@article{MaezawaFoerster2003, author = {Maezawa, Koichi and F{\"o}rster, Arnold}, title = {Quantum transport devices based on resonant tunneling}, series = {Nanoelectronics and information technology : advanced electronic materials and novel devices / Rainer Waser (ed.).}, journal = {Nanoelectronics and information technology : advanced electronic materials and novel devices / Rainer Waser (ed.).}, publisher = {Wiley-VCH}, address = {Weinheim}, isbn = {3-527-40363-9}, pages = {407 -- 424}, year = {2003}, language = {en} } @article{DantismRoehlenSelmeretal.2019, author = {Dantism, Shahriar and R{\"o}hlen, Desiree and Selmer, Thorsten and Wagner, Torsten and Wagner, Patrick and Sch{\"o}ning, Michael Josef}, title = {Quantitative differential monitoring of the metabolic activity of Corynebacterium glutamicum cultures utilizing a light-addressable potentiometric sensor system}, series = {Biosensors and Bioelectronics}, volume = {139}, journal = {Biosensors and Bioelectronics}, publisher = {Elsevier}, address = {Amsterdam}, doi = {10.1016/j.bios.2019.111332}, pages = {Artikel 111332}, year = {2019}, language = {en} } @article{KloockMourzinaSchubertetal.2004, author = {Kloock, Joachim P. and Mourzina, Y. and Schubert, J. and Ermelenko, Y. and Sch{\"o}ning, Michael Josef}, title = {Pulsed laser deposition: A tool for fabricating thin-film microsensors}, series = {Biomedizinische Technik. 49 (2004), H. 2}, journal = {Biomedizinische Technik. 49 (2004), H. 2}, isbn = {0932-4666}, pages = {1032 -- 1033}, year = {2004}, language = {en} } @article{SchoeningMourzinaSchubertetal.2001, author = {Sch{\"o}ning, Michael Josef and Mourzina, Yu.G. and Schubert, J. and Zander, W. and Legin, A. and Vlasov, Y. G. and L{\"u}th, H.}, title = {Pulsed laser deposition - an innovative technique for preparing inorganic thin films}, series = {Electroanalysis. 13 (2001), H. 8-9}, journal = {Electroanalysis. 13 (2001), H. 8-9}, isbn = {1040-0397}, pages = {727 -- 732}, year = {2001}, language = {en} } @inproceedings{PlatenPoghossianSchoening2006, author = {Platen, J. and Poghossian, Arshak and Sch{\"o}ning, Michael Josef}, title = {Pr{\"a}paration von selbstjustierenden Nanostrukturen mittels Schichtausdehnungstechnik}, series = {Sensoren und Mess-Systeme 2006 : Vortr{\"a}ge der 13. ITG/GMA-Fachtagung vom 13. bis 14.3.2006 in Freiburg/Breisgau}, booktitle = {Sensoren und Mess-Systeme 2006 : Vortr{\"a}ge der 13. ITG/GMA-Fachtagung vom 13. bis 14.3.2006 in Freiburg/Breisgau}, publisher = {VDE Verl.}, address = {Berlin}, isbn = {3-8007-2939-3}, pages = {277 -- 280}, year = {2006}, language = {de} } @article{EngelmannPourshahidiShalabyetal.2022, author = {Engelmann, Ulrich M. and Pourshahidi, Mohammad Ali and Shalaby, Ahmed and Krause, Hans-Joachim}, title = {Probing particle size dependency of frequency mixing magnetic detection with dynamic relaxation simulation}, series = {Journal of Magnetism and Magnetic Materials}, volume = {563}, journal = {Journal of Magnetism and Magnetic Materials}, number = {In progress, Art. No. 169965}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0304-8853}, doi = {10.1016/j.jmmm.2022.169965}, year = {2022}, abstract = {Biomedical applications of magnetic nanoparticles (MNP) fundamentally rely on the particles' magnetic relaxation as a response to an alternating magnetic field. The magnetic relaxation complexly depends on the interplay of MNP magnetic and physical properties with the applied field parameters. It is commonly accepted that particle core size is a major contributor to signal generation in all the above applications, however, most MNP samples comprise broad distribution spanning nm and more. Therefore, precise knowledge of the exact contribution of individual core sizes to signal generation is desired for optimal MNP design generally for each application. Specifically, we present a magnetic relaxation simulation-driven analysis of experimental frequency mixing magnetic detection (FMMD) for biosensing to quantify the contributions of individual core size fractions towards signal generation. Applying our method to two different experimental MNP systems, we found the most dominant contributions from approx. 