@article{AkimbekovDigelSherelkhanetal.2020,
  author    = {Akimbekov, Nuraly S. and Digel, Ilya and Sherelkhan, Dinara K. and Lutfor, Afzalunnessa B. and Razzaque, Mohammed S.},
  title     = {Vitamin D and the Host-Gut Microbiome: A Brief Overview},
  series = {Acta Histochemica et Cytochemica},
  volume    = {53},
  journal   = {Acta Histochemica et Cytochemica},
  number    = {3},
  publisher = {Japan Society of Histochemistry and Cytochemistry},
  address   = {Osaka},
  issn      = {1347-5800},
  doi       = {10.1267/ahc.20011},
  pages     = {33 -- 42},
  year      = {2020},
  abstract  = {There is a growing body of evidence for the effects of vitamin D on intestinal host-microbiome interactions related to gut dysbiosis and bowel inflammation. This brief review highlights the potential links between vitamin D and gut health, emphasizing the role of vitamin D in microbiological and immunological mechanisms of inflammatory bowel diseases. A comprehensive literature search was carried out in PubMed and Google Scholar using combinations of keywords "vitamin D," "intestines," "gut microflora," "bowel inflammation". Only articles published in English and related to the study topic are included in the review. We discuss how vitamin D (a) modulates intestinal microbiome function, (b) controls antimicrobial peptide expression, and (c) has a protective effect on epithelial barriers in the gut mucosa. Vitamin D and its nuclear receptor (VDR) regulate intestinal barrier integrity, and control innate and adaptive immunity in the gut. Metabolites from the gut microbiota may also regulate expression of VDR, while vitamin D may influence the gut microbiota and exert anti-inflammatory and immune-modulating effects. The underlying mechanism of vitamin D in the pathogenesis of bowel diseases is not fully understood, but maintaining an optimal vitamin D status appears to be beneficial for gut health. Future studies will shed light on the molecular mechanisms through which vitamin D and VDR interactions affect intestinal mucosal immunity, pathogen invasion, symbiont colonization, and antimicrobial peptide expression.},
  language  = {en}
}
@incollection{AkimbekovDigelSherelkhanetal.2022,
  author    = {Akimbekov, Nuraly S. and Digel, Ilya and Sherelkhan, Dinara K. and Razzaque, Mohammed S.},
  title     = {Vitamin D and Phosphate Interactions in Health and Disease},
  series = {Phosphate Metabolism},
  booktitle = {Phosphate Metabolism},
  publisher = {Springer},
  address   = {Cham},
  isbn      = {978-3-030-91621-3},
  doi       = {10.1007/978-3-030-91623-7_5},
  pages     = {37 -- 46},
  year      = {2022},
  abstract  = {Vitamin D plays an essential role in calcium and inorganic phosphate (Pi) homeostasis, maintaining their optimal levels to assure adequate bone mineralization. Vitamin D, as calcitriol (1,25(OH)2D), not only increases intestinal calcium and phosphate absorption but also facilitates their renal reabsorption, leading to elevated serum calcium and phosphate levels. The interaction of 1,25(OH)2D with its receptor (VDR) increases the efficiency of intestinal absorption of calcium to 30-40\% and phosphate to nearly 80\%. Serum phosphate levels can also influence 1,25 (OH)2D and fibroblast growth factor 23 (FGF23) levels, i.e., higher phosphate concentrations suppress vitamin D activation and stimulate parathyroid hormone (PTH) release, while a high FGF23 serum level leads to reduced vitamin D synthesis. In the vitamin D-deficient state, the intestinal calcium absorption decreases and the secretion of PTH increases, which in turn causes the stimulation of 1,25(OH)2D production, resulting in excessive urinary phosphate loss. Maintenance of phosphate homeostasis is essential as hyperphosphatemia is a risk factor of cardiovascular calcification, chronic kidney diseases (CKD), and premature aging, while hypophosphatemia is usually associated with rickets and osteomalacia. This chapter elaborates on the possible interactions between vitamin D and phosphate in health and disease.},
