@article{BandodkarMolinnusMirzaetal.2014, author = {Bandodkar, Amay J. and Molinnus, Denise and Mirza, Omar and Guinovart, Tomas and Windmiller, Joshua R. and Valdes-Ramirez, Gabriela and Andrade, Francisco J. and Sch{\"o}ning, Michael Josef and Wang, Joseph}, title = {Epidermal tattoo potentiometric sodium sensors with wireless signal transduction for continuous non-invasive sweat monitoring}, series = {Biosensors and bioelectronics}, volume = {54}, journal = {Biosensors and bioelectronics}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1873-4235 (E-Journal); 0956-5663 (Print)}, doi = {10.1016/j.bios.2013.11.039}, pages = {603 -- 609}, year = {2014}, abstract = {This article describes the fabrication, characterization and application of an epidermal temporary-transfer tattoo-based potentiometric sensor, coupled with a miniaturized wearable wireless transceiver, for real-time monitoring of sodium in the human perspiration. Sodium excreted during perspiration is an excellent marker for electrolyte imbalance and provides valuable information regarding an individual's physical and mental wellbeing. The realization of the new skin-worn non-invasive tattoo-like sensing device has been realized by amalgamating several state-of-the-art thick film, laser printing, solid-state potentiometry, fluidics and wireless technologies. The resulting tattoo-based potentiometric sodium sensor displays a rapid near-Nernstian response with negligible carryover effects, and good resiliency against various mechanical deformations experienced by the human epidermis. On-body testing of the tattoo sensor coupled to a wireless transceiver during exercise activity demonstrated its ability to continuously monitor sweat sodium dynamics. The real-time sweat sodium concentration was transmitted wirelessly via a body-worn transceiver from the sodium tattoo sensor to a notebook while the subjects perspired on a stationary cycle. The favorable analytical performance along with the wearable nature of the wireless transceiver makes the new epidermal potentiometric sensing system attractive for continuous monitoring the sodium dynamics in human perspiration during diverse activities relevant to the healthcare, fitness, military, healthcare and skin-care domains.}, language = {en} } @article{GellertButenweg2014, author = {Gellert, Christoph and Butenweg, Christoph}, title = {Seismic analysis of masonry structures in German earthquake zones according to DIN EN 1998-1}, series = {Mauerwerk : European journal of masonry}, volume = {18}, journal = {Mauerwerk : European journal of masonry}, number = {3-4}, publisher = {Ernst \& Sohn}, address = {Berlin}, issn = {1437-1022 (E-Journal); 1432-3427 (Print)}, doi = {10.1002/dama.201400626}, pages = {188 -- 196}, year = {2014}, abstract = {Die Erdbeben in Albstadt 1978 (Magnitude 5,7), Roermond 1992 (Magnitude 5,9) oder in Waldkirch 2004 (Magnitude 5,1) haben verdeutlicht, dass die erdbebensichere Auslegung von Mauerwerksbauten auch in Deutschland von großer Bedeutung ist. Bereits im Jahr 1981 wurde die DIN 4149 (1981) "Bauten in deutschen Erdbebengebieten - Lastannahmen, Bemessung und Ausf{\"u}hrung {\"u}blicher Hochbauten" eingef{\"u}hrt, in der aber f{\"u}r Mauerwerksbauten nur wenige Anforderungen gestellt wurden. Diese Norm wurde durch den NABau-Arbeitsausschuss "Erdbeben; Sonderfragen" des Deutschen Instituts f{\"u}r Normung e.V. (DIN) auf Grundlage des Eurocode 8 (2004) vollst{\"a}ndig {\"u}berarbeitet und durch die DIN 4149 (2005) abgel{\"o}st, die umfangreiche Regelungen f{\"u}r die seismische Auslegung von Mauerwerksbauten enth{\"a}lt. Mittlerweile liegen die DIN EN 1998-1 (2010) und der Nationale Anhang DIN EN 1998-1/NA (2011) vor, die nach Einarbeitung der Ergebnisse der durchgef{\"u}hrten Anwendungserprobung bauaufsichtlich eingef{\"u}hrt und die DIN 4149 (2005) ersetzen werden. Der folgende Beitrag gibt einen {\"U}berblick {\"u}ber die seismische Berechnung und Bemessung von Mauerwerksbauten nach dem europ{\"a}ischen Regelwerk und illustriert deren Anwendung an einem baupraktischen Beispiel.}, language = {de} } @article{ThomasWassenberg2014, author = {Thomas, Axel and Wassenberg, Gerd}, title = {Erfolgreich sein im Kampf um die besten Talente : Employer Branding}, series = {Wirtschaftliche Nachrichten der Industrie- und Handelskammer Aachen}, journal = {Wirtschaftliche Nachrichten der Industrie- und Handelskammer Aachen}, publisher = {IHK Aachen}, address = {Aachen}, year = {2014}, language = {de} } @article{PyschnyDoeringFeldmann2014, author = {Pyschny, D. and D{\"o}ring, Bernd and Feldmann, M.