@inproceedings{GrundmannBauerBodenetal.2019, author = {Grundmann, Jan Thimo and Bauer, Waldemar and Boden, Ralf and Ceriotti, Matteo and Chand, Suditi and Cordero, Federico and Dachwald, Bernd and Dumont, Etienne and Grimm, Christian D. and Heiligers, Jeannette and Herč{\´i}k, David and H{\´e}rique, Alain and Ho, Tra-Mi and Jahnke, Rico and Kofman, Wlodek and Lange, Caroline and Lichtenheldt, Roy and McInnes, Colin and Meß, Jan-Gerd and Mikschl, Tobias and Mikulz, Eugen and Montenegro, Sergio and Moore, Iain and Pelivan, Ivanka and Peloni, Alessandro and Plettemeier, Dirk and Quantius, Dominik and Reershemius, Siebo and Renger, Thomas and Riemann, Johannes and Rogez, Yves and Ruffer, Michael and Sasaki, Kaname and Schmitz, Nicole and Seboldt, Wolfgang and Seefeldt, Patric and Spietz, Peter and Spr{\"o}witz, Tom and Sznajder, Maciej and T{\´o}th, Norbert and Vergaaij, Merel and Viavattene, Giulia and Wejmo, Elisabet and Wiedemann, Carsten and Wolff, Friederike and Ziach, Christian}, title = {Flights are ten a sail - Re-use and commonality in the design and system engineering of small spacecraft solar sail missions with modular hardware for responsive and adaptive exploration}, series = {70th International Astronautical Congress (IAC)}, booktitle = {70th International Astronautical Congress (IAC)}, isbn = {9781713814856}, pages = {1 -- 7}, year = {2019}, language = {en} } @incollection{DachwaldOhndorf2019, author = {Dachwald, Bernd and Ohndorf, Andreas}, title = {Global optimization of continuous-thrust trajectories using evolutionary neurocontrol}, series = {Modeling and Optimization in Space Engineering}, booktitle = {Modeling and Optimization in Space Engineering}, publisher = {Springer}, address = {Cham}, isbn = {978-3-030-10501-3}, doi = {10.1007/978-3-030-10501-3_2}, pages = {33 -- 57}, year = {2019}, abstract = {Searching optimal continuous-thrust trajectories is usually a difficult and time-consuming task. The solution quality of traditional optimal-control methods depends strongly on an adequate initial guess because the solution is typically close to the initial guess, which may be far from the (unknown) global optimum. Evolutionary neurocontrol attacks continuous-thrust optimization problems from the perspective of artificial intelligence and machine learning, combining artificial neural networks and evolutionary algorithms. This chapter describes the method and shows some example results for single- and multi-phase continuous-thrust trajectory optimization problems to assess its performance. Evolutionary neurocontrol can explore the trajectory search space more exhaustively than a human expert can do with traditional optimal-control methods. Especially for difficult problems, it usually finds solutions that are closer to the global optimum. Another fundamental advantage is that continuous-thrust trajectories can be optimized without an initial guess and without expert supervision.}, language = {en} } @article{LeschingerBeschAydinetal.2019, author = {Leschinger, Tim and Besch, Katharina and Aydin, Cansu and Staat, Manfred and Scaal, Martin and M{\"u}ller, Lars Peter and Wegmann, Kilian}, title = {Irreparable rotator cuff tears: a biomechanical comparison of superior capsuloligamentous complex reconstruction techniques and an interposition graft technique}, series = {The Orthopaedic Journal of Sports Medicine}, volume = {7}, journal = {The Orthopaedic Journal of Sports Medicine}, number = {8}, doi = {10.1177/2325967119864590}, pages = {1 -- 5}, year = {2019}, language = {en} } @inproceedings{KetelhutGoellBraunsteinetal.2019, author = {Ketelhut, Maike and G{\"o}ll, Fabian and Braunstein, Bjoern and Albracht, Kirsten and Abel, Dirk}, title = {Iterative learning control of an industrial robot for neuromuscular training}, series = {2019 IEEE Conference on Control Technology and Applications}, booktitle = {2019 IEEE Conference on Control Technology and Applications}, publisher = {IEEE}, address = {New York}, isbn = {978-1-7281-2767-5 (ePub)}, doi = {10.1109/CCTA.2019.8920659}, pages = {7 Seiten}, year = {2019}, abstract = {Effective training requires high muscle forces potentially leading to training-induced injuries. Thus, continuous monitoring and controlling of the loadings applied to the musculoskeletal system along the motion trajectory is required. In this paper, a norm-optimal iterative learning control algorithm for the robot-assisted training is developed. The algorithm aims at minimizing the external knee joint moment, which is commonly used to quantify the loading of the medial compartment. To estimate the external knee joint moment, a musculoskeletal lower extremity model is implemented in OpenSim and coupled with a model of an industrial robot and a force plate mounted at its end-effector. The algorithm is tested in simulation for patients with varus, normal and valgus alignment of the knee. The results show that the algorithm is able to minimize the external knee joint moment in all three cases and converges after less than seven iterations.