@misc{ArtmannLinderBayeretal.2017,
  author    = {Artmann, Gerhard and Linder, Peter and Bayer, Robin and Gossmann, Matthias},
  title     = {Celldrum electrode arrangement for measuring mechanical stress [Patent of invention]},
  publisher = {WIPO},
  address   = {Geneva},
  pages     = {18 Seiten},
  year      = {2017},
  abstract  = {The invention pertains to a CellDrum electrode arrangement for measuring mechanical stress, comprising a mechanical holder (1 ) and a non-conductive membrane (4), whereby the membrane (4) is at least partially fixed at its circumference to the mechanical holder (1), keeping it in place when the membrane (4) may bend due to forces acting on the membrane (4), the mechanical holder (1) and the membrane (4) forming a container, whereby the membrane (1) within the container comprises an cell- membrane compound layer or biological material (3) adhered to the deformable membrane 4 which in response to stimulation by an agent may exert mechanical stress to the membrane (4) such that the membrane bending stage changes whereby the container may be filled with an electrolyte, whereby an electric contact (2) is arranged allowing to contact said electrolyte when filled into to the container, whereby within a predefined geometry to the fixing of the membrane (4) an electrode (7) is arranged, whereby the electrode (7) is electrically insulated with respect to the electric contact (2) as well as said electrolyte, whereby mechanical stress due to an agent may be measured as a change in capacitance.},
  language  = {en}
}
@inproceedings{BayerHeschelerArtmannetal.2019,
  author    = {Bayer, Robin and Hescheler, J{\"u}rgen and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l},
  title     = {Treating arterial hypertension in a cell culture well},
  series = {3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH AachenW},
  booktitle = {3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH AachenW},
  editor    = {Staat, Manfred and Erni, Daniel},
  publisher = {Universit{\"a}t Duisburg-Essen},
  address   = {Duisburg},
  organization    = {MedTech Symposium},
  isbn      = {978-3-940402-22-6},
  doi       = {10.17185/duepublico/48750},
  pages     = {5 -- 6},
  year      = {2019},
  abstract  = {Hypertension describes the pathological increase of blood pressure, which is most commonly associated with the increase of vascular wall stiffness [1]. Referring to the "Deutsche Bluthochdruck Liga" this pathology shows a growing trend in our aging society. In order to find novel pharmacological and probably personalized treatments, we want to present a functional approach to study biomechanical properties of a human aortic vascular model. In this method review we will give an overview of recent studies which were carried out with the CellDrum technology [2] and underline the added value to already existing standard procedures known from the field of physiology. Herein described CellDrum technology is a system to measure functional mechanical properties of cell monolayers and thin tissue constructs in-vitro. Additionally, the CellDrum enables to elucidate the mechanical response of cells to pharmacological drugs, toxins and vasoactive agents. Due to its highly flexible polymer support, cells can also be mechanically stimulated by steady and cyclic biaxial stretching.},
  language  = {en}
}
@article{TemizArtmannKurulgandemirciFıratetal.2021,
  author    = {Temiz Artmann, Ayseg{\"u}l and Kurulgan demirci, Eylem and F{\i}rat, Ipek Seda and Oflaz, Hakan and Artmann, Gerhard},
  title     = {Recombinant activated protein C (rhAPC) affects lipopolysaccharide-induced mechanical compliance changes and beat frequency of mESC-derived cardiomyocyte monolayers},
  series = {SHOCK},
  journal   = {SHOCK},
  publisher = {Wolters Kluwer},
  address   = {K{\"o}ln},
  issn      = {1540-0514},
  doi       = {10.1097/SHK.0000000000001845},
  year      = {2021},
  language  = {en}
}
@article{UysalCreutzFiratetal.2022,
  author    = {Uysal, Karya and Creutz, Till and Firat, Ipek Seda and Artmann, Gerhard and Teusch, Nicole and Temiz Artmann, Ayseg{\"u}l},
