@article{DemirciTrzewikLinderetal.2004, author = {Demirci, T. and Trzewik, J. and Linder, Peter and Digel, Ilya and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l}, title = {Mechanical Stimulation of 3T3 Fibroblasts Activates Genes: ITGB5 and p53 Responses as Quantified on the mRNA Level}, series = {Biomedizinische Technik . 49 (2004), H. Erg.-Bd. 2}, journal = {Biomedizinische Technik . 49 (2004), H. Erg.-Bd. 2}, isbn = {0932-4666}, pages = {1030 -- 1031}, year = {2004}, language = {en} } @article{RauschHarbrechtKahmannetal.2020, author = {Rausch, Valentin and Harbrecht, Andreas and Kahmann, Stephanie Lucina and Fenten, Thomas and Jovanovic, Nebojsa and Hackl, Michael and M{\"u}ller, Lars P. and Staat, Manfred and Wegmann, Kilian}, title = {Osteosynthesis of Phalangeal Fractures: Biomechanical Comparison of Kirschner Wires, Plates, and Compression Screws}, series = {The Journal of Hand Surgery}, volume = {45}, journal = {The Journal of Hand Surgery}, number = {10}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0363-5023}, doi = {10.1016/j.jhsa.2020.04.010}, pages = {987.e1 -- 987.e8}, year = {2020}, abstract = {Purpose The aim of this study was to compare several osteosynthesis techniques (intramedullary headless compression screws, T-plates, and Kirschner wires) for distal epiphyseal fractures of proximal phalanges in a human cadaveric model. Methods A total of 90 proximal phalanges from 30 specimens (index, ring, and middle fingers) were used for this study. After stripping off all soft tissue, a transverse distal epiphyseal fracture was simulated at the proximal phalanx. The 30 specimens were randomly assigned to 1 fixation technique (30 per technique), either a 3.0-mm intramedullary headless compression screw, locking plate fixation with a 2.0-mm T-plate, or 2 oblique 1.0-mm Kirschner wires. Displacement analysis (bending, distraction, and torsion) was performed using optical tracking of an applied random speckle pattern after osteosynthesis. Biomechanical testing was performed with increasing cyclic loading and with cyclic load to failure using a biaxial torsion-tension testing machine. Results Cannulated intramedullary compression screws showed significantly less displacement at the fracture site in torsional testing. Furthermore, screws were significantly more stable in bending testing. Kirschner wires were significantly less stable than plating or screw fixation in any cyclic load to failure test setup. Conclusions Intramedullary compression screws are a highly stable alternative in the treatment of transverse distal epiphyseal phalangeal fractures. Kirschner wires seem to be inferior regarding displacement properties and primary stability. Clinical relevance Fracture fixation of phalangeal fractures using plate osteosynthesis may have the advantage of a very rigid reduction, but disadvantages such as stiffness owing to the more invasive surgical approach and soft tissue irritation should be taken into account. Headless compression screws represent a minimally invasive choice for fixation with good biomechanical properties.}, language = {en} } @article{HunkerGossmannRamanetal.2021, author = {Hunker, Jan L. and Gossmann, Matthias and Raman, Aravind Hariharan and Linder, Peter}, title = {Artificial neural networks in cardiac safety assessment: Classification of chemotherapeutic compound effects on hiPSC-derived cardiomyocyte contractility}, series = {Journal of Pharmacological and Toxicological Methods}, volume = {111}, journal = {Journal of Pharmacological and Toxicological Methods}, number = {Article number 107044}, publisher = {Elsevier}, address = {New York}, issn = {1056-8719}, doi = {10.1016/j.vascn.2021.107044}, year = {2021}, language = {en} } @article{Staat2005, author = {Staat, Manfred}, title = {Local and global collapse pressure of longitudinally flawed pipes and cylindrical vessels}, year = {2005}, abstract = {Limit loads can be calculated with the finite element method (FEM) for any component, defect geometry, and loading. FEM suggests that published long crack limit formulae for axial defects under-estimate the burst pressure for internal surface defects in thick pipes while limit loads are not conservative for deep cracks and for pressure loaded crack-faces. Very deep cracks have a residual strength, which is modelled by a global collapse load. These observations are combined to derive new analytical local and global collapse loads. The global collapse loads are close to FEM limit analyses for all crack dimensions.