@article{HaegerBongaertsSiegert2022, author = {Haeger, Gerrit and Bongaerts, Johannes and Siegert, Petra}, title = {A convenient ninhydrin assay in 96-well format for amino acid-releasing enzymes using an air-stable reagent}, series = {Analytical Biochemistry}, journal = {Analytical Biochemistry}, number = {624}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1096-0309}, doi = {10.1016/j.ab.2022.114819}, pages = {Artikel 114819}, year = {2022}, abstract = {An improved and convenient ninhydrin assay for aminoacylase activity measurements was developed using the commercial EZ Nin™ reagent. Alternative reagents from literature were also evaluated and compared. The addition of DMSO to the reagent enhanced the solubility of Ruhemann's purple (RP). Furthermore, we found that the use of a basic, aqueous buffer enhances stability of RP. An acidic protocol for the quantification of lysine was developed by addition of glacial acetic acid. The assay allows for parallel processing in a 96-well format with measurements microtiter plates.}, language = {en} } @article{TopcuMadabhushiStaat2022, author = {Top{\c{c}}u, Murat and Madabhushi, Gopal S.P. and Staat, Manfred}, title = {A generalized shear-lag theory for elastic stress transfer between matrix and fibres having a variable radius}, series = {International Journal of Solids and Structures}, volume = {239-240}, journal = {International Journal of Solids and Structures}, number = {Art. No. 111464}, publisher = {Elsevier}, address = {New York, NY}, issn = {0020-7683}, doi = {10.1016/j.ijsolstr.2022.111464}, year = {2022}, abstract = {A generalized shear-lag theory for fibres with variable radius is developed to analyse elastic fibre/matrix stress transfer. The theory accounts for the reinforcement of biological composites, such as soft tissue and bone tissue, as well as for the reinforcement of technical composite materials, such as fibre-reinforced polymers (FRP). The original shear-lag theory proposed by Cox in 1952 is generalized for fibres with variable radius and with symmetric and asymmetric ends. Analytical solutions are derived for the distribution of axial and interfacial shear stress in cylindrical and elliptical fibres, as well as conical and paraboloidal fibres with asymmetric ends. Additionally, the distribution of axial and interfacial shear stress for conical and paraboloidal fibres with symmetric ends are numerically predicted. The results are compared with solutions from axisymmetric finite element models. A parameter study is performed, to investigate the suitability of alternative fibre geometries for use in FRP.}, language = {en} } @article{BaringhausGaigall2022, author = {Baringhaus, Ludwig and Gaigall, Daniel}, title = {A goodness-of-fit test for the compound Poisson exponential model}, series = {Journal of Multivariate Analysis}, volume = {195}, journal = {Journal of Multivariate Analysis}, number = {Article 105154}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0047-259X}, doi = {10.1016/j.jmva.2022.105154}, year = {2022}, abstract = {On the basis of bivariate data, assumed to be observations of independent copies of a random vector (S,N), we consider testing the hypothesis that the distribution of (S,N) belongs to the parametric class of distributions that arise with the compound Poisson exponential model. Typically, this model is used in stochastic hydrology, with N as the number of raindays, and S as total rainfall amount during a certain time period, or in actuarial science, with N as the number of losses, and S as total loss expenditure during a certain time period. The compound Poisson exponential model is characterized in the way that a specific transform associated with the distribution of (S,N) satisfies a certain differential equation. Mimicking the function part of this equation by substituting the empirical counterparts of the transform we obtain an expression the weighted integral of the square of which is used as test statistic. We deal with two variants of the latter, one of which being invariant under scale transformations of the S-part by fixed positive constants. Critical values are obtained by using a parametric bootstrap procedure. The asymptotic behavior of the tests is discussed. A simulation study demonstrates the performance of the tests in the finite sample case. The procedure is applied to rainfall data and to an actuarial dataset. A multivariate extension is also discussed.