@incollection{PoghossianSchoening2017,
  author    = {Poghossian, Arshak and Sch{\"o}ning, Michael Josef},
  title     = {Nanomaterial-Modified Capacitive Field-Effect Biosensors},
  series = {Springer Series on Chemical Sensors and Biosensors (Methods and Applications)},
  booktitle = {Springer Series on Chemical Sensors and Biosensors (Methods and Applications)},
  publisher = {Springer},
  address   = {Berlin, Heidelberg},
  doi       = {10.1007/5346_2017_2},
  pages     = {1 -- 25},
  year      = {2017},
  abstract  = {The coupling of charged molecules, nanoparticles, and more generally, inorganic/organic nanohybrids with semiconductor field-effect devices based on an electrolyte-insulator-semiconductor (EIS) system represents a very promising strategy for the active tuning of electrochemical properties of these devices and, thus, opening new opportunities for label-free biosensing by the intrinsic charge of molecules. The simplest field-effect sensor is a capacitive EIS sensor, which represents a (bio-)chemically sensitive capacitor. In this chapter, selected examples of recent developments in the field of label-free biosensing using nanomaterial-modified capacitive EIS sensors are summarized. In the first part, we present applications of EIS sensors modified with negatively charged gold nanoparticles for the label-free electrostatic detection of positively charged small proteins and macromolecules, for monitoring the layer-by-layer formation of oppositely charged polyelectrolyte (PE) multilayers as well as for the development of an enzyme-based biomolecular logic gate. In the second part, examples of a label-free detection by means of EIS sensors modified with a positively charged weak PE layer are demonstrated. These include electrical detection of on-chip and in-solution hybridized DNA (deoxyribonucleic acid) as well as an EIS sensor with pH-responsive weak PE/enzyme multilayers for enhanced field-effect biosensing.},
  language  = {en}
}
@article{MoraisGomesSilvaetal.2017,
  author    = {Morais, Paulo V. and Gomes, Vanderley F., Jr. and Silva, Anielle C. A. and Dantas, Noelio O. and Sch{\"o}ning, Michael Josef and Siqueira, Jos{\´e} R., Jr.},
  title     = {Nanofilm of ZnO nanocrystals/carbon nanotubes as biocompatible layer for enzymatic biosensors in capacitive field-effect devices},
  series = {Journal of Materials Science},
  volume    = {52},
  journal   = {Journal of Materials Science},
  number    = {20},
  publisher = {Springer},
  address   = {Berlin},
  issn      = {1573-4803},
  doi       = {10.1007/s10853-017-1369-y},
  pages     = {12314 -- 12325},
  year      = {2017},
  abstract  = {The incorporation of nanomaterials that are biocompatible with different types of biological compounds has allowed the development of a new generation of biosensors applied especially in the biomedical field. In particular, the integration of film-based nanomaterials employed in field-effect devices can be interesting to develop biosensors with enhanced properties. In this paper, we studied the fabrication of sensitive nanofilms combining ZnO nanocrystals and carbon nanotubes (CNTs), prepared by means of the layer-by-layer (LbL) technique, in a capacitive electrolyte-insulator-semiconductor (EIS) structure for detecting glucose and urea. The ZnO nanocrystals were incorporated in a polymeric matrix of poly(allylamine) hydrochloride (PAH), and arranged with multi-walled CNTs in a LbL PAH-ZnO/CNTs film architecture onto EIS chips. The electrochemical characterizations were performed by capacitance-voltage and constant capacitance measurements, while the morphology of the films was characterized by atomic force microscopy. The enzymes glucose oxidase and urease were immobilized on film's surface for detection of glucose and urea, respectively. In order to obtain glucose and urea biosensors with optimized amount of sensitive films, we investigated the ideal number of bilayers for each detection system. The glucose biosensor showed better sensitivity and output signal for an LbL PAH-ZnO/CNTs nanofilm with 10 bilayers. On the other hand, the urea biosensor presented enhanced properties even for the first bilayer, exhibiting high sensitivity and output signal. The presence of the LbL PAH-ZnO/CNTs films led to biosensors with better sensitivity and enhanced response signal, demonstrating that the adequate use of nanostructured films is feasible for proof-of-concept biosensors with improved properties that may be employed for biomedical applications.},
