@inproceedings{SchoeningAbouzarWagneretal.2006, author = {Sch{\"o}ning, Michael Josef and Abouzar, Maryam H. and Wagner, Torsten and N{\"a}ther, Niko and Rolka, David and Yoshinobu, Tatsuo and Kloock, Joachim P. and Turek, Monika and Ingebrandt, Sven and Poghossian, Arshak}, title = {A semiconductor-based field-effect platform for (bio-)chemical and physical sensors: From capacitive EIS sensors and LAPS over ISFETs to nano-scale devices}, series = {MRS Proceedings}, booktitle = {MRS Proceedings}, doi = {10.1557/PROC-0952-F08-02}, pages = {1 -- 9}, year = {2006}, language = {en} } @article{TurekKeusgenPoghossianetal.2008, author = {Turek, M. and Keusgen, M. and Poghossian, Arshak and Mulchandani, A. and Wang, J. and Sch{\"o}ning, Michael Josef}, title = {Enzyme-modified electrolyte-insulator-semiconductor sensors}, series = {Journal of Contemporary Physics. 43 (2008), H. 2}, journal = {Journal of Contemporary Physics. 43 (2008), H. 2}, isbn = {1934-9378}, pages = {82 -- 85}, year = {2008}, language = {en} } @article{PoghossianIngebrandtYeungetal.2004, author = {Poghossian, Arshak and Ingebrandt, S. and Yeung, C.-K. and Offenh{\"a}usser, A. and Sch{\"o}ning, Michael Josef}, title = {Microsensors based on ion-sensitive field-effect transistors for biomedical applications}, series = {Biomedizinische Technik. 49 (2004), H. 2}, journal = {Biomedizinische Technik. 49 (2004), H. 2}, isbn = {0932-4666}, pages = {1036 -- 1037}, year = {2004}, language = {en} } @article{BaeckerBegingBisellietal.2009, author = {B{\"a}cker, Matthias and Beging, Stefan and Biselli, Manfred and Poghossian, Arshak and Wang, J. and Zang, Werner and Wagner, Patrick and Sch{\"o}ning, Michael Josef}, title = {Concept for a solid-state multi-parameter sensor system for cell-culture monitoring}, series = {Electrochimica Acta. 54 (2009), H. 25 Sp. Iss. SI}, journal = {Electrochimica Acta. 54 (2009), H. 25 Sp. Iss. SI}, publisher = {Elsevier}, address = {Amsterdam}, isbn = {0013-4686}, pages = {6107 -- 6112}, year = {2009}, language = {en} } @article{BuniatyanMatirosyanAbouzaretal.2009, author = {Buniatyan, Vahe V. and Matirosyan, N. and Abouzar, Maryam H. and Schubert, J. and Zander, W. and Gevorgian, S. and Sch{\"o}ning, Michael Josef and Poghossian, Arshak}, title = {Capacitive field-effect pH sensor based on an electrolyte-ferroelectric-insulator-semiconductor structure}, series = {SENSOR 2009 : : 14th International Conference on Sensors, Technologies, Electronics and Applications; N{\"u}rnberg, Germany, 26 - 28 May 2009; proceedings; [part of] Sensor + Test Conference 2009 / AMA, Fachverband f{\"u}r Sensorik e.V}, journal = {SENSOR 2009 : : 14th International Conference on Sensors, Technologies, Electronics and Applications; N{\"u}rnberg, Germany, 26 - 28 May 2009; proceedings; [part of] Sensor + Test Conference 2009 / AMA, Fachverband f{\"u}r Sensorik e.V}, publisher = {AMA Service}, address = {Wunstorf}, isbn = {9783981099355}, pages = {317 -- 322}, year = {2009}, language = {en} } @article{PoghossianBerndsenSchoening2003, author = {Poghossian, Arshak and Berndsen, Lars and Sch{\"o}ning, Michael Josef}, title = {Chemical sensor as physical sensor: ISFET-based flowvelocity, flow-direction and diffusion-coefficient sensor}, series = {Sensors and Actuators B. 95 (2003), H. 1-3}, journal = {Sensors and Actuators B. 95 (2003), H. 1-3}, isbn = {0925-4005}, pages = {384 -- 390}, year = {2003}, language = {en} } @article{DigelMaggakisKelemenZerlinetal.2006, author = {Digel, Ilya and Maggakis-Kelemen, Christina and Zerlin, Kay and Linder, Peter}, title = {Body temperature-related structural transitions of monotremal and human hemoglobin}, series = {Biophysical Journal. 91 (2006), H. 8}, journal = {Biophysical Journal. 91 (2006), H. 8}, isbn = {1542-0086}, pages = {3014 -- 3021}, year = {2006}, language = {en} } @article{PoghossianWagnerSchoening2011, author = {Poghossian, Arshak and Wagner, Holger and Sch{\"o}ning, Michael Josef}, title = {Functional testing and characterisation of (bio-)chemical sensors on wafer level}, series = {Sensors and Actuators B: Chemical. 154 (2011), H. 2}, journal = {Sensors and Actuators B: Chemical. 154 (2011), H. 2}, publisher = {Elsevier}, address = {Amsterdam}, isbn = {1873-3077}, pages = {169 -- 173}, year = {2011}, language = {en} } @article{PoghossianBerndsenSchultzeetal.2001, author = {Poghossian, Arshak and Berndsen, L. and Schultze, J. W. and L{\"u}th, H. and Sch{\"o}ning, Michael Josef}, title = {„High order" hybrid sensor module based on an identical transducer principle}, series = {Chemical and biological sensors and analytical methods : proceedings of the international symposium / Sensor, Physical Electrochemistry, and Organic and Biological Electrochemistry Divisions. Ed.: M. Butler}, journal = {Chemical and biological sensors and analytical methods : proceedings of the international symposium / Sensor, Physical Electrochemistry, and Organic and Biological Electrochemistry Divisions. Ed.: M. Butler}, publisher = {Electrochemical Society}, address = {Pennington, NJ}, isbn = {1-56677-351-2}, pages = {143 -- 152}, year = {2001}, language = {en} } @article{PoghossianThustSchrothetal.2001, author = {Poghossian, Arshak and Thust, M. and Schroth, P. and Steffen, A. and L{\"u}th, H. and Sch{\"o}ning, Michael Josef}, title = {Penicillin detection by means of silicon-based field-effect structures}, series = {Sensors and Materials. 13 (2001), H. 4}, journal = {Sensors and Materials. 