}, language = {en} } @article{UysalFiratCreutzetal.2022, author = {Uysal, Karya and Firat, Ipek Serat and Creutz, Till and Aydin, Inci Cansu and Artmann, Gerhard and Teusch, Nicole and Temiz Artmann, Ayseg{\"u}l}, title = {A novel in vitro wound healing assay using free-standing, ultra-thin PDMS membranes}, series = {membranes}, volume = {2023}, journal = {membranes}, number = {13(1)}, publisher = {MDPI}, address = {Basel}, doi = {10.3390/membranes13010022}, pages = {Artikel 22}, year = {2022}, abstract = {Advances in polymer science have significantly increased polymer applications in life sciences. We report the use of free-standing, ultra-thin polydimethylsiloxane (PDMS) membranes, called CellDrum, as cell culture substrates for an in vitro wound model. Dermal fibroblast monolayers from 28- and 88-year-old donors were cultured on CellDrums. By using stainless steel balls, circular cell-free areas were created in the cell layer (wounding). Sinusoidal strain of 1 Hz, 5\% strain, was applied to membranes for 30 min in 4 sessions. The gap circumference and closure rate of un-stretched samples (controls) and stretched samples were monitored over 4 days to investigate the effects of donor age and mechanical strain on wound closure. A significant decrease in gap circumference and an increase in gap closure rate were observed in trained samples from younger donors and control samples from older donors. In contrast, a significant decrease in gap closure rate and an increase in wound circumference were observed in the trained samples from older donors. Through these results, we propose the model of a cell monolayer on stretchable CellDrums as a practical tool for wound healing research. The combination of biomechanical cell loading in conjunction with analyses such as gene/protein expression seems promising beyond the scope published here.}, language = {en} } @article{PfaffEnningSutter2022, author = {Pfaff, Raphael and Enning, Manfred and Sutter, Stefan}, title = {A risk‑based approach to automatic brake tests for rail freight service: incident analysis and realisation concept}, series = {SN Applied Sciences}, volume = {4}, journal = {SN Applied Sciences}, number = {4}, publisher = {Springer}, address = {Cham}, issn = {2523-3971}, doi = {10.1007/s42452-022-05007-x}, pages = {1 -- 14}, year = {2022}, abstract = {This study reviews the practice of brake tests in freight railways, which is time consuming and not suitable to detect certain failure types. Public incident reports are analysed to derive a reasonable brake test hardware and communication architecture, which aims to provide automatic brake tests at lower cost than current solutions. The proposed solutions relies exclusively on brake pipe and brake cylinder pressure sensors, a brake release position switch as well as radio communication via standard protocols. The approach is embedded in the Wagon 4.0 concept, which is a holistic approach to a smart freight wagon. The reduction of manual processes yields a strong incentive due to high savings in manual labour and increased productivity.}, language = {en} } @book{BloeckerEsserHengstebecketal.2022, author = {Bl{\"o}cker, Lene Christin and Esser, Julia and Hengstebeck, Pauline and Venrath, Carolin and Scholtes, Eva}, title = {Aachener Online-Schriften Wirtschaft und Recht. Band 4. 01/2022}, editor = {Kroll-Ludwigs, Kathrin and Bernecker, Andreas and Bassen-Metz, Yasmine and Eggert, Mathias and Fritz, Thomas and Golland, Alexander and H{\"o}hne, Tim and Tran, Duc Hung and Vogt, J{\"u}rgen}, publisher = {FH Aachen / Fachbereich Wirtschaftswissenschaften}, address = {Aachen}, publisher = {Fachhochschule Aachen}, pages = {345 Seiten}, year = {2022}, abstract = {Inhaltsverzeichnis - Bachelorarbeiten 1. The impact of the EU non-financial reporting directive on sustainability reporting practices of DAX 30 companies - Lene Christin Bl{\"o}cker 4 - 29 2. Kurzarbeit als Krisenbew{\"a}ltigungsinstrument - Die arbeitsrechtlichen Voraussetzungen f{\"u}r die wirksame Einf{\"u}hrung von Kurzarbeit - Julia Esser 30 - 87 3. Die virtuelle Hauptversammlung der Aktiengesellschaft - Notl{\"o}sung w{\"a}hrend der Corona-Pandemie oder dauerhafte Alternative? - Pauline Hengstebeck 88 - 152 4. Die psychische Gesundheit am Arbeitsplatz - Aktuelle Problematik, Ursachenforschung, Folgen, rechtliche Rahmenbedingungen und geeignete Pr{\"a}ventionsmaßnahmen aus Arbeitgebersicht - Carolin Venrath 153 - 224 Inhaltsverzeichnis - Masterarbeiten The influence of religion on the representation of women in politics - Eva Scholtes 225 - 345}, language = {de} } @book{BundrockKremersPankoketal.2022, author = {Bundrock, Ronja and Kremers, Nico and Pankok, Lennard and Weisheit, Theresa Maria and Spoede, Jasper}, title = {Aachener Online-Schriften Wirtschaft und Recht. Band 5. 