20 nm sized particles in the two independent MNP systems. Additional comparison between freely suspended and immobilized MNP also reveals insight in the MNP microstructure, allowing to use FMMD for MNP characterization, as well as to further fine-tune its applicability in biosensing.}, language = {en} } @article{HenkenOosterhuisOehlschlaegeretal.2012, author = {Henken, F. E. and Oosterhuis, K. and {\"O}hlschl{\"a}ger, Peter and Bosch, L. and Hooijberg, E. and Haanen, J. B. A. G. and Steenbergen, R. D. M.}, title = {Preclinical safety evaluation of DNA vaccines encoding modified HPV16 E6 and E7}, series = {Vaccine}, volume = {30}, journal = {Vaccine}, number = {28}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0264-410X}, doi = {10.1016/j.vaccine.2012.04.013}, pages = {4259 -- 4266}, year = {2012}, abstract = {Persistent infection with high-risk human papillomaviruses (hrHPV) can result in the formation of anogenital cancers. As hrHPV proteins E6 and E7 are required for cancer initiation and maintenance, they are ideal targets for immunotherapeutic interventions. Previously, we have described the development of DNA vaccines for the induction of HPV16 E6 and E7 specific T cell immunity. These vaccines consist of 'gene-shuffled' (SH) versions of HPV16 E6 and E7 that were fused to Tetanus Toxin Fragment C domain 1 (TTFC) and were named TTFC-E6SH and TTFC-E7SH. Gene-shuffling was performed to avoid the risk of inducing malignant transformation at the vaccination site. Here, we describe the preclinical safety evaluation of these candidate vaccines by analysis of their transforming capacity in vitro using established murine fibroblasts (NIH 3T3 cells) and primary human foreskin keratinocytes (HFKs). We demonstrate that neither ectopic expression of TTFC-E6SH and TTFC-E7SH alone or in combination enabled NIH 3T3 cells to form colonies in soft agar. In contrast, expression of HPV16 E6WT and E7WT alone or in combination resulted in effective transformation. Similarly, retroviral transduction of HFKs from three independent donors with both TTFC-E6SH and TTFC-E7SH alone or in combination did not show any signs of immortalization. In contrast, the combined expression of E6WT and E7WT induced immortalization in HFKs from all donors. Based on these results we consider it justified to proceed to clinical evaluation of DNA vaccines encoding TTFC-E6SH and TTFC-E7SH in patients with HPV16 associated (pre)malignancies.}, language = {en} } @article{YoshinobuUiIwasakietal.2004, author = {Yoshinobu, T. and Ui, Y. and Iwasaki, H. and N{\"a}ther, Niko and Koudelka-Hep, M. and Sch{\"o}ning, Michael Josef}, title = {Potentiometric imaging in a microfluidic channel}, series = {Biomedizinische Technik. 49 (2004), H. 2}, journal = {Biomedizinische Technik. 49 (2004), H. 2}, isbn = {0932-4666}, pages = {998 -- 999}, year = {2004}, language = {en} } @article{PoghossianCherstvyIngebrandtetal.2005, author = {Poghossian, Arshak and Cherstvy, A. and Ingebrandt, S. and Offenh{\"a}usser, A. and Sch{\"o}ning, Michael Josef}, title = {Possibilities and limitations of label-free detection of DNA hybridization with field-effect-based devices}, series = {Sensors and Actuators B. 111-112 (2005)}, journal = {Sensors and Actuators B. 111-112 (2005)}, isbn = {0925-4005}, pages = {470 -- 480}, year = {2005}, language = {en} } @article{PoghossianCherstvySchoening2004, author = {Poghossian, Arshak and Cherstvy, A. and Sch{\"o}ning, Michael Josef}, title = {Possibilities and limitations of label-free detection of DNA hybridization with field-effect based devices}, series = {Digest of technical papers : September 12 - 15, 2004, Rome, Italy, Pontificia Universitas Sancto Thoma Aquinate in Urbe / [conference chairperson: C. Di Natale].}, journal = {Digest of technical papers : September 12 - 15, 2004, Rome, Italy, Pontificia Universitas Sancto Thoma Aquinate in Urbe / [conference chairperson: C. Di Natale].}, address = {Roma}, isbn = {88-7621-282-5}, pages = {173 -- 176}, year = {2004}, language = {en} }