13 (2001), H. 4}, isbn = {0392-2510}, pages = {207 -- 223}, year = {2001}, language = {en} } @article{TranTrinhDaoetal.2022, author = {Tran, Ngoc Trinh and Trinh, Tu Luc and Dao, Ngoc Tien and Giap, Van Tan and Truong, Manh Khuyen and Dinh, Thuy Ha and Staat, Manfred}, title = {FEM shakedown analysis of structures under random strength with chance constrained programming}, series = {Vietnam Journal of Mechanics}, volume = {44}, journal = {Vietnam Journal of Mechanics}, number = {4}, publisher = {Vietnam Academy of Science and Technology (VAST)}, issn = {0866-7136}, doi = {10.15625/0866-7136/17943}, pages = {459 -- 473}, year = {2022}, abstract = {Direct methods, comprising limit and shakedown analysis, are a branch of computational mechanics. They play a significant role in mechanical and civil engineering design. The concept of direct methods aims to determine the ultimate load carrying capacity of structures beyond the elastic range. In practical problems, the direct methods lead to nonlinear convex optimization problems with a large number of variables and constraints. If strength and loading are random quantities, the shakedown analysis can be formulated as stochastic programming problem. In this paper, a method called chance constrained programming is presented, which is an effective method of stochastic programming to solve shakedown analysis problems under random conditions of strength. In this study, the loading is deterministic, and the strength is a normally or lognormally distributed variable.}, language = {en} } @article{BaeckerPoghossianAbouzaretal.2010, author = {B{\"a}cker, Matthias and Poghossian, Arshak and Abouzar, Maryam H. and Wenmackers, Sylvia and Janssens, Stoffel D. and Haenen, Ken and Wagner, Patrick and Sch{\"o}ning, Michael Josef}, title = {Capacitive field-effect (bio-)chemical sensors based on nanocrystalline diamond films}, series = {Diamond Electronics and Bioelectronics — Fundamentals to Applications III, edited by P. Bergonzo, [u.a.]}, journal = {Diamond Electronics and Bioelectronics — Fundamentals to Applications III, edited by P. Bergonzo, [u.a.]}, pages = {1 -- 6}, year = {2010}, language = {en} } @inproceedings{TranTranMatthiesetal.2016, author = {Tran, Ngoc Trinh and Tran, Thanh Ngoc and Matthies, H. G. and Stavroulakis, G. E. and Staat, Manfred}, title = {Shakedown analysis of plate bending analysis under stochastic uncertainty by chance constrained programming}, series = {ECCOMAS Congress 2016, VII European Congress on Computational Methods in Applied Sciences and Engineering. Crete Island, Greece, 5-10 June 2016}, booktitle = {ECCOMAS Congress 2016, VII European Congress on Computational Methods in Applied Sciences and Engineering. Crete Island, Greece, 5-10 June 2016}, editor = {Papadrakakis, M.}, pages = {13 S.}, year = {2016}, language = {en} } @article{ZerlinKasischkeDigeletal.2007, author = {Zerlin, Kay and Kasischke, Nicole and Digel, Ilya and Maggakis-Kelemen, Christina and Temiz Artmann, Ayseg{\"u}l and Porst, Dariusz and Kayser, Peter and Linder, Peter and Artmann, Gerhard}, title = {Structural transition temperature of hemoglobins correlates with species' body temperature}, series = {European Biophysics Journal. 37 (2007), H. 1}, journal = {European Biophysics Journal. 37 (2007), H. 1}, isbn = {1432-1017}, pages = {1 -- 10}, year = {2007}, language = {en} } @inproceedings{WeilPoghossianSchoeningetal.2012, author = {Weil, M. and Poghossian, Arshak and Sch{\"o}ning, Michael Josef and Cherstvy, A.}, title = {Electrical monitoring of layer-by-layer adsorption of oppositely charged macromolecules by means of capacitive field-effect devices}, isbn = {978-3-9813484-2-2}, doi = {10.5162/IMCS2012/P2.5.2}, pages = {1575 -- 1578}, year = {2012}, language = {en} } @article{LaackRefisch1989, author = {Laack, Walter van and Refisch, A.}, title = {Neuralgic amyotrophy of the lumbar area. Case Report / Refisch, A. ; Laack, W. van}, series = {Archives of Orthopaedic and Trauma Surgery. 108 (1989), H. 5}, journal = {Archives of Orthopaedic and Trauma Surgery. 108 (1989), H. 5}, isbn = {0936-8051}, pages = {329 -- 332}, year = {1989}, language = {en} } @article{Digel2011, author = {Digel, Ilya}, title = {Primary thermosensory events in cells}, series = {Transient receptor potential channels / Md. Shahidul Islam, ed.}, journal = {Transient receptor potential channels / Md. Shahidul Islam, ed.}, publisher = {Springer}, address = {Dordrecht [u.a.]}, isbn = {978-94-007-0264-6}, pages = {451 -- 468}, year = {2011}, language = {en} } @article{SchoeningNaetherAugeretal.2005, author = {Sch{\"o}ning, Michael Josef and N{\"a}ther, Niko and Auger, V. and Poghossian, Arshak and Koudelka-Hep, M.}, title = {Miniaturised flow-through cell with integrated capacitive EIS sensor fabricated at wafer level using Si and SU-8 technologies}, series = {Sensors and Actuators B. 108 (2005), H. 1-2}, journal = {Sensors and Actuators B. 108 (2005), H. 1-2}, isbn = {0925-4005}, pages = {986 -- 992}, year = {2005}, language = {en} } @article{PoghossianSchoening2021, author = {Poghossian, Arshak and Sch{\"o}ning, Michael Josef}, title = {Recent progress in silicon-based biologically sensitive field-effect devices}, series = {Current Opinion in Electrochemistry}, journal = {Current Opinion in Electrochemistry}, number = {Article number: 100811}, publisher = {Elsevier}, address = {Amsterdam}, issn = {2451-9103}, doi = {10.1016/j.coelec.2021.100811}, year = {2021}, abstract = {Biologically sensitive field-effect devices (BioFEDs) advantageously combine the electronic field-effect functionality with the (bio)chemical receptor's recognition ability for (bio)chemical sensing. In this review, basic and widely applied device concepts of silicon-based BioFEDs (ion-sensitive field-effect transistor, silicon nanowire transistor, electrolyte-insulator-semiconductor capacitor, light-addressable potentiometric sensor) are presented and recent progress (from 2019 to early 2021) is discussed. One of the main advantages of BioFEDs is the label-free sensing principle enabling to detect a large variety of biomolecules and bioparticles by their intrinsic charge. The review encompasses applications of BioFEDs for the label-free electrical detection of clinically relevant protein biomarkers, deoxyribonucleic acid molecules and viruses, enzyme-substrate reactions as well as recording of the cell acidification rate (as an indicator of cellular metabolism) and the extracellular potential.