@masterthesis{Heising2023, type = {Bachelor Thesis}, author = {Heising, Michelle}, title = {Nachhaltige Gestaltung im urbanen {\"o}ffentlichen Raum : erneuerbare Energien in Begegnungsr{\"a}ume integrieren}, publisher = {FH Aachen}, address = {Aachen}, pages = {83 Seiten}, year = {2023}, abstract = {RƎURB (Reurbanization \& Renewable Energy) ist ein Konzept zur Integration von erneuerbaren Energien in einen urbanen Begegnungsraum. Es beinhaltet das Design eines skulpturalen Kleinwindkraftwerks und eines Solar-Pavillons mit einer Sitzlandschaft f{\"u}r einen energieautarken, {\"o}ffentlichen Platz. Durch die Integration eines W-LAN Hotspots und Ladem{\"o}glichkeiten in der Sitzlandschaft bringt RƎURB nicht nur gr{\"u}nen Strom in die Stadt, sondern gew{\"a}hrleistet der Bev{\"o}lkerung auch Zugang zur Digitalisierung und einen kostenlosen Arbeitsraum. Windturbine: Herk{\"o}mmliche Windr{\"a}der k{\"o}nnen in der Stadt nicht genutzt werden. Die RƎURB-Winds{\"a}ule ist darauf spezialisiert, die urbanen Winde aus allen Richtungen aufzunehmen und funktioniert schon bei einem leichten Windstoß. Durch das elegante Design lassen sich die Technologien als {\"a}sthetischen Blickfang in das moderne Stadtbild integrieren.}, language = {de} } @masterthesis{Heindrichs2023, type = {Bachelor Thesis}, author = {Heindrichs, Maik}, title = {Intrinsic Motion in Type : eine Bewegtbild Plakatreihe f{\"u}r das D{\"u}sseldorfer Schauspielhaus}, publisher = {FH Aachen}, address = {Aachen}, pages = {53 Seiten}, year = {2023}, abstract = {Gestaltung und Programmierung dynamischer Motion-Design Plakate zwecks Kommunikation der Theaterst{\"u}cke des D{\"u}sseldorfer Schauspielhauses. Der Fokus liegt dabei auf der Typografie und ihrer intrinsischen Bewegung. Der technische Fortschritt bietet viele neue M{\"o}glichkeiten im Umgang mit Schrift. Diese Arbeit dient dazu, mithilfe von aktuellen Techniken einen neuen Ansatz im Bereich Gestaltung mit Schrift, sowie Variable Fonts, in Kombination mit Motion-Design aufzuzeigen. Dies wird anhand von Eigenschaften der Schrift und der inhaltlichen Ebene, ohne die Buchstaben dabei zu dekonstruieren, umgesetzt. Die Bewegungen werden dann in das Format Plakat {\"u}bertragen und dargestellt.}, language = {de} } @incollection{HeimesKampkerKehreretal.2023, author = {Heimes, Heiner Hans and Kampker, Achim and Kehrer, Mario and D{\"u}nnwald, Simon and Heetfeld, Lennart and Polzenberg, Jens and Budde, Lucas and Keusen, Maximilian and Pandey, Rahul and R{\"o}th, Thilo}, title = {Fahrzeugstruktur}, series = {Elektromobilit{\"a}t: Grundlagen einer Fortschrittstechnologie}, booktitle = {Elektromobilit{\"a}t: Grundlagen einer Fortschrittstechnologie}, editor = {Kampker, Achim and Heimes, Heiner Hans}, publisher = {Springer Vieweg}, address = {Berlin}, isbn = {978-3-662-65811-6 (Print)}, doi = {10.1007/978-3-662-65812-3_5}, pages = {69 -- 106}, year = {2023}, abstract = {Um sowohl Treibhausgas-Emissionen zu verringern als auch Kraftstoffressourcen zu schonen, wird zunehmend an einer Transformation konventionell angetriebener Kraftfahrzeuge hin zu elektrifizierten Antriebskonzepten gearbeitet. Basierend auf herk{\"o}mmlichen Fahrzeugen mit Verbrennungsmotor wurde eine Vielzahl neuer Antriebssysteme mit verschiedenem Elektrifizierungsgrad entwickelt. Mitte der 1990er-Jahre kamen erste Fahrzeuge mit einem Hybridantrieb auf den Markt. Die Kombination aus Verbrennungs- und Elektromotor erlaubt eine Verbrauchsreduktion und Bremsenergier{\"u}ckgewinnung sowie lokal emissionsfreies Fahren.