  language  = {en}
}
@book{DigelZhubanovaAkimbekov2012,
  author    = {Digel, Ilya and Zhubanova, Azhar Ahmetovna and Akimbekov, Nuraly Shardarbekovich},
  title     = {Visual Virology},
  address   = {Almaty},
  isbn      = {978-601-247-298-1},
  pages     = {144 S. : zahlr. Ill.},
  year      = {2012},
  language  = {en}
}
@techreport{DigelKayser2017,
  author    = {Digel, Ilya and Kayser, Peter},
  title     = {VirEx - Eliminierung von Quarant{\"a}ne relevanten Viroiden aus Kulturpflanzen Abschlussbericht des Projektes KMU-innovativ-12: Teilprojekt 3},
  publisher = {Institut f{\"u}r Bioengineering (IfB) der FH Aachen},
  address   = {Aachen},
  doi       = {10.2314/GBV:1012136345},
  year      = {2017},
  language  = {de}
}
@inproceedings{AzarDigel2019,
  author    = {Azar, Fouad and Digel, Ilya},
  title     = {Utilization of fluorescence spectroscopy and neural networks in clinical analysis},
  series = {3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH Aachen},
  booktitle = {3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH Aachen},
  editor    = {Staat, Manfred and Erni, Daniel},
  publisher = {Universit{\"a}t Duisburg-Essen},
  address   = {Duisburg},
  organization    = {MedTech Symposium},
  isbn      = {978-3-940402-22-6},
  doi       = {10.17185/duepublico/48750},
  pages     = {40 -- 41},
  year      = {2019},
  abstract  = {Fluorescence topography of human urine in combination with learning algorithms can provide a variant pattern recognition method in analytical clinical chemistry and, eventually, diagnosis.},
  language  = {en}
}
@article{AkimbekovZhubanovaMansurovetal.2010,
  author    = {Akimbekov, N. Sh. and Zhubanova, A. A. and Mansurov, Z. A. and Digel, Ilya and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l},
  title     = {Use of Carbonized Rise Shell for the local treatment of wounds},
  series = {Eurasian ChemTech Journal},
  volume    = {12},
  journal   = {Eurasian ChemTech Journal},
  number    = {2},
  publisher = {Institute of Combustion Problems},
  address   = {Almaty},
  issn      = {2522-4867},
  doi       = {10.18321/ectj35},
  pages     = {133 -- 138},
  year      = {2010},
  abstract  = {On the model of musculocutaneous wound in rats, the effect of applicative sorption by carbonized rise shell (CRS) on the healing of festering wound was studied. It has been shown, that cytological changes end with rapid scar formation. The use of CRS at the period of severe purulent wound contributes to its favorable course, prevents the development of complications of the animals from sepsis.},
  language  = {en}
}
@incollection{ZhubanovaMansurovDigel2020,
  author    = {Zhubanova, Azhar A. and Mansurov, Zulkhair A. and Digel, Ilya},
  title     = {Use of Advanced Nanomaterials for Bioremediation of Contaminated Ecosystems},
  series = {Carbon Nanomaterials in Biomedicine and the Environment},
  booktitle = {Carbon Nanomaterials in Biomedicine and the Environment},
  publisher = {Jenny Stanford Publishing},
  address   = {Singapore},
  isbn      = {978-981-4800-27-3},
  doi       = {10.1201/9780429428647-18},
  pages     = {353 -- 378},
  year      = {2020},
  abstract  = {This chapter shows that nanomaterials obtained by high-temperature carbonization of inexpensive plant raw material such as rice husk, grape seeds, and walnut shells can serve as a basis for the production of highly efficient microbial drugs, biodestructors, biosorbents, and biocatalysts, which are promising for the remediation of the ecosystem contaminated with heavy and radioactive metals, oil and oil products. A strong interest in engineering zymology is dictated by the necessity to address the issues of monitoring enzymatic processes, treatment, and diagnosis of a number of common human diseases, environmental pollution, quality control of pharmaceuticals and food. Nanomaterials obtained by high-temperature carbonization of cheap plant raw material such as-rice husks, grape seeds and walnut shells, can serve as a basis for creating of highly effective microbial preparations-biodestructors, biosorbents and biocatalysts, which are promising for the use of contaminated ecosystems, and for restoration of human intestine microecology.},
