@incollection{AkimbekovDigelSherelkhanetal.2022,
  author    = {Akimbekov, Nuraly S. and Digel, Ilya and Sherelkhan, Dinara K. and Razzaque, Mohammed S.},
  title     = {Vitamin D and Phosphate Interactions in Health and Disease},
  series = {Phosphate Metabolism},
  booktitle = {Phosphate Metabolism},
  publisher = {Springer},
  address   = {Cham},
  isbn      = {978-3-030-91621-3},
  doi       = {10.1007/978-3-030-91623-7_5},
  pages     = {37 -- 46},
  year      = {2022},
  abstract  = {Vitamin D plays an essential role in calcium and inorganic phosphate (Pi) homeostasis, maintaining their optimal levels to assure adequate bone mineralization. Vitamin D, as calcitriol (1,25(OH)2D), not only increases intestinal calcium and phosphate absorption but also facilitates their renal reabsorption, leading to elevated serum calcium and phosphate levels. The interaction of 1,25(OH)2D with its receptor (VDR) increases the efficiency of intestinal absorption of calcium to 30-40\% and phosphate to nearly 80\%. Serum phosphate levels can also influence 1,25 (OH)2D and fibroblast growth factor 23 (FGF23) levels, i.e., higher phosphate concentrations suppress vitamin D activation and stimulate parathyroid hormone (PTH) release, while a high FGF23 serum level leads to reduced vitamin D synthesis. In the vitamin D-deficient state, the intestinal calcium absorption decreases and the secretion of PTH increases, which in turn causes the stimulation of 1,25(OH)2D production, resulting in excessive urinary phosphate loss. Maintenance of phosphate homeostasis is essential as hyperphosphatemia is a risk factor of cardiovascular calcification, chronic kidney diseases (CKD), and premature aging, while hypophosphatemia is usually associated with rickets and osteomalacia. This chapter elaborates on the possible interactions between vitamin D and phosphate in health and disease.},
  language  = {en}
}
@masterthesis{Cekic2022,
  type      = {Bachelor Thesis},
  author    = {Cekic, Dilara},
  title     = {Visionsbild eines BMW AG internen Tools : Optimierung einer datenzentrierten Plattform der BMW AG},
  publisher = {FH Aachen},
  address   = {Aachen},
  year      = {2022},
  abstract  = {Die BMW AG verfolgt mehrere Ans{\"a}tze eine optimierte Effizienzsteigerung durch eigens entwickelte Softwaretools zu erreichen. Der Fokus hierbei liegt in der Erm{\"o}glichung einer datenzentrierten, nutzerorientierten und hochautomatisierten Fahrzeugentwicklung. Das eigen von der BMW AG entwickelte Software-Tool „Parts List" dient als digitale Bauteilliste f{\"u}r Entwicklungsteams. Das Tool b{\"u}ndelt mehrere Datenbanken und stellt diese in Echtzeit zur Verf{\"u}gung. Somit kann der manuelle Pflegeaufwand erheblich reduziert und eine Durchg{\"a}ngigkeit einer Vielzahl von Daten erm{\"o}glicht werden. Der Fokus der Abschlussarbeit liegt in der konzeptionellen und gestalterischen Optimierung des Tools. Dabei wird insbesondere der User Centered Design Prozess betrachtet, bei dem die Nutzer bzw. die Entwicklungsteams im Zentrum stehen.},
  language  = {de}
}
@article{BhattaraiHorbachStaatetal.2022,
  author    = {Bhattarai, Aroj and Horbach, Andreas and Staat, Manfred and Kowalczyk, Wojciech and Tran, Thanh Ngoc},
  title     = {Virgin passive colon biomechanics and a literature review of active contraction constitutive models},
  series = {Biomechanics},
  volume    = {2},
  journal   = {Biomechanics},
  number    = {2},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2673-7078},
  doi       = {10.3390/biomechanics2020013},
  pages     = {138 -- 157},
  year      = {2022},
  abstract  = {The objective of this paper is to present our findings on the biomechanical aspects of the virgin passive anisotropic hyperelasticity of the porcine colon based on equibiaxial tensile experiments. Firstly, the characterization of the intestine tissues is discussed for a nearly incompressible hyperelastic fiber-reinforced Holzapfel-Gasser-Ogden constitutive model in virgin passive loading conditions. The stability of the evaluated material parameters is checked for the polyconvexity of the adopted strain energy function using positive eigenvalue constraints of the Hessian matrix with MATLAB. The constitutive material description of the intestine with two collagen fibers in the submucosal and muscular layer each has been