@techreport{DammAnthrakidisFend2016, author = {Damm, Marc Andr{\´e} and Anthrakidis, Anette and Fend, Thomas}, title = {Keramische Porenk{\"o}rpersysteme als SCR-Mischer und Hydrolysekatalysator : BMBF-Projekt: Hydromix : Schlussbericht : Laufzeit: 01.10.2011 bis 31.03.2015}, address = {Aachen}, pages = {30 Seiten : Illustrationen, Diagramme}, year = {2016}, language = {de} } @article{DallasSalphatiGomezZepedaetal.2016, author = {Dallas, Shannon and Salphati, Laurent and Gomez-Zepeda, David and Wanek, Thomas and Chen, Liangfu and Chu, Xiaoyan and Kunta, Jeevan and Mezler, Mario and Menet, Marie-Claude and Chasseigneaux, Stephanie and Decl{\`e}ves, Xavier and Langer, Oliver and Pierre, Esaie and DiLoreto, Karen and Hoft, Carolin and Laplanche, Loic and Pang, Jodie and Pereira, Tony and Andonian, Clara and Simic, Damir and Rode, Anja and Yabut, Jocelyn and Zhang, Xiaolin and Scheer, Nico}, title = {Generation and Characterization of a Breast Cancer Resistance Protein Humanized Mouse Model}, series = {Molecular Pharmacology}, volume = {89}, journal = {Molecular Pharmacology}, number = {5}, publisher = {ASPET}, address = {Bethesda, Md.}, issn = {1521-0111}, doi = {10.1124/mol.115.102079}, pages = {492 -- 504}, year = {2016}, abstract = {Breast cancer resistance protein (BCRP) is expressed in various tissues, such as the gut, liver, kidney and blood brain barrier (BBB), where it mediates the unidirectional transport of substrates to the apical/luminal side of polarized cells. Thereby BCRP acts as an efflux pump, mediating the elimination or restricting the entry of endogenous compounds or xenobiotics into tissues and it plays important roles in drug disposition, efficacy and safety. Bcrp knockout mice (Bcrp-/-) have been used widely to study the role of this transporter in limiting intestinal absorption and brain penetration of substrate compounds. Here we describe the first generation and characterization of a mouse line humanized for BCRP (hBCRP), in which the mouse coding sequence from the start to stop codon was replaced with the corresponding human genomic region, such that the human transporter is expressed under control of the murine Bcrp promoter. We demonstrate robust human and loss of mouse BCRP/Bcrp mRNA and protein expression in the hBCRP mice and the absence of major compensatory changes in the expression of other genes involved in drug metabolism and disposition. Pharmacokinetic and brain distribution studies with several BCRP probe substrates confirmed the functional activity of the human transporter in these mice. Furthermore, we provide practical examples for the use of hBCRP mice to study drug-drug interactions (DDIs). The hBCRP mouse is a promising model to study the in vivo role of human BCRP in limiting absorption and BBB penetration of substrate compounds and to investigate clinically relevant DDIs involving BCRP.}, language = {en} } @inproceedings{DalguerRenaultChurilovetal.2016, author = {Dalguer, Luis A. and Renault, Philippe and Churilov, Sergey and Butenweg, Christoph}, title = {Evaluation of fragility curves for a three-storey-reinforced-concrete mock-up of SMART 2013 project}, series = {Transactions, SMiRT-23 : 23rd Conference on Structural Mechanics in Reactor Technology : Manchester, United Kingdom - August 10-14, 2015}, booktitle = {Transactions, SMiRT-23 : 23rd Conference on Structural Mechanics in Reactor Technology : Manchester, United Kingdom - August 10-14, 2015}, organization = {Conference on Structural Mechanics in Reactor Technology <23, 2015, Manchester>}, pages = {1 -- 9}, year = {2016}, language = {en} } @inproceedings{Czarnecki2016, author = {Czarnecki, Christian}, title = {Design und Nutzung einer industriespezifischen Referenzarchitektur f{\"u}r die Telekommunikationsindustrie}, series = {GI Edition Proceedings Band 259 INFORMATIK 2016. 26.