@article{MalanHamerKaeneletal.2020, author = {Malan, Leone and Hamer, Mark and K{\"a}nel, Roland von and Kotliar, Konstantin and Wyk, Roelof D. van and Lambert, Gavin W. and Vilser, Walthard and Ziemssen, Tjalf and Schlaich, Markus P. and Smith, Wayne and Magnusson, Martin and Wentzel, Annemarie and Myburgh, Carlien E. and Steyn, Hendrik S. and Malan, Nico T.}, title = {Delayed retinal vein recovery responses indicate both non-adaptation to stress as well as increased risk for stroke: the SABPA study}, series = {Cardiovascular Journal of Africa}, volume = {26}, journal = {Cardiovascular Journal of Africa}, number = {31}, publisher = {Clinics Cardive Publishing}, address = {Durbanville}, issn = {1680-0745}, doi = {10.5830/CVJA-2020-031}, pages = {1 -- 12}, year = {2020}, language = {en} } @article{StreeseKotliarDeiserothetal.2020, author = {Streese, Lukas and Kotliar, Konstantin and Deiseroth, Arne and Infanger, Denis and Gugleta, Konstantin and Schmaderer, Christoph and Hanssen, Henner}, title = {Retinal endothelial function in cardiovascular risk patients: A randomized controlled exercise trial}, series = {Scandinavian Journal of Medicine and Science in Sports}, volume = {30}, journal = {Scandinavian Journal of Medicine and Science in Sports}, number = {2}, publisher = {Wiley}, address = {Oxford}, issn = {1600-0838}, doi = {10.1111/sms.13560}, pages = {272 -- 280}, year = {2020}, abstract = {The aim of this study was to investigate, for the first time, the effects of high-intensity interval training (HIIT) on retinal microvascular endothelial function in cardiovascular (CV) risk patients. In the randomized controlled trial, middle-aged and previously sedentary patients with increased CV risk (aged 58 ± 6 years) with ≥ two CV risk factors were randomized into a 12-week HIIT (n = 33) or control group (CG, n = 36) with standard physical activity recommendations. A blinded examiner measured retinal endothelial function by flicker light-induced maximal arteriolar (ADmax) and venular (VDmax) dilatation as well as the area under the arteriolar (AFarea) and venular (VFarea) flicker curve using a retinal vessel analyzer. Standardized assessments of CV risk factors, cardiorespiratory fitness, and retinal endothelial function were performed before and after HIIT. HIIT reduced body mass index, fat mass, and low-density lipoprotein and increased muscle mass and peak oxygen uptake (VO2peak). Both ADmax (pre: 2.7 ± 2.1\%, post: 3.0 ± 2.2\%, P = .018) and AFarea (pre: 32.6 ± 28.4\%*s, post: 37.7 ± 30.6\%*s, P = .016) increased after HIIT compared with CG (ADmax, pre: 3.2 ± 1.8\%, post: 2.9 ± 1.8\%, P = .254; AFarea, pre: 41.6 ± 28.5\%*s, post: 37.8 ± 27.0\%*s, P = .186). Venular function remained unchanged after HIIT. There was a significant association between ∆-change VO2peak and ∆-changes ADmax and AFarea (P = .026, R² = 0.073; P = .019, R² = 0.081, respectively). 12-weeks of HIIT improved retinal endothelial function in middle-aged patients with increased CV risk independent of the reduction in classical CV risk factors. Exercise has the potential to reverse or at least postpone progression of small vessel disease in older adults with increased CV risk under standard medication. Dynamic retinal vessel analysis seems to be a sensitive tool to detect treatment effects of exercise interventions on retinal microvascular endothelial function in middle-aged individuals with increased CV risk.}, language = {en} } @article{HamouKotliarTanetal.2020, author = {Hamou, Hussam Aldin and Kotliar, Konstantin and Tan, Sonny Kian and Weiß, Christel and Blume, Christian and Clusmann, Hans and Schubert, Gerrit Alexander and Albanna, Walid}, title = {Surgical nuances and placement of subgaleal drains for supratentorial procedures—a prospective analysis of efficacy and outcome in 150 craniotomies}, series = {Acta Neurochirurgica}, volume = {2020}, journal = {Acta Neurochirurgica}, number = {162}, publisher = {Springer Nature}, address = {Cham}, issn = {0942-0940}, doi = {10.1007/s00701-019-04196-6}, pages = {729 -- 736}, year = {2020}, abstract = {Background For supratentorial craniotomy, surgical access, and closure technique, including placement of subgaleal drains, may vary considerably. The influence of surgical nuances on postoperative complications such as cerebrospinal fluid leakage or impaired wound healing overall remains largely unclear. With this study, we are reporting our experiences and the impact of our clinical routines on outcome in a prospectively collected data set. Method We prospectively observed 150 consecutive patients undergoing supratentorial craniotomy and recorded technical variables (type/length of incision, size of craniotomy, technique of dural and skin closure, type of dressing, and placement of subgaleal drains). Outcome variables (subgaleal hematoma/CSF collection, periorbital edema, impairment of wound healing, infection, and need for operative revision) were recorded at time of discharge and at late follow-up. Results Early subgaleal fluid collection was observed in 36.7\% (2.8\% at the late follow-up), and impaired wound healing was recorded in 3.3\% of all cases, with an overall need for operative revision of 6.7\%. Neither usage of dural sealants, lack of watertight dural closure, and presence of subgaleal drains, nor type of skin closure or dressing influenced outcome. Curved incisions, larger craniotomy, and tumor size, however, were associated with an increase in early CSF or hematoma collection (p < 0.0001, p = 0.001, p < 0.01 resp.), and larger craniotomy size was associated with longer persistence of subgaleal fluid collections (p < 0.05). Conclusions Based on our setting, individual surgical nuances such as the type of dural closure and the use of subgaleal drains resulted in a comparable complication rate and outcome. Subgaleal fluid collections were frequently observed after supratentorial procedures, irrespective of the closing technique employed, and resolve spontaneously in the majority of cases without significant sequelae. Our results are limited due to the observational nature in our single-center study and need to be validated by supportive prospective randomized design.}, language = {en} } @article{RamoshabaHuismanLammertynetal.2020, author = {Ramoshaba, Nthai E. and Huisman, Hugo W. and Lammertyn, Leandi and Kotliar, Konstantin and Schutte, Aletta E. and Smith, Wayne}, title = {Retinal microvasculature and masked hypertension in young adults: the African-PREDICT study}, series = {Hypertension Research}, journal = {Hypertension Research}, number = {43}, publisher = {Springer Nature}, address = {Osaka}, issn = {1348-4214}, doi = {10.1038/s41440-020-0487-0}, pages = {1231 -- 1238}, year = {2020}, abstract = {Masked hypertension is known to induce microvascular complications. However, it is unclear whether early microvascular changes are already occurring in young, otherwise healthy adults. We therefore investigated whether retinal microvascular calibers and acute responses to a flicker stimulus are related to masked hypertension. We used the baseline data of 889 participants aged 20-30 years who were taking part in the African Prospective study on the Early Detection and Identification of Cardiovascular Disease and Hypertension. Clinic and 24-h ambulatory blood pressure were measured. The central retinal artery equivalent (CRAE) and central retinal vein equivalent were calculated from fundus images, and retinal vessel dilation was determined in response to flicker light-induced provocation. A smaller CRAE was observed in those with masked hypertension vs. those with normotension (157.1 vs. 161.2 measuring units, P < 0.001). In forward multivariable-adjusted regression analysis, only CRAE was negatively related to masked hypertension [adjusted R² = 0.267, β = -0.097 (95\% CI = -0.165; -0.029), P = 0.005], but other retinal microvascular parameters were not associated with masked hypertension. In multivariable logistic regression analyses, masked hypertension [OR = 2.333, (95\% CI = 1.316; 4.241), P = 0.004] was associated with a narrower CRAE. In young healthy adults, masked hypertension was associated with retinal arteriolar narrowing, thereby reflecting early microvascular alterations known to predict cardiovascular outcomes in later life.}, language = {en} } @article{SmithKotliarLammertynetal.2020, author = {Smith, Wayne and Kotliar, Konstantin and Lammertyn, Leandi and Ramoshaba, Nthai E. and Vilser, Walthard and Huisman, Hugo W. and Schutte, Aletta E.}, title = {Retinal vessel caliber and caliber responses in true normotensive black and white adults: The African-PREDICT study}, series = {Microvascular Research}, volume = {128}, journal = {Microvascular Research}, number = {Article 103937}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0026-2862}, doi = {10.1016/j.mvr.2019.103937}, year = {2020}, abstract = {Purpose Globally, a detrimental shift in cardiovascular disease risk factors and a higher mortality level are reported in some black populations. The retinal microvasculature provides early insight into the pathogenesis of systemic vascular diseases, but it is unclear whether retinal vessel calibers and acute retinal vessel functional responses differ between young healthy black and white adults. Methods We included 112 black and 143 white healthy normotensive adults (20-30 years). Retinal vessel calibers (central retinal artery and vein equivalent (CRAE and CRVE)) were calculated from retinal images and vessel caliber responses to flicker light induced provocation (FLIP) were determined. Additionally, ambulatory blood pressure (BP), anthropometry and blood samples were collected. Results The groups displayed similar 24 h BP profiles and anthropometry (all p > .24). Black participants demonstrated a smaller CRAE (158 ± 11 vs. 164 ± 11 MU, p < .001) compared to the white group, whereas CRVE was similar (p = .57). In response to FLIP, artery maximal dilation was greater in the black vs. white group (5.6 ± 2.1 vs. 3.3 ± 1.8\%; p < .001). Conclusions Already at a young age, healthy black adults showed narrower retinal arteries relative to the white population. Follow-up studies are underway to show if this will be related to increased risk for hypertension development. The reason for the larger vessel dilation responses to FLIP in the black population is unclear and warrants further investigation.}, language = {en} } @article{NeumaierKotliarHaerenetal.2021, author = {Neumaier, Felix and Kotliar, Konstantin and Haeren, Roel Hubert Louis and Temel, Yasin and L{\"u}ke, Jan Niklas and Seyam, Osama and Lindauer, Ute and Clusmann, Hans and Hescheler, J{\"u}rgen and Schubert, Gerrit Alexander and Schneider, Toni and Albanna, Walid}, title = {Retinal Vessel Responses to Flicker Stimulation Are Impaired in Ca v 2.3-Deficient Mice—An in- vivo Evaluation Using Retinal Vessel Analysis (RVA)}, series = {Frontiers in Neurology}, volume = {12}, journal = {Frontiers in Neurology}, publisher = {Frontiers}, doi = {10.3389/fneur.2021.659890}, pages = {1 -- 11}, year = {2021}, language = {en} } @article{Staat2021, author = {Staat, Manfred}, title = {An extension strain type Mohr-Coulomb criterion}, series = {Rock mechanics and rock engineering}, volume = {54}, journal = {Rock mechanics and rock engineering}, number = {12}, publisher = {Springer Nature}, address = {Cham}, issn = {1434-453X}, doi = {10.1007/s00603-021-02608-7}, pages = {6207 -- 6233}, year = {2021}, abstract = {Extension fractures are typical for the deformation under low or no confining pressure. They can be explained by a phenomenological extension strain failure criterion. In the past, a simple empirical criterion for fracture initiation in brittle rock has been developed. In this article, it is shown that the simple extension strain criterion makes unrealistic strength predictions in biaxial compression and tension. To overcome this major limitation, a new extension strain criterion is proposed by adding a weighted principal shear component to the simple criterion. The shear weight is chosen, such that the enriched extension strain criterion represents the same failure surface as the Mohr-Coulomb (MC) criterion. Thus, the MC criterion has been derived as an extension strain criterion predicting extension failure modes, which are unexpected in the classical understanding of the failure of cohesive-frictional materials. In progressive damage of rock, the most likely fracture direction is orthogonal to the maximum extension strain leading to dilatancy. The enriched extension strain criterion is proposed as a threshold surface for crack initiation CI and crack damage CD and as a failure surface at peak stress CP. Different from compressive loading, tensile loading requires only a limited number of critical cracks to cause failure. Therefore, for tensile stresses, the failure criteria must be modified somehow, possibly by a cut-off corresponding to the CI stress. Examples show that the enriched extension strain criterion predicts much lower volumes of damaged rock mass compared to the simple extension strain criterion.}, language = {en} } @article{UysalCreutzFiratetal.2022, author = {Uysal, Karya and Creutz, Till and Firat, Ipek Seda and Artmann, Gerhard and Teusch, Nicole and Temiz Artmann, Ayseg{\"u}l}, title = {Bio-functionalized ultra-thin, large-area and waterproof silicone membranes for biomechanical cellular loading and compliance experiments}, series = {Polymers}, volume = {14}, journal = {Polymers}, number = {11}, publisher = {MDPI}, address = {Basel}, issn = {2073-4360}, pages = {2213}, year = {2022}, abstract = {Biocompatibility, flexibility and durability make polydimethylsiloxane (PDMS) membranes top candidates in biomedical applications. CellDrum technology uses large area, <10 µm thin membranes as mechanical stress sensors of thin cell layers. For this to be successful, the properties (thickness, temperature, dust, wrinkles, etc.) must be precisely controlled. The following parameters of membrane fabrication by means of the Floating-on-Water (FoW) method were investigated: (1) PDMS volume, (2) ambient temperature, (3) membrane deflection and (4) membrane mechanical compliance. Significant differences were found between all PDMS volumes and thicknesses tested (p < 0.01). They also differed from the calculated values. At room temperatures between 22 and 26 °C, significant differences in average thickness values were found, as well as a continuous decrease in thicknesses within a 4 °C temperature elevation. No correlation was found between the membrane thickness groups (between 3-4 µm) in terms of deflection and compliance. We successfully present a fabrication method for thin bio-functionalized membranes in conjunction with a four-step quality management system. The results highlight the importance of tight regulation of production parameters through quality control. The use of membranes described here could also become the basis for material testing on thin, viscous layers such as polymers, dyes and adhesives, which goes far beyond biological applications.