}, language = {en} } @article{PoghossianSchoeningSchrothetal.2001, author = {Poghossian, Arshak and Sch{\"o}ning, Michael Josef and Schroth, P. and Simonis, A. and L{\"u}th, H.}, title = {An ISFET-based penicillin sensor with high sensitivity, low detection limit and long lifetime}, series = {Sensors and Actuators B. 76 (2001), H. 1-3}, journal = {Sensors and Actuators B. 76 (2001), H. 1-3}, isbn = {0925-4005}, pages = {519 -- 526}, year = {2001}, language = {en} } @article{HuckSchiffelsHerreraetal.2013, author = {Huck, Christina and Schiffels, Johannes and Herrera, Cony N. and Schelden, Maximilian and Selmer, Thorsten and Poghossian, Arshak and Baumann, Marcus and Wagner, Patrick and Sch{\"o}ning, Michael Josef}, title = {Metabolic responses of Escherichia coli upon glucose pulses captured by a capacitive field-effect sensor}, series = {Physica Status Solidi (A)}, volume = {210}, journal = {Physica Status Solidi (A)}, number = {5}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {0031-8965}, doi = {10.1002/pssa.201200900}, pages = {926 -- 931}, year = {2013}, abstract = {Living cells are complex biological systems transforming metabolites taken up from the surrounding medium. Monitoring the responses of such cells to certain substrate concentrations is a challenging task and offers possibilities to gain insight into the vitality of a community influenced by the growth environment. Cell-based sensors represent a promising platform for monitoring the metabolic activity and thus, the "welfare" of relevant organisms. In the present study, metabolic responses of the model bacterium Escherichia coli in suspension, layered onto a capacitive field-effect structure, were examined to pulses of glucose in the concentration range between 0.05 and 2 mM. It was found that acidification of the surrounding medium takes place immediately after glucose addition and follows Michaelis-Menten kinetic behavior as a function of the glucose concentration. In future, the presented setup can, therefore, be used to study substrate specificities on the enzymatic level and may as well be used to perform investigations of more complex metabolic responses. Conclusions and perspectives highlighting this system are discussed.}, language = {en} } @inproceedings{WeldenSeverinsPoghossianetal.2022, author = {Welden, Melanie and Severins, Robin and Poghossian, Arshak and Wege, Christina and Siegert, Petra and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Studying the immobilization of acetoin reductase with Tobacco mosaic virus particles on capacitive field-effect sensors}, series = {2022 IEEE International Symposium on Olfaction and Electronic Nose (ISOEN)}, booktitle = {2022 IEEE International Symposium on Olfaction and Electronic Nose (ISOEN)}, publisher = {IEEE}, isbn = {978-1-6654-5860-3 (Online)}, doi = {10.1109/ISOEN54820.2022.9789657}, pages = {4 Seiten}, year = {2022}, abstract = {A capacitive electrolyte-insulator-semiconductor (EISCAP) biosensor modified with Tobacco mosaic virus (TMV) particles for the detection of acetoin is presented. The enzyme acetoin reductase (AR) was immobilized on the surface of the EISCAP using TMV particles as nanoscaffolds. The study focused on the optimization of the TMV-assisted AR immobilization on the Ta 2 O 5 -gate EISCAP surface. The TMV-assisted acetoin EISCAPs were electrochemically characterized by means of leakage-current, capacitance-voltage, and constant-capacitance measurements. The TMV-modified transducer surface was studied via scanning electron microscopy.}, language = {en} } @inproceedings{PoghossianBronderSchejaetal.2016, author = {Poghossian, Arshak and Bronder, Thomas and Scheja, S. and Wu, Chunsheng and Metzger-Boddien, C. and Keusgen, M. and Sch{\"o}ning, Michael Josef}, title = {Label-free Electrostatic Detection of DNA Amplification by PCR Using Capacitive Field-effect Devices}, series = {Procedia Engineering}, volume = {Vol. 168}, booktitle = {Procedia Engineering}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1877-7058}, doi = {10.1016/j.proeng.2016.11.512}, pages = {514 -- 517}, year = {2016}, abstract = {A capacitive field-effect EIS (electrolyte-insulator-semiconductor) sensor modified with a positively charged weak polyelectrolyte of poly(allylamine hydrochloride) (PAH)/single-stranded probe DNA (ssDNA) bilayer has been used for a label-free electrostatic detection of pathogen-specific DNA amplification via polymerase chain reaction (PCR). The sensor is able to distinguish between positive and negative PCR solutions, to detect the existence of target DNA amplicons in PCR samples and thus, can be used as tool for a quick verification of DNA amplification and the successful PCR process.}, language = {en} } @article{SiqueiraWernerBaeckeretal.2009, author = {Siqueira, Jose R. and Werner, Frederik and B{\"a}cker, Matthias and Poghossian, Arshak and Zucolotto, Valtencir and Oliveira, Osvaldo N. Jr. and Sch{\"o}ning, Michael Josef}, title = {Layer-by-Layer Assembly of Carbon Nanotubes Incorporated in Light-Addressable Potentiometric Sensors}, series = {Journal of Physical Chemistry C. 113 (2009), H. 33}, journal = {Journal of Physical Chemistry C. 113 (2009), H. 33}, publisher = {American Chemical Society}, address = {Washington, DC}, isbn = {1932-7455}, pages = {14765 -- 14770}, year = {2009}, language = {en} } @article{SchoeningBrinkmannRolkaetal.2005, author = {Sch{\"o}ning, Michael Josef and Brinkmann, D. and Rolka, David and Demuth, C. and Poghossian, Arshak}, title = {CIP (cleaning-in-place) suitable "non-glass" pH sensor based on a Ta2O5-gate EIS structure}, series = {Sensors and Actuators B: Chemical. 111-112 (2005)}, journal = {Sensors and Actuators B: Chemical. 