@article{EngelmannBuhlDraacketal.2018, author = {Engelmann, Ulrich M. and Buhl, Eva Miriam and Draack, Sebastian and Viereck, Thilo and Frank, and Schmitz-Rode, Thomas and Slabu, Ioana}, title = {Magnetic relaxation of agglomerated and immobilized iron oxide nanoparticles for hyperthermia and imaging applications}, series = {IEEE Magnetic Letters}, volume = {9}, journal = {IEEE Magnetic Letters}, number = {Article number 8519617}, publisher = {IEEE}, address = {New York, NY}, issn = {1949-307X}, doi = {10.1109/LMAG.2018.2879034}, year = {2018}, abstract = {Magnetic nanoparticles (MNPs) are used as therapeutic and diagnostic agents for local delivery of heat and image contrast enhancement in diseased tissue. Besides magnetization, the most important parameter that determines their performance for these applications is their magnetic relaxation, which can be affected when MNPs immobilize and agglomerate inside tissues. In this letter, we investigate different MNP agglomeration states for their magnetic relaxation properties under excitation in alternating fields and relate this to their heating efficiency and imaging properties. With focus on magnetic fluid hyperthermia, two different trends in MNP heating efficiency are measured: an increase by up to 23\% for agglomerated MNP in suspension and a decrease by up to 28\% for mixed states of agglomerated and immobilized MNP, which indicates that immobilization is the dominant effect. The same comparatively moderate effects are obtained for the signal amplitude in magnetic particle spectroscopy.}, language = {en} } @article{QuittmannMeskemperAbeletal.2018, author = {Quittmann, Oliver J. and Meskemper, Joshua and Abel, Thomas and Albracht, Kirsten and Foitschik, Tina and Rojas-Vega, Sandra and Str{\"u}der, Heiko K.}, title = {Kinematics and kinetics of handcycling propulsion at increasing workloads in able-bodied subjects}, series = {Sports Engineereing}, volume = {21}, journal = {Sports Engineereing}, number = {21}, publisher = {Springer Nature}, address = {Cham}, issn = {1460-2687}, doi = {10.1007/s12283-018-0269-y}, pages = {283 -- 294}, year = {2018}, abstract = {In Paralympic sports, biomechanical optimisation of movements and equipment seems to be promising for improving performance. In handcycling, information about the biomechanics of this sport is mainly provided by case studies. The aim of the current study was (1) to examine changes in handcycling propulsion kinematics and kinetics due to increasing workloads and (2) identify parameters that are associated with peak aerobic performance. Twelve non-disabled male competitive triathletes without handcycling experience voluntarily participated in the study. They performed an initial familiarisation protocol and incremental step test until exhaustion in a recumbent racing handcycle that was attached to an ergometer. During the incremental test, tangential crank kinetics, 3D joint kinematics, blood lactate and ratings of perceived exertion (local and global) were identified. As a performance criterion, the maximal power output during the step test (Pmax) was calculated and correlated with biomechanical parameters. For higher workloads, an increase in crank torque was observed that was even more pronounced in the pull phase than in the push phase. Furthermore, participants showed an increase in shoulder internal rotation and abduction and a decrease in elbow flexion and retroversion. These changes were negatively correlated with performance. At high workloads, it seems that power output is more limited by the transition from pull to push phase than at low workloads. It is suggested that successful athletes demonstrate small alterations of their kinematic profile due to increasing workloads. Future studies should replicate and expand the test spectrum (sprint and continuous loads) as well as use methods like surface electromyography (sEMG) with elite handcyclists.