@article{BiewendtBoehnertBlaschke2020, author = {Biewendt, Marcel and B{\"o}hnert, Arno and Blaschke, Florian}, title = {The repercussions of the digital twin in the automotive industry on the new marketing logic}, series = {European Journal of Marketing and Economics}, volume = {4}, journal = {European Journal of Marketing and Economics}, number = {1}, publisher = {Revistia}, address = {London}, issn = {2601-8659}, doi = {10.26417/229eim64f}, pages = {68 -- 73}, year = {2020}, abstract = {Rapid development of virtual and data acquisition technology makes Digital Twin Technology (DT) one of the fundamental areas of research, while DT is one of the most promissory developments for the achievement of Industry 4.0. 48\% percent of organisations implementing the Internet of Things are already using DT or plan to use DT in 2020. The global market for DT is expected to grow by 38 percent annually, reaching USD16 billion by 2023. In addition, the number of participating organisations using digital twins is expected to triple by 2022. DTs are characterised by the integration between physical and virtual spaces. The driving idea for DT is to develop, test and build our devices in a virtual environment. The objective of this paper is to study the impact of DT in the automotive industry on the new marketing logic. This paper outlines the current challenges and possible directions for the future DT in marketing. This paper will be helpful for managers in the industry to use the advantages and potentials of DT.}, language = {en} } @article{BaringhausGaigall2017, author = {Baringhaus, Ludwig and Gaigall, Daniel}, title = {On Hotelling's T² test in a special paired sample case}, series = {Communications in Statistics - Theory and Methods}, volume = {48}, journal = {Communications in Statistics - Theory and Methods}, number = {2}, publisher = {Taylor \& Francis}, address = {London}, issn = {1532-415X}, doi = {10.1080/03610926.2017.1408828}, pages = {257 -- 267}, year = {2017}, abstract = {In a special paired sample case, Hotelling's T² test based on the differences of the paired random vectors is the likelihood ratio test for testing the hypothesis that the paired random vectors have the same mean; with respect to a special group of affine linear transformations it is the uniformly most powerful invariant test for the general alternative of a difference in mean. We present an elementary straightforward proof of this result. The likelihood ratio test for testing the hypothesis that the covariance structure is of the assumed special form is derived and discussed. Applications to real data are given.}, language = {en} } @article{LuisierLempiaeinenScherbichleretal.2014, author = {Luisier, Rapha{\"e}lle and Lempi{\"a}inen, Harri and Scherbichler, Nina and Braeuning, Albert and Geissler, Miriam and Dubost, Valerie and M{\"u}ller, Arne and Scheer, Nico and Chibout, Salah-Dine and Hara, Hisanori and Picard, Frank and Theil, Diethilde and Couttet, Philippe and Vitobello, Antonio and Grenet, Olivier and Grasl-Kraupp, Bettina and Ellinger-Ziegelbauer, Heidrung and Thomson, John P. and Meehan, Richard R. and Elcombe, Clifford R. and Henderson, Colin J. and Wolf, C. Roland and Schwarz, Michael and Moulin, Pierre and Terranova, Remi and Moggs, Jonathan G.}, title = {Phenobarbital Induces Cell Cycle Transcriptional Responses in Mouse Liver Humanized for Constitutive Androstane and Pregnane X Receptors}, series = {Toxicological Sciences}, volume = {139}, journal = {Toxicological Sciences}, number = {2}, publisher = {Oxford University Press}, address = {Oxford}, issn = {1094-2025}, doi = {https://doi.org/10.1093/toxsci/kfu038}, pages = {501 -- 511}, year = {2014}, abstract = {The constitutive androstane receptor (CAR) and the pregnane X receptor (PXR) are closely related nuclear receptors involved in drug metabolism and play important roles in the mechanism of phenobarbital (PB)-induced rodent nongenotoxic hepatocarcinogenesis. Here, we have used a humanized CAR/PXR mouse model to examine potential species differences in receptor-dependent mechanisms underlying liver tissue molecular responses to PB. Early and late transcriptomic responses to sustained PB exposure were investigated in liver tissue from double knock-out CAR and PXR (CARᴷᴼ-PXRᴷᴼ), double humanized CAR and PXR (CARʰ-PXRʰ), and wild-type C57BL/6 mice. Wild-type and CARʰ-PXRʰ mouse livers exhibited temporally and quantitatively similar transcriptional responses during 91 days of PB exposure including the sustained induction of the xenobiotic response gene Cyp2b10, the Wnt signaling inhibitor Wisp1, and noncoding RNA biomarkers from the Dlk1-Dio3 locus. Transient induction of DNA replication (Hells, Mcm6, and Esco2) and mitotic genes (Ccnb2, Cdc20, and Cdk1) and the proliferation-related nuclear antigen Mki67 were observed with peak expression occurring between 1 and 7 days PB exposure. All these transcriptional responses were absent in CARᴷᴼ-PXRᴷᴼ mouse livers and largely reversible in wild-type and CARʰ-PXRʰ mouse livers following 91 days of PB exposure and a subsequent 4-week recovery period. Furthermore, PB-mediated upregulation of the noncoding RNA Meg3, which has recently been associated with cellular pluripotency, exhibited a similar dose response and perivenous hepatocyte-specific localization in both wild-type and CARʰ-PXRʰ mice. Thus, mouse livers coexpressing human CAR and PXR support both the xenobiotic metabolizing and the proliferative transcriptional responses following exposure to PB.}, language = {en} } @article{BlockViebahnJungbluth2024, author = {Block, Simon and Viebahn, Peter and Jungbluth, Christian}, title = {Analysing direct air capture for enabling negative emissions in Germany: an assessment of the resource requirements and costs of a potential rollout in 2045}, series = {Frontiers in Climate}, volume = {6}, journal = {Frontiers in Climate}, publisher = {Frontiers}, address = {Lausanne}, issn = {2624-9553}, doi = {10.3389/fclim.2024.1353939}, pages = {18 Seiten}, year = {2024}, abstract = {Direct air capture (DAC) combined with subsequent storage (DACCS) is discussed as one promising carbon dioxide removal option. The aim of this paper is to analyse and comparatively classify the resource consumption (land use, renewable energy and water) and costs of possible DAC implementation pathways for Germany. The paths are based on a selected, existing climate neutrality scenario that requires the removal of 20 Mt of carbon dioxide (CO2) per year by DACCS from 2045. The analysis focuses on the so-called "low-temperature" DAC process, which might be more advantageous for Germany than the "high-temperature" one. In four case studies, we examine potential sites in northern, central and southern Germany, thereby using the most suitable renewable energies for electricity and heat generation. We show that the deployment of DAC results in large-scale land use and high energy needs. The land use in the range of 167-353 km2 results mainly from the area required for renewable energy generation. The total electrical energy demand of 14.4 TWh per year, of which 46\% is needed to operate heat pumps to supply the heat demand of the DAC process, corresponds to around 1.4\% of Germany's envisaged electricity demand in 2045. 