111-112 (2005)}, isbn = {0925-4005}, pages = {423 -- 429}, year = {2005}, language = {en} } @article{TranStaat2013, author = {Tran, Thanh Ngoc and Staat, Manfred}, title = {An Edge-Based Smoothed Finite Element Method for Primal-Dual Shakedown Analysis of Structures Under Uncertainties}, series = {Limit State of Materials and Structures : Direct Methods 2. Saxc{\´e}, G{\´e}ry de (Hrsg.)}, journal = {Limit State of Materials and Structures : Direct Methods 2. Saxc{\´e}, G{\´e}ry de (Hrsg.)}, publisher = {Springer}, address = {Dordrecht}, isbn = {978-94-007-5424-9}, pages = {89 -- 102}, year = {2013}, language = {en} } @article{Digel2008, author = {Digel, Ilya}, title = {Controlling microbial adhesion : a surface engineering approach}, series = {Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.)}, journal = {Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.)}, publisher = {Springer}, address = {Berlin [u.a.]}, isbn = {978-3-540-75408-4}, pages = {601 -- 625}, year = {2008}, language = {en} } @article{PoghossianWernerBuniatyanetal.2017, author = {Poghossian, Arshak and Werner, Frederik and Buniatyan, V. V. and Wagner, Torsten and Miamoto, K. and Yoshinobu, T. and Sch{\"o}ning, Michael Josef}, title = {Towards addressability of light-addressable potentiometric sensors: Shunting effect of non-illuminated region and cross-talk}, series = {Sensor and Actuators B: Chemical}, journal = {Sensor and Actuators B: Chemical}, number = {244}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0925-4005}, doi = {10.1016/j.snb.2017.01.047}, pages = {1071 -- 1079}, year = {2017}, abstract = {The LAPS (light-addressable potentiometric sensor) platform is one of the most attractive approaches for chemical and biological sensing with many applications ranging from pH and ion/analyte concentration measurements up to cell metabolism detection and chemical imaging. However, although it is generally accepted that LAPS measurements are spatially resolved, the light-addressability feature of LAPS devices has not been discussed in detail so far. In this work, an extended electrical equivalent-circuit model of the LAPS has been presented, which takes into account possible cross-talk effects due to the capacitive coupling of the non-illuminated region. A shunting effect of the non-illuminated area on the measured photocurrent and addressability of LAPS devices has been studied. It has been shown, that the measured photocurrent will be determined not only by the local interfacial potential in the illuminated region but also by possible interfacial potential changes in the non-illuminated region, yielding cross-talk effects. These findings were supported by the experimental investigations of a penicillin-sensitive multi-spot LAPS and a metal-insulator-semiconductor LAPS as model systems.}, language = {en} } @article{HasanKeilStaatetal.2012, author = {Hasan, Istabrak and Keil, Ludger and Staat, Manfred and Wahl, Gerhard and Bourauel, Christoph}, title = {Determination of the frictional coefficient of the implant-antler interface : experimental approach}, series = {Biomedical Engineering / Biomedizinische Technik}, volume = {57}, journal = {Biomedical Engineering / Biomedizinische Technik}, number = {5}, publisher = {De Gruyter}, address = {Berlin}, issn = {1862-278X}, pages = {359 -- 363}, year = {2012}, abstract = {The similar bone structure of reindeer antler to human bone permits studying the osseointegration of dental implants in the jawbone. As the friction is one of the major factors that have a significant influence on the initial stability of immediately loaded dental implants, it is essential to define the frictional coefficient of the implant-antler interface. In this study, the kinetic frictional forces at the implant-antler interface were measured experimentally using an optomechanical setup and a stepping motor controller under different axial loads and sliding velocities. The corresponding mean values of the static and kinetic frictional coefficients were within the range of 0.5-0.7 and 0.3-0.5, respectively. An increase in the frictional forces with increasing applied axial loads was registered. The measurements showed an evidence of a decrease in the magnitude of the frictional coefficient with increasing sliding velocity. The results of this study provide a considerable assessment to clarify the suitable frictional coefficient to be used in the finite element contact analysis of antler specimens.}, language = {en} } @article{DemirciKurulganDemirciTrzewiketal.2009, author = {Demirci, Taylan and Kurulgan Demirci, Eylem and Trzewik, J{\"u}rgen and Linder, Peter and Digel, Ilya and Artmann, Gerhard and Sakizli, Meral and Temiz Artmann, Ayseg{\"u}l}, title = {Gene expression profile analysis of 3T3/NIH fibroblasts after one hour mechanical stress}, series = {IUBMB Life. 61 (2009), H. 3}, journal = {IUBMB Life. 61 (2009), H. 3}, publisher = {Wiley-VCH}, address = {Weinheim}, isbn = {1521-6543}, pages = {311 -- 312}, year = {2009}, language = {en} } @article{SchoeningPoghossian2008, author = {Sch{\"o}ning, Michael Josef and Poghossian, Arshak}, title = {Detection of charged macromolecules by means of field-effect devices (FEDs): possibilities and limitations}, series = {Electrochemical sensors, biosensors and their biomedical applications / ed. by Xueji Zhang ...}, journal = {Electrochemical sensors, biosensors and their biomedical applications / ed. by Xueji Zhang ...}, publisher = {Elsevier Acad. Press}, address = {Amsterdam}, isbn = {978-0-12-373738-0}, pages = {187 -- 212}, year = {2008}, language = {en} } @book{Laack2002, author = {Laack, Walter van}, title = {A better history of our world / Vol. 2. Life}, publisher = {van Laack}, address = {Aachen}, isbn = {978-3-8311-2597-5}, pages = {236 S.