@techreport{OPUS4-342, title = {Forschungsbericht der FH Aachen 2012}, organization = {FH Aachen, University of Applied Sciences}, year = {2012}, abstract = {Forschungsbericht / Themenheft : Querschnittsthemen 4 Grußwort Prorektorin Prof. Dr. rer. nat. Christiane Vaeßen 6 Highlightprojekte 8 Erfolgsmeldungen aus der Wissenschaft 10 Konstruktion, Planung und Gestaltung / Institut f{\"u}r Baustoffe und Baukonstruktionen (IBB) 12 Stahlbaulabor 13 Geografische Informationssysteme in der Gew{\"a}sserplanung 14 Didaktisch visuelle Einf{\"u}hrung in die Architektur des Aachener Doms 16 CIVITAS-DYN@MO 17 Laserinstallation „fluently scientific" 18 Subversive Sch{\"o}nheit 19 Gestaltung als Tool Wirtschaftswissenschaften 24 Cross-cultural Training 26 Unternehmerische Orientierung in etablierten Unternehmen - der Einfluss des Top-Management-F{\"u}hrungsstils im internationalen Vergleich 28 LEAN LAB 30 QFD - Stand der Anwendung und Perspektiven in Deutschland 34 Entwicklung eines universellen Qualit{\"a}tskontrollzentrums 35 Telekommunikationsm{\"a}rkte der Zukunft MINT 38 Forschungsprojekt GPUFaserVis - Visualisierung von hochaufl{\"o}senden Nervenfasern des Gehirns 39 "3rd pulse plasma bulb" (quasi-quecksilberfreie HF-Energiesparlampe) 40 Labor f{\"u}r Nuklearchemie 44 CHERNE - Die Erfolgsgeschichte eines Hochschulnetzwerks 46 Steigerung der Immunogenit{\"a}t von therapeutischen Impfstoffen gegen Krebs (INB) 47 Direkter Nachweis von geladenen Makromolek{\"u}len mit Feldeffekt-Biosensoren, "veredelt" mit Keramikoberfl{\"a}chen (INB) 48 Smartphones - kleine Allesk{\"o}nner, die viel {\"u}ber uns wissen 49 Gebrauchstaugliche IT-Systeme f{\"u}r den Mittelstand 51 Engineering-Useability mit Motion-Controllern 52 Labor f{\"u}r Elektrische Antriebssysteme : Rapid-Control-Protoyping von Industrieantrieben 53 Einzelteilfertigung komplexer Endprodukte am Beispiel Zahntechnik und Goldschmiedekunst 55 Schadstoffarme Wasserstoff und Syngas-Verbrennung f{\"u}r die Energieversorgung von morgen 56 EC2GO - Thermomanagement im E-Carsharing 57 SORT Standardised On-Road Test Cycles 58 EIC - Exhaust Impulse Charger 59 Der Blitz - Doch nicht unberechenbar! Ein dynamisches Modell zur Berechnung von Einschlagstellen und Einschlagwahrscheinlichkeiten 60 ETL QUADRAT: Semantische Annotationen in ETL-Prozessen als Qualit{\"a}ts- und Effizienztreiber f{\"u}r Datenaggregatoren im Internet 61 HiX4AGWS: History-tracing XML for an Actor-driven Grid-enabled Workflow System 62 Impressum}, subject = {Forschungsbericht}, language = {de} } @article{GrandeMeffertSchoenbergeretal.2012, author = {Grande, Marion and Meffert, Elisabeth and Schoenberger, Eva and Jung, Stefanie and Frauenrath, Tobias and Huber, Walter and Hussmann, Katja and Moormann, Mareike and Heim, Stefan}, title = {From a concept to a word in a syntactically complete sentence: An fMRI study on spontaneous language production in an overt picture description task}, series = {NeuroImage}, volume = {61}, journal = {NeuroImage}, number = {3}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1522-2586}, doi = {10.1016/j.neuroimage.2012.03.087}, pages = {702 -- 714}, year = {2012}, abstract = {Spontaneous language has rarely been subjected to neuroimaging studies. This study therefore introduces a newly developed method for the analysis of linguistic phenomena observed in continuous language production during fMRI. Most neuroimaging studies investigating language have so far focussed on single word or — to a smaller extent — sentence processing, mostly due to methodological considerations. Natural language production, however, is far more than the mere combination of words to larger units. Therefore, the present study aimed at relating brain activation to linguistic phenomena like word-finding difficulties or syntactic completeness in a continuous language fMRI paradigm. A picture description task with special constraints was used to provoke hesitation phenomena and speech errors. The transcribed speech sample was segmented into events of one second and each event was assigned to one category of a complex schema especially developed for this purpose. The main results were: conceptual planning engages bilateral activation of the precuneus. Successful lexical retrieval is accompanied - particularly in comparison to unsolved word-finding difficulties - by the left middle and superior temporal gyrus. Syntactic completeness is reflected in activation of the left inferior frontal gyrus (IFG) (area 44). In sum, the method has proven to be useful for investigating the neural correlates of lexical and syntactic phenomena in an overt picture description task. This opens up new prospects for the analysis of spontaneous language production during fMRI.