@article{SchoeningKloockKnobbeetal.2004,
  author    = {Sch{\"o}ning, Michael Josef and Kloock, Joachim P. and Knobbe, D.-T. and Krause, R. and Block, K. and Wang, J. and Mulchandani, A. and Keusgen, M.},
  title     = {Direktnachweis von Pestiziden und Cyanid mit elektrochemischen Enzymsensoren},
  series = {Sensoren und Messsysteme 2004 : Tagung Ludwigsburg, 15. und 16. M{\"a}rz 2004 / VDI-VDE-Gesellschaft Mess- und Automatisierungstechnik},
  journal   = {Sensoren und Messsysteme 2004 : Tagung Ludwigsburg, 15. und 16. M{\"a}rz 2004 / VDI-VDE-Gesellschaft Mess- und Automatisierungstechnik},
  publisher = {VDI},
  address   = {D{\"u}sseldorf},
  isbn      = {3-18-091829-2},
  pages     = {699 -- 706},
  year      = {2004},
  language  = {en}
}
@article{KeusgenKloockKnobbeetal.2004,
  author    = {Keusgen, M. and Kloock, Joachim P. and Knobbe, D.-T. and J{\"u}nger, M. and Krest, I. and Goldbach, M. and Klein, W. and Sch{\"o}ning, Michael Josef},
  title     = {Direct determination of cyanides by potentiometric biosensors},
  series = {Sensors and Actuators B. 103 (2004), H. 1-2},
  journal   = {Sensors and Actuators B. 103 (2004), H. 1-2},
  isbn      = {0925-4005},
  pages     = {380 -- 385},
  year      = {2004},
  language  = {en}
}
@article{ErmolenkoVlasovKolodnikovetal.2004,
  author    = {Ermolenko, Y.E. and Vlasov, Y.G. and Kolodnikov, V.V. and Shabaldkin, D. A. and Kloock, Joachim P. and Sch{\"o}ning, Michael Josef},
  title     = {Diffusion of radioactive tracers (204Tl, 110mAg) and ionic conductivity in membrane materials for the chemical sensors},
  series = {Advances in nuclear and radiochemistry : extended abstracts of papers presented at the Sixth International Conference on Nuclear and Radiochemistry (NRC-6), 29 August to 3 September 2004, Aachen, Germany ; in cooperation with University of Cologne, GDCh, FECS, OECD-NEA and IAEA / Syed M. Qaim ... (eds.).},
  journal   = {Advances in nuclear and radiochemistry : extended abstracts of papers presented at the Sixth International Conference on Nuclear and Radiochemistry (NRC-6), 29 August to 3 September 2004, Aachen, Germany ; in cooperation with University of Cologne, GDCh, FECS, OECD-NEA and IAEA / Syed M. Qaim ... (eds.).},
  publisher = {Forschungszentrum J{\"u}lich, Zentralbibliothek},
  address   = {J{\"u}lich},
  isbn      = {3893363629},
  pages     = {483 -- 485},
  year      = {2004},
  language  = {en}
}
@article{MiyamotoYoshidaSakaietal.2011,
  author    = {Miyamoto, Ko-ichiro and Yoshida, Midori and Sakai, Taito and Matsuzaka, Atsushi and Wagner, Torsten and Kanoh, Sanoh and Yoshinobu, Tatsuo and Sch{\"o}ning, Michael Josef},
  title     = {Differential setup of light-addressable potentiometric sensor with an enzyme reactor in a flow channel},
  series = {Japanese Journal of Applied Physics. 50 (2011)},
  journal   = {Japanese Journal of Applied Physics. 50 (2011)},
  publisher = {Japan Society of Applied Physics},
  address   = {Bristol},
  isbn      = {0021-4922},
  pages     = {04DL08-1 -- 04DL08-5},
  year      = {2011},
  language  = {en}
}
@article{DantismTakenagaWagneretal.2017,
  author    = {Dantism, Shahriar and Takenaga, Shoko and Wagner, Torsten and Wagner, Patrick and Sch{\"o}ning, Michael Josef},
  title     = {Differential imaging of the metabolism of bacteria and eukaryotic cells based on light-addressable potentiometric sensors},
  series = {Electrochimica Acta},
  volume    = {246},
  journal   = {Electrochimica Acta},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0013-4686},
  doi       = {10.1016/j.electacta.2017.05.196},
  pages     = {234 -- 241},
  year      = {2017},
  abstract  = {A light-addressable potentiometric sensor (LAPS) is a field-effect-based potentiometric sensor with an electrolyte/insulator/semiconductor (EIS) structure, which is able to monitor analyte concentrations of (bio-)chemical species in aqueous solutions in a spatially resolved way. Therefore, it is also an appropriate tool to record 2D-chemical images of concentration variations on the sensor surface. In the present work, two differential, LAPS-based measurement principles are introduced to determine the metabolic activity of Escherichia coli (E. coli) K12 and Chinese hamster ovary (CHO) cells as test microorganisms. Hereby, we focus on i) the determination of the extracellular acidification rate (ΔpH/min) after adding glucose solutions to the cell suspensions; and ii) recording the amplitude increase of the photocurrent (Iph) related to the produced acids from E. coli K12 bacteria and CHO cells on the sensor surface by 2D-chemical imaging. For this purpose, 3D-printed multi-chamber structures were developed and mounted on the planar sensor-chip surface to define four independent compartments, enabling differential measurements with varying cell concentrations. The differential concept allows eliminating unwanted drift effects and, with the four-chamber structures, measurements on the different cell concentrations were performed simultaneously, thus reducing also the overall measuring time.},
  language  = {en}
}
@article{OezsoyluKizildagSchoeningetal.2020,
  author    = {{\"O}zsoylu, Dua and Kizildag, Sefa and Sch{\"o}ning, Michael Josef and Wagner, Torsten},
  title     = {Differential chemical imaging of extracellular acidification within microfluidic channels using a plasma-functionalized light-addressable potentiometric sensor (LAPS)},
  series = {Physics in Medicine},
  volume    = {10},
  journal   = {Physics in Medicine},
  number    = {100030},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {2352-4510},
  doi       = {10.1016/j.phmed.2020.100030},
  pages     = {8},
  year      = {2020},