}, language = {de} } @article{ConzenAlbannaWeissetal.2018, author = {Conzen, Catharina and Albanna, Walid and Weiss, Miriam and K{\"u}rten, David and Vilser, Walthard and Kotliar, Konstantin and Z{\"a}ske, Charlotte and Clusmann, Hans and Schubert, Gerrit Alexander}, title = {Vasoconstriction and Impairment of Neurovascular Coupling after Subarachnoid Hemorrhage: a Descriptive Analysis of Retinal Changes}, series = {Translational Stroke Research}, journal = {Translational Stroke Research}, number = {9}, publisher = {Springer Nature}, address = {Cham}, issn = {1868-601X}, doi = {10.1007/s12975-017-0585-8}, pages = {284 -- 293}, year = {2018}, abstract = {Impaired cerebral autoregulation and neurovascular coupling (NVC) contribute to delayed cerebral ischemia after subarachnoid hemorrhage (SAH). Retinal vessel analysis (RVA) allows non-invasive assessment of vessel dimension and NVC hereby demonstrating a predictive value in the context of various neurovascular diseases. Using RVA as a translational approach, we aimed to assess the retinal vessels in patients with SAH. RVA was performed prospectively in 24 patients with acute SAH (group A: day 5-14), in 11 patients 3 months after ictus (group B: day 90 ± 35), and in 35 age-matched healthy controls (group C). Data was acquired using a Retinal Vessel Analyzer (Imedos Systems UG, Jena) for examination of retinal vessel dimension and NVC using flicker-light excitation. Diameter of retinal vessels—central retinal arteriolar and venular equivalent—was significantly reduced in the acute phase (p < 0.001) with gradual improvement in group B (p < 0.05). Arterial NVC of group A was significantly impaired with diminished dilatation (p < 0.001) and reduced area under the curve (p < 0.01) when compared to group C. Group B showed persistent prolonged latency of arterial dilation (p < 0.05). Venous NVC was significantly delayed after SAH compared to group C (A p < 0.001; B p < 0.05). To our knowledge, this is the first clinical study to document retinal vasoconstriction and impairment of NVC in patients with SAH. Using non-invasive RVA as a translational approach, characteristic patterns of compromise were detected for the arterial and venous compartment of the neurovascular unit in a time-dependent fashion. Recruitment will continue to facilitate a correlation analysis with clinical course and outcome.}, language = {en} } @article{RiekeStollenwerkDahmenetal.2018, author = {Rieke, Christian and Stollenwerk, Dominik and Dahmen, Markus and Pieper, Martin}, title = {Modeling and optimization of a biogas plant for a demand-driven energy supply}, series = {Energy}, volume = {145}, journal = {Energy}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0360-5442}, doi = {10.1016/j.energy.2017.12.073}, pages = {657 -- 664}, year = {2018}, abstract = {Due to the Renewable Energy Act, in Germany it is planned to increase the amount of renewable energy carriers up to 60\%. One of the main problems is the fluctuating supply of wind and solar energy. Here biogas plants provide a solution, because a demand-driven supply is possible. Before running such a plant, it is necessary to simulate and optimize the process. This paper provides a new model of a biogas plant, which is as accurate as the standard ADM1 model. The advantage compared to ADM1 is that it is based on only four parameters compared to 28. Applying this model, an optimization was installed, which allows a demand-driven supply by biogas plants. Finally the results are confirmed by several experiments and measurements with a real test plant.}, language = {en} } @incollection{PielenRoethFlatten2018, author = {Pielen, Michael and R{\"o}th, Thilo and Flatten, T.}, title = {Erfolgsfaktoren k{\"u}nftiger Gesch{\"a}ftsmodelle von urbanen, geteilten Mobilit{\"a}tsdienstleistungen}, series = {Mobilit{\"a}t und digitale Transformation. (9. Wissenschaftsforum Mobilit{\"a}t. Tagungsband)}, booktitle = {Mobilit{\"a}t und digitale Transformation. (9. Wissenschaftsforum Mobilit{\"a}t. Tagungsband)}, editor = {Proff, H.}, publisher = {Springer Gabler}, address = {Wiesbaden}, isbn = {978-3-658-20779-3}, doi = {10.1007/978-3-658-20779-3_2}, pages = {435 -- 448}, year = {2018}, abstract = {Digitalisierung bezeichnet die Nutzung großer Datenmengen, die zu einer umfassenden Vernetzung aller Bereiche der Wirtschaft und Gesellschaft f{\"u}hren wird (BMWi, 2015 und {\"a}hnlich K{\"o}hler/Wollschl{\"a}ger, 2014: 79). Sie umfasst die Erhebung von analogen Informationen („Big Data" in einem engen Sinne; z.B. O´Leary, 2013), ihre Speicherung in einem digitaltechnischen System (lokale Speicherung oder „Cloud Computing" durch die Weiterentwickelung des Internets; z.B. Hashem et al., 2015: 101), die Analyse und Interpretation sowie den Transfer in andere Systeme („Internet der Dinge" bzw. „Internet of Things"; z.B. Ashton, 2009).