}, language = {en} } @article{UysalFiratCreutzetal.2022, author = {Uysal, Karya and Firat, Ipek Serat and Creutz, Till and Aydin, Inci Cansu and Artmann, Gerhard and Teusch, Nicole and Temiz Artmann, Ayseg{\"u}l}, title = {A novel in vitro wound healing assay using free-standing, ultra-thin PDMS membranes}, series = {membranes}, volume = {2023}, journal = {membranes}, number = {13(1)}, publisher = {MDPI}, address = {Basel}, doi = {10.3390/membranes13010022}, pages = {Artikel 22}, year = {2022}, abstract = {Advances in polymer science have significantly increased polymer applications in life sciences. We report the use of free-standing, ultra-thin polydimethylsiloxane (PDMS) membranes, called CellDrum, as cell culture substrates for an in vitro wound model. Dermal fibroblast monolayers from 28- and 88-year-old donors were cultured on CellDrums. By using stainless steel balls, circular cell-free areas were created in the cell layer (wounding). Sinusoidal strain of 1 Hz, 5\% strain, was applied to membranes for 30 min in 4 sessions. The gap circumference and closure rate of un-stretched samples (controls) and stretched samples were monitored over 4 days to investigate the effects of donor age and mechanical strain on wound closure. A significant decrease in gap circumference and an increase in gap closure rate were observed in trained samples from younger donors and control samples from older donors. In contrast, a significant decrease in gap closure rate and an increase in wound circumference were observed in the trained samples from older donors. Through these results, we propose the model of a cell monolayer on stretchable CellDrums as a practical tool for wound healing research. The combination of biomechanical cell loading in conjunction with analyses such as gene/protein expression seems promising beyond the scope published here.}, language = {en} } @article{TemizArtmannKurulgandemirciFıratetal.2021, author = {Temiz Artmann, Ayseg{\"u}l and Kurulgan demirci, Eylem and F{\i}rat, Ipek Seda and Oflaz, Hakan and Artmann, Gerhard}, title = {Recombinant activated protein C (rhAPC) affects lipopolysaccharide-induced mechanical compliance changes and beat frequency of mESC-derived cardiomyocyte monolayers}, series = {SHOCK}, journal = {SHOCK}, publisher = {Wolters Kluwer}, address = {K{\"o}ln}, issn = {1540-0514}, doi = {10.1097/SHK.0000000000001845}, year = {2021}, language = {en} } @article{SeifarthGrosseGrossmannetal.2017, author = {Seifarth, Volker and Grosse, Joachim O. and Grossmann, Matthias and Janke, Heinz Peter and Arndt, Patrick and Koch, Sabine and Epple, Matthias and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l}, title = {Mechanical induction of bi-directional orientation of primary porcine bladder smooth muscle cells in tubular fibrin-poly(vinylidene fluoride) scaffolds for ureteral and urethral repair using cyclic and focal balloon catheter stimulation}, series = {Journal of Biomaterials Applications}, volume = {32}, journal = {Journal of Biomaterials Applications}, number = {3}, publisher = {Sage}, address = {London}, issn = {1530-8022}, doi = {10.1177/0885328217723178}, pages = {321 -- 330}, year = {2017}, language = {en} } @article{SeifarthGossmannGrosseetal.2015, author = {Seifarth, Volker and Goßmann, Matthias and Grosse, J. O. and Becker, C. and Heschel, I. and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l}, title = {Development of a Bioreactor to Culture Tissue Engineered Ureters Based on the Application of Tubular OPTIMAIX 3D Scaffolds}, series = {Urologia Internationalis}, volume = {2015}, journal = {Urologia Internationalis}, number = {95}, publisher = {Karger}, address = {Basel}, issn = {0042-1138}, doi = {10.1159/000368419}, pages = {106 -- 113}, year = {2015}, language = {en} } @article{LiphardtFernandezGonzaloAlbrachtetal.2023, author = {Liphardt, Anna-Maria and Fernandez-Gonzalo, Rodrigo and Albracht, Kirsten and Rittweger, J{\"o}rn and Vico, Laurence}, title = {Musculoskeletal research in human space flight - unmet needs for the success of crewed deep space exploration}, series = {npj Microgravity}, volume = {9}, journal = {npj Microgravity}, number = {Article number: 9}, publisher = {Springer Nature}, issn = {2373-8065}, doi = {10.1038/s41526-023-00258-3}, pages = {1 -- 9}, year = {2023}, abstract = {Based on the European Space Agency (ESA) Science in Space Environment (SciSpacE) community White Paper "Human Physiology - Musculoskeletal system", this perspective highlights unmet needs and suggests new avenues for future studies in musculoskeletal research to enable crewed exploration missions. The musculoskeletal system is essential for sustaining physical function and energy metabolism, and the maintenance of health during exploration missions, and consequently mission success, will be tightly linked to musculoskeletal function. Data collection from current space missions from pre-, during-, and post-flight periods would provide important information to understand and ultimately offset musculoskeletal alterations during long-term spaceflight. In addition, understanding the kinetics of the different components of the musculoskeletal system in parallel with a detailed description of the molecular mechanisms driving these alterations appears to be the best approach to address potential musculoskeletal problems that future exploratory-mission crew will face. These research efforts should be accompanied by technical advances in molecular and phenotypic monitoring tools to provide in-flight real-time feedback.}, language = {en} } @article{SeifarthSchehlLinderetal.2011, author = {Seifarth, Volker and Schehl, D. and Linder, Peter and Gossmann, Matthias and Digel, Ilya and Artmann, Gerhard and Porst, Dariusz and Preiß, C. and Kayser, Peter and Pack, O. and Temiz Artmann, Ayseg{\"u}l}, title = {Ureplace: development of a bioreactor for in vitro culturing of cell seeded tubular vessels on collagen scaffolds}, year = {2011}, abstract = {The demand of replacements for inoperable organs exceeds the amount of available organ transplants. Therefore, tissue engineering developed as a multidisciplinary field of research for autologous in-vitro organs. Such three dimensional tissue constructs request the application of a bioreactor. The UREPLACE bioreactor is used to grow cells on tubular collagen scaffolds OPTIMAIX Sponge 1 with a maximal length of 7 cm, in order to culture in vitro an adequate ureter replacement. With a rotating unit, (urothelial) cells can be placed homogeneously on the inner scaffold surface. Furthermore, a stimulation is combined with this bioreactor resulting in an orientation of muscle cells. These culturing methods request a precise control of several parameters and actuators. A combination of a LabBox and the suitable software LabVision is used to set and conduct parameters like rotation angles, velocities, pressures and other important cell culture values. The bioreactor was tested waterproof successfully. Furthermore, the temperature controlling was adjusted to 37 °C and the CO2 - concentration regulated to 5 \%. Additionally, the pH step responses of several substances showed a perfect functioning of the designed flow chamber. All used software was tested and remained stable for several days.}, subject = {Tissue Engineering}, language = {en} } @article{DachwaldSeboldtLaemmerzahl2008, author = {Dachwald, Bernd and Seboldt, Wolfgang and L{\"a}mmerzahl, W.}, title = {Solar Sail Propulsion: An Enabling Technology for Fundamental Physics Missions}, series = {Lasers, Clocks and Drag Free Control : Exploration of Relativistic Gravity in Space / by Hansj{\"o}rg Dittus ..., eds. - ( Astrophysics and Space Science Library ; 349)}, journal = {Lasers, Clocks and Drag Free Control : Exploration of Relativistic Gravity in Space / by Hansj{\"o}rg Dittus ..., eds. - ( Astrophysics and Space Science Library ; 349)}, publisher = {Springer}, address = {Berlin [u.a.]}, isbn = {978-3-540-34376-9}, pages = {379 -- 398}, year = {2008}, language = {en} } @article{JanThimoBauerBieleetal.2019, author = {Jan Thimo, Grundmann and Bauer, Waldemar and Biele, Jens and Boden, Ralf and Ceriotti, Matteo and Cordero, Federico and Dachwald, Bernd and Dumont, Etienne and Grimm, Christian D. and Hercik, David}, title = {Capabilities of Gossamer-1 derived small spacecraft solar sails carrying Mascot-derived nanolanders for in-situ surveying of NEAs}, series = {Acta Astronautica}, volume = {156}, journal = {Acta Astronautica}, number = {3}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0094-5765}, doi = {10.1016/j.actaastro.2018.03.019}, pages = {330 -- 362}, year = {2019}, language = {en} } @article{BayerTemizArtmannDigeletal.2020, author = {Bayer, Robin and Temiz Artmann, Ayseg{\"u}l and Digel, Ilya and Falkenstein, Julia and Artmann, Gerhard and Creutz, Till and Hescheler, J{\"u}rgen}, title = {Mechano-pharmacological testing of L-Type Ca²⁺ channel modulators via human vascular celldrum model}, series = {Cellular Physiology and Biochemistry}, volume = {54}, journal = {Cellular Physiology and Biochemistry}, publisher = {Cell Physiol Biochem Press}, address = {D{\"u}sseldorf}, issn = {1421-9778}, doi = {10.33594/000000225}, pages = {371 -- 383}, year = {2020}, abstract = {Background/Aims: This study aimed to establish a precise and well-defined working model, assessing pharmaceutical effects on vascular smooth muscle cell monolayer in-vitro. It describes various analysis techniques to determine the most suitable to measure the biomechanical impact of vasoactive agents by using CellDrum technology. Methods: The so-called CellDrum technology was applied to analyse the biomechanical properties of confluent human aorta muscle cells (haSMC) in monolayer. The cell generated tensions deviations in the range of a few N/m² are evaluated by the CellDrum technology. This study focuses on the dilative and contractive effects of L-type Ca²⁺ channel agonists and antagonists, respectively. We analyzed the effects of Bay K8644, nifedipine and verapamil. Three different measurement modes were developed and applied to determine the most appropriate analysis technique for the study purpose. These three operation modes are called, particular time mode" (PTM), "long term mode" (LTM) and "real-time mode" (RTM). Results: It was possible to quantify the biomechanical response of haSMCs to the addition of vasoactive agents using CellDrum technology. Due to the supplementation of 100nM Bay K8644, the tension increased approximately 10.6\% from initial tension maximum, whereas, the treatment with nifedipine and verapamil caused a significant decrease in cellular tension: 10nM nifedipine decreased the biomechanical stress around 6,5\% and 50nM verapamil by 2,8\%, compared to the initial tension maximum. Additionally, all tested measurement modes provide similar results while focusing on different analysis parameters. Conclusion: The CellDrum technology allows highly sensitive biomechanical stress measurements of cultured haSMC monolayers. The mechanical stress responses evoked by the application of vasoactive calcium channel modulators were quantified functionally (N/m²). All tested operation modes resulted in equal findings, whereas each mode features operation-related data analysis.}, language = {en} } @article{DigelTemizArtmannNishikawaetal.2004, author = {Digel, Ilya and Temiz Artmann, Ayseg{\"u}l and Nishikawa, K. and Artmann, Gerhard}, title = {Cluster air-ion effects on bacteria and moulds}, series = {Biomedizinische Technik. 49 (2004), H. Erg.-Bd. 2}, journal = {Biomedizinische Technik. 49 (2004), H. Erg.-Bd. 2}, isbn = {0932-4666}, pages = {1040 -- 1041}, year = {2004}, language = {en} } @article{DigelTemizArtmannNishikawaetal.2005, author = {Digel, Ilya and Temiz Artmann, Ayseg{\"u}l and Nishikawa, K. and Cook, M.}, title = {Bactericidal effects of plasma-generated cluster ions}, series = {Medical and Biological Engineering and Computing. 43 (2005), H. 6}, journal = {Medical and Biological Engineering and Computing. 43 (2005), H. 6}, isbn = {1741-0444}, pages = {800 -- 807}, year = {2005}, language = {en} } @article{DigelKernGeenenetal.2020, author = {Digel, Ilya and Kern, Inna and Geenen, Eva-Maria and Akimbekov, Nuraly S.}, title = {Dental plaque removal by ultrasonic toothbrushes}, series = {dentistry journal}, volume = {8}, journal = {dentistry journal}, number = {28}, publisher = {MDPI}, address = {Basel}, issn = {2304-6767}, doi = {10.3390/dj8010028}, pages = {1 -- 13}, year = {2020}, abstract = {With the variety of toothbrushes on the market, the question arises, which toothbrush is best suited to maintain oral health? This thematic review focuses first on plaque formation mechanisms and then on the plaque removal effectiveness of ultrasonic toothbrushes and their potential in preventing oral diseases like periodontitis, gingivitis, and caries. We overviewed the physical effects that occurred during brushing and tried to address the question of whether ultrasonic toothbrushes effectively reduced the microbial burden by increasing the hydrodynamic forces. The results of published studies show that electric toothbrushes, which combine ultrasonic and sonic (or acoustic and mechanic) actions, may have the most promising effect on good oral health. Existing ultrasonic/sonic toothbrush models do not significantly differ regarding the removal of dental biofilm and the reduction of gingival inflammation compared with other electrically powered toothbrushes, whereas the manual toothbrushes show a lower effectiveness.}, language = {en} } @article{DigelAkimbekovTuralievaetal.2013, author = {Digel, Ilya and Akimbekov, Nuraly S. and Turalieva, M. and Mansurov, Z. and Temiz Artmann, Ayseg{\"u}l and Eshibaev, A. and Zhubanova, A.