-30. September 2016 Klagenfurt}, booktitle = {GI Edition Proceedings Band 259 INFORMATIK 2016. 26.-30. September 2016 Klagenfurt}, editor = {Mayr, Heinrich C. and Pinzger, Martin and Gesellschaft f{\"u}r Informatik e. V. (GI),}, publisher = {K{\"o}llen}, address = {Bonn}, isbn = {9783885796534}, issn = {1617-5468}, pages = {807 -- 814}, year = {2016}, abstract = {Zur Unterst{\"u}tzung des Transformationsbedarfs von Telekommunikationsunternehmen sind die Referenzmodelle des TM Forums in der Praxis weltweit anerkannt. Dabei findet jedoch meist eine losgel{\"o}ste Nutzung f{\"u}r spezifische Einzelthemen statt. Daher f{\"u}hrt dieser Artikel die bestehenden Inhalte in einer industriespezifischen, {\"u}bergreifenden Referenzarchitektur zusammen. Der Fokus liegt auf den Ebenen Aufbauorganisation, Prozesse, Applikationen und Daten. Dar{\"u}ber hinaus werden inhaltliche Architekturdom{\"a}nen zur Strukturierung angeboten. Die Referenzarchitektur ist hierarchisch aufgebaut und wird hier beispielhaft f{\"u}r ausgew{\"a}hlte, aggregierte Inhalte beschrieben. Als erste Evaluation wird die Anwendung der Referenzarchitektur in drei Praxisprojekten erl{\"a}utert.}, language = {de} } @article{ChwallekFrohn2016, author = {Chwallek, Constanze and Frohn, Sandra}, title = {Den Mitarbeitern den R{\"u}cken st{\"a}rken}, series = {Personalwirtschaft}, journal = {Personalwirtschaft}, number = {5}, publisher = {F.A.Z. Business Media}, address = {Frankfurt a.M.}, issn = {0341-4698}, pages = {46 -- 48}, year = {2016}, abstract = {Ein Drittel der Mitarbeiter der Saint-Gobain Glass Deutschland GmbH hat drei Jahre lang regelm{\"a}ßig seinen R{\"u}cken trainiert. Mit Erfolg, wie eine abschließende Evaluation in Zusammenarbeit mit der FH Aachen zeigt. Die Fehltage der Trainingsteilnehmer sind enorm zur{\"u}ckgegangen, w{\"a}hrend die untrainierten Kollegen weiterhin unter R{\"u}ckenbeschwerden leiden.}, language = {de} } @article{ChenSchoembergKraffetal.2016, author = {Chen, Bixia and Schoemberg, Tobias and Kraff, Oliver and Dammann, Philipp and Bitz, Andreas and Schlamann, Marc and Quick, Harald H. and Ladd, Mark E. and Sure, Ulrich and Wrede, Karsten H.}, title = {Cranial fixation plates in cerebral magnetic resonance imaging: a 3 and 7 Tesla in vivo image quality study}, series = {Magnetic Resonance Materials in Physics, Biology and Medicine}, volume = {29}, journal = {Magnetic Resonance Materials in Physics, Biology and Medicine}, number = {3}, publisher = {Springer}, address = {Berlin}, issn = {1352-8661}, doi = {10.1007/s10334-016-0548-1}, pages = {389 -- 398}, year = {2016}, abstract = {Objective This study assesses and quantifies impairment of postoperative magnetic resonance imaging (MRI) at 7 Tesla (T) after implantation of titanium cranial fixation plates (CFPs) for neurosurgical bone flap fixation. Materials and methods The study group comprised five patients who were intra-individually examined with 3 and 7 T MRI preoperatively and postoperatively (within 72 h/3 months) after implantation of CFPs. Acquired sequences included T₁-weighted magnetization-prepared rapid-acquisition gradient-echo (MPRAGE), T₂-weighted turbo-spin-echo (TSE) imaging, and susceptibility-weighted imaging (SWI). Two experienced neurosurgeons and a neuroradiologist rated image quality and the presence of artifacts in consensus reading. Results Minor artifacts occurred around the CFPs in MPRAGE and T2 TSE at both field strengths, with no significant differences between 3 and 7 T. In SWI, artifacts were accentuated in the early postoperative scans at both field strengths due to intracranial air and hemorrhagic remnants. After resorption, the brain tissue directly adjacent to skull bone could still be assessed. Image quality after 3 months was equal to the preoperative examinations at 3 and 7 T. Conclusion Image quality after CFP implantation was not significantly impaired in 7 T MRI, and artifacts were comparable to those in 3 T MRI.