@article{ScheerKapelyukhMcEwanetal.2012,
  author    = {Scheer, Nico and Kapelyukh, Yury and McEwan, Jillian and Beuger, Vincent and Stanley, Lesley A. and Rode, Anja and Wolf, C. Roland},
  title     = {Modeling Human Cytochrome P450 2D6 Metabolism and Drug-drug Interaction by a Novel Panel of Knockout and Humanized Mouse Lines},
  series = {Molecular Pharmacology},
  volume    = {81},
  journal   = {Molecular Pharmacology},
  number    = {1},
  publisher = {ASPET},
  address   = {Bethesda, Md.},
  issn      = {1521-0111},
  doi       = {10.1124/mol.111.075192},
  pages     = {63 -- 72},
  year      = {2012},
  abstract  = {The highly polymorphic human cytochrome P450 2D6 enzyme is involved in the metabolism of up to 25\% of all marketed drugs and accounts for significant individual differences in response to CYP2D6 substrates. Because of the differences in the multiplicity and substrate specificity of CYP2D family members among species, it is difficult to predict pathways of human CYP2D6-dependent drug metabolism on the basis of animal studies. To create animal models that reflect the human situation more closely and that allow an in vivo assessment of the consequences of differential CYP2D6 drug metabolism, we have developed a novel straightforward approach to delete the entire murine Cyp2d gene cluster and replace it with allelic variants of human CYP2D6. By using this approach, we have generated mouse lines expressing the two frequent human protein isoforms CYP2D6.1 and CYP2D6.2 and an as yet undescribed variant of this enzyme, as well as a Cyp2d cluster knockout mouse. We demonstrate that the various transgenic mouse lines cover a wide spectrum of different human CYP2D6 metabolizer phenotypes. The novel humanization strategy described here provides a robust approach for the expression of different CYP2D6 allelic variants in transgenic mice and thus can help to evaluate potential CYP2D6-dependent interindividual differences in drug response in the context of personalized medicine.},
  language  = {en}
}
@article{ReisgenSchleserMokrovetal.2012,
  author    = {Reisgen, Uwe and Schleser, Markus and Mokrov, Oleg and Zabirov, Alexander and F{\"u}ssel, Uwe and Schnick, Michael and Hertel, Martin and Jaeckel, Sebastian},
  title     = {Modellierung und Visualisierung der MSG-Lichtbogenprozesse},
  series = {Schweissen und Schneiden : Fachzeitschrift f{\"u}r Schweißen und verwandte Verfahren},
  volume    = {64},
  journal   = {Schweissen und Schneiden : Fachzeitschrift f{\"u}r Schweißen und verwandte Verfahren},
  number    = {4},
  publisher = {DVS Verlag},
  address   = {D{\"u}sseldorf},
  issn      = {0036-7184},
  pages     = {166 -- 174},
  year      = {2012},
  language  = {de}
}
@inproceedings{AlexopoulosRauHoffschmidtetal.2012,
  author    = {Alexopoulos, Spiros and Rau, Christoph and Hoffschmidt, Bernhard and Breitbach, Gerd and Latzke, Markus},
  title     = {Modelling and validation of a transient heat recovery steam generator of the solar tower power plant Juelich},
  series = {Eurosun 2012 : Solar energy for a brighter future : conference proceedings : Rijeka, 18.-22.09.2012},
  booktitle = {Eurosun 2012 : Solar energy for a brighter future : conference proceedings : Rijeka, 18.-22.09.2012},
  address   = {Rijeka},
  pages     = {ID 97},
  year      = {2012},
  language  = {en}
}
@article{ReisgenSchleserMokrovetal.2012,
  author    = {Reisgen, Uwe and Schleser, Markus and Mokrov, Oleg and Zabirov, Alexander and F{\"u}ssel, Uwe and Schnick, Michael and Hertel, Martin and Jaeckel, Sebastian},
  title     = {Modelling and visualisation of the GMA process},
  series = {Welding and Cutting},
  volume    = {11},
  journal   = {Welding and Cutting},
  number    = {4},
  publisher = {DVS Verlag},
  address   = {D{\"u}sseldorf},
  issn      = {1612-3433},
  pages     = {242 -- 249},
  year      = {2012},
  language  = {en}
}
@article{BohrnStuetzFuchsetal.2012,