}, language = {en} } @book{Doeren2012, author = {D{\"o}ren, Horst-Peter}, title = {F{\"u}getechnik, Schweißtechnik. Horst-Peter D{\"o}ren (Hrsg.).- 8., aktualis. und erw. Aufl.}, publisher = {DVS Media}, address = {D{\"u}sseldorf}, isbn = {978-3-87155-999-0}, pages = {411 S.: Ill., graph. Darst.}, year = {2012}, language = {de} } @incollection{Fabo2012, author = {Fabo, Sabine}, title = {Gef{\"a}hrliche Liebschaften : Kunst zwischen Wderstand und Umarmung}, series = {Interventionen : Grenz{\"u}berschreitungen in {\"A}sthetik, Politik und {\"O}konomie}, booktitle = {Interventionen : Grenz{\"u}berschreitungen in {\"A}sthetik, Politik und {\"O}konomie}, editor = {Hartmann, Doreen and [u.a.],}, publisher = {Fink}, address = {M{\"u}nchen [u.a.]}, isbn = {978-3-7705-5283-2}, pages = {173 -- 189}, year = {2012}, language = {de} } @incollection{Fabo2012, author = {Fabo, Sabine}, title = {Gef{\"a}hrliche Liebschaften : Kunst zwischen Widerstand und Umarmung}, series = {Interventionen : Grenz{\"u}berschreitungen in {\"A}sthetik, Politik und {\"O}konomie}, booktitle = {Interventionen : Grenz{\"u}berschreitungen in {\"A}sthetik, Politik und {\"O}konomie}, editor = {Hartmann, Doreen}, publisher = {Fink}, address = {M{\"u}nchen}, isbn = {978-3-7705-5283-2}, pages = {173 -- 189}, year = {2012}, language = {de} } @article{BeckerDelfmannEggertetal.2012, author = {Becker, J{\"o}rg and Delfmann, Patrick and Eggert, Mathias and Schwittay, Sebastian}, title = {Generalizability and Applicability of Model-Based Business Process Compliance-Checking Approaches — A State-of-the-Art Analysis and Research Roadmap}, series = {Business Research : BuR}, volume = {5}, journal = {Business Research : BuR}, number = {2}, publisher = {Springer}, address = {Heidelberg}, issn = {1866-8658}, doi = {10.1007/BF03342739}, pages = {221 -- 247}, year = {2012}, abstract = {With a steady increase of regulatory requirements for business processes, automation support of compliance management is a field garnering increasing attention in Information Systems research. Several approaches have been developed to support compliance checking of process models. One major challenge for such approaches is their ability to handle different modeling techniques and compliance rules in order to enable widespread adoption and application. Applying a structured literature search strategy, we reflect and discuss compliance-checking approaches in order to provide an insight into their generalizability and evaluation. The results imply that current approaches mainly focus on special modeling techniques and/or a restricted set of types of compliance rules. Most approaches abstain from real-world evaluation which raises the question of their practical applicability. Referring to the search results, we propose a roadmap for further research in model-based business process compliance checking.}, language = {en} } @article{ScheerBalimaneHaywardetal.2012, author = {Scheer, Nico and Balimane, Praveen and Hayward, Michael D. and Buechel, Sandra and Kauselmann, Gunther and Wolf, C. Roland}, title = {Generation and Characterization of a Novel Multidrug Resistance Protein 2 Humanized Mouse Line}, series = {Drug Metabolism and Disposition}, volume = {40}, journal = {Drug Metabolism and Disposition}, number = {11}, publisher = {ASPET}, address = {Bethesda, Md.}, issn = {1521-0111}, doi = {10.1124/dmd.112.047605}, pages = {2212 -- 2218}, year = {2012}, abstract = {The multidrug resistance protein (MRP) 2 is predominantly expressed in liver, intestine, and kidney, where it plays an important role in the excretion of a range of drugs and their metabolites or endogenous compounds into bile, feces, and urine. Mrp knockout [Mrp2(-/-)] mice have been used recently to study the role of MRP2 in drug disposition. Here, we describe the first generation and initial characterization of a mouse line humanized for MRP2 (huMRP2), which is nulled for the mouse Mrp2 gene and expresses the human transporter in the organs and cell types where MRP2 is normally expressed. Analysis of the mRNA expression for selected cytochrome P450 and transporter genes revealed no major changes in huMRP2 mice compared with wild-type controls. We show that human MRP2 is able to compensate functionally for the loss of the mouse transporter as demonstrated by comparable bilirubin levels in the humanized mice and wild-type controls, in contrast to the hyperbilirubinemia phenotype that is observed in MRP2(-/-) mice. The huMRP2 mouse provides a model to study the role of the human transporter in drug disposition and in assessing the in vivo consequences of inhibiting this transporter by compounds interacting with human MRP2.