@article{KarschuckKaulenPoghossianetal.2021, author = {Karschuck, Tobias and Kaulen, Corinna and Poghossian, Arshak and Wagner, Patrick H. and Sch{\"o}ning, Michael Josef}, title = {Gold nanoparticle-modified capacitive field-effect sensors: Studying the surface density of nanoparticles and coupling of charged polyelectrolyte macromolecules}, series = {Electrochemical Science Advances}, volume = {2}, journal = {Electrochemical Science Advances}, number = {5}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {0938-5193}, doi = {10.1002/elsa.202100179}, pages = {10 Seiten}, year = {2021}, abstract = {The coupling of ligand-stabilized gold nanoparticles with field-effect devices offers new possibilities for label-free biosensing. In this work, we study the immobilization of aminooctanethiol-stabilized gold nanoparticles (AuAOTs) on the silicon dioxide surface of a capacitive field-effect sensor. The terminal amino group of the AuAOT is well suited for the functionalization with biomolecules. The attachment of the positively-charged AuAOTs on a capacitive field-effect sensor was detected by direct electrical readout using capacitance-voltage and constant capacitance measurements. With a higher particle density on the sensor surface, the measured signal change was correspondingly more pronounced. The results demonstrate the ability of capacitive field-effect sensors for the non-destructive quantitative validation of nanoparticle immobilization. In addition, the electrostatic binding of the polyanion polystyrene sulfonate to the AuAOT-modified sensor surface was studied as a model system for the label-free detection of charged macromolecules. Most likely, this approach can be transferred to the label-free detection of other charged molecules such as enzymes or antibodies.}, language = {en} } @misc{JungMuellerStaat2021, author = {Jung, Alexander and M{\"u}ller, Wolfram and Staat, Manfred}, title = {Corrigendum to "Wind and fairness in ski jumping: A computer modelling analysis" [J. Biomech. 75 (2018) 147-153]}, series = {Journal of Biomechanics}, volume = {128}, journal = {Journal of Biomechanics}, number = {Article number: 110690}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0021-9290}, doi = {10.1016/j.jbiomech.2021.110690}, pages = {1 Seite}, year = {2021}, language = {en} } @phdthesis{Jung2021, author = {Jung, Alexander}, title = {Electromechanical modelling and simulation of hiPSC-derived cardiac cell cultures}, publisher = {Universit{\"a}t Duisburg-Essen}, isbn = {978-3-9821811-1-0}, url = {http://nbn-resolving.de/https://nbn-resolving.org/urn:nbn:de:hbz:464-20210624-134942-7}, pages = {III, 135 Seiten}, year = {2021}, language = {en} } @incollection{JordanKatzPieper2021, author = {Jordan, Frank and Katz, Christiane and Pieper, Martin}, title = {Online-Kollaboration in der Mathematik: Ein Design-Based-Research-Projekt}, series = {Forschungsimpulse f{\"u}r hybrides Lehren und Lernen an Hochschulen}, booktitle = {Forschungsimpulse f{\"u}r hybrides Lehren und Lernen an Hochschulen}, publisher = {TH K{\"o}ln}, address = {K{\"o}ln}, url = {http://nbn-resolving.de/urn:nbn:de:hbz:832-cos4-9465}, pages = {245 -- 261}, year = {2021}, abstract = {Die Studie er{\"o}rtert anhand eines Fallbeispiels aus der Mathematik f{\"u}r Ingenieur*innen, wie didaktische Gestaltungsprinzipien f{\"u}r Soziale Pr{\"a}senz, Kollaboration und das L{\"o}sen von praxisnahen Problemen mit mathematischem Denken in einer Online-Umgebung aussehen k{\"o}nnen. Hierf{\"u}r zieht der Beitrag den forschungsmethodologischen Rahmen Design-Based Research (DBR) hinzu und berichtet {\"u}ber Zwischenergebnisse. DBR wird an dieser Stelle als eine systematische Herangehensweise an kurzfristige Lehrver{\"a}nderungen und als Chance auf dem Weg zu einer neuen Hochschullehre nach der COVID-19-Pandemie dargestellt, die theoretische und empirische Erkenntnisse mit Praxisverkn{\"u}pfung und -relevanz vereint.