@article{KotliarLanzl2011, author = {Kotliar, Konstantin and Lanzl, Ines M.}, title = {Can vascular function be assessed by the interpretation of retinal vascular diameter changes?}, series = {Investigative Ophthalmology \& Visual Science, IOVS. 52 (2011), H. 1}, journal = {Investigative Ophthalmology \& Visual Science, IOVS. 52 (2011), H. 1}, publisher = {ARVO}, address = {Rockville, Md.}, isbn = {0146-0404}, pages = {635 -- 636}, year = {2011}, language = {en} } @article{KotliarMueckeVilseretal.2008, author = {Kotliar, Konstantin and M{\"u}cke, Bruno and Vilser, Walthard and Schilling, Rudolf}, title = {Effect of aging on retinal artery blood column diameter measured along the vessel axis / Kotliar, Konstantin E. ; M{\"u}cke, Bruno ; Vilser, Walthard ; Schilling, Rudolf ; Lanzl, Ines M.}, series = {Investigative Ophthalmology \& Visual Science, IOVS. 49 (2008), H. 5}, journal = {Investigative Ophthalmology \& Visual Science, IOVS. 49 (2008), H. 5}, publisher = {-}, isbn = {0146-0404}, pages = {2094 -- 2102}, year = {2008}, language = {en} } @article{KotliarLanzlHanssenetal.2012, author = {Kotliar, Konstantin and Lanzl, Ines M. and Hanssen, Henner and Eberhardt, Karla and Vilser, Walthard and Halle, Martin and Heemann, Uwe and Schmidt-Trucks{\"a}ss, Arno and Baumann, Marcus}, title = {Does increased blood pressure rather than aging influence retinal pulse wave velocity?}, series = {Investigative Ophthalmology \& Visual Science, IOVS}, volume = {53}, journal = {Investigative Ophthalmology \& Visual Science, IOVS}, number = {4}, publisher = {ARVO}, address = {Rockville, Md.}, issn = {0146-0404}, doi = {10.1167/iovs.11-8815}, pages = {2119 -- 2126}, year = {2012}, abstract = {Purpose: It was demonstrated previously that retinal pulse wave velocity (rPWV) as a measure of retinal arterial stiffness is increased in aged anamnestically healthy volunteers compared with young healthy subjects. Using novel methodology of rPWV assessment this finding was confirmed and investigated whether it might relate to the increased blood pressure usually accompanying the aging process, rather than to the aging itself. Methods: A total of 12 young 25.5-year-old (24.0-28.8) [median(1st quartile-3rd quartile)] and 12 senior 68.5-year-old (63.8-71.8) anamnestically healthy volunteers; and 12 senior 63.0-year-old (60.8-65.0) validated healthy volunteers and 12 young 33.0-year-old (29.5-35.0) hypertensive patients were examined. Time-dependent alterations of vessel diameter were assessed by the Dynamic Vessel Analyzer in a retinal artery of each subject. The data were filtered and processed using mathematical signal analysis and rPWVs were calculated. Results: rPWV amounted to 1200 (990-1470) RU (relative units)/s in the hypertensive group and to 1040 (700-2230) RU/s in anamnestically healthy seniors. These differed significantly from rPWVs in young healthy group (410 [280-500] RU/s) and in validated healthy seniors (400 [320-510] RU/s). rPWV associated with age and mean arterial pressure (MAP) in the pooled cohort excluded validated healthy seniors. In a regression model these associations remain when alternately adjusted for MAP and age. When including validated healthy seniors in the pooled cohort only association with MAP remains. Conclusions: Both aging (with not excluded cardiovascular risk factors) and mild hypertension are associated with elevated rPWV. rPWV increases to a similar extent both in young mildly hypertensive subjects and in aged anamnestically healthy persons. Healthy aging is not associated with increased rPWV.}, language = {en} } @article{LustfeldPithanReissel2012, author = {Lustfeld, H. and Pithan, C. and Reißel, Martin}, title = {Metallic electrolyte composites in the framework of the brick-layer model}, series = {Journal of the European Ceramic Society}, volume = {32}, journal = {Journal of the European Ceramic Society}, number = {4}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0955-2219}, doi = {10.1016/j.jeurceramsoc.2011.10.017}, pages = {859 -- 864}, year = {2012}, abstract = {It is well known that the already large dielectric constants of some electrolytes like BaTiO₃ can be enhanced further by adding metallic (e.g. Ni, Cu or Ag) nanoparticles. The enhancement can be quite large, a factor of more than 1000 is possible. The consequences for the properties will be discussed in the present paper applying a brick-layer model (BLM) for calculating dc-resistivities of thin layers and a modified one (PBLM) that includes percolation for calculating dielectric properties of these materials. The PBLM results in an at least qualitative description and understanding of the physical phenomena: This model gives an explanation for the steep increase of the dielectric constant below the percolation threshold and why this increase is connected to a dramatic decrease of the breakdown voltage as well as the ability of storing electrical energy. We conclude that metallic electrolyte composites like BaTiO₃ are not appropriate for energy storage.