20 Mt of water are provided yearly, corresponding to 40\% of the city of Cologne's water demand (1.1 million inhabitants). The capture of CO2 (DAC) incurs levelised costs of 125-138 EUR per tonne of CO2, whereby the provision of the required energy via photovoltaics in southern Germany represents the lowest value of the four case studies. This does not include the costs associated with balancing its volatility. Taking into account transporting the CO2 via pipeline to the port of Wilhelmshaven, followed by transporting and sequestering the CO2 in geological storage sites in the Norwegian North Sea (DACCS), the levelised costs increase to 161-176 EUR/tCO2. Due to the longer transport distances from southern and central Germany, a northern German site using wind turbines would be the most favourable.}, language = {en} } @article{BhattaraiStaat2018, author = {Bhattarai, Aroj and Staat, Manfred}, title = {Computational comparison of different textile implants to correct apical prolapse in females}, series = {Current Directions in Biomedical Engineering}, volume = {4}, journal = {Current Directions in Biomedical Engineering}, number = {1}, publisher = {De Gruyter}, address = {Berlin}, doi = {10.1515/cdbme-2018-0159}, pages = {661 -- 664}, year = {2018}, abstract = {Prosthetic textile implants of different shapes, sizes and polymers are used to correct the apical prolapse after hysterectomy (removal of the uterus). The selection of the implant before or during minimally invasive surgery depends on the patient's anatomical defect, intended function after reconstruction and most importantly the surgeon's preference. Weakness or damage of the supporting tissues during childbirth, menopause or previous pelvic surgeries may put females in higher risk of prolapse. Numerical simulations of reconstructed pelvic floor with weakened tissues and organ supported by textile product models: DynaMesh®-PRS soft, DynaMesh®-PRP soft and DynaMesh®-CESA from FEG Textiletechnik mbH, Germany are compared.}, language = {en} } @article{BragardConradvanHoeketal.2011, author = {Bragard, Michael and Conrad, M. and van Hoek, H. and De Doncker, R. W.}, title = {The integrated emitter turn-off thyristor (IETO) : an innovative thyristor-based high power semiconductor device using MOS assisted turn-off}, series = {IEEE transactions on industry applications}, volume = {47}, journal = {IEEE transactions on industry applications}, number = {5}, publisher = {IEEE}, address = {New York}, issn = {0093-9994}, doi = {10.1109/TIA.2011.2161432}, pages = {2175 -- 2182}, year = {2011}, language = {en} } @article{ScheerMclaughlinRodeetal.2014, author = {Scheer, Nico and Mclaughlin, Lesley A. and Rode, Anja and MacLeod, Alastair Kenneth and Henderson, Colin J. and Wolf, Roland C.}, title = {Deletion of thirty murine cytochrome P450 genes results in viable mice with compromised drug metabolism}, series = {Drug Metabolism and Disposition}, volume = {42}, journal = {Drug Metabolism and Disposition}, number = {6}, publisher = {ASPET}, address = {Bethesda, Md.}, issn = {1521-009X}, doi = {10.1124/dmd.114.057885}, pages = {1022 -- 1030}, year = {2014}, abstract = {In humans, 75\% of all drugs are metabolized by the cytochrome P450-dependent monooxygenase system. Enzymes encoded by the CYP2C, CYP2D, and CYP3A gene clusters account for ∼80\% of this activity. There are profound species differences in the multiplicity of cytochrome P450 enzymes, and the use of mouse models to predict pathways of drug metabolism is further complicated by overlapping substrate specificity between enzymes from different gene families. To establish the role of the hepatic and extrahepatic P450 system in drug and foreign chemical disposition, drug efficacy, and toxicity, we created a unique mouse model in which 30 cytochrome P450 genes from the Cyp2c, Cyp2d, and Cyp3a gene clusters have been deleted. Remarkably, despite a wide range of putative important endogenous functions, Cyp2c/2d/3a KO mice were viable and fertile, demonstrating that these genes have evolved primarily as detoxification enzymes. Although there was no overt phenotype, detailed examination showed Cyp2c/2d/3a KO mice had a smaller body size (15\%) and larger livers (20\%). Changes in hepatic morphology and a decreased blood glucose (30\%) were also noted. A five-drug cocktail of cytochrome P450 isozyme probe substrates were used to evaluate changes in drug pharmacokinetics; marked changes were observed in either the pharmacokinetics or metabolites formed from Cyp2c, Cyp2d, and Cyp3a substrates, whereas the metabolism of the Cyp1a substrate caffeine was unchanged. Thus, Cyp2c/2d/3a KO mice provide a powerful model to study the in vivo role of the P450 system in drug metabolism and efficacy, as well as in chemical toxicity.}, language = {en} } @article{Kleefeld2021, author = {Kleefeld, Andreas}, title = {The hot spots conjecture can be false: some numerical examples}, series = {Advances in Computational Mathematics}, volume = {47}, journal = {Advances in Computational Mathematics}, publisher = {Springer}, address = {Dordrecht}, issn = {1019-7168}, doi = {10.1007/s10444-021-09911-5}, year = {2021}, abstract = {The hot spots conjecture is only known to be true for special geometries. This paper shows numerically that the hot spots conjecture can fail to be true for easy to construct bounded domains with one hole. The underlying eigenvalue problem for the Laplace equation with Neumann boundary condition is solved with boundary integral equations yielding a non-linear eigenvalue problem. Its discretization via the boundary element collocation method in combination with the algorithm by Beyn yields highly accurate results both for the first non-zero eigenvalue and its corresponding eigenfunction which is due to superconvergence. Additionally, it can be shown numerically that the ratio between the maximal/minimal value inside the domain and its maximal/minimal value on the boundary can be larger than 1 + 10- 3. Finally, numerical examples for easy to construct domains with up to five holes are provided which fail the hot spots conjecture as well.}, language = {en} } @article{ScheerHendersonKapelyukhetal.2019, author = {Scheer, Nico and Henderson, Colin James and Kapelyukh, Yury and Rode, Anja and Mclaren, Aileen W. and MacLeod, Alastair Kenneth and Lin, De and Wright, Jayne and Stanley, Lesley and Wolf, C. Roland}, title = {An extensively humanised mouse model to predict pathways of drug disposition, drug/drug interactions, and to facilitate the design of clinical trials}, series = {Drug Metabolism and Disposition}, journal = {Drug Metabolism and Disposition}, number = {Early view}, doi = {10.1124/dmd.119.086397}, pages = {69 Seiten}, year = {2019}, language = {en} } @article{GossmannFrotscherLinderetal.2016, author = {Goßmann, Matthias and Frotscher, Ralf and Linder, Peter and Bayer, Robin and Epple, U. and Staat, Manfred and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard}, title = {Mechano-pharmacological characterization of cardiomyocytes derived from human induced pluripotent stem cells}, series = {Cellular physiology and biochemistry}, volume = {38}, journal = {Cellular physiology and biochemistry}, number = {3}, publisher = {Karger}, address = {Basel}, issn = {1421-9778 (Online)}, doi = {10.1159/000443124}, pages = {1182 -- 1198}, year = {2016}, abstract = {Background/Aims: Common systems for the quantification of cellular contraction rely on animal-based models, complex experimental