@inproceedings{RauschLeiseEdereretal.2016,
  author    = {Rausch, Lea and Leise, Philipp and Ederer, Thorsten and Altherr, Lena and Pelz, Peter F.},
  title     = {A comparison of MILP and MINLP solver performance on the example of a drinking water supply system design problem},
  series = {ECCOMAS Congress 2016 VII European Congress on Computational Methods in Applied Sciences and Engineering},
  booktitle = {ECCOMAS Congress 2016 VII European Congress on Computational Methods in Applied Sciences and Engineering},
  editor    = {Papadrakakis, M. and Ppadopoulos, V. and Stefanou, G. and Plevris, V.},
  isbn      = {978-618-82844-0-1},
  pages     = {8509 -- 8527},
  year      = {2016},
  abstract  = {Finding a good system topology with more than a handful of components is a highly non-trivial task. The system needs to be able to fulfil all expected load cases, but at the same time the components should interact in an energy-efficient way. An example for a system design problem is the layout of the drinking water supply of a residential building. It may be reasonable to choose a design of spatially distributed pumps which are connected by pipes in at least two dimensions. This leads to a large variety of possible system topologies. To solve such problems in a reasonable time frame, the nonlinear technical characteristics must be modelled as simple as possible, while still achieving a sufficiently good representation of reality. The aim of this paper is to compare the speed and reliability of a selection of leading mathematical programming solvers on a set of varying model formulations. This gives us empirical evidence on what combinations of model formulations and solver packages are the means of choice with the current state of the art.},
  language  = {en}
}
@inproceedings{RajanHoltschoppenDalgueretal.2016,
  author    = {Rajan, Sreelakshmy and Holtschoppen, B. and Dalguer, L. A. and Klinkel, S. and Butenweg, Christoph},
  title     = {Seismic fragility analysis of a non-conventional reinforced concrete structure considering different uncertainties},
  series = {Proceedings of ISMA2016, International Conference on Noise and Vibration Engineering/USD2016, International Conference on Uncertainty in Structural Dynamics, / ISMA 2016, USD 2016},
  booktitle = {Proceedings of ISMA2016, International Conference on Noise and Vibration Engineering/USD2016, International Conference on Uncertainty in Structural Dynamics, / ISMA 2016, USD 2016},
  editor    = {Sas, P.},
  publisher = {KU Leuven},
  address   = {Leuven},
  pages     = {4213 -- 4225},
  year      = {2016},
  language  = {en}
}
@article{PookhalilAmoabedinyTabeshetal.2016,
  author    = {Pookhalil, Ali and Amoabediny, Ghassem and Tabesh, Hadi and Behbahani, Mehdi and Mottaghy, Khosrow},
  title     = {A new approach for semiempirical modeling of mechanical blood trauma},
  series = {The international journal of artificial organs},
  volume    = {39},
  journal   = {The international journal of artificial organs},
  number    = {4},
  publisher = {Sage},
  address   = {London},
  issn      = {1724-6040},
  doi       = {10.5301/ijao.5000474},
  pages     = {171 -- 177},
  year      = {2016},
  abstract  = {Purpose Two semi-empirical models were recently published, both making use of existing literature data, but each taking into account different physical phenomena that trigger hemolysis. In the first model, hemoglobin (Hb) release is described as a permeation procedure across the membrane, assuming a shear stress-dependent process (sublethal model). The second model only accounts for hemoglobin release that is caused by cell membrane breakdown, which occurs when red blood cells (RBC) undergo mechanically induced shearing for a period longer than the threshold time (nonuniform threshold model). In this paper, we introduce a model that considers the hemolysis generated by both these possible phenomena. Methods Since hemolysis can possibly be caused by permeation of hemoglobin through the RBC functional membrane as well as by release of hemoglobin from RBC membrane breakdown, our proposed model combines both these models. An experimental setup consisting of a Couette device was utilized for validation of our proposed model. Results A comparison is presented between the damage index (DI) predicted by the proposed model vs. the sublethal model vs. the nonthreshold model and experimental datasets. This comparison covers a wide range of shear stress for both human and porcine blood. An appropriate agreement between the measured DI and the DI predicted by the present model was obtained. Conclusions The semiempirical hemolysis model introduced in this paper aims for significantly enhanced conformity with experimental data. Two phenomenological outcomes become possible with the proposed approach: an estimation of the average time after which cell membrane breakdown occurs under the applied conditions, and a prediction of the ratio between the phenomena involved in hemolysis.},
