@article{SchifferFerreinLakemeyer2011, author = {Schiffer, Stefan and Ferrein, Alexander and Lakemeyer, Gerhard}, title = {Reasoning with Qualitative Positional Information for Domestic Domains in the Situation Calculus}, series = {Journal of Intelligent \& Robotic Systems}, volume = {63}, journal = {Journal of Intelligent \& Robotic Systems}, number = {2}, publisher = {Springer}, address = {Berlin}, isbn = {0921-0296}, pages = {273 -- 300}, year = {2011}, language = {en} } @article{MourzinaMaiPoghossianetal.2003, author = {Mourzina, Y. and Mai, T. and Poghossian, Arshak and Ermolenko, Y. and Yoshinobu, T. and Vlasov, Y. and Iwasaki, H. and Sch{\"o}ning, Michael Josef}, title = {K+-selective field-effect sensors as transducers for bioelectronic applications}, series = {Electrochimica Acta. 48 (2003), H. 20-22}, journal = {Electrochimica Acta. 48 (2003), H. 20-22}, isbn = {0013-4686}, pages = {3333 -- 3339}, year = {2003}, language = {en} } @article{PoghossianPlatenSchoening2005, author = {Poghossian, Arshak and Platen, J. and Sch{\"o}ning, Michael Josef}, title = {Towards self-aligned nanostructures by means of layerexpansion technique}, series = {Electrochimica Acta. 51 (2005), H. 5}, journal = {Electrochimica Acta. 51 (2005), H. 5}, isbn = {0013-4686}, pages = {838 -- 843}, year = {2005}, language = {en} } @article{Weigand1991, author = {Weigand, Christoph}, title = {A Solution to the Scheduling Problem Taking into Account Quality}, series = {Operations research '91 : extended abstracts of the 16th Symposium on Operations Research held at the University of Trier at September 9 - 11, 1991 / [GM{\"O}OR]. Peter Gritzmann ... (eds.)}, journal = {Operations research '91 : extended abstracts of the 16th Symposium on Operations Research held at the University of Trier at September 9 - 11, 1991 / [GM{\"O}OR]. Peter Gritzmann ... (eds.)}, publisher = {Physica-Verl.}, address = {Heidelberg}, isbn = {3790806080}, pages = {373 -- 375}, year = {1991}, language = {en} } @article{BronderPoghossianSchejaetal.2015, author = {Bronder, Thomas and Poghossian, Arshak and Scheja, Sabrina and Wu, Chunsheng and Keusgen, Michael and Mewes, Dieter and Sch{\"o}ning, Michael Josef}, title = {DNA Immobilization and Hybridization Detection by the Intrinsic Molecular Charge Using Capacitive Field-Effect Sensors Modified with a Charged Weak Polyelectrolyte Layer}, series = {Applied Materials \& Interfaces}, volume = {36}, journal = {Applied Materials \& Interfaces}, number = {7}, publisher = {American Chemical Society}, address = {Washington, DC}, doi = {10.1021/acsami.5b05146}, pages = {20068 -- 20075}, year = {2015}, abstract = {Miniaturized setup, compatibility with advanced micro- and nanotechnologies, and ability to detect biomolecules by their intrinsic molecular charge favor the semiconductor field-effect platform as one of the most attractive approaches for the development of label-free DNA chips. In this work, a capacitive field-effect EIS (electrolyte-insulator-semiconductor) sensor covered with a layer-by-layer prepared, positively charged weak polyelectrolyte layer of PAH (poly(allylamine hydrochloride)) was used for the label-free electrical detection of DNA (deoxyribonucleic acid) immobilization and hybridization. The negatively charged probe single-stranded DNA (ssDNA) molecules were electrostatically adsorbed onto the positively charged PAH layer, resulting in a preferentially flat orientation of the ssDNA molecules within the Debye length, thus yielding a reduced charge-screening effect and a higher sensor signal. Each sensor-surface modification step (PAH adsorption, probe ssDNA immobilization, hybridization with complementary target DNA (cDNA), reducing an unspecific adsorption by a blocking agent, incubation with noncomplementary DNA (ncDNA) solution) was monitored by means of capacitance-voltage and constant-capacitance measurements. In addition, the surface morphology of the PAH layer was studied by atomic force microscopy and contact-angle measurements. High hybridization signals of 34 and 43 mV were recorded in low-ionic strength solutions of 10 and 1 mM, respectively. In contrast, a small signal of 4 mV was recorded in the case of unspecific adsorption of fully mismatched ncDNA. The density of probe ssDNA and dsDNA molecules as well as the hybridization efficiency was estimated using the experimentally measured DNA immobilization and hybridization signals and a simplified double-layer capacitor model. The results of field-effect experiments were supported by fluorescence measurements, verifying the DNA-immobilization and hybridization event.}, language = {en} } @article{BaeckerRaueSchusseretal.2012, author = {B{\"a}cker, Matthias and Raue, Markus and Schusser, Sebastian and Jeitner, C. and Breuer, L. and Wagner, P. and Poghossian, Arshak and F{\"o}rster, Arnold and Mang, Thomas and Sch{\"o}ning, Michael Josef}, title = {Microfluidic chip with integrated microvalves based on temperature- and pH-responsive hydrogel thin films}, series = {Physica Status Solidi (a)}, volume = {209}, journal = {Physica Status Solidi (a)}, number = {5}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.201100763}, pages = {839 -- 845}, year = {2012}, abstract = {Two types of microvalves based on temperature-responsive poly(N-isopropylacrylamide) (PNIPAAm) and pH-responsive poly(sodium acrylate) (PSA) hydrogel films have been developed and tested. The PNIPAAm and PSA hydrogel films were prepared by means of in situ photopolymerization directly inside the fluidic channel of a microfluidic chip fabricated by combining Si and SU-8 technologies. The swelling/shrinking properties and height changes of the PNIPAAm and PSA films inside the fluidic channel were studied at temperatures of deionized water from 14 to 36 °C and different pH values (pH 3-12) of Titrisol buffer, respectively. Additionally, in separate experiments, the lower critical solution temperature (LCST) of the PNIPAAm hydrogel was investigated by means of a differential scanning calorimetry (DSC) and a surface plasmon resonance (SPR) method. Mass-flow measurements have shown the feasibility of the prepared hydrogel films to work as an on-chip integrated temperature- or pH-responsive microvalve capable to switch the flow channel on/off.}, language = {en} } @article{BronderPoghossianKeusgenetal.2017, author = {Bronder, Thomas and Poghossian, Arshak and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Label-free detection of double-stranded DNA molecules with polyelectrolyte-modified capacitive field-effect sensors}, series = {tm - Technisches Messen}, volume = {84}, journal = {tm - Technisches Messen}, number = {10}, publisher = {De Gruyter}, address = {Oldenbourg}, doi = {10.1515/teme-2017-0015}, pages = {628 -- 634}, year = {2017}, abstract = {In this study, polyelectrolyte-modified field-effect-based electrolyte-insulator-semiconductor (EIS) devices have been used for the label-free electrical detection of double-stranded deoxyribonucleic acid (dsDNA)molecules. The sensor-chip functionalization with a positively charged polyelectrolyte layer provides the possibility of direct adsorptive binding of negatively charged target DNA oligonucleotides onto theSiO2-chip surface.EIS sensors can be utilized as a tool to detect surface-charge changes; the electrostatic adsorption of oligonucleotides onto the polyelectrolyte layer leads to a measureable surface-potential change. Signals of 39mV have been recorded after the incubation with the oligonucleotide solution. Besides the electrochemical experiments, the successful adsorption of dsDNA onto the polyelectrolyte layer has been verified via fluorescence microscopy. The presented results demonstrate that the signal recording of EISchips, which are modified with a polyelectrolyte layer, canbe used as a favorable approach for a fast, cheap and simple detection method for dsDNA.}, language = {en} } @article{JablonskiPoghossianSeverinetal.2021, author = {Jablonski, Melanie and Poghossian, Arshak and Severin, Robin and Keusgen, Michael and Wege, Christian and Sch{\"o}ning, Michael Josef}, title = {Capacitive Field-Effect Biosensor Studying Adsorption of Tobacco Mosaic Virus Particles}, series = {Micromachines}, volume = {12}, journal = {Micromachines}, number = {1}, publisher = {MDPI}, address = {Basel}, doi = {10.3390/mi12010057}, pages = {Artikel 57}, year = {2021}, abstract = {Plant virus-like particles, and in particular, tobacco mosaic virus (TMV) particles, are increasingly being used in nano- and biotechnology as well as for biochemical sensing purposes as nanoscaffolds for the high-density immobilization of receptor molecules. The sensitive parameters of TMV-assisted biosensors depend, among others, on the density of adsorbed TMV particles on the sensor surface, which is affected by both the adsorption conditions and surface properties of the sensor. In this work, Ta₂O₅-gate field-effect capacitive sensors have been applied for the label-free electrical detection of TMV adsorption. The impact of the TMV concentration on both the sensor signal and the density of TMV particles adsorbed onto the Ta₂O₅-gate surface has been studied systematically by means of field-effect and scanning electron microscopy methods. In addition, the surface density of TMV particles loaded under different incubation times has been investigated. Finally, the field-effect sensor also demonstrates the label-free detection of penicillinase immobilization as model bioreceptor on TMV particles.}, language = {en} } @article{ValeroBung2016, author = {Valero, Daniel and Bung, Daniel Bernhard}, title = {Sensitivity of turbulent Schmidt number and turbulence model to simulations of jets in crossflow}, series = {Environmental Modelling and Software}, volume = {82}, journal = {Environmental Modelling and Software}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1364-8152 (electronic)}, doi = {10.1016/j.envsoft.2016.04.030}, pages = {218 -- 228}, year = {2016}, abstract = {Environmental discharges have been traditionally designed by means of cost-intensive and time-consuming experimental studies. Some extensively validated models based on an integral approach have been often employed for water quality problems, as recommended by USEPA (i.e.: CORMIX). In this study, FLOW-3D is employed for a full 3D RANS modelling of two turbulent jet-to-crossflow cases, including free surface jet impingement. Results are compared to both physical modelling and CORMIX to better assess model performance. Turbulence measurements have been collected for a better understanding of turbulent diffusion's parameter sensitivity. Although both studied models are generally able to reproduce jet trajectory, jet separation downstream of the impingement has been reproduced only by RANS modelling. Additionally, concentrations are better reproduced by FLOW-3D when the proper turbulent Schmidt number is used. This study provides a recommendation on the selection of the turbulence model and the turbulent Schmidt number for future outfall structures design studies.}, language = {en} } @article{KurulganDemirciDemirciTrzewiketal.2011, author = {Kurulgan Demirci, Eylem and Demirci, T. and Trzewik, J{\"u}rgen and Linder, Peter and Karakulah, G. and Artmann, Gerhard and Sakizli, M. and Temiz Artmann, Ayseg{\"u}l}, title = {Genome-Wide Gene Expression Analysis of NIH 3T3 Cell Line Under Mechanical Stimulation}, series = {Cellular and molecular bioengineering. 4 (2011), H. 1}, journal = {Cellular and molecular bioengineering. 4 (2011), H. 1}, publisher = {Springer}, address = {Berlin}, isbn = {1865-5025}, pages = {46 -- 55}, year = {2011}, language = {en} } @article{SchoeningAbouzarPoghossian2009, author = {Sch{\"o}ning, Michael Josef and Abouzar, Maryam H. and Poghossian, Arshak}, title = {pH and ion sensitivity of a field-effect EIS (electrolyte-insulator-semiconductor) sensor covered with polyelectrolyte multilayers}, series = {Journal of Solid State Electrochemistry. 13 (2009), H. 1}, journal = {Journal of Solid State Electrochemistry. 13 (2009), H. 1}, isbn = {1433-0768}, pages = {115 -- 122}, year = {2009}, language = {en} } @article{ThustPoghossianSchoeningetal.1999, author = {Thust, M. and Poghossian, Arshak and Sch{\"o}ning, Michael Josef and Naser, S. and M{\"u}ller-Veggian, Mattea and Kordos, P. and L{\"u}th, H.}, title = {Cross-sensitivity of a capacitive penicillin sensor combined with a diffusion barrier}, series = {Proceedings : The Hague, The Netherlands, September 12 - 15, 1999 / [ed. by M. Bartek]. - Vol 1.}, journal = {Proceedings : The Hague, The Netherlands, September 12 - 15, 1999 / [ed. by M. Bartek]. - Vol 1.