  abstract  = {Extracellular acidification is a basic indicator for alterations in two vital metabolic pathways: glycolysis and cellular respiration. Measuring these alterations by monitoring extracellular acidification using cell-based biosensors such as LAPS plays an important role in studying these pathways whose disorders are associated with numerous diseases including cancer. However, the surface of the biosensors must be specially tailored to ensure high cell compatibility so that cells can represent more in vivo-like behavior, which is critical to gain more realistic in vitro results from the analyses, e.g., drug discovery experiments. In this work, O2 plasma patterning on the LAPS surface is studied to enhance surface features of the sensor chip, e.g., wettability and biofunctionality. The surface treated with O2 plasma for 30 s exhibits enhanced cytocompatibility for adherent CHO-K1 cells, which promotes cell spreading and proliferation. The plasma-modified LAPS chip is then integrated into a microfluidic system, which provides two identical channels to facilitate differential measurements of the extracellular acidification of CHO-K1 cells. To the best of our knowledge, it is the first time that extracellular acidification within microfluidic channels is quantitatively visualized as differential (bio-)chemical images.},
  language  = {en}
}
@article{GuoMiyamotoWagneretal.2014,
  author    = {Guo, Yuanyuan and Miyamoto, Ko-ichiro and Wagner, Torsten and Sch{\"o}ning, Michael Josef and Yoshinobu, Tatsuo},
  title     = {Device simulation of the light-addressable potentiometric sensor for the investigation of the spatial resolution},
  series = {Sensors and actuators B: Chemical},
  volume    = {204},
  journal   = {Sensors and actuators B: Chemical},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1873-3077 (E-Journal); 0925-4005 (Print)},
  doi       = {10.1016/j.snb.2014.08.016},
  pages     = {659 -- 665},
  year      = {2014},
  abstract  = {As a semiconductor-based electrochemical sensor, the light-addressable potentiometric sensor (LAPS) can realize two dimensional visualization of (bio-)chemical reactions at the sensor surface addressed by localized illumination. Thanks to this imaging capability, various applications in biochemical and biomedical fields are expected, for which the spatial resolution is critically significant. In this study, therefore, the spatial resolution of the LAPS was investigated in detail based on the device simulation. By calculating the spatiotemporal change of the distributions of electrons and holes inside the semiconductor layer in response to a modulated illumination, the photocurrent response as well as the spatial resolution was obtained as a function of various parameters such as the thickness of the Si substrate, the doping concentration, the wavelength and the intensity of illumination. The simulation results verified that both thinning the semiconductor substrate and increasing the doping concentration could improve the spatial resolution, which were in good agreement with known experimental results and theoretical analysis. More importantly, new findings of interests were also obtained. As for the dependence on the wavelength of illumination, it was found that the known dependence was not always the case. When the Si substrate was thick, a longer wavelength resulted in a higher spatial resolution which was known by experiments. When the Si substrate was thin, however, a longer wavelength of light resulted in a lower spatial resolution. This finding was explained as an effect of raised concentration of carriers, which reduced the thickness of the space charge region. The device simulation was found to be helpful to understand the relationship between the spatial resolution and device parameters, to understand the physics behind it, and to optimize the device structure and measurement conditions for realizing higher performance of chemical imaging systems.},
  language  = {en}
}
@article{IkenAhlbornGerlachetal.2013,
  author    = {Iken, Heiko and Ahlborn, K. and Gerlach, F. and Vonau, W. and Zander, W. and Schubert, J. and Sch{\"o}ning, Michael Josef},
  title     = {Development of redox glasses and subsequent processing by means of pulsed laser deposition for realizing silicon-based thin-film sensors},
  series = {Electrochimica acta},
  journal   = {Electrochimica acta},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1873-3859 (E-Journal); 0013-4686 (Print)},
  pages     = {Available online 30.8.2013},
  year      = {2013},
  language  = {en}
}
@article{MourzinaSchubertZanderetal.2001,
  author    = {Mourzina, Yu. G. and Schubert, J and Zander, W. and Legin, A. and Vlasov, Y. G. and L{\"u}th, H. and Sch{\"o}ning, Michael Josef},
  title     = {Development of multisensor systems based on chalcogenide thin film chemical sensors for the simultaneous multicomponent analysis of metal ions in complex solutions},
  series = {Scaling down in electrochemistry : electrochemical micro- and nanosystem technology ; proceedings of the 3rd International Symposium on Electrochemical Microsystem Technologies, Garmisch-Patenkirchen, Germany, 11 - 15 September 2000 / ed. by J. W. Schultz},
  journal   = {Scaling down in electrochemistry : electrochemical micro- and nanosystem technology ; proceedings of the 3rd International Symposium on Electrochemical Microsystem Technologies, Garmisch-Patenkirchen, Germany, 11 - 15 September 2000 / ed. by J. W. Schultz},
  publisher = {Elsevier [u.a.]},
  address   = {Amsterdam [u.a.]},
  isbn      = {0-08-044014-2},
  pages     = {251 -- 263},
  year      = {2001},
  language  = {en}
}
@phdthesis{Werner2014,
  author    = {Werner, Frederik},
  title     = {Development of light-addressable potentiometric sensor systems and their applications in biotechnological environments},
  pages     = {XI, 149 S.},
  year      = {2014},
  language  = {en}
}