}, year = {2002}, language = {en} } @article{VoegeleJosyabhatlaBalletal.2023, author = {V{\"o}gele, Stefan and Josyabhatla, Vishnu Teja and Ball, Christopher and Rhoden, Imke and Grajewski, Matthias and R{\"u}bbelke, Dirk and Kuckshinrichs, Wilhelm}, title = {Robust assessment of energy scenarios from stakeholders' perspectives}, series = {Energy}, journal = {Energy}, number = {In Press, Article 128326}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1873-6785 (Online)}, doi = {10.1016/j.energy.2023.128326}, year = {2023}, abstract = {Using scenarios is vital in identifying and specifying measures for successfully transforming the energy system. Such transformations can be particularly challenging and require the support of a broader set of stakeholders. Otherwise, there will be opposition in the form of reluctance to adopt the necessary technologies. Usually, processes for considering stakeholders' perspectives are very time-consuming and costly. In particular, there are uncertainties about how to deal with modifications in the scenarios. In principle, new consulting processes will be required. In our study, we show how multi-criteria decision analysis can be used to analyze stakeholders' attitudes toward transition paths. Since stakeholders differ regarding their preferences and time horizons, we employ a multi-criteria decision analysis approach to identify which stakeholders will support or oppose a transition path. We provide a flexible template for analyzing stakeholder preferences toward transition paths. This flexibility comes from the fact that our multi-criteria decision aid-based approach does not involve intensive empirical work with stakeholders. Instead, it involves subjecting assumptions to robustness analysis, which can help identify options to influence stakeholders' attitudes toward transitions.}, language = {en} } @article{MolinnusBaeckerIkenetal.2015, author = {Molinnus, Denise and B{\"a}cker, Matthias and Iken, Heiko and Poghossian, Arshak and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Concept for a biomolecular logic chip with an integrated sensor and actuator function}, series = {Physica status solidi (a)}, volume = {212}, journal = {Physica status solidi (a)}, number = {6}, publisher = {Wiley}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.201431913}, pages = {1382 -- 1388}, year = {2015}, abstract = {A concept for a new generation of an integrated multi-functional biosensor/actuator system is developed, which is based on biomolecular logic principles. Such a system is expected to be able to detect multiple biochemical input signals simultaneously and in real-time and convert them into electrical output signals with logical operations such as OR, AND, etc. The system can be designed as a closed-loop drug release device triggered by an enzyme logic gate, while the release of the drug induced by the actuator at the required dosage and timing will be controlled by an additional drug sensor. Thus, the system could help to make an accurate and specific diagnosis. The presented concept is exemplarily demonstrated by using an enzyme logic gate based on a glucose/glucose oxidase system, a temperature-responsive hydrogel mimicking the actuator function and an insulin (drug) sensor. In this work, the results of functional testing of individual amperometric glucose and insulin sensors as well as an impedimetric sensor for the detection of the hydrogel swelling/shrinking are presented.}, language = {en} } @article{AyalaHarrisKleefeldetal.2023, author = {Ayala, Rafael Ceja and Harris, Isaac and Kleefeld, Andreas and Pallikarakis, Nikolaos}, title = {Analysis of the transmission eigenvalue problem with two conductivity parameters}, series = {Applicable Analysis}, journal = {Applicable Analysis}, publisher = {Taylor \& Francis}, issn = {0003-6811}, doi = {10.1080/00036811.2023.2181167}, pages = {37 Seiten}, year = {2023}, abstract = {In this paper, we provide an analytical study of the transmission eigenvalue problem with two conductivity parameters. We will assume that the underlying physical model is given by the scattering of a plane wave for an isotropic scatterer. In previous studies, this eigenvalue problem was analyzed with one conductive boundary parameter whereas we will consider the case of two parameters. We prove the existence and discreteness of the transmission eigenvalues as well as study the dependence on the physical parameters. We are able to prove monotonicity of the first transmission eigenvalue with respect to the parameters and consider the limiting procedure as the second boundary parameter vanishes. Lastly, we provide extensive numerical experiments to validate the theoretical work.}, language = {en} } @article{ChristiaensAbouzarPoghossianetal.2007, author = {Christiaens, P. and Abouzar, Maryam H. and Poghossian, Arshak and Wagner, Torsten and Bijnens, N. and Williams, O. A. and Daenen, M. and Haenen, K. and Douth{\´e}ret, O. and Haen, J. d´ and Mekhalif, Z. and Sch{\"o}ning, Michael Josef and Wagner, P.}, title = {pH sensitivity of nanocrystalline diamond films}, series = {Physica status solidi (A). 204 (2007), H. 9}, journal = {Physica status solidi (A). 204 (2007), H. 9}, isbn = {0031-8965}, pages = {2925 -- 2930}, year = {2007}, language = {en} } @article{WuPoghossianBronderetal.2016, author = {Wu, Chunsheng and Poghossian, Arshak and Bronder, Thomas and Sch{\"o}ning, Michael Josef}, title = {Sensing of double-stranded DNA molecules by their intrinsic molecular charge using the light-addressable potentiometric sensor}, series = {Sensors and Actuators B: Chemical}, journal = {Sensors and Actuators B: Chemical}, number = {229}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0925-4005}, doi = {10.1016/j.snb.2016.02.004}, pages = {506 -- 512}, year = {2016}, abstract = {A multi-spot light-addressable potentiometric sensor (LAPS), which belongs to the family of semiconductor field-effect devices, was applied for label-free detection of double-stranded deoxyribonucleic acid (dsDNA) molecules by their intrinsic molecular charge. To reduce the distance between the DNA charge and sensor surface and thus, to