}, address = {The Hague, The Netherlands}, isbn = {90-76699-02-X}, pages = {573 -- 576}, year = {1999}, language = {en} } @article{SchoeningPoghossianYoshinobuetal.2001, author = {Sch{\"o}ning, Michael Josef and Poghossian, Arshak and Yoshinobu, Tatsuo and L{\"u}th, Hans}, title = {Semiconductor-based field-effect structures for chemical sensing}, pages = {188 -- 198}, year = {2001}, language = {en} } @article{KochPoghossianSchoeningetal.2018, author = {Koch, Claudia and Poghossian, Arshak and Sch{\"o}ning, Michael Josef and Wege, Christian}, title = {Penicillin Detection by Tobacco Mosaic Virus-Assisted Colorimetric Biosensors}, series = {Nanotheranostics}, volume = {2}, journal = {Nanotheranostics}, number = {2}, publisher = {Ivyspring}, address = {Sydney}, issn = {2206-7418}, doi = {10.7150/ntno.22114}, pages = {184 -- 196}, year = {2018}, abstract = {The presentation of enzymes on viral scaffolds has beneficial effects such as an increased enzyme loading and a prolonged reusability in comparison to conventional immobilization platforms. Here, we used modified tobacco mosaic virus (TMV) nanorods as enzyme carriers in penicillin G detection for the first time. Penicillinase enzymes were conjugated with streptavidin and coupled to TMV rods by use of a bifunctional biotin-linker. Penicillinase-decorated TMV particles were characterized extensively in halochromic dye-based biosensing. Acidometric analyte detection was performed with bromcresol purple as pH indicator and spectrophotometry. The TMV-assisted sensors exhibited increased enzyme loading and strongly improved reusability, and higher analysis rates compared to layouts without viral adapters. They extended the half-life of the sensors from 4 - 6 days to 5 weeks and thus allowed an at least 8-fold longer use of the sensors. Using a commercial budget-priced penicillinase preparation, a detection limit of 100 µM penicillin was obtained. Initial experiments also indicate that the system may be transferred to label-free detection layouts.}, language = {en} } @article{HarzheimMuehmelHeuermann2021, author = {Harzheim, Thomas and M{\"u}hmel, Marc and Heuermann, Holger}, title = {A SFCW harmonic radar system for maritime search and rescue using passive and active tags}, series = {International Journal of Microwave and Wireless Technologies}, volume = {13}, journal = {International Journal of Microwave and Wireless Technologies}, number = {Special Issue 7}, publisher = {Cambridge University Press}, address = {Cambridge}, doi = {10.1017/S1759078721000520}, pages = {691 -- 707}, year = {2021}, abstract = {This paper introduces a new maritime search and rescue system based on S-band illumination harmonic radar (HR). Passive and active tags have been developed and tested while attached to life jackets and a small boat. In this demonstration test carried out on the Baltic Sea, the system was able to detect and range the active tags up to a distance of 5800 m using an illumination signal transmit-power of 100 W. Special attention is given to the development, performance, and conceptual differences between passive and active tags used in the system. Guidelines for achieving a high HR dynamic range, including a system components description, are given and a comparison with other HR systems is performed. System integration with a commercial maritime X-band navigation radar is shown to demonstrate a solution for rapid search and rescue response and quick localization.}, language = {en} } @article{PoghossianThustSchoeningetal.2000, author = {Poghossian, Arshak and Thust, M. and Sch{\"o}ning, Michael Josef and M{\"u}ller-Veggian, Mattea and Kordos, P. and L{\"u}th, H.}, title = {Cross-sensitivity of a capacitive penicillin sensor combined with a diffusion barrier}, series = {Sensors and Actuators B. 68 (2000), H. 1-3}, journal = {Sensors and Actuators B. 68 (2000), H. 1-3}, isbn = {0925-4005}, pages = {260 -- 265}, year = {2000}, language = {en} } @article{SchoeningBrinkmannDemuthetal.2004, author = {Sch{\"o}ning, Michael Josef and Brinkmann, D. and Demuth, C. and Poghossian, Arshak}, title = {CIP (cleaning-in-place)-suitable „non-glass" pH sensor based on a Ta2O5-gate EIS structure}, series = {Digest of technical papers : September 12 - 15, 2004, Rome, Italy, Pontificia Universitas Sancto Thoma Aquinate in Urbe / [conference chairperson: C. Di Natale].}, journal = {Digest of technical papers : September 12 - 15, 2004, Rome, Italy, Pontificia Universitas Sancto Thoma Aquinate in Urbe / [conference chairperson: C. Di Natale].}, address = {Roma}, isbn = {88-7621-282-5}, pages = {857 -- 860}, year = {2004}, language = {en} } @article{PoghossianBerndsenLuethetal.2001, author = {Poghossian, Arshak and Berndsen, Lars and L{\"u}th, Hans and Sch{\"o}ning, Michael Josef}, title = {Novel concepts for flow-rate and flow-direction determination by means of pH-sensitive ISFETs}, series = {Proceedings of SPIE. 4560 (2001)}, journal = {Proceedings of SPIE. 4560 (2001)}, pages = {19 -- 27}, year = {2001}, language = {en} } @article{Staat1993, author = {Staat, Manfred}, title = {Sensitivity of and Influences on the Reliability of an HTR-Module Primary Circuit Pressure Boundary}, series = {Transactions of the 12th International Conference on Structural Mechanics in Reactor Technology (SMiRT-12) / Kussmaul, K. [ed]}, journal = {Transactions of the 12th International Conference on Structural Mechanics in Reactor Technology (SMiRT-12) / Kussmaul, K. [ed]}, publisher = {Elsevier}, address = {Amsterdam}, isbn = {0-444-81515-5}, pages = {147 -- 152}, year = {1993}, language = {en} } @article{Stulpe2020, author = {Stulpe, Werner}, title = {Pairwise coexistence of effects versus coexistence}, series = {Journal of Physics: Conference Series}, volume = {1638}, journal = {Journal of Physics: Conference Series}, number = {012004}, publisher = {IOP}, address = {Bristol}, issn = {1742-6596}, doi = {10.1088/1742-6596/1638/1/012004}, pages = {1 -- 21}, year = {2020}, language = {en} } @article{HonarvarfardGamellaPoghossianetal.2017, author = {Honarvarfard, Elham and Gamella, Maria and Poghossian, Arshak and Sch{\"o}ning, Michael Josef and Katz, Evgeny}, title = {An enzyme-based reversible Controlled NOT (CNOT) logic gate operating on a semiconductor transducer}, series = {Applied Materials Today}, volume = {9}, journal = {Applied Materials Today}, publisher = {Elsevier}, address = {Amsterdam}, issn = {2352-9407}, doi = {10.1016/j.apmt.2017.08.003}, pages = {266 -- 270}, year = {2017}, abstract = {An enzyme-based biocatalytic system mimicking operation of a logically reversible Controlled NOT (CNOT) gate has been interfaced with semiconductor electronic transducers. Electrolyte-insulator-semiconductor (EIS) structures have been used to transduce chemical changes produced by the enzyme system to an electronically readable capacitive output signal using field-effect features of the EIS device. Two enzymes, urease and esterase, were immobilized on the insulating interface of EIS structure producing local pH changes performing XOR logic operation controlled by various combinations of the input signals represented by urea and ethyl butyrate. Another EIS transducer was functionalized with esterase only, thus performing Identity (ID) logic operation for the ethyl butyrate input. Both semiconductor devices assembled in parallel operated as a logically reversible CNOT gate. The present system, despite its simplicity, demonstrated for the first time logically reversible function of the enzyme system transduced electronically with the semiconductor devices. The biomolecular realization of a CNOT gate interfaced with semiconductors is promising for integration into complex biomolecular networks and future biosensor/biomedical applications.}, language = {en} } @article{YoshinobuEckenPoghossianetal.2001, author = {Yoshinobu, T. and Ecken, H. and Poghossian, Arshak and Simonis, A. and Iwasaki, H. and L{\"u}th, H. and Sch{\"o}ning, Michael Josef}, title = {Constant-current-mode LAPS (CLAPS) for the detection of penicillin}, series = {Electroanalysis. 13 (2001), H. 8-9}, journal = {Electroanalysis. 13 (2001), H. 8-9}, isbn = {1040-0397}, pages = {733 -- 736}, year = {2001}, language = {en} } @article{PoghossianAbouzarSchoening2008, author = {Poghossian, Arshak and Abouzar, Maryam H. and Sch{\"o}ning, Michael Josef}, title = {Capacitance-voltage and impedance characteristics of field-effect EIS sensors functionalised with polyelectrolyte multilayers}, series = {IRBM. 29 (2008), H. 2-3}, journal = {IRBM. 29 (2008), H. 2-3}, isbn = {1959-0318}, pages = {149 -- 154}, year = {2008}, language = {en} } @article{PoghossianLuethSchultzeetal.2001, author = {Poghossian, Arshak and L{\"u}th, H. and Schultze, J. W. and Sch{\"o}ning, Michael Josef}, title = {(Bio-)chemical and physical microsensor array using an identical transducer principle}, series = {Scaling down in electrochemistry : electrochemical micro- and nanosystem technology ; proceedings of the 3rd International Symposium on Electrochemical Microsystem Technologies, Garmisch-Patenkirchen, Germany, 11 - 15 September 2000 / ed. by J. W. Schultz}, journal = {Scaling down in electrochemistry : electrochemical micro- and nanosystem technology ; proceedings of the 3rd International Symposium on Electrochemical Microsystem Technologies, Garmisch-Patenkirchen, Germany, 11 - 15 September 2000 / ed. by J. W. Schultz}, publisher = {Elsevier [u.a.]}, address = {Amsterdam [u.a.]}, isbn = {0-08-044014-2}, pages = {243 -- 249}, year = {2001}, language = {en} } @article{SchoeningPoghossian2006, author = {Sch{\"o}ning, Michael Josef and Poghossian, Arshak}, title = {BioFEDs (field-effect devices) : State-of-the-art and new directions}, series = {Electroanalysis}, volume = {18}, journal = {Electroanalysis}, number = {19-20}, issn = {1521-4109}, doi = {10.1002/elan.200603609}, pages = {1893 -- 1900}, year = {2006}, language = {en} } @article{HuckPoghossianKerroumietal.2014, author = {Huck, Christina and Poghossian, Arshak and Kerroumi, Iman and Schusser, Sebastian and B{\"a}cker, Matthias and Zander, Willi and Schubert, J{\"u}rgen and Buniatyan, Vahe V. and Martirosyan, Norayr W. and Wagner, Patrick and Sch{\"o}ning, Michael Josef}, title = {Multiparameter sensor chip with Barium Strontium Titanate as multipurpose material}, series = {Electroanalysis}, volume = {26}, journal = {Electroanalysis}, number = {5}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1521-4109 (E-Journal); 1040-0397 (Print)}, doi = {10.1002/elan.201400076}, pages = {980 -- 987}, year = {2014}, abstract = {It is well known that biochemical and biotechnological processes are strongly dependent and affected by a variety of physico-chemical parameters such as pH value, temperature, pressure and electrolyte conductivity. Therefore, these quantities have to be monitored or controlled in order to guarantee a stable process operation, optimization and high yield. In this work, a sensor chip for the multiparameter detection of three physico-chemical parameters such as electrolyte conductivity, pH and temperature is realized using barium strontium titanate (BST) as multipurpose material. The chip integrates a capacitively coupled four-electrode electrolyte-conductivity sensor, a capacitive field-effect pH sensor and a thin-film Pt-temperature sensor. Due to the multifunctional properties of BST, it is utilized as final outermost coating layer of the processed sensor chip and serves as passivation and protection layer as well as pH-sensitive transducer material at the same time. The results of testing of the individual sensors of the developed multiparameter sensor chip are presented. In addition, a quasi-simultaneous multiparameter characterization of the sensor chip in buffer solutions with different pH value and electrolyte conductivity is performed. To study the sensor behavior and the suitability of BST as multifunctional material under harsh environmental conditions, the sensor chip was exemplarily tested in a biogas digestate.}, language = {en} } @article{RolkaPoghossianSchoening2004, author = {Rolka, David and Poghossian, Arshak and Sch{\"o}ning, Michael Josef}, title = {Integration of a capacitive EIS sensor into a FIA system for pH and penicillin determination}, series = {Sensors. 4 (2004)}, journal = {Sensors. 4 (2004)}, isbn = {1424-8220}, pages = {84 -- 94}, year = {2004}, language = {en} } @article{PoghossianSchoening2004, author = {Poghossian, Arshak and Sch{\"o}ning, Michael Josef}, title = {Detecting Both Physical and (Bio-)Chemical Parameters by Means of ISFET Devices}, series = {Electroanalysis. 16 (2004), H. 22}, journal = {Electroanalysis. 