Hercik, David and Ho, Tra-Mi and Lange, Caroline and Schmitz, Nicole}, title = {Paths not taken - The Gossamer roadmap's other options}, series = {Advances in Space Research}, volume = {67}, journal = {Advances in Space Research}, number = {9}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0273-1177}, doi = {10.1016/j.asr.2021.01.044}, pages = {2912 -- 2956}, year = {2021}, language = {en} } @article{SchmitzPischinger1997, author = {Schmitz, G{\"u}nter and Pischinger, Martin}, title = {Mechatronische Simulation eines EMV- Aktuators}, series = {TransMechatronik : Entwicklung und Transfer von Entwicklungssystemen der Mechatronik / Paderborner Workshop TransMechatronik, 24. Juni 1997, Heinz-Nixdorf-MuseumsForum. [Hrsg. J{\"u}rgen Gausemeier]}, journal = {TransMechatronik : Entwicklung und Transfer von Entwicklungssystemen der Mechatronik / Paderborner Workshop TransMechatronik, 24. Juni 1997, Heinz-Nixdorf-MuseumsForum. [Hrsg. J{\"u}rgen Gausemeier]}, publisher = {Heinz-Nixdorf-Inst., Univ.-GH Paderborn}, address = {Paderborn}, isbn = {3-931466-22-1}, pages = {69 -- 83}, year = {1997}, language = {de} } @article{EschGoebelPischinger1995, author = {Esch, Thomas and G{\"o}bel, T. and Pischinger, Martin}, title = {Variable Ventilsteuerung - Luft- und Kraftstoffzumessung bei Ottomotoren mit variabler Ventilsteuerung}, series = {Forschungsberichte Verbrennungskraftmaschinen. 578 (1995)}, journal = {Forschungsberichte Verbrennungskraftmaschinen. 578 (1995)}, pages = {1 -- 42}, year = {1995}, language = {de} } @article{BegingMlynekHataihimakuletal.2010, author = {Beging, Stefan and Mlynek, Daniela and Hataihimakul, Sudkanung and Poghossian, Arshak and Baldsiefen, Gerhard and Busch, Heinz and Laube, Norbert and Kleinen, Lisa and Sch{\"o}ning, Michael Josef}, title = {Field-effect calcium sensor for the determination of the risk of urinary stone formation}, series = {Sensors and Actuators B: Chemical}, volume = {144}, journal = {Sensors and Actuators B: Chemical}, number = {2}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0925-4005}, doi = {10.1016/j.snb.2008.12.012}, pages = {374 -- 379}, year = {2010}, abstract = {Urinary stone formation has been evolved to a widespread disease during the last years. The reason for the formation of urinary stones are little crystals, mostly composed of calcium oxalate, which are formed in human kidneys. The early diagnosis of the risk for urinary stone formation of patients can be determined by the "Bonn-Risk-Index" method based on the potentiometric detection of the Ca2+-ion concentration and an optical determination of the triggered crystallisation of calcium oxalate in unprocessed urine. In this work, miniaturised capacitive field-effect EMIS (electrolyte-membrane-insulator-semiconductor) sensors have been developed for the determination of the Ca2+-ion concentration in human native urine. The Ca2+-sensitive EMIS sensors have been systematically characterised by impedance spectroscopy, capacitance-voltage and constant-capacitance method in terms of sensitivity, signal stability and response time in both CaCl2 solutions and in native urine. The obtained results demonstrate the suitability of EMIS sensors for the measurement of the Ca2+-ion concentration in native urine of patients.}, language = {en} } @article{ReisertHenkelSchneideretal.2010, author = {Reisert, Steffen and Henkel, Hartmut and Schneider, Andreas and Sch{\"a}fer, Daniel and Friedrich, Peter and Berger, J{\"o}rg and Sch{\"o}ning, Michael Josef}, title = {Development of a handheld sensor system for the online measurement of hydrogen peroxide in aseptic filling systems}, series = {Physica Status Solidi (A)}, volume = {207}, journal = {Physica Status Solidi (A)}, number = {4}, publisher = {Wiley-VCH}, address = {Berlin}, issn = {1862-6300}, doi = {10.1002/pssa.200983304}, pages = {913 -- 918}, year = {2010}, abstract = {A handheld sensor system for the online measurement of hydrogen peroxide (H2O2) in aseptic sterilisation processes has been developed. It is based on a calorimetric-type gas sensor that consists of a differential set-up of two temperature sensors, of which one is catalytically activated and the second one is passivated and used as reference. The sensor principle relies in detecting a rise in temperature on the active sensor due to the exothermic reaction of H2O2 on the catalytic surface. To characterise the sensor system towards H2O2 sensitivity and other influencing factors, measurements have been carried out both at an experimental set-up and a manufacturer's sterilisation machine. Physical sensor characterisation was done by means of the optical microscopy.}, language = {en} } @article{MiyamotoSugawaraKanohetal.2010, author = {Miyamoto, Ko-ichiro and Sugawara, Yuri and Kanoh, Shin´ichiro and Yoshinobu, Tatsuo and Wagner, Torsten and Sch{\"o}ning, Michael Josef}, title = {Image correction method for the chemical imaging sensor}, series = {Sensors and Actuators B: Chemical}, volume = {144}, journal = {Sensors and Actuators B: Chemical}, number = {2}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0925-4005}, doi = {10.1016/j.snb.2008.10.069}, pages = {344 -- 348}, year = {2010}, abstract = {The chemical imaging sensor is a semiconductor-based chemical sensor that can visualize the spatial distribution of chemical species. For the practical application of this sensor, artifacts in the chemical images due to defects of the semiconductor substrate and contamination of the sensing surface etc. have been a major problem. An image correction method was developed to eliminate the influence of nonuniformity of individual sensor plate.}, language = {en} }