}, title = {Usage of Carbonized Plant Wastes for Purification of Aqueous Solutions}, series = {Journal of Industrial Technology and Engineering}, volume = {2}, journal = {Journal of Industrial Technology and Engineering}, number = {07}, pages = {47 -- 54}, year = {2013}, language = {en} } @article{DigelKayserArtmann2008, author = {Digel, Ilya and Kayser, Peter and Artmann, Gerhard}, title = {Molecular processes in biological thermosensation}, series = {Journal of Biophysics. 2008 (2008)}, journal = {Journal of Biophysics. 2008 (2008)}, isbn = {1687-8000}, pages = {1 -- 9}, year = {2008}, language = {en} } @article{AlexyukBogoyavlenskiyAlexyuketal.2021, author = {Alexyuk, Madina and Bogoyavlenskiy, Andrey and Alexyuk, Pavel and Moldakhanov, Yergali and Berezin, Vladimir and Digel, Ilya}, title = {Epipelagic microbiome of the Small Aral Sea: Metagenomic structure and ecological diversity}, series = {MicrobiologyOpen}, volume = {10}, journal = {MicrobiologyOpen}, number = {1}, publisher = {Wiley}, address = {Weinheim}, issn = {2045-8827}, doi = {10.1002/mbo3.1142}, pages = {1 -- 10}, year = {2021}, abstract = {Microbial diversity studies regarding the aquatic communities that experienced or are experiencing environmental problems are essential for the comprehension of the remediation dynamics. In this pilot study, we present data on the phylogenetic and ecological structure of microorganisms from epipelagic water samples collected in the Small Aral Sea (SAS). The raw data were generated by massive parallel sequencing using the shotgun approach. As expected, most of the identified DNA sequences belonged to Terrabacteria and Actinobacteria (40\% and 37\% of the total reads, respectively). The occurrence of Deinococcus-Thermus, Armatimonadetes, Chloroflexi in the epipelagic SAS waters was less anticipated. Surprising was also the detection of sequences, which are characteristic for strict anaerobes—Ignavibacteria, hydrogen-oxidizing bacteria, and archaeal methanogenic species. We suppose that the observed very broad range of phylogenetic and ecological features displayed by the SAS reads demonstrates a more intensive mixing of water masses originating from diverse ecological niches of the Aral-Syr Darya River basin than presumed before.}, language = {en} } @article{AkimbekovMansurovJandosovetal.2013, author = {Akimbekov, Nuraly S. and Mansurov, Zulkhair and Jandosov, J. and Digel, Ilya and Gossmann, Matthias and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l and Zhubanova, Azhar A.}, title = {Wound healing activity of carbonized rice husk}, publisher = {Trans Tech Publications, Switzerland}, address = {B{\"a}ch}, year = {2013}, abstract = {The carbonized rice husk (CRH) was evaluated for its wound healing activity in rats using excision models. In this study, the influences of CRH on wound healing in rat skin in vivo and cellular behavior of human dermal fibroblasts in vitro were investigated. The obtained results showed that the CRH treatment promoted wound epithelization in rats and exhibited moderate inhibition of cell proliferation in vitro. CRH with lanolin oil treated wounds were found to epithelize faster as compared to controls.}, subject = {Wundheilung}, language = {en} } @article{ZhubanovaAknazarovMansurovetal.2010, author = {Zhubanova, Azhar A. and Aknazarov, S. K. and Mansurov, Zulkhair and Digel, Ilya and Kozhalakova, A. A. and Akimbekov, Nuraly S. and O'Heras, Carlos and Tazhibayeva, S. and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l}, title = {Adsorption of bacterial Lipopolysaccharides and blood plasma proteins on modified carbonized materials}, year = {2010}, abstract = {Bacterial lipopolysaccharides (endotoxins) show strong biological effects at very low concentrations in human beings and many animals when entering the blood stream. These include affecting structure and function of organs and cells, changing metabolic functions, raising body temperature, triggering the coagulation cascade, modifying hemodynamics and causing septic shock. Because of this toxicity, the removal of even minute amounts is essential for safe parenteral administration of drugs and also for septic shock patients' care. The absence of a general method for endotoxin removal from liquid interfaces urgently requires finding new methods and materials to overcome this gap. Nanostructured carbonized plant parts is a promising material that showed good adsorption properties due to its vast pore network and high surface area. The aim of this study was comparative measurement of endotoxin- and blood proteins-related adsorption rate and adsorption capacity for different carboneous materials produced at different temperatures and under different surface modifications. As a main surface modificator, positively cbarged polymer, polyethileneimine (PEl) was used. Activated carbon materials showed good adsorption properties for LPS and some proteins used in the experiments. During the batch experiments, several techniques (dust removal, autoclaving) were used and optimized for improving the material's adsorption behavior. Also, with the results obtained it was possible to differentiate the materials according to their adsorption capacity and kinetic characteristics. Modification of the surface apparently has not affected hemoglobin binding to the adsorbent's surface. Obtained adsorption isotherms can be used as a powerful tool for designing of future column-based setups for blood purification from LPS, which is especially important for septic shock treatment.}, subject = {Kohlenstofffaser}, language = {en} } @article{StadlerGarveyBocahutetal.2012, author = {Stadler, Andreas M. and Garvey, G. J. and Bocahut, A. and Sacquin-Mora, S. and Digel, Ilya and Schneider, G. J. and Natali, F. and Artmann, Gerhard and Zaccai, G.}, title = {Thermal fluctuations of haemoglobin from different species : adaptation to temperature via conformational dynamics}, series = {Journal of the Royal Society Interface}, volume = {9}, journal = {Journal of the Royal Society Interface}, number = {76}, publisher = {The Royal Society}, address = {London}, issn = {1742-5689}, doi = {10.1098/rsif.2012.0364}, pages = {2845 -- 2855}, year = {2012}, abstract = {Thermodynamic stability, configurational motions and internal forces of haemoglobin (Hb) of three endotherms (platypus, Ornithorhynchus anatinus; domestic chicken, Gallus gallus domesticus and human, Homo sapiens) and an ectotherm (salt water crocodile, Crocodylus porosus) were investigated using circular dichroism, incoherent elastic neutron scattering and coarse-grained Brownian dynamics simulations. The experimental results from Hb solutions revealed a direct correlation between protein resilience, melting temperature and average body temperature of the different species on the 0.1 ns time scale. Molecular forces appeared to be adapted to permit conformational fluctuations with a root mean square displacement close to 1.2 {\AA} at the corresponding average body temperature of the endotherms. Strong forces within crocodile Hb maintain the amplitudes of motion within a narrow limit over the entire temperature range in which the animal lives. In fully hydrated powder samples of human and chicken, Hb mean square displacements and effective force constants on the 1 ns time scale showed no differences over the whole temperature range from 10 to 300 K, in contrast to the solution case. A complementary result of the study, therefore, is that one hydration layer is not sufficient to activate all conformational fluctuations of Hb in the pico- to nanosecond time scale which might be relevant for biological function. Coarse-grained Brownian dynamics simulations permitted to explore residue-specific effects. They indicated that temperature sensing of human and chicken Hb occurs mainly at residues lining internal cavities in the β-subunits.}, language = {en} } @article{Dachwald2005, author = {Dachwald, Bernd}, title = {Optimal Solar Sail Trajectories for Missions to the Outer Solar System}, series = {Journal of guidance, control, and dynamics. 28 (2005), H. 6}, journal = {Journal of guidance, control, and dynamics. 28 (2005), H. 6}, isbn = {0162-3192}, pages = {1187 -- 1193}, year = {2005}, language = {en} } @article{Dachwald2005, author = {Dachwald, Bernd}, title = {Optimization of very-low-thrust trajectories using evolutionary neurocontrol}, series = {Acta Astronautica. 57 (2005), H. 2-8}, journal = {Acta Astronautica. 57 (2005), H. 2-8}, isbn = {0094-5765}, pages = {175 -- 185}, year = {2005}, language = {en} } @article{DachwaldSeboldt2008, author = {Dachwald, Bernd and Seboldt, Wolfgang}, title = {Solar Sails — Propellantless Propulsion for Near- and Medium-Term Deep-Space Missions / W. Seboldt ; B. Dachwald}, series = {Advanced Propulsion Systems and Technologies, Today to 2020 / Claudio Bruno (ed.) ... - (Progress in Astronautics and Aeronautics Series ; 223)}, journal = {Advanced Propulsion Systems and Technologies, Today to 2020 / Claudio Bruno (ed.) ... - (Progress in Astronautics and Aeronautics Series ; 223)}, publisher = {AIAA}, address = {Reston, Va.}, isbn = {978-1-56347-929-8}, pages = {460 S.}, year = {2008}, language = {en} } @article{SavitskayaKistaubayevaDigeletal.2017, author = {Savitskaya, I. S. and Kistaubayeva, A. S. and Digel, Ilya and Shokatayeva, D. H.}, title = {Physicochemical and Antibacterial Properties of Composite Films Based on Bacterial Cellulose and Chitosan for Wound Dressing Materials}, series = {Eurasian Chemico-Technological Journal}, volume = {19}, journal = {Eurasian Chemico-Technological Journal}, number = {3}, issn = {2522-4867}, doi = {10.18321/ectj670}, pages = {255 -- 264}, year = {2017}, language = {en} } @article{DachwaldOhndorf2007, author = {Dachwald, Bernd and Ohndorf, A.}, title = {1st ACT Global Trajectory Optimisation Competition : Results found at DLR}, series = {Acta Astronautica. 61 (2007), H. 9}, journal = {Acta Astronautica. 61 (2007), H. 9}, isbn = {0094-5765}, pages = {742 -- 752}, year = {2007}, language = {en} } @article{HeinEubanksLingametal.2022, author = {Hein, Andreas M. and Eubanks, T. Marshall and Lingam, Manasvi and Hibberd, Adam and Fries, Dan and Schneider, Jean and Kervella, Pierre and Kennedy, Robert and Perakis, Nikolaos and Dachwald, Bernd}, title = {Interstellar now! Missions to explore nearby interstellar objects}, series = {Advances in Space Research}, volume = {69}, journal = {Advances in Space Research}, number = {1}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0273-1177}, doi = {10.1016/j.asr.2021.06.052}, pages = {402 -- 414}, year = {2022}, abstract = {The recently discovered first hyperbolic objects passing through the Solar System, 1I/'Oumuamua and 2I/Borisov, have raised the question about near term missions to Interstellar Objects. In situ spacecraft exploration of these objects will allow the direct determination of both their structure and their chemical and isotopic composition, enabling an entirely new way of studying small bodies from outside our solar system. In this paper, we map various Interstellar Object classes to mission types, demonstrating that missions to a range of Interstellar Object classes are feasible, using existing or near-term technology. We describe flyby, rendezvous and sample return missions to interstellar objects, showing various ways to explore these bodies characterizing their surface, dynamics, structure and composition. Their direct exploration will constrain their formation and history, situating them within the dynamical and chemical evolution of the Galaxy. These mission types also provide the opportunity to explore solar system bodies and perform measurements in the far outer solar system.}, language = {en} } @article{DachwaldBallUlamecetal.2009, author = {Dachwald, Bernd and Ball, Andrew J. and Ulamec, Stephan and Price, Michael E.}, title = {A small mission for in situ exploration of a primitive binary near-Earth asteroid / Ball, Andrew J. ; Ulamec, Stephan ; Dachwald, Bernd ; Price, Michael E. ; [u.a.]}, series = {Advances in Space Research. 43 (2009), H. 2}, journal = {Advances in Space Research. 43 (2009), H. 2}, publisher = {Elsevier}, address = {Amsterdam}, isbn = {0273-1177}, pages = {317 -- 324}, year = {2009}, language = {en} } @article{AkimbekovDigelZhubanova2013, author = {Akimbekov, Nuraly S. and Digel, Ilya and Zhubanova, A. A.}, title = {Investigation the Influence of Carbonized Material Based On Rice Husk on Viability and Migration of Fibroblasts in T3B3 Cell Culture}, series = {KazNU Bulletin. Biology series}, volume = {59}, journal = {KazNU Bulletin. Biology series}, number = {3/1}, issn = {1563-0218}, pages = {20 -- 23}, year = {2013}, language = {en} } @article{DemirciKurulganDemirciTrzewiketal.2009, author = {Demirci, Taylan and Kurulgan Demirci, Eylem and Trzewik, J{\"u}rgen and Linder, Peter and Digel, Ilya and Artmann, Gerhard and Sakizli, Meral and Temiz Artmann, Ayseg{\"u}l}, title = {Gene expression profile analysis of 3T3/NIH fibroblasts after one hour mechanical stress}, series = {IUBMB Life. 61 (2009), H. 3}, journal = {IUBMB Life. 61 (2009), H. 3}, publisher = {Wiley-VCH}, address = {Weinheim}, isbn = {1521-6543}, pages = {311 -- 312}, year = {2009}, language = {en} } @article{DigelKurulganDemirciLinderetal.2007, author = {Digel, Ilya and Kurulgan Demirci, Eylem and Linder, Peter and Kayser, Peter}, title = {Decrease in extracellular collagen crosslinking after NMR magnetic field application in skin fibroblasts}, series = {Medical and Biological Engineering and Computing. 45 (2007), H. 1}, journal = {Medical and Biological Engineering and Computing. 45 (2007), H. 1}, isbn = {1741-0444}, pages = {91 -- 97}, year = {2007}, language = {en} } @article{LinderDigelTemizArtmannetal.2007, author = {Linder, Peter and Digel, Ilya and Temiz Artmann, Ayseg{\"u}l and Kayser, Peter and Porst, Dariusz and Artmann, Gerhard}, title = {High-throughput testing of mechanical forces generated in thin cell and tissue layers}, series = {Tissue Engineering. 13 (2007), H. 7}, journal = {Tissue Engineering. 13 (2007), H. 7}, isbn = {1076-3279}, pages = {1778 -- 1778}, year = {2007}, language = {en} } @article{AkimbekovDigelTastambeketal.2021, author = {Akimbekov, Nuraly S. and Digel, Ilya and Tastambek, Kuanysh T. and Sherelkhan, Dinara K. and Jussupova, Dariya B. and Altynbay, Nazym P.