@article{DantismTakenagaWagneretal.2015,
  author    = {Dantism, S. and Takenaga, S. and Wagner, P. and Wagner, Torsten and Sch{\"o}ning, Michael Josef},
  title     = {Light-addressable Potentiometric Sensor (LAPS) Combined with Multi-chamber Structures to Investigate the Metabolic Activity of Cells},
  series = {Procedia Engineering},
  volume    = {120},
  journal   = {Procedia Engineering},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1877-7058},
  doi       = {10.1016/j.proeng.2015.08.647},
  pages     = {384 -- 387},
  year      = {2015},
  abstract  = {LAPS are field-effect-based potentiometric sensors which are able to monitor analyte concentrations in a spatially resolved manner. Hence, a LAPS sensor system is a powerful device to record chemical imaging of the concentration of chemical species in an aqueous solution, chemical reactions, or the growth of cell colonies on the sensor surface, to record chemical images. In this work, multi-chamber 3D-printed structures made out of polymer (PP-ABS) were combined with LAPS chips to analyse differentially and simultaneously the metabolic activity of Escherichia coli K12 and Chinese hamster ovary (CHO) cells, and the responds of those cells to the addition of glucose solution.},
  language  = {en}
}
@article{WagnerVornholtWerneretal.2016,
  author    = {Wagner, Torsten and Vornholt, Wolfgang and Werner, Frederik and Yoshinobu, Tatsuo and Miyamoto, Ko-Ichiro and Keusgen, Michael and Sch{\"o}ning, Michael Josef},
  title     = {Light-addressable potentiometric sensor (LAPS) combined with magnetic beads for pharmaceutical screening},
  series = {Physics in medicine},
  volume    = {2016},
  journal   = {Physics in medicine},
  number    = {1},
  issn      = {2352-4510},
  doi       = {10.1016/j.phmed.2016.03.001},
  pages     = {2 -- 7},
  year      = {2016},
  abstract  = {The light-addressable potentiometric sensor (LAPS) has the unique feature to address different regions of a sensor surface without the need of complex structures. Measurements at different locations on the sensor surface can be performed in a common analyte solution, which distinctly simplifies the fluidic set-up. However, the measurement in a single analyte chamber prevents the application of different drugs or different concentrations of a drug to each measurement spot at the same time as in the case of multi-reservoir-based set-ups. In this work, the authors designed a LAPS-based set-up for cell culture screening that utilises magnetic beads loaded with the endotoxin (lipopolysaccharides, LPS), to generate a spatially distributed gradient of analyte concentration. Different external magnetic fields can be adjusted to move the magnetic beads loaded with a specific drug within the measurement cell. By recording the metabolic activities of a cell layer cultured on top of the LAPS surface, this work shows the possibility to apply different concentrations of a sample along the LAPS measurement spots within a common analyte solution.},
  language  = {en}
}
@article{WeldenSchoeningWagneretal.2020,
  author    = {Welden, Rene and Sch{\"o}ning, Michael Josef and Wagner, Patrick H. and Wagner, Torsten},
  title     = {Light-Addressable Electrodes for Dynamic and Flexible Addressing of Biological Systems and Electrochemical Reactions},
  series = {Sensors},
  volume    = {20},
  journal   = {Sensors},
  number    = {6},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {1424-8220},
  doi       = {10.3390/s20061680},
  pages     = {Artikel 1680},
  year      = {2020},
