@article{HoehnePulz2009, author = {H{\"o}hne, Tim and Pulz, Christian}, title = {Projekt Adaptive Logistik : Dienstleister f{\"u}r die Montage in der Auftragsfertigung}, series = {RFID-Innovationen in Produktion und Logistik - Eine Analyse zu Potenzialen des RFID-Einsatzes in Produktion und Logistik}, journal = {RFID-Innovationen in Produktion und Logistik - Eine Analyse zu Potenzialen des RFID-Einsatzes in Produktion und Logistik}, editor = {Isensee, Johannes}, issn = {1860-840X}, pages = {11 -- 19}, year = {2009}, language = {de} } @article{Wilke2017, author = {Wilke, Thomas}, title = {[Rezension zu:] Deutsch, Kristina: Jean Marot. Un graveur d'architecture {\`a} l'{\´e}poque de Louis XIV. (= Ars et Scientia; 12), Berlin; Boston 2015.}, series = {ArtHist.net}, journal = {ArtHist.net}, year = {2017}, language = {de} } @article{Wilke2015, author = {Wilke, Thomas}, title = {[Rezension zu: ] Yvonne Prinzessin von Cro{\"y}: Das H{\^o}tel de Galliffet (1784-1792). Pariser Baupraxis undAusstattungskunst am feudalen Privatbau des ausgehenden Ancien R{\´e}gime, Hildesheim: Olms 2014}, series = {Sehepunkte}, volume = {15}, journal = {Sehepunkte}, number = {9}, issn = {1618-6168}, year = {2015}, language = {de} } @article{Wilke2011, author = {Wilke, Thomas}, title = {[Rezension zu: ] Simone Meyder: "Mehr k{\"o}niglich als frei". Robert de Cotte und das Bauen in Straßburgnach 1681, M{\"u}nster: Waxmann 2010}, series = {Sehepunkte}, volume = {11}, journal = {Sehepunkte}, number = {2}, issn = {1618-6168}, year = {2011}, language = {de} } @article{Wilke2008, author = {Wilke, Thomas}, title = {[Rezension zu: ] Gundula Lang: B{\"u}rgerliche Privatg{\"a}rten in deutschen Landen um 1800. Fallstudien zu Gestalt, Nutzung und Bedeutung im Kontext des gesellschaftlichen Umbruchs, Worms: Wernersche Verlagsgesellschaft 2007}, series = {Sehepunkte}, volume = {8}, journal = {Sehepunkte}, number = {9}, issn = {1618-6168}, year = {2008}, language = {de} } @article{Wilke2012, author = {Wilke, Thomas}, title = {Architekturzeichnung als Instrument der Theoriebildung. Lineamenta vs. Portraicture - Architekturdarstellung zwischen Wissenschaft und {\"O}ffentlichkeit. Tagung des DFG-Netzwerks-Schnittstelle Bild in Zusammenarbeit mit dem Lehrstuhl f{\"u}r Kunstgeschichte der Universit{\"a}t Regensburg, 28.4.2012.}, series = {Kunstchronik}, volume = {65}, journal = {Kunstchronik}, number = {9/10}, publisher = {Fachverlag Hans Carl}, address = {N{\"u}rnberg}, issn = {0023-5474}, pages = {494 -- 499}, year = {2012}, language = {de} } @article{Wilke2006, author = {Wilke, Thomas}, title = {[Tagungsbericht zu:] Bourbon - Habsburg - Oranien 1700 (Marburg, 19. - 21.10.2006).}, series = {ArtHist.net}, journal = {ArtHist.net}, year = {2006}, language = {de} } @article{WilsonDickieSchreiteretal.2018, author = {Wilson, C. E. and Dickie, A. P. and Schreiter, K. and Wehr, R. and Wilson, E. M. and Bial, J. and Scheer, Nico and Wilson, I. D. and Riley, R. J.}, title = {The pharmacokinetics and metabolism of diclofenac in chimeric humanized and murinized FRG mice}, series = {Archives of Toxicology}, volume = {92}, journal = {Archives of Toxicology}, number = {6}, publisher = {Springer}, issn = {1432-0738}, doi = {10.1007/s00204-018-2212-1}, pages = {1953 -- 1967}, year = {2018}, abstract = {The pharmacokinetics of diclofenac were investigated following single oral doses of 10 mg/kg to chimeric liver humanized and murinized FRG and C57BL/6 mice. In addition, the metabolism and excretion were investigated in chimeric liver humanized and murinized FRG mice. Diclofenac reached maximum blood concentrations of 2.43 ± 0.9 µg/mL (n = 3) at 0.25 h post-dose with an AUCinf of 3.67 µg h/mL and an effective half-life of 0.86 h (n = 2). In the murinized animals, maximum blood concentrations were determined as 3.86 ± 2.31 µg/mL at 0.25 h post-dose with an AUCinf of 4.94 ± 2.93 µg h/mL and a half-life of 0.52 ± 0.03 h (n = 3). In C57BL/6J mice, mean peak blood concentrations of 2.31 ± 0.53 µg/mL