}, title = {Low-rank coal as a source of humic substances for soil amendment and fertility management}, series = {Agriculture}, volume = {11}, journal = {Agriculture}, number = {12}, publisher = {MDPI}, address = {Basel}, issn = {2077-0472}, doi = {10.3390/agriculture11121261}, pages = {25 Seiten}, year = {2021}, abstract = {Humic substances (HS), as important environmental components, are essential to soil health and agricultural sustainability. The usage of low-rank coal (LRC) for energy generation has declined considerably due to the growing popularity of renewable energy sources and gas. However, their potential as soil amendment aimed to maintain soil quality and productivity deserves more recognition. LRC, a highly heterogeneous material in nature, contains large quantities of HS and may effectively help to restore the physicochemical, biological, and ecological functionality of soil. Multiple emerging studies support the view that LRC and its derivatives can positively impact the soil microclimate, nutrient status, and organic matter turnover. Moreover, the phytotoxic effects of some pollutants can be reduced by subsequent LRC application. Broad geographical availability, relatively low cost, and good technical applicability of LRC offer the advantage of easy fulfilling soil amendment and conditioner requirements worldwide. This review analyzes and emphasizes the potential of LRC and its numerous forms/combinations for soil amelioration and crop production. A great benefit would be a systematic investment strategy implicating safe utilization and long-term application of LRC for sustainable agricultural production.}, language = {en} } @article{DachwaldKahleWie2006, author = {Dachwald, Bernd and Kahle, Ralph and Wie, Bong}, title = {Solar Sailing Kinetic Energy Impactor (KEI) Mission Design Tradeoffs for Impacting and Deflecting Asteroid 99942 Apophis}, series = {AIAA Guidance, Navigation, and Control Conference \& Exhibit - AIAA Atmospheric Flight Mechanics Conference \& Exhibit - AIAA Modeling and Simulation Technologies Conference \& Exhibit - AIAA/AAS Astrodynamics Specialist Conference \& Exhibit : [21 - 24 August 2006, Keystone, Colorado ; papers]. - (AIAA meeting papers on disc ; [11.]2006,19-20 )}, journal = {AIAA Guidance, Navigation, and Control Conference \& Exhibit - AIAA Atmospheric Flight Mechanics Conference \& Exhibit - AIAA Modeling and Simulation Technologies Conference \& Exhibit - AIAA/AAS Astrodynamics Specialist Conference \& Exhibit : [21 - 24 August 2006, Keystone, Colorado ; papers]. - (AIAA meeting papers on disc ; [11.]2006,19-20 )}, publisher = {American Institute of Aeronautics and Astronautics}, address = {Reston, Va.}, isbn = {1-56347-802-1}, pages = {1 -- 20}, year = {2006}, language = {en} } @article{DachwaldSeboldtMacdonaldetal.2005, author = {Dachwald, Bernd and Seboldt, Wolfgang and Macdonald, Malcolm and Mengali, Giovanni and Quatra, Alessandro A. and McInnes, Colin R. and Rios-Reyes, Leonel and Scheerers, Daniel J. and Wie, Bong and G{\"o}rlich, Marianne and Lura, Franz and Diedrich, Benjamin and Baturkin, Volodymyr and Coverstone, Victoria L. and Leipold, Manfred and Garbe, Gregory P.}, title = {Potential Solar Sail Degradation Effects on Trajectory and Attitude Control}, series = {AIAA Guidance, Navigation and Control Conference and Exhibit - AIAA Modeling and Simulation Technologies Conference and Exhibit - AIAA Atmospheric Flight Mechanics Conference and Exhibit : [San Francisco, California, 15 - 18 August 2005 ; papers]. - (AIAA meeting papers on disc ; [10.]2005,16-17)}, journal = {AIAA Guidance, Navigation and Control Conference and Exhibit - AIAA Modeling and Simulation Technologies Conference and Exhibit - AIAA Atmospheric Flight Mechanics Conference and Exhibit : [San Francisco, California, 15 - 18 August 2005 ; papers]. - (AIAA meeting papers on disc ; [10.]2005,16-17)}, publisher = {American Institute of Aeronautics and Astronautics}, address = {Reston, Va.}, isbn = {1-56347-765-3}, pages = {2 CD-ROMs}, year = {2005}, language = {en} } @article{ZerlinDigelStadleretal.2007, author = {Zerlin, Kay and Digel, Ilya and Stadler, Andreas M. and B{\"u}ldt, Georg and Zaccai, Guiseppe and Artmann, Gerhard}, title = {Dynamics and interactions of hemoglobin in human red blood cells and concentrated hemoglobin solutions}, series = {Regenerative medicine. 2 (2007), H. 5}, journal = {Regenerative medicine. 2 (2007), H. 5}, isbn = {1746-0751}, pages = {573 -- 573}, year = {2007}, language = {en} } @article{ZhantlessovaSavitskayaKistaubayevaetal.2022, author = {Zhantlessova, Sirina and Savitskaya, Irina and Kistaubayeva, Aida and Ignatova, Ludmila and Talipova, Aizhan and Pogrebnjak, Alexander and Digel, Ilya}, title = {Advanced "Green" prebiotic composite of bacterial cellulose/pullulan based on synthetic biology-powered microbial coculture strategy}, series = {Polymers}, volume = {14}, journal = {Polymers}, number = {15}, publisher = {MDPI}, address = {Basel}, issn = {2073-4360}, doi = {10.3390/polym14153224}, pages = {Artikel 3224}, year = {2022}, abstract = {Bacterial cellulose (BC) is a biopolymer produced by different microorganisms, but in biotechnological practice, Komagataeibacter xylinus is used. The micro- and nanofibrillar structure of BC, which forms many different-sized pores, creates prerequisites for the introduction of other polymers into it, including those synthesized by other microorganisms. The study aims to develop a cocultivation system of BC and prebiotic producers to obtain BC-based composite material with prebiotic activity. In this study, pullulan (PUL) was found to stimulate the growth of the probiotic strain Lactobacillus rhamnosus GG better than the other microbial polysaccharides gellan and xanthan. BC/PUL biocomposite with prebiotic properties was obtained by cocultivation of Komagataeibacter xylinus and Aureobasidium pullulans, BC and PUL producers respectively, on molasses medium. The inclusion of PUL in BC is proved gravimetrically by scanning electron microscopy and by Fourier transformed infrared spectroscopy. Cocultivation demonstrated a composite effect on the aggregation and binding of BC fibers, which led to a significant improvement in mechanical properties. The developed approach for "grafting" of prebiotic activity on BC allows preparation of environmentally friendly composites of better quality.}, language = {en} } @article{AkimbekovDigelSherelkhanetal.2020, author = {Akimbekov, Nuraly S. and Digel, Ilya and Sherelkhan, Dinara K. and Lutfor, Afzalunnessa B. and Razzaque, Mohammed S.}, title = {Vitamin D and the Host-Gut Microbiome: A Brief Overview}, series = {Acta Histochemica et Cytochemica}, volume = {53}, journal = {Acta Histochemica et Cytochemica}, number = {3}, publisher = {Japan Society of Histochemistry and Cytochemistry}, address = {Osaka}, issn = {1347-5800}, doi = {10.1267/ahc.20011}, pages = {33 -- 42}, year = {2020}, abstract = {There is a growing body of evidence for the effects of vitamin D on intestinal host-microbiome interactions related to gut dysbiosis and bowel inflammation. This brief review highlights the potential links between vitamin D and gut health, emphasizing the role of vitamin D in microbiological and immunological mechanisms of inflammatory bowel diseases. A comprehensive literature search was carried out in PubMed and Google Scholar using combinations of keywords "vitamin D," "intestines," "gut microflora," "bowel inflammation". Only articles published in English and related to the study topic are included in the review. We discuss how vitamin D (a) modulates intestinal microbiome function, (b) controls antimicrobial peptide expression, and (c) has a protective effect on epithelial barriers in the gut mucosa. Vitamin D and its nuclear receptor (VDR) regulate intestinal barrier integrity, and control innate and adaptive immunity in the gut. Metabolites from the gut microbiota may also regulate expression of VDR, while vitamin D may influence the gut microbiota and exert anti-inflammatory and immune-modulating effects. The underlying mechanism of vitamin D in the pathogenesis of bowel diseases is not fully understood, but maintaining an optimal vitamin D status appears to be beneficial for gut health. Future studies will shed light on the molecular mechanisms through which vitamin D and VDR interactions affect intestinal mucosal immunity, pathogen invasion, symbiont colonization, and antimicrobial peptide expression.}, language = {en} } @article{PeloniCeriottiDachwald2016, author = {Peloni, Alessandro and Ceriotti, Matteo and Dachwald, Bernd}, title = {Solar-sail trajectory design for a multiple near-earth-asteroid rendezvous mission}, series = {Journal of Guidance, Control, and Dynamics}, volume = {39}, journal = {Journal of Guidance, Control, and Dynamics}, number = {12}, publisher = {AIAA}, address = {Reston, Va.}, issn = {0731-5090}, doi = {10.2514/1.G000470}, pages = {2712 -- 2724}, year = {2016}, abstract = {The scientific interest for near-Earth asteroids as well as the interest in potentially hazardous asteroids from the perspective of planetary defense led the space community to focus on near-Earth asteroid mission studies. A multiple near-Earth asteroid rendezvous mission with close-up observations of several objects can help to improve the characterization of these asteroids. This work explores the design of a solar-sail spacecraft for such a mission, focusing on the search of possible sequences of encounters and the trajectory optimization. This is done in two sequential steps: a sequence search by means of a simplified trajectory model and a set of heuristic rules based on astrodynamics, and a subsequent optimization phase. A shape-based approach for solar sailing has been developed and is used for the first phase. The effectiveness of the proposed approach is demonstrated through a fully optimized multiple near-Earth asteroid rendezvous mission. The results show that it is possible to visit five near-Earth asteroids within 10 years with near-term solar-sail technology.}, language = {en} } @article{PogorelovaRogachevAkimbekovetal.2024, author = {Pogorelova, Natalia and Rogachev, Evgeniy and Akimbekov, Nuraly S. and Digel, Ilya}, title = {Effect of dehydration method on the micro- and nanomorphological properties of bacterial cellulose produced by Medusomyces gisevii on different substrates}, series = {Journal of materials science}, volume = {2024}, journal = {Journal of materials science}, publisher = {Springer Science + Business Media}, address = {Dordrecht}, issn = {1573-4803 (Online)}, doi = {10.1007/s10853-024-09596-3}, pages = {13 Seiten}, year = {2024}, abstract = {Many important properties of bacterial cellulose (BC), such as moisture absorption capacity, elasticity and tensile strength, largely depend on its structure. This paper presents a study on the effect of the drying method on BC films produced by Medusomyces gisevii using two different procedures: room temperature drying (RT, (24 ± 2 °C, humidity 65 ± 1\%, dried until a constant weight was reached) and freeze-drying (FD, treated at - 75 °C for 48 h). BC was synthesized using one of two different carbon sources—either glucose or sucrose. Structural differences in the obtained BC films were evaluated using atomic force microscopy (AFM), scanning electron microscopy (SEM), and X-ray diffraction. Macroscopically, the RT samples appeared semi-transparent and smooth, whereas the FD group exhibited an opaque white color and sponge-like structure. SEM examination showed denser packing of fibrils in FD samples while RT-samples displayed smaller average fiber diameter, lower surface roughness and less porosity. AFM confirmed the SEM observations and showed that the FD material exhibited a more branched structure and a higher surface roughness. The samples cultivated in a glucose-containing nutrient medium, generally displayed a straight and ordered shape of fibrils compared to the sucrose-derived BC, characterized by a rougher and wavier structure. The BC films dried under different conditions showed distinctly different crystallinity degrees, whereas the carbon source in the culture medium was found to have a relatively small effect on the BC crystallinity.}, language = {en} } @article{SavitskayaZhantlessovaKistaubayevaetal.2023, author = {Savitskaya, Irina and Zhantlessova, Sirina and Kistaubayeva, Aida and Ignatova, Ludmila and Shokatayeva, Dina and Sinyavsky, Yuriy and Kushugulova, Almagul and Digel, Ilya}, title = {Prebiotic cellulose-pullulan matrix as a "vehicle" for probiotic biofilm delivery to the host large intestine}, series = {Polymers}, journal = {Polymers}, number = {16(1)}, publisher = {MDPI}, address = {Basel}, doi = {10.3390/polym16010030}, pages = {Artikel 30}, year = {2023}, abstract = {This study describes the development of a new combined polysaccharide-matrix-based technology for the immobilization of Lactobacillus rhamnosus GG (LGG) bacteria in biofilm form. The new composition allows for delivering the bacteria to the digestive tract in a manner that improves their robustness compared with planktonic cells and released biofilm cells. Granules consisting of a polysaccharide matrix with probiotic biofilms (PMPB) with high cell density (>9 log CFU/g) were obtained by immobilization in the optimized nutrient medium. Successful probiotic loading was confirmed by fluorescence microscopy and scanning electron microscopy. The developed prebiotic polysaccharide matrix significantly enhanced LGG viability under acidic (pH 2.0) and bile salt (0.3\%) stress conditions. Enzymatic extract of feces, mimicking colon fluid in terms of cellulase activity, was used to evaluate the intestinal release of probiotics. PMPB granules showed the ability to gradually release a large number of viable LGG cells in the model colon fluid. In vivo, the oral administration of PMPB granules in rats resulted in the successful release of probiotics in the colon environment. The biofilm-forming incubation method of immobilization on a complex polysaccharide matrix tested in this study has shown high efficacy and promising potential for the development of innovative biotechnologies.}, language = {en} } @article{AkimbekovZhubanovaMansurovetal.2010, author = {Akimbekov, Nuraly S. and Zhubanova, A. A. and Mansurov, Z. A. and Digel, Ilya and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l}, title = {Use of Carbonized Rise Shell for the local treatment of wounds}, series = {Eurasian ChemTech Journal}, volume = {12}, journal = {Eurasian ChemTech Journal}, number = {2}, publisher = {Institute of Combustion Problems}, address = {Almaty}, issn = {2522-4867}, doi = {10.18321/ectj35}, pages = {133 -- 138}, year = {2010}, abstract = {On the model of musculocutaneous wound in rats, the effect of applicative sorption by carbonized rise shell (CRS) on the healing of festering wound was studied. It has been shown, that cytological changes end with rapid scar formation. The use of CRS at the period of severe purulent wound contributes to its favorable course, prevents the development of complications of the animals from sepsis.