  abstract  = {In this review article, we are going to present an overview on possible applications of light-addressable electrodes (LAE) as actuator/manipulation devices besides classical electrode structures. For LAEs, the electrode material consists of a semiconductor. Illumination with a light source with the appropiate wavelength leads to the generation of electron-hole pairs which can be utilized for further photoelectrochemical reaction. Due to recent progress in light-projection technologies, highly dynamic and flexible illumination patterns can be generated, opening new possibilities for light-addressable electrodes. A short introduction on semiconductor-electrolyte interfaces with light stimulation is given together with electrode-design approaches. Towards applications, the stimulation of cells with different electrode materials and fabrication designs is explained, followed by analyte-manipulation strategies and spatially resolved photoelectrochemical deposition of different material types.},
  language  = {en}
}
@inproceedings{WagnerYoshinobuOttoetal.2006,
  author    = {Wagner, Torsten and Yoshinobu, T. and Otto, R. and Rao, C. and Molina, R. and Sch{\"o}ning, Michael Josef},
  title     = {Licht-adressierbare potentiometrische Sensorsysteme - Konzepte und Anwendungen},
  series = {Sensoren und Mess-Systeme 2006 : Vortr{\"a}ge der 13. ITG/GMA-Fachtagung vom 13. bis 14.3.2006 in Freiburg/Breisgau},
  booktitle = {Sensoren und Mess-Systeme 2006 : Vortr{\"a}ge der 13. ITG/GMA-Fachtagung vom 13. bis 14.3.2006 in Freiburg/Breisgau},
  publisher = {VDE Verl.},
  address   = {Berlin},
  isbn      = {3-8007-2939-3},
  pages     = {165 -- 168},
  year      = {2006},
  language  = {de}
}
@article{MoraisSumanSchoeningetal.2023,
  author    = {Morais, Paulo V. and Suman, Pedro H. and Sch{\"o}ning, Michael Josef and Siqueira Junior, Jos{\´e} R. and Orlandi, Marcelo O.},
  title     = {Layer-by-layer film based on Sn₃O₄ nanobelts as sensing units to detect heavy metals using a capacitive field-effect sensor platform},
  series = {Chemosensors},
  volume    = {11},
  journal   = {Chemosensors},
  number    = {8},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2227-9040},
  doi       = {10.3390/chemosensors11080436},
  pages     = {Artikel 436},
  year      = {2023},
  abstract  = {Lead and nickel, as heavy metals, are still used in industrial processes, and are classified as "environmental health hazards" due to their toxicity and polluting potential. The detection of heavy metals can prevent environmental pollution at toxic levels that are critical to human health. In this sense, the electrolyte-insulator-semiconductor (EIS) field-effect sensor is an attractive sensing platform concerning the fabrication of reusable and robust sensors to detect such substances. This study is aimed to fabricate a sensing unit on an EIS device based on Sn₃O₄ nanobelts embedded in a polyelectrolyte matrix of polyvinylpyrrolidone (PVP) and polyacrylic acid (PAA) using the layer-by-layer (LbL) technique. The EIS-Sn₃O₄ sensor exhibited enhanced electrochemical performance for detecting Pb²⁺ and Ni²⁺ ions, revealing a higher affinity for Pb²⁺ ions, with sensitivities of ca. 25.8 mV/decade and 2.4 mV/decade, respectively. Such results indicate that Sn₃O₄ nanobelts can contemplate a feasible proof-of-concept capacitive field-effect sensor for heavy metal detection, envisaging other future studies focusing on environmental monitoring.},
  language  = {en}
}
@article{SiqueiraWernerBaeckeretal.2009,
  author    = {Siqueira, Jose R. and Werner, Frederik and B{\"a}cker, Matthias and Poghossian, Arshak and Zucolotto, Valtencir and Oliveira, Osvaldo N. Jr. and Sch{\"o}ning, Michael Josef},
  title     = {Layer-by-Layer Assembly of Carbon Nanotubes Incorporated in Light-Addressable Potentiometric Sensors},
  series = {Journal of Physical Chemistry C. 113 (2009), H. 33},
  journal   = {Journal of Physical Chemistry C. 113 (2009), H. 33},
  publisher = {American Chemical Society},
  address   = {Washington, DC},
  isbn      = {1932-7455},
  pages     = {14765 -- 14770},
  year      = {2009},
  language  = {en}
}
@article{WernerMiyamotoWagneretal.2017,
  author    = {Werner, Frederik and Miyamoto, Ko-ichiro and Wagner, Torsten and Sch{\"o}ning, Michael Josef and Yoshinobu, Tatsuo},
  title     = {Lateral resolution enhancement of pulse-driven light-addressable potentiometric sensor},