  language  = {en}
}
@inproceedings{PoghossianBronderSchejaetal.2016,
  author    = {Poghossian, Arshak and Bronder, Thomas and Scheja, S. and Wu, Chunsheng and Metzger-Boddien, C. and Keusgen, M. and Sch{\"o}ning, Michael Josef},
  title     = {Label-free Electrostatic Detection of DNA Amplification by PCR Using Capacitive Field-effect Devices},
  series = {Procedia Engineering},
  volume    = {Vol. 168},
  booktitle = {Procedia Engineering},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1877-7058},
  doi       = {10.1016/j.proeng.2016.11.512},
  pages     = {514 -- 517},
  year      = {2016},
  abstract  = {A capacitive field-effect EIS (electrolyte-insulator-semiconductor) sensor modified with a positively charged weak polyelectrolyte of poly(allylamine hydrochloride) (PAH)/single-stranded probe DNA (ssDNA) bilayer has been used for a label-free electrostatic detection of pathogen-specific DNA amplification via polymerase chain reaction (PCR). The sensor is able to distinguish between positive and negative PCR solutions, to detect the existence of target DNA amplicons in PCR samples and thus, can be used as tool for a quick verification of DNA amplification and the successful PCR process.},
  language  = {en}
}
@article{PinkenburgSchiffelsSelmer2016,
  author    = {Pinkenburg, Olaf and Schiffels, Johannes and Selmer, Thorsten},
  title     = {Das CoLibry-Konzept - ein Werkzeugkasten f{\"u}r die Synthetische Biologie: Bioproduktion},
  series = {BIOspektrum},
  volume    = {22},
  journal   = {BIOspektrum},
  number    = {6},
  publisher = {Springer},
  address   = {Berlin},
  doi       = {10.1007/s12268-016-0734-8},
  pages     = {593 -- 595},
  year      = {2016},
  abstract  = {Regardless of size or destination, synthetic biology starts with com-parably small information units, which need to be combined and properly arranged in order to achieve a certain goal. This may be the de novo synthesis of individual genes from oligonucleotides, a shuffling of protein domains in order to create novel biocatalysts, the assembly of multiple enzyme encoding genes in metabolic pathway design, or strain development at the production stage. The CoLibry concept has been designed in order to close the gap between recombinant production of individual genes and genome editing.},
  language  = {de}
}
@article{PfaffSchmidt2016,
  author    = {Pfaff, Raphael and Schmidt, Bernd},
  title     = {Daten in der Cloud - und dann?},
  series = {Deine Bahn},
  journal   = {Deine Bahn},
  number    = {6},
  publisher = {Bahn-Fachverlag},
  address   = {Berlin},
  issn      = {0948-7263},
  pages     = {50 -- 55},
  year      = {2016},
  abstract  = {Schienenverkehrssysteme stehen in zunehmendem Wettbewerb, sowohl untereinander als auch mit anderen Verkehrstr{\"a}gern. Als wichtiger Aspekt zur Steigerung der Kosteneffizienz wird die Digitalisierung des Betriebs und der Fahrzeuge betrachtet. {\"U}ber eine Prognose der Ausfallwahrscheinlichkeit bzw. Restlebensdauer von Subsystemen k{\"o}nnen mittels Digitalisierung die Instandhaltungskosten gesenkt werden. Die geringen Fehlerraten im System Bahn machen die Nutzung besonderer Simulationstechniken notwendig. In diesem Beitrag wird gezeigt, wie sich die Subsystemverf{\"u}gbarkeit aus den beobachteten Fehlerraten der Teilfunktionen vorhersagen l{\"a}sst.},
  language  = {de}
}
@article{PeloniCeriottiDachwald2016,
  author    = {Peloni, Alessandro and Ceriotti, Matteo and Dachwald, Bernd},
  title     = {Solar-sail trajectory design for a multiple near-earth-asteroid rendezvous mission},
  series = {Journal of Guidance, Control, and Dynamics},
  volume    = {39},
  journal   = {Journal of Guidance, Control, and Dynamics},
  number    = {12},
  publisher = {AIAA},
  address   = {Reston, Va.},
  issn      = {0731-5090},
  doi       = {10.2514/1.G000470},
  pages     = {2712 -- 2724},
  year      = {2016},