}, language = {en} } @article{AkimbekovDigelO’Herasetal.2015, author = {Akimbekov, Nuraly S. and Digel, Ilya and O'Heras, C. and Tastambek, K.T. and Savitskaya, I.S. and Ualyeva, P.S. and Mansurov, Z.A. and Zhubanova, A.A.}, title = {Adsorption of bacterial lipopol ysaccharides on carbonized ri ce husks obtained in the batch experiments}, series = {KazNU Bulletin. Biology series}, volume = {60}, journal = {KazNU Bulletin. Biology series}, number = {No 1/2}, issn = {1563-0218}, pages = {144 -- 148}, year = {2015}, language = {en} } @article{DachwaldMengaliQuartaetal.2006, author = {Dachwald, Bernd and Mengali, Giovanni and Quarta, Alessandrao A. and Macdonald, Malcolm}, title = {Parametric Model and Optimal Control of Solar Sails with Optical Degradation}, series = {Journal of guidance, control, and dynamics. 29 (2006), H. 5}, journal = {Journal of guidance, control, and dynamics. 29 (2006), H. 5}, isbn = {0162-3192}, pages = {1170 -- 1178}, year = {2006}, language = {en} } @article{KraemerDaabMuelleretal.2013, author = {Kr{\"a}mer, Stefan and Daab, Dominique Jonas and M{\"u}ller, Brigitte and Wagner, Tobias and Baader, Fabian and Hessel, Joana and Gdalewitsch, Georg and Plescher, Engelbert and Dachwald, Bernd and Wahle, Michael and Gierse, Andreas and Vetter, Rudolf and Pf{\"u}tzenreuter, Lysan}, title = {Development and flight-testing of a system to isolate vibrations for microgravity experiments on sounding rockets}, series = {21st ESA Symposium on Rocket and Balloon Research}, journal = {21st ESA Symposium on Rocket and Balloon Research}, pages = {1 -- 8}, year = {2013}, language = {en} } @article{LyonsMikuckiGermanetal.2019, author = {Lyons, W. Berry and Mikucki, Jill A. and German, Laura A. and Welch, Kathleen A. and Welch, Susan A. and Gardener, Christopher B. and Tulaczyk, Slawek M. and Pettit, Erin C. and Kowalski, Julia and Dachwald, Bernd}, title = {The Geochemistry of Englacial Brine from Taylor Glacier, Antarctica}, series = {Journal of Geophysical Research: Biogeosciences}, journal = {Journal of Geophysical Research: Biogeosciences}, publisher = {Wiley}, address = {Hoboken}, issn = {2169-8961}, doi = {10.1029/2018JG004411}, year = {2019}, language = {en} } @article{Dachwald2004, author = {Dachwald, Bernd}, title = {Optimal Solar Sail Trajectories for Missions to the Outer Solar System}, series = {22nd AIAA Applied Aerodynamics Conference and Exhibit - AIAA/AAS Astrodynamics Specialist Conference and Exhibit - AIAA Guidance, Navigation, and Control Conference and Exhibit - AIAA Modeling and Simulation Technologies Conference and Exhibit - AIAA Atmospheric Flight Mechanics Conference and Exhibit : 16 - 19 August 2004, Providence, Rhode Island / American Institute of Aeronautics and Astronautics. - (AIAA meeting papers on disc ; 2004,14-15)}, journal = {22nd AIAA Applied Aerodynamics Conference and Exhibit - AIAA/AAS Astrodynamics Specialist Conference and Exhibit - AIAA Guidance, Navigation, and Control Conference and Exhibit - AIAA Modeling and Simulation Technologies Conference and Exhibit - AIAA Atmospheric Flight Mechanics Conference and Exhibit : 16 - 19 August 2004, Providence, Rhode Island / American Institute of Aeronautics and Astronautics. - (AIAA meeting papers on disc ; 2004,14-15)}, publisher = {American Inst. of Aeronautics and Astronautics}, address = {Reston, Va.}, pages = {2 CD-ROMs}, year = {2004}, language = {en} } @article{DigelZhubanovaNojimaetal.2004, author = {Digel, Ilya and Zhubanova, Azhar A. and Nojima, H. and Artmann, Gerhard}, title = {The use of bactericidal effects of cluster ions generated by plasma in medical biotechnology}, series = {Biotechnologija : teorija i praktika (2004)}, journal = {Biotechnologija : teorija i praktika (2004)}, isbn = {1028-9399}, pages = {46 -- 52}, year = {2004}, language = {en} } @article{ArtmannZerlinDigeletal.2007, author = {Artmann, Gerhard and Zerlin, Kay and Digel, Ilya and Stadler, Andreas M.}, title = {Physical discontinuities at body temperature in human red blood cells / Artmann, GM ; Zerlin, K ; Digel, I ; Stadler, A ; Zaccai, G ; Temiz, AA}, series = {Tissue Engineering. 13 (2007), H. 7}, journal = {Tissue Engineering. 13 (2007), H. 7}, isbn = {1076-3279}, pages = {1778 -- 1778}, year = {2007}, language = {en} } @article{TurlybekulyPogrebnjakSukhodubetal.2019, author = {Turlybekuly, Amanzhol and Pogrebnjak, Alexander and Sukhodub, L. F. and Sukhodub, Liudmyla B. and Kistaubayeva, A. S. and Savitskaya, Irina and Shokatayeva, D. H. and Bondar, Oleksandr V. and Shaimardanov, Z. K. and Plotnikov, Sergey V. and Shaimardanova, B. H. and Digel, Ilya}, title = {Synthesis, characterization, in vitro biocompatibility and antibacterial properties study of nanocomposite materials based on hydroxyapatite-biphasic ZnO micro- and nanoparticles embedded in Alginate matrix}, series = {Materials Science and Engineering C}, volume = {104}, journal = {Materials Science and Engineering C}, number = {Article number 109965}, publisher = {Elsevier}, address = {Amsterdam}, doi = {10.1016/j.msec.2019.109965}, year = {2019}, language = {en} } @article{Dachwald2003, author = {Dachwald, Bernd}, title = {Verwendung eines neuronalen Reglers und evolution{\"a}rer Algorithmen zur Berechnung optimaler interplanetarer Sonnenseglerbahnen}, series = {Deutscher Luft- und Raumfahrtkongress 2003 : M{\"u}nchen, 17. bis 20. November 2003, Motto: 100 Jahre Motorflug - 112 Jahre Menschenflug: Visionen gestalten Zukunft / Deutsche Gesellschaft f{\"u}r Luft- und Raumfahrt - Lilienthal-Oberth e.V. (DGLR). [Red.: Peter Brandt (verantwortlich)]. - Bd. 1. - (Jahrbuch ... der Deutschen Gesellschaft f{\"u}r Luft- und Raumfahrt)}, journal = {Deutscher Luft- und Raumfahrtkongress 2003 : M{\"u}nchen, 17. bis 20. November 2003, Motto: 100 Jahre Motorflug - 112 Jahre Menschenflug: Visionen gestalten Zukunft / Deutsche Gesellschaft f{\"u}r Luft- und Raumfahrt - Lilienthal-Oberth e.V. (DGLR). [Red.: Peter Brandt (verantwortlich)]. - Bd. 1. - (Jahrbuch ... der Deutschen Gesellschaft f{\"u}r Luft- und Raumfahrt)}, address = {Bonn}, pages = {211 -- 218}, year = {2003}, language = {de} } @article{DachwaldWie2005, author = {Dachwald, Bernd and Wie, Bong}, title = {Solar Sail Trajectory Optimization for Intercepting, Impacting, and Deflecting Near-Earth Asteroids}, series = {AIAA Guidance, Navigation and Control Conference and Exhibit - AIAA Modeling and Simulation Technologies Conference and Exhibit - AIAA Atmospheric Flight Mechanics Conference and Exhibit : [San Francisco, California, 15 - 18 August 2005 ; papers]. - (AIAA meeting papers on disc ; [10.]2005,16-17)}, journal = {AIAA Guidance, Navigation and Control Conference and Exhibit - AIAA Modeling and Simulation Technologies Conference and Exhibit - AIAA Atmospheric Flight Mechanics Conference and Exhibit : [San Francisco, California, 15 - 18 August 2005 ; papers]. - (AIAA meeting papers on disc ; [10.]2005,16-17)}, publisher = {American Institute of Aeronautics and Astronautics}, address = {Reston, Va.}, isbn = {1-56347-765-3}, pages = {2 CD-ROMs}, year = {2005}, language = {en} } @article{DachwaldCarnelliVasile2009, author = {Dachwald, Bernd and Carnelli, Ian and Vasile, Massimiliano}, title = {Evolutionary Neurocontrol: A Novel Method for Low-Thrust Gravity-Assist Trajectory Optimization / Carnelli, Ian ; Dachwald, Bernd ; Vasile, Massimiliano}, series = {Journal of guidance control and dynamics. 32 (2009), H. 2}, journal = {Journal of guidance control and dynamics. 32 (2009), H. 2}, publisher = {AIAA}, address = {Reston, Va.}, isbn = {0731-5090}, pages = {616 -- 625}, year = {2009}, language = {en} } @article{SeefeldtDachwald2021, author = {Seefeldt, Patric and Dachwald, Bernd}, title = {Temperature increase on folded solar sail membranes}, series = {Advances in Space Research}, volume = {67}, journal = {Advances in Space Research}, number = {9}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0273-1177}, doi = {10.1016/j.asr.2020.09.026}, pages = {2688 -- 2695}, year = {2021}, language = {en} } @article{LeimenaArtmannDachwaldetal.2010, author = {Leimena, W. and Artmann, Gerhard and Dachwald, Bernd and Temiz Artmann, Ayseg{\"u}l and Gossmann, Matthias and Digel, Ilya}, title = {Feasibility of an in-situ microbial decontamination of an ice-melting probe}, series = {Eurasian Chemico-Technological Journal. 12 (2010), H. 2}, journal = {Eurasian Chemico-Technological Journal. 12 (2010), H. 2}, isbn = {1562-3920}, pages = {145 -- 150}, year = {2010}, language = {en} } @article{BassamDigelHescheleretal.2013, author = {Bassam, Rasha and Digel, Ilya and Hescheler, J{\"u}rgen and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard}, title = {Effects of spermine NONOate and ATP on protein aggregation: light scattering evidences}, series = {BMC Biophysics}, journal = {BMC Biophysics}, publisher = {BioMed Central}, address = {London}, isbn = {2046-1682}, url = {http://nbn-resolving.de/10.1186/2046-1682-6-1}, pages = {1 -- 14}, year = {2013}, language = {en} } @article{TuraliyevaYeshibaevSaparbekovaetal.2016, author = {Turaliyeva, M. and Yeshibaev, A. and Saparbekova, A. and Akynova, L. and Abildayeva, R. and Sadenova, M. and Sartayeva, K. and Schieffer, Andre and Digel, Ilya}, title = {Species composition and injuriousness of stranger xylophilous fauna affecting indigenous urban dendroflora of Central Asia}, series = {Asian journal of microbiology, biotechnology \& environmental sciences : AJMBES}, volume = {18}, journal = {Asian journal of microbiology, biotechnology \& environmental sciences : AJMBES}, number = {2}, publisher = {EM International}, issn = {0972-3005}, pages = {359 -- 366}, year = {2016}, abstract = {At the present time, one of the most serious environmental problems of Central Asia and South Kazakhstan is the ongoing large-scale deterioration of principal urban tree populations. Several major centers of massive spread of invasive plant pests have been found in urban dendroflora of this region. The degree of damage of seven most wide-spread aboriginal tree species was found to range from 21.4±1.1 to 85.4±1.8\%. In particular, the integrity of the native communities of sycamore (Platanus spp.), willow (Salix spp.), poplar (Populus spp.) and elm (Ulmus spp.) is highly endangered. Our taxonomic analysis of the most dangerous tree pests of the region has revealed them as neobiontic xylophilous insects such as Cossus cossus L. (Order: Lepidoptera L.) Monochamus urussovi Fisch., Monochamus sutor L., Acanthocinus aedelis L. and {\~N}etonia aureate L. (Order: Coleoptera L.). We relate the origin of this threatening trend with the import of industrial wood in the mid 90’s of the last century that was associated with high degree of the constructional work in the region. Because of the absence of efficient natural predators of the pest species, the application of microbiological methods of the pest control and limitation is suggested.}, language = {en} } @article{GermanMikuckiWelchetal.2021, author = {German, Laura and Mikucki, Jill A. and Welch, Susan A. and Welch, Kathleen A. and Lutton, Anthony and Dachwald, Bernd and Kowalski, Julia and Heinen, Dirk and Feldmann, Marco and Francke, Gero and Espe, Clemens and Lyons, W. Berry}, title = {Validation of sampling antarctic subglacial hypersaline waters with an electrothermal ice melting probe (IceMole) for environmental analytical geochemistry}, series = {International Journal of Environmental Analytical Chemistry}, volume = {101}, journal = {International Journal of Environmental Analytical Chemistry}, number = {15}, publisher = {Taylor \& Francis}, address = {London}, issn = {0306-7319}, doi = {10.1080/03067319.2019.1704750}, pages = {2654 -- 2667}, year = {2021}, abstract = {Geochemical characterisation of hypersaline waters is difficult as high concentrations of salts hinder the analysis of constituents at low concentrations, such as trace metals, and the collection of samples for trace metal analysis in natural waters can be easily contaminated. This is particularly the case if samples are collected by non-conventional techniques such as those required for aquatic subglacial environments. In this paper we present the first analysis of a subglacial brine from Taylor Valley, (~ 78°S), Antarctica for the trace metals: Ba, Co, Mo, Rb, Sr, V, and U. Samples were collected englacially using an electrothermal melting probe called the IceMole. This probe uses differential heating of a copper head as well as the probe's sidewalls and an ice screw at the melting head to move through glacier ice. Detailed blanks, meltwater, and subglacial brine samples were collected to evaluate the impact of the IceMole and the borehole pump, the melting and collection process, filtration, and storage on the geochemistry of the samples collected by this device. Comparisons between melt water profiles through the glacier ice and blank analysis, with published studies on ice geochemistry, suggest the potential for minor contributions of some species Rb, As, Co, Mn, Ni, NH4+, and NO2-+NO3- from the IceMole. The ability to conduct detailed chemical analyses of subglacial fluids collected with melting probes is critical for the future exploration of the hundreds of deep subglacial lakes in Antarctica.}, language = {en} } @article{DachwaldSeboldt2003, author = {Dachwald, Bernd and Seboldt, Wolfgang}, title = {Solar sailcraft of the first generation technology development / Seboldt, Wolfgang ; Dachwald, Bernd}, year = {2003}, language = {en} } @article{VuStaat2004, author = {Vu, Duc-Khoi and Staat, Manfred}, title = {An algorithm for shakedown analysis of structure with temperature dependent yield stress}, year = {2004}, abstract = {This work is an attempt to answer the question: How to use convex programming in shakedown analysis of structures made of materials with temperature-dependent properties. Based on recently established shakedown theorems and formulations, a dual relationship between upper and lower bounds of the shakedown limit load is found, an algorithmfor shakedown analysis is proposed. While the original problem is neither convex nor concave, the algorithm presented here has the advantage of employing convex programming tools.