16 (2004), H. 22}, isbn = {1040-0397}, pages = {1863 -- 1872}, year = {2004}, language = {en} } @article{SchifferFerreinLakemeyer2012, author = {Schiffer, Stefan and Ferrein, Alexander and Lakemeyer, Gerhard}, title = {Caesar: an intelligent domestic service robot}, series = {Intelligent service robotics}, volume = {5}, journal = {Intelligent service robotics}, number = {4}, publisher = {Springer}, address = {Berlin}, issn = {1861-2776}, doi = {10.1007/s11370-012-0118-y}, pages = {259 -- 276}, year = {2012}, abstract = {In this paper we present CAESAR, an intelligent domestic service robot. In domestic settings for service robots complex tasks have to be accomplished. Those tasks benefit from deliberation, from robust action execution and from flexible methods for human-robot interaction that account for qualitative notions used in natural language as well as human fallibility. Our robot CAESAR deploys AI techniques on several levels of its system architecture. On the low-level side, system modules for localization or navigation make, for instance, use of path-planning methods, heuristic search, and Bayesian filters. For face recognition and human-machine interaction, random trees and well-known methods from natural language processing are deployed. For deliberation, we use the robot programming and plan language READYLOG, which was developed for the high-level control of agents and robots; it allows combining programming the behaviour using planning to find a course of action. READYLOG is a variant of the robot programming language Golog. We extended READYLOG to be able to cope with qualitative notions of space frequently used by humans, such as "near" and "far". This facilitates human-robot interaction by bridging the gap between human natural language and the numerical values needed by the robot. Further, we use READYLOG to increase the flexible interpretation of human commands with decision-theoretic planning. We give an overview of the different methods deployed in CAESAR and show the applicability of a system equipped with these AI techniques in domestic service robotics}, language = {en} } @article{SiqueiraAbouzarPoghossianetal.2009, author = {Siqueira, Jos{\´e} R. Jr. and Abouzar, Maryam H. and Poghossian, Arshak and Zucolotto, Valtencir and Oliveira, Osvaldo N. Jr. and Sch{\"o}ning, Michael Josef}, title = {Penicillin biosensor based on a capacitive field-effect structure functionalized with a dendrimer/carbon nanotube multilayer}, series = {Biosensors and Bioelectronics. 25 (2009), H. 2}, journal = {Biosensors and Bioelectronics. 25 (2009), H. 2}, isbn = {0956-5663}, pages = {497 -- 501}, year = {2009}, language = {en} } @article{Fabo1993, author = {Fabo, Sabine}, title = {Arts and media : towards an universal understanding}, series = {Leonardo}, volume = {26(1993)}, journal = {Leonardo}, number = {4}, issn = {0024-094X}, pages = {316 -- 319}, year = {1993}, language = {en} } @article{GamellaZakharchenkoGuzetal.2017, author = {Gamella, Maria and Zakharchenko, Andrey and Guz, Nataliia and Masi, Madeline and Minko, Sergiy and Kolpashchikov, Dmitry M. and Iken, Heiko and Poghossian, Arshak and Sch{\"o}ning, Michael Josef and Katz, Evgeny}, title = {DNA computing system activated by electrochemically triggered DNA realease from a polymer-brush-modified electrode array}, series = {Electroanalysis}, volume = {29}, journal = {Electroanalysis}, number = {2}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1521-4109}, doi = {10.1002/elan.201600389}, pages = {398 -- 408}, year = {2017}, abstract = {An array of four independently wired indium tin oxide (ITO) electrodes was used for electrochemically stimulated DNA release and activation of DNA-based Identity, AND and XOR logic gates. Single-stranded DNA molecules were loaded on the mixed poly(N,N-dimethylaminoethyl methacrylate) (PDMAEMA)/poly(methacrylic acid) (PMAA) brush covalently attached to the ITO electrodes. The DNA deposition was performed at pH 5.0 when the polymer brush is positively charged due to protonation of tertiary amino groups in PDMAEMA, thus resulting in electrostatic attraction of the negatively charged DNA. By applying electrolysis at -1.0 V(vs. Ag/AgCl reference) electrochemical oxygen reduction resulted in the consumption of hydrogen ions and local pH increase near the electrode surface. The process resulted in recharging the polymer brush to the negative state due to dissociation of carboxylic groups of PMAA, thus repulsing the negatively charged DNA and releasing it from the electrode surface. The DNA release was performed in various combinations from different electrodes in the array assembly. The released DNA operated as input signals for activation of the Boolean logic gates. The developed system represents a step forward in DNA computing, combining for the first time DNA chemical processes with electronic input signals.}, language = {en} } @article{AbouzarPoghossianRazavietal.2008, author = {Abouzar, Maryam H. and Poghossian, Arshak and Razavi, Arash and Besmehn, Astrid and Bijnens, Nathalie and Williams, Oliver A. and Haenen, Ken and Wagner, Patrick and Sch{\"o}ning, Michael Josef}, title = {Penicillin detection with nanocrystalline-diamond field-effect sensor}, series = {physica status solidi (a). 205 (2008), H. 9}, journal = {physica status solidi (a). 205 (2008), H. 9}, isbn = {1862-6319}, pages = {2141 -- 2145}, year = {2008}, language = {en} } @article{GossmannThomasHorvathetal.2020, author = {Gossmann, Matthias and Thomas, Ulrich and Horv{\´a}th, Andr{\´a}s and Dragicevic, Elena and Stoelzle-Feix, Sonja and Jung, Alexander and Raman, Aravind Hariharan and Staat, Manfred and Linder, Peter}, title = {A higher-throughput approach to investigate cardiac contractility in vitro under physiological mechanical conditions}, series = {Journal of Pharmacological and Toxicological Methods}, volume = {105}, journal = {Journal of Pharmacological and Toxicological Methods}, number = {Article 106843}, publisher = {Elsevier}, address = {New York, NY}, doi = {10.1016/j.vascn.2020.106843}, year = {2020}, language = {en} } @article{FerreinSchifferLakemeyer2009, author = {Ferrein, Alexander and Schiffer, Stefan and Lakemeyer, Gerhard}, title = {Embedding fuzzy controllers in golog / Ferrein, Alexander ; Schiffer, Stefan ; Lakemeyer, Gerhard}, series = {IEEE International Conference on Fuzzy Systems, 2009. FUZZ-IEEE 2009}, journal = {IEEE International Conference on Fuzzy Systems, 2009. FUZZ-IEEE 2009}, publisher = {IEEE}, address = {New York}, isbn = {978-1-4244-3596-8}, pages = {894 -- 899}, year = {2009}, language = {en} } @article{AbouzarIngebrandtPoghossianetal.2009, author = {Abouzar, Maryam H. and Ingebrandt, S. and Poghossian, Arshak and Zhang, Y. and Moritz, W. and Sch{\"o}ning, Michael Josef}, title = {Field-effect nanoplate capacitive pH sensor based on SOI structure}, series = {Semiconductor micro- and nanoelectronics : Proceedings of the Seventh International Conference , Tsakhcadzor, Armenia July 3-5 2009}, journal = {Semiconductor micro- and nanoelectronics : Proceedings of the Seventh International Conference , Tsakhcadzor, Armenia July 3-5 2009}, pages = {55 -- 58}, year = {2009}, language = {en} } @article{PoghossianSchoening2003, author = {Poghossian, Arshak and Sch{\"o}ning, Michael Josef}, title = {"High-order" hybrid FET module for (bio)chemical and physical sensing}, series = {Integrated analytical systems / ed. by Salvador Alegret}, journal = {Integrated analytical systems / ed. by Salvador Alegret}, publisher = {Elsevier}, address = {Amsterdam [u.a.]}, isbn = {0-444-51037-0}, pages = {587 -- 623}, year = {2003}, language = {en} } @article{WuBronderPoghossianetal.2015, author = {Wu, Chunsheng and Bronder, Thomas and Poghossian, Arshak and Werner, Frederik and Sch{\"o}ning, Michael Josef}, title = {Label-free detection of DNA using light-addressable potentiometric sensor modified with a positively charged polyelectrolyte layer}, series = {Nanoscale}, volume = {14}, journal = {Nanoscale}, number = {7}, publisher = {Royal Society of Chemistry (RSC)}, address = {Cambridge}, doi = {10.1039/C4NR07225A}, pages = {6143 -- 6150}, year = {2015}, abstract = {A multi-spot (16 spots) light-addressable potentiometric sensor (MLAPS) consisting of an Al-p-Si-SiO2 structure modified with a weak polyelectrolyte layer of PAH (poly(allylamine hydrochloride)) was applied for the label-free electrical detection of DNA (deoxyribonucleic acid) immobilization and hybridization by the intrinsic molecular charge for the first time. To achieve a preferentially flat orientation of DNA strands and thus, to reduce the distance between the DNA charge and MLAPS surface, the negatively charged probe single-stranded DNAs (ssDNA) were electrostatically adsorbed onto the positively charged PAH layer using a simple layer-by-layer (LbL) technique. In this way, more DNA charge can be positioned within the Debye length, yielding a higher sensor signal. The surface potential changes in each spot induced due to the surface modification steps (PAH adsorption, probe ssDNA immobilization, hybridization with complementary target DNA (cDNA), non-specific adsorption of mismatched ssDNA) were determined from the shifts of photocurrent-voltage curves along the voltage axis. A high sensor signal of 83 mV was registered after immobilization of probe ssDNA onto the PAH layer. The hybridization signal increases from 5 mV to 32 mV with increasing the concentration of cDNA from 0.1 nM to 5 μM. In contrast, a small signal of 5 mV was recorded in the case of non-specific adsorption of fully mismatched ssDNA (5 μM). The obtained results demonstrate the potential of the MLAPS in combination with the simple and rapid LbL immobilization technique as a promising platform for the future development of multi-spot light-addressable label-free DNA chips with direct electrical readout.}, language = {en} } @article{BeckerDelfmannEggertetal.2012, author = {Becker, J{\"o}rg and Delfmann, Patrick and Eggert, Mathias and Schwittay, Sebastian}, title = {Generalizability and Applicability of Model-Based Business Process Compliance-Checking Approaches — A State-of-the-Art Analysis and Research Roadmap}, series = {Business Research : BuR}, volume = {5}, journal = {Business Research : BuR}, number = {2}, publisher = {Springer}, address = {Heidelberg}, issn = {1866-8658}, doi = {10.1007/BF03342739}, pages = {221 -- 247}, year = {2012}, abstract = {With a steady increase of regulatory requirements for business processes, automation support of compliance management is a field garnering increasing attention in Information Systems research. Several approaches have been developed to support compliance checking of process models. One major challenge for such approaches is their ability to handle different modeling techniques and compliance rules in order to enable widespread adoption and application. Applying a structured literature search strategy, we reflect and discuss compliance-checking approaches in order to provide an insight into their generalizability and evaluation. The results imply that current approaches mainly focus on special modeling techniques and/or a restricted set of types of compliance rules. Most approaches abstain from real-world evaluation which raises the question of their practical applicability. Referring to the search results, we propose a roadmap for further research in model-based business process compliance checking.}, language = {en} } @article{BegingMlynekHataihimakuletal.2010, author = {Beging, Stefan and Mlynek, Daniela and Hataihimakul, Sudkanung and Poghossian, Arshak and Baldsiefen, Gerhard and Busch, Heinz and Laube, Norbert and Kleinen, Lisa and Sch{\"o}ning, Michael Josef}, title = {Field-effect calcium sensor for the determination of the risk of urinary stone formation}, series = {Sensors and Actuators B: Chemical. 144 (2010), H. 2}, journal = {Sensors and Actuators B: Chemical. 144 (2010), H. 2}, pages = {374 -- 379}, year = {2010}, language = {en} } @article{HeuermannRumiantsevSchott2004, author = {Heuermann, Holger and Rumiantsev, A. and Schott, S.}, title = {Advanced on-wafer multiport calibration methods for mono- and mixed-mode device characterization}, series = {On wafer characterization : 63rd ARFTG conference digest, spring 2004, 11 June 2004, Fort Worth, TX / Automatic RF Techniques Group. [Conference chair: John Cable. Publication chair: J. G. Burns]}, journal = {On wafer characterization : 63rd ARFTG conference digest, spring 2004, 11 June 2004, Fort Worth, TX / Automatic RF Techniques Group. [Conference chair: John Cable. Publication chair: J. G. Burns]}, publisher = {IEEE Operations Center}, address = {Piscataway, NJ}, isbn = {0-7803-8371-0}, pages = {91 -- 96}, year = {2004}, language = {en} } @article{HacklMuellerStaatetal.2016, author = {Hackl, Michael and M{\"u}ller, Lars-Peter and Staat, Manfred and Kahmann, Stephanie Lucina and Wegmann, Kilian}, title = {Proximal phalangeal neck fractures of the hand — a biomechanical comparison of three fixation techniques}, series = {Knee surgery, sports traumatology, arthroscopy}, volume = {Volume 24}, journal = {Knee surgery, sports traumatology, arthroscopy}, number = {Supplement 1}, publisher = {Springer}, address = {Berlin}, issn = {0942-2056}, doi = {10.1007/s00167-016-4080-7}, pages = {148 -- 149}, year = {2016}, abstract = {Plate osteosynthesis of displaced proximal phalangeal neck fractures of the hand allows early mobilization due to a stable internal fixation. Nevertheless, joint stiffness—because of soft tissue irritation—represents a common complication leading to high complication rates. Del Pinal et al. recently reported promising clinical results for a new, minimally invasive fixation technique with a cannulated headless intramedullary compression screw. Hence, the aim of this study was to compare plate fixation of proximal phalangeal neck fractures to less two less invasive techniques: Crossed k-wire fixation and intramedullary screw fixation. We hypothesized that these fixation techniques provide inferior stability when compared to plate osteosynthesis.