were seen 0.25 h post-dose with a mean AUCinf of 2.10 ± 0.49 µg h/mL and a half-life of 0.51 ± 0.49 h (n = 3). Analysis of blood indicated only trace quantities of drug-related material in chimeric humanized and murinized FRG mice. Metabolic profiling of urine, bile and faecal extracts revealed a complex pattern of metabolites for both humanized and murinized animals with, in addition to unchanged parent drug, a variety of hydroxylated and conjugated metabolites detected. The profiles in humanized mice were different to those of both murinized and wild-type animals, e.g., a higher proportion of the dose was detected in the form of acyl glucuronide metabolites and much reduced amounts as taurine conjugates. Comparison of the metabolic profiles obtained from the present study with previously published data from C57BL/6J mice and humans revealed a greater, though not complete, match between chimeric humanized mice and humans, such that the liver humanized FRG model may represent a model for assessing the biotransformation of such compounds in humans.}, language = {en} } @article{JochimMenzel2018, author = {Jochim, Haldor E. and Menzel, Christoph J.}, title = {Die Trassenb{\"u}ndelung als Planungsmethode nachhaltiger Verkehrspolitik}, series = {Der Eisenbahningenieur : EI}, volume = {69}, journal = {Der Eisenbahningenieur : EI}, number = {11}, publisher = {DVV Media Group}, address = {Hamburg}, issn = {0013-2810}, pages = {26 -- 31}, year = {2018}, language = {de} } @article{RossPlummerRodeetal.2010, author = {Ross, Jillian and Plummer, Simon M. and Rode, Anja and Scheer, Nico and Bower, Conrad C. and Vogel, Ortwin and Henderson, Colin J. and Wolf, C. Roland and Elcombe, Clifford R.}, title = {Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo}, series = {Toxicological Sciences}, volume = {116}, journal = {Toxicological Sciences}, number = {2}, publisher = {Oxford University Press}, address = {Oxford}, issn = {1096-0929}, doi = {10.1093/toxsci/kfq118}, pages = {452 -- 466}, year = {2010}, abstract = {Mouse nongenotoxic hepatocarcinogens phenobarbital (PB) and chlordane induce hepatomegaly characterized by hypertrophy and hyperplasia. Increased cell proliferation is implicated in the mechanism of tumor induction. The relevance of these tumors to human health is unclear. The xenoreceptors, constitutive androstane receptors (CARs), and pregnane X receptor (PXR) play key roles in these processes. Novel "humanized" and knockout models for both receptors were developed to investigate potential species differences in hepatomegaly. The effects of PB (80 mg/kg/4 days) and chlordane (10 mg/kg/4 days) were investigated in double humanized PXR and CAR (huPXR/huCAR), double knockout PXR and CAR (PXRKO/CARKO), and wild-type (WT) C57BL/6J mice. In WT mice, both compounds caused increased liver weight, hepatocellular hypertrophy, and cell proliferation. Both compounds caused alterations to a number of cell cycle genes consistent with induction of cell proliferation in WT mice. However, these gene expression changes did not occur in PXRKO/CARKO or huPXR/huCAR mice. Liver hypertrophy without hyperplasia was demonstrated in the huPXR/huCAR animals in response to both compounds. Induction of the CAR and PXR target genes, Cyp2b10 and Cyp3a11, was observed in both WT and huPXR/huCAR mouse lines following treatment with PB or chlordane. In the PXRKO/CARKO mice, neither liver growth nor induction of Cyp2b10 and Cyp3a11 was seen following PB or chlordane treatment, indicating that these effects are CAR/PXR dependent. These data suggest that the human receptors are able to support the chemically induced hypertrophic responses but not the hyperplastic (cell proliferation) responses. At this time, we cannot be certain that hCAR and hPXR when expressed in the mouse can function exactly as the genes do when they are expressed in human cells. However, all parameters investigated to date suggest that much of their functionality is maintained.}, language = {en} }