@article{MonakhovaSobolevaFedotovaetal.2022,
  author    = {Monakhova, Yulia and Soboleva, Polina M. and Fedotova, Elena S. and Musina, Kristina T. and Burmistrova, Natalia A.},
  title     = {Quantum chemical calculations of IR spectra of heparin disaccharide subunits},
  series = {Computational and Theoretical Chemistry},
  volume    = {1217},
  journal   = {Computational and Theoretical Chemistry},
  number    = {Article number: 113891},
  publisher = {Elsevier},
  address   = {New York, NY},
  isbn      = {2210-271X},
  doi       = {10.1016/j.comptc.2022.113891},
  year      = {2022},
  abstract  = {Heparin is a natural polysaccharide, which plays essential role in many biological processes. Alterations in building blocks can modify biological roles of commercial heparin products, due to significant changes in the conformation of the polymer chain. The variability structure of heparin leads to difficulty in quality control using different analytical methods, including infrared (IR) spectroscopy. In this paper molecular modelling of heparin disaccharide subunits was performed using quantum chemistry. The structural and spectral parameters of these disaccharides have been calculated using RHF/6-311G. In addition, over-sulphated chondroitin sulphate disaccharide was studied as one of the most widespread contaminants of heparin. Calculated IR spectra were analyzed with respect to specific structure parameters. IR spectroscopic fingerprint was found to be sensitive to substitution pattern of disaccharide subunits. Vibrational assignments of calculated spectra were correlated with experimental IR spectral bands of native heparin. Chemometrics was used to perform multivariate analysis of simulated spectral data.},
  language  = {en}
}
@article{MonakhovaDiehl2022,
  author    = {Monakhova, Yulia and Diehl, Bernd W.K.},
  title     = {Nuclear magnetic resonance spectroscopy as an elegant tool for a complete quality control of crude heparin material},
  series = {Journal of Pharmaceutical and Biomedical Analysis},
  volume    = {219},
  journal   = {Journal of Pharmaceutical and Biomedical Analysis},
  number    = {Article number: 114915},
  publisher = {Elsevier},
  address   = {New York, NY},
  issn      = {0731-7085},
  doi       = {10.1016/j.jpba.2022.114915},
  year      = {2022},
  abstract  = {Nuclear magnetic resonance (NMR) spectrometric methods for the quantitative analysis of pure heparin in crude heparin is proposed. For quantification, a two-step routine was developed using a USP heparin reference sample for calibration and benzoic acid as an internal standard. The method was successfully validated for its accuracy, reproducibility, and precision. The methodology was used to analyze 20 authentic porcine heparinoid samples having heparin content between 4.25 w/w \% and 64.4 w/w \%. The characterization of crude heparin products was further extended to a simultaneous analysis of these common ions: sodium, calcium, acetate and chloride. A significant, linear dependence was found between anticoagulant activity and assayed heparin content for thirteen heparinoids samples, for which reference data were available. A Diffused-ordered NMR experiment (DOSY) can be used for qualitative analysis of specific glycosaminoglycans (GAGs) in heparinoid matrices and, potentially, for quantitative prediction of molecular weight of GAGs. NMR spectrometry therefore represents a unique analytical method suitable for the simultaneous quantitative control of organic and inorganic composition of crude heparin samples (especially heparin content) as well as an estimation of other physical and quality parameters (molecular weight, animal origin and activity).},
  language  = {en}
}
@article{MonakhovaDiehl2022,
  author    = {Monakhova, Yulia and Diehl, Bernd W.K.},
  title     = {Multinuclear NMR screening of pharmaceuticals using standardization by 2H integral of a deuterated solvent},
  series = {Journal of Pharmaceutical and Biomedical Analysis},
  volume    = {209},
  journal   = {Journal of Pharmaceutical and Biomedical Analysis},
  number    = {Article number: 114530},
  publisher = {Elsevier},
  isbn      = {0731-7085},
  doi       = {10.1016/j.jpba.2021.114530},
  year      = {2022},