}, language = {de} } @masterthesis{Jonas2021, type = {Bachelor Thesis}, author = {Jonas, Eva Johanna}, title = {The future of work: How to create a better User Experience for distributed workforce}, publisher = {FH Aachen}, address = {Aachen}, school = {Fachhochschule Aachen}, pages = {213 Seiten}, year = {2021}, abstract = {Die Nachfrage nach flexiblen Arbeitsmodellen und damit Remote Work steigt und wird zunehmend zum Kriterium bei der Jobauswahl. Trotz der vielen Vorteile gibt es in der „Remote-Arbeitswelt" aber immer noch einige Herausforderungen. Remote Arbeitende haben eine andere, teils nachteilige Erfahrung gegen{\"u}ber Kollegen vor Ort. Um daf{\"u}r eine nutzerzentrierte L{\"o}sung zu finden, lag der Fokus bei dieser Arbeit auf den Auswirkungen und Bed{\"u}rfnissen des arbeitenden Menschen. Basierend hierauf wurde ein Dienstleistungsservice konzipiert. Dieser unterst{\"u}tzt Unternehmen, Selbstst{\"a}ndige und Mitarbeitende durch passende Angebote und Dienstleistungen in den Bereichen Ausstattung, Technik, Gesundheit, Corporate Benefits u.{\"A}. Dies erm{\"o}glicht auch Arbeitgebenden Aufgaben auszulagern und die Attraktivit{\"a}t und Konkurrenzf{\"a}higkeit auf dem Arbeitsmarkt zu steigern. Das wird zuk{\"u}nftig im „war for digitals talents" immer wichtiger werden.}, language = {de} } @article{JildehWagnerSchoening2021, author = {Jildeh, Zaid B. and Wagner, Patrick H. and Sch{\"o}ning, Michael Josef}, title = {Sterilization of Objects, Products, and Packaging Surfaces and Their Characterization in Different Fields of Industry: The Status in 2020}, series = {physica status solidi (a) applications and materials science}, volume = {218}, journal = {physica status solidi (a) applications and materials science}, number = {13}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.202000732}, pages = {27 Seiten}, year = {2021}, abstract = {The treatment method to deactivate viable microorganisms from objects or products is termed sterilization. There are multiple forms of sterilization, each intended to be applied for a specific target, which depends on—but not limited to—the thermal, physical, and chemical stability of that target. Herein, an overview on the currently used sterilization processes in the global market is provided. Different sterilization techniques are grouped under a category that describes the method of treatment: radiation (gamma, electron beam, X-ray, and ultraviolet), thermal (dry and moist heat), and chemical (ethylene oxide, ozone, chlorine dioxide, and hydrogen peroxide). For each sterilization process, the typical process parameters as defined by regulations and the mode of antimicrobial activity are summarized. Finally, the recommended microorganisms that are used as biological indicators to validate sterilization processes in accordance with the rules that are established by various regulatory agencies are summarized.}, language = {en} } @masterthesis{Jeiter2021, type = {Bachelor Thesis}, author = {Jeiter, Clara}, title = {AVES ­- die Evolution der V{\"o}gel : Design einer Naturkundeausstellung}, publisher = {FH Aachen}, address = {Aachen}, school = {Fachhochschule Aachen}, pages = {110 Seiten}, year = {2021}, abstract = {Der Tyrannosaurus-Rex ist der Uronkel des Haushuhns. Eine evolution{\"a}re Tatsache, die in Erstaunen versetzt. Vielen Menschen ist nicht bekannt, dass die heutigen V{\"o}gel von einem Zweig der fleischfressenden Dinosaurier, den Theropoden, abstammen. Die Bachelorarbeit mit dem Titel „AVES ­- Die Evolution der V{\"o}gel" zeigt die Entwicklung von der laufenden Echse hin zum fliegenden Vogel mittels einer Naturkundeausstellung. Dabei handelt es sich um eine Sonderausstellung, die sich f{\"u}r die Pr{\"a}sentation in musealen Institutionen eignet. Die chronologisch aufgebaute Ausstellung gliedert sich in sechs Zeitepochen, von der Urzeit bis hin zur Jetztzeit. Diese sind farblich und typografisch so gestaltet, dass sie den Besuchenden eine optimale Orientierung bieten. Hierbei f{\"u}gen sich einige gestalterische Elemente zusammen, wie plakative Tierillustrationen, die Themeninhalte untermalen, Waldkulissen und auditive Elemente, die eine Raumatmosph{\"a}re bilden. Die Ausstellung soll die Besuchenden durch die besondere Atmosph{\"a}re nicht nur emotional erreichen, sondern auch das inhaltliche Verst{\"a}ndnis f{\"o}rdern und festigen.