setups or indirect approaches. The herein presented CellDrum technology for testing mechanical tension of cellular monolayers and thin tissue constructs has the potential to scale-up mechanical testing towards medium-throughput analyses. Using hiPS-Cardiac Myocytes (hiPS-CMs) it represents a new perspective of drug testing and brings us closer to personalized drug medication. Methods: In the present study, monolayers of self-beating hiPS-CMs were grown on ultra-thin circular silicone membranes and deflect under the weight of the culture medium. Rhythmic contractions of the hiPS-CMs induced variations of the membrane deflection. The recorded contraction-relaxation-cycles were analyzed with respect to their amplitudes, durations, time integrals and frequencies. Besides unstimulated force and tensile stress, we investigated the effects of agonists and antagonists acting on Ca²⁺ channels (S-Bay K8644/verapamil) and Na⁺ channels (veratridine/lidocaine). Results: The measured data and simulations for pharmacologically unstimulated contraction resembled findings in native human heart tissue, while the pharmacological dose-response curves were highly accurate and consistent with reference data. Conclusion: We conclude that the combination of the CellDrum with hiPS-CMs offers a fast, facile and precise system for pharmacological, toxicological studies and offers new preclinical basic research potential.}, language = {en} } @article{BertzMolinnusSchoeningetal.2023, author = {Bertz, Morten and Molinnus, Denise and Sch{\"o}ning, Michael Josef and Homma, Takayuki}, title = {Real-time monitoring of H₂O₂ sterilization on individual bacillus atrophaeus spores by optical sensing with trapping Raman spectroscopy}, series = {Chemosensors}, volume = {8}, journal = {Chemosensors}, number = {11}, publisher = {MDPI}, address = {Basel}, issn = {2227-9040}, doi = {10.3390/chemosensors11080445}, pages = {Artikel 445}, year = {2023}, abstract = {Hydrogen peroxide (H₂O₂), a strong oxidizer, is a commonly used sterilization agent employed during aseptic food processing and medical applications. To assess the sterilization efficiency with H₂O₂, bacterial spores are common microbial systems due to their remarkable robustness against a wide variety of decontamination strategies. Despite their widespread use, there is, however, only little information about the detailed time-resolved mechanism underlying the oxidative spore death by H₂O₂. In this work, we investigate chemical and morphological changes of individual Bacillus atrophaeus spores undergoing oxidative damage using optical sensing with trapping Raman microscopy in real-time. The time-resolved experiments reveal that spore death involves two distinct phases: (i) an initial phase dominated by the fast release of dipicolinic acid (DPA), a major spore biomarker, which indicates the rupture of the spore's core; and (ii) the oxidation of the remaining spore material resulting in the subsequent fragmentation of the spores' coat. Simultaneous observation of the spore morphology by optical microscopy corroborates these mechanisms. The dependence of the onset of DPA release and the time constant of spore fragmentation on H₂O₂ shows that the formation of reactive oxygen species from H₂O₂ is the rate-limiting factor of oxidative spore death.}, language = {en} } @article{ThiebesKleinZingsheimetal.2022, author = {Thiebes, Anja Lena and Klein, Sarah and Zingsheim, Jonas and M{\"o}ller, Georg H. and G{\"u}rzing, Stefanie and Reddemann, Manuel A. and Behbahani, Mehdi and Cornelissen, Christian G.}, title = {Effervescent atomizer as novel cell spray technology to decrease the gas-to-liquid ratio}, series = {pharmaceutics}, volume = {14}, journal = {pharmaceutics}, number = {11}, publisher = {MDPI}, address = {Basel}, doi = {10.3390/pharmaceutics14112421}, pages = {Artikel 2421}, year = {2022}, abstract = {Cell spraying has become a feasible application method for cell therapy and tissue engineering approaches. Different devices have been used with varying success. Often, twin-fluid atomizers are used, which require a high gas velocity for optimal aerosolization characteristics. To decrease the amount and velocity of required air, a custom-made atomizer was designed based on the effervescent principle. Different designs were evaluated regarding spray characteristics and their influence on human adipose-derived mesenchymal stromal cells. The arithmetic mean diameters of the droplets were 15.4-33.5 µm with decreasing diameters for increasing gas-to-liquid ratios. The survival rate was >90\% of the control for the lowest gas-to-liquid ratio. For higher ratios, cell survival decreased to approximately 50\%. Further experiments were performed with the design, which had shown the highest survival rates. After seven days, no significant differences in metabolic activity were observed. The apoptosis rates were not influenced by aerosolization, while high gas-to-liquid ratios caused increased necrosis levels. Tri-lineage differentiation potential into adipocytes, chondrocytes, and osteoblasts was not negatively influenced by aerosolization. Thus, the effervescent aerosolization principle was proven suitable for cell applications requiring reduced amounts of supplied air. This is the first time an effervescent atomizer was used for cell processing.}, language = {en} } @article{BreussKleefeld2020, author = {Breuß, Michael and Kleefeld, Andreas}, title = {Implicit monotone difference methods for scalar conservation laws with source terms}, series = {Acta Mathematica Vietnamica}, volume = {45}, journal = {Acta Mathematica Vietnamica}, publisher = {Springer Singapore}, address = {Singapore}, issn = {2315-4144}, doi = {10.1007/s40306-019-00354-1}, pages = {709 -- 738}, year = {2020}, abstract = {In this article, a concept of implicit methods for scalar conservation laws in one or more spatial dimensions allowing also for source terms of various types is presented. This material is a significant extension of previous work of the first author (Breuß SIAM J. Numer. Anal. 43(3), 970-986 2005). Implicit notions are developed that are centered around a monotonicity criterion. We demonstrate a connection between a numerical scheme and a discrete entropy inequality, which is based on a classical approach by Crandall and Majda. Additionally, three implicit methods are investigated using the developed notions. Next, we conduct a convergence proof which is not based on a classical compactness argument. Finally, the theoretical results are confirmed by various numerical tests.}, language = {en} } @article{Gaigall2020, author = {Gaigall, Daniel}, title = {Hoeffding-Blum-Kiefer-Rosenblatt independence test statistic on partly not identically distributed data}, series = {Communications in Statistics - Theory and Methods}, volume = {51}, journal = {Communications in Statistics - Theory and Methods}, number = {12}, publisher = {Taylor \& Francis}, address = {London}, issn = {1532-415X}, doi = {10.1080/03610926.2020.1805767}, pages = {4006 -- 4028}, year = {2020}, abstract = {The established Hoeffding-Blum-Kiefer-Rosenblatt independence test statistic is investigated for partly not identically distributed data. Surprisingly, it turns out that the statistic has the well-known distribution-free limiting null distribution of the classical criterion under standard regularity conditions. An application is testing goodness-of-fit for the regression function in a non parametric random effects meta-regression model, where the consistency is obtained as well. Simulations investigate size and power of the approach for small and moderate sample sizes. A real data example based on clinical trials illustrates how the test can be used in applications.