@article{JordanKruegerWillmesetal.2011, author = {Jordan, Sabine D. and Kr{\"u}ger, Markus and Willmes, Diana M. and Redemann, Nora and Wunderlich, F. Thomas and Br{\"o}nneke, Hella S. and Merkwirth, Carsten and Kashkar, Hamid and Olkkonen, Vesa M. and B{\"o}ttger, Thomas and Braun, Thomas and Seibler, Jost and Br{\"u}ning, Jens C.}, title = {Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism}, series = {Nature Cell Biology}, volume = {13}, journal = {Nature Cell Biology}, number = {4}, publisher = {Nature}, address = {New York}, issn = {1465-7392}, doi = {10.1038/ncb2211}, pages = {434 -- 446}, year = {2011}, abstract = {The contribution of altered post-transcriptional gene silencing to the development of insulin resistance and type 2 diabetes mellitus so far remains elusive. Here, we demonstrate that expression of microRNA (miR)-143 and 145 is upregulated in the liver of genetic and dietary mouse models of obesity. Induced transgenic overexpression of miR-143, but not miR-145, impairs insulin-stimulated AKT activation and glucose homeostasis. Conversely, mice deficient for the miR-143-145 cluster are protected from the development of obesity-associated insulin resistance. Quantitative-mass-spectrometry-based analysis of hepatic protein expression in miR-143-overexpressing mice revealed miR-143-dependent downregulation of oxysterol-binding-protein-related protein (ORP) 8. Reduced ORP8 expression in cultured liver cells impairs the ability of insulin to induce AKT activation, revealing an ORP8-dependent mechanism of AKT regulation. Our experiments provide direct evidence that dysregulated post-transcriptional gene silencing contributes to the development of obesity-induced insulin resistance, and characterize the miR-143-ORP8 pathway as a potential target for the treatment of obesity-associated diabetes.}, language = {en} } @article{BongaertsEsserLorbachetal.2011, author = {Bongaerts, Johannes and Esser, Simon and Lorbach, Volker and Al-Momani, L{\´o}ay and M{\"u}ller, Michael A. and Franke, Dirk and Grondal, Christoph and Kurutsch, Anja and Bujnicki, Robert and Takors, Ralf and Raeven, Leon and Wubbolts, Marcel and Bovenberg, Roel and Nieger, Martin and Sch{\"u}rmann, Melanie and Trachtmann, Natalie and Kozak, Stefan and Sprenger, Georg A. and M{\"u}ller, Michael}, title = {Diversity-oriented production of metabolites derived from chorismate and their use in organic synthesis}, series = {Angewandte Chemie International Edition}, volume = {Vol. 50}, journal = {Angewandte Chemie International Edition}, number = {Iss. 34}, publisher = {Wiley}, address = {Weinheim}, issn = {1521-3773 (E-Journal); 0570-0833 (Print); 1433-7851 (Print)}, pages = {7781 -- 7786}, year = {2011}, language = {en} } @article{Bung2011, author = {Bung, Daniel Bernhard}, title = {Fließcharakteristik und Sauerstoffeintrag bei selbstbel{\"u}fteten Gerinnestr{\"o}mungen auf Kaskaden mit gem{\"a}ßigter Neigung}, series = {{\"O}sterreichische Wasser- und Abfallwirtschaft}, volume = {Vol. 63}, journal = {{\"O}sterreichische Wasser- und Abfallwirtschaft}, number = {Iss. 3-4}, publisher = {Springer}, address = {Berlin}, issn = {1613-7566 (E-Journal); 0945-358X (Print)}, pages = {76 -- 81}, year = {2011}, language = {de} } @incollection{MeskourisNordaButenweg2011, author = {Meskouris, Konstantin and Norda, Hannah and Butenweg, Christoph}, title = {Aktuelle Nachweiskonzepte von Mauerwerk unter Erdbebenbeanspruchung}, series = {Wie wollen wir in Zukunft bauen? : Festschrift zum 60. Geburtstag von Prof. Dr.-Ing. Wolfram J{\"a}ger, Dresden, 19.04.2011. (Bauforschung und Baupraxis ; H. 10)}, booktitle = {Wie wollen wir in Zukunft bauen? : Festschrift zum 60. Geburtstag von Prof. Dr.