@article{WeldenSeverinsPoghossianetal.2022,
  author    = {Welden, Melanie and Severins, Robin and Poghossian, Arshak and Wege, Christina and Bongaerts, Johannes and Siegert, Petra and Keusgen, Michael and Sch{\"o}ning, Michael Josef},
  title     = {Detection of acetoin and diacetyl by a tobacco mosaic virus-assisted field-effect biosensor},
  series = {Chemosensors},
  volume    = {10},
  journal   = {Chemosensors},
  number    = {6},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2227-9040},
  doi       = {10.3390/chemosensors10060218},
  pages     = {Artikel 218},
  year      = {2022},
  abstract  = {Acetoin and diacetyl have a major impact on the flavor of alcoholic beverages such as wine or beer. Therefore, their measurement is important during the fermentation process. Until now, gas chromatographic techniques have typically been applied; however, these require expensive laboratory equipment and trained staff, and do not allow for online monitoring. In this work, a capacitive electrolyte-insulator-semiconductor sensor modified with tobacco mosaic virus (TMV) particles as enzyme nanocarriers for the detection of acetoin and diacetyl is presented. The enzyme acetoin reductase from Alkalihalobacillus clausii DSM 8716ᵀ is immobilized via biotin-streptavidin affinity, binding to the surface of the TMV particles. The TMV-assisted biosensor is electrochemically characterized by means of leakage-current, capacitance-voltage, and constant capacitance measurements. In this paper, the novel biosensor is studied regarding its sensitivity and long-term stability in buffer solution. Moreover, the TMV-assisted capacitive field-effect sensor is applied for the detection of diacetyl for the first time. The measurement of acetoin and diacetyl with the same sensor setup is demonstrated. Finally, the successive detection of acetoin and diacetyl in buffer and in diluted beer is studied by tuning the sensitivity of the biosensor using the pH value of the measurement solution.},
  language  = {en}
}
@article{KarschuckKaulenPoghossianetal.2021,
  author    = {Karschuck, Tobias and Kaulen, Corinna and Poghossian, Arshak and Wagner, Patrick H. and Sch{\"o}ning, Michael Josef},
  title     = {Gold nanoparticle-modified capacitive field-effect sensors: Studying the surface density of nanoparticles and coupling of charged polyelectrolyte macromolecules},
  series = {Electrochemical Science Advances},
  volume    = {2},
  journal   = {Electrochemical Science Advances},
  number    = {5},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {0938-5193},
  doi       = {10.1002/elsa.202100179},
  pages     = {10 Seiten},
  year      = {2021},
  abstract  = {The coupling of ligand-stabilized gold nanoparticles with field-effect devices offers new possibilities for label-free biosensing. In this work, we study the immobilization of aminooctanethiol-stabilized gold nanoparticles (AuAOTs) on the silicon dioxide surface of a capacitive field-effect sensor. The terminal amino group of the AuAOT is well suited for the functionalization with biomolecules. The attachment of the positively-charged AuAOTs on a capacitive field-effect sensor was detected by direct electrical readout using capacitance-voltage and constant capacitance measurements. With a higher particle density on the sensor surface, the measured signal change was correspondingly more pronounced. The results demonstrate the ability of capacitive field-effect sensors for the non-destructive quantitative validation of nanoparticle immobilization. In addition, the electrostatic binding of the polyanion polystyrene sulfonate to the AuAOT-modified sensor surface was studied as a model system for the label-free detection of charged macromolecules. Most likely, this approach can be transferred to the label-free detection of other charged molecules such as enzymes or antibodies.},
  language  = {en}
}
@article{HagebeukerLangeRingbeck2004,
  author    = {Hagebeuker, Bianca and Lange, Robert and Ringbeck, Thorsten},
  title     = {Bildverarbeitung mit der dritten Dimension : wenn die Pixel auch Laufzeiten auswerten},
