@article{SchlamannVoigtMaderwaldetal.2010, author = {Schlamann, Marc and Voigt, Melanie A. and Maderwald, Stefan and Bitz, Andreas and Kraff, Oliver and Ladd, Susanne C. and Ladd, Mark E. and Forsting, Michael and Wilhelm, Hans}, title = {Exposure to high-field MRI does not affect cognitive function}, series = {Journal of Magnetic Resonance Imaging}, volume = {31}, journal = {Journal of Magnetic Resonance Imaging}, number = {5}, publisher = {Wiley-Liss}, address = {New York}, issn = {1522-2586}, doi = {10.1002/jmri.22065}, pages = {1061 -- 1066}, year = {2010}, abstract = {Purpose To assess potential cognitive deficits under the influence of static magnetic fields at various field strengths some studies already exist. These studies were not focused on attention as the most vulnerable cognitive function. Additionally, mostly no magnetic resonance imaging (MRI) sequences were performed. Materials and Methods In all, 25 right-handed men were enrolled in this study. All subjects underwent one MRI examination of 63 minutes at 1.5 T and one at 7 T within an interval of 10 to 30 days. The order of the examinations was randomized. Subjects were referred to six standardized neuropsychological tests strictly focused on attention immediately before and after each MRI examination. Differences in neuropsychological variables between the timepoints before and after each MRI examination were assessed and P-values were calculated Results Only six subtests revealed significant differences between pre- and post-MRI. In these tests the subjects achieved better results in post-MRI testing than in pre-MRI testing (P = 0.013-0.032). The other tests revealed no significant results. Conclusion The improvement in post-MRI testing is only explicable as a result of learning effects. MRI examinations, even in ultrahigh-field scanners, do not seem to have any persisting influence on the attention networks of human cognition immediately after exposure.}, language = {en} } @article{SchlamannYoonMaderwaldetal.2010, author = {Schlamann, Marc and Yoon, Min-Suk and Maderwald, Stefan and Pietrzyk, Thomas and Bitz, Andreas and Gerwig, Marcus and Forsting, Michael and Ladd, Susanne C. and Ladd, Mark E. and Kastrup, Oliver}, title = {Short term effects of magnetic resonance imaging on excitability of the motor cortex at 1.5T and 7T}, series = {Academic Radiology}, volume = {17}, journal = {Academic Radiology}, number = {3}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1076-6332}, doi = {10.1016/j.acra.2009.10.004}, pages = {277 -- 281}, year = {2010}, abstract = {Rationale and Objectives The increasing spread of high-field and ultra-high-field magnetic resonance imaging (MRI) scanners has encouraged new discussion of the safety aspects of MRI. Few studies have been published on possible cognitive effects of MRI examinations. The aim of this study was to examine whether changes are measurable after MRI examinations at 1.5 and 7 T by means of transcranial magnetic stimulation (TMS). Materials and Methods TMS was performed in 12 healthy, right-handed male volunteers. First the individual motor threshold was specified, and then the cortical silent period (SP) was measured. Subsequently, the volunteers were exposed to the 1.5-T MRI scanner for 63 minutes using standard sequences. The MRI examination was immediately followed by another TMS session. Fifteen minutes later, TMS was repeated. Four weeks later, the complete setting was repeated using a 7-T scanner. Control conditions included lying in the 1.5-T scanner for 63 minutes without scanning and lying in a separate room for 63 minutes. TMS was performed in the same way in each case. For statistical analysis, Wilcoxon's rank test was performed. Results Immediately after MRI exposure, the SP was highly significantly prolonged in all 12 subjects at 1.5 and 7 T. The motor threshold was significantly increased. Fifteen minutes after the examination, the measured value tended toward normal again. Control conditions revealed no significant differences. Conclusion MRI examinations lead to a transient and highly significant alteration in cortical excitability. This effect does not seem to depend on the strength of the static magnetic field.}, language = {en} } @inproceedings{AbelBoninAlbrachtetal.2010, author = {Abel, Thomas and Bonin, Dominik and Albracht, Kirsten and Zeller, Sebastian and Br{\"u}ggemann, Gert-Peter and Burkett, Brendan and Str{\"u}der, Heiko K.