}, language = {en} } @inproceedings{CapitainHeringTippkoetteretal.2016, author = {Capitain, C. and Hering, T. and Tippk{\"o}tter, Nils and Ulber, R.}, title = {Enzymatic polymerization of lignin model compounds and solubilized lignin in an aqueous ethanol extract}, series = {New frontiers of biotech-processes (Himmelfahrtstagung) : 02-04 May 2016, Rhein-Mosel-Halle, Koblenz/Germany}, booktitle = {New frontiers of biotech-processes (Himmelfahrtstagung) : 02-04 May 2016, Rhein-Mosel-Halle, Koblenz/Germany}, publisher = {DECHEMA}, address = {Frankfurt am Main}, pages = {151 -- 152}, year = {2016}, language = {en} } @inproceedings{BaeckerKochGeigeretal.2016, author = {B{\"a}cker, Matthias and Koch, C. and Geiger, F. and Eber, F. and Gliemann, H. and Poghossian, Arshak and Sch{\"o}ning, Michael Josef}, title = {A New Class of Biosensors Based on Tobacco Mosaic Virus and Coat Proteins as Enzyme Nanocarrier}, series = {Procedia Engineering}, volume = {Vol. 168}, booktitle = {Procedia Engineering}, issn = {1877-7058}, doi = {10.1016/j.proeng.2016.11.228}, pages = {618 -- 621}, year = {2016}, language = {en} } @incollection{ButenwegRoeser2016, author = {Butenweg, Christoph and Roeser, W.}, title = {Auslegung von Bauwerken gegen Erdbeben - Rechenbeispiele}, series = {Stahlbetonbau aktuell 2016 : Praxishandbuch / herausgegeben von: Prof. Dr.-Ing. Josef Hegger, Prof. Dr.-Ing. habil. Peter Mark}, booktitle = {Stahlbetonbau aktuell 2016 : Praxishandbuch / herausgegeben von: Prof. Dr.-Ing. Josef Hegger, Prof. Dr.-Ing. habil. Peter Mark}, publisher = {Beuth Verlag GmbH}, address = {Berlin ; Wien ; Z{\"u}rich}, isbn = {978-3-410-25202-3 (Print) ; 978-3-410-25203-0 (E-Book)}, year = {2016}, language = {de} } @article{ButenwegMarinkovicKubalskietal.2016, author = {Butenweg, Christoph and Marinkovic, Marko and Kubalski, Thomas and Klinkel, Sven}, title = {Masonry infilled reinforced concrete frames under horizontal loading}, series = {Mauerwerk}, volume = {20}, journal = {Mauerwerk}, number = {4}, publisher = {Ernst \& Sohn}, address = {Berlin}, issn = {1437-1022}, doi = {10.1002/dama.201600703}, pages = {305 -- 312}, year = {2016}, abstract = {The behaviour of infilled reinforced concrete frames under horizontal load has been widely investigated, both experimentally and numerically. Since experimental tests represent large investments, numerical simulations offer an efficient approach for a more comprehensive analysis. When RC frames with masonry infill walls are subjected to horizontal loading, their behaviour is highly non-linear after a certain limit, which makes their analysis quite difficult. The non-linear behaviour results from the complex inelastic material properties of the concrete, infill wall and conditions at the wall-frame interface. In order to investigate this non-linear behaviour in detail, a finite element model using a micro modelling approach is developed, which is able to predict the complex non-linear behaviour resulting from the different materials and their interaction. Concrete and bricks are represented by a non-linear material model, while each reinforcement bar is represented as an individual part installed in the concrete part and behaving elasto-plastically. Each brick is modelled individually and connected taking into account the non-linearity of a brick mortar interface. The same approach is followed using two finite element software packages and the results are compared with the experimental results. The numerical models show a good agreement with the experiments in predicting the overall behaviour, but also very good matching for strength capacity and drift. The results emphasize the quality and the valuable contribution of the numerical models for use in parametric studies, which are needed for the derivation of design recommendations for infilled frame structures.}, language = {en} }