@article{GuoSekiMiyamotoetal.2014, author = {Guo, Yuanyuan and Seki, Kosuke and Miyamoto, Ko-ichiro and Wagner, Torsten and Sch{\"o}ning, Michael Josef and Yoshinobu, Tatsuo}, title = {Novel photoexcitation method for light-addressable potentiometric sensor with higher spatial resolution}, series = {Applied physics express : APEX}, volume = {7}, journal = {Applied physics express : APEX}, number = {6}, publisher = {IOP}, address = {Bristol}, issn = {1882-0786 (E-Journa); 1882-0778 (Print)}, doi = {10.7567/APEX.7.067301}, pages = {067301-4}, year = {2014}, abstract = {A novel photoexcitation method for the light-addressable potentiometric sensor (LAPS) is proposed to achieve a higher spatial resolution of chemical images. The proposed method employs a combined light source that consists of a modulated light probe, which generates the alternating photocurrent signal, and a ring of constant illumination surrounding it. The constant illumination generates a sheath of carriers with increased concentration which suppresses the spread of photocarriers by enhanced recombination. A device simulation was carried out to verify the effect of constant illumination on the spatial resolution, which demonstrated that a higher spatial resolution can be obtained.}, language = {en} } @article{GuoMiyamotoWagneretal.2014, author = {Guo, Yuanyuan and Miyamoto, Ko-ichiro and Wagner, Torsten and Sch{\"o}ning, Michael Josef and Yoshinobu, Tatsuo}, title = {Theoretical study and simulation of light-addressable potentiometric sensors}, series = {Physica status solidi (A) : applications and materials}, volume = {211}, journal = {Physica status solidi (A) : applications and materials}, number = {6}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {0031-8965}, doi = {10.1002/pssa.201330354}, pages = {1467 -- 1472}, year = {2014}, abstract = {The light-addressable potentiometric sensor (LAPS) is a semiconductor-based potentiometric sensor using a light probe with an ability of detecting the concentration of biochemical species in a spatially resolved manner. As an important biomedical sensor, research has been conducted to improve its performance, for instance, to realize high-speed measurement. In this work, the idea of facilitating the device-level simulation, instead of using an equivalent-circuit model, is presented for detailed analysis and optimization of the performance of the LAPS. Both carrier distribution and photocurrent response have been simulated to provide new insight into both amplitude-mode and phase-mode operations of the LAPS. Various device parameters can be examined to effectively design and optimize the LAPS structures and setups for enhanced performance.}, language = {en} } @article{GuoMiyamotoWagneretal.2014, author = {Guo, Yuanyuan and Miyamoto, Ko-ichiro and Wagner, Torsten and Sch{\"o}ning, Michael Josef and Yoshinobu, Tatsuo}, title = {Device simulation of the light-addressable potentiometric sensor for the investigation of the spatial resolution}, series = {Sensors and actuators B: Chemical}, volume = {204}, journal = {Sensors and actuators B: Chemical}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1873-3077 (E-Journal); 0925-4005 (Print)}, doi = {10.1016/j.snb.2014.08.016}, pages = {659 -- 665}, year = {2014}, abstract = {As a semiconductor-based electrochemical sensor, the light-addressable potentiometric sensor (LAPS) can realize two dimensional visualization of (bio-)chemical reactions at the sensor surface addressed by localized illumination. Thanks to this imaging capability, various applications in biochemical and biomedical fields are expected, for which the spatial resolution is critically significant. In this study, therefore, the spatial resolution of the LAPS was investigated in detail based on the device simulation. By calculating the spatiotemporal change of the distributions of electrons and holes inside the semiconductor layer in response to a modulated illumination, the photocurrent response as well as the spatial resolution was obtained as a function of various parameters such as the thickness of the Si substrate, the doping concentration, the wavelength and the intensity of illumination. The simulation results verified that both thinning the semiconductor substrate and increasing the doping concentration could improve the spatial resolution, which were in good agreement with known experimental results and theoretical analysis. More importantly, new findings of interests were also obtained. As for the dependence on the wavelength of illumination, it was found that the known dependence was not always the case. When the Si substrate was thick, a longer wavelength resulted in a higher spatial resolution which was known by experiments. When the Si substrate was thin, however, a longer wavelength of light resulted in a lower spatial resolution. This finding was explained as an effect of raised concentration of carriers, which reduced the thickness of the space charge region. The device simulation was found to be helpful to understand the relationship between the spatial resolution and device parameters, to understand the physics behind it, and to optimize the device structure and measurement conditions for realizing higher performance of chemical imaging systems.