}, language = {en} } @article{BaaderBoxbergChenetal.2023, author = {Baader, Fabian and Boxberg, Marc S. and Chen, Qian and F{\"o}rstner, Roger and Kowalski, Julia and Dachwald, Bernd}, title = {Field-test performance of an ice-melting probe in a terrestrial analogue environment}, series = {Icarus}, journal = {Icarus}, number = {409}, publisher = {Elsevier}, address = {Amsterdam}, doi = {10.1016/j.icarus.2023.115852}, pages = {Artikel 115852}, year = {2023}, abstract = {Melting probes are a proven tool for the exploration of thick ice layers and clean sampling of subglacial water on Earth. Their compact size and ease of operation also make them a key technology for the future exploration of icy moons in our Solar System, most prominently Europa and Enceladus. For both mission planning and hardware engineering, metrics such as efficiency and expected performance in terms of achievable speed, power requirements, and necessary heating power have to be known. Theoretical studies aim at describing thermal losses on the one hand, while laboratory experiments and field tests allow an empirical investigation of the true performance on the other hand. To investigate the practical value of a performance model for the operational performance in extraterrestrial environments, we first contrast measured data from terrestrial field tests on temperate and polythermal glaciers with results from basic heat loss models and a melt trajectory model. For this purpose, we propose conventions for the determination of two different efficiencies that can be applied to both measured data and models. One definition of efficiency is related to the melting head only, while the other definition considers the melting probe as a whole. We also present methods to combine several sources of heat loss for probes with a circular cross-section, and to translate the geometry of probes with a non-circular cross-section to analyse them in the same way. The models were selected in a way that minimizes the need to make assumptions about unknown parameters of the probe or the ice environment. The results indicate that currently used models do not yet reliably reproduce the performance of a probe under realistic conditions. Melting velocities and efficiencies are constantly overestimated by 15 to 50 \% in the models, but qualitatively agree with the field test data. Hence, losses are observed, that are not yet covered and quantified by the available loss models. We find that the deviation increases with decreasing ice temperature. We suspect that this mismatch is mainly due to the too restrictive idealization of the probe model and the fact that the probe was not operated in an efficiency-optimized manner during the field tests. With respect to space mission engineering, we find that performance and efficiency models must be used with caution in unknown ice environments, as various ice parameters have a significant effect on the melting process. Some of these are difficult to estimate from afar.}, language = {en} } @article{WilsonWilsonScheeretal.2017, author = {Wilson, Ian D. and Wilson, Claire E. and Scheer, Nico and Dickie, A.P. and Schreiter, K. and Wilson, E. M. and Riley, R. J. and Wehr, R. and Bial, J.}, title = {The Pharmacokinetics and Metabolism of Lumiracoxib in Chimeric Humanized and Murinized FRG Mice}, series = {Biochemical pharmacology}, volume = {Volume 135}, journal = {Biochemical pharmacology}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1873-2968}, doi = {10.1016/j.bcp.2017.03.015}, pages = {139 -- 150}, year = {2017}, language = {en} } @article{HoughNalwalkDingetal.2015, author = {Hough, Lindsay B. and Nalwalk, Julia W. and Ding, Xinxin and Scheer, Nico}, title = {Opioid Analgesia in P450 Gene Cluster Knockout Mice: A Search for Analgesia-Relevant Isoforms}, series = {Drug Metabolism and Disposition}, volume = {43}, journal = {Drug Metabolism and Disposition}, number = {9}, issn = {1521-009x}, doi = {10.1124/dmd.115.065490}, pages = {1326 -- 1330}, year = {2015}, language = {en} } @article{RuppSchulzeKuperjans2018, author = {Rupp, Matthias and Schulze, Sven and Kuperjans, Isabel}, title = {Comparative life cycle analysis of conventional and hybrid heavy-duty trucks}, series = {World electric vehicle journal}, volume = {9}, journal = {World electric vehicle journal}, number = {2}, publisher = {MDPI}, address = {Basel}, issn = {2032-6653}, doi = {10.3390/wevj9020033}, pages = {Article No. 33}, year = {2018}, abstract = {Heavy-duty trucks are one of the main contributors to greenhouse gas emissions in German traffic. Drivetrain electrification is an option to reduce tailpipe emissions by increasing energy conversion efficiency. To evaluate the vehicle's environmental impacts, it is necessary to consider the entire life cycle. In addition to the daily use, it is also necessary to include the impact of production and disposal. This study presents the comparative life cycle analysis of a parallel hybrid and a conventional heavy-duty truck in long-haul operation. Assuming a uniform vehicle glider, only the differing parts of both drivetrains are taken into account to calculate the environmental burdens of the production. The use phase is modeled by a backward simulation in MATLAB/Simulink considering a characteristic driving cycle. A break-even analysis is conducted to show at what mileage the larger CO2eq emissions due to the production of the electric drivetrain are compensated. The effect of parameter variation on the break-even mileage is investigated by a sensitivity analysis. The results of this analysis show the difference in CO2eq/t km is negative, indicating that the hybrid vehicle releases 4.34 g CO2eq/t km over a lifetime fewer emissions compared to the diesel truck. The break-even analysis also emphasizes the advantages of the electrified drivetrain, compensating the larger emissions generated during production after already a distance of 15,800 km (approx. 1.5 months of operation time). The intersection coordinates, distance, and CO2eq, strongly depend on fuel, emissions for battery production and the driving profile, which lead to nearly all parameter variations showing an increase in break-even distance.