}, language = {en} } @article{MeyerGaalenLeschingeretal.2019, author = {Meyer, Carolin and Gaalen, Kerstin van and Leschinger, Tim and Scheyerer, Max J. and Neiss, Wolfram F. and Staat, Manfred and M{\"u}ller, Lars P. and Wegmann, Kilian}, title = {Kyphoplasty of Osteoporotic Fractured Vertebrae: A Finite Element Analysis about Two Types of Cement}, series = {BioMed Research International}, journal = {BioMed Research International}, doi = {10.1155/2019/9232813}, pages = {Article ID 9232813}, year = {2019}, language = {en} } @phdthesis{Tran2019, author = {Tran, Ngoc Trinh}, title = {Limit and Shakedown analysis of structures under stochastic conditions}, publisher = {Technische Universit{\"a}t Braunschweig}, address = {Braunschweig}, doi = {10.24355/dbbs.084-201902121135-0}, pages = {166 S.}, year = {2019}, language = {en} } @article{CampenKowalskiLyonsetal.2019, author = {Campen, R. and Kowalski, Julia and Lyons, W.B. and Tulaczyk, S. and Dachwald, Bernd and Pettit, E. and Welch, K. A. and Mikucki, J.A.}, title = {Microbial diversity of an Antarctic subglacial community and high-resolution replicate sampling inform hydrological connectivity in a polar desert}, series = {Environmental Microbiology}, journal = {Environmental Microbiology}, number = {accepted article}, publisher = {Wiley}, address = {Weinheim}, issn = {1462-2920}, doi = {10.1111/1462-2920.14607}, year = {2019}, language = {en} } @article{JungStaat2019, author = {Jung, Alexander and Staat, Manfred}, title = {Modeling and simulation of human induced pluripotent stem cell-derived cardiac tissue}, series = {GAMM - Mitteilungen der Gesellschaft f{\"u}r Angewandte Mathematik und Mechanik}, volume = {42}, journal = {GAMM - Mitteilungen der Gesellschaft f{\"u}r Angewandte Mathematik und Mechanik}, number = {4}, publisher = {Wiley}, address = {Weinheim}, issn = {1522-2608}, doi = {10.1002/gamm.201900002}, pages = {11 Seiten}, year = {2019}, language = {en} } @inproceedings{RamanJungHorvathetal.2019, author = {Raman, Aravind Hariharan and Jung, Alexander and Horv{\´a}th, Andr{\´a}s and Becker, Nadine and Staat, Manfred}, title = {Modification of a computer model of human stem cell-derived cardiomyocyte electrophysiology based on Patch-Clamp measurements}, series = {3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH Aachen}, booktitle = {3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH Aachen}, editor = {Staat, Manfred and Erni, Daniel}, publisher = {Universit{\"a}t Duisburg-Essen}, address = {Duisburg}, organization = {MedTech Symposium}, isbn = {978-3-940402-22-6}, doi = {10.17185/duepublico/48750}, pages = {10 -- 11}, year = {2019}, abstract = {Human induced pluripotent stem cells (hiPSCs) have shown to be promising in disease studies and drug screenings [1]. Cardiomyocytes derived from hiPSCs have been extensively investigated using patch-clamping and optical methods to compare their electromechanical behaviour relative to fully matured adult cells. Mathematical models can be used for translating findings on hiPSCCMs to adult cells [2] or to better understand the mechanisms of various ion channels when a drug is applied [3,4]. Paci et al. (2013) [3] developed the first model of hiPSC-CMs, which they later refined based on new data [3]. The model is based on iCells® (Fujifilm Cellular Dynamics, Inc. (FCDI), Madison WI, USA) but major differences among several cell lines and even within a single cell line have been found and motivate an approach for creating sample-specific models. We have developed an optimisation algorithm that parameterises the conductances (in S/F=Siemens/Farad) of the latest Paci et al. model (2018) [5] using current-voltage data obtained in individual patch-clamp experiments derived from an automated patch clamp system (Patchliner, Nanion Technologies GmbH, Munich).}, language = {en} } @article{AlbannaLuekeSchubertetal.2019, author = {Albanna, Walid and L{\"u}ke, Jan Niklas and Schubert, Gerrit Alexander and Dibu{\´e}-Adjei, Maxine and Kotliar, Konstantin and Hescheler, J{\"u}rgen and Clusmann, Hans and Steiger, Hans-Jakob and H{\"a}nggi, Daniel and Kamp, Marcel A. and Schneider, Toni and Neumaier, Felix}, title = {Modulation of Ca v 2.3 channels by unconjugated bilirubin (UCB) - Candidate mechanism for UCB-induced neuromodulation and neurotoxicity}, series = {Molecular and Cellular Neuroscience}, volume = {96}, journal = {Molecular and Cellular Neuroscience}, number = {4}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1044-7431}, doi = {10.1016/j.mcn.2019.03.003}, pages = {35 -- 46}, year = {2019}, language = {en} }