}, subject = {Einspielen }, language = {en} } @article{CiritsisHorbachStaatetal.2018, author = {Ciritsis, Alexander and Horbach, Andreas and Staat, Manfred and Kuhl, Christiane K. and Kraemer, Nils Andreas}, title = {Porosity and tissue integration of elastic mesh implants evaluated in vitro and in vivo}, series = {Journal of Biomedical Materials Research: Part B: Applied Biomaterials}, volume = {106}, journal = {Journal of Biomedical Materials Research: Part B: Applied Biomaterials}, number = {2}, publisher = {Wiley}, address = {New York, NY}, issn = {1552-4981}, doi = {10.1002/jbm.b.33877}, pages = {827 -- 833}, year = {2018}, abstract = {Purpose In vivo, a loss of mesh porosity triggers scar tissue formation and restricts functionality. The purpose of this study was to evaluate the properties and configuration changes as mesh deformation and mesh shrinkage of a soft mesh implant compared with a conventional stiff mesh implant in vitro and in a porcine model. Material and Methods Tensile tests and digital image correlation were used to determine the textile porosity for both mesh types in vitro. A group of three pigs each were treated with magnetic resonance imaging (MRI) visible conventional stiff polyvinylidene fluoride meshes (PVDF) or with soft thermoplastic polyurethane meshes (TPU) (FEG Textiltechnik mbH, Aachen, Germany), respectively. MRI was performed with a pneumoperitoneum at a pressure of 0 and 15 mmHg, which resulted in bulging of the abdomen. The mesh-induced signal voids were semiautomatically segmented and the mesh areas were determined. With the deformations assessed in both mesh types at both pressure conditions, the porosity change of the meshes after 8 weeks of ingrowth was calculated as an indicator of preserved elastic properties. The explanted specimens were examined histologically for the maturity of the scar (collagen I/III ratio). Results In TPU, the in vitro porosity increased constantly, in PVDF, a loss of porosity was observed under mild stresses. In vivo, the mean mesh areas of TPU were 206.8 cm2 (± 5.7 cm2) at 0 mmHg pneumoperitoneum and 274.6 cm2 (± 5.2 cm2) at 15 mmHg; for PVDF the mean areas were 205.5 cm2 (± 8.8 cm2) and 221.5 cm2 (± 11.8 cm2), respectively. The pneumoperitoneum-induced pressure increase resulted in a calculated porosity increase of 8.4\% for TPU and of 1.2\% for PVDF. The mean collagen I/III ratio was 8.7 (± 0.5) for TPU and 4.7 (± 0.7) for PVDF. Conclusion The elastic properties of TPU mesh implants result in improved tissue integration compared to conventional PVDF meshes, and they adapt more efficiently to the abdominal wall. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 827-833, 2018.}, language = {en} } @article{LeschingerBirgelHackletal.2019, author = {Leschinger, Tim and Birgel, Stefan and Hackl, Michael and Staat, Manfred and M{\"u}ller, Lars Peter and Wegmann, Kilian}, title = {A musculoskeletal shoulder simulation of moment arms and joint reaction forces after medialization of the supraspinatus footprint in rotator cuff repair}, series = {Computer Methods in Biomechanics and Biomedical Engineering}, journal = {Computer Methods in Biomechanics and Biomedical Engineering}, number = {Early view}, publisher = {Taylor \& Francis}, address = {London}, doi = {10.1080/10255842.2019.1572749}, year = {2019}, language = {en} } @article{StaatHeitzerLangetal.2005, author = {Staat, Manfred and Heitzer, M. and Lang, H. and Wirtz, K.}, title = {Direct Finite Element Route for Design-by-Analysis of Pressure Components}, series = {International Journal of Pressure Vessels and Piping. 82 (2005), H. 1}, journal = {International Journal of Pressure Vessels and Piping. 82 (2005), H. 1}, isbn = {0308-0161}, pages = {61 -- 67}, year = {2005}, language = {en} } @article{Dachwald2004, author = {Dachwald, Bernd}, title = {Low-Thrust Trajectory Optimization and Interplanetary Mission Analysis Using Evolutionary Neurocontrol}, series = {Deutscher Luft- und Raumfahrtkongress 2004 : Dresden, 20. bis 23. September 2004, Motto: Luft- und Raumfahrt - Br{\"u}cke f{\"u}r eine wissensbasierte Gesellschaft / Deutsche Gesellschaft f{\"u}r Luft- und Raumfahrt - Lilienthal-Oberth e.V. (DGLR). [Red.: Peter Brandt (verantwortlich)]. - Bd. 2. - (Jahrbuch ... der Deutschen Gesellschaft f{\"u}r Luft- und Raumfahrt)}, journal = {Deutscher Luft- und Raumfahrtkongress 2004 : Dresden, 20. bis 23. September 2004, Motto: Luft- und Raumfahrt - Br{\"u}cke f{\"u}r eine wissensbasierte Gesellschaft / Deutsche Gesellschaft f{\"u}r Luft- und Raumfahrt - Lilienthal-Oberth e.V. (DGLR). [Red.: Peter Brandt (verantwortlich)]. - Bd. 2. - (Jahrbuch ... der Deutschen Gesellschaft f{\"u}r Luft- und Raumfahrt)}, address = {Bonn}, pages = {917 -- 926}, year = {2004}, language = {en} } @article{LoebSchartnerDachwaldetal.2012, author = {Loeb, Horst Wolfgang and Schartner, Karl-Heinz and Dachwald, Bernd and Ohndorf, Andreas and Seboldt, Wolfgang}, title = {Interstellar heliopause probe}, series = {Труды МАИ}, journal = {Труды МАИ}, number = {60}, publisher = {Moskauer Staatliches Luftfahrtinstitut (МАИ)}, address = {Moskau}, pages = {2 -- 2}, year = {2012}, abstract = {There is common agreement within the scientific community that in order to understand our local galactic environment it will be necessary to send a spacecraft into the region beyond the solar wind termination shock. Considering distances of 200 AU for a new mission, one needs a spacecraft traveling at a speed of close to 10 AU/yr in order to keep the mission duration in the range of less than 25 yrs, a transfer time postulated by European Space Agency (ESA). Two propulsion options for the mission have been proposed and discussed so far: the solar sail propulsion and the ballistic/radioisotope-electric propulsion (REP). As a further alternative, we here investigate a combination of solar-electric propulsion (SEP) and REP. The SEP stage consists of six 22-cms diameter RIT-22 ion thrusters working with a high specific impulse of 7377 s corresponding to a positive grid voltage of 5 kV. Solar power of 53 kW at begin of mission (BOM) is provided by a lightweight solar array.}, language = {en} } @article{PogorelovaRogachevDigeletal.2020, author = {Pogorelova, Natalia and Rogachev, Evgeniy and Digel, Ilya and Chernigova, Svetlana and Nardin, Dmitry}, title = {Bacterial Cellulose Nanocomposites: Morphology and Mechanical Properties}, series = {Materials}, volume = {13}, journal = {Materials}, number = {12}, publisher = {MDPI}, address = {Basel}, isbn = {1996-1944}, doi = {10.3390/ma13122849}, pages = {1 -- 16}, year = {2020}, abstract = {Bacterial cellulose (BC) is a promising material for biomedical applications due to its unique properties such as high mechanical strength and biocompatibility. This article describes the microbiological synthesis, modification, and characterization of the obtained BC-nanocomposites originating from symbiotic consortium Medusomyces gisevii. Two BC-modifications have been obtained: BC-Ag and BC-calcium phosphate (BC-Ca3(PO4)2). Structure and physicochemical properties of the BC and its modifications were investigated by scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), atomic force microscopy (AFM), and infrared Fourier spectroscopy as well as by measurements of mechanical and water holding/absorbing capacities. Topographic analysis of the surface revealed multicomponent thick fibrils (150-160 nm in diameter and about 15 µm in length) constituted by 50-60 nm nanofibrils weaved into a left-hand helix. Distinctive features of Ca-phosphate-modified BC samples were (a) the presence of 500-700 nm entanglements and (b) inclusions of Ca3(PO4)2 crystals. The samples impregnated with Ag nanoparticles exhibited numerous roundish inclusions, about 110 nm in diameter. The boundaries between the organic and inorganic phases were very distinct in both cases. The Ag-modified samples also showed a prominent waving pattern in the packing of nanofibrils. The obtained BC gel films possessed water-holding capacity of about 62.35 g/g. However, the dried (to a constant mass) BC-films later exhibited a low water absorption capacity (3.82 g/g). It was found that decellularized BC samples had 2.4 times larger Young's modulus and 2.2 times greater tensile strength as compared to dehydrated native BC films. We presume that this was caused by molecular compaction of the BC structure.}, language = {en} } @article{DachwaldSeboldtRichter2003, author = {Dachwald, Bernd and Seboldt, Wolfgang and Richter, L.}, title = {Multiple Rendezvous and Sample Return Missions to Near-Earth Asteroids Using Solar Sailcraft}, series = {Proceedings of the Fifth IAA International Conference on Low Cost Planetary Missions : 24 - 26 September 2003, ESTEC, Noordwijk, the Netherlands / [comp. by R. A. Harris]}, journal = {Proceedings of the Fifth IAA International Conference on Low Cost Planetary Missions : 24 - 26 September 2003, ESTEC, Noordwijk, the Netherlands / [comp. by R. A. Harris]}, publisher = {ESA}, address = {Noordwijk}, isbn = {92-9092-853-0}, pages = {351 -- 358}, year = {2003}, language = {en} } @article{KohlerKirschnerHermannsStaatetal.2018, author = {Kohler, Annette and Kirschner-Hermanns, Ruth and Staat, Manfred and Brehmer, Bernhard}, title = {Pathogenese, funktionelle und anatomische Aspekte der weiblichen Belastungsinkontinenz}, series = {Aktuelle Urologie}, volume = {49}, journal = {Aktuelle Urologie}, number = {1}, publisher = {Thieme}, address = {Stuttgart}, issn = {1438-8820}, doi = {10.1055/s-0043-120616}, pages = {47 -- 51}, year = {2018}, abstract = {Der vorliegende Artikel fokussiert sich auf die weibliche Belastungsinkontinenz als Insuffizienz der Speicherfunktion der Blase, auch wenn im klinischen Alltag die Harninkontinenz der Frau h{\"a}ufig verschiedene Ursachen hat und insbesondere eine Belastungsinkontinenz im Alter und bei neurologischer Komorbidit{\"a}t nur selten isoliert vorkommt. Das kleine Becken der Frau ist sowohl als Funktions- als auch als strukturelle Einheit zu betrachten. Dabei unterliegen bei der Frau Blase, Harnr{\"o}hre, Geb{\"a}rmutter und Enddarm sowie die muskul{\"a}ren und ligament{\"o}sen Strukturen des kleinen Beckens durch Fertilit{\"a}tsphase, m{\"o}gliche Schwangerschaften, Geburten und Menopausen-Phase, {\"u}ber das „normale Altern" hinaus, gravierenden Ver{\"a}nderungen. This article focuses on female stress incontinence in the form of pelvic floor dysfunction and urethral sphincter deficiency, although isolated stress incontinence accounts for less than half of all incontinence cases. Especially in women of old age and those with neurological comorbidities, the causes of incontinence are mostly multifactorial. Also it has to be considered that the female bladder, urethra, uterus and rectum as well as the muscular and ligamentous structures of the female pelvis minor are affected by phases of fertility, possible pregnancies, births and menopause in addition to the normal ageing process.}, language = {de} } @article{HacklAndermahrStaatetal.2017, author = {Hackl, M. and Andermahr, J. and Staat, Manfred and Bremer, I. and Borggrefe, J. and Prescher, A. and M{\"u}ller, L. P. and Wegmann, K.}, title = {Suture button reconstruction of the central band of the interosseous membrane in Essex-Lopresti lesions: a comparative biomechanical investigation}, series = {The Journal of Hand Surgery (European Volume)}, volume = {42}, journal = {The Journal of Hand Surgery (European Volume)}, number = {4}, publisher = {Sage}, address = {London}, issn = {2043-6289 (Online)}, doi = {10.1177/1753193416665943}, pages = {370 -- 376}, year = {2017}, language = {en} } @article{TopcuMadabhushiStaat2022, author = {Top{\c{c}}u, Murat and Madabhushi, Gopal S.P. and Staat, Manfred}, title = {A generalized shear-lag theory for elastic stress transfer between matrix and fibres having a variable radius}, series = {International Journal of Solids and Structures}, volume = {239-240}, journal = {International Journal of Solids and Structures}, number = {Art. No. 111464}, publisher = {Elsevier}, address = {New York, NY}, issn = {0020-7683}, doi = {10.1016/j.ijsolstr.2022.111464}, year = {2022}, abstract = {A generalized shear-lag theory for fibres with variable radius is developed to analyse elastic fibre/matrix stress transfer. The theory accounts for the reinforcement of biological composites, such as soft tissue and bone tissue, as well as for the reinforcement of technical composite materials, such as fibre-reinforced polymers (FRP). The original shear-lag theory proposed by Cox in 1952 is generalized for fibres with variable radius and with symmetric and asymmetric ends. Analytical solutions are derived for the distribution of axial and interfacial shear stress in cylindrical and elliptical fibres, as well as conical and paraboloidal fibres with asymmetric ends. Additionally, the distribution of axial and interfacial shear stress for conical and paraboloidal fibres with symmetric ends are numerically predicted. The results are compared with solutions from axisymmetric finite element models. A parameter study is performed, to investigate the suitability of alternative fibre geometries for use in FRP.}, language = {en} } @article{BhattaraiHorbachStaatetal.2022, author = {Bhattarai, Aroj and Horbach, Andreas and Staat, Manfred and Kowalczyk, Wojciech and Tran, Thanh Ngoc}, title = {Virgin passive colon biomechanics and a literature review of active contraction constitutive models}, series = {Biomechanics}, volume = {2}, journal = {Biomechanics}, number = {2}, publisher = {MDPI}, address = {Basel}, issn = {2673-7078}, doi = {10.3390/biomechanics2020013}, pages = {138 -- 157}, year = {2022}, abstract = {The objective of this paper is to present our findings on the biomechanical aspects of the virgin passive anisotropic hyperelasticity of the porcine colon based on equibiaxial tensile experiments. Firstly, the characterization of the intestine tissues is discussed for a nearly incompressible hyperelastic fiber-reinforced Holzapfel-Gasser-Ogden constitutive model in virgin passive loading conditions. The stability of the evaluated material parameters is checked for the polyconvexity of the adopted strain energy function using positive eigenvalue constraints of the Hessian matrix with MATLAB. The constitutive material description of the intestine with two collagen fibers in the submucosal and muscular layer each has been implemented in the FORTRAN platform of the commercial finite element software LS-DYNA, and two equibiaxial tensile simulations are presented to validate the results with the optical strain images obtained from the experiments. Furthermore, this paper also reviews the existing models of the active smooth muscle cells, but these models have not been computationally studied here. The review part shows that the constitutive models originally developed for the active contraction of skeletal muscle based on Hill's three-element model, Murphy's four-state cross-bridge chemical kinetic model and Huxley's sliding-filament hypothesis, which are mainly used for arteries, are appropriate for numerical contraction numerical analysis of the large intestine.