  title     = {Bio-functionalized ultra-thin, large-area and waterproof silicone membranes for biomechanical cellular loading and compliance experiments},
  series = {Polymers},
  volume    = {14},
  journal   = {Polymers},
  number    = {11},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2073-4360},
  pages     = {2213},
  year      = {2022},
  abstract  = {Biocompatibility, flexibility and durability make polydimethylsiloxane (PDMS) membranes top candidates in biomedical applications. CellDrum technology uses large area, <10 µm thin membranes as mechanical stress sensors of thin cell layers. For this to be successful, the properties (thickness, temperature, dust, wrinkles, etc.) must be precisely controlled. The following parameters of membrane fabrication by means of the Floating-on-Water (FoW) method were investigated: (1) PDMS volume, (2) ambient temperature, (3) membrane deflection and (4) membrane mechanical compliance. Significant differences were found between all PDMS volumes and thicknesses tested (p < 0.01). They also differed from the calculated values. At room temperatures between 22 and 26 °C, significant differences in average thickness values were found, as well as a continuous decrease in thicknesses within a 4 °C temperature elevation. No correlation was found between the membrane thickness groups (between 3-4 µm) in terms of deflection and compliance. We successfully present a fabrication method for thin bio-functionalized membranes in conjunction with a four-step quality management system. The results highlight the importance of tight regulation of production parameters through quality control. The use of membranes described here could also become the basis for material testing on thin, viscous layers such as polymers, dyes and adhesives, which goes far beyond biological applications.},
  language  = {en}
}
@article{BayerTemizArtmannDigeletal.2020,
  author    = {Bayer, Robin and Temiz Artmann, Ayseg{\"u}l and Digel, Ilya and Falkenstein, Julia and Artmann, Gerhard and Creutz, Till and Hescheler, J{\"u}rgen},
  title     = {Mechano-pharmacological testing of L-Type Ca²⁺ channel modulators via human vascular celldrum model},
  series = {Cellular Physiology and Biochemistry},
  volume    = {54},
  journal   = {Cellular Physiology and Biochemistry},
  publisher = {Cell Physiol Biochem Press},
  address   = {D{\"u}sseldorf},
  issn      = {1421-9778},
  doi       = {10.33594/000000225},
  pages     = {371 -- 383},
  year      = {2020},
  abstract  = {Background/Aims: This study aimed to establish a precise and well-defined working model, assessing pharmaceutical effects on vascular smooth muscle cell monolayer in-vitro. It describes various analysis techniques to determine the most suitable to measure the biomechanical impact of vasoactive agents by using CellDrum technology. Methods: The so-called CellDrum technology was applied to analyse the biomechanical properties of confluent human aorta muscle cells (haSMC) in monolayer. The cell generated tensions deviations in the range of a few N/m² are evaluated by the CellDrum technology. This study focuses on the dilative and contractive effects of L-type Ca²⁺ channel agonists and antagonists, respectively. We analyzed the effects of Bay K8644, nifedipine and verapamil. Three different measurement modes were developed and applied to determine the most appropriate analysis technique for the study purpose. These three operation modes are called, particular time mode" (PTM), "long term mode" (LTM) and "real-time mode" (RTM). Results: It was possible to quantify the biomechanical response of haSMCs to the addition of vasoactive agents using CellDrum technology. Due to the supplementation of 100nM Bay K8644, the tension increased approximately 10.6\% from initial tension maximum, whereas, the treatment with nifedipine and verapamil caused a significant decrease in cellular tension: 10nM nifedipine decreased the biomechanical stress around 6,5\% and 50nM verapamil by 2,8\%, compared to the initial tension maximum. Additionally, all tested measurement modes provide similar results while focusing on different analysis parameters. Conclusion: The CellDrum technology allows highly sensitive biomechanical stress measurements of cultured haSMC monolayers. The mechanical stress responses evoked by the application of vasoactive calcium channel modulators were quantified functionally (N/m²). All tested operation modes resulted in equal findings, whereas each mode features operation-related data analysis.},
