@article{BaeckerKramerHucketal.2014, author = {B{\"a}cker, Matthias and Kramer, F. and Huck, Christina and Poghossian, Arshak and Bratov, A. and Abramova, N. and Sch{\"o}ning, Michael Josef}, title = {Planar and 3D interdigitated electrodes for biosensing applications: The impact of a dielectric barrier on the sensor properties}, series = {Physica Status Solidi (A) - Applications and Materials Science}, volume = {211}, journal = {Physica Status Solidi (A) - Applications and Materials Science}, number = {6}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1521-396X (E-Journal); 1862-6319 (E-Journal); 0031-8965 (Print); 1862-6300 (Print)}, doi = {10.1002/pssa.201330416}, pages = {1357 -- 1363}, year = {2014}, abstract = {Planar and three-dimensional (3D) interdigitated electrodes (IDE) with electrode digits separated by an insulating barrier of different heights were electrochemically characterized and compared in terms of their sensing properties. Due to the impact of the surface resistance, both types of IDE structures display a non-linear behavior in low-ionic strength solutions. The experimental data were fitted to an electrical equivalent circuit and interpreted taking into account the surface-charge-governed properties. The effect of a charged polyelectrolyte layer electrostatically assembled onto the sensor surface on the surface resistance in solutions with different KCl concentration is studied. In case of the same electrode footprint, 3D-IDEs show a larger cell constant and a higher sensitivity to molecular adsorption than that of planar IDEs. The obtained results demonstrate the potential of 3D-IDEs as a new transducer structure for a direct label-free sensing of charged molecules.}, language = {en} } @article{WuBronderPoghossianetal.2014, author = {Wu, Chunsheng and Bronder, Thomas and Poghossian, Arshak and Werner, Frederik and B{\"a}cker, Matthias and Sch{\"o}ning, Michael Josef}, title = {Label-free electrical detection of DNA with a multi-spot LAPS: First step towards light-addressable DNA chips}, series = {Physica status solidi A : Applications and materials science}, volume = {211}, journal = {Physica status solidi A : Applications and materials science}, number = {6}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1521-396X (E-Journal); 1862-6319 (E-Journal); 0031-8965 (Print); 1862-6300 (Print)}, doi = {10.1002/pssa.201330442}, pages = {1423 -- 1428}, year = {2014}, abstract = {A multi-spot (4 × 4 spots) light-addressable potentiometric sensor (MLAPS) consisting of an Al-p-Si-SiO2 structure has been applied for the label-free electrical detection of DNA (deoxyribonucleic acid) immobilization and hybridization by the intrinsic molecular charge for the first time. Single-stranded probe ssDNA molecules (20 bases) were covalently immobilized onto the silanized SiO2 gate surface. The unspecific adsorption of mismatch ssDNA on the MLAPS gate surface was blocked by bovine serum albumin molecules. To reduce the screening effect and to achieve a high sensor signal, the measurements were performed in a low ionic-strength solution. The photocurrent-voltage (I-V) curves were simultaneously recorded on all 16 spots after each surface functionalization step. Large shifts of I-V curves of 25 mV were registered after the DNA immobilization and hybridization event. In contrast, a small potential shift (∼5 mV) was observed in case of mismatch ssDNA, revealing good specificity of the sensor. The obtained results demonstrate the potential of the MLAPS as promising transducer platform for the multi-spot label-free electrical detection of DNA molecules by their intrinsic molecular charge.}, language = {en} } @article{PoghossianSchoening2014, author = {Poghossian, Arshak and Sch{\"o}ning, Michael Josef}, title = {Label-free sensing of biomolecules with field-effect devices for clinical applications}, series = {Electroanalysis}, volume = {26}, journal = {Electroanalysis}, number = {6}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1521-4109 (E-Journal); 1040-0397 (Print)}, doi = {10.1002/elan.201400073}, pages = {1197 -- 1213}, year = {2014}, abstract = {Among the variety of transducer concepts proposed for label-free detection of biomolecules, the semiconductor field-effect device (FED) is one of the most attractive platforms. As medical techniques continue to progress towards diagnostic and therapies based on biomarkers, the ability of FEDs for a label-free, fast and real-time detection of multiple pathogenic and physiologically relevant molecules with high specificity and sensitivity offers very promising prospects for their application in point-of-care and personalized medicine for an early diagnosis and treatment of diseases. The presented paper reviews recent advances and current trends in research and development of different FEDs for label-free, direct electrical detection of charged biomolecules by their intrinsic molecular charge. The authors are mainly focusing on the detection of the DNA hybridization event, antibody-antigen affinity reaction as well as clinically relevant biomolecules such as cardiac and cancer biomarkers.}, language = {en} } @article{PhamStaat2014, author = {Pham, Phu Tinh and Staat, Manfred}, title = {FEM-based shakedown analysis of hardening structures}, series = {Asia Pacific journal on computational engineering}, journal = {Asia Pacific journal on computational engineering}, number = {1}, publisher = {SpringerOpen}, address = {Berlin}, issn = {2196-1166 (E-Journal)}, doi = {10.1186/2196-1166-1-4}, pages = {Article No. 4}, year = {2014}, abstract = {This paper develops a new finite element method (FEM)-based upper bound algorithm for limit and shakedown analysis of hardening structures by a direct plasticity method. The hardening model is a simple two-surface model of plasticity with a fixed bounding surface. The initial yield surface can translate inside the bounding surface, and it is bounded by one of the two equivalent conditions: (1) it always stays inside the bounding surface or (2) its centre cannot move outside the back-stress surface. The algorithm gives an effective tool to analyze the problems with a very high number of degree of freedom. Our numerical results are very close to the analytical solutions and numerical solutions in literature.