}, language = {en} } @article{AbelKahmannMellonetal.2020, author = {Abel, Alexander and Kahmann, Stephanie Lucina and Mellon, Stephen and Staat, Manfred and Jung, Alexander}, title = {An open-source tool for the validation of finite element models using three-dimensional full-field measurements}, series = {Medical Engineering \& Physics}, volume = {77}, journal = {Medical Engineering \& Physics}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1350-4533}, doi = {10.1016/j.medengphy.2019.10.015}, pages = {125 -- 129}, year = {2020}, abstract = {Three-dimensional (3D) full-field measurements provide a comprehensive and accurate validation of finite element (FE) models. For the validation, the result of the model and measurements are compared based on two respective point-sets and this requires the point-sets to be registered in one coordinate system. Point-set registration is a non-convex optimization problem that has widely been solved by the ordinary iterative closest point algorithm. However, this approach necessitates a good initialization without which it easily returns a local optimum, i.e. an erroneous registration. The globally optimal iterative closest point (Go-ICP) algorithm has overcome this drawback and forms the basis for the presented open-source tool that can be used for the validation of FE models using 3D full-field measurements. The capability of the tool is demonstrated using an application example from the field of biomechanics. Methodological problems that arise in real-world data and the respective implemented solution approaches are discussed.}, language = {en} } @article{AndingTabazaStaatetal.2013, author = {Anding, Ralf and Tabaza, Ruth and Staat, Manfred and Trenz, Eva and Lohmann, Philipp and Klinge, Uwe and Kirschner-Hermanns, Ruth}, title = {Introducing a method of in vitro testing of different anchoring systems used for female incontinence and prolapse surgery}, series = {BioMed research international}, volume = {Vol. 2013}, journal = {BioMed research international}, issn = {1110-7251 (E-Journal); 2314-6141 (E-Journal); 1110-7243 (Print); 2314-6133 (Print)}, pages = {Article ID 401417}, year = {2013}, language = {en} } @article{HacklLeschingerStaatetal.2016, author = {Hackl, Michael and Leschinger, T. and Staat, Manfred and M{\"u}ller, Lars-Peter and Wegmann, Kilian}, title = {Reconstruction of the interosseous membrane in the Essex Lopresti lesion — a biomechanical evaluation}, series = {Knee surgery, sports traumatology, arthroscopy}, volume = {Volume 24}, journal = {Knee surgery, sports traumatology, arthroscopy}, number = {Supplement 1}, publisher = {Springer}, address = {Berlin}, issn = {0942-2056}, doi = {10.1007/s00167-016-4080-7}, pages = {130 -- 131}, year = {2016}, abstract = {Surgical reconstruction of the interosseous membrane (IOM) could restore longitudinal forearm stability to avoid persisting disability due to capituloradial and ulnocarpal impingement in Essex Lopresti lesions. This biomechanical study aimed to assess longitudinal forearm stability of intact specimens, after sectioning of the IOM and after reconstruction with a TightRope construct using either a single or double bundle technique.}, language = {en} } @article{AkimbekovQiaoDigeletal.2020, author = {Akimbekov, Nuraly S. and Qiao, Xiaohui and Digel, Ilya and Abdieva, Gulzhamal and Ualieva, Perizat and Zhubanova, Azhar}, title = {The effect of leonardite-derived amendments on soil microbiome structure and potato yield}, series = {Agriculture}, volume = {10}, journal = {Agriculture}, number = {Art. 147}, publisher = {MDPI}, address = {Basel}, doi = {10.3390/agriculture10050147}, pages = {1 -- 17}, year = {2020}, abstract = {Humic substances originating from various organic matters can ameliorate soil properties, stimulate plant growth, and improve nutrient uptake. Due to the low calorific heating value, leonardite is rather unsuitable as fuel. However, it may serve as a potential source of humic substances. This study was aimed at characterizing the leonardite-based soil amendments and examining the effect of their application on the soil microbial community, as well as on potato growth and tuber yield. A high yield (71.1\%) of humic acid (LHA) from leonardite has been demonstrated. Parental leonardite (PL) and LHA were applied to soil prior to potato cultivation. The 16S rRNA sequencing of soil samples revealed distinct relationships between microbial community composition and the application of leonardite-based soil amendments. Potato tubers were planted in pots in greenhouse conditions. The tubers were harvested at the mature stage for the determination of growth and yield parameters. The results demonstrated that the LHA treatments had a significant effect on increasing potato growth (54.9\%) and tuber yield (66.4\%) when compared to the control. The findings highlight the importance of amending leonardite-based humic products for maintaining the biogeochemical stability of soils, for keeping their healthy microbial community structure, and for increasing the agronomic productivity of potato plants.}, language = {en} } @article{BlomeSeboldtDachwaldetal.2004, author = {Blome, Hans-Joachim and Seboldt, Wolfgang and Dachwald, Bernd and Richter, Lutz}, title = {Proposal for an integrated European Space Exploration Study}, series = {Space Debris and Space Traffic Management Symposium 2004 : proceedings of the International Academy of Astronautics Space Debris and Space Traffic Management Symposium, held in conjunction with the 55th International Astronautical Congress (IAC), October 4 - 8, 2004, Vancouver, British Columbia, Canada / ed. by Joerg Bendisch}, journal = {Space Debris and Space Traffic Management Symposium 2004 : proceedings of the International Academy of Astronautics Space Debris and Space Traffic Management Symposium, held in conjunction with the 55th International Astronautical Congress (IAC), October 4 - 8, 2004, Vancouver, British Columbia, Canada / ed. by Joerg Bendisch}, publisher = {Univelt}, address = {San Diego, Calif.}, isbn = {0-87703-523-7}, pages = {XI, 432 S. : Ill., graph. Darst.}, year = {2004}, language = {en} } @article{KuehnHaugnerStaatetal.2004, author = {K{\"u}hn, Raoul-Roman and Haugner, Werner and Staat, Manfred and Sponagel, Stefan}, title = {A Two Phase Mixture Model based on Bone Observation}, year = {2004}, abstract = {An optimization method is developed to describe the mechanical behaviour of the human cancellous bone. The method is based on a mixture theory. A careful observation of the behaviour of the bone material leads to the hypothesis that the bone density is controlled by the principal stress trajectories (Wolff's law). The basic idea of the developed method is the coupling of a scalar value via an eigenvalue problem to the principal stress trajectories. On the one hand this theory will permit a prediction of the reaction of the biological bone structure after the implantation of a prosthesis, on the other hand it may be useful in engineering optimization problems. An analytical example shows its efficiency.}, subject = {Knochen}, language = {en} } @article{SchoenrockMuckeltHastermannetal.2024, author = {Schoenrock, Britt and Muckelt, Paul E. and Hastermann, Maria and Albracht, Kirsten and MacGregor, Robert and Martin, David and Gunga, Hans-Christian and Salanova, Michele and Stokes, Maria J. and Warner, Martin B. and Blottner, Dieter}, title = {Muscle stiffness indicating mission crew health in space}, series = {Scientific Reports}, volume = {14}, journal = {Scientific Reports}, number = {Article number: 4196}, publisher = {Springer Nature}, address = {London}, issn = {2045-2322}, doi = {10.1038/s41598-024-54759-6}, pages = {13 Seiten}, year = {2024}, abstract = {Muscle function is compromised by gravitational unloading in space affecting overall musculoskeletal health. Astronauts perform daily exercise programmes to mitigate these effects but knowing which muscles to target would optimise effectiveness. Accurate inflight assessment to inform exercise programmes is critical due to lack of technologies suitable for spaceflight. Changes in mechanical properties indicate muscle health status and can be measured rapidly and non-invasively using novel technology. A hand-held MyotonPRO device enabled monitoring of muscle health for the first time in spaceflight (> 180 days). Greater/maintained stiffness indicated countermeasures were effective. Tissue stiffness was preserved in the majority of muscles (neck, shoulder, back, thigh) but Tibialis Anterior (foot lever muscle) stiffness decreased inflight vs. preflight (p < 0.0001; mean difference 149 N/m) in all 12 crewmembers. The calf muscles showed opposing effects, Gastrocnemius increasing in stiffness Soleus decreasing. Selective stiffness decrements indicate lack of preservation despite daily inflight countermeasures. This calls for more targeted exercises for lower leg muscles with vital roles as ankle joint stabilizers and in gait. Muscle stiffness is a digital biomarker for risk monitoring during future planetary explorations (Moon, Mars), for healthcare management in challenging environments or clinical disorders in people on Earth, to enable effective tailored exercise programmes.}, language = {en} } @article{ZhenLiangStaatetal.2024, author = {Zhen, Manghao and Liang, Yunpei and Staat, Manfred and Li, Quanqui and Li, Jianbo}, title = {Discontinuous fracture behaviors and constitutive model of sandstone specimens containing non-parallel prefabricated fissures under uniaxial compression}, series = {Theoretical and Applied Fracture Mechanics}, volume = {131}, journal = {Theoretical and Applied Fracture Mechanics}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0167-8442}, doi = {10.1016/j.tafmec.2024.104373}, pages = {Artikel 104373}, year = {2024}, abstract = {The deformation and damage laws of non-homogeneous irregular structural planes in rocks are the basis for studying the stability of rock engineering. To investigate the damage characteristics of rock containing non-parallel fissures, uniaxial compression tests and numerical simulations were conducted on sandstone specimens containing three non-parallel fissures inclined at 0°, 45° and 90° in this study. The characteristics of crack initiation and crack evolution of fissures with different inclinations were analyzed. A constitutive model for the discontinuous fractures of fissured sandstone was proposed. The results show that the fracture behaviors of fissured sandstone specimens are discontinuous. The stress-strain curves are non-smooth and can be divided into nonlinear crack closure stage, linear elastic stage, plastic stage and brittle failure stage, of which the plastic stage contains discontinuous stress drops. During the uniaxial compression test, the middle or ends of 0° fissures were the first to crack compared to 45° and 90° fissures. The end with small distance between 0° and 45° fissures cracked first, and the end with large distance cracked later. After the final failure, 0° fissures in all specimens were fractured, while 45° and 90° fissures were not necessarily fractured. Numerical simulation results show that the concentration of compressive stress at the tips of 0°, 45° and 90° fissures, as well as the concentration of tensile stress on both sides, decreased with the increase of the inclination angle. A constitutive model for the discontinuous fractures of fissured sandstone specimens was derived by combining the logistic model and damage mechanic theory. This model can well describe the discontinuous drops of stress and agrees well with the whole processes of the stress-strain curves of the fissured sandstone specimens.}, language = {en} } @article{HacklBuessKammerlohretal.2021, author = {Hackl, Michael and Buess, Eduard and Kammerlohr, Sandra and Nacov, Julia and Staat, Manfred and Leschinger, Tim and M{\"u}ller, Lars P. and Wegmann, Kilian}, title = {A "comma sign"-directed subscapularis repair in anterosuperior rotator cuff tears yields biomechanical advantages in a cadaveric model}, series = {The american journal of sports medicine}, volume = {49}, journal = {The american journal of sports medicine}, number = {12}, publisher = {Sage}, address = {London}, issn = {1552-3365}, doi = {10.1177/03635465211031506}, pages = {3212 -- 3217}, year = {2021}, abstract = {Background: Additional stabilization of the "comma sign" in anterosuperior rotator cuff repair has been proposed to provide biomechanical benefits regarding stability of the repair. Purpose: This in vitro investigation aimed to investigate the influence of a comma sign-directed reconstruction technique for anterosuperior rotator cuff tears on the primary stability of the subscapularis tendon repair. Study Design: Controlled laboratory study. Methods: A total of 18 fresh-frozen cadaveric shoulders were used in this study. Anterosuperior rotator cuff tears (complete full-thickness tear of the supraspinatus and subscapularis tendons) were created, and supraspinatus repair was performed with a standard suture bridge technique. The subscapularis was repaired with either a (1) single-row or (2) comma sign technique. A high-resolution 3D camera system was used to analyze 3-mm and 5-mm gap formation at the subscapularis tendon-bone interface upon incremental cyclic loading. Moreover, the ultimate failure load of the repair was recorded. A Mann-Whitney test was used to assess significant differences between the 2 groups. Results: The comma sign repair withstood significantly more loading cycles than the single-row repair until 3-mm and 5-mm gap formation occurred (P≤ .047). The ultimate failure load did not reveal any significant differences when the 2 techniques were compared (P = .596). Conclusion: The results of this study show that additional stabilization of the comma sign enhanced the primary stability of subscapularis tendon repair in anterosuperior rotator cuff tears. Although this stabilization did not seem to influence the ultimate failure load, it effectively decreased the micromotion at the tendon-bone interface during cyclic loading. Clinical Relevance: The proposed technique for stabilization of the comma sign has shown superior biomechanical properties in comparison with a single-row repair and might thus improve tendon healing. Further clinical research will be necessary to determine its influence on the functional outcome.