}, language = {en} } @article{KobFrauenrath2009, author = {Kob, Malte and Frauenrath, Tobias}, title = {A system for parallel measurement of glottis opening and larynx position}, series = {Biomedical Signal Processing and Control}, volume = {4}, journal = {Biomedical Signal Processing and Control}, number = {3}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1746-8108}, doi = {10.1016/j.bspc.2009.03.004}, pages = {221 -- 228}, year = {2009}, abstract = {The simultaneous assessment of glottal dynamics and larynx position can be beneficial for the diagnosis of disordered voice or speech production and swallowing. Up to now, methods either concentrate on assessment of the glottis opening using optical, acoustical or electrical (electroglottography, EGG) methods, or on visualisation of the larynx position using ultrasound, computer tomography or magnetic resonance imaging techniques. The method presented here makes use of a time-multiplex measurement approach of space-resolved transfer impedances through the larynx. The fast sequence of measurements allows a quasi simultaneous assessment of both larynx position and EGG signal using up to 32 transmit-receive signal paths. The system assesses the dynamic opening status of the glottis as well as the vertical and back/forward motion of the larynx. Two electrode-arrays are used for the measurement of the electrical transfer impedance through the neck in different directions. From the acquired data the global and individual conductivity is calculated as well as a 2D point spatial representation of the minimum impedance. The position information is shown together with classical EGG signals allowing a synchronous visual assessment of glottal area and larynx position. A first application to singing voice analysis is presented that indicate a high potential of the method for use as a non-invasive tool in the diagnosis of voice, speech, and swallowing disorders.}, language = {en} } @article{MuesgenanntKoersMcNeilRadchenkoetal.2023, author = {Mues genannt Koers, Lucas and McNeil, S. W. and Radchenko, V. and Paulßen, Elisabeth and Hoehr, Cornelia}, title = {Production of Co-58m in a siphon-style liquid target on a medical cyclotron}, volume = {195}, number = {Art. 110734}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0969-8043}, doi = {10.1016/j.apradiso.2023.110734}, year = {2023}, abstract = {We present the production of 58mCo on a small, 13 MeV medical cyclotron utilizing a siphon style liquid target system. Different concentrated iron(III)-nitrate solutions of natural isotopic distribution were irradiated at varying initial pressures and subsequently separated by solid phase extraction chromatography. The radio cobalt (58m/gCo and 56Co) was successfully produced with saturation activities of (0.35 ± 0.03) MBq μA-1 for 58mCo with a separation recovery of (75 ± 2) \% of cobalt after one separation step utilizing LN-resin.}, language = {en} } @article{HafidiElHatkaSchmitzetal.2024, author = {Hafidi, Youssef and El Hatka, Hicham and Schmitz, Dominik and Krauss, Manuel and Pettrak, J{\"u}rgen and Biel, Markus and Ittobane, Najim}, title = {Sustainable soil additives for water and micronutrient supply: swelling and chelating properties of polyaspartic acid hydrogels utilizing newly developed crosslinkers}, series = {Gels}, volume = {10}, journal = {Gels}, number = {3}, publisher = {MDPI}, address = {Basel}, issn = {2310-2861}, doi = {10.3390/gels10030170}, pages = {Artikel 170}, year = {2024}, abstract = {Drought and water shortage are serious problems in many arid and semi-arid regions. This problem is getting worse and even continues in temperate climatic regions due to climate change. To address this problem, the use of biodegradable hydrogels is increasingly important for the application as water-retaining additives in soil. Furthermore, efficient (micro-)nutrient supply can be provided by the use of tailored hydrogels. Biodegradable polyaspartic acid (PASP) hydrogels with different available (1,6-hexamethylene diamine (HMD) and L-lysine (LYS)) and newly developed crosslinkers based on diesters of glycine (GLY) and (di-)ethylene glycol (DEG and EG, respectively) were synthesized and characterized using Fourier transform infrared (FTIR) spectroscopy and scanning electron microscopy (SEM) and regarding their swelling properties (kinetic, absorbency under load (AUL)) as well as biodegradability of PASP hydrogel. Copper (II) and zinc (II), respectively, were loaded as micronutrients in two different approaches: in situ with crosslinking and subsequent loading of prepared hydrogels. The results showed successful syntheses of di-glycine-ester-based crosslinkers. Hydrogels with good water-absorbing properties were formed. Moreover, the developed crosslinking agents in combination with the specific reaction conditions resulted in higher water absorbency with increased crosslinker content used in synthesis (10\% vs. 20\%). The prepared hydrogels are candidates for water-storing soil additives due to the biodegradability of PASP, which is shown in an exemple. The incorporation of Cu(II) and Zn(II) ions can provide these micronutrients for plant growth.}, language = {en} } @article{BaringhausGaigall2019, author = {Baringhaus, Ludwig and Gaigall, Daniel}, title = {On an asymptotic relative efficiency concept based on expected volumes of confidence regions}, series = {Statistics - A Journal of Theoretical and Applied Statistic}, volume = {53}, journal = {Statistics - A Journal of Theoretical and Applied Statistic}, number = {6}, publisher = {Taylor \& Francis}, address = {London}, issn = {1029-4910}, doi = {10.1080/02331888.2019.1683560}, pages = {1396 -- 1436}, year = {2019}, abstract = {The paper deals with an asymptotic relative efficiency concept for confidence regions of multidimensional parameters that is based on the expected volumes of the confidence regions. Under standard conditions the asymptotic relative efficiencies of confidence regions are seen to be certain powers of the ratio of the limits of the expected volumes. These limits are explicitly derived for confidence regions associated with certain plugin estimators, likelihood ratio tests and Wald tests. Under regularity conditions, the asymptotic relative efficiency of each of these procedures with respect to each one of its competitors is equal to 1. The results are applied to multivariate normal distributions and multinomial distributions in a fairly general setting.}, language = {en} } @article{BaringhausGaigall2015, author = {Baringhaus, Ludwig and Gaigall, Daniel}, title = {On an independence test approach to the goodness-of-fit problem}, series = {Journal of Multivariate Analysis}, volume = {2015}, journal = {Journal of Multivariate Analysis}, number = {140}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0047-259X}, doi = {10.1016/j.jmva.2015.05.013}, pages = {193 -- 208}, year = {2015}, abstract = {Let X₁,…,Xₙ be independent and identically distributed random variables with distribution F. Assuming that there are measurable functions f:R²→R and g:R²→R characterizing a family F of distributions on the Borel sets of R in the way that the random variables f(X₁,X₂),g(X₁,X₂) are independent, if and only if F∈F, we propose to treat the testing problem H:F∈F,K:F∉F by applying a consistent nonparametric independence test to the bivariate sample variables (f(Xᵢ,Xⱼ),g(Xᵢ,Xⱼ)),1⩽i,j⩽n,i≠j. A parametric bootstrap procedure needed to get critical values is shown to work. The consistency of the test is discussed. The power performance of the procedure is compared with that of the classical tests of Kolmogorov-Smirnov and Cram{\´e}r-von Mises in the special cases where F is the family of gamma distributions or the family of inverse Gaussian distributions.