}, language = {en} } @article{BuniatyanHuckPoghossianetal.2013, author = {Buniatyan, V. and Huck, Christina and Poghossian, Arshak and Aroutiounian, V. M. and Sch{\"o}ning, Michael Josef}, title = {BaxSr1-x TiO3/pc-Si heterojunction}, series = {Armenian journal of physics}, volume = {6}, journal = {Armenian journal of physics}, number = {4}, publisher = {National Academy of Sciences of Armenia}, address = {Yerevan}, issn = {1829-1171}, pages = {177 -- 187}, year = {2013}, language = {en} } @article{YoshinobuEckenPoghossianetal.2001, author = {Yoshinobu, T. and Ecken, H. and Poghossian, Arshak and L{\"u}th, H. and Iwasaki, H. and Sch{\"o}ning, Michael Josef}, title = {Alternative sensor materials for light-addressable potentiometric sensors}, series = {Sensors and Actuators B. 76 (2001), H. 1-3}, journal = {Sensors and Actuators B. 76 (2001), H. 1-3}, isbn = {0925-4005}, pages = {388 -- 392}, year = {2001}, language = {en} } @article{HeuermannErkens2004, author = {Heuermann, Holger and Erkens, Holger}, title = {Blocking structures for mixed-mode systems. / Erkens, Holger ; Heuermann, Holger}, series = {Conference proceedings : Tuesday 12th, Wednesday 13th and Thursday 14th October, [RAI International Exhibition and Congress Centre, Amsterdam ; part of European Microwave Week 2004] / EuMA, European Microwave Association. Vol. 1}, journal = {Conference proceedings : Tuesday 12th, Wednesday 13th and Thursday 14th October, [RAI International Exhibition and Congress Centre, Amsterdam ; part of European Microwave Week 2004] / EuMA, European Microwave Association. Vol. 1}, publisher = {Horizon House Publ.}, address = {London}, isbn = {1-580-53992-0}, pages = {297 -- 300}, year = {2004}, language = {en} } @article{PoghossianAbouzarSakkarietal.2006, author = {Poghossian, Arshak and Abouzar, Maryam H. and Sakkari, M. and Kassab, T. and Han, Y. and Ingebrandt, S. and Offenh{\"a}usser, A. and Sch{\"o}ning, Michael Josef}, title = {Field-effect sensors for monitoring the layer-by-layer adsorption of charged macromolecules}, series = {Sensors and Actuators B: Chemical. 118 (2006), H. 1-2}, journal = {Sensors and Actuators B: Chemical. 118 (2006), H. 1-2}, isbn = {0925-4005}, pages = {163 -- 170}, year = {2006}, language = {en} } @article{LinderBecklerDoerretal.2019, author = {Linder, Peter and Beckler, Matthias and Doerr, Leo and Stoelzle-Feix, Sonja and Fertig, Niels and Jung, Alexander and Staat, Manfred and Gossmann, Matthias}, title = {A new in vitro tool to investigate cardiac contractility under physiological mechanical conditions}, series = {Journal of Pharmacological and Toxicological Methods}, volume = {99}, journal = {Journal of Pharmacological and Toxicological Methods}, number = {Article number 106595}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1056-8719}, doi = {10.1016/j.vascn.2019.05.162}, year = {2019}, language = {en} } @article{LinderDigelTemizArtmannetal.2007, author = {Linder, Peter and Digel, Ilya and Temiz Artmann, Ayseg{\"u}l and Kayser, Peter and Porst, Dariusz and Artmann, Gerhard}, title = {High-throughput testing of mechanical forces generated in thin cell and tissue layers}, series = {Tissue Engineering. 13 (2007), H. 7}, journal = {Tissue Engineering. 13 (2007), H. 7}, isbn = {1076-3279}, pages = {1778 -- 1778}, year = {2007}, language = {en} } @article{HeuermannSchiek1992, author = {Heuermann, Holger and Schiek, Burkhard}, title = {A Fast and Robust Procedure for the Determination of the Scattering Parameters for Network Analyzer Calibration}, address = {Paris}, pages = {373 -- 374}, year = {1992}, language = {en} } @article{KraemerPitaZhouetal.2009, author = {Kr{\"a}mer, Melina and Pita, Marcos and Zhou, Jian and Ornatska, Maryna and Poghossian, Arshak and Sch{\"o}ning, Michael Josef and Katz, Evgeny}, title = {Coupling of Biocomputing Systems with Electronic Chips: Electronic Interface for Transduction of Biochemical Information}, series = {Journal of Physical Chemistry C: Nanomaterials and Interfaces. 113 (2009), H. 6}, journal = {Journal of Physical Chemistry C: Nanomaterials and Interfaces. 113 (2009), H. 6}, publisher = {American Cemical Society}, address = {Washington, DC}, isbn = {1932-7455}, pages = {2573 -- 2579}, year = {2009}, language = {en} } @article{HuckJollyWagneretal.2011, author = {Huck, Christina and Jolly, Christina and Wagner, Patrick and Poghossian, Arshak and Sch{\"o}ning, Michael Josef}, title = {One-chip integrated dual amperometric/field-effect sensor for the detection of dissolved hydrogen}, series = {Procedia Engineering. 25 (2011)}, journal = {Procedia Engineering. 25 (2011)}, publisher = {Elsevier}, address = {Amsterdam}, isbn = {1877-7058}, pages = {1161 -- 1164}, year = {2011}, language = {en} } @article{WuBronderPoghossianetal.2014, author = {Wu, Chunsheng and Bronder, Thomas and Poghossian, Arshak and Werner, Frederik and B{\"a}cker, Matthias and Sch{\"o}ning, Michael Josef}, title = {Label-free electrical detection of DNA with a multi-spot LAPS: First step towards light-addressable DNA chips}, series = {Physica status solidi A : Applications and materials science}, volume = {211}, journal = {Physica status solidi A : Applications and materials science}, number = {6}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1521-396X (E-Journal); 1862-6319 (E-Journal); 0031-8965 (Print); 1862-6300 (Print)}, doi = {10.1002/pssa.201330442}, pages = {1423 -- 1428}, year = {2014}, abstract = {A multi-spot (4 × 4 spots) light-addressable potentiometric sensor (MLAPS) consisting of an Al-p-Si-SiO2 structure has been applied for the label-free electrical detection of DNA (deoxyribonucleic acid) immobilization and hybridization by the intrinsic molecular charge for the first time. Single-stranded probe ssDNA molecules (20 bases) were covalently immobilized onto the silanized SiO2 gate surface. The unspecific adsorption of mismatch ssDNA on the MLAPS gate surface was blocked by bovine serum albumin molecules. To reduce the screening effect and to achieve a high sensor signal, the measurements were performed in a low ionic-strength solution. The photocurrent-voltage (I-V) curves were simultaneously recorded on all 16 spots after each surface functionalization step. Large shifts of I-V curves of 25 mV were registered after the DNA immobilization and hybridization event. In contrast, a small potential shift (∼5 mV) was observed in case of mismatch ssDNA, revealing good specificity of the sensor. The obtained results demonstrate the potential of the MLAPS as promising transducer platform for the multi-spot label-free electrical detection of DNA molecules by their intrinsic molecular charge.}, language = {en} } @article{FerreinFritzLakemeyer2004, author = {Ferrein, Alexander and Fritz, Christian and Lakemeyer, Gerhard}, title = {On-Line Decision-Theoretic Golog for Unpredictable Domains / Ferrein, Alexander ; Fritz, Christian ; Lakemeyer, Gerhard}, series = {KI 2004: Advances in Artificial Intelligence : 27th Annual German Conference on AI, KI 2004, Ulm, Germany, September 20-24, 2004. Proceedings}, journal = {KI 2004: Advances in Artificial Intelligence : 27th Annual German Conference on AI, KI 2004, Ulm, Germany, September 20-24, 2004. Proceedings}, publisher = {Springer}, address = {Berlin}, pages = {322 -- 336}, year = {2004}, language = {en} } @article{PoghossianJablonskiMolinnusetal.2020, author = {Poghossian, Arshak and Jablonski, Melanie and Molinnus, Denise and Wege, Christina and Sch{\"o}ning, Michael Josef}, title = {Field-Effect Sensors for Virus Detection: From Ebola to SARS-CoV-2 and Plant Viral Enhancers}, series = {Frontiers in Plant Science}, volume = {11}, journal = {Frontiers in Plant Science}, number = {Article 598103}, publisher = {Frontiers}, address = {Lausanne}, doi = {10.3389/fpls.2020.598103}, pages = {1 -- 14}, year = {2020}, abstract = {Coronavirus disease 2019 (COVID-19) is a novel human infectious disease provoked by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Currently, no specific vaccines or drugs against COVID-19 are available. Therefore, early diagnosis and treatment are essential in order to slow the virus spread and to contain the disease outbreak. Hence, new diagnostic tests and devices for virus detection in clinical samples that are faster, more accurate and reliable, easier and cost-efficient than existing ones are needed. Due to the small sizes, fast response time, label-free operation without the need for expensive and time-consuming labeling steps, the possibility of real-time and multiplexed measurements, robustness and portability (point-of-care and on-site testing), biosensors based on semiconductor field-effect devices (FEDs) are one of the most attractive platforms for an electrical detection of charged biomolecules and bioparticles by their intrinsic charge. In this review, recent advances and key developments in the field of label-free detection of viruses (including plant viruses) with various types of FEDs are presented. In recent years, however, certain plant viruses have also attracted additional interest for biosensor layouts: Their repetitive protein subunits arranged at nanometric spacing can be employed for coupling functional molecules. If used as adapters on sensor chip surfaces, they allow an efficient immobilization of analyte-specific recognition and detector elements such as antibodies and enzymes at highest surface densities. The display on plant viral bionanoparticles may also lead to long-time stabilization of sensor molecules upon repeated uses and has the potential to increase sensor performance substantially, compared to conventional layouts. This has been demonstrated in different proof-of-concept biosensor devices. Therefore, richly available plant viral particles, non-pathogenic for animals or humans, might gain novel importance if applied in receptor layers of FEDs. These perspectives are explained and discussed with regard to future detection strategies for COVID-19 and related viral diseases.}, language = {en} } @article{BialonskiHorstmannLehnertz2010, author = {Bialonski, Stephan and Horstmann, Marie-Therese and Lehnertz, Klaus}, title = {From brain to earth and climate systems: Small-world interaction networks or not?}, series = {Chaos: An Interdisciplinary Journal of Nonlinear Science}, volume = {20}, journal = {Chaos: An Interdisciplinary Journal of Nonlinear Science}, number = {1}, publisher = {AIP Publishing}, address = {Melville, NY}, issn = {1089-7682}, doi = {10.1063/1.3360561}, pages = {013134}, year = {2010}, abstract = {We consider recent reports on small-world topologies of interaction networks derived from the dynamics of spatially extended systems that are investigated in diverse scientific fields such as neurosciences, geophysics, or meteorology. With numerical simulations that mimic typical experimental situations, we have identified an important constraint when characterizing such networks: indications of a small-world topology can be expected solely due to the spatial sampling of the system along with the commonly used time series analysis based approaches to network characterization.}, language = {en} } @article{Weigand2000, author = {Weigand, Christoph}, title = {Economically Optimal Adaptive Inspection Policies}, series = {Economic Quality Control. 15 (2000), H. 1/2}, journal = {Economic Quality Control. 15 (2000), H. 1/2}, isbn = {0940-5151}, pages = {55 -- 77}, year = {2000}, language = {en} } @article{AlKaidyDuweHusteretal.2015, author = {Al-Kaidy, Huschyar and Duwe, Anna and Huster, Manuel and Muffler, Kai and Schlegel, Christin and Tim, Sieker and Stadtm{\"u}ller, Ralf and Tippk{\"o}tter, Nils and Ulber, Roland}, title = {Biotechnology and bioprocess engineering - from the first ullmann's article to recent trends}, series = {ChemBioEng Reviews}, volume = {2}, journal = {ChemBioEng Reviews}, number = {3}, publisher = {Wiley}, address = {Weinheim}, doi = {10.1002/cben.201500008}, pages = {175 -- 184}, year = {2015}, abstract = {For several thousand years, biotechnology and its associated technical processes have had a great impact on the development of mankind. Based on empirical methods, in particular for the production of foodstuffs and daily commodities, these disciplines have become one of the most innovative future issues. Due to the increasing detailed understanding of cellular processes, production strains can now be optimized. In combination with modern bioprocesses, a variety of bulk and fine chemicals as well as pharmaceuticals can be produced efficiently. In this article, some of the current trends in biotechnology are discussed.