enhance the electrostatic coupling between the dsDNA molecules and the LAPS, the negatively charged dsDNA molecules were electrostatically adsorbed onto the gate surface of the LAPS covered with a positively charged weak polyelectrolyte layer of PAH (poly(allylamine hydrochloride)). The surface potential changes in each spot of the LAPS, induced by the layer-by-layer adsorption of a PAH/dsDNA bilayer, were recorded by means of photocurrent-voltage and constant-photocurrent measurements. In addition, the surface morphology of the gate surface before and after consecutive electrostatic adsorption of PAH and dsDNA layers was studied by atomic force microscopy measurements. Moreover, fluorescence microscopy was used to verify the successful adsorption of dsDNA molecules onto the PAH-modified LAPS surface. A high sensor signal of 25 mV was registered after adsorption of 10 nM dsDNA molecules. The lower detection limit is down to 0.1 nM dsDNA. The obtained results demonstrate that the PAH-modified LAPS device provides a convenient and rapid platform for the direct label-free electrical detection of in-solution hybridized dsDNA molecules.}, language = {en} } @article{SchusserBaeckerKrischeretal.2014, author = {Schusser, Sebastian and B{\"a}cker, Matthias and Krischer, M. and Wenzel, L. and Leinhos, Marcel and Poghossian, Arshak and Biselli, Manfred and Wagner, P. and Sch{\"o}ning, Michael Josef}, title = {Enzymatically catalyzed degradation of biodegradable polymers investigated by means of a semiconductor-based field-effect sensor}, series = {Procedia Engineering}, volume = {87}, journal = {Procedia Engineering}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1877-7058}, doi = {10.1016/j.proeng.2014.11.689}, pages = {1314 -- 1317}, year = {2014}, abstract = {A semiconductor field-effect device has been used for an enzymatically catalyzed degradation of biopolymers for the first time. This novel technique is capable to monitor the degradation process of multiple samples in situ and in real-time. As model system, the degradation of the biopolymer poly(D, L-lactic acid) has been monitored in the degradation medium containing the enzyme lipase from Rhizomucor miehei. The obtained results demonstrate the potential of capacitive field-effect sensors for degradation studies of biodegradable polymers.}, language = {en} } @article{StulpeHellwig1983, author = {Stulpe, Werner and Hellwig, K.-E.}, title = {A Formulation of Quantum Stochastic Processes and Some of its Properties. Hellwig, K.-E.; Stulpe, W.}, series = {Foundations of Physics. 13 (1983), H. 7}, journal = {Foundations of Physics. 13 (1983), H. 7}, isbn = {1572-9516}, pages = {673 -- 699}, year = {1983}, language = {en} } @article{Staat2013, author = {Staat, Manfred}, title = {Limit and shakedown analysis under uncertainty}, series = {International journal of computational methods : IJCM}, journal = {International journal of computational methods : IJCM}, publisher = {World Scientific Publishing}, address = {Singapore}, issn = {0219-8762}, pages = {Publ. online}, year = {2013}, language = {en} } @book{Laack2001, author = {Laack, Walter van}, title = {A better history of our world / Vol. 1. The universe}, publisher = {van Laack}, address = {Aachen}, isbn = {978-3-8311-1490-0}, pages = {188 S.}, year = {2001}, language = {en} } @article{PoghossianSchoening2014, author = {Poghossian, Arshak and Sch{\"o}ning, Michael Josef}, title = {Label-free sensing of biomolecules with field-effect devices for clinical applications}, series = {Electroanalysis}, volume = {26}, journal = {Electroanalysis}, number = {6}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1521-4109 (E-Journal); 1040-0397 (Print)}, doi = {10.1002/elan.201400073}, pages = {1197 -- 1213}, year = {2014}, abstract = {Among the variety of transducer concepts proposed for label-free detection of biomolecules, the semiconductor field-effect device (FED) is one of the most attractive platforms. As medical techniques continue to progress towards diagnostic and therapies based on biomarkers, the ability of FEDs for a label-free, fast and real-time detection of multiple pathogenic and physiologically relevant molecules with high specificity and sensitivity offers very promising prospects for their application in point-of-care and personalized medicine for an early diagnosis and treatment of diseases. The presented paper reviews recent advances and current trends in research and development of different FEDs for label-free, direct electrical detection of charged biomolecules by their intrinsic molecular charge. The authors are mainly focusing on the detection of the DNA hybridization event, antibody-antigen affinity reaction as well as clinically relevant biomolecules such as cardiac and cancer biomarkers.}, language = {en} } @incollection{FrotscherStaat2018, author = {Frotscher, Ralf and Staat, Manfred}, title = {Towards Patient-Specific Computational Modeling of hiPS-Derived Cardiomyocyte Function and Drug Action}, series = {Biological, Physical and Technical Basics of Cell Engineering}, booktitle = {Biological, Physical and Technical Basics of Cell Engineering}, editor = {Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l and Zhubanova, Azhar A. and Digel, Ilya}, publisher = {Springer}, address = {Singapore}, isbn = {978-981-10-7904-7}, doi = {10.1007/978-981-10-7904-7_10}, pages = {233 -- 250}, year = {2018}, abstract = {Human-induced pluripotent stem cell-derived cardiomyocytes (hiPS-CM) today are widely used for the investigation of normal electromechanical cardiac function, of cardiac medication and of mutations. Computational models are thus established that simulate the behavior of this kind of cells. This section first motivates the modeling of hiPS-CM and then presents and discusses several modeling approaches of microscopic and macroscopic constituents of human-induced pluripotent stem cell-derived and mature human cardiac tissue. The focus is led on the mapping of the computational results one can achieve with these models onto mature human cardiomyocyte models, the latter being the real matter of interest. Model adaptivity is the key feature that is discussed because it opens the way for modeling various biological effects like biological variability, medication, mutation and phenotypical expression. We compare the computational with experimental results with respect to normal cardiac function and with respect to inotropic and chronotropic drug effects. The section closes with a discussion on the status quo of the specificity of computational models and on what challenges have to be solved to reach patient-specificity.