implemented in the FORTRAN platform of the commercial finite element software LS-DYNA, and two equibiaxial tensile simulations are presented to validate the results with the optical strain images obtained from the experiments. Furthermore, this paper also reviews the existing models of the active smooth muscle cells, but these models have not been computationally studied here. The review part shows that the constitutive models originally developed for the active contraction of skeletal muscle based on Hill's three-element model, Murphy's four-state cross-bridge chemical kinetic model and Huxley's sliding-filament hypothesis, which are mainly used for arteries, are appropriate for numerical contraction numerical analysis of the large intestine.},
  language  = {en}
}
@masterthesis{Wetzlar2022,
  type      = {Bachelor Thesis},
  author    = {Wetzlar, Jana},
  title     = {Vielgut Festival 2022 : Etablierung eines neuen Musikfestivals in Aachen},
  publisher = {FH Aachen},
  address   = {Aachen},
  pages     = {45 Seiten},
  year      = {2022},
  abstract  = {Endlich! Nach {\"u}ber zwei Jahren kulturellen Stillstands richtet der Musiknetzwerk Aachen e.V. ein Festival aus. Die Bachelorandin Jana Wetzlar {\"u}bernimmt hierbei die Veranstaltungsplanung und -bewerbung. Der erste Teil der Arbeit umfasst die Erarbeitung eines einzigartigen Festivalkonzepts, bei dem die F{\"o}rderung von jungen Newcomerk{\"u}nstler:innen und die {\"o}kologische Nachhaltigkeit der Veranstaltung im Vordergrund stehen. Eine weitere Besonderheit stellt das parit{\"a}tisch besetzte K{\"u}nstler:innen-Line-Up dar. Im zweiten Teil der Arbeit wurden eine umfangreiche Werbekampagne sowie ein passendes Corporate Design entwickelt, die die Besonderheiten des Festivals hervorheben und viele Festivalbesucher:innen generieren sollen. Die {\"u}bergeordneten Ziele der Arbeit bestehen darin, einen Beitrag zur gesellschaftlichen Etablierung des Musiknetzwerk Aachen e.V. zu leisten und die Voraussetzungen f{\"u}r ein j{\"a}hrlich wiederkehrendes Festival zu schaffen.},
  language  = {de}
}
@article{KubalskiButenwegElDeib2022,
  author    = {Kubalski, Thomas and Butenweg, Christoph and El-Deib, Khaled},
  title     = {Vereinfachte Ber{\"u}cksichtigung der Rahmentragwirkung in Mauerwerksgeb{\"a}uden},
  series = {Bautechnik},
  volume    = {99},
  journal   = {Bautechnik},
  number    = {12},
  editor    = {Jesse, Dirk},
  publisher = {Ernst \& Sohn},
  address   = {Berlin},
  issn      = {0932-8351},
  doi       = {10.1002/bate.202200081},
  pages     = {865 -- 928},
  year      = {2022},
  abstract  = {Aufgrund der gestiegenen Anforderungen durch h{\"o}here Ein-wirkungen aus Wind und Erdbeben ist eine Verbesserung und Optimierung der Berechnungs- und Bemessungsans{\"a}tze f{\"u}r Mauerwerksbauten erforderlich. Eine bessere Ausnutzung der Tragwerksreserven ist durch die Ber{\"u}cksichtigung der Rah-mentragwirkung mit einer Aktivierung der Deckenscheiben in den Rechenmodellen m{\"o}glich, die in der Praxis aufgrund der Komplexit{\"a}t der Wand-Decken-Interaktion bislang nicht aus-genutzt wird. Im vorliegenden Aufsatz wird ein vereinfachter Ansatz auf Grundlage der mitwirkenden Plattenbreite von Schubw{\"a}nden aus Mauerwerk vorgestellt, der die wesentli-chen Einfl ussfaktoren in parametrisierten Tabellen erfasst. Damit steht den Tragwerksplanern ein einfach anwendbares Werkzeug zur Verf{\"u}gung, um die Rahmentragwirkung in der Mauerwerksbemessung anzusetzen.},
  language  = {de}
}
@article{KindmannKrausLaumannetal.2022,
  author    = {Kindmann, Rolf and Kraus, Matthias and Laumann, J{\"o}rg and Vette, Jan},
  title     = {Verallgemeinerte Berechnungsmethode f{\"u}r in Beton eingespannte Stahlprofile - Einspanntiefen, Tragf{\"a}higkeitsnachweise und Bemessungshilfen},
  series = {Stahlbau},
  volume    = {93},
  journal   = {Stahlbau},
  number    = {Early View},
  publisher = {Ernst \& Sohn GmbH},
  address   = {Berlin},
  issn      = {1437-1049},
  doi       = {10.1002/stab.202200024},
  pages     = {1 -- 25},
  year      = {2022},