-Ing. Wolfram J{\"a}ger, Dresden, 19.04.2011. (Bauforschung und Baupraxis ; H. 10)}, publisher = {Techn. Univ., Lehrstuhl Tragwerksplanung}, address = {Dresden}, isbn = {978-3-86780-216-1}, pages = {233 -- 238}, year = {2011}, language = {de} } @inproceedings{HoltschoppenCornelissenButenwegetal.2011, author = {Holtschoppen, Britta and Cornelissen, Philipp and Butenweg, Christoph and Meskouris, Konstantin}, title = {Vereinfachtes Berechnungsverfahren zur Ber{\"u}cksichtigung der Interaktionsschwingung bei fl{\"u}ssigkeitsgef{\"u}llten Tankbauwerken unter seismischer Belastung}, series = {Berichte der Fachtagung Baustatik-Baupraxis 11 : am 21. und 22. Februar 2011 an der Universit{\"a}t Innsbruck / Hrsg. Gernot Beer ...}, booktitle = {Berichte der Fachtagung Baustatik-Baupraxis 11 : am 21. und 22. Februar 2011 an der Universit{\"a}t Innsbruck / Hrsg. Gernot Beer ...}, publisher = {Inst. f{\"u}r Baustatik, Techn. Univ. Graz}, address = {Graz}, organization = {Fachtagung Baustatik, Baupraxis <11, 2011, Innsbruck>}, isbn = {978-3-85125-115-9}, pages = {155 -- 162}, year = {2011}, language = {de} } @inproceedings{ZiolkoFrickeAnthrakidisetal.2011, author = {Ziolko, Christoph and Fricke, Barbara and Anthrakidis, Anette and Hoffschmidt, Bernhard and Dillig, Marius and Giese, Frank and Schwarzb{\"o}zl, Peter}, title = {{\"O}kobilanzielle Aspekte technologischer Entwicklungen des Solarturmkraftwerks}, series = {Forschung und Entwicklung f{\"u}r solarthermische Kraftwerke : 14. K{\"o}lner Sonnenkolloquium Mittwoch, 13. Juli 2011, im Auditorium des Campus J{\"u}lich der FH Aachen : Kurzfassungen der Vortr{\"a}ge und Poster}, booktitle = {Forschung und Entwicklung f{\"u}r solarthermische Kraftwerke : 14. K{\"o}lner Sonnenkolloquium Mittwoch, 13. Juli 2011, im Auditorium des Campus J{\"u}lich der FH Aachen : Kurzfassungen der Vortr{\"a}ge und Poster}, publisher = {DLR}, address = {K{\"o}ln}, pages = {2 S.}, year = {2011}, language = {de} } @inproceedings{ButenwegMeskourisMeisteretal.2011, author = {Butenweg, Christoph and Meskouris, Konstantin and Meister, Sylvia and Dreyer, Stephan and Schulte-Althoff, Christoph}, title = {Technisches Informationssystem f{\"u}r die Entwicklung textilbewehrten Betons}, series = {Textilbeton in Theorie und Praxis : Tagungsband zum 6. Kolloquium zu Textilbewehrten Tragwerken (CTRS6) in Berlin am 19. und 20.9.2011 / Technische Universit{\"a}t Dresden, Sonderforschungsbereich 528, herausgegeben von Manfred Curbach und Regine Ortlepp}, booktitle = {Textilbeton in Theorie und Praxis : Tagungsband zum 6. Kolloquium zu Textilbewehrten Tragwerken (CTRS6) in Berlin am 19. und 20.9.2011 / Technische Universit{\"a}t Dresden, Sonderforschungsbereich 528, herausgegeben von Manfred Curbach und Regine Ortlepp}, publisher = {Technische Universit{\"a}t}, address = {Dresden}, organization = {Kolloquium zu Textilbewehrten Tragwerken <6, 2011, Dresden>}, isbn = {978-3-86780-122-5}, pages = {257 -- 268}, year = {2011}, language = {de} } @article{Bung2011, author = {Bung, Daniel Bernhard}, title = {Developing flow in skimming flow regime on embankment stepped spillways}, series = {Journal of hydraulic research}, volume = {Vol. 49}, journal = {Journal of hydraulic research}, number = {Iss. 5}, publisher = {Taylor \& Francis}, address = {London}, issn = {1814-2079 (E-Journal); 0022-1686 (Print)}, pages = {639 -- 648}, year = {2011}, language = {en} } @article{FerreinMaraisPotgieteretal.2011, author = {Ferrein, Alexander and Marais, Stephen and Potgieter, Anet and Steinbauer, Gerald}, title = {RoboCup Junior: A vehicle for S\&T education in Africa?}, publisher = {IEEE}, address = {New York}, isbn = {978-1-61284-992-8}, pages = {1 -- 6}, year = {2011}, language = {en} } @inproceedings{SchifferFerreinLakemeyer2011, author = {Schiffer, Stefan and Ferrein, Alexander and Lakemeyer, Gerhard}, title = {Fuzzy representations and control for domestic service robots in Golog}, series = {Intelligent robotics and applications : 4th International conference, ICIRA 2011, Aachen, Germany, December 6-8, 2011, proceedings, part I. (Lecture notes in computer science ; 7102)}, booktitle = {Intelligent robotics and applications : 4th International conference, ICIRA 2011, Aachen, Germany, December 6-8, 2011, proceedings, part I. (Lecture notes in computer science ; 7102)}, isbn = {978-3-642-25486-4}, pages = {241 -- 250}, year = {2011}, language = {en} }