}, title = {Kinematic profile of the elite handcyclist}, series = {28th International Conference on Biomechanics in Sports, Marquette, Michigan, USA, July 19 - 23, 2010}, booktitle = {28th International Conference on Biomechanics in Sports, Marquette, Michigan, USA, July 19 - 23, 2010}, issn = {1999-4168}, pages = {140 -- 141}, year = {2010}, language = {en} } @phdthesis{Albracht2010, author = {Albracht, Kirsten}, title = {Influence of mechanical properties of the leg extensor muscletendon units on running economy}, publisher = {Deutsche Sporthochschule K{\"o}ln}, address = {K{\"o}ln}, pages = {X, 1221 Bl. : graph. Darst.}, year = {2010}, language = {en} } @article{KrollLudwigs2010, author = {Kroll-Ludwigs, Kathrin}, title = {Die Zukunft des verbrauchersch{\"u}tzenden Widerrufsrechts in Europa}, series = {Zeitschrift f{\"u}r europ{\"a}isches Privatrecht : ZEuP}, volume = {18}, journal = {Zeitschrift f{\"u}r europ{\"a}isches Privatrecht : ZEuP}, number = {3}, publisher = {Beck}, address = {M{\"u}nchen}, issn = {0943-3929}, pages = {509 -- 534}, year = {2010}, abstract = {Das verbrauchersch{\"u}tzende Widerrufsrecht ist in die Jahre gekommen. Als Ergebnis der zunehmenden Rechtszersplitterung im europ{\"a}ischen Richtlinienrecht hat sich eine un{\"u}berschaubare Bandbreite an Ausgestaltungsformen in den mitgliedstaatlichen Rechtssystemen herausgebildet. Effektivit{\"a}tseinbußen, Wettbewerbsverzerrungen und ein hohes Maß an Rechtsunsicherheit sind die Folgen. Zur{\"u}ckf{\"u}hren l{\"a}sst sich die kostenintensive Fragmentierung des Verbrauchervertragsrechts auf die bisherige Regelungspolitik der Mindestharmonisierung, die es den Mitgliedstaaten erlaubt, von dem durch die Richtlinien gesetzten Mindeststandard durch „{\"u}berschießende Umsetzung" abzuweichen. Der Unionsgesetzgeber versucht dem vermehrt durch einen Prozess der Vollharmonisierung zu begegnen: Neben Reformen der Richtlinie {\"u}ber Verbraucherkredite (VerbrKrRL) sowie der Timesharing-Richtlinie (TimesharingRL), liegt seit dem 8. Oktober 2008 nunmehr auch der Entwurf einer Rahmenrichtlinie {\"u}ber die Rechte der Verbraucher (VRRL-E) vor. Danach sollen die bisherigen Richtlinien {\"u}ber Haust{\"u}rgesch{\"a}fte (Haust{\"u}rgesch{\"a}fteRL), Fernabsatzvertr{\"a}ge (FARL), missbr{\"a}uchliche Klauseln sowie Verbrauchsg{\"u}terk{\"a}ufe vereinigt werden. F{\"u}r das verbrauchersch{\"u}tzende Widerrufsrecht ist damit zum einen die Herausbildung einheitlicher Kernelemente verbunden, zum anderen tritt es in Konkurrenz zu umfassenden Informationspflichten, die ebenfalls den Schutz des Verbrauchers vor dem un{\"u}berlegten Abschluss riskanter bzw. nachteiliger Vertr{\"a}ge zum Ziel haben. Angesichts dieser Entwicklung stellt sich im Folgenden die Frage nach der Zukunft des unionsrechtlichen Widerrufsrechts. Von besonderer Bedeutung ist dabei die Kl{\"a}rung des Verh{\"a}ltnisses zu den verbrauchersch{\"u}tzenden Informationspflichten. Dazu bedarf es zun{\"a}chst der Herausarbeitung einheitlicher Kernelemente des Widerrufsrechts im vollharmonisierten Richtlinienrecht (II.) sowie einer Systematisierung der sekund{\"a}rrechtlichen Informationspflichten im Anschluss eine kritische Gegen{\"u}berstellung der Vor- und Nachteile beider Schutzinstrumente erfolgen kann (IV.).}, language = {de} } @article{NabilPetersonSchmidtetal.2010, author = {Nabil, F. and Peterson, Leif Arne and Schmidt, A. and Geerdes, D.}, title = {Die Holzkuppel des Neuen Palais in Potsdam}, series = {Bauingenieur}, volume = {85}, journal = {Bauingenieur}, number = {8}, publisher = {Springer-VDI-Verlag}, address = {D{\"u}sseldorf}, issn = {0005-6650}, pages = {324 -- 330}, year = {2010}, language = {de} } @article{DegeringEggertPulsetal.2010, author = {Degering, Christian and Eggert, Thorsten and Puls, Michael and Bongaerts, Johannes and Evers, Stefan and Maurer, Karl-Heinz and Jaeger, Karl-Erich}, title = {Optimization of protease secretion in Bacillus subtilis and Bacillus licheniformis by screening of homologous and herologous signal peptides}, series = {Applied and environmental microbiology}, volume = {76}, journal = {Applied and environmental microbiology}, number = {19}, publisher = {American Society for Microbiology}, address = {Washington, DC}, issn = {1098-5336 (E-Journal); 0003-6919 (Print); 0099-2240 (Print)}, doi = {10.1128/AEM.01146-10}, pages = {6370 -- 6378}, year = {2010}, abstract = {Bacillus subtilis and Bacillus licheniformis are widely used for the large-scale industrial production of proteins. These strains can efficiently secrete proteins into the culture medium using the general secretion (Sec) pathway. A characteristic feature of all secreted proteins is their N-terminal signal peptides, which