}, language = {en} } @article{SchindlerBialonskiHorstmannetal.2008, author = {Schindler, Kaspar A. and Bialonski, Stephan and Horstmann, Marie-Therese and Elger, Christian E. and Lehnertz, Klaus}, title = {Evolving functional network properties and synchronizability during human epileptic seizures}, series = {Chaos: An Interdisciplinary Journal of Nonlinear Science}, volume = {18}, journal = {Chaos: An Interdisciplinary Journal of Nonlinear Science}, number = {3}, issn = {1089-7682}, doi = {10.1063/1.2966112}, pages = {033119}, year = {2008}, language = {en} } @article{Weigand1993, author = {Weigand, Christoph}, title = {On the Effects of SPC on Production Time}, series = {Economic Quality Control. 8 (1993)}, journal = {Economic Quality Control. 8 (1993)}, isbn = {0940-5151}, pages = {23 -- 61}, year = {1993}, language = {en} } @article{HeuermannEmmrichBongartz2022, author = {Heuermann, Holger and Emmrich, Thomas and Bongartz, Simon}, title = {Microwave spark plug to support ignitions with high compression ratios}, series = {IEEE Transactions on Plasma Science}, journal = {IEEE Transactions on Plasma Science}, number = {Early Access}, publisher = {IEEE}, issn = {1939-9375}, doi = {10.1109/TPS.2022.3183690}, pages = {1 -- 6}, year = {2022}, abstract = {Upcoming gasoline engines should run with a larger number of fuels beginning from petrol over methanol up to gas by a wide range of compression ratios and a homogeneous charge. In this article, the microwave (MW) spark plug, based on a high-speed frequency hopping system, is introduced as a solution, which can support a nitrogen compression ratio up to 1:39 in a chamber and more. First, an overview of the high-speed frequency hopping MW ignition and operation system as well as the large number of applications are presented. Both gives an understanding of this new base technology for MW plasma generation. Focus of the theoretical part is the explanation of the internal construction of the spark plug, on the achievable of the high voltage generation as well as the high efficiency to hold the plasma. In detail, the development process starting with circuit simulations and ending with the numerical multiphysics field simulations is described. The concept is evaluated with a reference prototype covering the frequency range between 2.40 and 2.48 GHz and working over a large power range from 20 to 200 W. A larger number of different measurements starting by vector hot-S11 measurements and ending by combined working scenarios out of hot temperature, high pressure and charge motion are winding up the article. The limits for the successful pressure tests were given by the pressure chamber. Pressures ranged from 1 to 39 bar and charge motion up to 25 m/s as well as temperatures from 30◦ to 125◦.}, language = {en} } @article{SchusserLeinhosBaeckeretal.2013, author = {Schusser, Sebastian and Leinhos, Marcel and B{\"a}cker, Matthias and Poghossian, Arshak and Wagner, Patrick and Sch{\"o}ning, Michael Josef}, title = {Impedance spectroscopy: A tool for real-time in situ monitoring of the degradation of biopolymers}, series = {Physica Status Solidi (A)}, volume = {210}, journal = {Physica Status Solidi (A)}, number = {5}, publisher = {Wiley}, address = {Weinheim}, issn = {1521-396X ; 0031-8965}, doi = {10.1002/pssa.201200941}, pages = {905 -- 910}, year = {2013}, abstract = {Investigation of the degradation kinetics of biodegradable polymers is essential for the development of implantable biomedical devices with predicted biodegradability. In this work, an impedimetric sensor has been applied for real-time and in situ monitoring of degradation processes of biopolymers. The sensor consists of two platinum thin-film electrodes covered by a polymer film to be studied. The benchmark biomedical polymer poly(D,L-lactic acid) (PDLLA) was used as a model system. PDLLA films were deposited on the sensor structure from a polymer solution by using the spin-coating method. The degradation kinetics of PDLLA films have been studied in alkaline solutions of pH 9 and 12 by means of an impedance spectroscopy (IS) method. Any changes in a polymer capacitance/resistance induced by water uptake and/or polymer degradation will modulate the global impedance of the polymer-covered sensor that can be used as an indicator of the polymer degradation. The degradation rate can be evaluated from the time-dependent impedance spectra. As expected, a faster degradation has been observed for PDLLA films exposed to pH 12 solution.}, language = {en} } @article{PothMonzonTippkoetteretal.2011, author = {Poth, Sebastian and Monzon, Magaly and Tippk{\"o}tter, Nils and Ulber, Roland}, title = {Lignocellulosic biorefinery: Process integration of hydrolysis and fermentation (SSF process)}, series = {Holzforschung}, volume = {65}, journal = {Holzforschung}, number = {5}, publisher = {De Gruyter}, address = {Berlin}, pages = {633 -- 637}, year = {2011}, abstract = {The aim of the present work is the process integration and the optimization of the enzymatic hydrolysis of wood and the following fermentation of the products to ethanol. The substrate is a fiber fraction obtained by organosolv pre-treatment of beech wood. For the ethanol production, a co-fermentation by two different yeasts (Saccharomyces cerevisiae and Pachysolen tannophilus) was carried out to convert glucose as well as xylose. Two approaches has been followed: 1. A two step process, in which the hydrolysis of the fiber fraction and the fermentation to product are separated from each other. 2. A process, in which the hydrolysis and the fermentation are carried out in one single process step as simultaneous saccharification and fermentation (SSF). Following the first approach, a yield of about 0.15 g ethanol per gram substrate can be reached. Based on the SSF, one process step can be saved, and additionally, the gained yield can be raised up to 0.3 g ethanol per gram substrate.}, language = {en} } @article{FunkeBeckmannKeinzetal.2016, author = {Funke, Harald and Beckmann, Nils and Keinz, Jan and Abanteriba, Sylvester}, title = {Comparison of Numerical Combustion Models for Hydrogen and Hydrogen-Rich Syngas Applied for Dry-Low-NOx-Micromix-Combustion}, series = {ASME Turbo Expo 2016: Turbomachinery Technical Conference and Exposition Volume 4A: Combustion, Fuels and Emissions Seoul, South Korea, June 13-17, 2016}, journal = {ASME Turbo Expo 2016: Turbomachinery Technical Conference and Exposition Volume 4A: Combustion, Fuels and Emissions Seoul, South Korea, June 13-17, 2016}, publisher = {ASME}, address = {New York, NY}, isbn = {978-0-7918-4975-0}, doi = {10.1115/GT2016-56430}, pages = {12}, year = {2016}, abstract = {The Dry-Low-NOₓ (DLN) Micromix combustion technology has been developed as low emission combustion principle for industrial gas turbines fueled with hydrogen or syngas. The combustion process is based on the phenomenon of jet-in-crossflow-mixing. Fuel is injected perpendicular into the air-cross-flow and burned in a multitude of miniaturized, diffusion-like flames. The miniaturization of the flames leads to a significant reduction of NOₓ emissions due to the very short residence time of reactants in the flame. In the Micromix research approach, CFD analyses are validated towards experimental results. The combination of numerical and experimental methods allows an efficient design and optimization of DLN Micromix combustors concerning combustion stability and low NOₓ emissions. The paper presents a comparison of several numerical combustion models for hydrogen and hydrogen-rich syngas. They differ in the complexity of the underlying reaction mechanism and the associated computational effort. For pure hydrogen combustion a one-step global reaction is applied using a hybrid Eddy-Break-up model that incorporates finite rate kinetics. The model is evaluated and compared to a detailed hydrogen combustion mechanism derived by Li et al. including 9 species and 19 reversible elementary reactions. Based on this mechanism, reduction of the computational effort is achieved by applying the Flamelet Generated Manifolds (FGM) method while the accuracy of the detailed reaction scheme is maintained. For hydrogen-rich syngas combustion (H₂-CO) numerical analyses based on a skeletal H₂/CO reaction mechanism derived by Hawkes et al. and a detailed reaction mechanism provided by Ranzi et al. are performed. The comparison between combustion models and the validation of numerical results is based on exhaust gas compositions available from experimental investigation on DLN Micromix combustors. The conducted evaluation confirms that the applied detailed combustion mechanisms are able to predict the general physics of the DLN-Micromix combustion process accurately. The Flamelet Generated Manifolds method proved to be generally suitable to reduce the computational effort while maintaining the accuracy of detailed chemistry. Especially for reaction mechanisms with a high number of species accuracy and computational effort can be balanced using the FGM model.}, language = {en} } @article{GrajewskiKoesterTurek2009, author = {Grajewski, Matthias and K{\"o}ster, Michael and Turek, Stefan}, title = {Mathematical and Numerical Analysis of a Robust and Efficient Grid Deformation Method in the Finite Element Context}, series = {SIAM Journal on Scientific Computing}, volume = {31}, journal = {SIAM Journal on Scientific Computing}, number = {2}, publisher = {Society for Industrial and Applied Mathematics}, address = {Philadelphia, Pa.}, doi = {10.1137/050639387}, pages = {1539 -- 1557}, year = {2009}, language = {en} } @article{AimenovaDigelEshibaev2016, author = {Aimenova, Zh. E. and Digel, Ilya and Eshibaev, А. А.}, title = {Dynamics of accumulation of lagochirzin in Lagochilus setulosus phytomass during the growing season and also features of its cultivation in the conditions of a typical sierozem}, series = {KazNU Bulletin. Biology series}, volume = {69}, journal = {KazNU Bulletin. Biology series}, number = {4}, publisher = {Al-Farabi Kazakh National University}, address = {Almaty}, issn = {1563-0218}, pages = {4 -- 11}, year = {2016}, abstract = {L.setulosus is offered for creation of biopreparation «Setulin», possesing he- mostatic action, the basic reactant of biopreparation is diterpen - lagochirzin. Results under the maintenance and dynamics of diterpen lagochirzin accumula- tion in various parts of L.setulosus are presented: in roots, stalks, leaves, flowers and calyx lobes during the growing season, and also results on conditions of cultivation L.setulosus in the conditions of a typical sierozem are resulted. From the obtained data is visible, that the given species of a plant is endemic. It is established, that dynamics of accumulation of lagochirzin in phytomass accrues from the beginning to the middle of the growing season. The chemical analysis of L.setulosus on a localization of lagochirzin in various organs of a plant, has shown, that the greatest quantity of lagochirzin collects in calyx lobes of the plants. Also it is established, that L.setulosus can be cultivated in the conditions of the typical sierozem, a mineral food is necessary for the given species of plants of Lagochilus genus, except nitric fertilizers. Comparative studying of wild-growing and cultural forms of L.setulosus has shown, that in the cultivated phytomass of plants the maintenance of lagochirzin on 17-20 \% higher than in the wild-growing species.}, language = {en} } @article{Ritz2000, author = {Ritz, Thomas}, title = {Personalized information services : an electronic information commodity and its production}, series = {International Journal of E-Business Strategy Management}, volume = {2}, journal = {International Journal of E-Business Strategy Management}, number = {2}, issn = {1467-0305}, year = {2000}, language = {en} } @article{AkimbekovDigelSavitkayaetal.2013, author = {Akimbekov, Nuraly S. and Digel, Ilya and Savitkaya, I.S. and Zhubanova, A.A. and Tastambek, K.T.}, title = {Investigations of LPS endotoxin elimination in the flowing column conditions with the sorbent on the basis of carbonized rice husk}, series = {KazNU Bulletin. Biology series}, volume = {57}, journal = {KazNU Bulletin. Biology series}, number = {1}, issn = {1563-0218}, pages = {124 -- 127}, year = {2013}, language = {en} } @article{GerigkBujnickiGanpoNkwenkwaetal.2002, author = {Gerigk, M. and Bujnicki, R. and Ganpo-Nkwenkwa, E. and Bongaerts, Johannes and Sprenger, G. and Takors, Ralf}, title = {Process control for enhanced L-phenylalanine production using different recombinant Escherichia coli strains}, series = {Biotechnology and bioengineering}, volume = {Vol. 80}, journal = {Biotechnology and bioengineering}, number = {Iss. 7}, issn = {1097-0290 (E-Journal); 0006-3592 (Print)}, pages = {746 -- 754}, year = {2002}, language = {en} } @article{FerreinJacobsLakemeyer2005, author = {Ferrein, Alexander and Jacobs, Stefan and Lakemeyer, Gerhard}, title = {Unreal Golog Bots / Jacobs, Stefan ; Ferrein, Alexander ; Lakemeyer, Gerhard}, series = {IJCAI-05 Workshop on Reasoning, Representation, and Learning in Computer Games}, journal = {IJCAI-05 Workshop on Reasoning, Representation, and Learning in Computer Games}, pages = {31 -- 36}, year = {2005}, language = {en} } @article{HeuermannSchiek1997, author = {Heuermann, Holger and Schiek, B.