}, language = {de} } @incollection{HeimesKampkerDornetal.2023, author = {Heimes, Heiner Hans and Kampker, Achim and Dorn, Benjamin and Kehrer, Mario and D{\"u}nnwald, Simon and Badura, Dennis and Terren, Maximilian and R{\"o}th, Thilo}, title = {Produktionsprozesse der Fahrzeugstruktur}, series = {Elektromobilit{\"a}t: Grundlagen einer Fortschrittstechnologie}, booktitle = {Elektromobilit{\"a}t: Grundlagen einer Fortschrittstechnologie}, editor = {Kampker, Achim and Heimes, Heiner Hans}, publisher = {Springer Vieweg}, address = {Berlin}, isbn = {978-3-662-65811-6 (Print)}, doi = {10.1007/978-3-662-65812-3_13}, pages = {227 -- 247}, year = {2023}, language = {de} } @article{HeieisBoeckerD'Angeloetal.2023, author = {Heieis, Jule and B{\"o}cker, Jonas and D'Angelo, Olfa and Mittag, Uwe and Albracht, Kirsten and Sch{\"o}nau, Eckhard and Meyer, Andreas and Voigtmann, Thomas and Rittweger, J{\"o}rn}, title = {Curvature of gastrocnemius muscle fascicles as function of muscle-tendon complex length and contraction in humans}, series = {Physiological Reports}, volume = {11}, journal = {Physiological Reports}, number = {11}, publisher = {Wiley}, issn = {2051-817X}, doi = {10.14814/phy2.15739}, pages = {e15739, Seite 1-11}, year = {2023}, abstract = {It has been shown that muscle fascicle curvature increases with increasing contraction level and decreasing muscle-tendon complex length. The analyses were done with limited examination windows concerning contraction level, muscle-tendon complex length, and/or intramuscular position of ultrasound imaging. With this study we aimed to investigate the correlation between fascicle arching and contraction, muscle-tendon complex length and their associated architectural parameters in gastrocnemius muscles to develop hypotheses concerning the fundamental mechanism of fascicle curving. Twelve participants were tested in five different positions (90°/105°*, 90°/90°*, 135°/90°*, 170°/90°*, and 170°/75°*; *knee/ankle angle). They performed isometric contractions at four different contraction levels (5\%, 25\%, 50\%, and 75\% of maximum voluntary contraction) in each position. Panoramic ultrasound images of gastrocnemius muscles were collected at rest and during constant contraction. Aponeuroses and fascicles were tracked in all ultrasound images and the parameters fascicle curvature, muscle-tendon complex strain, contraction level, pennation angle, fascicle length, fascicle strain, intramuscular position, sex and age group were analyzed by linear mixed effect models. Mean fascicle curvature of the medial gastrocnemius increased with contraction level (+5 m-1 from 0\% to 100\%; p = 0.006). Muscle-tendon complex length had no significant impact on mean fascicle curvature. Mean pennation angle (2.2 m-1 per 10°; p < 0.001), inverse mean fascicle length (20 m-1 per cm-1; p = 0.003), and mean fascicle strain (-0.07 m-1 per +10\%; p = 0.004) correlated with mean fascicle curvature. Evidence has also been found for intermuscular, intramuscular, and sex-specific intramuscular differences of fascicle curving. Pennation angle and the inverse fascicle length show the highest predictive capacities for fascicle curving. Due to the strong correlations between pennation angle and fascicle curvature and the intramuscular pattern of curving we suggest for future studies to examine correlations between fascicle curvature and intramuscular fluid pressure.}, language = {en} } @masterthesis{Hatke2023, type = {Bachelor Thesis}, author = {Hatke, Lars}, title = {X Plore: human hybrid submarine}, publisher = {FH Aachen}, address = {Aachen}, pages = {153 Seiten}, year = {2023}, abstract = {Das „X Plore" ist ein human hybrid angetriebenes Tauchboot, welches sowohl f{\"u}r den touristischen als auch privaten Gebrauch konzipiert ist. Das immersive Design des „X Plore" sorgt f{\"u}r ein eindrucksvolles Taucherlebnis. Das Konzept soll die Menschen {\"u}ber die aktuelle Not der Meere und ihrer Lebewesen aufkl{\"a}ren und ihnen gleichzeitig die M{\"o}glichkeit geben, der Unterwasserwelt n{\"a}her zukommen. Zudem soll es diese erhalten und ihre Bewohner:innen sch{\"u}tzen. Des Weiteren thematisiert die Arbeit zukunftsorientierte Antriebs- und Batterietechniken und setzt sich mit der sinnvollen Integrierung dieser auseinander.