  abstract  = {NMR standardization approach that uses the 2H integral of deuterated solvent for quantitative multinuclear analysis of pharmaceuticals is described. As a proof of principle, the existing NMR procedure for the analysis of heparin products according to US Pharmacopeia monograph is extended to the determination of Na+ and Cl- content in this matrix. Quantification is performed based on the ratio of a 23Na (35Cl) NMR integral and 2H NMR signal of deuterated solvent, D2O, acquired using the specific spectrometer hardware. As an alternative, the possibility of 133Cs standardization using the addition of Cs2CO3 stock solution is shown. Validation characteristics (linearity, repeatability, sensitivity) are evaluated. A holistic NMR profiling of heparin products can now also be used for the quantitative determination of inorganic compounds in a single analytical run using a single sample. In general, the new standardization methodology provides an appealing alternative for the NMR screening of inorganic and organic components in pharmaceutical products.},
  language  = {en}
}
@article{MolinnusJanusFangetal.2022,
  author    = {Molinnus, Denise and Janus, Kevin Alexander and Fang, Anyelina C. and Drinic, Aleksander and Achtsnicht, Stefan and K{\"o}pf, Marius and Keusgen, Michael and Sch{\"o}ning, Michael Josef},
  title     = {Thick-film carbon electrode deposited onto a biodegradable fibroin substrate for biosensing applications},
  series = {Physica status solidi (a)},
  volume    = {219},
  journal   = {Physica status solidi (a)},
  number    = {23},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1862-6319},
  doi       = {10.1002/pssa.202200100},
  pages     = {1 -- 9},
  year      = {2022},
  abstract  = {This study addresses a proof-of-concept experiment with a biocompatible screen-printed carbon electrode deposited onto a biocompatible and biodegradable substrate, which is made of fibroin, a protein derived from silk of the Bombyx mori silkworm. To demonstrate the sensor performance, the carbon electrode is functionalized as a glucose biosensor with the enzyme glucose oxidase and encapsulated with a silicone rubber to ensure biocompatibility of the contact wires. The carbon electrode is fabricated by means of thick-film technology including a curing step to solidify the carbon paste. The influence of the curing temperature and curing time on the electrode morphology is analyzed via scanning electron microscopy. The electrochemical characterization of the glucose biosensor is performed by amperometric/voltammetric measurements of different glucose concentrations in phosphate buffer. Herein, systematic studies at applied potentials from 500 to 1200 mV to the carbon working electrode (vs the Ag/AgCl reference electrode) allow to determine the optimal working potential. Additionally, the influence of the curing parameters on the glucose sensitivity is examined over a time period of up to 361 days. The sensor shows a negligible cross-sensitivity toward ascorbic acid, noradrenaline, and adrenaline. The developed biocompatible biosensor is highly promising for future in vivo and epidermal applications.},
  language  = {en}
}
@article{MolinnusIkenJohnenetal.2022,
  author    = {Molinnus, Denise and Iken, Heiko and Johnen, Anna Lynn and Richstein, Benjamin and Hellmich, Lena and Poghossian, Arshak and Knoch, Joachim and Sch{\"o}ning, Michael Josef},
  title     = {Miniaturized pH-Sensitive Field-Effect Capacitors with Ultrathin Ta₂O₅ Films Prepared by Atomic Layer Deposition},
  series = {physica status solidi (a) applications and materials science},
  volume    = {219},
  journal   = {physica status solidi (a) applications and materials science},
  number    = {8},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1862-6319},
  doi       = {10.1002/pssa.202100660},
  pages     = {7 Seiten},
  year      = {2022},