}, title = {Results of network analyzer measurements with leakage errors-corrected with direct calibration techniques}, series = {IEEE transactions on instrumentation and measurement : IM / Institute of Electrical and Electronics Engineers, Instrumentation and Measurement Group. 46 (1997), H. 5}, journal = {IEEE transactions on instrumentation and measurement : IM / Institute of Electrical and Electronics Engineers, Instrumentation and Measurement Group. 46 (1997), H. 5}, isbn = {0018-9456}, pages = {1120 -- 1127}, year = {1997}, language = {en} } @article{FingerBraunBil2020, author = {Finger, Felix and Braun, Carsten and Bil, Cees}, title = {Comparative assessment of parallel-hybrid-electric propulsion systems for four different aircraft}, series = {Journal of Aircraft}, volume = {57}, journal = {Journal of Aircraft}, number = {5}, publisher = {AIAA}, address = {Reston, Va.}, issn = {1533-3868}, doi = {10.2514/1.C035897}, year = {2020}, abstract = {Until electric energy storage systems are ready to allow fully electric aircraft, the combination of combustion engine and electric motor as a hybrid-electric propulsion system seems to be a promising intermediate solution. Consequently, the design space for future aircraft is expanded considerably, as serial hybrid-electric, parallel hybrid-electric, fully electric, and conventional propulsion systems must all be considered. While the best propulsion system depends on a multitude of requirements and considerations, trends can be observed for certain types of aircraft and certain types of missions. This Paper provides insight into some factors that drive a new design toward either conventional or hybrid propulsion systems. General aviation aircraft, regional transport aircraft vertical takeoff and landing air taxis, and unmanned aerial vehicles are chosen as case studies. Typical missions for each class are considered, and the aircraft are analyzed regarding their takeoff mass and primary energy consumption. For these case studies, a high-level approach is chosen, using an initial sizing methodology. Only parallel-hybrid-electric powertrains are taken into account. Aeropropulsive interaction effects are neglected. Results indicate that hybrid-electric propulsion systems should be considered if the propulsion system is sized by short-duration power constraints. However, if the propulsion system is sized by a continuous power requirement, hybrid-electric systems offer hardly any benefit.}, language = {en} } @article{BongaertsBovenbergKraemeretal.2002, author = {Bongaerts, Johannes and Bovenberg, Roel and Kr{\"a}mer, Marco and M{\"u}ller, Ulrike and Raeven, Leon and Wubbolts, Marcel}, title = {Metabolic engineering to produce fine chemicals in Escherichia coli}, series = {Chemie - Ingenieur - Technik (CIT)}, volume = {Vol. 74}, journal = {Chemie - Ingenieur - Technik (CIT)}, number = {Iss. 5}, issn = {1522-2640 (E-Journal); 0009-286X (Print)}, pages = {694}, year = {2002}, language = {en} } @article{BialonskiWellmerElgeretal.2006, author = {Bialonski, Stephan and Wellmer, J{\"o}rg and Elger, Christian E. and Lehnertz, Klaus}, title = {Interictal focus localization in neocortical lesional epilepsies with synchronization cluster analysis}, series = {Epilepsia}, volume = {47}, journal = {Epilepsia}, issn = {0013-9580}, pages = {36}, year = {2006}, language = {en} } @article{FerreinBoehnstedtLakemeyer2007, author = {Ferrein, Alexander and B{\"o}hnstedt, Lutz and Lakemeyer, Gerhard}, title = {Options in readylog reloaded -- generating decision-theoretic plan libraries in golog / B{\"o}hnstedt, Lutz ; Ferrein, Alexander ; Lakemeyer, Gerhard}, series = {KI 2007: advances in artificial intelligence : 30th Annual German Conference on AI, KI 2007, Osnabr{\"u}ck, Germany, September 10 - 13, 2007 ; proceedings}, journal = {KI 2007: advances in artificial intelligence : 30th Annual German Conference on AI, KI 2007, Osnabr{\"u}ck, Germany, September 10 - 13, 2007 ; proceedings}, publisher = {Springer}, address = {Berlin}, isbn = {978-3-540-74564-8}, pages = {352 -- 366}, year = {2007}, language = {en} } @article{Heuermann1995, author = {Heuermann, Holger}, title = {LZY: A Self-Calibration Approach in Competition to the LRM Method for On-Wafer Measurements}, pages = {129 -- 136}, year = {1995}, language = {en} } @article{WolfFoltzSchlicketal.2002, author = {Wolf, Martin R. and Foltz, Christian and Schlick, Christopher and Luczak, Holger}, title = {Development and evaluation of a groupware system to support chemical design processes / Wolf, Martin ; Foltz, Christian ; Schlick, Christopher ; Luczak, Holger}, series = {International Journal of Human-Computer Interaction . 14 (2002), H. 2}, journal = {International Journal of Human-Computer Interaction . 14 (2002), H. 2}, publisher = {-}, isbn = {1044-7318}, pages = {181 -- 198}, year = {2002}, language = {en} } @article{BongaertsZoschkeWeidneretal.1995, author = {Bongaerts, Johannes and Zoschke, Sascha and Weidner, Uwe and Linden, Gottfried}, title = {Transcriptional regulation of the proton translocating NADH}, series = {Molecular microbiology}, volume = {Vol. 16}, journal = {Molecular microbiology}, number = {Iss. 3}, issn = {1365-2958 (E-Journal); 0950-382x (Print)}, pages = {521 -- 534}, year = {1995}, language = {en} } @article{Staat1996, author = {Staat, Manfred}, title = {Problems and Chances for Probabilistic Fracture Mechanics in the Analysis of Steel Pressure Boundary Reliability}, series = {Technical feasibility and reliability of passive safety systems for nuclear power plants. Proceedings of an Advisory Group Meeting held in J{\"u}lich, 21-24 November 1994}, journal = {Technical feasibility and reliability of passive safety systems for nuclear power plants. Proceedings of an Advisory Group Meeting held in J{\"u}lich, 21-24 November 1994}, address = {Vienna}, pages = {43 -- 55}, year = {1996}, language = {en} } @article{Stulpe1988, author = {Stulpe, Werner}, title = {Conditional Expectations, Conditional Distributions, and A Posteriori Ensembles in Generalized Probability Theory}, series = {International Journal of Theoretical Physics. 27 (1988), H. 5}, journal = {International Journal of Theoretical Physics. 27 (1988), H. 5}, isbn = {1572-9575}, pages = {587 -- 611}, year = {1988}, language = {en} } @article{KarschuckPoghossianSeretal.2024, author = {Karschuck, Tobias and Poghossian, Arshak and Ser, Joey and Tsokolakyan, Astghik and Achtsnicht, Stefan and Wagner, Patrick and Sch{\"o}ning, Michael Josef}, title = {Capacitive model of enzyme-modified field-effect biosensors: Impact of enzyme coverage}, series = {Sensors and Actuators B: Chemical}, volume = {408}, journal = {Sensors and Actuators B: Chemical}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0925-4005 (Print)}, doi = {10.1016/j.snb.2024.135530}, pages = {12 Seiten}, year = {2024}, abstract = {Electrolyte-insulator-semiconductor capacitors (EISCAP) belong to field-effect sensors having an attractive transducer architecture for constructing various biochemical sensors. In this study, a capacitive model of enzyme-modified EISCAPs has been developed and the impact of the surface coverage of immobilized enzymes on its capacitance-voltage and constant-capacitance characteristics was studied theoretically and experimentally. The used multicell arrangement enables a multiplexed electrochemical characterization of up to sixteen EISCAPs. Different enzyme coverages have been achieved by means of parallel electrical connection of bare and enzyme-covered single EISCAPs in diverse combinations. As predicted by the model, with increasing the enzyme coverage, both the shift of capacitance-voltage curves and the amplitude of the constant-capacitance signal increase, resulting in an enhancement of analyte sensitivity of the EISCAP biosensor. In addition, the capability of the multicell arrangement with multi-enzyme covered EISCAPs for sequentially detecting multianalytes (penicillin and urea) utilizing the enzymes penicillinase and urease has been experimentally demonstrated and discussed.}, language = {en} } @article{MonakhovaDiehl2021, author = {Monakhova, Yulia and Diehl, Bernd W.K.}, title = {Novel approach of qNMR workflow by standardization using 2H integral: Application to any intrinsic calibration standard}, series = {Talanta}, volume = {222}, journal = {Talanta}, number = {Article number: 121504}, publisher = {Elsevier}, isbn = {0039-9140}, doi = {10.1016/j.talanta.2020.121504}, year = {2021}, abstract = {Quantitative nuclear magnetic resonance (qNMR) is routinely performed by the internal or external standardization. The manuscript describes a simple alternative to these common workflows by using NMR signal of another active nuclei of calibration compound. For example, for any arbitrary compound quantification by NMR can be based on the use of an indirect concentration referencing that relies on a solvent having both 1H and 2H signals. To perform high-quality quantification, the deuteration level of the utilized deuterated solvent has to be estimated. In this contribution the new method was applied to the determination of deuteration levels in different deuterated solvents (MeOD, ACN, CDCl3, acetone, benzene, DMSO-d6). Isopropanol-d6, which contains a defined number of deuterons and protons, was used for standardization. Validation characteristics (precision, accuracy, robustness) were calculated and the results showed that the method can be used in routine practice. Uncertainty budget was also evaluated. In general, this novel approach, using standardization by 2H integral, benefits from reduced sample preparation steps and uncertainties, and can be applied in different application areas (purity determination, forensics, pharmaceutical analysis, etc.).}, language = {en} } @article{MonakhovaDiehl2022, author = {Monakhova, Yulia and Diehl, Bernd W.K.}, title = {Multinuclear NMR screening of pharmaceuticals using standardization by 2H integral of a deuterated solvent}, series = {Journal of Pharmaceutical and Biomedical Analysis}, volume = {209}, journal = {Journal of Pharmaceutical and Biomedical Analysis}, number = {Article number: 114530}, publisher = {Elsevier}, isbn = {0731-7085}, doi = {10.1016/j.jpba.2021.114530}, year = {2022}, abstract = {NMR standardization approach that uses the 2H integral of deuterated solvent for quantitative multinuclear analysis of pharmaceuticals is described. As a proof of principle, the existing NMR procedure for the analysis of heparin products according to US Pharmacopeia monograph is extended to the determination of Na+ and Cl- content in this matrix. Quantification is performed based on the ratio of a 23Na (35Cl) NMR integral and 2H NMR signal of deuterated solvent, D2O, acquired using the specific spectrometer hardware. As an alternative, the possibility of 133Cs standardization using the addition of Cs2CO3 stock solution is shown. Validation characteristics (linearity, repeatability, sensitivity) are evaluated. A holistic NMR profiling of heparin products can now also be used for the quantitative determination of inorganic compounds in a single analytical run using a single sample. In general, the new standardization methodology provides an appealing alternative for the NMR screening of inorganic and organic components in pharmaceutical products.}, language = {en} } @article{OezsoyluKizildagSchoeningetal.2020, author = {{\"O}zsoylu, Dua and Kizildag, Sefa and Sch{\"o}ning, Michael Josef and Wagner, Torsten}, title = {Differential chemical imaging of extracellular acidification within microfluidic channels using a plasma-functionalized light-addressable potentiometric sensor (LAPS)}, series = {Physics in Medicine}, volume = {10}, journal = {Physics in Medicine}, number = {100030}, publisher = {Elsevier}, address = {Amsterdam}, issn = {2352-4510}, doi = {10.1016/j.phmed.2020.100030}, pages = {8}, year = {2020}, abstract = {Extracellular acidification is a basic indicator for alterations in two vital metabolic pathways: glycolysis and cellular respiration. Measuring these alterations by monitoring extracellular acidification using cell-based biosensors such as LAPS plays an important role in studying these pathways whose disorders are associated with numerous diseases including cancer. However, the surface of the biosensors must be specially tailored to ensure high cell compatibility so that cells can represent more in vivo-like behavior, which is critical to gain more realistic in vitro results from the analyses, e.g., drug discovery experiments. In this work, O2 plasma patterning on the LAPS surface is studied to enhance surface features of the sensor chip, e.g., wettability and biofunctionality. The surface treated with O2 plasma for 30 s exhibits enhanced cytocompatibility for adherent CHO-K1 cells, which promotes cell spreading and proliferation. The plasma-modified LAPS chip is then integrated into a microfluidic system, which provides two identical channels to facilitate differential measurements of the extracellular acidification of CHO-K1 cells. To the best of our knowledge, it is the first time that extracellular acidification within microfluidic channels is quantitatively visualized as differential (bio-)chemical images.