@article{SiepmannRupietta1993,
  author    = {Siepmann, Thomas and Rupietta, D.},
  title     = {Closer to the customer with computerized product support},
  series = {Technische Mitteilungen Krupp (1993)},
  journal   = {Technische Mitteilungen Krupp (1993)},
  address   = {Essen},
  year      = {1993},
  language  = {en}
}
@article{MeyerGranrathFeyerletal.2021,
  author    = {Meyer, Max-Arno and Granrath, Christian and Feyerl, G{\"u}nter and Richenhagen, Johannes and Kaths, Jakob and Andert, Jakob},
  title     = {Closed-loop platoon simulation with cooperative intelligent transportation systems based on vehicle-to-X communication},
  series = {Simulation Modelling Practice and Theory},
  volume    = {106},
  journal   = {Simulation Modelling Practice and Theory},
  number    = {Art. 102173},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1569-190X},
  doi       = {10.1016/j.simpat.2020.102173},
  year      = {2021},
  language  = {en}
}
@article{ZhangHeimbachScheeretal.2016,
  author    = {Zhang, Jin and Heimbach, Tycho and Scheer, Nico and Barve, Avantika and Li, Wenkui and Lin, Wen and He, Handan},
  title     = {Clinical Exposure Boost Predictions by Integrating Cytochrome P450 3A4-Humanized Mouse Studies With PBPK Modeling},
  series = {Journal of Pharmaceutical Sciences},
  volume    = {Volume 105},
  journal   = {Journal of Pharmaceutical Sciences},
  number    = {Issue 4},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0022-3549},
  doi       = {doi.org/10.1016/j.xphs.2016.01.021},
  pages     = {1398 -- 1404},
  year      = {2016},
  abstract  = {NVS123 is a poorly water-soluble protease 56 inhibitor in clinical development. Data from in vitro hepatocyte studies suggested that NVS123 is mainly metabolized by CYP3A4. As a consequence of limited solubility, NVS123 therapeutic plasma exposures could not be achieved even with high doses and optimized formulations. One approach to overcome NVS123 developability issues was to increase plasma exposure by coadministrating it with an inhibitor of CYP3A4 such as ritonavir. A clinical boost effect was predicted by using physiologically based pharmacokinetic (PBPK) modeling. However, initial boost predictions lacked sufficient confidence because a key parameter, fraction of drug metabolized by CYP3A4 (ƒₘCYP3A4), could not be estimated with accuracy on account of disconnects between in vitro and in vivo preclinical data. To accurately estimate ƒₘCYP3A4 in human, an in vivo boost effect study was conducted using CYP3A4-humanized mouse model which showed a 33- to 56-fold exposure boost effect. Using a top-down approach, human ƒₘCYP3A4 for NVS123 was estimated to be very high and included in the human PBPK modeling to support subsequent clinical study design. The combined use of the in vivo boost study in CYP3A4-humanized mouse model mice along with PBPK modeling accurately predicted the clinical outcome and identified a significant NVS123 exposure boost (∼42-fold increase) with ritonavir.},
  language  = {en}
}
@article{BehnamBeckerWeber2011,
  author    = {Behnam, S. and Becker, A. and Weber, Hans-Joachim},
  title     = {Clinical benefit and cost-efficiency of minimized perfusion circuits for extracorporeal circulation during cardiac surgery},
  series = {Zeitschrift f{\"u}r Herz-, Thorax- und Gef{\"a}ßchirurgie},
  volume    = {25},
  journal   = {Zeitschrift f{\"u}r Herz-, Thorax- und Gef{\"a}ßchirurgie},
  number    = {5},
  publisher = {Springer},
  address   = {Berlin},
  issn      = {0930-9225},
  pages     = {305 -- 306},
  year      = {2011},
  language  = {en}
}
@article{GrotendorstEitrichKlessetal.2007,
  author    = {Grotendorst, Johannes and Eitrich, T. and Kless, A. and Druska, C.},
  title     = {Classification of Highly Unbalanced CYP450 Data of Drugs Using Cost Sensitive Machine Learning Techniques / Eitrich, T. ; Kless, A. ; Druska, C. ; Meyer, W. ; Grotendorst J.},