}, language = {en} } @article{KlingeOttoMuehl2015, author = {Klinge, Uwe and Otto, Jens and M{\"u}hl, Thomas}, title = {High Structural Stability of Textile Implants Prevents Pore Collapse and Preserves Effective Porosity at Strain}, series = {BioMed Research International}, volume = {2015}, journal = {BioMed Research International}, issn = {2314-6133 (Print)}, doi = {10.1155/2015/953209}, pages = {7 pages}, year = {2015}, language = {en} } @article{FrauenrathNiendorfKob2008, author = {Frauenrath, Tobias and Niendorf, Thoralf and Kob, Malte}, title = {Acoustic method for synchronization of Magnetic Resonance Imaging (MRI)}, series = {Acta Acustica}, volume = {94}, journal = {Acta Acustica}, number = {1}, publisher = {Hirzel}, address = {Stuttgart}, issn = {1861-9959}, doi = {10.3813/AAA.918017}, pages = {148 -- 155}, year = {2008}, abstract = {Magnetic Resonance Imaging (MRI) of moving organs requires synchronization with physiological motion or flow, which dictate the viable window for data acquisition. To meet this challenge, this study proposes an acoustic gating device (ACG) that employs acquisition and processing of acoustic signals for synchronization while providing MRI compatibility, immunity to interferences with electro-magnetic and acoustic fields and suitability for MRI at high magnetic field strengths. The applicability and robustness of the acoustic gating approach is examined in a pilot study, where it substitutes conventional ECG-gating for cardiovascular MR. The merits and limitations of the ACG approach are discussed. Implications for MR imaging in the presence of physiological motion are considered including synchronization with other structure- or motion borne sounds.}, language = {en} } @article{BiewendtBlaschkeBoehnert2020, author = {Biewendt, Marcel and Blaschke, Florian and B{\"o}hnert, Arno}, title = {The rebound effect - a systematic review of the current state of affairs}, series = {European Journal of Economics and Business Studies}, volume = {6}, journal = {European Journal of Economics and Business Studies}, number = {1}, publisher = {Revistia}, address = {London}, issn = {2601-8659}, doi = {10.26417/134nvy47z}, pages = {106 -- 120}, year = {2020}, abstract = {This publication is intended to present the current state of research on the rebound effect. First, a systematic literature review is carried out to outline (current) scientific models and theories. Research Question 1 follows with a mathematical introduction of the rebound effect, which shows the interdependence of consumer behaviour, technological progress, and interwoven effects for both. Thereupon, the research field is analysed for gaps and limitations by a systematic literature review. To ensure quantitative and qualitative results, a review protocol is used that integrates two different stages and covers all relevant publications released between 2000 and 2019. Accordingly, 392 publications were identified that deal with the rebound effect. These papers were reviewed to obtain relevant information on the two research questions. The literature review shows that research on the rebound effect is not yet comprehensive and focuses mainly on the effect itself rather than solutions to avoid it. Research Question 2 finds that the main gap, and thus the limitations, is that not much research has been published on the actual avoidance of the rebound effect yet. This is a major limitation for practical application by decision-makers and politicians. Therefore, a theoretical analysis was carried out to identify potential theories and ideas to avoid the rebound effect. The most obvious idea to solve this problem is the theory of a Steady-State Economy (SSE), which has been described and reviewed.}, language = {en} } @article{ClaerFerreinSchiffer2019, author = {Claer, Mario and Ferrein, Alexander and Schiffer, Stefan}, title = {Calibration of a Rotating or Revolving Platform with a LiDAR Sensor}, series = {Applied Sciences}, volume = {Volume 9}, journal = {Applied Sciences}, number = {issue 11, 2238}, publisher = {MDPI}, address = {Basel}, issn = {2076-3417}, doi = {10.3390/app9112238}, pages = {18 Seiten}, year = {2019}, language = {en} } @article{KahmannRauschPluemeretal.2022, author = {Kahmann, Stephanie L. and Rausch, Valentin and Pl{\"u}mer, Jonathan and M{\"u}ller, Lars P. and Pieper, Martin and Wegmann, Kilian}, title = {The automized fracture edge detection and generation of three-dimensional fracture probability heat maps}, series = {Medical Engineering \& Physics}, volume = {2022}, journal = {Medical Engineering \& Physics}, number = {110}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1350-4533}, pages = {7 Seiten}, year = {2022}, abstract = {With proven impact of statistical fracture analysis on fracture classifications, it is desirable to minimize the manual work and to maximize repeatability of this approach. We address this with an algorithm that reduces the manual effort to segmentation, fragment identification and reduction. The fracture edge detection and heat map generation are performed automatically. With the same input, the algorithm always delivers the same output. The tool transforms one intact template consecutively onto each fractured specimen by linear least square optimization, detects the fragment edges in the template and then superimposes them to generate a fracture probability heat map. We hypothesized that the algorithm runs faster than the manual evaluation and with low (< 5 mm) deviation. We tested the hypothesis in 10 fractured proximal humeri and found that it performs with good accuracy (2.5 mm ± 2.4 mm averaged Euclidean distance) and speed (23 times faster). When applied to a distal humerus, a tibia plateau, and a scaphoid fracture, the run times were low (1-2 min), and the detected edges correct by visual judgement. In the geometrically complex acetabulum, at a run time of 78 min some outliers were considered acceptable. An automatically generated fracture probability heat map based on 50 proximal humerus fractures matches the areas of high risk of fracture reported in medical literature. Such automation of the fracture analysis method is advantageous and could be extended to reduce the manual effort even further.}, language = {en} } @article{BiewendtBlaschkeBoehnert2020, author = {Biewendt, Marcel and Blaschke, Florian and B{\"o}hnert, Arno}, title = {An evaluation of corporate sustainability in context of the Jevons paradox}, series = {SocioEconomic Challenges}, volume = {4}, journal = {SocioEconomic Challenges}, number = {3}, publisher = {ARMG Publishing}, address = {Sumy}, issn = {2520-6214}, doi = {10.21272/sec.4(3).46-65.2020}, pages = {46 -- 65}, year = {2020}, abstract = {The successful implementation and continuous development of sustainable corporate-level solutions is a challenge. These are endeavours in which social, environmental, and financial aspects must be weighed against each other. They can prove difficult to handle and, in some cases, almost unrealistic. Concepts such as green controlling, IT, and manufacturing look promising and are constantly evolving. This paper aims to achieve a better understanding of the field of corporate sustainability (CS). It will evaluate the hypothesis by which Corporate Sustainability thrives, via being efficient, increasing the performance, and raising the value of the input of the enterprises to the resources used. In fact, Corporate Sustainability on the surface could seem to contradict the idea, which supports the understanding that it encourages the reduction of the heavy reliance on the use of natural resources, the overall environmental impact, and above all, their protection. To understand how the contradictory notion of CS came about, in this part of the paper, the emphasis is placed on providing useful insight to this regard. The first part of this paper summarizes various definitions, organizational theories, and measures used for CS and its derivatives like green controlling, IT, and manufacturing. Second, a case study is given that combines the aforementioned sustainability models. In addition to evaluating the hypothesis, the overarching objective of this paper is to demonstrate the use of green controlling, IT, and manufacturing in the corporate sector. Furthermore, this paper outlines the current challenges and possible directions for CS in the future.