}, language = {en} } @article{BohrnStuetzFuchsetal.2012, author = {Bohrn, U. and St{\"u}tz, E. and Fuchs, K. and Fleischer, M. and Sch{\"o}ning, Michael Josef and Wagner, P.}, title = {Monitoring of irritant gas using a whole-cell-based sensor system}, series = {Sensors and Actuators B: Chemical}, volume = {175}, journal = {Sensors and Actuators B: Chemical}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0925-4005}, doi = {10.1016/j.snb.2012.05.088}, pages = {208 -- 217}, year = {2012}, abstract = {Cell-based sensors for the detection of gases have long been underrepresented, due to the cellular requirement of being cultured in a liquid environment. In this work we established a cell-based gas biosensor for the detection of toxic substances in air, by adapting a commercial sensor chip (Bionas®), previously used for the measurement of pollutants in liquids. Cells of the respiratory tract (A549, RPMI 2650, V79), which survive at a gas phase in a natural context, are used as biological receptors. The physiological cell parameters acidification, respiration and morphology are continuously monitored in parallel. Ammonia was used as a highly water-soluble model gas to test the feasibility of the sensor system. Infrared measurements confirmed the sufficiency of the medium draining method. This sensor system provides a basis for many sensor applications such as environmental monitoring, building technology and public security.}, language = {en} } @article{HillenAlperSelverFischeretal.2007, author = {Hillen, Walter and Alper Selver, M. and Fischer, Felix and Kuntalp, Mehmet}, title = {A software tool for interactive generation, representation, and systematical storage of transfer functions for 3D medical images / Alper Selver, M. ; Fischer, Felix ; Kuntalp, Mehmet ; Hillen, Walter}, series = {Computer Methods and Programs in Biomedicine. 86 (2007), H. 3}, journal = {Computer Methods and Programs in Biomedicine. 86 (2007), H. 3}, publisher = {-}, isbn = {0169-2607}, pages = {270 -- 280}, year = {2007}, language = {en} } @article{KurulganDemirciDemirciLinderetal.2012, author = {Kurulgan Demirci, Eylem and Demirci, Taylan and Linder, Peter and Trzewik, J{\"u}rgen and Gierkowski, Jessica Ricarda and Gossmann, Matthias and Kayser, Peter and Porst, Dariusz and Digel, Ilya and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l}, title = {rhAPC reduces the endothelial cell permeability via a decrease of contractile tensions induced by endothelial cells}, series = {Journal of Bioscience and Bioengineering}, volume = {113}, journal = {Journal of Bioscience and Bioengineering}, number = {2}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1347-4421}, doi = {10.1016/j.jbiosc.2012.03.019}, pages = {212 -- 219}, year = {2012}, abstract = {All cells generate contractile tension. This strain is crucial for mechanically controlling the cell shape, function and survival. In this study, the CellDrum technology quantifying cell's (the cellular) mechanical tension on a pico-scale was used to investigate the effect of lipopolysaccharide (LPS) on human aortic endothelial cell (HAoEC) tension. The LPS effect during gram-negative sepsis on endothelial cells is cell contraction causing endothelium permeability increase. The aim was to finding out whether recombinant activated protein C (rhAPC) would reverse the endothelial cell response in an in-vitro sepsis model. In this study, the established in-vitro sepsis model was confirmed by interleukin 6 (IL-6) levels at the proteomic and genomic levels by ELISA, real time-PCR and reactive oxygen species (ROS) activation by florescence staining. The thrombin cellular contraction effect on endothelial cells was used as a positive control when the CellDrum technology was applied. Additionally, the Ras homolog gene family, member A (RhoA) mRNA expression level was checked by real time-PCR to support contractile tension results. According to contractile tension results, the mechanical predominance of actin stress fibers was a reason of the increased endothelial contractile tension leading to enhanced endothelium contractility and thus permeability enhancement. The originality of this data supports firstly the basic measurement principles of the CellDrum technology and secondly that rhAPC has a beneficial effect on sepsis influenced cellular tension. The technology presented here is promising for future high-throughput cellular tension analysis that will help identify pathological contractile tension responses of cells and prove further cell in-vitro models.