@article{StreunLarueParletal.2009, author = {Streun, M. and Larue, H. and Parl, C. and Ziemons, Karl}, title = {A compact PET detector readout using charge-to-time conversion}, series = {2009 IEEE Nuclear Science Symposium Conference Record (NSS/MIC)}, journal = {2009 IEEE Nuclear Science Symposium Conference Record (NSS/MIC)}, publisher = {IEEE}, address = {New York}, isbn = {1082-3654}, pages = {1868 -- 1870}, year = {2009}, abstract = {The readout of gamma detectors is considerably simplified when the event intensity is encoded as a pulse width (Pulse Width Modulation, PWM). Time-to-Digital-Converters (TDC) replace the conventional ADCs and multiple TDCs can be realized easily in one PLD chip (Programmable Logic Device). The output of a PWM stage is only one digital signal per channel which is well suited for transport so that further processing can be performed apart from the detector. This is particularly interesting for large systems with high channel density (e.g. high resolution scanners). In this work we present a circuit with a linear transfer function that requires a minimum of components by performing the PWM already in the preamp stage. This allows a very compact and also cost-efficient implementation of the front-end electronics.}, language = {en} } @article{ScheerWilson2016, author = {Scheer, Nico and Wilson, Ian D.}, title = {A comparison between genetically humanized and chimeric liver humanized mouse models for studies in drug metabolism and toxicity}, series = {Drug Discovery Today}, volume = {21}, journal = {Drug Discovery Today}, number = {2}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1359-6446}, doi = {10.1016/j.drudis.2015.09.002}, pages = {250 -- 263}, year = {2016}, abstract = {Mice that have been genetically humanized for proteins involved in drug metabolism and toxicity and mice engrafted with human hepatocytes are emerging and promising in vivo models for an improved prediction of the pharmacokinetic, drug-drug interaction and safety characteristics of compounds in humans. The specific advantages and disadvantages of these models should be carefully considered when using them for studies in drug discovery and development. Here, an overview on the corresponding genetically humanized and chimeric liver humanized mouse models described to date is provided and illustrated with examples of their utility in drug metabolism and toxicity studies. We compare the strength and weaknesses of the two different approaches, give guidance for the selection of the appropriate model for various applications and discuss future trends and perspectives.}, language = {en} } @article{GerhardtCooperWhitbreadetal.1985, author = {Gerhardt, Hans Joachim and Cooper, K.-R. and Whitbread, R. and Gary, K.-P. (u.a.)}, title = {A comparison of aerodynamic drag measurements on model trucks in closed-jet and open-jet wind tunnels}, pages = {261 -- 274}, year = {1985}, language = {en} } @article{BhattaraiStaat2019, author = {Bhattarai, Aroj and Staat, Manfred}, title = {A computational study of organ relocation after laparoscopic pectopexy to repair posthysterectomy vaginal vault prolapse}, series = {Computer Methods in Biomechanics and Biomedical Engineering: Imaging \& Visualization}, journal = {Computer Methods in Biomechanics and Biomedical Engineering: Imaging \& Visualization}, publisher = {Taylor \& Francis}, address = {London}, issn = {2168-1171}, doi = {10.1080/21681163.2019.1670095}, year = {2019}, language = {en} } @article{DigelDachwaldArtmannetal.2009, author = {Digel, Ilya and Dachwald, Bernd and Artmann, Gerhard and Linder, Peter and Funke, O.}, title = {A concept of a probe for particle analysis and life detection in icy environments}, pages = {1 -- 24}, year = {2009}, language = {en} } @article{Koehler2020, author = {K{\"o}hler, Klemens}, title = {A conflict theory perspective of IT attacks - consequences for IT security education}, number = {Preprint}, year = {2020}, abstract = {Cyberspace is "the environment formed by physical and non-physical components to store, modify, and exchange data using computer networks" (NATO CCDCOE). Beyond that, it is an environment where people interact. IT attacks are hostile, non-cooperative interactions that can be described with conflict theory. Applying conflict theory to IT security leads to different objectives for end-user education, requiring different formats like agency-based competence developing games.}, language = {en} } @article{DitzhausGaigall2018, author = {Ditzhaus, Marc and Gaigall, Daniel}, title = {A consistent goodness-of-fit test for huge dimensional and functional data}, series = {Journal of Nonparametric Statistics}, volume = {30}, journal = {Journal of Nonparametric Statistics}, number = {4}, publisher = {Taylor \& Francis}, address = {Abingdon}, issn = {1029-0311}, doi = {10.1080/10485252.2018.1486402}, pages = {834 -- 859}, year = {2018}, abstract = {A nonparametric goodness-of-fit test for random variables with values in a separable Hilbert space is investigated. To verify the null hypothesis that the data come from a specific distribution, an integral type test based on a Cram{\´e}r-von-Mises statistic is suggested. The convergence in distribution of the test statistic under the null hypothesis is proved and the test's consistency is concluded. Moreover, properties under local alternatives are discussed. Applications are given for data of huge but finite dimension and for functional data in infinite dimensional spaces. A general approach enables the treatment of incomplete data. In simulation studies the test competes with alternative proposals.}, language = {en} } @article{BreitbachSchubert2004, author = {Breitbach, Gerd and Schubert, F.}, title = {A contribution to stress prediction in coatings for gas turbine blades}, series = {Archive of applied mechanics. 73 (2004), H. 9-10}, journal = {Archive of applied mechanics. 73 (2004), H. 9-10}, isbn = {0939-1533}, pages = {682 -- 689}, year = {2004}, language = {en} } @article{GerlingPoolPredel1983, author = {Gerling, Ulrich and Pool, M. J. and Predel, Bruno}, title = {A contribution to the associate model for binary liquid alloys = Ein Beitrag zum Assoziat-Modell f{\"u}r bin{\"a}re fl{\"u}ssige Legierungen}, series = {Zeitschrift f{\"u}r Metallkunde : international journal of materials research and advanced techniques. Bd. 74, H. 9}, journal = {Zeitschrift f{\"u}r Metallkunde : international journal of materials research and advanced techniques. Bd. 74, H. 9}, issn = {0044-3093 ; 0179-4841}, pages = {616 -- 619}, year = {1983}, language = {en} } @article{HaegerBongaertsSiegert2022, author = {Haeger, Gerrit and Bongaerts, Johannes and Siegert, Petra}, title = {A convenient ninhydrin assay in 96-well format for amino acid-releasing enzymes using an air-stable reagent}, series = {Analytical Biochemistry}, journal = {Analytical Biochemistry}, number = {624}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1096-0309}, doi = {10.1016/j.ab.2022.114819}, pages = {Artikel 114819}, year = {2022}, abstract = {An improved and convenient ninhydrin assay for aminoacylase activity measurements was developed using the commercial EZ Nin™ reagent. Alternative reagents from literature were also evaluated and compared. The addition of DMSO to the reagent enhanced the solubility of Ruhemann's purple (RP). Furthermore, we found that the use of a basic, aqueous buffer enhances stability of RP. An acidic protocol for the quantification of lysine was developed by addition of glacial acetic acid. The assay allows for parallel processing in a 96-well format with measurements microtiter plates.}, language = {en} }