}, language = {en} } @article{EngelmannSimsekShalabyetal.2024, author = {Engelmann, Ulrich M. and Simsek, Beril and Shalaby, Ahmed and Krause, Hans-Joachim}, title = {Key contributors to signal generation in frequency mixing magnetic detection (FMMD): an in silico study}, series = {Sensors}, volume = {24}, journal = {Sensors}, number = {6}, publisher = {MDPI}, address = {Basel}, issn = {1424-8220}, doi = {10.3390/s24061945}, pages = {Artikel 1945}, year = {2024}, abstract = {Frequency mixing magnetic detection (FMMD) is a sensitive and selective technique to detect magnetic nanoparticles (MNPs) serving as probes for binding biological targets. Its principle relies on the nonlinear magnetic relaxation dynamics of a particle ensemble interacting with a dual frequency external magnetic field. In order to increase its sensitivity, lower its limit of detection and overall improve its applicability in biosensing, matching combinations of external field parameters and internal particle properties are being sought to advance FMMD. In this study, we systematically probe the aforementioned interaction with coupled N{\´e}el-Brownian dynamic relaxation simulations to examine how key MNP properties as well as applied field parameters affect the frequency mixing signal generation. It is found that the core size of MNPs dominates their nonlinear magnetic response, with the strongest contributions from the largest particles. The drive field amplitude dominates the shape of the field-dependent response, whereas effective anisotropy and hydrodynamic size of the particles only weakly influence the signal generation in FMMD. For tailoring the MNP properties and parameters of the setup towards optimal FMMD signal generation, our findings suggest choosing large particles of core sizes dc > 25 nm nm with narrow size distributions (σ < 0.1) to minimize the required drive field amplitude. This allows potential improvements of FMMD as a stand-alone application, as well as advances in magnetic particle imaging, hyperthermia and magnetic immunoassays.}, language = {en} } @article{HorbachStaat2018, author = {Horbach, Andreas and Staat, Manfred}, title = {Optical strain measurement for the modeling of surgical meshes and their porosity}, series = {Current Directions in Biomedical Engineering}, volume = {Band 4}, journal = {Current Directions in Biomedical Engineering}, number = {1}, publisher = {De Gruyter}, address = {Berlin}, issn = {2364-5504}, doi = {10.1515/cdbme-2018-0045}, pages = {181 -- 184}, year = {2018}, abstract = {The porosity of surgical meshes makes them flexible for large elastic deformation and establishes the healing conditions of good tissue in growth. The biomechanic modeling of orthotropic and compressible materials requires new materials models and simulstaneoaus fit of deformation in the load direction as well as trannsversely to to load. This nonlinear modeling can be achieved by an optical deformation measurement. At the same time the full field deformation measurement allows the dermination of the change of porosity with deformation. Also the socalled effective porosity, which has been defined to asses the tisssue interatcion with the mesh implants, can be determined from the global deformation of the surgical meshes.}, language = {en} } @article{BaringhausGaigall2017, author = {Baringhaus, Ludwig and Gaigall, Daniel}, title = {Hotelling's T² tests in paired and independent survey samples: An efficiency comparison}, series = {Journal of Multivariate Analysis}, volume = {2017}, journal = {Journal of Multivariate Analysis}, number = {154}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0047-259X}, doi = {10.1016/j.jmva.2016.11.004}, pages = {177 -- 198}, year = {2017}, abstract = {Hotelling's T² tests in paired and independent survey samples are compared using the traditional asymptotic efficiency concepts of Hodges-Lehmann, Bahadur and Pitman, as well as through criteria based on the volumes of corresponding confidence regions. Conditions characterizing the superiority of a procedure are given in terms of population canonical correlation type coefficients. Statistical tests for checking these conditions are developed. Test statistics based on the eigenvalues of a symmetrized sample cross-covariance matrix are suggested, as well as test statistics based on sample canonical correlation type coefficients.}, language = {en} } @article{WangAnikFrohberg1987, author = {Wang, Mao and Anik, Sabri and Frohberg, Martin G.}, title = {Thermodynamics of oxygen in the lead-antimony system at 1173 K}, series = {Erzmetall : Rohstoffgewinnung, Verarbeitung, Recycling, Umwelttechnik}, volume = {40}, journal = {Erzmetall : Rohstoffgewinnung, Verarbeitung, Recycling, Umwelttechnik}, number = {6}, issn = {0044-2658}, pages = {316 -- 319}, year = {1987}, language = {en} } @article{HerrmannKearney2002, author = {Herrmann, Ulf and Kearney, David W.}, title = {Survey of Thermal Energy Storage for Parabolic Trough Power Plants}, series = {Journal of Solar Energy Engineering}, volume = {124}, journal = {Journal of Solar Energy Engineering}, number = {2}, issn = {1528-8986 (Online)}, doi = {10.1115/1.1467601}, pages = {145 -- 152}, year = {2002}, language = {en} } @article{LevesqueSiegwolfEilmannetal.2014, author = {L{\´e}vesque, Mathieu and Siegwolf, Rolf and Eilmann, Britta and Saurer, Matthias and Rigling, Andreas}, title = {Increased water-use efficiency does not lead to enhanced tree growth under xeric and mesic conditions}, series = {New Phytologist}, volume = {203}, journal = {New Phytologist}, number = {1}, publisher = {Wiley-Blackwell}, address = {Oxford}, issn = {1469-8137 (Online)}, doi = {10.1111/nph.12772}, pages = {94 -- 109}, year = {2014}, language = {en} } @article{KearneyKellyHerrmannetal.2002, author = {Kearney, David W. and Kelly, Bruce and Herrmann, Ulf and Cable, R. and Pacheco, J. and Mahoney, R. and Price, Henry and Blake, D. and Nava, P. and Potrovitza, N.