}, language = {de} } @article{OberlaenderMayerGreeffetal.2018, author = {Oberl{\"a}nder, Jan and Mayer, Marlena and Greeff, Anton and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Spore-based biosensor to monitor the microbicidal efficacy of gaseous hydrogen peroxide sterilization processes}, series = {Biosensors and Bioelectronics}, volume = {104}, journal = {Biosensors and Bioelectronics}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0956-5663}, doi = {10.1016/j.bios.2017.12.045}, pages = {87 -- 94}, year = {2018}, abstract = {In this work, a spore-based biosensor is evaluated to monitor the microbicidal efficacy of sterilization processes applying gaseous hydrogen peroxide (H2O2). The sensor is based on interdigitated electrode structures (IDEs) that have been fabricated by means of thin-film technologies. Impedimetric measurements are applied to study the effect of sterilization process on spores of Bacillus atrophaeus. This resilient microorganism is commonly used in industry to proof the sterilization efficiency. The sensor measurements are accompanied by conventional microbiological challenge tests, as well as morphological characterizations with scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The sensor measurements are correlated with the microbiological test routines. In both methods, namely the sensor-based and microbiological one, a tailing effect has been observed. The results are evaluated and discussed in a three-dimensional calibration plot demonstrating the sensor's suitability to enable a rapid process decision in terms of a successfully performed sterilization.}, language = {en} } @incollection{ChwallekGoelzerReichert2018, author = {Chwallek, Constanze and G{\"o}lzer, Kaan and Reichert, Walter}, title = {Faymonville - Wachstum als Komplexit{\"a}tstreiber}, series = {Fallstudienkompendium Hidden Champions - Innovationen f{\"u}r den Weltmarkt}, booktitle = {Fallstudienkompendium Hidden Champions - Innovationen f{\"u}r den Weltmarkt}, publisher = {Springer Gabler}, isbn = {978-3-658-17829-1}, doi = {10.1007/978-3-658-17829-1_18}, pages = {299 -- 312}, year = {2018}, abstract = {Die Fallstudie FAYMONVILLE besch{\"a}ftigt sich damit, wie es dem Familienunternehmen Faymonville aus Ostbelgien gelungen ist, sich zu einem der f{\"u}hrenden Hersteller in seiner Branche zu entwickeln. Die gezielte Identifizierung neuer M{\"a}rkte, die Fokussierung auf die relevanten Kundenbed{\"u}rfnisse und eine konsistente Produktpolitik mit einem abgestimmten Fertigungskonzept legen die Grundsteine f{\"u}r den Erfolg. Das vorliegende Fallbeispiel zeigt anschaulich, wie es gelingen kann, den prinzipiellen Widerspruch zwischen wirtschaftlicher und kundenindividueller Fertigung erfolgreich aufzul{\"o}sen.}, language = {de} } @misc{OPUS4-8741, title = {Dimensionen 2-2018: Magazin der FH Aachen University of Applied Sciences - Virtuelle Realit{\"a}ten}, address = {Aachen}, organization = {FH Aachen, University of Applied Sciences}, pages = {63 Seiten}, year = {2018}, abstract = {Virtuelle Realit{\"a}ten Inhaltsverzeichnis 6 Erweiterte Dimensionen: Special zum Thema Virtual Reality 10 "VR und AR werden unsere Welt durchdringen": Ein Interview zum Potenzial von Virtual und Augmented Reality 14 Lernen aus einem anderen Blickwinkel: VR wird in Studium und Lehre zunehmend angewandt 18 Parallele Realit{\"a}ten in der Forschung: Virtual und Augmented Reality in Forschungsprojekten 22 Willkommen in der Welt der M{\"o}glichkeiten: Wie real ist die Illusion der Realit{\"a}t 24 Eine z{\"u}ndende Idee: Institut f{\"u}r Mikrowellen- und Plasmatechnik (IMP) entwickelt neue Plasmaz{\"u}ndkerze f{\"u}r sparsamere Benzinmotoren 28 Der Elefant im Park: "WESTPARK story constructed": Studierende bauen skulpturales M{\"o}bel 30 Herr Bernoulli geht auf Reisen: Das "aero | race lab" bringt Experimente zur Luft- und Raumfahrt an die Schulen 32 Eine Auszeit vom Alltag: Martin Stockberg schafft Kunstwerke im Sand 36 Der Einer im urbanen Mobilit{\"a}tstetris: An der FH Aachen wird urbane Elektromobilit{\"a}t neu gedacht 39 Der Primzahlw{\"u}rfel: Kopfnuss 40 Schwarz Weiß Bunt: Die politische Kunst des FH-Absolventen Ralf Metzenmacher 44 Die Champions League des Schweißens: LaVa-X will das Laserstrahlschweißen im Vakuum etablieren 46 Auf der Suche nach dem goldenen Schnatz: St{\"o}cke statt Besen. Spielfeld statt Arena. In J{\"u}lich spielen Studierende Quidditch. 