  language  = {en}
}
@inproceedings{SchmidtsBoltesKraftetal.2017,
  author    = {Schmidts, Oliver and Boltes, Maik and Kraft, Bodo and Schreiber, Marc},
  title     = {Multi-pedestrian tracking by moving Bluetooth-LE beacons and stationary receivers},
  series = {2017 International Conference on Indoor Positioning and Indoor Navigation (IPIN), 18-21 September 2017, Sapporo, Japan},
  booktitle = {2017 International Conference on Indoor Positioning and Indoor Navigation (IPIN), 18-21 September 2017, Sapporo, Japan},
  pages     = {1 -- 4},
  year      = {2017},
  language  = {en}
}
@article{HorbachDuongStaat2017,
  author    = {Horbach, Andreas and Duong, Minh Tuan and Staat, Manfred},
  title     = {Modelling of compressible and orthotropic surgical mesh implants based on optical deformation measurement},
  series = {Journal of the mechanical behavior of biomedical materials},
  volume    = {74},
  journal   = {Journal of the mechanical behavior of biomedical materials},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1751-6161},
  doi       = {10.1016/j.jmbbm.2017.06.012},
  pages     = {400 -- 410},
  year      = {2017},
  language  = {en}
}
@inproceedings{SchreiberKraftZuendorf2017,
  author    = {Schreiber, Marc and Kraft, Bodo and Z{\"u}ndorf, Albert},
  title     = {Metrics Driven Research Collaboration: Focusing on Common Project Goals Continuously},
  series = {39th International Conference on Software Engineering, May 20-28, 2017 - Buenos Aires, Argentina},
  booktitle = {39th International Conference on Software Engineering, May 20-28, 2017 - Buenos Aires, Argentina},
  pages     = {8 Seiten},
  year      = {2017},
  abstract  = {Research collaborations provide opportunities for both practitioners and researchers: practitioners need solutions for difficult business challenges and researchers are looking for hard problems to solve and publish. Nevertheless, research collaborations carry the risk that practitioners focus on quick solutions too much and that researchers tackle theoretical problems, resulting in products which do not fulfill the project requirements. In this paper we introduce an approach extending the ideas of agile and lean software development. It helps practitioners and researchers keep track of their common research collaboration goal: a scientifically enriched software product which fulfills the needs of the practitioner's business model. This approach gives first-class status to application-oriented metrics that measure progress and success of a research collaboration continuously. Those metrics are derived from the collaboration requirements and help to focus on a commonly defined goal. An appropriate tool set evaluates and visualizes those metrics with minimal effort, and all participants will be pushed to focus on their tasks with appropriate effort. Thus project status, challenges and progress are transparent to all research collaboration members at any time.},
  language  = {en}
}
@inproceedings{SchreiberKraftZuendorf2017,
  author    = {Schreiber, Marc and Kraft, Bodo and Z{\"u}ndorf, Albert},
  title     = {Metrics driven research collaboration: focusing on common project goals continuously},
  series = {Proceedings : 2017 IEEE/ACM 4th International Workshop on Software Engineering Research and Industrial Practice : SER\&IP 2017 : 21 May 2017 Buenos Aires, Argentina},
  booktitle = {Proceedings : 2017 IEEE/ACM 4th International Workshop on Software Engineering Research and Industrial Practice : SER\&IP 2017 : 21 May 2017 Buenos Aires, Argentina},
  editor    = {Bilof, Randall},
  publisher = {IEEE Press},
  address   = {Piscataway, NJ},
  isbn      = {978-1-5386-2797-6},
  doi       = {10.1109/SER-IP.2017..6},
  pages     = {41 -- 47},
  year      = {2017},
  language  = {en}
}
@inproceedings{BreuerGuthmannSchoeningetal.2017,
  author    = {Breuer, Lars and Guthmann, Eric and Sch{\"o}ning, Michael Josef and Thoelen, Ronald and Wagner, Torsten},
  title     = {Light-Stimulated Hydrogels with Incorporated Graphene Oxide as Actuator Material for Flow Control in Microfluidic Applications},
  series = {Proceedings Eurosensors 2017 Conference, Paris, France, 3-6 September 2017},
  booktitle = {Proceedings Eurosensors 2017 Conference, Paris, France, 3-6 September 2017},
  doi       = {10.3390/proceedings1040524},
  pages     = {1 -- 4},
  year      = {2017},
  language  = {en}
}
@article{YoshinobuMiyamotoWerneretal.2017,
  author    = {Yoshinobu, Tatsuo and Miyamoto, Ko-ichiro and Werner, Frederik and Poghossian, Arshak and Wagner, Torsten and Sch{\"o}ning, Michael Josef},