  abstract  = {St{\"u}tzen und Tr{\"a}ger aus Stahlprofilen k{\"o}nnen in Fundamente oder W{\"a}nde aus Stahlbeton einbetoniert werden. Diese Anschl{\"u}sse wirken in der Regel wie Einspannungen, die eine ausreichende Einspanntiefe erfordern. Im Folgenden wird eine verallgemeinerte Berechnungsmethode f{\"u}r in Stahlbetonkonstruktionen eingespannte Stahlprofile aus gewalzten I-Profilen, geschweißten I-Profilen, runden Hohlprofilen, eckigen Hohlprofilen und einzelligen Kastenquerschnitten vorgestellt. F{\"u}r Beanspruchungen infolge einachsiger Biegung um die starke und schwache Profilachse werden der profilabh{\"a}ngige Ansatz der Betondruckspannungen im Einspannbereich und die Ermittlung der Einspanntiefe behandelt. Unter Ber{\"u}cksichtigung der Normalkraft werden an den maßgebenden Stellen Tragf{\"a}higkeitsnachweise f{\"u}r die Stahlprofile gef{\"u}hrt. Als Erg{\"a}nzung zu den Berechnungsformeln werden Bemessungshilfen zur Verf{\"u}gung gestellt, die die Wahl der mitwirkenden Breiten und der Einspanntiefen erleichtert.},
  language  = {de}
}
@misc{KrafftKukaUlberetal.2022,
  author    = {Krafft, Simone and Kuka, Katrin and Ulber, Roland and Tippk{\"o}tter, Nils},
  title     = {Utilization of Lolium perenne varieties as a renewable substrate for single-cell proteins, lactate, and composite materials},
  series = {Chemie Ingenieur Technik},
  volume    = {94},
  journal   = {Chemie Ingenieur Technik},
  number    = {9},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {0009-286X},
  doi       = {10.1002/cite.202255306},
  pages     = {1303 -- 1304},
  year      = {2022},
  abstract  = {Lolium perenne (perennial ryegrass) is aproductive and high-quality forage grass indigenous to Southern Europe, temperate Asia, and North Africa. Nowadays it is widespread and the dominant grass species on green areas in temperate climates. This abundant source of biomass is suitable for the development of bioeconomic processes because of its high cellulose and water-soluble carbohydrate content. In this work, novel breeds of the perennial ryegrass are being examined with regards to their quality parameters and biotechnological utilization options within the context of bioeconomy. Three processing operations are presented. In the first process, the perennial ryegrass is pretreated by pressing or hydrothermal extraction to derive glucosevia subsequent enzymatic hydrolysis of cellulose. A yield of up to 82 \% glucose was achieved when using the hydrothermal ex-traction as pretreatment. In a second process, the ryegrass is used to produce lactic acid in high concentrations. The influence of the growth conditions and the cutting time on the carboxylic acid yield is investigated. A yield of lactic acid of above 150 g kg⁻¹ dry matter was achieved. The third process is to use Lolium perenne as a substrate in the fermentation of K. marxianus for the microbial production of single-cell proteins. The perennial ryegrass is screw-pressed and the press juice is used as medium. When supplementing the press juice with yeast media components, a biomass concentration of up to 16 g L⁻¹ could be achieved.},
  language  = {en}
}
@misc{VarrialeKukaTippkoetteretal.2022,
  author    = {Varriale, Ludovica and Kuka, Katrin and Tippk{\"o}tter, Nils and Ulber, Roland},
  title     = {Use of a green biomass in a biorefinery platform},
  series = {Chemie Ingenieur Technik},
  volume    = {94},
  journal   = {Chemie Ingenieur Technik},
  number    = {9},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {0009-286X},
  doi       = {10.1002/cite.202255095},
  pages     = {1299},
  year      = {2022},
  abstract  = {The emerging environmental issues due to the use of fossil resources are encouraging the exploration of new renewable resources. Biomasses are attracting more interest due to the low environmental impacts, low costs, and high availability on earth. In this scenario, green biorefineries are a promising platform in which green biomasses are used as feedstock. Grasses are mainly composed of cellulose and hemicellulose, and lignin is available in a small amount. In this work, a perennial ryegrass was used as feedstock to develop a green bio-refinery platform. Firstly, the grass was mechanically pretreated, thus obtaining a press juice and a press cake fraction. The press juice has high nutritional values and can be employed as part of fermentation media. The press cake can be employed as a substrate either in enzymatic hydrolysis or in solid-state fermentation. The overall aim of this work was to demonstrate different applications of both the liquid and the solid fractions. For this purpose, the filamentous fungus A. niger and the yeast Y. lipolythica were selected for their ability to produce citric acid. Finally, the possibility was assessed to use the press juice as part of fermentation media to cultivate S. cerevisiae and lactic acid bacteria for ethanol and lactic acid fermentation.},