  abstract  = {Miniaturized electrolyte-insulator-semiconductor capacitors (EISCAPs) with ultrathin gate insulators have been studied in terms of their pH-sensitive sensor characteristics: three different EISCAP systems consisting of Al-p-Si-Ta2O5(5 nm), Al-p-Si-Si3N4(1 or 2 nm)-Ta2O5 (5 nm), and Al-p-Si-SiO2(3.6 nm)-Ta2O5(5 nm) layer structures are characterized in buffer solution with different pH values by means of capacitance-voltage and constant capacitance method. The SiO2 and Si3N4 gate insulators are deposited by rapid thermal oxidation and rapid thermal nitridation, respectively, whereas the Ta2O5 film is prepared by atomic layer deposition. All EISCAP systems have a clear pH response, favoring the stacked gate insulators SiO2-Ta2O5 when considering the overall sensor characteristics, while the Si3N4(1 nm)-Ta2O5 stack delivers the largest accumulation capacitance (due to the lower equivalent oxide thickness) and a higher steepness in the slope of the capacitance-voltage curve among the studied stacked gate insulator systems.},
  language  = {en}
}
@inproceedings{MilijašŠakićMarinkovićetal.2022,
  author    = {Milijaš, Aleksa and Šakić, Bogdan and Marinković, Marko and Butenweg, Christoph and Gams, Matija and Klinkel, Sven},
  title     = {Effects of prior in-plane damage on out-of-plane response of masonry infills with openings},
  series = {The Third European Conference on Earthquake Engineering and Seismology September 4 - September 9, 2022, Bucharest},
  booktitle = {The Third European Conference on Earthquake Engineering and Seismology September 4 - September 9, 2022, Bucharest},
  editor    = {Arion, Cristian and Scupin, Alexandra and Ţigănescu, Alexandru},
  isbn      = {978-973-100-533-1},
  pages     = {2747 -- 2756},
  year      = {2022},
  abstract  = {Masonry infill walls are the most traditional enclosure system that is still widely used in RC frame buildings all over the world, particularly in seismic active regions. Although infill walls are usually neglected in seismic design, during an earthquake event they are subjected to in-plane and out-of-plane forces that can act separately or simultaneously. Since observations of damage to buildings after recent earthquakes showed detrimental effects of in-plane and out-of-plane load interaction on infill walls, the number of studies that focus on influence of in-plane damage on out-of-plane response has significantly increased. However, most of the xperimental campaigns have considered only solid infills and there is a lack of combined in-plane and out-of-plane experimental tests on masonry infills with openings, although windows and doors strongly affect seismic performance. In this paper, two types of experimental tests on infills with window openings are presented. The first is a pure out-of-plane test and the second one is a sequential in-plane and out-of-plane test aimed at investigating the effects of existing in-plane damage on outof-plane response. Additionally, findings from two tests with similar load procedure that were carried out on fully infilled RC frames in the scope of the same project are used for comparison. Test results clearly show that window opening increased vulnerability of infills to combined seismic actions and that prevention of damage in infills with openings is of the utmost importance for seismic safety.},
  language  = {en}
}
@masterthesis{MeyerVanderSteeg2022,
  type      = {Bachelor Thesis},
  author    = {Meyer, Laura and Van der Steeg, Yasmeena},
  title     = {Heimat : ein interaktives und informatives Erlebnis zur individuellen Definition von Heimat},
  publisher = {FH Aachen},
  address   = {Aachen},
  school      = {Fachhochschule Aachen},
  pages     = {107 Seiten},
  year      = {2022},
  abstract  = {"Heimat" - Ein Begriff, der in den vergangenen Jahren wieder an Brisanz gewonnen hat. Die aktuelle Definition im Duden beschreibt ihn als Geburts- oder Wohnort. Aber hat Heimat wirklich nur eine Definition? Durch ein begehbares Erlebnis werden die Betrachter:Innen Schritt f{\"u}r Schritt an den Heimatbegriff herangef{\"u}hrt. Neben der aktuellen Defintion werden sie {\"u}ber den Wandel des Heimatbegriffs und seiner Bedeutung in der Geschichte der letzten Jahrhunderte aufgekl{\"a}rt. Dar{\"u}ber hinaus k{\"o}nnen sie andere Heimaten entdecken und im Anschluss an einem interaktiven Tisch spielerisch eigene Heimatdefinitionen finden und sie mit denen der Anderen vergleichen. Die Arbeit soll veranschaulichen, wie individuell der Heimatbegriff ist und dass sich eben hinter jeder sogenannten Heimat eine ganz pers{\"o}nliche Geschichte verbirgt.},
  language  = {de}
}
@inproceedings{MertensBraunerBaieretal.2022,