  language  = {en}
}
@incollection{AzatKerimkulovaMansurovetal.2020,
  author    = {Azat, Seitkhan and Kerimkulova, Almagul R. and Mansurov, Zulkhair A. and Adekenov, Sergazy and Artmann, Gerhard},
  title     = {The Use of Fusicoccin as Anticancer Compound},
  series = {Carbon Nanomaterials in Biomedicine and the Environment},
  booktitle = {Carbon Nanomaterials in Biomedicine and the Environment},
  publisher = {Jenny Stanford Publishing},
  address   = {New York},
  isbn      = {978-0-429-42864-7},
  doi       = {10.1201/9780429428647-8},
  pages     = {149 -- 172},
  year      = {2020},
  abstract  = {The problem of creation and use of sorption materials is of current interest for the practice of the modern medicine and agriculture. Practical importance is production of a biostimulant using a carbon sorbent for a significant increase in productivity, which is very relevant for the regions of Kazakhstan. It is known that a plant phytohormone—fusicoccin—in nanogram concentrations transforms cancer cells to the state of apoptosis. In this regard, there is a scientific practical interest in the development of a highly efficient method for producing fusicoccin from extract of germinated wheat seeds. According to the results of computer modeling, cleaning composite components of fusicoccin using microporous carbon adsorbents not suitable as the size of the molecule of fusicoccin more than micropores and the optimum pore size for purification of constituents of fusicoccin was determined by computer simulation.},
  language  = {en}
}
@techreport{Artmann2011,
  author    = {Artmann, Gerhard},
  title     = {HPBioforce: Integrierte und automatisierte Screening Plattform eines 96-Well-Hochdurchsatz-Testsystems zur funktionellen Kraftmessung an einige um dicken Zell- und Gewebeschichten f{\"u}r die Arzneimittelforschung : gemeinsamer Abschlussbericht der FH Aachen, Hitec Zang GmbH, IKFE Mainz, IKFE Berlin und der Dr. Gerhard Schmidt GmbH zum InnoNet-Projekt ... ; Programm "F{\"o}rderung von innovativen Netzwerken" (InnoNet) des Bundesministerium f{\"u}r Wirtschaft und Technologie (BMWi) ; Laufzeit: 01.05.2007 bis 31.12.2010},
  publisher = {Technische Informationsbibliothek u. Universit{\"a}tsbibliothek},
  address   = {Aachen [u.a.]},
  doi       = {10.2314/GBV:68757076X},
  year      = {2011},
  language  = {de}
}
@techreport{Artmann2011,
  author    = {Artmann, Gerhard},
  title     = {FhprofUnd EasyBioforce Abschlussbericht : Miniaturisierte, integrierte und automatisierte Screening Plattform eines 36-Well-Hochdurchsatz-Testsystems zur funktionellen Kraftmessung an Zell- und Gewebeschichten f{\"u}r die Arzneimittelforschung : Laufzeit des Vorhabens: 01.03.2007 - 31.12.2010},
  publisher = {Technische Informationsbibliothek u. Universit{\"a}tsbibliothek},
  address   = {Aachen},
  doi       = {10.2314/GBV:782964621},
  year      = {2011},
  language  = {de}
}
@techreport{Artmann2004,
  author    = {Artmann, Gerhard},
  title     = {Escherichia Coli Infektion und Zellsch{\"a}digung - Wie perfekt wirken Antibiotika? : Abschlussbericht zum Projekt 1703701},
  publisher = {Technische Informationsbibliothek u. Universit{\"a}tsbibliothek},
  address   = {J{\"u}lich},
  doi       = {10.2314/GBV:482527137},
  year      = {2004},
  language  = {de}
}
@techreport{Artmann2011,
  author    = {Artmann, Gerhard},
  title     = {Plant mutant scanner : Hochdurchsatzscanner zur Charakterisierung von Pflanzenmutanten. Abschlussbericht ; FHprofUnd ; PhytoScan ; Laufzeit des Vorhabens: 01.07.2008 - 30.06.2011},
  publisher = {Technische Informationsbibliothek u. Universit{\"a}tsbibliothek},
  address   = {Aachen},
  doi       = {10.2314/GBV:747569150},
  year      = {2011},
  language  = {de}
}