}, language = {en} } @inproceedings{TranStaat2012, author = {Tran, Thanh Ngoc and Staat, Manfred}, title = {A primal-dual shakedown analysis of 3D structures using the face-based smoothed finite element method}, series = {Proceedings European Congress on Computational Methods in Applied Sciences and Engineering (ECCOMAS 2012)}, booktitle = {Proceedings European Congress on Computational Methods in Applied Sciences and Engineering (ECCOMAS 2012)}, editor = {Eberhardsteiner, J.}, year = {2012}, language = {en} } @article{LeinhosSchusserBaeckeretal.2014, author = {Leinhos, Marcel and Schusser, Sebastian and B{\"a}cker, Matthias and Poghossian, Arshak and Sch{\"o}ning, Michael Josef}, title = {Micromachined multi-parameter sensor chip for the control of polymer-degradation medium}, series = {Physica Status Solidi (A) : special issue on engineering and functional interfaces}, volume = {211}, journal = {Physica Status Solidi (A) : special issue on engineering and functional interfaces}, number = {6}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1521-396X (E-Journal); 1862-6319 (E-Journal); 0031-8965 (Print); 1862-6300 (Print)}, doi = {10.1002/pssa.201330364}, pages = {1346 -- 1351}, year = {2014}, abstract = {It is well known that the degradation environment can strongly influence the biodegradability and kinetics of biodegradation processes of polymers. Therefore, besides the monitoring of the degradation process, it is also necessary to control the medium in which the degradation takes place. In this work, a micromachined multi-parameter sensor chip for the control of the polymer-degradation medium has been developed. The chip combines a capacitive field-effect pH sensor, a four-electrode electrolyte-conductivity sensor and a thin-film Pt-temperature sensor. The results of characterization of individual sensors are presented. In addition, the multi-parameter sensor chip together with an impedimetric polymer-degradation sensor was simultaneously characterized in degradation solutions with different pH and electrolyte conductivity. The obtained results demonstrate the feasibility of the multi-parameter sensor chip for the control of the polymer-degradation medium.}, language = {en} } @article{HuckPoghossianBaeckeretal.2014, author = {Huck, Christina and Poghossian, Arshak and B{\"a}cker, Matthias and Chaudhuri, S. and Zander, W. and Schubert, J. and Begoyan, V. K. and Buniatyan, V. V. and Wagner, P. and Sch{\"o}ning, Michael Josef}, title = {Capacitively coupled electrolyte-conductivity sensor based on high-k material of barium strontium titanate}, series = {Sensors and actuators. B: Chemical}, journal = {Sensors and actuators. B: Chemical}, number = {198}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1873-3077 (E-Journal); 0925-4005 (Print)}, doi = {10.1016/j.snb.2014.02.103}, pages = {102 -- 109}, year = {2014}, language = {en} } @article{PoghossianAbouzarAmbergeretal.2007, author = {Poghossian, Arshak and Abouzar, Maryam H. and Amberger, F. and Mayer, D. and Han, Y. and Ingebrandt, S. and Offenh{\"a}usser, A. and Sch{\"o}ning, Michael Josef}, title = {Field-effect sensors with charged macromolecules: Characterisation by capacitance-voltage, constant-capacitance, impedance spectroscopy and atomic-force microscopy methods}, series = {Biosensors and Bioelectronics. 22 (2007), H. 9-10}, journal = {Biosensors and Bioelectronics. 22 (2007), H. 9-10}, isbn = {0956-5663}, pages = {2100 -- 2107}, year = {2007}, language = {en} } @article{SchusserMenzelBaeckeretal.2013, author = {Schusser, Sebastian and Menzel, S. and B{\"a}cker, Matthias and Leinhos, Marcel and Poghossian, Arshak and Wagner, P. and Sch{\"o}ning, Michael Josef}, title = {Degradation of thin poly(lactic acid) films: characterization by capacitance-voltage, atomic force microscopy, scanning electron microscopy and contact-angle measurements}, series = {Electrochimica Acta}, volume = {Vol. 113}, journal = {Electrochimica Acta}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1873-3859 (E-Journal); 0013-4686 (Print)}, pages = {779 -- 784}, year = {2013}, language = {en} } @article{DigelDachwaldArtmannetal.2009, author = {Digel, Ilya and Dachwald, Bernd and Artmann, Gerhard and Linder, Peter and Funke, O.}, title = {A concept of a probe for particle analysis and life detection in icy environments}, pages = {1 -- 24}, year = {2009}, language = {en} } @article{BaeckerKochEibenetal.2017, author = {B{\"a}cker, Matthias and Koch, Claudia and Eiben, Sabine and Geiger, Fania and Eber, Fabian and Gliemann, Hartmut and Poghossian, Arshak and Wege, Christina and Sch{\"o}ning, Michael Josef}, title = {Tobacco mosaic virus as enzyme nanocarrier for electrochemical biosensors}, series = {Sensors and Actuators B: Chemical}, volume = {238}, journal = {Sensors and Actuators B: Chemical}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0925-4005}, doi = {10.1016/j.snb.2016.07.096}, pages = {716 -- 722}, year = {2017}, abstract = {The conjunction of (bio-)chemical recognition elements with nanoscale biological building blocks such as virus particles is considered as a very promising strategy for the creation of biohybrids opening novel opportunities