@article{BreussKleefeld2020, author = {Breuß, Michael and Kleefeld, Andreas}, title = {Implicit monotone difference methods for scalar conservation laws with source terms}, series = {Acta Mathematica Vietnamica}, volume = {45}, journal = {Acta Mathematica Vietnamica}, publisher = {Springer Singapore}, address = {Singapore}, issn = {2315-4144}, doi = {10.1007/s40306-019-00354-1}, pages = {709 -- 738}, year = {2020}, abstract = {In this article, a concept of implicit methods for scalar conservation laws in one or more spatial dimensions allowing also for source terms of various types is presented. This material is a significant extension of previous work of the first author (Breuß SIAM J. Numer. Anal. 43(3), 970-986 2005). Implicit notions are developed that are centered around a monotonicity criterion. We demonstrate a connection between a numerical scheme and a discrete entropy inequality, which is based on a classical approach by Crandall and Majda. Additionally, three implicit methods are investigated using the developed notions. Next, we conduct a convergence proof which is not based on a classical compactness argument. Finally, the theoretical results are confirmed by various numerical tests.}, language = {en} } @incollection{BrittenBraunHesseetal.2003, author = {Britten, G. and Braun, Carsten and Hesse, M. and Ballmann, Josef}, title = {Computational aeroelasticity with reduced structural models}, series = {Flow modulation and fluid-structure interaction at airplane wings : research results of the Collaborative Research Center SFB 401 at RWTH Aachen, University of Technology, Aachen, Germany / Josef Ballmann (Ed.) Notes on numerical fluid mechanics and multidisciplinary design. Vol. 84}, booktitle = {Flow modulation and fluid-structure interaction at airplane wings : research results of the Collaborative Research Center SFB 401 at RWTH Aachen, University of Technology, Aachen, Germany / Josef Ballmann (Ed.) Notes on numerical fluid mechanics and multidisciplinary design. Vol. 84}, publisher = {Springer}, address = {Berlin}, isbn = {3-540-40209-8}, pages = {275 -- 299}, year = {2003}, language = {en} } @article{BrockhausBehbahaniMurisetal.2021, author = {Brockhaus, Moritz K. and Behbahani, Mehdi and Muris, Farina and Jansen, Sebastian V. and Schmitz- Rode, Thomas and Steinseifer, Ulrich and Clauser, Johanna C.}, title = {In vitro thrombogenicity testing of pulsatile mechanical circulatory support systems: Design and proof-of-concept}, series = {Artificial Organs}, volume = {45}, journal = {Artificial Organs}, number = {12}, publisher = {Wiley}, address = {Weinheim}, issn = {1525-1594}, doi = {10.1111/aor.14046}, pages = {1513 -- 1521}, year = {2021}, abstract = {Thrombogenic complications are a main issue in mechanical circulatory support (MCS). There is no validated in vitro method available to quantitatively assess the thrombogenic performance of pulsatile MCS devices under realistic hemodynamic conditions. The aim of this study is to propose a method to evaluate the thrombogenic potential of new designs without the use of complex in-vivo trials. This study presents a novel in vitro method for reproducible thrombogenicity testing of pulsatile MCS systems using low molecular weight heparinized porcine blood. Blood parameters are continuously measured with full blood thromboelastometry (ROTEM; EXTEM, FIBTEM and a custom-made analysis HEPNATEM). Thrombus formation is optically observed after four hours of testing. The results of three experiments are presented each with two parallel loops. The area of thrombus formation inside the MCS device was reproducible. The implantation of a filter inside the loop catches embolizing thrombi without a measurable increase of platelet activation, allowing conclusions of the place of origin of thrombi inside the device. EXTEM and FIBTEM parameters such as clotting velocity (α) and maximum clot firmness (MCF) show a total decrease by around 6\% with a characteristic kink after 180 minutes. HEPNATEM α and MCF rise within the first 180 minutes indicate a continuously increasing activation level of coagulation. After 180 minutes, the consumption of clotting factors prevails, resulting in a decrease of α and MCF. With the designed mock loop and the presented protocol we are able to identify thrombogenic hot spots inside a pulsatile pump and characterize their thrombogenic potential.}, language = {en} } @inproceedings{BrockmannSultanowCzarnecki2019, author = {Brockmann, Carsten and Sultanow, Eldar and Czarnecki, Christian}, title = {Is enterprise architecture still relevant in the digital age?}, series = {GI Edition Proceedings Band 295 INFORMATIK 2019, Workshop-Beitr{\"a}ge}, booktitle = {GI Edition Proceedings Band 295 INFORMATIK 2019, Workshop-Beitr{\"a}ge}, editor = {Draude, Claude and Lange, Martin and Sick, Bernhard}, publisher = {K{\"o}llen}, address = {Bonn}, isbn = {9783885796893}, issn = {1617-5468}, doi = {10.18420/inf2019_ws01}, pages = {21 -- 21}, year = {2019}, language = {en} } @inproceedings{BrockmannSultanowCzarnecki2018, author = {Brockmann, Carsten and Sultanow, Eldar and Czarnecki, Christian}, title = {Enterprise architectures between agility and traditional methodologies}, series = {GI Edition Proceedings Band 285 Workshops der INFORMATIK 2018}, booktitle = {GI Edition Proceedings Band 285 Workshops der INFORMATIK 2018}, editor = {Czarnecki, Christian and Brockmann, Carsten and Sultanow, Eldar and Koschmider, Agnes and Selzer, Annika and Gesellschaft f{\"u}r Informatik e. V.,}, publisher = {K{\"o}llen}, address = {Bonn}, isbn = {9783885796794}, issn = {1617-5468}, pages = {1 Seite}, year = {2018}, abstract = {For this year's workshop on Enterpirse Architecture in Research and Practice we have received eight submissions from which four have passed the rigorous peer-review. The acceptance quote of 50\% assures that only advancements in the field are included in our workshop.