@article{MonakhovaDiehl2022,
  author    = {Monakhova, Yulia and Diehl, Bernd W.K.},
  title     = {Multinuclear NMR screening of pharmaceuticals using standardization by 2H integral of a deuterated solvent},
  series = {Journal of Pharmaceutical and Biomedical Analysis},
  volume    = {209},
  journal   = {Journal of Pharmaceutical and Biomedical Analysis},
  number    = {Article number: 114530},
  publisher = {Elsevier},
  isbn      = {0731-7085},
  doi       = {10.1016/j.jpba.2021.114530},
  year      = {2022},
  abstract  = {NMR standardization approach that uses the 2H integral of deuterated solvent for quantitative multinuclear analysis of pharmaceuticals is described. As a proof of principle, the existing NMR procedure for the analysis of heparin products according to US Pharmacopeia monograph is extended to the determination of Na+ and Cl- content in this matrix. Quantification is performed based on the ratio of a 23Na (35Cl) NMR integral and 2H NMR signal of deuterated solvent, D2O, acquired using the specific spectrometer hardware. As an alternative, the possibility of 133Cs standardization using the addition of Cs2CO3 stock solution is shown. Validation characteristics (linearity, repeatability, sensitivity) are evaluated. A holistic NMR profiling of heparin products can now also be used for the quantitative determination of inorganic compounds in a single analytical run using a single sample. In general, the new standardization methodology provides an appealing alternative for the NMR screening of inorganic and organic components in pharmaceutical products.},
  language  = {en}
}
@article{OezsoyluKizildagSchoeningetal.2020,
  author    = {{\"O}zsoylu, Dua and Kizildag, Sefa and Sch{\"o}ning, Michael Josef and Wagner, Torsten},
  title     = {Differential chemical imaging of extracellular acidification within microfluidic channels using a plasma-functionalized light-addressable potentiometric sensor (LAPS)},
  series = {Physics in Medicine},
  volume    = {10},
  journal   = {Physics in Medicine},
  number    = {100030},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {2352-4510},
  doi       = {10.1016/j.phmed.2020.100030},
  pages     = {8},
  year      = {2020},
  abstract  = {Extracellular acidification is a basic indicator for alterations in two vital metabolic pathways: glycolysis and cellular respiration. Measuring these alterations by monitoring extracellular acidification using cell-based biosensors such as LAPS plays an important role in studying these pathways whose disorders are associated with numerous diseases including cancer. However, the surface of the biosensors must be specially tailored to ensure high cell compatibility so that cells can represent more in vivo-like behavior, which is critical to gain more realistic in vitro results from the analyses, e.g., drug discovery experiments. In this work, O2 plasma patterning on the LAPS surface is studied to enhance surface features of the sensor chip, e.g., wettability and biofunctionality. The surface treated with O2 plasma for 30 s exhibits enhanced cytocompatibility for adherent CHO-K1 cells, which promotes cell spreading and proliferation. The plasma-modified LAPS chip is then integrated into a microfluidic system, which provides two identical channels to facilitate differential measurements of the extracellular acidification of CHO-K1 cells. To the best of our knowledge, it is the first time that extracellular acidification within microfluidic channels is quantitatively visualized as differential (bio-)chemical images.},
  language  = {en}
}
@inproceedings{SildatkeKarwanniKraftetal.2020,
  author    = {Sildatke, Michael and Karwanni, Hendrik and Kraft, Bodo and Schmidts, Oliver and Z{\"u}ndorf, Albert},
  title     = {Automated Software Quality Monitoring in Research Collaboration Projects},
  series = {ICSEW'20: Proceedings of the IEEE/ACM 42nd International Conference on Software Engineering Workshops},
  booktitle = {ICSEW'20: Proceedings of the IEEE/ACM 42nd International Conference on Software Engineering Workshops},
  publisher = {IEEE},
  address   = {New York, NY},
  doi       = {10.1145/3387940.3391478},
  pages     = {603 -- 610},
  year      = {2020},
  abstract  = {In collaborative research projects, both researchers and practitioners work together solving business-critical challenges. These projects often deal with ETL processes, in which humans extract information from non-machine-readable documents by hand. AI-based machine learning models can help to solve this problem. Since machine learning approaches are not deterministic, their quality of output may decrease over time. This fact leads to an overall quality loss of the application which embeds machine learning models. Hence, the software qualities in development and production may differ. Machine learning models are black boxes. That makes practitioners skeptical and increases the inhibition threshold for early productive use of research