}, title = {Ermittlung der thermischen Leistungsf{\"a}higkeit des neuartigen multifunktionalen Verbunddeckensystems InaDeck}, series = {Bauingenieur : die richtungsweisende Zeitschrift im Bauingenieurswesen}, volume = {89}, journal = {Bauingenieur : die richtungsweisende Zeitschrift im Bauingenieurswesen}, number = {3}, publisher = {VDI Fachmedien}, address = {D{\"u}sseldorf}, issn = {0005-6650}, pages = {116 -- 124}, year = {2014}, language = {de} } @article{MeyerButenwegFehling2014, author = {Meyer, Udo and Butenweg, Christoph and Fehling, Ekkehard}, title = {EU-Projekt INSYSME : innovative Systeme f{\"u}r erdbebentaugliche Ausfachungsw{\"a}nde aus Ziegelmauerwerk}, series = {Bauingenieur : die richtungsweisende Zeitschrift im Bauingenieurswesen ; offizielle Zeitschrift der VDI-Gesellschaft Bautechnik. Beilage: D-A-CH-Mitteilungsblatt}, volume = {89 (2014)}, journal = {Bauingenieur : die richtungsweisende Zeitschrift im Bauingenieurswesen ; offizielle Zeitschrift der VDI-Gesellschaft Bautechnik. Beilage: D-A-CH-Mitteilungsblatt}, number = {April}, publisher = {VDI Fachmedien}, address = {D{\"u}sseldorf}, issn = {1436-4867 (E-Journal); 0005-6650 (Print)}, pages = {S14 -- S15}, year = {2014}, language = {de} } @article{ButenwegMeyerFehling2014, author = {Butenweg, Christoph and Meyer, Udo and Fehling, Ekkehard}, title = {EU-Projekt INSYSME: Innovative Techniken f{\"u}r erdbebensichere Ausfachungsw{\"a}nde aus Ziegelmauerwerk in Stahlbetonrahmentragwerken}, series = {Mauerwerk : European journal of masonry}, volume = {18}, journal = {Mauerwerk : European journal of masonry}, number = {2}, publisher = {Ernst \& Sohn}, address = {Berlin}, issn = {1437-1022 (E-Journal); 1432-3427 (Print)}, doi = {10.1002/dama.201400612}, pages = {78 -- 81}, year = {2014}, abstract = {Am 1. Oktober 2013 ist das auf drei Jahre angelegte EU-Forschungsprojekt INSYSME - Innovative Systeme f{\"u}r erdbebentaugliche Ausfachungsw{\"a}nde aus Ziegelmauerwerk in Stahlbetonrahmentragwerken - gestartet. Unter der Koordination der Universit{\"a}t Padua beteiligen sich 16 Partner aus sechs europ{\"a}ischen L{\"a}ndern (Deutschland, Griechenland, Italien, Portugal, Rum{\"a}nien, T{\"u}rkei). Als deutsche Partner nehmen die Arbeitsgemeinschaft Mauerziegel aus Bonn, die Universit{\"a}t Kassel sowie das Ingenieurb{\"u}ro SDA-engineering GmbH aus Herzogenrath, teil. Ziel der deutschen Partner ist die Entwicklung von innovativen Ausfachungssystemen aus monolithischem w{\"a}rmed{\"a}mmenden Ziegelmauerwerk, mit denen nicht nur eine erh{\"o}hte Erdbebensicherheit, sondern auch die sichere Erf{\"u}llung der steigenden Anforderungen aus Windbeanspruchungen gew{\"a}hrleistet werden k{\"o}nnen. Die Forschungsergebnisse sollen vom Partner SDA-engineering GmbH in die bereits seit einigen Jahren verf{\"u}gbare Softwarel{\"o}sung MINEA [1] integriert werden. Weitere Informationen stehen auf den Websites des Projektes [2] zur Verf{\"u}gung. Im vorliegenden Beitrag werden nach einer kurzen thematischen Einf{\"u}hrung die Ergebnisse von Tastversuchen an senkrecht zur Ebene belasteten Ausfachungsw{\"a}nden aus Planziegelmauerwerk vorgestellt. Im Anschluss wird das geplante Arbeitsprogramm der deutschen Partner im Projekt INSYSME beschrieben.}, language = {de} } @article{SalpatiChuChenetal.2014, author = {Salpati, Laurent and Chu, Xiaoyan and Chen, Liangfu and Prasad, Bhagwat and Dallas, Shannon and Evers, Raymond and Mamaril-Fishman, Donna and Geier, Ethan G. and Kehler, Jonathan and Kunta, Jeevan and Mezler, Mario and Laplanche, Loic and Pang, Jodie and Soars, Matthew G. and Unadkat, Jashvant D. and van Waterschoot, Robert A.B. and Yabut, Jocelyn and Schinkel, Alfred H. and Scheer, Nico and Rode, Anja}, title = {Evaluation of organic anion transporting polypeptide 1B1 and 1B3 humanized mice as a translational model to study the pharmacokinetics of statins}, series = {Drug Metabolism and Disposition}, volume = {42}, journal = {Drug Metabolism and Disposition}, number = {8}, publisher = {ASPET}, address = {Bethesda, Md.