48 Bei ihm wird Science-Fiction zu Science-Fact: Volker Schmid erz{\"a}hlt von seiner Arbeit beim Deutschen Zentrum f{\"u}r Luft- und Raumfahrt (DLR) 52 Die Ideenschmieden: Junge Menschen aus aller Welt diskutieren bei den Summerschools {\"u}ber Zukunftsthemen 56 Forschung auf h{\"o}chstem Niveau: Dr. Jan Oberl{\"a}nder und Doktorand Dua {\"O}zsoylu stehen f{\"u}r das, was das Institut f{\"u}r Nano- und Biotechnologien auszeichnet 58 Der Dom und ich: Dompublikation und LEGO-Throne zum Jubil{\"a}um 40 Jahre UNESCO-Weltkulturerbe 62 Sag "Ja" zum Studium: Der neue kooperative Bachelorstudiengang "Elektrotechnik mit Orientierungssemester" 63 Impressum}, language = {de} } @article{LauraDrechslerErdtetal.2018, author = {Laura, C.O. and Drechsler, Klaus and Erdt, M. and Wesarg, S. and Bale, R.}, title = {Intervention assessment tool for primary tumors in the liver}, series = {Current Directions in Biomedical Engineering}, volume = {4}, journal = {Current Directions in Biomedical Engineering}, number = {1}, publisher = {De Gruyter}, address = {Berlin}, issn = {2364-5504}, doi = {10.1515/cdbme-2018-0081}, pages = {337 -- 340}, year = {2018}, abstract = {After a liver tumor intervention the medical doctor has to compare both pre and postoperative CT acquisitions to ensure that all carcinogenic cells are destroyed. A correct assessment of the intervention is of vital importance, since it will reduce the probability of tumor recurrence. Some methods have been proposed to support the medical doctors during the assessment process, however, all of them focus on secondary tumors. In this paper a tool is presented that enables the outcome validation for both primary and secondary tumors. Therefore, a multiphase registration (preoperative arterial and portal phases) followed by a registration between the pre and postoperative CT images is carried out. The first registration is in charge of the primary tumors that are only visible in the arterial phase. The secondary tumors will be incorporated in the second registration step. Finally, the part of the tumor that was not covered by the necrosis is quantified and visualized. The method has been tested in 9 patients, with an average registration error of 1.41 mm.}, language = {en} } @article{HeinkeKnickerAlbracht2018, author = {Heinke, Lars N. and Knicker, Axel J. and Albracht, Kirsten}, title = {Evaluation of passively induced shoulder stretch reflex using an isokinetic dynamometer in male overhead athletes}, series = {Isokinetics and Exercise Science}, volume = {26}, journal = {Isokinetics and Exercise Science}, number = {4}, publisher = {IOS Press}, address = {Amsterdam}, issn = {1878-5913}, doi = {10.3233/IES-184111}, pages = {265 -- 274}, year = {2018}, abstract = {BACKGROUND: Muscle stretch reflexes are widely considered to beneficially influence joint stability and power generation in the lower limbs. While in the upper limbs and especially in the muscles surrounding the shoulder joint such evidence is lacking. OBJECTIVE: To quantify the electromyographical response in the muscles crossing the shoulder of specifically trained overhead athletes to an anterior perturbation force. METHODS: Twenty healthy male participants performed six sets of different external shoulder rotation stretches on an isokinetic dynamometer over a range of amplitudes and muscle pre-activation moment levels. All stretches were applied with a dynamometer acceleration of 10,000∘/s2 and a velocity of 150∘/s. Electromyographical response was measured via sEMG. RESULTS: Consistent reflexes were not observed in all experimental conditions. The reflex latencies revealed a significant muscle main effect (F (2,228) = 99.31, p< 0.001; η2= 0.466; f= 0.934) and a pre-activation main effect (F (1,228) = 142.21, p< 0.001; η2= 0.384; f= 1.418). The stretch reflex amplitude yielded a significant pre-activation main effect (F (1,222) = 470.373, p< 0.001; η2= 0.679; f= 1.454). CONCLUSION: Short latency muscle reflexes showed a tendency to an anterior to posterior muscle recruitment whereby the main internal rotator muscles of the shoulder revealed the most consistent results.}, language = {en} }