prototypes. Continuous monitoring of software quality in production offers an early response capability on quality loss and encourages the use of machine learning approaches. Furthermore, experts have to ensure that they integrate possible new inputs into the model training as quickly as possible. In this paper, we introduce an architecture pattern with a reference implementation that extends the concept of Metrics Driven Research Collaboration with an automated software quality monitoring in productive use and a possibility to auto-generate new test data coming from processed documents in production. Through automated monitoring of the software quality and auto-generated test data, this approach ensures that the software quality meets and keeps requested thresholds in productive use, even during further continuous deployment and changing input data.},
  language  = {en}
}
@article{EngelmannPourshahidiShalabyetal.2022,
  author    = {Engelmann, Ulrich M. and Pourshahidi, Mohammad Ali and Shalaby, Ahmed and Krause, Hans-Joachim},
  title     = {Probing particle size dependency of frequency mixing magnetic detection with dynamic relaxation simulation},
  series = {Journal of Magnetism and Magnetic Materials},
  volume    = {563},
  journal   = {Journal of Magnetism and Magnetic Materials},
  number    = {In progress, Art. No. 169965},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0304-8853},
  doi       = {10.1016/j.jmmm.2022.169965},
  year      = {2022},
  abstract  = {Biomedical applications of magnetic nanoparticles (MNP) fundamentally rely on the particles' magnetic relaxation as a response to an alternating magnetic field. The magnetic relaxation complexly depends on the interplay of MNP magnetic and physical properties with the applied field parameters. It is commonly accepted that particle core size is a major contributor to signal generation in all the above applications, however, most MNP samples comprise broad distribution spanning nm and more. Therefore, precise knowledge of the exact contribution of individual core sizes to signal generation is desired for optimal MNP design generally for each application. Specifically, we present a magnetic relaxation simulation-driven analysis of experimental frequency mixing magnetic detection (FMMD) for biosensing to quantify the contributions of individual core size fractions towards signal generation. Applying our method to two different experimental MNP systems, we found the most dominant contributions from approx. 20 nm sized particles in the two independent MNP systems. Additional comparison between freely suspended and immobilized MNP also reveals insight in the MNP microstructure, allowing to use FMMD for MNP characterization, as well as to further fine-tune its applicability in biosensing.},
  language  = {en}
}
@article{AchtsnichtToedterNiehuesetal.2019,
  author    = {Achtsnicht, Stefan and T{\"o}dter, Julia and Niehues, Julia and Tel{\"o}ken, Matthias and Offenh{\"a}usser, Andreas and Krause, Hans-Joachim and Schr{\"o}per, Florian},
  title     = {3D printed modular immunofiltration columns for frequency mixing-based multiplex magnetic immunodetection},
  series = {Sensors},
  volume    = {19},
  journal   = {Sensors},
  number    = {1},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {1424-8220},
  doi       = {10.3390/s19010148},
  pages     = {15 Seiten},
  year      = {2019},
  abstract  = {For performing point-of-care molecular diagnostics, magnetic immunoassays constitute a promising alternative to established enzyme-linked immunosorbent assays (ELISA) because they are fast, robust and sensitive. Simultaneous detection of multiple biomolecular targets from one body fluid sample is desired. The aim of this work is to show that multiplex magnetic immunodetection based on magnetic frequency mixing by means of modular immunofiltration columns prepared for different targets is feasible. By calculations of the magnetic response signal, the required spacing between the modules was determined. Immunofiltration columns were manufactured by 3D printing and antibody immobilization was performed in a batch approach. It was shown experimentally that two different target molecules in a sample solution could be individually detected in a single assaying step with magnetic measurements of the corresponding immobilization filters. The arrangement order of the filters and of a negative control did not influence the results. Thus, a simple and reliable approach to multi-target magnetic immunodetection was demonstrated.},
  language  = {en}
}
@misc{Buechel2022,
  type      = {Master Thesis},
  author    = {B{\"u}chel, Carolin},
  title     = {GYMLET : dein mobiles Freiluftstudio - Entwicklung eines serientauglichen Prototypen und einer Vermarktungsstrategie},
  publisher = {FH Aachen},
  address   = {Aachen},
  pages     = {93 Seiten},
  year      = {2022},