}, language = {en} } @article{PeloniDachwaldCeriotti2017, author = {Peloni, Alessandro and Dachwald, Bernd and Ceriotti, Matteo}, title = {Multiple near-earth asteroid rendezvous mission: Solar-sailing options}, series = {Advances in Space Research}, journal = {Advances in Space Research}, number = {In Press, Corrected Proof}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0273-1177}, doi = {10.1016/j.asr.2017.10.017}, year = {2017}, language = {en} } @article{DachwaldSeboldtLoebetal.2008, author = {Dachwald, Bernd and Seboldt, Wolfgang and Loeb, H. W. and Schartner, Karl-Heinz}, title = {Main Belt Asteroid Sample Return Mission Using Solar Electric Propulsion}, series = {Acta Astronautica. 63 (2008), H. 1-4}, journal = {Acta Astronautica. 63 (2008), H. 1-4}, isbn = {0094-5765}, pages = {91 -- 101}, year = {2008}, language = {en} } @article{KezerashviliDachwald2021, author = {Kezerashvili, Roman Ya and Dachwald, Bernd}, title = {Preface: Solar sailing: Concepts, technology, and missions II}, series = {Advances in Space Research}, volume = {67}, journal = {Advances in Space Research}, number = {9}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0273-1177}, doi = {10.1016/j.asr.2021.01.037}, pages = {2559 -- 2560}, year = {2021}, language = {en} } @article{DachwaldOhndorfSeboldt2005, author = {Dachwald, Bernd and Ohndorf, A. and Seboldt, Wolfgang}, title = {Optimierung der Lageregelung von Raumfahrzeugen mit Niedrigschubantrieb mittels evolution{\"a}rer neuronaler Regler / A. Ohndorf ; B. Dachwald ; W. Seboldt}, series = {Deutscher Luft- und Raumfahrtkongress 2005 : Friedrichshafen, 26. bis 29. September 2005, Motto: Luft- und Raumfahrt - Grenzen {\"u}berwinden, Horizonte erweitern / Deutsche Gesellschaft f{\"u}r Luft- und Raumfahrt - Lilienthal-Oberth e.V. (DGLR). [Red.: Peter Brandt (verantwortlich)]. Bd. 3. - (Jahrbuch ... der Deutschen Gesellschaft f{\"u}r Luft- und Raumfahrt}, journal = {Deutscher Luft- und Raumfahrtkongress 2005 : Friedrichshafen, 26. bis 29. September 2005, Motto: Luft- und Raumfahrt - Grenzen {\"u}berwinden, Horizonte erweitern / Deutsche Gesellschaft f{\"u}r Luft- und Raumfahrt - Lilienthal-Oberth e.V. (DGLR). [Red.: Peter Brandt (verantwortlich)]. Bd. 3. - (Jahrbuch ... der Deutschen Gesellschaft f{\"u}r Luft- und Raumfahrt}, publisher = {DGLR}, address = {Bonn}, pages = {1971 -- 1978}, year = {2005}, language = {de} } @article{SpietzSproewitzSeefeldtetal.2021, author = {Spietz, Peter and Spr{\"o}witz, Tom and Seefeldt, Patric and Grundmann, Jan Thimo and Jahnke, Rico and Mikschl, Tobias and Mikulz, Eugen and Montenegro, Sergio and Reershemius, Siebo and Renger, Thomas and Ruffer, Michael and Sasaki, Kaname and Sznajder, Maciej and T{\´o}th, Norbert and Ceriotti, Matteo and Dachwald, Bernd and Macdonald, Malcolm and McInnes, Colin and Seboldt, Wolfgang and Quantius, Dominik and Bauer, Waldemar and Wiedemann, Carsten and Grimm, Christian D. and Hercik, David and Ho, Tra-Mi and Lange, Caroline and Schmitz, Nicole}, title = {Paths not taken - The Gossamer roadmap's other options}, series = {Advances in Space Research}, volume = {67}, journal = {Advances in Space Research}, number = {9}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0273-1177}, doi = {10.1016/j.asr.2021.01.044}, pages = {2912 -- 2956}, year = {2021}, language = {en} } @article{DachwaldBaturkinCoverstoneetal.2006, author = {Dachwald, Bernd and Baturkin, Volodymyr and Coverstone, Victoria L. and Dietrich, Benjamin and Garbe, Gregory P. and G{\"o}rlich, Marianne and Leipold, Manfred and Lura, Franz and Macdonald, Malcolm and McInnes, Colin R. and Mengali, Giovanni and Quatra, Alessandro A. and Rios-Reyes, Leonel and Scheeres, Daniel J. and Seboldt, Wolfgang and Wie, Bong}, title = {Potential Effects of Optical Solar Sail Degradation on Interplanetary Trajectory Design}, series = {Astrodynamics 2005 : proceedings of the AAS/AIAA astrodynamics conference held August 7 - 11, 2005, South Lake Tahoe, California / ed. by Bobby G. Williams. - Pt. 3. - (Advances in the astronautical sciences ; 123,3)}, journal = {Astrodynamics 2005 : proceedings of the AAS/AIAA astrodynamics conference held August 7 - 11, 2005, South Lake Tahoe, California / ed. by Bobby G. Williams. - Pt. 3. - (Advances in the astronautical sciences ; 123,3)}, publisher = {Univelt}, address = {San Diego, Calif.}, isbn = {0-87703-527-X}, pages = {2569 -- 2592}, year = {2006}, language = {en} } @article{DachwaldSeboldtRichter2006, author = {Dachwald, Bernd and Seboldt, Wolfgang and Richter, L.}, title = {Multiple rendezvous and sample return missions to near-Earth objects using solar sailcraft / Dachwald, B. ; Seboldt, W. ; Richter, L.}, series = {Acta Astronautica. 59 (2006), H. 8-11}, journal = {Acta Astronautica. 59 (2006), H. 8-11}, isbn = {0094-5765}, pages = {768 -- 776}, year = {2006}, language = {en} } @article{AkimbekovDigelAbdievaetal.2021, author = {Akimbekov, Nuraly S. and Digel, Ilya and Abdieva, Gulzhamal and Ualieva, Perizat and Tastambek, Kuanysh}, title = {Lignite biosolubilization and bioconversion by Bacillus sp.: the collation of analytical data}, series = {Biofuels}, volume = {12}, journal = {Biofuels}, number = {3}, publisher = {Taylor \& Francis}, address = {London}, issn = {1759-7277}, pages = {247 -- 258}, year = {2021}, abstract = {The vast metabolic potential of microbes in brown coal (lignite) processing and utilization can greatly contribute to innovative approaches to sustainable production of high-value products from coal. In this study, the multi-faceted and complex coal biosolubilization process by Bacillus sp. RKB 7 isolate from the Kazakhstan coal-mining soil is reported, and the derived products are characterized. Lignite solubilization tests performed for surface and suspension cultures testify to the formation of numerous soluble lignite-derived substances. Almost 24\% of crude lignite (5\% w/v) was solubilized within 14 days under slightly alkaline conditions (pH 8.2). FTIR analysis revealed various functional groups in the obtained biosolubilization products. Analyses of the lignite-derived humic products by UV-Vis and fluorescence spectrometry as well as elemental analysis yielded compatible results indicating the emerging products had a lower molecular weight and degree of aromaticity. Furthermore, XRD and SEM analyses were used to evaluate the biosolubilization processes from mineralogical and microscopic points of view. The findings not only contribute to a deeper understanding of microbe-mineral interactions in coal environments, but also contribute to knowledge of coal biosolubilization and bioconversion with regard to sustainable production of humic substances. The detailed and comprehensive analyses demonstrate the huge biotechnological potential of Bacillus sp. for agricultural productivity and environmental health.}, language = {en} } @article{DigelAkimbekovRogachevetal.2023, author = {Digel, Ilya and Akimbekov, Nuraly S. and Rogachev, Evgeniy and Pogorelova, Natalia}, title = {Bacterial cellulose produced by Medusomyces gisevii on glucose and sucrose: biosynthesis and structural properties}, series = {Cellulose}, journal = {Cellulose}, publisher = {Springer Science + Business Media}, address = {Dordrecht}, issn = {1572-882X (Online)}, doi = {10.1007/s10570-023-05592-z}, pages = {15 Seiten}, year = {2023}, abstract = {In this work, the effects of carbon sources and culture media on the production and structural properties of bacterial cellulose (BC) synthesized by Medusomyces gisevii have been studied. The culture medium was composed of different initial concentrations of glucose or sucrose dissolved in 0.4\% extract of plain green tea. Parameters of the culture media (titratable acidity, substrate conversion degree etc.) were monitored daily for 20 days of cultivation. The BC pellicles produced on different carbon sources were characterized in terms of biomass yield, crystallinity and morphology by field emission scanning electron microscopy (FE-SEM), atomic force microscopy and X-ray diffraction. Our results showed that Medusomyces gisevii had higher BC yields in media with sugar concentrations close to 10 g L-1 after a 18-20 days incubation period. Glucose in general lead to a higher BC yield (173 g L-1) compared to sucrose (163.5 g L-1). The BC crystallinity degree and surface roughness were higher in the samples synthetized from sucrose. Obtained FE-SEM micrographs show that the BC pellicles synthesized in the sucrose media contained densely packed tangles of cellulose fibrils whereas the BC produced in the glucose media displayed rather linear geometry of the BC fibrils without noticeable aggregates.}, language = {en} } @article{TuraliyevaYeshibaevDigeletal.2014, author = {Turaliyeva, M. and Yeshibaev, A. and Digel, Ilya and Elibayeva, G. and Sydykova, A. and Uspabayeva, A. and Dosybayeva, G. and Zhylysbayeva, A. and Lakhanova, K.}, title = {Molecular-genetic identification of emerged novel invasive pathogens of Asiatic Elm Ulmus pumila L}, series = {Life science journal}, volume = {11}, journal = {Life science journal}, number = {Spec. iss. 5s}, publisher = {Marsland Press}, address = {New York}, issn = {1097-8135}, doi = {10.7537/marslsj1105s14.33}, pages = {171 -- 175}, year = {2014}, abstract = {The dwarf elm Ulmus pumila L. (Ulmaceae) is one of indigenous species of flora in Kazakhstan and forms a basis of dendroflora in virtually all settlements of the region. In the past decade, multiple outbreaks of previously unknown diseases of the small-leaved elm have been registered. In our study, by the molecular-genetic analysis it was found that the pathogens responsible for the outbreaks are microfungi belonging to the genus Fusarium - F. solani and F. oxysporum. The nucleotide sequences (ITS regions) isolated from the diseased trees showed very high similarity with the GenBank control numbers EU625403.1 and FJ478128.1 (100.0 and 99.0 \% respectively). Oncoming research will focus on the search of natural microbial antagonists of the discovered phytopathogens.}, language = {en} } @article{ZhubanovaDigelNojimaetal.2007, author = {Zhubanova, Azhar A. and Digel, Ilya and Nojima, H. and Artmann, Gerhard}, title = {The use of bactericidal effects of cluster ions generated by plasma in medical biotechnology}, year = {2007}, abstract = {The most of conventional methods of air purification use the power of a fan to draw in air and pass it through a filter. The problem of bacterial contamination of inner parts of such a type of air conditioners in some cases draws attention towards alternative air-cleaning systems. Some manufacturers offer to use the ozone's bactericidal and deodorizing effects, but the wide spreading of such systems is restricted by the fact that toxic effects of ozone in respect of human beings are well known. In 2000 Sharp Inc. introduced "Plasma Cluster Ions (PCI)" air purification technology, which uses plasma discharge to generate cluster ions (I 0-14 ). This technology has been developed for those customers that are conscious about health and hygiene. In our experiments, we focused on some principal aspects of plasma-generated ions application - time-dependency and irreversibility of bactericidal action, spatial and kinetic characteristics of emitted cluster particles, their chemical targets in the microbial cells.}, subject = {Clusterion}, language = {en} } @article{Dachwald2004, author = {Dachwald, Bernd}, title = {Evolutionary Neurocontrol: A Smart Method for Global Optimization of Low-Thrust Trajectories}, series = {22nd AIAA Applied Aerodynamics Conference and Exhibit - AIAA/AAS Astrodynamics Specialist Conference and Exhibit - AIAA Guidance, Navigation, and Control Conference and Exhibit - AIAA Modeling and Simulation Technologies Conference and Exhibit - AIAA Atmospheric Flight Mechanics Conference and Exhibit : 16 - 19 August 2004, Providence, Rhode Island / American Institute of Aeronautics and Astronautics. - (AIAA meeting papers on disc ; 2004,14-15)}, journal = {22nd AIAA Applied Aerodynamics Conference and Exhibit - AIAA/AAS Astrodynamics Specialist Conference and Exhibit - AIAA Guidance, Navigation, and Control Conference and Exhibit - AIAA Modeling and Simulation Technologies Conference and Exhibit - AIAA Atmospheric Flight Mechanics Conference and Exhibit : 16 - 19 August 2004, Providence, Rhode Island / American Institute of Aeronautics and Astronautics. - (AIAA meeting papers on disc ; 2004,14-15)}, publisher = {American Inst. of Aeronautics and Astronautics}, address = {Reston, Va.}, pages = {2 CD-ROMs}, year = {2004}, language = {en} } @article{HeiligersSchoutetensDachwald2021, author = {Heiligers, Jeannette and Schoutetens, Frederic and Dachwald, Bernd}, title = {Photon-sail equilibria in the alpha centauri system}, series = {Journal of Guidance, Control, and Dynamics}, volume = {44}, journal = {Journal of Guidance, Control, and Dynamics}, number = {5}, issn = {1533-3884}, doi = {10.2514/1.G005446}, pages = {1053 -- 1061}, year = {2021}, language = {en} } @article{KozhalakovaZhubanovaMansurovetal.2010, author = {Kozhalakova, A. A. and Zhubanova, Azhar A. and Mansurov, Z. A. and Digel, Ilya and Tazhibayeva, S. M. and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l}, title = {Adsorption of bacterial lipopolysaccharides on carbonized rice shell}, series = {Science of Central Asia (2010)}, journal = {Science of Central Asia (2010)}, pages = {50 -- 54}, year = {2010}, language = {en} } @article{GrundmannDachwaldGrimmetal.2015, author = {Grundmann, Jan Thimo and Dachwald, Bernd and Grimm, Christian D. and Kahle, Ralph and Koch, Aaron Dexter and Krause, Christian and Lange, Caroline and Quantius, Dominik and Ulamec, Stephan}, title = {Spacecraft for Hypervelocity Impact Research - An Overview of Capabilities, Constraints and the Challenges of Getting There}, series = {Procedia Engineering}, volume = {Vol. 103}, journal = {Procedia Engineering}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1877-7058}, doi = {10.1016/j.proeng.2015.04.021}, pages = {151 -- 158}, year = {2015}, language = {en} }