}, language = {en} } @article{Laack2014, author = {Laack, Walter van}, title = {Therefore Fermat is right}, series = {American journal of humanities and social sciences : AJHSS}, volume = {2}, journal = {American journal of humanities and social sciences : AJHSS}, number = {2}, issn = {2329-079X (E-Journal); 2329-0781 (Print)}, pages = {117 -- 120}, year = {2014}, abstract = {It was Fernat's idea to investigate how many numbers would fulfill the equation according to the Pythagorean Theorem if the exponent were increased to random, e.g. to a3 + b3 = c3. His question became therefore: are there two whole numbers the cubes of which add up to the volume of the cube of a third whole number? He posed this same question, of course, for all kinds of higher exponents, so that the equation could be generalized: is there an integral solution for the equation an + bn = cn, if the exponent n is higher than 2? Although in 1993, the English mathematician Andrew Wiles was able to produce an arithmetical proof for Fermat's famous theorem, I will show that there is a simple logical explanation which is also pragmatic and plausible and what is the result of a fundamental alternative idea how our world seems to be constructed.}, language = {en} } @incollection{SchoeningPoghossianGluecketal.2014, author = {Sch{\"o}ning, Michael Josef and Poghossian, Arshak and Gl{\"u}ck, Olaf and Thust, Marion}, title = {Electrochemical composition measurement}, series = {Measurement, instrumentation, and sensors handbook: electromagnetic, optical, radiation, chemical, and biomedical measuremen}, booktitle = {Measurement, instrumentation, and sensors handbook: electromagnetic, optical, radiation, chemical, and biomedical measuremen}, edition = {2nd ed.}, publisher = {CRC Pr.}, address = {Boca Raton, Fa.}, isbn = {978-1-4398-4891-3}, pages = {55-1 -- 55-54}, year = {2014}, language = {en} } @article{HuckPoghossianBaeckeretal.2014, author = {Huck, Christina and Poghossian, Arshak and B{\"a}cker, Matthias and Chaudhuri, S. and Zander, W. and Schubert, J. and Begoyan, V. K. and Buniatyan, V. V. and Wagner, P. and Sch{\"o}ning, Michael Josef}, title = {Capacitively coupled electrolyte-conductivity sensor based on high-k material of barium strontium titanate}, series = {Sensors and actuators. B: Chemical}, journal = {Sensors and actuators. B: Chemical}, number = {198}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1873-3077 (E-Journal); 0925-4005 (Print)}, doi = {10.1016/j.snb.2014.02.103}, pages = {102 -- 109}, year = {2014}, language = {en} } @article{OberlaenderKirchnerBoyenetal.2014, author = {Oberl{\"a}nder, Jan and Kirchner, Patrick and Boyen, Hans-Gerd and Sch{\"o}ning, Michael Josef}, title = {Detection of hydrogen peroxide vapor by use of manganese(IV) oxide as catalyst for calorimetric gas sensors}, series = {Physica status solidi A: Applications and materials science}, volume = {211}, journal = {Physica status solidi A: Applications and materials science}, number = {6}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1521-396X (E-Journal); 1862-6319 (E-Journal); 0031-8965 (Print); 1862-6300 (Print)}, doi = {10.1002/pssa.201330359}, pages = {1372 -- 1376}, year = {2014}, abstract = {In this work, the catalyst manganese(IV) oxide (MnO2), of calorimetric gas sensors (to monitor the sterilization agent vaporized hydrogen peroxide) has been investigated in more detail. Chemical analyses by means of X-ray-induced photoelectron spectroscopy have been performed to unravel the surface chemistry prior and after exposure to hydrogen peroxide vapor at elevated temperature, as applied in the sterilization processes of beverage cartons. The surface characterization reveals a change in oxidation states of the metal oxide catalyst after exposure to hydrogen peroxide. Additionally, a cleaning effect of the catalyst, which itself is attached to the sensor surface by means of a polymer interlayer, could be observed.}, language = {en} } @article{FuestKotliarWalteretal.2014, author = {Fuest, Matthias and Kotliar, Konstantin and Walter, Peter and Plange, Niklas}, title = {Monitoring intraocular pressure changes after intravitreal Ranibizumab injection using rebound tonometry}, series = {Ophthalmic and physiological optics}, volume = {34}, journal = {Ophthalmic and physiological optics}, number = {4}, publisher = {Wiley-Blackwell}, address = {Oxford}, issn = {1475-1313 (E-Journal); 0275-5408 (Print)}, doi = {10.1111/opo.12134}, pages = {438 -- 444}, year = {2014}, language = {en} } @inproceedings{SchreiberBarkschatKraft2014, author = {Schreiber, Marc and Barkschat, Kai and Kraft, Bodo}, title = {Using Continuous Integration to organize and monitor the annotation process of domain specific corpora}, series = {5th International Conference on Information and Communication Systems (ICICS) : 1-3 April 2014, Irbid, Jordanien}, booktitle = {5th International Conference on Information and Communication Systems (ICICS) : 1-3 April 2014, Irbid, Jordanien}, organization = {International Conference on Information and Communication Systems <5, 2014, Irbid, Jordanien>}, isbn = {978-1-4799-3022-7}, doi = {10.1109/IACS.2014.6841958}, pages = {1 -- 6}, year = {2014}, language = {en} }