@article{ScheerRossKapelyukhetal.2010,
  author    = {Scheer, Nico and Ross, Jillian and Kapelyukh, Yury and Rode, Anja and Wolf, C. Roland},
  title     = {In vivo responses of the human and murine pregnane X receptor to dexamethasone in mice},
  series = {Drug Metabolism and Disposition},
  volume    = {38},
  journal   = {Drug Metabolism and Disposition},
  number    = {7},
  publisher = {ASPET},
  address   = {Bethesda},
  issn      = {1521-009X},
  doi       = {10.1124/dmd.109.031872},
  pages     = {1046 -- 1053},
  year      = {2010},
  abstract  = {Dexamethasone (DEX) is a potent and widely used anti-inflammatory and immunosuppressant glucocorticoid. It can bind and activate the pregnane X receptor (PXR), which plays a critical role as xenobiotic sensor in mammals to induce the expression of many enzymes, including cytochromes P450 in the CYP3A family. This induction results in its own metabolism. We have used a series of transgenic mouse lines, including a novel, improved humanized PXR line, to compare the induction profile of PXR-regulated drug-metabolizing enzymes after DEX administration, as well as looking at hepatic responses to rifampicin (RIF). The new humanized PXR model has uncovered further intriguing differences between the human and mouse receptors in that RIF only induced Cyp2b10 in the new humanized model. DEX was found to be a much more potent inducer of Cyp3a proteins in wild-type mice than in mice humanized for PXR. To assess whether PXR is involved in the detoxification of DEX in the liver, we analyzed the consequences of high doses of the glucocorticoid on hepatotoxicity on different PXR genetic backgrounds. We also studied these effects in an additional mouse model in which functional mouse Cyp3a genes have been deleted. These strains exhibited different sensitivities to DEX, indicating a protective role of the PXR and CYP3A proteins against the hepatotoxicity of this compound.},
  language  = {en}
}
@book{Matcha2010,
  author    = {Matcha, Heike},
  title     = {Therme mit G{\"a}stehaus : Masterentwurf WS 2009/2010},
  publisher = {Technische Universit{\"a}t Darmstadt},
  address   = {Darmstadt},
  isbn      = {978-3-88536-115-2},
  pages     = {75 S. : {\"u}berw. Ill},
  year      = {2010},
  language  = {de}
}
@book{Matcha2010,
  author    = {Matcha, Heike},
  title     = {Konzerthaus in Stralsund : Masterentwurf SS 2009},
  publisher = {Technische Universit{\"a}t Darmstadt},
  address   = {Darmstadt},
  isbn      = {978-3-88536-114-5},
  pages     = {83 S. : {\"u}berw. Ill.},
  year      = {2010},
  language  = {de}
}
@book{Matcha2010,
  author    = {Matcha, Heike},
  title     = {Lamborghini an der Spree : Masterentwurf WS 2008/2009},
  publisher = {Technische Universit{\"a}t Darmstadt},
  address   = {Darmstadt},
  isbn      = {978-3-88536-113-8},
  pages     = {65 S. : {\"u}berw. Ill.},
  year      = {2010},
  language  = {de}
}
@book{MatchaQuastenRabighomi2010,
  author    = {Matcha, Heike and Quasten, Gero and Rabighomi, Hossein},
  title     = {Qualit{\"a}tssteigerung im verdichteten Wohnungsbau {\"u}ber Erzeugung gr{\"o}ßerer Vielfalt und Flexibilit{\"a}t durch individualisierte Massenfertigung am Beispiel gestapelter Reihenh{\"a}user},
  publisher = {Fraunhofer IRB Verlag},
  address   = {Stuttgart},
  isbn      = {978-3-8167-8216-2},
  pages     = {171 S. : graph. Darst.},
  year      = {2010},
  language  = {de}
}
@incollection{Matcha2010,
  author    = {Matcha, Heike},
  title     = {Regelbasierte Planung - Parametrik},
  series = {Digitale Prozesse: Planung, Gestaltung, Fertigung},
  booktitle = {Digitale Prozesse: Planung, Gestaltung, Fertigung},
  editor    = {Hauschild, Moritz and Karzel, R{\"u}diger},
  publisher = {Ed. Detail},
  address   = {M{\"u}nchen},
  isbn      = {978-3-920034-35-5},
  pages     = {24 -- 24},
  year      = {2010},
  language  = {de}
}
@incollection{Matcha2010,
  author    = {Matcha, Heike},
  title     = {Regelbasierte Planung - Parametrik},
  series = {Digitale Prozesse : Planung, Gestaltung, Fertigung},
  booktitle = {Digitale Prozesse : Planung, Gestaltung, Fertigung},
  editor    = {Hauschild, Moritz and Karzel, R{\"u}diger},
  publisher = {Detail},
  address   = {M{\"u}nchen},
  isbn      = {978-3-95553-022-8},
  doi       = {10.11129/detail.9783955530228},
  pages     = {24 -- 24},
  year      = {2010},
  language  = {de}
}
@book{Matcha2010,
  author    = {Matcha, Heike},
  title     = {Expo 15 : Experimental Parametric Object ; Realisierung des Messestandes "Digital Origami" f{\"u}r den Fachbereich Architektur der Technischen Universit{\"a}t Darmstadt},
  publisher = {Technische Universit{\"a}t Darmstadt},
  address   = {Darmstadt},
  pages     = {54 S. : Ill.},
  year      = {2010},
  language  = {de}
}
@inproceedings{MatchaLjubas2010,
  author    = {Matcha, Heike and Ljubas, Ante},
  title     = {Parametric Origami: Adaptable temporary buildings},
  series = {Future cities: 28th eCAADe Conference Proceedings. eCAADe: Conferences. Zurich, Switzerland},
  booktitle = {Future cities: 28th eCAADe Conference Proceedings. eCAADe: Conferences. Zurich, Switzerland},
  isbn      = {978-0-9541183-7-2},
  pages     = {243 -- 251},
  year      = {2010},
  language  = {en}
}
@techreport{TemizArtmann2010,
  author    = {Temiz Artmann, Ayseg{\"u}l},
  title     = {Fr{\"u}hgeburtenrate mindern durch ein Prognoseverfahren f{\"u}r den vorzeitigen Blasensprung - PROMPT (Premature rupture of membranes prediction test) : Abschlussbericht ; Laufzeit des Vorhabens: 01.03.2007 - 31.12.2009},
  publisher = {Technische Informationsbibliothek u. Universit{\"a}tsbibliothek},
  address   = {Aachen},
  doi       = {10.2314/GBV:644277858},
  year      = {2010},
  language  = {de}
}