  language  = {en}
}
@article{DigelAkimbekovTuralievaetal.2013,
  author    = {Digel, Ilya and Akimbekov, N. and Turalieva, M. and Mansurov, Z. and Temiz Artmann, Ayseg{\"u}l and Eshibaev, A. and Zhubanova, A.},
  title     = {Usage of Carbonized Plant Wastes for Purification of Aqueous Solutions},
  series = {Journal of Industrial Technology and Engineering},
  volume    = {2},
  journal   = {Journal of Industrial Technology and Engineering},
  number    = {07},
  pages     = {47 -- 54},
  year      = {2013},
  language  = {en}
}
@article{StadlerGarveyBocahutetal.2012,
  author    = {Stadler, Andreas M. and Garvey, G. J. and Bocahut, A. and Sacquin-Mora, S. and Digel, Ilya and Schneider, G. J. and Natali, F. and Artmann, Gerhard and Zaccai, G.},
  title     = {Thermal fluctuations of haemoglobin from different species : adaptation to temperature via conformational dynamics},
  series = {Journal of the Royal Society Interface},
  volume    = {9},
  journal   = {Journal of the Royal Society Interface},
  number    = {76},
  publisher = {The Royal Society},
  address   = {London},
  issn      = {1742-5689},
  doi       = {10.1098/rsif.2012.0364},
  pages     = {2845 -- 2855},
  year      = {2012},
  abstract  = {Thermodynamic stability, configurational motions and internal forces of haemoglobin (Hb) of three endotherms (platypus, Ornithorhynchus anatinus; domestic chicken, Gallus gallus domesticus and human, Homo sapiens) and an ectotherm (salt water crocodile, Crocodylus porosus) were investigated using circular dichroism, incoherent elastic neutron scattering and coarse-grained Brownian dynamics simulations. The experimental results from Hb solutions revealed a direct correlation between protein resilience, melting temperature and average body temperature of the different species on the 0.1 ns time scale. Molecular forces appeared to be adapted to permit conformational fluctuations with a root mean square displacement close to 1.2 {\AA} at the corresponding average body temperature of the endotherms. Strong forces within crocodile Hb maintain the amplitudes of motion within a narrow limit over the entire temperature range in which the animal lives. In fully hydrated powder samples of human and chicken, Hb mean square displacements and effective force constants on the 1 ns time scale showed no differences over the whole temperature range from 10 to 300 K, in contrast to the solution case. A complementary result of the study, therefore, is that one hydration layer is not sufficient to activate all conformational fluctuations of Hb in the pico- to nanosecond time scale which might be relevant for biological function. Coarse-grained Brownian dynamics simulations permitted to explore residue-specific effects. They indicated that temperature sensing of human and chicken Hb occurs mainly at residues lining internal cavities in the β-subunits.},
  language  = {en}
}
@article{DigelZhubanovaNojimaetal.2004,
  author    = {Digel, Ilya and Zhubanova, Azhar A. and Nojima, H. and Artmann, Gerhard},
  title     = {The use of bactericidal effects of cluster ions generated by plasma in medical biotechnology},
  series = {Biotechnologija : teorija i praktika (2004)},
  journal   = {Biotechnologija : teorija i praktika (2004)},
  isbn      = {1028-9399},
  pages     = {46 -- 52},
  year      = {2004},
  language  = {en}
}