@inproceedings{WolfWiese2013,
  author    = {Wolf, Martin R. and Wiese, Ute},
  title     = {A comparative transformation model for process changes using serious games},
  series = {2013 IEEE 2nd International Conference on Serious Games and Applications for Health (SeGAH): proceedings of a meeting held 2-3 May 2013, Algarve, Portugal},
  booktitle = {2013 IEEE 2nd International Conference on Serious Games and Applications for Health (SeGAH): proceedings of a meeting held 2-3 May 2013, Algarve, Portugal},
  publisher = {Institute of Electrical and Electronics Engineers (IEEE)},
  address   = {Piscataway, NJ},
  organization    = {International Conference on Serious Games and Applications for Health <2, 2013, Algarve>},
  isbn      = {978-1-4673-6164-4},
  doi       = {10.1109/SeGAH.2013.6665307},
  pages     = {64 -- 70},
  year      = {2013},
  language  = {en}
}
@article{HoughNalwalkDingetal.2015,
  author    = {Hough, Lindsay B. and Nalwalk, Julia W. and Ding, Xinxin and Scheer, Nico},
  title     = {Opioid Analgesia in P450 Gene Cluster Knockout Mice: A Search for Analgesia-Relevant Isoforms},
  series = {Drug Metabolism and Disposition},
  volume    = {43},
  journal   = {Drug Metabolism and Disposition},
  number    = {9},
  issn      = {1521-009x},
  doi       = {10.1124/dmd.115.065490},
  pages     = {1326 -- 1330},
  year      = {2015},
  language  = {en}
}
@inproceedings{Laack2016,
  author    = {Laack, Walter van},
  title     = {Schnittstelle Tod: Wo stehen wir nach 40 Jahren NTE-Forschung?},
  publisher = {van Laack GmbH},
  address   = {Aachen},
  isbn      = {978-3-936624-30-4 (Print-Ausgabe)},
  url       = {http://nbn-resolving.de/urn:nbn:de:101:1-201603132912},
  pages     = {92 Seiten},
  year      = {2016},
  language  = {de}
}
@techreport{AdomeitWillms1984,
  author    = {Adomeit, G. and Willms, Herbert},
  title     = {Experimental investigation of the acceleration of deflagration in wake flow : final report. - (Euratom-publications-EUR ; 9593 : Nuclear science and technology)},
  publisher = {Commission of the European Communities},
  address   = {Luxembourg},
  isbn      = {92-825-4699-3},
  pages     = {III, 119 S.},
  year      = {1984},
  language  = {en}
}
@article{HaegerProbstJaegeretal.2023,
  author    = {Haeger, Gerrit and Probst, Johanna and Jaeger, Karl-Erich and Bongaerts, Johannes and Siegert, Petra},
  title     = {Novel aminoacylases from Streptomyces griseus DSM 40236 and their recombinant production in Streptomyces lividans},
  series = {FEBS Open Bio},
  volume    = {13},
  journal   = {FEBS Open Bio},
  number    = {12},
  publisher = {Wiley},
  address   = {Hoboken, NJ},
  issn      = {2211-5463},
  doi       = {10.1002/2211-5463.13723},
  pages     = {2224 -- 2238},
  year      = {2023},
  abstract  = {Amino acid-based surfactants are valuable compounds for cosmetic formulations. The chemical synthesis of acyl-amino acids is conventionally performed by the Schotten-Baumann reaction using fatty acyl chlorides, but aminoacylases have also been investigated for use in biocatalytic synthesis with free fatty acids. Aminoacylases and their properties are diverse; they belong to different peptidase families and show differences in substrate specificity and biocatalytic potential. Bacterial aminoacylases capable of synthesis have been isolated from Burkholderia, Mycolicibacterium, and Streptomyces. Although several proteases and peptidases from S. griseus have been described, no aminoacylases from this species have been identified yet. In this study, we investigated two novel enzymes produced by S. griseus DSM 40236ᵀ . We identified and cloned the respective genes and recombinantly expressed an α-aminoacylase (EC 3.5.1.14), designated SgAA, and an ε-lysine acylase (EC 3.5.1.17), designated SgELA, in S. lividans TK23. The purified aminoacylase SgAA was biochemically characterized, focusing on its hydrolytic activity to determine temperature- and pH optima and stabilities. The aminoacylase could hydrolyze various acetyl-amino acids at the Nα -position with a broad specificity regarding the sidechain. Substrates with longer acyl chains, like lauroyl-amino acids, were hydrolyzed to a lesser extent. Purified aminoacylase SgELA specific for the hydrolysis of Nε -acetyl-L-lysine was unstable and lost its enzymatic activity upon storage for a longer period but could initially be characterized. The pH optimum of SgELA was pH 8.0. While synthesis of acyl-amino acids was not observed with SgELA, SgAA catalyzed the synthesis of lauroyl-methionine.},
  language  = {en}
}