are recognized by the secretion machinery. Here, we have studied the production of an industrially important secreted protease, namely, subtilisin BPN′ from Bacillus amyloliquefaciens. One hundred seventy-three signal peptides originating from B. subtilis and 220 signal peptides from the B. licheniformis type strain were fused to this secretion target and expressed in B. subtilis, and the resulting library was analyzed by high-throughput screening for extracellular proteolytic activity. We have identified a number of signal peptides originating from both organisms which produced significantly increased yield of the secreted protease. Interestingly, we observed that levels of extracellular protease were improved not only in B. subtilis, which was used as the screening host, but also in two different B. licheniformis strains. To date, it is impossible to predict which signal peptide will result in better secretion and thus an improved yield of a given extracellular target protein. Our data show that screening a library consisting of homologous and heterologous signal peptides fused to a target protein can identify more-effective signal peptides, resulting in improved protein export not only in the original screening host but also in different production strains.}, language = {en} } @incollection{ReimerBraunWellmeretal.2010, author = {Reimer, Lars and Braun, Carsten and Wellmer, Georg and Behr, Marek and Ballmann, Josef}, title = {Development of a modular method for computational aero-structural analysis of aircraft}, series = {Summary of flow modulation and fluid-structure interaction findings. Results of the Collaborative Research Center SFB 401 at the RWTH Aachen University, Aachen, Germany, 1997-2008 / ed.: Wolfgang Schr{\"o}der. Notes on numerical fluid mechanics and multidisciplinary design. Vol. 109}, booktitle = {Summary of flow modulation and fluid-structure interaction findings. Results of the Collaborative Research Center SFB 401 at the RWTH Aachen University, Aachen, Germany, 1997-2008 / ed.: Wolfgang Schr{\"o}der. Notes on numerical fluid mechanics and multidisciplinary design. Vol. 109}, publisher = {Springer}, address = {Berlin}, isbn = {978-3-642-04087-0}, pages = {205 -- 238}, year = {2010}, language = {en} } @inproceedings{ElsenHawariJohnen2010, author = {Elsen, Ingo and Hawari, Asma and Johnen, Uwe}, title = {Produktkernel in der Systemintegration (Erfahrungsbericht aus der Praxis)}, series = {Vom Projekt zum Produkt - Fachtagung des GI-Fachausschusses Management der Anwendungsentwicklung und -wartung im Fachbereich Wirtschaftsinformatik (WI-MAW), 1. - 3. Dezember 2010 in Aachen}, booktitle = {Vom Projekt zum Produkt - Fachtagung des GI-Fachausschusses Management der Anwendungsentwicklung und -wartung im Fachbereich Wirtschaftsinformatik (WI-MAW), 1. - 3. Dezember 2010 in Aachen}, editor = {Pietsch, Wolfram and Krams, Benedikt}, publisher = {Gesellschaft f{\"u}r Informatik eV}, address = {Bonn}, isbn = {9783885792727}, issn = {1617-5468}, pages = {93 -- 102}, year = {2010}, abstract = {In der Vergangenheit basierten große Systemintegrationsprojekte in der Regel auf Individualentwicklungen f{\"u}r einzelne Kunden. Getrieben durch Kostendruck steigt aber der Bedarf nach standardisierten L{\"o}sungen, die gleichzeitig die individuellen Anforderungen des jeweiligen Umfelds ber{\"u}cksichtigen. T-Systems GEI GmbH wird beiden Anforderungen mit Produktkerneln gerecht. Neben den technischen Aspekten der Kernelentwicklung spielen besonders organisatorische Aspekte eine Rolle, um Kernel effizient und qualitativ hochwertig zu entwickeln, ohne deren Funktionalit{\"a}ten ins Uferlose wachsen zu lassen. Umgesetzt hat T-Systems dieses Konzept f{\"u}r Flughafeninformationssysteme. Damit kann dem wachsenden Bedarf der Flughafenbetreiber nach einer effizienten und kosteng{\"u}nstigen Softwarel{\"o}sung zur Unterst{\"u}tzung Ihrer Gesch{\"a}ftsprozesse entsprochen werden.}, language = {de} } @inproceedings{ParkButenwegReindl2010, author = {Park, Jin and Butenweg, Christoph and Reindl, Lukas}, title = {Untersuchung der Eignung von Ankerschienensystemen unter Erdbebeneinwirkungen}, series = {Conference proceedings / ANSYS Conference \& 28th CADFEM Users´ Meeting 2010 : 3. - 5. November 2010, Eurogess Aachen / CADFEM; ANSYS}, booktitle = {Conference proceedings / ANSYS Conference \& 28th CADFEM Users´ Meeting 2010 : 3. - 5. November 2010, Eurogess Aachen / CADFEM; ANSYS}, publisher = {CADFEM [u.a.]}, address = {Grafing}, isbn = {3-937523-07-3}, pages = {Dokument 2.11.1}, year = {2010}, language = {de} }