  author    = {Mertens, Alexander and Brauner, Philipp and Baier, Ralph and Brillowski, Florian and Dammers, Hannah and van Dyck, Marc and Kong, Iris and K{\"o}nigs, Peter and Kordtomeikel, Frauke and Liehner, Gian Luca and P{\"u}tz, Sebastian and Rodermann, Niklas and Schaar, Anne Kathrin and Steuer-Dankert, Linda and Vervier, Luisa and Wlecke, Shari and Gries, Thomas and Leicht-Scholten, Carmen and Nagel, Saskia K. and Piller, Frank T. and Schuh, G{\"u}nther and Ziefle, Martina and Nitsch, Verena},
  title     = {Modelling Human Factors in Cyber Physical Production Systems by the Integration of Human Digital Shadows},
  series = {Modellierung 2022 Satellite Events},
  booktitle = {Modellierung 2022 Satellite Events},
  editor    = {Michael, Judith and Pfeiffer, J{\´e}r{\^o}me and Wortmann, Andreas},
  publisher = {GI Gesellschaft f{\"u}r Informatik},
  address   = {Bonn},
  doi       = {10.18420/modellierung2022ws-018},
  pages     = {147 -- 149},
  year      = {2022},
  abstract  = {The future of industrial manufacturing and production will increasingly manifest in the form of cyber-physical production systems. Here, Digital Shadows will act as mediators between the physical and digital world to model and operationalize the interactions and relationships between different entities in production systems. Until now, the associated concepts have been primarily pursued and implemented from a technocentric perspective, in which human actors play a subordinate role, if they are considered at all. This paper outlines an anthropocentric approach that explicitly considers the characteristics, behavior, and traits and states of human actors in socio-technical production systems. For this purpose, we discuss the potentials and the expected challenges and threats of creating and using Human Digital Shadows in production.},
  language  = {en}
}
@masterthesis{Menrath2022,
  type      = {Bachelor Thesis},
  author    = {Menrath, Maike},
  title     = {Konzept zur Lebensmittelnahversorgung außerhalb urbaner Strukturen : Verkaufspunkt f{\"u}r l{\"a}ndliche Gebiete},
  publisher = {FH Aachen},
  address   = {Aachen},
  pages     = {131 Seiten},
  year      = {2022},
  abstract  = {L{\"a}ndliche Regionen sind h{\"a}ufig infrastrukturell schlechter versorgt als urbane R{\"a}ume, was sich insbesondere auf die Versorgung mit G{\"u}tern des t{\"a}glichen Bedarfs niederschl{\"a}gt. Menschen außerhalb st{\"a}dtischer Ballungsgebiete m{\"u}ssen deswegen oft lange Anfahrten zu Superm{\"a}rkten in Kauf nehmen. Hierbei sind sie vor allem auf das Auto angewiesen. In dieser Arbeit ist „ILSE" entstanden. Eine Verkaufsbox, die Menschen in l{\"a}ndlichen Raumstrukturen besser mit Waren versorgt, indem sie dort aufgestellt wird, wo sie auch wirklich ben{\"o}tigt wird. Dank digitaler Verkaufstechnologien ist „ILSE" durchgehend ge{\"o}ffnet, auch, wenn andere Superm{\"a}rkte l{\"a}ngst geschlossen sind. Mit einer App wird der Kundschaft der Zugang zum Verkaufsraum und das Bezahlen erm{\"o}glicht.},
  language  = {de}
}
@masterthesis{Meesters2022,
  type      = {Bachelor Thesis},
  author    = {Meesters, Elena},
  title     = {Gestaltung eines h{\"a}uslichen Telemonitoringsystems zur Prognose kardialer Dekompensation},
  publisher = {FH Aachen},
  address   = {Aachen},
  pages     = {113 Seiten},
  year      = {2022},
  abstract  = {Herzinsuffizienz ist eine der h{\"a}ufigsten Herzerkrankungen in Deutschland. Sie ist fortschreitend und nicht heilbar. Der Krankheitsverlauf ist gepr{\"a}gt von pl{\"o}tzlichen, z.T. lebensbedrohlichen Verschlechterungen und Krankenhauseinweisungen, nach denen die Leistung des Herzen vermindert bleibt. Diese Dekompensationen lassen sich bisher im heimischen Umfeld nicht durch Messwerte vorhersehen. Dieses Ger{\"a}t bestimmt die Fl{\"u}ssigkeitsansammlungen in der Lunge, die ein mittelfristiges Symptom einer Dekompensation sind. Außerdem misst es {\"u}ber einen Hautsensor die im Schweiß enthaltene Menge eines Proteins, das bei {\"U}berdehnung des Herzmuskels vermehrt im Blutplasma zu finden ist. So k{\"o}nnen Dekompensationen bis zu zwei Wochen vor einem akuten Ereignis detektiert und behandelt werden. Außerdem gibt es tagesformabh{\"a}ngige Tipps f{\"u}r die Alltagsgestaltung mit der Erkrankung.},
  language  = {de}
}