@article{MuribTranCeunincketal.2012, author = {Murib, Mohammed S. and Tran, Anh Quang and Ceuninck, Ward de and Sch{\"o}ning, Michael Josef and Nesladek, Milos and Serpeng{\"u}zel, Ali and Wagner, Patrick}, title = {Analysis of an optical biosensor based on elastic light scattering from diamond-, glass-, and sapphire microspheres}, series = {Physica Status Solidi A}, volume = {209}, journal = {Physica Status Solidi A}, number = {9}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.201100795}, pages = {1804 -- 1810}, year = {2012}, abstract = {Deoxyribonucleic acid (DNA) and protein recognition are now standard tools in biology. In addition, the special optical properties of microsphere resonators expressed by the high quality factor (Q-factor) of whispering gallery modes (WGMs) or morphology dependent resonances (MDRs) have attracted the attention of the biophotonic community. Microsphere-based biosensors are considered as powerful candidates to achieve label-free recognition of single molecules due to the high sensitivity of their WGMs. When the microsphere surface is modified with biomolecules, the effective refractive index and the effective size of the microsphere change resulting in a resonant wavelength shift. The transverse electric (TE) and the transverse magnetic (TM) elastic light scattering intensity of electromagnetic waves at 600 and 1400 nm are numerically calculated for DNA and unspecific binding of proteins to the microsphere surface. The effect of changing the optical properties was studied for diamond (refractive index 2.34), glass (refractive index 1.50), and sapphire (refractive index 1.75) microspheres with a 50 µm radius. The mode spacing, the linewidth of WGMs, and the shift of resonant wavelength due to the change in radius and refractive index, were analyzed by numerical simulations. Preliminary results of unspecific binding of biomolecules are presented. The calculated shift in WGMs can be used for biomolecules detection.}, language = {en} } @article{PoghossianSchoeningSchrothetal.2001, author = {Poghossian, Arshak and Sch{\"o}ning, Michael Josef and Schroth, P. and Simonis, A. and L{\"u}th, H.}, title = {An ISFET-based penicillin sensor with high sensitivity, low detection limit and long lifetime}, series = {Sensors and Actuators B. 76 (2001), H. 1-3}, journal = {Sensors and Actuators B. 76 (2001), H. 1-3}, isbn = {0925-4005}, pages = {519 -- 526}, year = {2001}, language = {en} } @article{SchuetzSchoeningSchrothetal.2000, author = {Sch{\"u}tz, S. and Sch{\"o}ning, Michael Josef and Schroth, P. and Weißbecker, B. and Kordos, P. and L{\"u}th, H. and Hummel, Hans E.}, title = {An insectbased BioFET as a bioelectronic nose}, series = {Sensors and Actuators B. 65 (2000), H. 1-3}, journal = {Sensors and Actuators B. 65 (2000), H. 1-3}, isbn = {0925-4005}, pages = {291 -- 295}, year = {2000}, language = {en} } @article{SchuetzSchoeningSchrothetal.1998, author = {Sch{\"u}tz, S. and Sch{\"o}ning, Michael Josef and Schroth, P. and Weißbecker, B. and Kordos, P. and L{\"u}th, H. and Hummel, Hans E.}, title = {An insectbased BioFET as a bioelectronic nose}, series = {Proceedings of the Seventh International Meeting on Chemical Sensors : 27 - 30 July, 1998, Beijing, P. R. China / ed. Zhi-Gang Zhou}, journal = {Proceedings of the Seventh International Meeting on Chemical Sensors : 27 - 30 July, 1998, Beijing, P. R. China / ed. Zhi-Gang Zhou}, publisher = {Elsevier}, address = {Amsterdam [u.a.]}, pages = {314 -- 316}, year = {1998}, language = {en} } @article{HonarvarfardGamellaPoghossianetal.2017, author = {Honarvarfard, Elham and Gamella, Maria and Poghossian, Arshak and Sch{\"o}ning, Michael Josef and Katz, Evgeny}, title = {An enzyme-based reversible Controlled NOT (CNOT) logic gate operating on a semiconductor transducer}, series = {Applied Materials Today}, volume = {9}, journal = {Applied Materials Today}, publisher = {Elsevier}, address = {Amsterdam}, issn = {2352-9407}, doi = {10.1016/j.apmt.2017.08.003}, pages = {266 -- 270}, year = {2017}, abstract = {An enzyme-based biocatalytic system mimicking operation of a logically reversible Controlled NOT (CNOT) gate has been interfaced with semiconductor electronic transducers. Electrolyte-insulator-semiconductor (EIS) structures have been used to transduce chemical changes produced by the enzyme system to an electronically readable capacitive output signal using field-effect features of the EIS device. Two enzymes, urease and esterase, were immobilized on the insulating interface of EIS structure producing local pH changes performing XOR logic operation controlled by various combinations of the input signals represented by urea and ethyl butyrate. Another EIS transducer was functionalized with esterase only, thus performing Identity (ID) logic operation for the ethyl butyrate input. Both semiconductor devices assembled in parallel operated as a logically reversible CNOT gate. The present system, despite its simplicity, demonstrated for the first time logically reversible function of the enzyme system transduced electronically with the semiconductor devices. The biomolecular realization of a CNOT gate interfaced with semiconductors is promising for integration into complex biomolecular networks and future biosensor/biomedical applications.