  title     = {Light-addressable potentiometric sensors for quantitative spatial imaging of chemical species},
  series = {Annual Review of Analytical Chemistry},
  volume    = {10},
  journal   = {Annual Review of Analytical Chemistry},
  publisher = {Annual Reviews},
  address   = {Palo Alto, Calif.},
  issn      = {1936-1327},
  doi       = {10.1146/annurev-anchem-061516-045158},
  pages     = {225 -- 246},
  year      = {2017},
  abstract  = {A light-addressable potentiometric sensor (LAPS) is a semiconductor-based chemical sensor, in which a measurement site on the sensing surface is defined by illumination. This light addressability can be applied to visualize the spatial distribution of pH or the concentration of a specific chemical species, with potential applications in the fields of chemistry, materials science, biology, and medicine. In this review, the features of this chemical imaging sensor technology are compared with those of other technologies. Instrumentation, principles of operation, and various measurement modes of chemical imaging sensor systems are described. The review discusses and summarizes state-of-the-art technologies, especially with regard to the spatial resolution and measurement speed; for example, a high spatial resolution in a submicron range and a readout speed in the range of several tens of thousands of pixels per second have been achieved with the LAPS. The possibility of combining this technology with microfluidic devices and other potential future developments are discussed.},
  language  = {en}
}
@article{WernerMiyamotoWagneretal.2017,
  author    = {Werner, Frederik and Miyamoto, Ko-ichiro and Wagner, Torsten and Sch{\"o}ning, Michael Josef and Yoshinobu, Tatsuo},
  title     = {Lateral resolution enhancement of pulse-driven light-addressable potentiometric sensor},
  series = {Sensor and Actuators B: Chemical},
  volume    = {248},
  journal   = {Sensor and Actuators B: Chemical},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0925-4005},
  doi       = {10.1016/j.snb.2017.02.057},
  pages     = {961 -- 965},
  year      = {2017},
  abstract  = {To study chemical and biological processes, spatially resolved determination of the concentrations of one or more analyte species is of distinct interest. With a light-addressable potentiometric sensor (LAPS), chemical images can be created, which visualize the concentration distribution above the sensor plate. One important challenge is to achieve a good lateral resolution in order to detect events that take place in a small and limited region. LAPS utilizes a focused light spot to address the measurement region. By moving this light spot along the semiconductor sensor plate, the concentration distribution can be observed. In this study, we show that utilizing a pulse as light excitation instead of a traditionally used continuously modulated light excitation, the lateral resolution can be improved by a factor of 6 or more.},
  language  = {en}
}
@article{SchoeningBronderWuetal.2017,
  author    = {Sch{\"o}ning, Michael Josef and Bronder, Thomas and Wu, Chunsheng and Scheja, Sabrina and Jessing, Max and Metzger-Boddien, Christoph and Keusgen, Michael and Poghossian, Arshak},
  title     = {Label-Free DNA Detection with Capacitive Field-Effect Devices—Challenges and Opportunities},
  series = {Proceedings},
  volume    = {1},
  journal   = {Proceedings},
  number    = {8},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2504-3900},
  doi       = {10.3390/proceedings1080719},
  pages     = {Artikel 719},
  year      = {2017},
  abstract  = {Field-effect EIS (electrolyte-insulator-semiconductor) sensors modified with a positively charged weak polyelectrolyte layer have been applied for the electrical detection of DNA (deoxyribonucleic acid) immobilization and hybridization by the intrinsic molecular charge. The EIS sensors are able to detect the existence of target DNA amplicons in PCR (polymerase chain reaction) samples and thus, can be used as tool for a quick verification of DNA amplification and the successful PCR process. Due to their miniaturized setup, compatibility with advanced micro- and nanotechnologies, and ability to detect biomolecules by their intrinsic molecular charge, those sensors can serve as possible platform for the development of label-free DNA chips. Possible application fields as well as challenges and limitations will be discussed.},
  language  = {en}
}