  language  = {en}
}
@inproceedings{UlmerBraunChengetal.2022,
  author    = {Ulmer, Jessica and Braun, Sebastian and Cheng, Chi-Tsun and Dowey, Steve and Wollert, J{\"o}rg},
  title     = {Usage of digital twins for gamification applications in manufacturing},
  series = {Procedia CIRP Leading manufacturing systems transformation - Proceedings of the 55th CIRP Conference on Manufacturing Systems 2022},
  volume    = {107},
  booktitle = {Procedia CIRP Leading manufacturing systems transformation - Proceedings of the 55th CIRP Conference on Manufacturing Systems 2022},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {2212-8271},
  doi       = {10.1016/j.procir.2022.05.044},
  pages     = {675 -- 680},
  year      = {2022},
  abstract  = {Gamification applications are on the rise in the manufacturing sector to customize working scenarios, offer user-specific feedback, and provide personalized learning offerings. Commonly, different sensors are integrated into work environments to track workers' actions. Game elements are selected according to the work task and users' preferences. However, implementing gamified workplaces remains challenging as different data sources must be established, evaluated, and connected. Developers often require information from several areas of the companies to offer meaningful gamification strategies for their employees. Moreover, work environments and the associated support systems are usually not flexible enough to adapt to personal needs. Digital twins are one primary possibility to create a uniform data approach that can provide semantic information to gamification applications. Frequently, several digital twins have to interact with each other to provide information about the workplace, the manufacturing process, and the knowledge of the employees. This research aims to create an overview of existing digital twin approaches for digital support systems and presents a concept to use digital twins for gamified support and training systems. The concept is based upon the Reference Architecture Industry 4.0 (RAMI 4.0) and includes information about the whole life cycle of the assets. It is applied to an existing gamified training system and evaluated in the Industry 4.0 model factory by an example of a handle mounting.},
  language  = {en}
}
@incollection{BauschatBennerKlingeetal.2022,
  author    = {Bauschat, J.-Michael and Benner, Miriam and Klinge, Henner and Ziegler, Simon},
  title     = {Urbane Mobilit{\"a}t entdeckt die 3. Dimension},
  series = {Transforming Mobility - What Next?},
  booktitle = {Transforming Mobility - What Next?},
  publisher = {Springer Gabler},
  address   = {Wiesbaden},
  isbn      = {978-3-658-36429-8},
  doi       = {10.1007/978-3-658-36430-4_53},
  pages     = {895 -- 916},
  year      = {2022},
  abstract  = {Der Themenkomplex urbane Mobilit{\"a}t ist getrieben durch den Verkehrsinfarkt in Ballungszentren, durch Luftverschmutzung und L{\"a}rm, sowie den Trend zum Leben in der Stadt in den st{\"a}dteplanerischen Fokus ger{\"u}ckt. Emissionsneutrale Antriebskonzepte in der Luftfahrt f{\"u}hren zu Ans{\"a}tzen Flugger{\"a}te einzusetzen, die batteriegetrieben vertikal aufsteigen und landen k{\"o}nnen. Flugphysikalisch und energetisch ist diese Technik nur dann sinnvoll, wenn es zwingende Gr{\"u}nde gibt (z.B. Rettungseins{\"a}tze), daher wird der flugphysikalische Hintergrund prinzipiell erl{\"a}utert. Es werden einige aktuelle Lufttransportkonzepte f{\"u}r eine urbane Personenbef{\"o}rderung vorgestellt. Sollte es verst{\"a}rkt zu Lufttransport {\"u}ber St{\"a}dten kommen, m{\"u}ssen betroffene Luftr{\"a}ume geordnet und {\"u}berwacht werden. Wie kompatibel Lufttransportsysteme mit den heute bereits relevanten urbanen Bef{\"o}rderungsmitteln sein m{\"u}ssen, wird kritisch diskutiert. Abschließend werden die Aspekte Akzeptanz durch die Kunden und Wirtschaftlichkeit ebenso angerissen, wie die hochproblematische Rohstoffgewinnung, die Entsorgung und das Recycling von Batterien.},
  language  = {de}
}