@article{WilsonDickieSchreiteretal.2018, author = {Wilson, C. E. and Dickie, A. P. and Schreiter, K. and Wehr, R. and Wilson, E. M. and Bial, J. and Scheer, Nico and Wilson, I. D. and Riley, R. J.}, title = {The pharmacokinetics and metabolism of diclofenac in chimeric humanized and murinized FRG mice}, series = {Archives of Toxicology}, volume = {92}, journal = {Archives of Toxicology}, number = {6}, publisher = {Springer}, issn = {1432-0738}, doi = {10.1007/s00204-018-2212-1}, pages = {1953 -- 1967}, year = {2018}, abstract = {The pharmacokinetics of diclofenac were investigated following single oral doses of 10 mg/kg to chimeric liver humanized and murinized FRG and C57BL/6 mice. In addition, the metabolism and excretion were investigated in chimeric liver humanized and murinized FRG mice. Diclofenac reached maximum blood concentrations of 2.43 ± 0.9 µg/mL (n = 3) at 0.25 h post-dose with an AUCinf of 3.67 µg h/mL and an effective half-life of 0.86 h (n = 2). In the murinized animals, maximum blood concentrations were determined as 3.86 ± 2.31 µg/mL at 0.25 h post-dose with an AUCinf of 4.94 ± 2.93 µg h/mL and a half-life of 0.52 ± 0.03 h (n = 3). In C57BL/6J mice, mean peak blood concentrations of 2.31 ± 0.53 µg/mL were seen 0.25 h post-dose with a mean AUCinf of 2.10 ± 0.49 µg h/mL and a half-life of 0.51 ± 0.49 h (n = 3). Analysis of blood indicated only trace quantities of drug-related material in chimeric humanized and murinized FRG mice. Metabolic profiling of urine, bile and faecal extracts revealed a complex pattern of metabolites for both humanized and murinized animals with, in addition to unchanged parent drug, a variety of hydroxylated and conjugated metabolites detected. The profiles in humanized mice were different to those of both murinized and wild-type animals, e.g., a higher proportion of the dose was detected in the form of acyl glucuronide metabolites and much reduced amounts as taurine conjugates. Comparison of the metabolic profiles obtained from the present study with previously published data from C57BL/6J mice and humans revealed a greater, though not complete, match between chimeric humanized mice and humans, such that the liver humanized FRG model may represent a model for assessing the biotransformation of such compounds in humans.}, language = {en} } @article{WilmingBegemannKuhneetal.2013, author = {Wilming, Anja and Begemann, Jens and Kuhne, Stefan and Regestein, Lars and Bongaerts, Johannes and Evers, Stefan and Maurer, Karl-Heinz and B{\"u}chs, Jochen}, title = {Metabolic studies of γ-polyglutamic acid production in Bacillus licheniformis by small-scale continuous cultivations}, series = {Biochemical engineering journal}, volume = {Vol. 73}, journal = {Biochemical engineering journal}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1873-295X (E-Journal); 1369-703X (Print)}, pages = {29 -- 37}, year = {2013}, language = {en} } @article{WillmsBeerFroehlkeetal.1993, author = {Willms, Herbert and Beer, Stefan and Fr{\"o}hlke, K. and Haidn, O.J. and [u.a.],}, title = {Regelung eines Wasserstoff-/Sauerstoff-Dampferzeugers mit Hilfe eines modifizierten Zirkondioxid-Sensors}, year = {1993}, language = {de} } @book{WillmsBeer1993, author = {Willms, Herbert and Beer, Stefan}, title = {Regelung eines H2/O2-Dampferzeugers}, publisher = {DLR, Zentrale Allgemeine Dienste, Versand}, address = {K{\"o}ln}, pages = {116 S. : graph. Darst.