  series = {Sensor and Actuators B: Chemical},
  volume    = {248},
  journal   = {Sensor and Actuators B: Chemical},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0925-4005},
  doi       = {10.1016/j.snb.2017.02.057},
  pages     = {961 -- 965},
  year      = {2017},
  abstract  = {To study chemical and biological processes, spatially resolved determination of the concentrations of one or more analyte species is of distinct interest. With a light-addressable potentiometric sensor (LAPS), chemical images can be created, which visualize the concentration distribution above the sensor plate. One important challenge is to achieve a good lateral resolution in order to detect events that take place in a small and limited region. LAPS utilizes a focused light spot to address the measurement region. By moving this light spot along the semiconductor sensor plate, the concentration distribution can be observed. In this study, we show that utilizing a pulse as light excitation instead of a traditionally used continuously modulated light excitation, the lateral resolution can be improved by a factor of 6 or more.},
  language  = {en}
}
@article{ErmolenkoYoshinobuMourzinaetal.2004,
  author    = {Ermolenko, Y. E. and Yoshinobu, T. and Mourzina, Y. G. and Vlasov, Y. G. and Sch{\"o}ning, Michael Josef and Iwasaki, H.},
  title     = {Laserscanned transducer (LSST) as a multisensor system},
  series = {Sensors and Actuators B. 103 (2004), H. 1-2},
  journal   = {Sensors and Actuators B. 103 (2004), H. 1-2},
  isbn      = {0925-4005},
  pages     = {457 -- 462},
  year      = {2004},
  language  = {en}
}
@article{DantismRoehlenDahmenetal.2020,
  author    = {Dantism, Shahriar and R{\"o}hlen, Desiree and Dahmen, Markus and Wagner, Torsten and Wagner, Patrick and Sch{\"o}ning, Michael Josef},
  title     = {LAPS-based monitoring of metabolic responses of bacterial cultures in a paper fermentation broth},
  series = {Sensors and Actuators B: Chemical},
  volume    = {320},
  journal   = {Sensors and Actuators B: Chemical},
  number    = {Art. 128232},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0925-4005},
  doi       = {10.1016/j.snb.2020.128232},
  year      = {2020},
  abstract  = {As an alternative renewable energy source, methane production in biogas plants is gaining more and more attention. Biomass in a bioreactor contains different types of microorganisms, which should be considered in terms of process-stability control. Metabolically inactive microorganisms within the fermentation process can lead to undesirable, time-consuming and cost-intensive interventions. Hence, monitoring of the cellular metabolism of bacterial populations in a fermentation broth is crucial to improve the biogas production, operation efficiency, and sustainability. In this work, the extracellular acidification of bacteria in a paper-fermentation broth is monitored after glucose uptake, utilizing a differential light-addressable potentiometric sensor (LAPS) system. The LAPS system is loaded with three different model microorganisms (Escherichia coli, Corynebacterium glutamicum, and Lactobacillus brevis) and the effect of the fermentation broth at different process stages on the metabolism of these bacteria is studied. In this way, different signal patterns related to the metabolic response of microorganisms can be identified. By means of calibration curves after glucose uptake, the overall extracellular acidification of bacterial populations within the fermentation process can be evaluated.},
  language  = {en}
}
@article{SchoeningKloock2004,
  author    = {Sch{\"o}ning, Michael Josef and Kloock, Joachim P.},
  title     = {Labor f{\"u}r Chemo- und Biosensorik an der FH Aachen, Abt. J{\"u}lich - Mehr als nur studieren},
  series = {Fachblatt Fachhochschule Aachen (2004)},
  journal   = {Fachblatt Fachhochschule Aachen (2004)},
  isbn      = {1430-7707},
  pages     = {18 -- 19},
  year      = {2004},
  language  = {de}
}