  author    = {Bohrn, U. and St{\"u}tz, E. and Fuchs, K. and Fleischer, M. and Sch{\"o}ning, Michael Josef and Wagner, P.},
  title     = {Monitoring of irritant gas using a whole-cell-based sensor system},
  series = {Sensors and Actuators B: Chemical},
  volume    = {175},
  journal   = {Sensors and Actuators B: Chemical},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0925-4005},
  doi       = {10.1016/j.snb.2012.05.088},
  pages     = {208 -- 217},
  year      = {2012},
  abstract  = {Cell-based sensors for the detection of gases have long been underrepresented, due to the cellular requirement of being cultured in a liquid environment. In this work we established a cell-based gas biosensor for the detection of toxic substances in air, by adapting a commercial sensor chip (Bionas®), previously used for the measurement of pollutants in liquids. Cells of the respiratory tract (A549, RPMI 2650, V79), which survive at a gas phase in a natural context, are used as biological receptors. The physiological cell parameters acidification, respiration and morphology are continuously monitored in parallel. Ammonia was used as a highly water-soluble model gas to test the feasibility of the sensor system. Infrared measurements confirmed the sufficiency of the medium draining method. This sensor system provides a basis for many sensor applications such as environmental monitoring, building technology and public security.},
  language  = {en}
}
@inproceedings{SchoeningAbdelghani2012,
  author    = {Sch{\"o}ning, Michael Josef and Abdelghani, Adnane},
  title     = {Nanoscale Science and Technology (NS\&T'12) : Proceedings Book Humboldt Kolleg <2012, Tunisia> ; Tunisia, 17-19 March, 2012 / ed. by Michael J. Sch{\"o}ning ; Adnane Abdelghani},
  url       = {http://nbn-resolving.de/urn:nbn:de:hbz:a96-opus-3544},
  year      = {2012},
  abstract  = {Proceedings of the 2nd Humboldt Kolleg, Hammamet, Tunisia Organizer: Alexander von Humboldt Stiftung, Germany. pdf 184 p. Welcome Address Dear Participants, Welcome to the 2nd Humboldt Kolleg in "Nanoscale Science and Technology" (NS\&T'12) in Tunisia, sponsored by the "Alexander von Humboldt" foundation. The NS\&T'12 multidisciplinary scientific program includes seven "hot" topics dealing with "Nanoscale Science and Technology" covering basic and application-oriented research as well as industrial (market) aspects: - Molecular Biophyics, Spectroscopy Techniques, Imaging Microscopy - Nanomaterials Synthesis for Medicine and Bio-chemical Sensors - Nanostructures, Semiconductors, Photonics and Nanodevices - New Technologies in Market Industry - Environment, Electro-chemistry, Bio-polymers and Fuel Cells - Nanomaterials, Photovoltaic, Modelling, Quantum Physics - Microelectronics, Sensors Networks and Embedded Systems We are deeply indebted to all members of the Scientific Committee and General Chairs for joint Sessions and to all speakers and chairmen, who have dedicated invaluable time and efforts for the realization of this event. On behalf of the Organizing Committee, we are cordially inviting you to join the conference and hope that your stay will be fruitful, rewarding and enjoyable. Prof. Dr. Michael J. Sch{\"o}ning, Prof. Dr. Adnane Abdelghani},
  subject      = {Biosensor},
  language  = {en}
}
@article{ButenwegHoltschoppen2012,
  author    = {Butenweg, Christoph and Holtschoppen, Britta},
  title     = {Neuer VCI-Leitfaden f{\"u}r die erdbebensichere Auslegung von Industrieanlagen},
  series = {Bauingenieur : die richtungsweisende Zeitschrift im Bauingenieurswesen ; offizielle Zeitschrift der VDI-Gesellschaft Bautechnik},
  volume    = {Band 87},
  journal   = {Bauingenieur : die richtungsweisende Zeitschrift im Bauingenieurswesen ; offizielle Zeitschrift der VDI-Gesellschaft Bautechnik},
  publisher = {VDI Fachmedien},
  address   = {D{\"u}sseldorf},
  issn      = {1436-4867 (E-Journal); 0005-6650 (Print)},