}, year = {1993}, language = {de} } @article{WillmsBeer1992, author = {Willms, Herbert and Beer, Stefan}, title = {Regelung eines H(IND 2)/O(IND 2)-Dampferzeugers}, isbn = {0939-2963}, year = {1992}, language = {de} } @book{Willms1987, author = {Willms, Herbert}, title = {Untersuchung der Wechselwirkung zwischen Str{\"o}mungsfeld und Reaktionsfront beim deflagrativen Abbrand von Kohlenwasserstoff-Luft-Gemischwolken}, publisher = {VDI-Verl.}, address = {D{\"u}sseldorf}, isbn = {3-18-142719-5}, pages = {VII, 168 S. : Ill., graph. Darst.}, year = {1987}, language = {de} } @article{Willms1993, author = {Willms, Herbert}, title = {Regelung eines H2/O2-Dampferzeugers mit Hilfe eines modifizierten Zirkondioxid-Sensors}, series = {Chemie Ingenieur Technik}, volume = {65}, journal = {Chemie Ingenieur Technik}, number = {8}, publisher = {Wiley-VCH}, address = {Weinheim}, isbn = {0009-286X}, pages = {954 -- 956}, year = {1993}, language = {de} } @masterthesis{Williams2023, type = {Bachelor Thesis}, author = {Williams, Vivian}, title = {Entwicklung eines neuen Erscheinungsbildes f{\"u}r Die Staatliche Antikensammlung in M{\"u}nchen}, publisher = {FH Aachen}, address = {Aachen}, pages = {111 Seiten}, year = {2023}, abstract = {Die Staatliche Antikensammlung in M{\"u}nchen ist eine antike Kunstsammlung, bestehend aus zwei Kunsth{\"a}usern. Das Haus der Glyptothek befindet sich auf der Nordseite und die Antikensammlung auf der S{\"u}dseite des K{\"o}nigsplatzes. W{\"a}hrend die Glyptothek Skulpturen ausstellt, zeigt die Antikensammlung Gebrauchsgegenst{\"a}nde und Objekte aus der etruskischen, griechischen und r{\"o}mischen Epoche. Sie geh{\"o}rt mit ihrer Kunstsammlung zu den weltweit f{\"u}hrenden ihrer Art. In seinem Vorhaben, das Kulturerbe zu wahren, legt das Museum besonders hohen Wert auf Bildung und Vermittlung. Um dies langfristig zu gew{\"a}hrleisten, ist ein ausgeglichenes Erscheinungsbild zwischen Klassik und Modernit{\"a}t unentbehrlich. Die griechische Stilepoche zeichnet sich in ihrer abstrakten Nutzung von geometrischen Grundformen aus. Im Zusammenspiel von geometrischen Formen und Abstrahierungen entsteht ein neues Erscheinungsbild.}, language = {de} } @book{Wilke2016, author = {Wilke, Thomas}, title = {Innendekoration : graphische Vorlagen und theoretische Vorgaben f{\"u}r die wandfeste Dekoration von Appartement im 17. und 18. Jahrhundert in Frankreich}, publisher = {scaneg Verlag}, address = {M{\"u}nchen}, isbn = {978-3-89235-233-4}, pages = {2 B{\"a}nde}, year = {2016}, language = {de} } @incollection{Wilke2015, author = {Wilke, Thomas}, title = {Weltkulturerbe(n). Die Residenzen des Hauses Savoyen in Turin und Umgebung}, series = {WeltkulturerbeN : Formen, Funktionen und Objekte kulturellen Erinnerns im und an das Mittelalter : Vortr{\"a}ge der Ringvorlesung des Zentrums f{\"u}r Mittelalterstudien der Otto-Friedrich-Universit{\"a}t Bamberg im Sommersemester 2013}, booktitle = {WeltkulturerbeN : Formen, Funktionen und Objekte kulturellen Erinnerns im und an das Mittelalter : Vortr{\"a}ge der Ringvorlesung des Zentrums f{\"u}r Mittelalterstudien der Otto-Friedrich-Universit{\"a}t Bamberg im Sommersemester 2013}, editor = {Schindler, Andrea}, publisher = {University of Bamberg Press}, address = {Bamberg}, isbn = {978-3-86309-385-3}, pages = {167 -- 196}, year = {2015}, language = {de} }