  series = {Sensor-Report : Sensorik, Messtechnik, Bildverarbeitung, Fabrikautomation. - 2004, H. 2},
  journal   = {Sensor-Report : Sensorik, Messtechnik, Bildverarbeitung, Fabrikautomation. - 2004, H. 2},
  publisher = {Rek \& Thomas},
  address   = {St. Gallen},
  issn      = {0179-9592},
  pages     = {11 -- 17},
  year      = {2004},
  language  = {de}
}
@article{UysalFiratCreutzetal.2022,
  author    = {Uysal, Karya and Firat, Ipek Serat and Creutz, Till and Aydin, Inci Cansu and Artmann, Gerhard and Teusch, Nicole and Temiz Artmann, Ayseg{\"u}l},
  title     = {A novel in vitro wound healing assay using free-standing, ultra-thin PDMS membranes},
  series = {membranes},
  volume    = {2023},
  journal   = {membranes},
  number    = {13(1)},
  publisher = {MDPI},
  address   = {Basel},
  doi       = {10.3390/membranes13010022},
  pages     = {Artikel 22},
  year      = {2022},
  abstract  = {Advances in polymer science have significantly increased polymer applications in life sciences. We report the use of free-standing, ultra-thin polydimethylsiloxane (PDMS) membranes, called CellDrum, as cell culture substrates for an in vitro wound model. Dermal fibroblast monolayers from 28- and 88-year-old donors were cultured on CellDrums. By using stainless steel balls, circular cell-free areas were created in the cell layer (wounding). Sinusoidal strain of 1 Hz, 5\% strain, was applied to membranes for 30 min in 4 sessions. The gap circumference and closure rate of un-stretched samples (controls) and stretched samples were monitored over 4 days to investigate the effects of donor age and mechanical strain on wound closure. A significant decrease in gap circumference and an increase in gap closure rate were observed in trained samples from younger donors and control samples from older donors. In contrast, a significant decrease in gap closure rate and an increase in wound circumference were observed in the trained samples from older donors. Through these results, we propose the model of a cell monolayer on stretchable CellDrums as a practical tool for wound healing research. The combination of biomechanical cell loading in conjunction with analyses such as gene/protein expression seems promising beyond the scope published here.},
  language  = {en}
}
@article{NokiharaBerndt1979,
  author    = {Nokihara, Kiyoshi and Berndt, Heinz},
  title     = {Darstellung von Bis(S-methoxycarbonylthio)-B-Kette des Rinderinsulins},
  series = {Hoppe-Seyler's Zeitschrift f{\"u}r physiologische Chemie},
  volume    = {360},
  journal   = {Hoppe-Seyler's Zeitschrift f{\"u}r physiologische Chemie},
  number    = {1},
  issn      = {1437-4315},
  doi       = {10.1515/bchm2.1979.360.1.773},
  pages     = {773 -- 776},
  year      = {1979},
  language  = {de}
}
@article{Wolf2012,
  author    = {Wolf, Martin R.},
  title     = {Von Security Awareness zum Secure Behaviour},
  series = {Hakin9 Extra - IT-Forensik},
  volume    = {2012},
  journal   = {Hakin9 Extra - IT-Forensik},
  number    = {5},
  publisher = {Software Wydawnictwo},
  address   = {Warszawa},
  issn      = {1733-7186},
  pages     = {18 -- 19},
  year      = {2012},
  abstract  = {Security Awareness ist derzeit ein viel diskutiertes Thema. Es reicht nicht, einfach nur ein paar technische Systeme (z.B. Firewalls) zu installieren, um ein angemessenes Schutzniveau zu erzielen. Neben einer guten Organisation von IT Security ist es auch notwendig, den Mitarbeiter einzubinden. Der vielzitierte "Faktor Mensch" ist derjenige, der die Technik korrekt anwenden muss und der durch falsches Verhalten technische und organisatorische Schutzmaßnahmen aushebeln kann. Deshalb reicht es nicht aus, wenn sich der Mitarbeiter der Gefahren bewusst ("aware") ist, er muss auch dementsprechend "sicher" handeln.},
  language  = {de}
}
@article{NaithaniKlostermeyerLangeetal.1971,
  author    = {Naithani, V. K and Klostermeyer, Henning and Lange, H. R. and [u.a.], and Berndt, Heinz and [u.a.],},