}, language = {en} } @inproceedings{BroennerHoefkenSchuba2016, author = {Broenner, Simon and H{\"o}fken, Hans-Wilhelm and Schuba, Marko}, title = {Streamlining extraction and analysis of android RAM images}, series = {Proceedings of the 2nd international conference on information systems security and privacy}, booktitle = {Proceedings of the 2nd international conference on information systems security and privacy}, organization = {ICISSP International Conference on Information Systems Security and Privacy <2, 2016, Rome, Italy>}, isbn = {978-989-758-167-0}, doi = {10.5220/0005652802550264}, pages = {255 -- 264}, year = {2016}, language = {en} } @phdthesis{Bronder2020, author = {Bronder, Thomas}, title = {Label-free detection of tuberculosis DNA with capacitive field-effect biosensors}, publisher = {Philipps-Universit{\"a}t Marburg}, address = {Marburg}, doi = {10.17192/z2021.0056}, pages = {X, 162 S}, year = {2020}, language = {en} } @article{BronderJessingPoghossianetal.2018, author = {Bronder, Thomas and Jessing, Max P. and Poghossian, Arshak and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Detection of PCR-Amplified Tuberculosis DNA Fragments with Polyelectrolyte-Modified Field-Effect Sensors}, series = {Analytical Chemistry}, volume = {90}, journal = {Analytical Chemistry}, number = {12}, publisher = {ACS Publications}, address = {Washington, DC}, issn = {0003-2700}, doi = {10.1021/acs.analchem.8b01807}, pages = {7747 -- 7753}, year = {2018}, abstract = {Field-effect-based electrolyte-insulator-semiconductor (EIS) sensors were modified with a bilayer of positively charged weak polyelectrolyte (poly(allylamine hydrochloride) (PAH)) and probe single-stranded DNA (ssDNA) and are used for the detection of complementary single-stranded target DNA (cDNA) in different test solutions. The sensing mechanism is based on the detection of the intrinsic molecular charge of target cDNA molecules after the hybridization event between cDNA and immobilized probe ssDNA. The test solutions contain synthetic cDNA oligonucleotides (with a sequence of tuberculosis mycobacteria genome) or PCR-amplified DNA (which origins from a template DNA strand that has been extracted from Mycobacterium avium paratuberculosis-spiked human sputum samples), respectively. Sensor responses up to 41 mV have been measured for the test solutions with DNA, while only small signals of ∼5 mV were detected for solutions without DNA. The lower detection limit of the EIS sensors was ∼0.3 nM, and the sensitivity was ∼7.2 mV/decade. Fluorescence experiments using SybrGreen I fluorescence dye support the electrochemical results.}, language = {en} } @article{BronderPoghossianJessingetal.2019, author = {Bronder, Thomas and Poghossian, Arshak and Jessing, Max P. and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Surface regeneration and reusability of label-free DNA biosensors based on weak polyelectrolyte-modified capacitive field-effect structures}, series = {Biosensors and Bioelectronics}, volume = {126}, journal = {Biosensors and Bioelectronics}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0956-5663}, doi = {10.1016/j.bios.2018.11.019}, pages = {510 -- 517}, year = {2019}, language = {en} } @article{BronderPoghossianKeusgenetal.2017, author = {Bronder, Thomas and Poghossian, Arshak and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Label-free detection of double-stranded DNA molecules with polyelectrolyte-modified capacitive field-effect sensors}, series = {tm - Technisches Messen}, volume = {84}, journal = {tm - Technisches Messen}, number = {10}, publisher = {De Gruyter}, address = {Oldenbourg}, doi = {10.1515/teme-2017-0015}, pages = {628 -- 634}, year = {2017}, abstract = {In this study, polyelectrolyte-modified field-effect-based electrolyte-insulator-semiconductor (EIS) devices have been used for the label-free electrical detection of double-stranded deoxyribonucleic acid (dsDNA)molecules. The sensor-chip functionalization with a positively charged polyelectrolyte layer provides the possibility of direct adsorptive binding of negatively charged target DNA oligonucleotides onto theSiO2-chip surface.EIS sensors can be utilized as a tool to detect surface-charge changes; the electrostatic adsorption of oligonucleotides onto the polyelectrolyte layer leads to a measureable surface-potential change. Signals of 39mV have been recorded after the incubation with the oligonucleotide solution. Besides the electrochemical experiments, the successful adsorption of dsDNA onto the polyelectrolyte layer has been verified via fluorescence microscopy. The presented results demonstrate that the signal recording of EISchips, which are modified with a polyelectrolyte layer, canbe used as a favorable approach for a fast, cheap and simple detection method for dsDNA.}, language = {en} }