}, language = {en} } @article{EngelmannPourshahidiShalabyetal.2022, author = {Engelmann, Ulrich M. and Pourshahidi, Mohammad Ali and Shalaby, Ahmed and Krause, Hans-Joachim}, title = {Probing particle size dependency of frequency mixing magnetic detection with dynamic relaxation simulation}, series = {Journal of Magnetism and Magnetic Materials}, volume = {563}, journal = {Journal of Magnetism and Magnetic Materials}, number = {In progress, Art. No. 169965}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0304-8853}, doi = {10.1016/j.jmmm.2022.169965}, year = {2022}, abstract = {Biomedical applications of magnetic nanoparticles (MNP) fundamentally rely on the particles' magnetic relaxation as a response to an alternating magnetic field. The magnetic relaxation complexly depends on the interplay of MNP magnetic and physical properties with the applied field parameters. It is commonly accepted that particle core size is a major contributor to signal generation in all the above applications, however, most MNP samples comprise broad distribution spanning nm and more. Therefore, precise knowledge of the exact contribution of individual core sizes to signal generation is desired for optimal MNP design generally for each application. Specifically, we present a magnetic relaxation simulation-driven analysis of experimental frequency mixing magnetic detection (FMMD) for biosensing to quantify the contributions of individual core size fractions towards signal generation. Applying our method to two different experimental MNP systems, we found the most dominant contributions from approx. 20 nm sized particles in the two independent MNP systems. Additional comparison between freely suspended and immobilized MNP also reveals insight in the MNP microstructure, allowing to use FMMD for MNP characterization, as well as to further fine-tune its applicability in biosensing.}, language = {en} } @article{AchtsnichtToedterNiehuesetal.2019, author = {Achtsnicht, Stefan and T{\"o}dter, Julia and Niehues, Julia and Tel{\"o}ken, Matthias and Offenh{\"a}usser, Andreas and Krause, Hans-Joachim and Schr{\"o}per, Florian}, title = {3D printed modular immunofiltration columns for frequency mixing-based multiplex magnetic immunodetection}, series = {Sensors}, volume = {19}, journal = {Sensors}, number = {1}, publisher = {MDPI}, address = {Basel}, issn = {1424-8220}, doi = {10.3390/s19010148}, pages = {15 Seiten}, year = {2019}, abstract = {For performing point-of-care molecular diagnostics, magnetic immunoassays constitute a promising alternative to established enzyme-linked immunosorbent assays (ELISA) because they are fast, robust and sensitive. Simultaneous detection of multiple biomolecular targets from one body fluid sample is desired. The aim of this work is to show that multiplex magnetic immunodetection based on magnetic frequency mixing by means of modular immunofiltration columns prepared for different targets is feasible. By calculations of the magnetic response signal, the required spacing between the modules was determined. Immunofiltration columns were manufactured by 3D printing and antibody immobilization was performed in a batch approach. It was shown experimentally that two different target molecules in a sample solution could be individually detected in a single assaying step with magnetic measurements of the corresponding immobilization filters. The arrangement order of the filters and of a negative control did not influence the results. Thus, a simple and reliable approach to multi-target magnetic immunodetection was demonstrated.}, language = {en} } @article{HeuermannSadeghfam2009, author = {Heuermann, Holger and Sadeghfam, Arash}, title = {Enhanced system architecture for rugged wide band data transmission / Sadeghfam, A. ; Heuermann, H.}, series = {European Radar Conference, 2009 : EuRAD 2009 ; Sept. 30 - Oct. 2 2009, Rome, Italy ; part of the European Microwave Week (EuMW) / sponsored by EuMA, European Microwave Association}, journal = {European Radar Conference, 2009 : EuRAD 2009 ; Sept. 30 - Oct. 2 2009, Rome, Italy ; part of the European Microwave Week (EuMW) / sponsored by EuMA, European Microwave Association}, publisher = {IEEE}, address = {Piscataway, NJ}, isbn = {978-2-87487-014-9}, pages = {347 -- 350}, year = {2009}, language = {en} } @article{TrappLammersEngudaretal.2023, author = {Trapp, Svenja and Lammers, Tom and Engudar, Gokce and Hoehr, Cornelia and Denkova, Antonia G. and Paulßen, Elisabeth and de Kruijff, Robin M.}, title = {Membrane-based microfluidic solvent extraction of Ga-68 from aqueous Zn solutions: towards an automated cyclotron production loop}, series = {EJNMMI Radiopharmacy and Chemistry}, volume = {2023}, journal = {EJNMMI Radiopharmacy and Chemistry}, number = {8, Article number: 9}, publisher = {Springer Nature}, issn = {2365-421X}, doi = {10.1186/s41181-023-00195-2}, pages = {1 -- 14}, year = {2023}, language = {en} } @article{EngelmannShalabyShashaetal.2021, author = {Engelmann, Ulrich M. and Shalaby, Ahmed and Shasha, Carolyn and Krishnan, Kannan M. and Krause, Hans-Joachim}, title = {Comparative modeling of frequency mixing measurements of magnetic nanoparticles using micromagnetic simulations and Langevin theory}, series = {Nanomaterials}, volume = {11}, journal = {Nanomaterials}, number = {5}, publisher = {MDPI}, address = {Basel}, isbn = {2079-4991}, doi = {10.3390/nano11051257}, pages = {1 -- 16}, year = {2021}, abstract = {Dual frequency magnetic excitation of magnetic nanoparticles (MNP) enables enhanced biosensing applications. This was studied from an experimental and theoretical perspective: nonlinear sum-frequency components of MNP exposed to dual-frequency magnetic excitation were measured as a function of static magnetic offset field. The Langevin model in thermodynamic equilibrium was fitted to the experimental data to derive parameters of the lognormal core size distribution. These parameters were subsequently used as inputs for micromagnetic Monte-Carlo (MC)-simulations. From the hysteresis loops obtained from MC-simulations, sum-frequency components were numerically demodulated and compared with both experiment and Langevin model predictions. From the latter, we derived that approximately 90\% of the frequency mixing magnetic response signal is generated by the largest 10\% of MNP. We therefore suggest that small particles do not contribute to the frequency mixing signal, which is supported by MC-simulation results. Both theoretical approaches describe the experimental signal shapes well, but with notable differences between experiment and micromagnetic simulations. These deviations could result from Brownian relaxations which are, albeit experimentally inhibited, included in MC-simulation, or (yet unconsidered) cluster-effects of MNP, or inaccurately derived input for MC-simulations, because the largest particles dominate the experimental signal but concurrently do not fulfill the precondition of thermodynamic equilibrium required by Langevin theory.}, language = {en} } @article{AliaziziOezsoyluBakhshiSichanietal.2024, author = {Aliazizi, Fereshteh and {\"O}zsoylu, Dua and Bakhshi Sichani, Soroush and Khorshid, Mehran and Glorieux, Christ and Robbens, Johan and Sch{\"o}ning, Michael Josef and Wagner, Patrick}, title = {Development and Calibration of a Microfluidic, Chip-Based Sensor System for Monitoring the Physical Properties of Water Samples in Aquacultures}, series = {Micromachines}, volume = {15}, journal = {Micromachines}, number = {6}, publisher = {MDPI}, address = {Basel}, issn = {2072-666X}, doi = {10.3390/mi15060755}, year = {2024}, abstract = {In this work, we present a compact, bifunctional chip-based sensor setup that measures the temperature and electrical conductivity of water samples, including specimens from rivers and channels, aquaculture, and the Atlantic Ocean. For conductivity measurements, we utilize the impedance amplitude recorded via interdigitated electrode structures at a single triggering frequency. The results are well in line with data obtained using a calibrated reference instrument. The new setup holds for conductivity values spanning almost two orders of magnitude (river versus ocean water) without the need for equivalent circuit modelling. Temperature measurements were performed in four-point geometry with an on-chip platinum RTD (resistance temperature detector) in the temperature range between 2 °C and 40 °C, showing no hysteresis effects between warming and cooling cycles. Although the meander was not shielded against the liquid, the temperature calibration provided equivalent results to low conductive Milli-Q and highly conductive ocean water. The sensor is therefore suitable for inline and online monitoring purposes in recirculating aquaculture systems.}, language = {en} } @article{ZhantlessovaSavitskayaKistaubayevaetal.2024, author = {Zhantlessova, Sirina and Savitskaya, Irina and Kistaubayeva, Aida and Ignatova, Ludmila and Talipova, Aizhan and Pogrebnjak, Alexander and Digel, Ilya}, title = {Correction: Zhantlessova et al. advanced "Green" prebiotic composite of bacterial cellulose/pullulan based on synthetic biology-powered microbial coculture strategy. Polymers 2022, 14, 3224}, series = {Polymers}, volume = {16}, journal = {Polymers}, number = {13}, publisher = {MDPI}, address = {Basel}, issn = {2073-4360}, doi = {10.3390/polym16131802}, pages = {2 Seiten}, year = {2024}, language = {en} } @article{SaretzkiBergmannDahmannetal.2021, author = {Saretzki, Charlotte and Bergmann, Ole and Dahmann, Peter and Janser, Frank and Keimer, Jona and Machado, Patricia and Morrison, Audry and Page, Henry and Pluta, Emil and St{\"u}bing, Felix and K{\"u}pper, Thomas}, title = {Are small airplanes safe with regards to COVID-19 transmission?}, series = {Journal of Travel Medicine}, volume = {28}, journal = {Journal of Travel Medicine}, number = {7}, publisher = {Oxford University Press}, address = {Oxford}, issn = {1708-8305}, doi = {10.1093/jtm/taab105}, year = {2021}, language = {en} } @article{HarrisKleefeld2022, author = {Harris, Isaac and Kleefeld, Andreas}, title = {Analysis and computation of the transmission eigenvalues with a conductive boundary condition}, series = {Applicable Analysis}, volume = {101}, journal = {Applicable Analysis}, number = {6}, publisher = {Taylor \& Francis}, address = {London}, issn = {1563-504X}, doi = {10.1080/00036811.2020.1789598}, pages = {1880 -- 1895}, year = {2022}, abstract = {We provide a new analytical and computational study of the transmission eigenvalues with a conductive boundary condition. These eigenvalues are derived from the scalar inverse scattering problem for an inhomogeneous material with a conductive boundary condition. The goal is to study how these eigenvalues depend on the material parameters in order to estimate the refractive index. The analytical questions we study are: deriving Faber-Krahn type lower bounds, the discreteness and limiting behavior of the transmission eigenvalues as the conductivity tends to infinity for a sign changing contrast. We also provide a numerical study of a new boundary integral equation for computing the eigenvalues. Lastly, using the limiting behavior we will numerically estimate the refractive index from the eigenvalues provided the conductivity is sufficiently large but unknown.}, language = {en} } @article{ZhenLiangStaatetal.2024, author = {Zhen, Manghao and Liang, Yunpei and Staat, Manfred and Li, Quanqui and Li, Jianbo}, title = {Discontinuous fracture behaviors and constitutive model of sandstone specimens containing non-parallel prefabricated fissures under uniaxial compression}, series = {Theoretical and Applied Fracture Mechanics}, volume = {131}, journal = {Theoretical and Applied Fracture Mechanics}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0167-8442}, doi = {10.1016/j.tafmec.2024.104373}, pages = {Artikel 104373}, year = {2024}, abstract = {The deformation and damage laws of non-homogeneous irregular structural planes in rocks are the basis for studying the stability of rock engineering. To investigate the damage characteristics of rock containing non-parallel fissures, uniaxial compression tests and numerical simulations were conducted on sandstone specimens containing three non-parallel fissures inclined at 0°, 45° and 90° in this study. The characteristics of crack initiation and crack evolution of fissures with different inclinations were analyzed. A constitutive model for the discontinuous fractures of fissured sandstone was proposed. The results show that the fracture behaviors of fissured sandstone specimens are discontinuous. The stress-strain curves are non-smooth and can be divided into nonlinear crack closure stage, linear elastic stage, plastic stage and brittle failure stage, of which the plastic stage contains discontinuous stress drops. During the uniaxial compression test, the middle or ends of 0° fissures were the first to crack compared to 45° and 90° fissures. The end with small distance between 0° and 45° fissures cracked first, and the end with large distance cracked later. After the final failure, 0° fissures in all specimens were fractured, while 45° and 90° fissures were not necessarily fractured. Numerical simulation results show that the concentration of compressive stress at the tips of 0°, 45° and 90° fissures, as well as the concentration of tensile stress on both sides, decreased with the increase of the inclination angle. A constitutive model for the discontinuous fractures of fissured sandstone specimens was derived by combining the logistic model and damage mechanic theory. This model can well describe the discontinuous drops of stress and agrees well with the whole processes of the stress-strain curves of the fissured sandstone specimens.