@misc{HeringPasteurWollnyetal.2014,
  author    = {Hering, T. and Pasteur, A. and Wollny, S. and Ulber, Roland and Tippk{\"o}tter, Nils},
  title     = {Magnetische Separation von Gold-Nanopartikeln zur Glucons{\"a}ure-Produktion durch Hochgradient-Magnetseparation im Labormaßstab},
  series = {Chemie Ingenieur Technik},
  volume    = {86},
  journal   = {Chemie Ingenieur Technik},
  number    = {9},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {0009-286X},
  doi       = {10.1002/cite.201450265},
  pages     = {1501},
  year      = {2014},
  abstract  = {Bei der Verarbeitung nachwachsender Rohstoffe entsteht aus Cellulose oder St{\"a}rke u. a. das wichtige Produkt Glucose. Diese niedermolekulare Kohlenhydratquelle wird {\"u}blicherweise als Substrat f{\"u}r biotechnologische und chemische Synthesen verwendet. Ein wirtschaftlich interessantes Oxidationsprodukt der Glucose ist Glucons{\"a}ure, die beispielsweise als Lebensmittelzusatzstoff (E 574), in der Medizin und Metallindustrie Verwendung findet. Die Umsetzung des Monosaccharids zu Glucons{\"a}ure erfolgt entweder durch mikrobielle Fermentation oder der Oxidation an heterogenen Katalysatoren. Die Zielsetzung der Studie ist die Untersuchung der Glucoseoxidation an magnetisierbaren Gold-Nanopartikeln unter nachfolgender Bypass-Separation des Katalysators mittels einer neuen Mini-HGMS-Einheit (Hochgradient-Magnetseparation). Dieser Filtertyp erm{\"o}glicht die selektive Trennung magnetischer Partikel aus Suspensionen mit hohem Feststoffgehalt oder Viskosit{\"a}t. Erste Ergebnisse zeigen eine Beladungskapazit{\"a}t des selbstkonstruierten Mini-HGMS von 550 mg goldbeschichteter magnetisierbarer Nanopartikel. Die Oxidation erfolgt bei einem pH-Wertvon 9, bei 40 °C und mit 100 mM Glucose in einem begasten R{\"u}hrkesselreaktor. Das System soll zuk{\"u}nftig zum Katalysatorrecycling von hochviskosen und Feststoffbelasteten Produktstr{\"o}men aus Bioraffinerien eingesetzt werden.},
  language  = {de}
}
@misc{EngelBayerUlberetal.2018,
  author    = {Engel, M. and Bayer, H. and Ulber, Roland and Tippk{\"o}tter, Nils},
  title     = {Kommt es in Elektrofermentationen mit Clostridium acetobutylicum zu einer Eisenlimitierung?},
  series = {Chemie Ingenieur Technik},
  volume    = {90},
  journal   = {Chemie Ingenieur Technik},
  number    = {9},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {0009-286X},
  doi       = {10.1002/cite.201855047},
  pages     = {1154},
  year      = {2018},
  abstract  = {Das strikt anaerobe Bakterium Clostridium acetobutylicum bildet die L{\"o}semittel Aceton, Butanol und Ethanol (ABE-Fermentation). Im Fall einer Eisenlimitierung kommt es zus{\"a}tzlich zu einer Riboflavinsekretion (RF), was durch die gelbe F{\"a}rbung des Kultur{\"u}berstands erkennbar ist. In dieser Arbeit wurde beobachtet, dass w{\"a}hrend Elektrofermentationen mit C. acetobutylicum bei -600 mV eine gelbe F{\"a}rbung auftritt. Es wurde deshalb untersucht, ob eine Eisenlimitierung im bio-elektrochemischen System (BES) vorliegt. Hierzu wurden die Flavinspezien bei Kultivierungen in Medien mit einer Eisenlimitierung bzw. mit ausreichend Eisen in Serumflaschen sowie im BES mit und ohne angelegtem Potenzial verglichen. In den Serumflaschenversuchen wurden RF und Flavinadenindinukleotid (FAD)-Konzentrationen von ‡ 20 mg L⁻¹ sowie Flavinmononukleotid (FMN)-Konzentrationen von ca. 5 mg L⁻¹ detektiert. Bei ausreichender Eisenverf{\"u}gbarkeit hingegen wurden in den Serumflaschen fast keine Flavine sekretiert. Im BES bei -600 mV hingegen wurde auch in diesen Kultur{\"u}berst{\"a}nden FMN und FAD (1-5 mg L⁻¹ ),jedoch kein RF gemessen. Diese Ergebnisse zeigen, dass die Flavinbildung im BES mit angelegtem Potenzial nicht mit der Flavinbildung unter Eisenlimitierung in Serumflaschen korreliert. Andere Faktoren f{\"u}r eine m{\"o}gliche Flavinbildung werden aktuell n{\"a}her betrachtet.},
  language  = {de}
}
@article{RuppSchulzeKuperjans2018,
  author    = {Rupp, Matthias and Schulze, Sven and Kuperjans, Isabel},
  title     = {Comparative life cycle analysis of conventional and hybrid heavy-duty trucks},
  series = {World electric vehicle journal},
  volume    = {9},
  journal   = {World electric vehicle journal},
  number    = {2},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2032-6653},
  doi       = {10.3390/wevj9020033},
  pages     = {Article No. 33},
  year      = {2018},