}, language = {de} } @article{JablonskiPoghossianSeverinetal.2021, author = {Jablonski, Melanie and Poghossian, Arshak and Severin, Robin and Keusgen, Michael and Wege, Christian and Sch{\"o}ning, Michael Josef}, title = {Capacitive Field-Effect Biosensor Studying Adsorption of Tobacco Mosaic Virus Particles}, series = {Micromachines}, volume = {12}, journal = {Micromachines}, number = {1}, publisher = {MDPI}, address = {Basel}, doi = {10.3390/mi12010057}, pages = {Artikel 57}, year = {2021}, abstract = {Plant virus-like particles, and in particular, tobacco mosaic virus (TMV) particles, are increasingly being used in nano- and biotechnology as well as for biochemical sensing purposes as nanoscaffolds for the high-density immobilization of receptor molecules. The sensitive parameters of TMV-assisted biosensors depend, among others, on the density of adsorbed TMV particles on the sensor surface, which is affected by both the adsorption conditions and surface properties of the sensor. In this work, Ta₂O₅-gate field-effect capacitive sensors have been applied for the label-free electrical detection of TMV adsorption. The impact of the TMV concentration on both the sensor signal and the density of TMV particles adsorbed onto the Ta₂O₅-gate surface has been studied systematically by means of field-effect and scanning electron microscopy methods. In addition, the surface density of TMV particles loaded under different incubation times has been investigated. Finally, the field-effect sensor also demonstrates the label-free detection of penicillinase immobilization as model bioreceptor on TMV particles.}, language = {en} } @article{JablonskiPoghossianKeusgenetal.2021, author = {Jablonski, Melanie and Poghossian, Arshak and Keusgen, Michael and Wege, Christina and Sch{\"o}ning, Michael Josef}, title = {Detection of plant virus particles with a capacitive field-effect sensor}, series = {Analytical and Bioanalytical Chemistry}, volume = {413}, journal = {Analytical and Bioanalytical Chemistry}, publisher = {Springer Nature}, address = {Cham}, issn = {1618-2650}, doi = {10.1007/s00216-021-03448-8}, pages = {5669 -- 5678}, year = {2021}, abstract = {Plant viruses are major contributors to crop losses and induce high economic costs worldwide. For reliable, on-site and early detection of plant viral diseases, portable biosensors are of great interest. In this study, a field-effect SiO2-gate electrolyte-insulator-semiconductor (EIS) sensor was utilized for the label-free electrostatic detection of tobacco mosaic virus (TMV) particles as a model plant pathogen. The capacitive EIS sensor has been characterized regarding its TMV sensitivity by means of constant-capacitance method. The EIS sensor was able to detect biotinylated TMV particles from a solution with a TMV concentration as low as 0.025 nM. A good correlation between the registered EIS sensor signal and the density of adsorbed TMV particles assessed from scanning electron microscopy images of the SiO2-gate chip surface was observed. Additionally, the isoelectric point of the biotinylated TMV particles was determined via zeta potential measurements and the influence of ionic strength of the measurement solution on the TMV-modified EIS sensor signal has been studied.}, language = {en} } @article{JablonskiMuenstermannNorketal.2021, author = {Jablonski, Melanie and M{\"u}nstermann, Felix and Nork, Jasmina and Molinnus, Denise and Muschallik, Lukas and Bongaerts, Johannes and Wagner, Torsten and Keusgen, Michael and Siegert, Petra and Sch{\"o}ning, Michael Josef}, title = {Capacitive field-effect biosensor applied for the detection of acetoin in alcoholic beverages and fermentation broths}, series = {physica status solidi (a) applications and materials science}, volume = {218}, journal = {physica status solidi (a) applications and materials science}, number = {13}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.202000765}, pages = {7 Seiten}, year = {2021}, abstract = {An acetoin biosensor based on a capacitive electrolyte-insulator-semiconductor (EIS) structure modified with the enzyme acetoin reductase, also known as butane-2,3-diol dehydrogenase (Bacillus clausii DSM 8716ᵀ), is applied for acetoin detection in beer, red wine, and fermentation broth samples for the first time. The EIS sensor consists of an Al/p-Si/SiO₂/Ta₂O₅ layer structure with immobilized acetoin reductase on top of the Ta₂O₅ transducer layer by means of crosslinking via glutaraldehyde. The unmodified and enzyme-modified sensors are electrochemically characterized by means of leakage current, capacitance-voltage, and constant capacitance methods, respectively.}, language = {en} }