  title     = {Preparation of peptide derivatives for porcine proinsulin-synthesis},
  series = {Biological Chemistry},
  volume    = {352},
  journal   = {Biological Chemistry},
  number    = {1},
  publisher = {De Gruyter},
  issn      = {1437-4315},
  doi       = {10.1515/bchm2.1971.352.1.1},
  pages     = {2 -- 3},
  year      = {1971},
  language  = {en}
}
@article{FuchsRitz2011,
  author    = {Fuchs, Britta and Ritz, Thomas},
  title     = {Absatzkan{\"a}le kaum verkn{\"u}pft},
  series = {IT-Mittelstand : IT-Business im Mittelstand},
  volume    = {2011},
  journal   = {IT-Mittelstand : IT-Business im Mittelstand},
  number    = {9},
  publisher = {Medienhaus-Verlag},
  address   = {Bergisch-Gladbach},
  pages     = {16},
  year      = {2011},
  language  = {de}
}
@article{Fabo2013,
  author    = {Fabo, Sabine},
  title     = {Pepr{\"a}sentatives D{\"o}sen},
  series = {Idiopendent Lyfestile (Boxhorn ; 27)},
  journal   = {Idiopendent Lyfestile (Boxhorn ; 27)},
  editor    = {Mohr, Klaus},
  publisher = {FH},
  address   = {Aachen},
  issn      = {1864-2535},
  pages     = {134 -- 139},
  year      = {2013},
  language  = {de}
}
@article{RiglingElkinDobbertinetal.2012,
  author    = {Rigling, Andreas and Elkin, Ch{\´e} and Dobbertin, Matthias and Eilmann, Britta and Giuggiola, Arnaud and Wohlgemuth, Thomas and Bugmann, Harald},
  title     = {Wald und Klimawandel in der inneralpinen Trockenregion Visp},
  series = {Schweizerische Zeitschrift f{\"u}r Forstwesen},
  volume    = {163},
  journal   = {Schweizerische Zeitschrift f{\"u}r Forstwesen},
  number    = {12},
  publisher = {Schweizerischer Forstverein},
  address   = {Z{\"u}rich},
  issn      = {2235-1469 (Online)},
  doi       = {10.3188/szf.2012.0481},
  pages     = {481 -- 492},
  year      = {2012},
  abstract  = {Der Temperaturanstieg der vergangenen Jahrzehnte war in Gebirgsregionen besonders ausgepr{\"a}gt. Sollte sich dieser Temperaturtrend im 21. Jahrhundert fortsetzen, dann d{\"u}rf-ten sich auch die H{\"a}ufigkeit und Intensit{\"a}t von Niederschl{\"a}-gen und Trockenperioden ver{\"a}ndern, was die Waldwirtschaft vor grosse Herausforderungen stellen wird. Trockenheit ist ein entscheidender Faktor f{\"u}r die Wald{\"o}kosysteme der inner-alpinen T{\"a}ler, wo seit Jahren trockenheitsbedingtes Baum-sterben festgestellt wird. Der vorliegende Beitrag hat zum Ziel, die Sensitivit{\"a}t der verschiedenen Wald{\"o}kosysteme ge-gen{\"u}ber Klimawandel und alternative, teilweise extreme Bewirtschaftungsvarianten in der Region Visp zu testen. Me-thodische Ans{\"a}tze wie Monitoring, Feldexperimente und dy-namische Modellierung wurden kombiniert, und es wurden verschiedene {\"O}kosystemleistungen ber{\"u}cksichtigt, so Holz-produktion, Schutz vor Naturgefahren, Kohlenstoffspeiche-rung und Aspekte der Biodiversit{\"a}t. Die Resultate deuten da-rauf hin, dass auf den Trockenstandorten der Tieflagen die einheimischen Baumarten an ihre physiologischen Grenzen stossen und l{\"a}ngerfristig {\"u}ber alternative Baumarten nach-gedacht werden sollte. In den mittleren Lagen d{\"u}rften Tro-ckenheit und Schadinsekten wie die Borkenk{\"a}fer die zuk{\"u}nf-tige Waldentwicklung steuern. In den Hochlagen hingegen werden sich die W{\"a}lder ausdehnen und besser wachsen als heute. Alle untersuchten {\"O}kosystemleistungen werden ge-bietsweise starken Ver{\"a}nderungen unterworfen sein. Die dis-kutierten Bewirtschaftungsvarianten scheinen dazu geeignet, die Wasserverf{\"u}gbarkeit der Best{\"a}nde, haupts{\"a}chlich in tief-eren Lagen, zu erh{\"o}hen und dadurch die Widerstandskraft der B{\"a}ume gegen{\"u}ber Trockenperioden vor{\"u}bergehend zu st{\"a}rken. Es ist aber davon ausgehen, dass nur verh{\"a}ltnism{\"a}s-sig starke Eingriffe wesentliche Effekte erzielen k{\"o}nnen. Die Verkn{\"u}pfung von Umweltmonitoring, Feldexperimenten und Modellierung unter Miteinbezug von {\"O}kosystemleistungen ist vielversprechend, da sie eine differenzierte Absch{\"a}tzung des zuk{\"u}nftigen Landschaftswandels und seiner Effekte auf die Waldleistungen erm{\"o}glicht.},
  language  = {de}
}