}, language = {en} } @article{MoseleyHalamekKrameretal.2014, author = {Moseley, Fiona and Halamek, Jan and Kramer, Friederike and Poghossian, Arshak and Sch{\"o}ning, Michael Josef and Katz, Evgeny}, title = {An enzyme-based reversible CNOT logic gate realized in a flow system}, series = {Analyst}, volume = {139}, journal = {Analyst}, number = {8}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, issn = {1364-5528 (E-Journal) ; 0003-2654 (Print)}, doi = {10.1039/C4AN00133H}, pages = {1839 -- 1842}, year = {2014}, abstract = {An enzyme system organized in a flow device was used to mimic a reversible Controlled NOT (CNOT) gate with two input and two output signals. Reversible conversion of NAD⁺ and NADH cofactors was used to perform a XOR logic operation, while biocatalytic hydrolysis of p-nitrophenyl phosphate resulted in an Identity operation working in parallel. The first biomolecular realization of a CNOT gate is promising for integration into complex biomolecular networks and future biosensor/biomedical applications.}, language = {en} } @article{AbouzarPoghossianPedrazaetal.2011, author = {Abouzar, Maryam H. and Poghossian, Arshak and Pedraza, A. M. and Gandhi, D. and Ingebrandt, S. and Moritz, W. and Sch{\"o}ning, Michael Josef}, title = {An array of field-effect nanoplate SOI capacitors for (bio-)chemical sensing}, series = {Biosensors and Bioelectronics. 26 (2011), H. 6}, journal = {Biosensors and Bioelectronics. 26 (2011), H. 6}, publisher = {Elsevier}, address = {Amsterdam}, isbn = {0956-5663}, pages = {3023 -- 3028}, year = {2011}, language = {en} } @article{SchusserPoghossianBaeckeretal.2015, author = {Schusser, Sebastian and Poghossian, Arshak and B{\"a}cker, Matthias and Krischer, M. and Leinhos, Marcel and Wagner, P. and Sch{\"o}ning, Michael Josef}, title = {An application of field-effect sensors for in-situ monitoring of degradation of biopolymers}, series = {Sensors and actuators B: Chemical}, volume = {207, Part B}, journal = {Sensors and actuators B: Chemical}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1873-3077 (E-Journal); 0925-4005 (Print)}, doi = {10.1016/j.snb.2014.10.058}, pages = {954 -- 959}, year = {2015}, abstract = {The characterization of the degradation kinetics of biodegradable polymers is mandatory with regard to their proper application. In the present work, polymer-modified electrolyte-insulator-semiconductor (PMEIS) field-effect sensors have been applied for in-situ monitoring of the pH-dependent degradation kinetics of the commercially available biopolymer poly(d,l-lactic acid) (PDLLA) in buffer solutions from pH 3 to pH 13. PDLLA films of 500 nm thickness were deposited on the surface of an Al-p-Si-SiO2-Ta2O5 structure from a polymer solution by means of spin-coating method. The PMEIS sensor is, in principle, capable to detect any changes in bulk, surface and interface properties of the polymer induced by degradation processes. A faster degradation has been observed for PDLLA films exposed to alkaline solutions (pH 9, pH 11 and pH 13).}, language = {en} } @inproceedings{WuPoghossianWerneretal.2013, author = {Wu, Chunsheng and Poghossian, Arshak and Werner, Frederik and Bronder, Thomas and B{\"a}cker, Matthias and Wang, Ping and Sch{\"o}ning, Michael Josef}, title = {An application of a scanning light-addressable potentiometric sensor for label-free DNA detection}, series = {11. Dresdner Sensor-Symposium : 9.-11.12.2013}, booktitle = {11. Dresdner Sensor-Symposium : 9.-11.12.2013}, organization = {Dresdner Sensor-Symposium <11, 2013>}, isbn = {978-3-9813484-5-3}, pages = {164 -- 168}, year = {2013}, language = {en} } @article{SchoeningJacobsMucketal.2005, author = {Sch{\"o}ning, Michael Josef and Jacobs, M. and Muck, A. and Knobbe, D.-T. and Wang, J. and Chatrathi, M. and Spillmann, S.}, title = {Amperometric PDMS/glass capillary electrophoresis-based biosensor microchip for catechol and dopamin detection}, series = {Sensors and Actuators B. 108 (2005), H. 1-2}, journal = {Sensors and Actuators B. 108 (2005), H. 1-2}, isbn = {0925-4005}, pages = {688 -- 694}, year = {2005}, language = {en} }