}, title = {Engineering Aspects of a Molten Salt Heat Transfer Fluid in a Trough Solar Field}, series = {Energy : the international journal}, volume = {29}, journal = {Energy : the international journal}, number = {5-6 (Special Issue SolarPaces)}, issn = {0360-5442}, doi = {10.1016/S0360-5442(03)00191-9}, pages = {861 -- 870}, year = {2002}, language = {en} } @article{FrohbergAnik1985, author = {Frohberg, Martin G. and Anik, Sabri}, title = {Thermodynamic relations between component activities and gas solubilities in binary metallic systems}, series = {Berichte der Bunsengesellschaft f{\"u}r physikalische Chemie}, volume = {89}, journal = {Berichte der Bunsengesellschaft f{\"u}r physikalische Chemie}, number = {2}, issn = {0940-483X}, pages = {130 -- 134}, year = {1985}, language = {en} } @article{HafnerDemetzWeickertetal.2014, author = {Hafner, David and Demetz, Oliver and Weickert, Joachim and Reißel, Martin}, title = {Mathematical Foundations and Generalisations of the Census Transform for Robust Optic Flow Computation}, series = {Journal of Mathematical Imaging and Vision}, journal = {Journal of Mathematical Imaging and Vision}, publisher = {Springer}, address = {New York}, issn = {1573-7683 (Online)}, doi = {10.1007/s10851-014-0529-9}, year = {2014}, language = {en} } @article{Helmig2015, author = {Helmig, Ilka}, title = {A few (hi)stories about french illustration}, series = {Slanted}, journal = {Slanted}, number = {25 (Paris)}, publisher = {Slanted Publishers}, address = {Karlsruhe}, issn = {1867-6510}, pages = {210 -- 217}, year = {2015}, language = {en} } @article{DammSauerbornFendetal.2017, author = {Damm, Marc Andr{\´e} and Sauerborn, Markus and Fend, Thomas and Herrmann, Ulf}, title = {Optimisation of a urea selective catalytic reduction system with a coated ceramic mixing element}, series = {Journal of ceramic science and technology}, volume = {8}, journal = {Journal of ceramic science and technology}, number = {1}, publisher = {G{\"o}ller}, address = {Baden-Baden}, isbn = {2190-9385 (Print)}, issn = {2190-9385 (Online)}, doi = {10.4416/JCST2016-00056}, pages = {19 -- 24}, year = {2017}, language = {en} } @article{AnikFrohberg1984, author = {Anik, Sabri and Frohberg, Martin G.}, title = {Investigations of the thermodynamics of oxygen and the determination of the miscibility gap in the system copper-oxygen-lead at 12000C}, series = {Zeitschrift f{\"u}r Metallkunde}, volume = {75}, journal = {Zeitschrift f{\"u}r Metallkunde}, number = {8}, issn = {0044-3093}, pages = {586 -- 589}, year = {1984}, language = {en} } @article{AbdelLatifPeekenBenner1985, author = {Abdel-Latif, Lotfie Ahmed and Peeken, Heinz and Benner, Joachim}, title = {Thermohydrodynamic analysis of thrust-bearing with circular pads running on bubbly oil (BTHD-theory)}, series = {Journal of tribology}, volume = {107}, journal = {Journal of tribology}, number = {4}, isbn = {0742-4787}, issn = {1528-8897}, pages = {527 -- 537}, year = {1985}, language = {en} } @article{AnikKapoorFrohberg1983, author = {Anik, Sabri and Kapoor, Madan Lal and Frohberg, Martin G.}, title = {Thermodynamic behaviour of oxygen in molten substitutional alloy solvents}, series = {Zeitschrift f{\"u}r Metallkunde}, volume = {74}, journal = {Zeitschrift f{\"u}r Metallkunde}, number = {1}, issn = {0044-3093}, pages = {53 -- 58}, year = {1983}, language = {en} } @article{OehlenschlaegerVolkmarStiefelmaieretal.2024, author = {Oehlenschl{\"a}ger, Katharina and Volkmar, Marianne and Stiefelmaier, Judith and Langsdorf, Alexander and Holtmann, Dirk and Tippk{\"o}tter, Nils and Ulber, Roland}, title = {New insights into the influence of pre-culture on robust solvent production of C. acetobutylicum}, series = {Applied Microbiology and Biotechnology}, volume = {108}, journal = {Applied Microbiology and Biotechnology}, publisher = {Springer}, address = {Berlin, Heidelberg}, issn = {1432-0614}, doi = {10.1007/s00253-023-12981-8}, pages = {10 Seiten}, year = {2024}, abstract = {Clostridia are known for their solvent production, especially the production of butanol. Concerning the projected depletion of fossil fuels, this is of great interest. The cultivation of clostridia is known to be challenging, and it is difficult to achieve reproducible results and robust processes. However, existing publications usually concentrate on the cultivation conditions of the main culture. In this paper, the influence of cryo-conservation and pre-culture on growth and solvent production in the resulting main cultivation are examined. A protocol was developed that leads to reproducible cultivations of Clostridium acetobutylicum. Detailed investigation of the cell conservation in cryo-cultures ensured reliable cell growth in the pre-culture. Moreover, a reason for the acid crash in the main culture was found, based on the cultivation conditions of the pre-culture. The critical parameter to avoid the acid crash and accomplish the shift to the solventogenesis of clostridia is the metabolic phase in which the cells of the pre-culture were at the time of inoculation of the main culture; this depends on the cultivation time of the pre-culture. Using cells from the exponential growth phase to inoculate the main culture leads to an acid crash. To achieve the solventogenic phase with butanol production, the inoculum should consist of older cells which are in the stationary growth phase. Considering these parameters, which affect the entire cultivation process, reproducible results and reliable solvent production are ensured.}, language = {en} } @article{KruegerGroetzingerBerndt1987, author = {Kr{\"u}ger, G{\"o}tz and Gr{\"o}tzinger, Joachim and Berndt, Heinz}, title = {Enantiomeric resolution of amino acid derivatives on chiral stationary phases by high-performance liquid chromatography}, series = {Journal of Chromatography A}, volume = {1987}, journal = {Journal of Chromatography A}, number = {397}, issn = {0021-9673}, doi = {10.1016/S0021-9673(01)85005-6}, pages = {223 -- 232}, year = {1987}, language = {en} } @article{FontiEilmannGarciaGonzalezetal.2009, author = {Fonti, Patrick and Eilmann, Britta and Garc{\´i}a-Gonz{\´a}lez, Ignacio and von Arx, Georg}, title = {Expeditious building of ring-porous earlywood vessel chronologies without loosing signal information}, series = {Trees : structure and function}, volume = {23}, journal = {Trees : structure and function}, number = {3}, publisher = {Springer}, address = {Berlin}, issn = {0931-1890 (Print)}, doi = {10.1007/s00468-008-0310-z}, pages = {665 -- 671}, year = {2009}, language = {en} } @article{HerrmannLippke1999, author = {Herrmann, Ulf and Lippke, F.}, title = {The influence of transients on the design of DSG solar fields}, series = {Journal de Physique IV : proceedings}, volume = {9}, journal = {Journal de Physique IV : proceedings}, number = {PR3}, isbn = {2-86883-402-7}, issn = {1764-7177 (Online)}, doi = {10.1051/jp4:1999377}, pages = {489 -- 494}, year = {1999}, language = {en} } @article{WangAnikFrohberg1988, author = {Wang, Mao and Anik, Sabri and Frohberg, Martin G.}, title = {Experiments on the electrochemical determination of the sulphur activities in the system copper-silver at 1200°C}, series = {Zeitschrift f{\"u}r Metallkunde}, volume = {79}, journal = {Zeitschrift f{\"u}r Metallkunde}, number = {5}, issn = {0044-3093}, pages = {336 -- 339}, year = {1988}, language = {en} } @article{EilmannZweifelBuchmannetal.2011, author = {Eilmann, Britta and Zweifel, Roman and Buchmann, Nina and Graf Pannatier, Elisabeth and Rigling, Andreas}, title = {Drought alters timing, quantity, and quality of wood formation in Scots pine}, series = {Journal of Experimental Botany}, volume = {62}, journal = {Journal of Experimental Botany}, number = {8}, publisher = {Oxford University Press}, address = {Oxford}, issn = {1460-2431 (Online)}, doi = {10.1093/jxb/erq443}, pages = {2763 -- 2771}, year = {2011}, language = {en} } @article{AnikFrohbergKapoor1983, author = {Anik, Sabri and Frohberg, Martin G. and Kapoor, Madan Lal}, title = {Prediction of thermodynamic properties of oxygen in binary metallic solvents}, series = {Zeitschrift f{\"u}r Metallkunde}, volume = {74}, journal = {Zeitschrift f{\"u}r Metallkunde}, number = {6}, issn = {0044-3093}, pages = {372 -- 375}, year = {1983}, language = {en} }