}, language = {en} } @article{HanssenNickelDrexeletal.2011, author = {Hanssen, H. and Nickel, T. and Drexel, V. and Hertel, G. and Emslander, I. and Sisic, Z. and Lorang, D. and Schuster, T. and Kotliar, Konstantin and Pressler, A. and Schmidt-Trucks{\"a}ss, A. and Weis, M. and Halle, M.}, title = {Exercise-induced alterations of retinal vessel diameters and cardiovascular risk reduction in obesity}, series = {Atherosclerosis}, volume = {216}, journal = {Atherosclerosis}, number = {2}, publisher = {Elsevier}, address = {Amsterdam}, isbn = {0021-9150}, pages = {433 -- 439}, year = {2011}, language = {en} } @article{KirchnerReisertPuetzetal.2012, author = {Kirchner, Patrick and Reisert, Steffen and P{\"u}tz, Patrick and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Characterisation of polymeric materials as passivation layer for calorimetric H2O2 gas sensors}, series = {Physica Status Solidi (a)}, volume = {209}, journal = {Physica Status Solidi (a)}, number = {5}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.201100773}, pages = {859 -- 863}, year = {2012}, abstract = {Calorimetric gas sensors for monitoring the H₂O₂ concentration at elevated temperatures in industrial sterilisation processes have been presented in previous works. These sensors are built up in form of a differential set-up of a catalytically active and passive temperature-sensitive structure. Although, various types of catalytically active dispersions have been studied, the passivation layer has to be established and therefore, chemically as well as physically characterised. In the present work, fluorinated ethylene propylene (FEP), perfluoralkoxy (PFA) and epoxy-based SU-8 photoresist as temperature-stable polymeric materials have been investigated for sensor passivation in terms of their chemical inertness against H₂O₂, their hygroscopic properties as well as their morphology. The polymeric materials were deposited via spin-coating on the temperature-sensitive structure, wherein spin-coated FEP and PFA show slight agglomerates. However, they possess a low absorption of humidity due to their hydrophobic surface, whereas the SU-8 layer has a closed surface but shows a slightly higher absorption of water. All of them were inert against gaseous H₂O₂ during the characterisation in H₂O₂ atmosphere that demonstrates their suitability as passivation layer for calorimetric H₂O₂ gas sensors.}, language = {en} } @article{SpelthahnKirsanovLeginetal.2012, author = {Spelthahn, Heiko and Kirsanov, Dmitry and Legin, Andrey and Osterrath, Thomas and Schubert, J{\"u}rgen and Zander, Willi and Sch{\"o}ning, Michael Josef}, title = {Development of a thin-film sensor array for analytical monitoring of heavy metals in aqueous solutions}, series = {Physica Status Solidi (a)}, volume = {209}, journal = {Physica Status Solidi (a)}, number = {5}, publisher = {Wiley-VCH}, address = {Weinheim}, isbn = {1862-6319}, doi = {10.1002/pssa.201100733}, pages = {885 -- 891}, year = {2012}, abstract = {In industrial processes there is a variety of heavy metals (e.g., copper, zinc, cadmium, and lead) in use for wires, coatings, paints, alloys, batteries, etc. Since the application of these transition metals for industry is inevitable, it is a vital task to develop proper analytical techniques for their monitoring at low activity levels, especially because most of these elements are acutely toxic for biological organisms. The determination of ions in solution by means of a simple and inexpensive sensor array is, therefore, a promising task. In this work, a sensor array with heavy metal-sensitive chalcogenide glass membranes for the simultaneous detection of the four ions Ag⁺, Cu2⁺, Cd2⁺, and Pb2⁺ in solution is realized. The results of the physical characterization by means of microscopy, profilometry, Rutherford backscattering spectroscopy (RBS), and scanning electron microscopy (SEM) as well as the electrochemical characterization by means of potentiometric measurements are presented. Additionally, the possibility to expand the sensor array by polymeric sensor membranes is discussed.}, language = {en} }