02/2022}, editor = {Kroll-Ludwigs, Kathrin and Bernecker, Andreas and Bassen-Metz, Yasmine and Eggert, Mathias and Fritz, Thomas and Golland, Alexander and H{\"o}hne, Tim and Tran, Duc Hung and Vogt, J{\"u}rgen}, publisher = {FH Aachen / Fachbereich Wirtschaftswissenschaften}, address = {Aachen}, publisher = {Fachhochschule Aachen}, pages = {356 Seiten}, year = {2022}, abstract = {Inhaltsverzeichnis - Bachelorarbeiten 1. Testamentsgestaltung bei Patchworkfamilien - L{\"o}sungsans{\"a}tze f{\"u}r typische Praxisprobleme unter Ber{\"u}cksichtigung der Interessenlagen der Parteien - Ronja Bundrock 4 - 58 2. Die Haftung des AG-Vorstands gegen{\"u}ber der Gesellschaft in unterneh- mensinternen und -externen Krisen - Nico Kremers 59 - 122 3. The Relationship of the Ex-Ante Uncertainty about the Value of a Stock and its IPO Underpricing - An Analysis of the German Market - Lennard Pankok 123 - 179 4. Attractiveness Bias in Venture Capital - An Analysis of Investor Decision Making in "Die H{\"o}hle der L{\"o}wen" - Theresa Maria Weisheit 180 - 242 Inhaltsverzeichnis - Masterarbeiten Erh{\"o}hung der Energieautarkie in der Backbranche - Anwendung von bidi- rektionalem Laden und dessen Auswirkungen auf die Gesch{\"a}ftsprozesse und Informationssysteme - Jasper Spoede 243 - 355}, language = {de} } @inproceedings{EvansBraunUlmeretal.2022, author = {Evans, Benjamin and Braun, Sebastian and Ulmer, Jessica and Wollert, J{\"o}rg}, title = {AAS implementations - current problems and solutions}, series = {20th International Conference on Mechatronics - Mechatronika (ME)}, booktitle = {20th International Conference on Mechatronics - Mechatronika (ME)}, publisher = {IEEE}, address = {New York, NY}, isbn = {978-1-6654-1040-3}, doi = {10.1109/ME54704.2022.9982933}, pages = {6 Seiten}, year = {2022}, abstract = {The fourth industrial revolution presents a multitude of challenges for industries, one of which being the increased flexibility required of manufacturing lines as a result of increased consumer demand for individualised products. One solution to tackle this challenge is the digital twin, more specifically the standardised model of a digital twin also known as the asset administration shell. The standardisation of an industry wide communications tool is a critical step in enabling inter-company operations. This paper discusses the current state of asset administration shells, the frameworks used to host them and their problems that need to be addressed. To tackle these issues, we propose an event-based server capable of drastically reducing response times between assets and asset administration shells and a multi-agent system used for the orchestration and deployment of the shells in the field.}, language = {en} } @techreport{SiegertBongaertsWagneretal.2022, author = {Siegert, Petra and Bongaerts, Johannes and Wagner, Torsten and Sch{\"o}ning, Michael Josef and Selmer, Thorsten}, title = {Abschlussbericht zum Projekt zur {\"U}berwachung biotechnologischer Prozesse mittels Diacetyl-/Acetoin-Biosensor und Evaluierung von Acetoin-Reduktasen zur Verwendung in Biotransformationen}, address = {Aachen}, organization = {FH Aachen}, pages = {16 Seiten}, year = {2022}, language = {de} } @masterthesis{Guth2022, type = {Bachelor Thesis}, author = {Guth, Katharina}, title = {aco : eine digitale Anwendung zur Verbesserung der Lebensqualit{\"a}t von Neurodermitis-Patient:innen}, publisher = {FH Aachen}, address = {Aachen}, school = {Fachhochschule Aachen}, pages = {267 Seiten}, year = {2022}, abstract = {Neurodermitis hat in den letzten Jahrzehnten deutlich zugenommen. Etwa 10 bis 15 Prozent der Kinder und 2,5 bis 3,5 Prozent der Erwachsenen sind davon betroffen. F{\"u}r sie stellen Auswirkungen der Hautkrankheit auf K{\"o}rper und Psyche eine enorme Einschr{\"a}nkung der Lebensqualit{\"a}t dar. Die App „aco" m{\"o}chte Neurodermitis-Patient:Innen dabei unterst{\"u}tzen, ihre Behandlung selbst in die Hand zu nehmen. Eine ganzheitliche Therapie umfasst eben nicht nur Fachpersonen, sondern auch Patient:Innen selbst. Durch eine regelm{\"a}ßige Dokumentation erm{\"o}glicht die Anwendung eine aktive Auseinandersetzung mit der Krankheit. Triggerfaktoren werden ausgewertet und es wird Wissen {\"u}ber Behandlungsm{\"o}glichkeiten vermittelt. Zudem wird ein Austausch erm{\"o}glicht, der emotionale und praktische Unterst{\"u}tzung bieten soll. Damit m{\"o}chte „aco" Betroffenen eine M{\"o}glichkeit geben, das Ruder selbst in die Hand zu nehmen und leistet damit einen wichtigen Beitrag zur Therapie von Neurodermitis.}, language = {de} }