}, issn = {1521-009X}, doi = {10.1124/dmd.114.057976}, pages = {1301 -- 1313}, year = {2014}, abstract = {Organic anion transporting polypeptide (Oatp) 1a/1b knockout and OATP1B1 and -1B3 humanized mouse models are promising tools for studying the roles of these transporters in drug disposition. Detailed characterization of these models will help to better understand their utility for predicting clinical outcomes. To advance this approach, we carried out a comprehensive analysis of these mouse lines by evaluating the compensatory changes in mRNA expression, quantifying the amounts of OATP1B1 and -1B3 protein by liquid chromatography-tandem mass spectrometry, and studying the active uptake in isolated hepatocytes and the pharmacokinetics of some prototypical substrates including statins. Major outcomes from these studies were 1) mostly moderate compensatory changes in only a few genes involved in drug metabolism and disposition, 2) a robust hepatic expression of OATP1B1 and -1B3 proteins in the respective humanized mouse models, and 3) functional activities of the human transporters in hepatocytes isolated from the humanized models with several substrates tested in vitro and with pravastatin in vivo. However, the expression of OATP1B1 and -1B3 in the humanized models did not significantly alter liver or plasma concentrations of rosuvastatin and pitavastatin compared with Oatp1a/1b knockout controls under the conditions used in our studies. Hence, although the humanized OATP1B1 and -1B3 mice showed in vitro and/or in vivo functional activity with some statins, further characterization of these models is required to define their potential use and limitations in the prediction of drug disposition and drug-drug interactions in humans.}, language = {en} } @article{LehnertzAnsmannBialonskietal.2014, author = {Lehnertz, Klaus and Ansmann, Gerrit and Bialonski, Stephan and Dickten, Henning and Geier, Christian and Porz, Stephan}, title = {Evolving networks in the human epileptic brain}, series = {Physica D: Nonlinear Phenomena}, volume = {267}, journal = {Physica D: Nonlinear Phenomena}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0167-2789}, doi = {10.1016/j.physd.2013.06.009}, pages = {7 -- 15}, year = {2014}, abstract = {Network theory provides novel concepts that promise an improved characterization of interacting dynamical systems. Within this framework, evolving networks can be considered as being composed of nodes, representing systems, and of time-varying edges, representing interactions between these systems. This approach is highly attractive to further our understanding of the physiological and pathophysiological dynamics in human brain networks. Indeed, there is growing evidence that the epileptic process can be regarded as a large-scale network phenomenon. We here review methodologies for inferring networks from empirical time series and for a characterization of these evolving networks. We summarize recent findings derived from studies that investigate human epileptic brain networks evolving on timescales ranging from few seconds to weeks. We point to possible pitfalls and open issues, and discuss future perspectives.}, language = {en} } @article{FunkeDickhoffKeinzetal.2014, author = {Funke, Harald and Dickhoff, J. and Keinz, Jan and Anis, H. A. and Parente, A. and Hendrick, P.}, title = {Experimental and numerical study of the micromix combustion principle applied for hydrogen and hydrogen-rich syngas as fuel with increased energy density for industrial gas turbine applications}, series = {Energy procedia}, journal = {Energy procedia}, number = {61}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1876-6102 (E-Journal)}, doi = {10.1016/j.egypro.2014.12.201}, pages = {1736 -- 1739}, year = {2014}, abstract = {The Dry Low NOx (DLN) Micromix combustion principle with increased energy density is adapted for the industrial gas turbine APU GTCP 36-300 using hydrogen and hydrogen-rich syngas with a composition of 90\%-Vol. hydrogen (H₂) and 10\%-Vol. carbon-monoxide (CO). Experimental and numerical studies of several combustor geometries for hydrogen and syngas show the successful advance of the DLN Micromix combustion from pure hydrogen to hydrogen-rich syngas. The impact of the different fuel properties on the combustion principle and aerodynamic flame stabilization design laws, flow field, flame structure and emission characteristics is investigated by numerical analysis using a hybrid Eddy Break Up combustion model and validated against experimental results.}, language = {en} } @article{FateriGebhardtThuemmleretal.2014, author = {Fateri, Miranda and Gebhardt, Andreas and Th{\"u}mmler, Stefan and Thurn, Laura}, title = {Experimental investigation on selective laser melting of glass}, series = {Physics procedia : 8th International Conference on Laser Assisted Net Shape Engineering LANE 2014}, volume = {56 (2014)}, journal = {Physics procedia : 8th International Conference on Laser Assisted Net Shape Engineering LANE 2014}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1875-3892 (E-Journal); 1875-3884 (Print)}, doi = {10.1016/j.phpro.2014.08.118}, pages = {357 -- 364}, year = {2014}, language = {en} }