  abstract  = {Heavy-duty trucks are one of the main contributors to greenhouse gas emissions in German traffic. Drivetrain electrification is an option to reduce tailpipe emissions by increasing energy conversion efficiency. To evaluate the vehicle's environmental impacts, it is necessary to consider the entire life cycle. In addition to the daily use, it is also necessary to include the impact of production and disposal. This study presents the comparative life cycle analysis of a parallel hybrid and a conventional heavy-duty truck in long-haul operation. Assuming a uniform vehicle glider, only the differing parts of both drivetrains are taken into account to calculate the environmental burdens of the production. The use phase is modeled by a backward simulation in MATLAB/Simulink considering a characteristic driving cycle. A break-even analysis is conducted to show at what mileage the larger CO2eq emissions due to the production of the electric drivetrain are compensated. The effect of parameter variation on the break-even mileage is investigated by a sensitivity analysis. The results of this analysis show the difference in CO2eq/t km is negative, indicating that the hybrid vehicle releases 4.34 g CO2eq/t km over a lifetime fewer emissions compared to the diesel truck. The break-even analysis also emphasizes the advantages of the electrified drivetrain, compensating the larger emissions generated during production after already a distance of 15,800 km (approx. 1.5 months of operation time). The intersection coordinates, distance, and CO2eq, strongly depend on fuel, emissions for battery production and the driving profile, which lead to nearly all parameter variations showing an increase in break-even distance.},
  language  = {en}
}
@article{KobFrauenrath2009,
  author    = {Kob, Malte and Frauenrath, Tobias},
  title     = {A system for parallel measurement of glottis opening and larynx position},
  series = {Biomedical Signal Processing and Control},
  volume    = {4},
  journal   = {Biomedical Signal Processing and Control},
  number    = {3},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1746-8108},
  doi       = {10.1016/j.bspc.2009.03.004},
  pages     = {221 -- 228},
  year      = {2009},
  abstract  = {The simultaneous assessment of glottal dynamics and larynx position can be beneficial for the diagnosis of disordered voice or speech production and swallowing. Up to now, methods either concentrate on assessment of the glottis opening using optical, acoustical or electrical (electroglottography, EGG) methods, or on visualisation of the larynx position using ultrasound, computer tomography or magnetic resonance imaging techniques. The method presented here makes use of a time-multiplex measurement approach of space-resolved transfer impedances through the larynx. The fast sequence of measurements allows a quasi simultaneous assessment of both larynx position and EGG signal using up to 32 transmit-receive signal paths. The system assesses the dynamic opening status of the glottis as well as the vertical and back/forward motion of the larynx. Two electrode-arrays are used for the measurement of the electrical transfer impedance through the neck in different directions. From the acquired data the global and individual conductivity is calculated as well as a 2D point spatial representation of the minimum impedance. The position information is shown together with classical EGG signals allowing a synchronous visual assessment of glottal area and larynx position. A first application to singing voice analysis is presented that indicate a high potential of the method for use as a non-invasive tool in the diagnosis of voice, speech, and swallowing disorders.},
  language  = {en}
}
@article{MuesgenanntKoersMcNeilRadchenkoetal.2023,
  author    = {Mues genannt Koers, Lucas and McNeil, S. W. and Radchenko, V. and Paulßen, Elisabeth and Hoehr, Cornelia},
  title     = {Production of Co-58m in a siphon-style liquid target on a medical cyclotron},
  volume    = {195},
  number    = {Art. 110734},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0969-8043},
  doi       = {10.1016/j.apradiso.2023.110734},
  year      = {2023},
  abstract  = {We present the production of 58mCo on a small, 13 MeV medical cyclotron utilizing a siphon style liquid target system. Different concentrated iron(III)-nitrate solutions of natural isotopic distribution were irradiated at varying initial pressures and subsequently separated by solid phase extraction chromatography. The radio cobalt (58m/gCo and 56Co) was successfully produced with saturation activities of (0.35 ± 0.03) MBq μA-1 for 58mCo with a separation recovery of (75 ± 2) \% of cobalt after one separation step utilizing LN-resin.},
  language  = {en}
}