  pages     = {S18},
  year      = {2012},
  language  = {de}
}
@article{StaatTrenzLohmannetal.2012,
  author    = {Staat, Manfred and Trenz, Eva and Lohmann, Philipp and Frotscher, Ralf and Klinge, Uwe and Tabaza, Ruth and Kirschner-Hermanns, Ruth},
  title     = {New measurements to compare soft tissue anchoring systems in pelvic floor surgery},
  series = {Journal of Biomedical Materials Research Part B: Applied Biomaterials},
  volume    = {100B},
  journal   = {Journal of Biomedical Materials Research Part B: Applied Biomaterials},
  number    = {4},
  publisher = {Wiley},
  address   = {Hoboken, NJ},
  issn      = {1552-4981},
  doi       = {10.1002/jbm.b.32654},
  pages     = {924 -- 933},
  year      = {2012},
  abstract  = {Suburethral slings as well as different meshes are widely used treating stress urinary incontinence and prolaps in women. With the development of MiniSlings and special meshes using less alloplastic material anchorage systems become more important to keep devices in place and to put some tension especially on the MiniSlings. To date, there are many different systems of MiniSlings of different companies on the market which differ in the structure of the used meshes and anchors. A new objective measurement method to compare different properties of MiniSling systems (mesh and anchor) is presented in this article. Ballistic gelatine acts as soft tissue surrogate. Significant differences in parameters like pull-out strength of anchors or shrinkage of meshes under loading conditions have been determined. The form and size of the anchors as well as the structural stability of the meshes are decisive for a proper integration. The tested anchorings sytems showed markedly different mechanical function at their respective load bearing capacity. As the stable fixation of the device in tissue is a prerequisite for a permanet reinforcement, the proposed test system permits further optimisation of anchor and mesh devices to improve the success of the surgical treatment},
  language  = {en}
}
@article{IkenKirsanovLeginetal.2012,
  author    = {Iken, Heiko and Kirsanov, D. and Legin, A. and Sch{\"o}ning, Michael Josef},
  title     = {Novel Thin-Film Polymeric Materials for the Detection of Heavy Metals},
  series = {Procedia Engineering},
  journal   = {Procedia Engineering},
  number    = {47},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1877-7058},
  doi       = {10.1016/j.proeng.2012.09.148},
  pages     = {322 -- 325},
  year      = {2012},
  abstract  = {A variety of transition metals, e.g., copper, zinc, cadmium, lead, etc. are widely used in industry as components for wires, coatings, alloys, batteries, paints and so on. The inevitable presence of transition metals in industrial processes implies the ambition of developing a proper analytical technique for their adequate monitoring. Most of these elements, especially lead and cadmium, are acutely toxic for biological organisms. Quantitative determination of these metals at low activity levels in different environmental and industrial samples is therefore a vital task. A promising approach to achieve an at-side or on-line monitoring on a miniaturized and cost efficient way is the combination of a common potentiometric sensor array with heavy metal-sensitive thin-film materials, like chalcogenide glasses and polymeric materials, respectively.},
  language  = {en}
}
@inproceedings{FunkeBoernerKeinzetal.2012,
  author    = {Funke, Harald and B{\"o}rner, Sebastian and Keinz, Jan and Kusterer, K. and Kroninger, D. and Kitajima, J. and Kazari, M. and Horikama, A.},
  title     = {Numerical and experimental characterization of low NOx Micromix combustion principle for industrial hydrogen gas turbine applications},
  series = {Proceedings of ASME Turbo Expo 2012},
  booktitle = {Proceedings of ASME Turbo Expo 2012},
  pages     = {11},
  year      = {2012},
  language  = {en}
}