  abstract  = {Sportvereine verlieren zunehmend Mitglieder. Grund daf{\"u}r ist der wachsende Wunsch nach unabh{\"a}ngigen Trainingsm{\"o}glichkeiten. GYMLET bietet den Sportler:innen die M{\"o}glichkeit, ihre Fitness funktional, selbstorganisiert und unabh{\"a}ngig zu trainieren. Dabei kann durch den selbstbestimmten Trainingsort neben der k{\"o}rperlichen Fitness vor allem die Motivation zur sportlichen Aktivit{\"a}t und das Wohlbefinden gesteigert werden. Unterst{\"u}tzt wird das Trainingssystem durch eine App, welche den Sportler:innen neben Nutzungsm{\"o}glichkeiten als Coach und Trainingsplaner dient. Um diese Trainingsm{\"o}glichkeit an die Zielgruppe heranzutragen, ist eine Kampagnenstrategie aus zwei Phasen entstanden. In dieser sollen Postings und Clips {\"u}ber Instagram und Youtube ver{\"o}ffentlicht werden. Zus{\"a}tzlich werden Zeitschriften und m{\"o}gliche Kooperationen mit Therapeuten oder Freizeitunterk{\"u}nften zur Ver{\"o}ffentlichung der Kampagne genutzt.},
  language  = {de}
}
@article{HeuermannSadeghfam2009,
  author    = {Heuermann, Holger and Sadeghfam, Arash},
  title     = {Enhanced system architecture for rugged wide band data transmission / Sadeghfam, A. ; Heuermann, H.},
  series = {European Radar Conference, 2009 : EuRAD 2009 ; Sept. 30 - Oct. 2 2009, Rome, Italy ; part of the European Microwave Week (EuMW) / sponsored by EuMA, European Microwave Association},
  journal   = {European Radar Conference, 2009 : EuRAD 2009 ; Sept. 30 - Oct. 2 2009, Rome, Italy ; part of the European Microwave Week (EuMW) / sponsored by EuMA, European Microwave Association},
  publisher = {IEEE},
  address   = {Piscataway, NJ},
  isbn      = {978-2-87487-014-9},
  pages     = {347 -- 350},
  year      = {2009},
  language  = {en}
}
@book{KrauseUlkeMartinetal.2019,
  author    = {Krause, Thomas and Ulke, Bernd and Martin, Joachim and Lemke, J{\"o}rg and Sparla, Peter and Streit, Wilfried},
  title     = {{\"U}bungsaufgaben und Berechnungen f{\"u}r den Baubetrieb: Klausurvorbereitung mit ausf{\"u}hrlichen L{\"o}sungen},
  editor    = {Krause, Thomas and Ulke, Bernd},
  edition   = {3. Auflage},
  publisher = {Springer Vieweg},
  address   = {Wiesbaden},
  isbn      = {978-3-658-23126-2 (Print) 978-3-658-23127-9 (Online)},
  pages     = {XI, 347 Seiten ; Illustrationen},
  year      = {2019},
  language  = {de}
}
@masterthesis{Frank2022,
  type      = {Bachelor Thesis},
  author    = {Frank, Jemima Leonie},
  title     = {Falling in love with the female gaze},
  publisher = {FH Aachen},
  address   = {Aachen},
  school      = {Fachhochschule Aachen},
  pages     = {81 Seiten},
  year      = {2022},
  abstract  = {Der „Male Gaze" bezeichnet das typische Erleben der Umwelt aus m{\"a}nnlicher Perspektive und pr{\"a}gt in den sogenannten Mainstream-Medien die Gestaltung von Film, Fernsehen und Werbung. Dadurch werden von dargestellten Personen h{\"a}ufig die k{\"o}rperlichen Aspekte hervorgehoben. Im Gegensatz dazu gilt das weibliche Pendant, der „Female Gaze", als besonders emotionsbetont. Weil Medien einen enormen Einfluss auf gesellschaftliches und individuelles Denken haben, stellt die Dominanz des „Male Gaze" eine Unausgeglichenheit dar, die sich in verschiedenen Bereichen des gesellschaftlichen Lebens widerspiegelt. Deswegen m{\"o}chte dieses Projekt die Medien um die weibliche Sichtweise erweitern und damit die dort transportierten Bilder diverser und ausgewogener machen. Die Fotografie fokussiert sich dabei auf die Gef{\"u}hlswelt der Protagonistin, womit die Betrachter:Innen schrittweise in ihre Position hineinversetzt werden sollen. Mit Augen des Mitgef{\"u}hls und eigenem Sch{\"o}nheitsbegriff l{\"a}sst „Falling in love with the female gaze" endlich auch die Frau zu Wort kommen.},
  language  = {de}
}
@masterthesis{Mueller2021,
  type      = {Bachelor Thesis},
  author    = {M{\"u}ller, Elona},
  title     = {Aus den Augen aus dem Sinn?: Ein Bookazine deckt das Problem des Unsichtbaren M{\"u}lls auf},
  publisher = {FH Aachen},
  address   = {Aachen},
  school      = {Fachhochschule Aachen},
  year      = {2021},
  abstract  = {M{\"u}ll ist immer und {\"u}berall vorhanden - auch wenn wir ihn nicht sehen. Gerade unsichtbarer M{\"u}ll birgt f{\"u}r den Menschen und seine Umwelt erhebliche Gefahren, die durch seine Unsichtbarkeit irrelevant erscheinen. Die Publikation mit dem Titel mikromakro deckt durch verschiedene Artikel, Interviews und Texte die Gefahren auf, die durch den unsichtbaren M{\"u}ll entstehen. Ziel war es, eine Bookazine-Reihe zu konzipieren, die in sechs Ausgaben das Thema des unsichtbaren M{\"u}lls beleuchtet. Die erste Ausgabe zum Thema Kunststoff wurde exemplarisch gestaltet. Zus{\"a}tzlich zum redaktionellen Teil untermauern Infografiken die Texte faktisch und Fotoserien emotional. Da unsichtbarer M{\"u}ll auf zwei Ebenen zu finden ist - der Makro- (groß) und Mikroebene (klein) - wurde die Publikation inhaltlich zweigeteilt, sodass sich das Layout und die Fotoserien vom Mikro- und Makroteil unterscheiden. },
  language  = {de}
}