}, language = {de} } @article{HaegerGrankinWagner2023, author = {Haeger, Gerrit and Grankin, Alina and Wagner, Michaela}, title = {Construction of an Aspergillus oryzae triple amylase deletion mutant as a chassis to evaluate industrially relevant amylases using multiplex CRISPR/Cas9 editing technology}, series = {Applied Research}, journal = {Applied Research}, number = {Early View}, publisher = {Wiley-VCH}, issn = {2702-4288}, doi = {10.1002/appl.202200106}, pages = {1 -- 15}, year = {2023}, abstract = {Aspergillus oryzae is an industrially relevant organism for the secretory production of heterologous enzymes, especially amylases. The activities of potential heterologous amylases, however, cannot be quantified directly from the supernatant due to the high background activity of native α-amylase. This activity is caused by the gene products of amyA, amyB, and amyC. In this study, an in vitro CRISPR/Cas9 system was established in A. oryzae to delete these genes simultaneously. First, pyrG of A. oryzae NSAR1 was mutated by exploiting NHEJ to generate a counter-selection marker. Next, all amylase genes were deleted simultaneously by co-transforming a repair template carrying pyrG of Aspergillus nidulans and flanking sequences of amylase gene loci. The rate of obtained triple knock-outs was 47\%. We showed that triple knockouts do not retain any amylase activity in the supernatant. The established in vitro CRISPR/Cas9 system was used to achieve sequence-specific knock-in of target genes. The system was intended to incorporate a single copy of the gene of interest into the desired host for the development of screening methods. Therefore, an integration cassette for the heterologous Fpi amylase was designed to specifically target the amyB locus. The site-specific integration rate of the plasmid was 78\%, with exceptional additional integrations. Integration frequency was assessed via qPCR and directly correlated with heterologous amylase activity. Hence, we could compare the efficiency between two different signal peptides. In summary, we present a strategy to exploit CRISPR/Cas9 for gene mutation, multiplex knock-out, and the targeted knock-in of an expression cassette in A. oryzae. Our system provides straightforward strain engineering and paves the way for development of fungal screening systems.}, language = {en} } @techreport{HaegerBongaertsSiegert2023, author = {Haeger, Gerrit and Bongaerts, Johannes and Siegert, Petra}, title = {Abschlussbericht Teil II: Eingehende Darstellung Neue biobasierte Lipopeptide aus nachhaltiger Produktion (LipoPep)}, pages = {17Seiten}, year = {2023}, language = {de} } @inproceedings{GrundAltherr2023, author = {Grund, Raphael M. and Altherr, Lena}, title = {Development of an open source energy disaggregation tool for the home automation platform Home Assistant}, series = {Tagungsband AALE 2023 : mit Automatisierung gegen den Klimawandel}, booktitle = {Tagungsband AALE 2023 : mit Automatisierung gegen den Klimawandel}, editor = {Reiff-Stephan, J{\"o}rg and J{\"a}kel, Jens and Schwarz, Andr{\´e}}, publisher = {le-tex publishing services GmbH}, address = {Leipzig}, isbn = {978-3-910103-01-6}, doi = {10.33968/2023.02}, pages = {11 -- 20}, year = {2023}, abstract = {In order to reduce energy consumption of homes, it is important to make transparent which devices consume how much energy. However, power consumption is often only monitored aggregated at the house energy meter. Disaggregating this power consumption into the contributions of individual devices can be achieved using Machine Learning. Our work aims at making state of the art disaggregation algorithms accessibe for users of the open source home automation platform Home Assistant.}, language = {en} } @unpublished{GreinerJerominSitholeetal.2023, author = {Greiner, Lasse and Jeromin, G{\"u}nter Erich and Sithole, Patience and Petersen, Soenke}, title = {Preprint: Studies on the enzymatic reduction of levulinic acid using Chiralidon-R and Chiralidon-S}, series = {ChemRxiv}, journal = {ChemRxiv}, doi = {10.26434/chemrxiv-2023-jlvcv}, pages = {13 Seiten}, year = {2023}, abstract = {The enzymatic reduction of levulinic acid by the chiral catalysts Chiralidon-R and Chiralidon-S which are commercially available superabsorbed alcohol dehydrogenases is described. The Chiralidon®-R/S reduces the levulinic acid to the (R,S)-4-hydroxy valeric acid and the (R)- or (S)- gamma-valerolactone.}, language = {en} }