  abstract  = {The scientific interest for near-Earth asteroids as well as the interest in potentially hazardous asteroids from the perspective of planetary defense led the space community to focus on near-Earth asteroid mission studies. A multiple near-Earth asteroid rendezvous mission with close-up observations of several objects can help to improve the characterization of these asteroids. This work explores the design of a solar-sail spacecraft for such a mission, focusing on the search of possible sequences of encounters and the trajectory optimization. This is done in two sequential steps: a sequence search by means of a simplified trajectory model and a set of heuristic rules based on astrodynamics, and a subsequent optimization phase. A shape-based approach for solar sailing has been developed and is used for the first phase. The effectiveness of the proposed approach is demonstrated through a fully optimized multiple near-Earth asteroid rendezvous mission. The results show that it is possible to visit five near-Earth asteroids within 10 years with near-term solar-sail technology.},
  language  = {en}
}
@article{PaulssenLengkeekLeetal.2016,
  author    = {Paulßen, Elisabeth and Lengkeek, Nigel A. and Le, Van So and Pellegrini, Paul A. and Greguric, Ivan and Weiner, Ron},
  title     = {The role of additives in moderating the influence of Fe(III) and Cu(II) on the radiochemical yield of [⁶⁸Ga(DOTATATE)]},
  series = {Applied Radiation and Isotopes},
  volume    = {107},
  journal   = {Applied Radiation and Isotopes},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1872-9800},
  doi       = {10.1016/j.apradiso.2015.09.008},
  pages     = {13 -- 16},
  year      = {2016},
  abstract  = {[⁶⁸Ga(DOTATATE)] has demonstrated its clinical usefulness. Both Fe³⁺ and Cu²⁺, potential contaminants in Gallium-68 generator eluent, substantially reduce the radiochemical (RC) yield of [⁶⁸Ga(DOTATATE)] if the metal/ligand ratio of 1:1 is exceeded. A variety of compounds were examined for their potential ability to reduce this effect. Most had no effect on RC yield. However, addition of phosphate diminished the influence of Fe³⁺ by likely forming an insoluble iron salt. Addition of ascorbic acid reduced Cu²⁺ and Fe³⁺ to Cu⁺ and Fe²⁺ respectively, both of which have limited impact on RC yields. At low ligand amounts (5 nmol DOTATATE), the addition of 30 nmol phosphate (0.19 mM) increased the tolerance of Fe3⁺ from 4 nmol to 10 nmol (0.06 mM), while the addition of ascorbic acid allowed high RC yields (>95\%) in the presence of 40 nmol Fe³⁺ (0.25 mM) and 100 nmol Cu²⁺ (0.63 mM). The effect of ascorbic acid was highly pH-dependant, and gave optimal results at pH 3.},
  language  = {en}
}
@inproceedings{OttenSchmidtWeber2016,
  author    = {Otten, D. and Schmidt, M. and Weber, Tobias},
  title     = {Advances in Determination of Material Parameters for Functional Simulations Based on Process Simulations},
  series = {SAMPE Europe Conference 16 Liege},
  booktitle = {SAMPE Europe Conference 16 Liege},
  isbn      = {978-1-5108-3800-0},
  pages     = {570 -- 577},
  year      = {2016},
  language  = {en}
}
@article{OrzadaLaddBitz2016,
  author    = {Orzada, Stephan and Ladd, Mark E. and Bitz, Andreas},
  title     = {A method to approximate maximum local SAR in multichannel transmit MR systems without transmit phase information},
  series = {Magnetic Resonance in Medicine},
  volume    = {78},
  journal   = {Magnetic Resonance in Medicine},
  number    = {2},
  publisher = {International Society for Magnetic Resonance in Medicine},
  issn      = {1522-2594},
  doi       = {10.1002/mrm.26398},
  pages     = {805 -- 811},
  year      = {2016},
  abstract  = {Purpose To calculate local specific absorption rate (SAR) correctly, both the amplitude and phase of the signal in each transmit channel have to be known. In this work, we propose a method to derive a conservative upper bound for the local SAR, with a reasonable safety margin without knowledge of the transmit phases of the channels. Methods The proposed method uses virtual observation points (VOPs). Correction factors are calculated for each set of VOPs that prevent underestimation of local SAR when the VOPs are applied with the correct amplitudes but fixed phases. Results The proposed method proved to be superior to the worst-case calculation based on the maximum eigenvalue of the VOPs. The mean overestimation for six coil setups could be reduced, whereas no underestimation of the maximum local SAR occurred. In the best investigated case, the overestimation could be reduced from a factor of 3.3 to a factor of 1.7. Conclusion The upper bound for the local SAR calculated with the proposed method allows a fast estimation of the local SAR based on power measurements in the transmit channels and facilitates SAR monitoring in systems that do not have the capability to monitor transmit phases},
  language  = {en}
}