}, subject = {Finite-Elemente-Methode}, language = {en} } @article{Staat2004, author = {Staat, Manfred}, title = {Plastic collapse analysis of longitudinally flawed pipes and vessels}, year = {2004}, abstract = {Improved collapse loads of thick-walled, crack containing pipes and vessels are suggested. Very deep cracks have a residual strength which is better modelled by a global limit load. In all burst tests, the ductility of pressure vessel steels was sufficiently high whereby the burst pressure could be predicted by limit analysis with no need to apply fracture mechanics. The relative prognosis error increases however, for long and deep defects due to uncertainties of geometry and strength data.}, subject = {Druckbeh{\"a}lter}, language = {en} } @article{StaatSchwartzLangetal.2003, author = {Staat, Manfred and Schwartz, M. and Lang, H. and Wirtz, K. and Heitzer, M.}, title = {Design by Analysis of Pressure Components by non-linear Optimization}, series = {The 10th International Conference on Pressure Vessel Technology, July 7-10, 2003, Vienna, Austria, Proceedings ICPVT-10 / Zeman, J. L. [ed]}, journal = {The 10th International Conference on Pressure Vessel Technology, July 7-10, 2003, Vienna, Austria, Proceedings ICPVT-10 / Zeman, J. L. [ed]}, publisher = {{\"O}GS, {\"O}sterreichische Gesellschaft f{\"u}r Schweißtechnik}, address = {Wien}, isbn = {3950152814}, pages = {59 -- 65}, year = {2003}, language = {en} } @article{StaatHeitzer2002, author = {Staat, Manfred and Heitzer, M.}, title = {Limit and Shakedown Analysis with Uncertain Data}, series = {Stochastic optimization techniques : numerical methods and technical applications / Marti, K. [ed]}, journal = {Stochastic optimization techniques : numerical methods and technical applications / Marti, K. [ed]}, publisher = {Springer}, address = {Heidelberg}, isbn = {3-540-42889-5}, pages = {241 -- 254}, year = {2002}, language = {en} } @article{StadlerZerlinDigeletal.2008, author = {Stadler, Andreas M. and Zerlin, Kay and Digel, Ilya and B{\"u}ldt, Georg and Zaccai, Guiseppe and Artmann, Gerhard}, title = {Dynamics and interactions of hemoglobin in red blood cells}, series = {Tissue Engineering Part A. 14 (2008), H. 5}, journal = {Tissue Engineering Part A. 14 (2008), H. 5}, isbn = {1937-3341}, pages = {724 -- 724}, year = {2008}, language = {en} } @article{Dachwald2005, author = {Dachwald, Bernd}, title = {Optimization of very-low-thrust trajectories using evolutionary neurocontrol}, series = {Acta Astronautica}, volume = {57}, journal = {Acta Astronautica}, number = {2-8}, publisher = {Elsevier}, address = {Amsterdam [u.a.]}, isbn = {1879-2030}, pages = {175 -- 185}, year = {2005}, abstract = {Searching optimal interplanetary trajectories for low-thrust spacecraft is usually a difficult and time-consuming task that involves much experience and expert knowledge in astrodynamics and optimal control theory. This is because the convergence behavior of traditional local optimizers, which are based on numerical optimal control methods, depends on an adequate initial guess, which is often hard to find, especially for very-low-thrust trajectories that necessitate many revolutions around the sun. The obtained solutions are typically close to the initial guess that is rarely close to the (unknown) global optimum. Within this paper, trajectory optimization problems are attacked from the perspective of artificial intelligence and machine learning. Inspired by natural archetypes, a smart global method for low-thrust trajectory optimization is proposed that fuses artificial neural networks and evolutionary algorithms into so-called evolutionary neurocontrollers. This novel method runs without an initial guess and does not require the attendance of an expert in astrodynamics and optimal control theory. This paper details how evolutionary neurocontrol works and how it could be implemented. The performance of the method is assessed for three different interplanetary missions with a thrust to mass ratio <0.15mN/kg (solar sail and nuclear electric).}, language = {en} } @article{AkimbekovDigelTastambeketal.2013, author = {Akimbekov, Nuraly S. and Digel, Ilya and Tastambek, K. T. and Zhubanova, A. A.}, title = {Biocompatibility of carbonized rice husk with a rat heart cells line H9c2}, series = {Experimental Biology}, volume = {59}, journal = {Experimental Biology}, number = {3/1}, issn = {1563-0218}, pages = {23 -- 25}, year = {2013}, language = {en} }