}, language = {en} } @article{ScheerKapelyukhRodeetal.2012, author = {Scheer, Nico and Kapelyukh, Yury and Rode, Anja and Buechel, Sandra and Wolf, C. Roland}, title = {Generation and characterization of novel cytochrome P450 Cyp2c gene cluster knockout and CYP2C9 humanized mouse lines}, series = {Molecular Pharmacology}, volume = {82}, journal = {Molecular Pharmacology}, number = {6}, publisher = {ASPET}, address = {Bethesda, Md.}, issn = {1521-0111}, doi = {10.1124/mol.112.080036}, pages = {1022 -- 1029}, year = {2012}, abstract = {Compared with rodents and many other animal species, the human cytochrome P450 (P450) Cyp2c gene cluster varies significantly in the multiplicity of functional genes and in the substrate specificity of its enzymes. As a consequence, the use of wild-type animal models to predict the role of human CYP2C enzymes in drug metabolism and drug-drug interactions is limited. Within the human CYP2C cluster CYP2C9 is of particular importance, because it is one of the most abundant P450 enzymes in human liver, and it is involved in the metabolism of a wide variety of important drugs and environmental chemicals. To investigate the in vivo functions of cytochrome P450 Cyp2c genes and to establish a model for studying the functions of CYP2C9 in vivo, we have generated a mouse model with a deletion of the murine Cyp2c gene cluster and a corresponding humanized model expressing CYP2C9 specifically in the liver. Despite the high number of functional genes in the mouse Cyp2c cluster and the reported roles of some of these proteins in different biological processes, mice deleted for Cyp2c genes were viable and fertile but showed certain phenotypic alterations in the liver. The expression of CYP2C9 in the liver also resulted in viable animals active in the metabolism and disposition of a number of CYP2C9 substrates. These mouse lines provide a powerful tool for studying the role of Cyp2c genes and of CYP2C9 in particular in drug disposition and as a factor in drug-drug interaction.}, language = {en} } @article{BorgmeierBongaertsMeinhardt2012, author = {Borgmeier, Claudia and Bongaerts, Johannes and Meinhardt, Friedhelm}, title = {Genetic analysis of the Bacillus licheniformis degSU operon and the impact of regulatory mutations on protease production}, series = {Journal of biotechnology}, volume = {159}, journal = {Journal of biotechnology}, number = {1-2}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1873-4863 (E-Journal); 0168-1656 (Print)}, doi = {10.1016/j.jbiotec.2012.02.011}, pages = {12 -- 20}, year = {2012}, abstract = {Disruption experiments targeted at the Bacillus licheniformis degSU operon and GFP-reporter analysis provided evidence for promoter activity immediately upstream of degU. pMutin mediated concomitant introduction of the degU32 allele - known to cause hypersecretion in Bacillus subtilis - resulted in a marked increase in protease activity. Application of 5-fluorouracil based counterselection through establishment of a phosphoribosyltransferase deficient Δupp strain eventually facilitated the marker-free introduction of degU32 leading to further protease enhancement achieving levels as for hypersecreting wild strains in which degU was overexpressed. Surprisingly, deletion of rapG - known to interfere with DegU DNA-binding in B. subtilis - did not enhance protease production neither in the wild type nor in the degU32 strain. The combination of degU32 and Δupp counterselection in the type strain is not only equally effective as in hypersecreting wild strains with respect to protease production but furthermore facilitates genetic strain improvement aiming at biological containment and effectiveness of biotechnological processes.}, language = {en} } @incollection{Feiser2012, author = {Feiser, Johannes}, title = {Geotechnik}, series = {Wendehorst Bautechnische Zahlentafeln}, booktitle = {Wendehorst Bautechnische Zahlentafeln}, editor = {Vismann, Ulrich}, edition = {34}, publisher = {Vieweg + Teubner}, address = {Wiesbaden}, isbn = {978-3-8348-0960-5}, doi = {10.1007/978-3-8348-8613-2_17}, pages = {1221 -- 1332}, year = {2012}, abstract = {In der nationalen und der europ{\"a}ischen Normung werden die geotechnischen Aufgaben zwecks Mindestanforderungen an Baugrunduntersuchung, rechnerische Nachweise und {\"U}berwachung der Ausf{\"u}hrung in drei Klassen (Kategorien) eingeteilt. Sie richten sich nach der zu erwartenden Reaktion des Baugrundes, nach dem geotechnischen Schwierigkeitsgrad des Tragwerks und seiner Einfl{\"u}sse auf dieUmgebung.}, language = {de} }