}, language = {en} } @article{DiktaReisselHarlass2016, author = {Dikta, Gerhard and Reißel, Martin and Harlaß, Carsten}, title = {Semi-parametric survival function estimators deduced from an identifying Volterra type integral equation}, series = {Journal of multivariate analysis}, journal = {Journal of multivariate analysis}, number = {147}, publisher = {Elsevier}, address = {Amsterdam}, doi = {10.1016/j.jmva.2016.02.008}, pages = {273 -- 284}, year = {2016}, abstract = {Based on an identifying Volterra type integral equation for randomly right censored observations from a lifetime distribution function F, we solve the corresponding estimating equation by an explicit and implicit Euler scheme. While the first approach results in some known estimators, the second one produces new semi-parametric and pre-smoothed Kaplan-Meier estimators which are real distribution functions rather than sub-distribution functions as the former ones are. This property of the new estimators is particular useful if one wants to estimate the expected lifetime restricted to the support of the observation time. Specifically, we focus on estimation under the semi-parametric random censorship model (SRCM), that is, a random censorship model where the conditional expectation of the censoring indicator given the observation belongs to a parametric family. We show that some estimated linear functionals which are based on the new semi-parametric estimator are strong consistent, asymptotically normal, and efficient under SRCM. In a small simulation study, the performance of the new estimator is illustrated under moderate sample sizes. Finally, we apply the new estimator to a well-known real dataset.}, language = {en} } @article{MichaelMayerWeberetal.2017, author = {Michael, Hackl and Mayer, Katharina and Weber, Mareike and Staat, Manfred and van Riet, Roger and Burkhart, Klau Josef and M{\"u}ller, Lars Peter and Wegmann, Kilian}, title = {Plate osteosynthesis of proximal ulna fractures : a biomechanical micromotion analysis}, series = {The journal of hand surgery}, volume = {42}, journal = {The journal of hand surgery}, number = {10}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0363-5023}, doi = {10.1016/j.jhsa.2017.05.014}, pages = {834.e1 -- 834.e7}, year = {2017}, language = {en} } @article{SalpatiChuChenetal.2014, author = {Salpati, Laurent and Chu, Xiaoyan and Chen, Liangfu and Prasad, Bhagwat and Dallas, Shannon and Evers, Raymond and Mamaril-Fishman, Donna and Geier, Ethan G. and Kehler, Jonathan and Kunta, Jeevan and Mezler, Mario and Laplanche, Loic and Pang, Jodie and Soars, Matthew G. and Unadkat, Jashvant D. and van Waterschoot, Robert A.B. and Yabut, Jocelyn and Schinkel, Alfred H. and Scheer, Nico and Rode, Anja}, title = {Evaluation of organic anion transporting polypeptide 1B1 and 1B3 humanized mice as a translational model to study the pharmacokinetics of statins}, series = {Drug Metabolism and Disposition}, volume = {42}, journal = {Drug Metabolism and Disposition}, number = {8}, publisher = {ASPET}, address = {Bethesda, Md.}, issn = {1521-009X}, doi = {10.1124/dmd.114.057976}, pages = {1301 -- 1313}, year = {2014}, abstract = {Organic anion transporting polypeptide (Oatp) 1a/1b knockout and OATP1B1 and -1B3 humanized mouse models are promising tools for studying the roles of these transporters in drug disposition. Detailed characterization of these models will help to better understand their utility for predicting clinical outcomes. To advance this approach, we carried out a comprehensive analysis of these mouse lines by evaluating the compensatory changes in mRNA expression, quantifying the amounts of OATP1B1 and -1B3 protein by liquid chromatography-tandem mass spectrometry, and studying the active uptake in isolated hepatocytes and the pharmacokinetics of some prototypical substrates including statins. Major outcomes from these studies were 1) mostly moderate compensatory changes in only a few genes involved in drug metabolism and disposition, 2) a robust hepatic expression of OATP1B1 and -1B3 proteins in the respective humanized mouse models, and 3) functional activities of the human transporters in hepatocytes isolated from the humanized models with several substrates tested in vitro and with pravastatin in vivo. However, the expression of OATP1B1 and -1B3 in the humanized models did not significantly alter liver or plasma concentrations of rosuvastatin and pitavastatin compared with Oatp1a/1b knockout controls under the conditions used in our studies. Hence, although the humanized OATP1B1 and -1B3 mice showed in vitro and/or in vivo functional activity with some statins, further characterization of these models is required to define their potential use and limitations in the prediction of drug disposition and drug-drug interactions in humans.}, language = {en} } @article{WeldenPoghossianVahidpouretal.2022, author = {Welden, Melanie and Poghossian, Arshak and Vahidpour, Farnoosh and Wendlandt, Tim and Keusgen, Michael and Wege, Christina and Sch{\"o}ning, Michael Josef}, title = {Towards multi-analyte detection with field-effect capacitors modified with tobacco mosaic virus bioparticles as enzyme nanocarriers}, series = {Biosensors}, volume = {12}, journal = {Biosensors}, number = {1}, publisher = {MDPI}, address = {Basel}, issn = {2079-6374}, doi = {10.3390/bios12010043}, pages = {Artikel 43}, year = {2022}, abstract = {Utilizing an appropriate enzyme immobilization strategy is crucial for designing enzyme-based biosensors. Plant virus-like particles represent ideal nanoscaffolds for an extremely dense and precise immobilization of enzymes, due to their regular shape, high surface-to-volume ratio and high density of surface binding sites. In the present work, tobacco mosaic virus (TMV) particles were applied for the co-immobilization of penicillinase and urease onto the gate surface of a field-effect electrolyte-insulator-semiconductor capacitor (EISCAP) with a p-Si-SiO₂-Ta₂O₅ layer structure for the sequential detection of penicillin and urea. The TMV-assisted bi-enzyme EISCAP biosensor exhibited a high urea and penicillin sensitivity of 54 and 85 mV/dec, respectively, in the concentration range of 0.1-3 mM. For comparison, the characteristics of single-enzyme EISCAP biosensors modified with TMV particles immobilized with either penicillinase or urease were also investigated. The surface morphology of the TMV-modified Ta₂O₅-gate was analyzed by scanning electron microscopy. Additionally, the bi-enzyme EISCAP was applied to mimic an XOR (Exclusive OR) enzyme logic gate.}, language = {en} } @article{ClausnitzerKleefeld2024, author = {Clausnitzer, Julian and Kleefeld, Andreas}, title = {A spectral Galerkin exponential Euler time-stepping scheme for parabolic SPDEs on two-dimensional domains with a C² boundary}, series = {Discrete and Continuous Dynamical Systems - Series B}, volume = {29}, journal = {Discrete and Continuous Dynamical Systems - Series B}, number = {4}, publisher = {AIMS}, address = {Springfield}, issn = {1531-3492}, doi = {10.3934/dcdsb.2023148}, pages = {1624 -- 1651}, year = {2024}, abstract = {We consider the numerical approximation of second-order semi-linear parabolic stochastic partial differential equations interpreted in the mild sense which we solve on general two-dimensional domains with a C² boundary with homogeneous Dirichlet boundary conditions. The equations are driven by Gaussian additive noise, and several Lipschitz-like conditions are imposed on the nonlinear function. We discretize in space with a spectral Galerkin method and in time using an explicit Euler-like scheme. For irregular shapes, the necessary Dirichlet eigenvalues and eigenfunctions are obtained from a boundary integral equation method. This yields a nonlinear eigenvalue problem, which is discretized using a boundary element collocation method and is solved with the Beyn contour integral algorithm. We present an error analysis as well as numerical results on an exemplary asymmetric shape, and point out limitations of the approach.}, language = {en} } @article{MartinVaqueroKleefeld2020, author = {Mart{\´i}n-Vaquero, J. and Kleefeld, Andreas}, title = {Solving nonlinear parabolic PDEs in several dimensions: Parallelized ESERK codes}, series = {Journal of Computational Physics}, journal = {Journal of Computational Physics}, number = {423}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0021-9991}, doi = {10.1016/j.jcp.2020.109771}, year = {2020}, abstract = {There is a very large number of very important situations which can be modeled with nonlinear parabolic partial differential equations (PDEs) in several dimensions. In general, these PDEs can be solved by discretizing in the spatial variables and transforming them into huge systems of ordinary differential equations (ODEs), which are very stiff. Therefore, standard explicit methods require a large number of iterations to solve stiff problems. But implicit schemes are computationally very expensive when solving huge systems of nonlinear ODEs. Several families of Extrapolated Stabilized Explicit Runge-Kutta schemes (ESERK) with different order of accuracy (3 to 6) are derived and analyzed in this work. They are explicit methods, with stability regions extended, along the negative real semi-axis, quadratically with respect to the number of stages s, hence they can be considered to solve stiff problems much faster than traditional explicit schemes. Additionally, they allow the adaptation of the step length easily with a very small cost. Two new families of ESERK schemes (ESERK3 and ESERK6) are derived, and analyzed, in this work. Each family has more than 50 new schemes, with up to 84.000 stages in the case of ESERK6. For the first time, we also parallelized all these new variable step length and variable number of stages algorithms (ESERK3, ESERK4, ESERK5, and ESERK6). These parallelized strategies allow to decrease times significantly, as it is discussed and also shown numerically in two problems. Thus, the new codes provide very good results compared to other well-known ODE solvers. Finally, a new strategy is proposed to increase the efficiency of these schemes, and it is discussed the idea of combining ESERK families in one code, because typically, stiff problems have different zones and according to them and the requested tolerance the optimum order of convergence is different.}, language = {en} } @article{FingerBraunBil2018, author = {Finger, Felix and Braun, Carsten and Bil, Cees}, title = {Impact of electric propulsion technology and mission requirements on the performance of VTOL UAVs}, series = {CEAS Aeronautical Journal}, volume = {10}, journal = {CEAS Aeronautical Journal}, number = {3}, publisher = {Springer}, issn = {1869-5582 print}, doi = {10.1007/s13272-018-0352-x}, pages = {843}, year = {2018}, abstract = {One of the engineering challenges in aviation is the design of transitioning vertical take-off and landing (VTOL) aircraft. Thrust-borne flight implies a higher mass fraction of the propulsion system, as well as much increased energy consumption in the take-off and landing phases. This mass increase is typically higher for aircraft with a separate lift propulsion system than for aircraft that use the cruise propulsion system to support a dedicated lift system. However, for a cost-benefit trade study, it is necessary to quantify the impact the VTOL requirement and propulsion configuration has on aircraft mass and size. For this reason, sizing studies are conducted. This paper explores the impact of considering a supplemental electric propulsion system for achieving hovering flight. Key variables in this study, apart from the lift system configuration, are the rotor disk loading and hover flight time, as well as the electrical systems technology level for both batteries and motors. Payload and endurance are typically used as the measures of merit for unmanned aircraft that carry electro-optical sensors, and therefore the analysis focuses on these particular parameters.}, language = {en} }