}, language = {en} } @article{GunSchoeningAbouzaretal.2008, author = {Gun, Jenny and Sch{\"o}ning, Michael Josef and Abouzar, Maryam H. and Poghossian, Arshak and Katz, Evgeny}, title = {Field-Effect Nanoparticle-Based Glucose Sensor on a Chip: Amplification Effect of Coimmobilized Redox Species}, series = {Electroanalysis. 20 (2008), H. 16}, journal = {Electroanalysis. 20 (2008), H. 16}, isbn = {1521-4109}, pages = {1748 -- 1753}, year = {2008}, language = {en} } @article{GunRizkovLevetal.2008, author = {Gun, Jenny and Rizkov, Dan and Lev, Ovadia and Abouzar, Maryam H. and Poghossian, Arshak and Sch{\"o}ning, Michael Josef}, title = {Oxygen plasma-treated gold nanoparticle-based field-effect devices as transducer structures for bio-chemical sensing}, series = {Microchimica Acta. 164 (2008), H. 3-4}, journal = {Microchimica Acta. 164 (2008), H. 3-4}, isbn = {1436-5073}, pages = {395 -- 404}, year = {2008}, language = {en} } @article{GunGutkinLevetal.2011, author = {Gun, Jenny and Gutkin, Vitaly and Lev, Ovadia and Boyen, Hans-Gerd and Saitner, Marc and Wagner, Patrick and Olieslaeger, Marc D´ and Abouzar, Maryam H. and Poghossian, Arshak and Sch{\"o}ning, Michael Josef}, title = {Tracing gold nanoparticle charge by electrolyte-insulator-semiconductor devices}, series = {Journal of Physical Chemistry C. 115 (2011), H. 11}, journal = {Journal of Physical Chemistry C. 115 (2011), H. 11}, publisher = {American Cemical Society}, address = {Washington, DC}, isbn = {1932-7455}, pages = {4439 -- 4445}, year = {2011}, language = {en} } @article{GrinsvenBonStrauvenetal.2012, author = {Grinsven, Bart van and Bon, Natalie vanden and Strauven, Hannelore and Grieten, Lars and Murib, Mohammed and Jim{\´e}nez Monroy, Kathia L. and Janssens, Stoffel D. and Haenen, Ken and Sch{\"o}ning, Michael Josef and Vermeeren, Veronique and Ameloot, Marcel and Michiels, Luc and Thoelen, Ronald and Ceuninck, Ward de and Wagner, Patrick}, title = {Heat-Transfer Resistance at Solid-Liquid Interfaces: A Tool for The Detection of Single Nucleotide Polymorphisms in DNA.}, series = {ACS Nano}, volume = {6}, journal = {ACS Nano}, number = {3}, publisher = {ACS Publications}, address = {Washington, DC}, issn = {1936-086X}, doi = {10.1021/nn300147e}, pages = {2712 -- 2721}, year = {2012}, abstract = {In this article, we report on the heat-transfer resistance at interfaces as a novel, denaturation-based method to detect single-nucleotide polymorphisms in DNA. We observed that a molecular brush of double-stranded DNA grafted onto synthetic diamond surfaces does not notably affect the heat-transfer resistance at the solid-to-liquid interface. In contrast to this, molecular brushes of single-stranded DNA cause, surprisingly, a substantially higher heat-transfer resistance and behave like a thermally insulating layer. This effect can be utilized to identify ds-DNA melting temperatures via the switching from low- to high heat-transfer resistance. The melting temperatures identified with this method for different DNA duplexes (29 base pairs without and with built-in mutations) correlate nicely with data calculated by modeling. The method is fast, label-free (without the need for fluorescent or radioactive markers), allows for repetitive measurements, and can also be extended toward array formats. Reference measurements by confocal fluorescence microscopy and impedance spectroscopy confirm that the switching of heat-transfer resistance upon denaturation is indeed related to the thermal on-chip denaturation of DNA.}, language = {en} } @article{GrinsvenBonGrietenetal.2011, author = {Grinsven, B. van and Bon, N. vanden and Grieten, L. and Murib, M. and Janssen, S. D. and Haenen, K. and Schneider, E. and Ingebrandt, E. and Sch{\"o}ning, Michael Josef and Vermeeren, V. and Ameloot, M. and Michiels, L. and Thoelen, R. and Ceuninck, W. de and Wagner, P.}, title = {Rapid assessment of the stability of DNA duplexes by impedimetric real-time monitoring of chemically induced denaturation}, series = {Lab on a Chip}, volume = {11}, journal = {Lab on a Chip}, number = {9}, publisher = {Royal Society of Chemistry (RSC)}, address = {Cambridge}, isbn = {1473-0197}, pages = {1656 -- 1663}, year = {2011}, language = {en} } @article{GivanoudiCornelisRasschaertetal.2021, author = {Givanoudi, Stella and Cornelis, Peter and Rasschaert, Geertrui and Wackers, Gideon and Iken, Heiko and Rolka, David and Yongabi, Derick and Robbens, Johan and Sch{\"o}ning, Michael Josef and Heyndrickx, Marc and Wagner, Patrick}, title = {Selective Campylobacter detection and quantification in poultry: A sensor tool for detecting the cause of a common zoonosis at its source}, series = {Sensors and Actuators B: Chemical}, journal = {Sensors and Actuators B: Chemical}, number = {In Press, Journal Pre-proof}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0925-4005}, doi = {10.1016/j.snb.2021.129484}, pages = {Article 129484}, year = {2021}, language = {en} } @article{GeMeyerSchoeningetal.2000, author = {Ge, B. and Meyer, T. and Sch{\"o}ning, Michael Josef and Wollenberger, U. and Lisdat, F.,}, title = {Cytochrome c' from Chromatium vinosum on gold electrodes}, series = {Electrochemistry Communications. 2 (2000), H. 8}, journal = {Electrochemistry Communications. 2 (2000), H. 8}, isbn = {1388-2481}, pages = {557 -- 561}, year = {2000}, language = {en} }