  series = {Journal of Chemical Information and Modeling. 47 (2007), H. 1},
  journal   = {Journal of Chemical Information and Modeling. 47 (2007), H. 1},
  isbn      = {1549-9596},
  pages     = {92 -- 103},
  year      = {2007},
  language  = {en}
}
@article{StulpeBuschHellwig1993,
  author    = {Stulpe, Werner and Busch, P. and Hellwig, K.-E.},
  title     = {Classical Representations of Finite-Dimensional Quantum Mechanics. Busch, P.; Hellwig, K.-E.; Stulpe, W.},
  series = {International Journal of Theoretical Physics. 32 (1993), H. 3},
  journal   = {International Journal of Theoretical Physics. 32 (1993), H. 3},
  isbn      = {1572-9575},
  pages     = {399 -- 405},
  year      = {1993},
  language  = {en}
}
@article{WollbrinkMasloZimmeretal.2020,
  author    = {Wollbrink, Moritz and Maslo, Semir and Zimmer, Daniel and Abbas, Karim and Arntz, Kristian and Bergs, Thomas},
  title     = {Clamping and substrate plate system for continuous additive build-up and post-processing of metal parts},
  series = {Procedia CIRP},
  volume    = {93},
  journal   = {Procedia CIRP},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {2212-8271},
  doi       = {10.1016/j.procir.2020.04.015},
  pages     = {108 -- 113},
  year      = {2020},
  abstract  = {The manufacturing share of laser powder bed fusion (L-PBF) increases in industrial application, but still many process steps are manually operated. Additionally, it is not possible to achieve tight dimensional tolerances or low surfaces roughness. Hence, a process chain has to be set up to combine additive manufacturing (AM) with further machining technologies. To achieve a continuous workpiece flow as basis for further industrialization of L-PBF, the paper presents a novel substrate system and its application on L-PBF machines and post-processing. The substrate system consists of a zero-point clamping system and a matrix-like interface of contact pins to be substantially connected to the workpiece within the L-PBF process.},
  language  = {en}
}
@article{ArtmannBurnsCanavesetal.2004,
  author    = {Artmann, Gerhard and Burns, Laura and Canaves, Jaume M. and Temiz Artmann, Ayseg{\"u}l},
  title     = {Circular dichroism spectra of human hemoglobin reveal a reversible structural transition at body temperature},
  series = {European Biophysics Journal. 33 (2004), H. 6},
  journal   = {European Biophysics Journal. 33 (2004), H. 6},
  isbn      = {1432-1017},
  pages     = {490 -- 496},
  year      = {2004},
  language  = {en}
}
@article{SchoeningBrinkmannDemuthetal.2004,
  author    = {Sch{\"o}ning, Michael Josef and Brinkmann, D. and Demuth, C. and Poghossian, Arshak},
  title     = {CIP (cleaning-in-place)-suitable „non-glass" pH sensor based on a Ta2O5-gate EIS structure},
  series = {Digest of technical papers : September 12 - 15, 2004, Rome, Italy, Pontificia Universitas Sancto Thoma Aquinate in Urbe / [conference chairperson: C. Di Natale].},
  journal   = {Digest of technical papers : September 12 - 15, 2004, Rome, Italy, Pontificia Universitas Sancto Thoma Aquinate in Urbe / [conference chairperson: C. Di Natale].},
  address   = {Roma},
  isbn      = {88-7621-282-5},
  pages     = {857 -- 860},
  year      = {2004},
  language  = {en}
}
@article{SchoeningBrinkmannRolkaetal.2005,
  author    = {Sch{\"o}ning, Michael Josef and Brinkmann, D. and Rolka, David and Demuth, C. and Poghossian, Arshak},
  title     = {CIP (cleaning-in-place) suitable "non-glass" pH sensor based on a Ta2O5-gate EIS structure},
  series = {Sensors and Actuators B: Chemical. 111-112 (2005)},
  journal   = {Sensors and Actuators B: Chemical. 111-112 (2005)},
  isbn      = {0925-4005},
  pages     = {423 -- 429},
  year      = {2005},
  language  = {en}
}