for label-free biosensing. This work presents a new approach for the development of biosensors using tobacco mosaic virus (TMV) nanotubes or coat proteins (CPs) as enzyme nanocarriers. Sensor chips combining an array of Pt electrodes loaded with glucose oxidase (GOD)-modified TMV nanotubes or CP aggregates were used for amperometric detection of glucose as a model system for the first time. The presence of TMV nanotubes or CPs on the sensor surface allows binding of a high amount of precisely positioned enzymes without substantial loss of their activity, and may also ensure accessibility of their active centers for analyte molecules. Specific and efficient immobilization of streptavidin-conjugated GOD ([SA]-GOD) complexes on biotinylated TMV nanotubes or CPs was achieved via bioaffinity binding. These layouts were tested in parallel with glucose sensors with adsorptively immobilized [SA]-GOD, as well as [SA]-GOD crosslinked with glutardialdehyde, and came out to exhibit superior sensor performance. The achieved results underline a great potential of an integration of virus/biomolecule hybrids with electronic transducers for future applications in biosensorics and biochips.}, language = {en} } @article{BaeckerKramerHucketal.2014, author = {B{\"a}cker, Matthias and Kramer, F. and Huck, Christina and Poghossian, Arshak and Bratov, A. and Abramova, N. and Sch{\"o}ning, Michael Josef}, title = {Planar and 3D interdigitated electrodes for biosensing applications: The impact of a dielectric barrier on the sensor properties}, series = {Physica Status Solidi (A) - Applications and Materials Science}, volume = {211}, journal = {Physica Status Solidi (A) - Applications and Materials Science}, number = {6}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1521-396X (E-Journal); 1862-6319 (E-Journal); 0031-8965 (Print); 1862-6300 (Print)}, doi = {10.1002/pssa.201330416}, pages = {1357 -- 1363}, year = {2014}, abstract = {Planar and three-dimensional (3D) interdigitated electrodes (IDE) with electrode digits separated by an insulating barrier of different heights were electrochemically characterized and compared in terms of their sensing properties. Due to the impact of the surface resistance, both types of IDE structures display a non-linear behavior in low-ionic strength solutions. The experimental data were fitted to an electrical equivalent circuit and interpreted taking into account the surface-charge-governed properties. The effect of a charged polyelectrolyte layer electrostatically assembled onto the sensor surface on the surface resistance in solutions with different KCl concentration is studied. In case of the same electrode footprint, 3D-IDEs show a larger cell constant and a higher sensitivity to molecular adsorption than that of planar IDEs. The obtained results demonstrate the potential of 3D-IDEs as a new transducer structure for a direct label-free sensing of charged molecules.}, language = {en} } @article{PoghossianWeilBaeckeretal.2012, author = {Poghossian, Arshak and Weil, M. H. and B{\"a}cker, Matthias and Mayer, D. and Sch{\"o}ning, Michael Josef}, title = {Field-effect Devices Functionalised with Gold-Nanoparticle/Macromolecule Hybrids: New Opportunities for a Label-Free Biosensing}, series = {Procedia Engineering}, journal = {Procedia Engineering}, number = {47}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1877-7058}, doi = {10.1016/j.proeng.2012.09.136}, pages = {273 -- 276}, year = {2012}, abstract = {Field-effect capacitive electrolyte-insulator-semiconductor (EIS) sensors functionalised with citrate-capped gold nanoparticles (AuNP) have been used for the electrostatic detection of macromolecules by their intrinsic molecular charge. The EIS sensor detects the charge changes in the AuNP/macromolecule hybrids induced by the adsorption or binding events. A feasibility of the proposed detection scheme has been exemplary demonstrated by realising EIS sensors for the detection of poly-D-lysine molecules.}, language = {en} } @article{MoseleyHalamekKrameretal.2014, author = {Moseley, Fiona and Halamek, Jan and Kramer, Friederike and Poghossian, Arshak and Sch{\"o}ning, Michael Josef and Katz, Evgeny}, title = {An enzyme-based reversible CNOT logic gate realized in a flow system}, series = {Analyst}, volume = {139}, journal = {Analyst}, number = {8}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, issn = {1364-5528 (E-Journal) ; 0003-2654 (Print)}, doi = {10.1039/C4AN00133H}, pages = {1839 -- 1842}, year = {2014}, abstract = {An enzyme system organized in a flow device was used to mimic a reversible Controlled NOT (CNOT) gate with two input and two output signals. Reversible conversion of NAD⁺ and NADH cofactors was used to perform a XOR logic operation, while biocatalytic hydrolysis of p-nitrophenyl phosphate resulted in an Identity operation working in parallel. The first biomolecular realization of a CNOT gate is promising for integration into complex biomolecular networks and future biosensor/biomedical applications.}, language = {en} } @article{AbouzarWernerSchoeningetal.2011, author = {Abouzar, Maryam H. and Werner, Moritz and Sch{\"o}ning, Michael Josef and Poghossian, Arshak}, title = {Capacitance-voltage and impedance-spectroscopy characteristics of nanoplate EISOI capacitors}, series = {Physica status solidi (a) : applications and material science. 208 (2011), H. 6}, journal = {Physica status solidi (a) : applications and material science. 208 (2011), H. 6}, publisher = {Wiley-VCH}, address = {Berlin}, isbn = {1862-6319}, pages = {1327 -- 1332}, year = {2011}, language = {en} } @inproceedings{FrotscherRaatschenStaat2012, author = {Frotscher, Ralf and Raatschen, Hans-J{\"u}rgen and Staat, Manfred}, title = {Effectiveness of the edge-based smoothed finite element method applied to soft biological tissues}, series = {ESMC-2012 - 8th European Solid Mechanics Conference, Graz, Austria, July 9-13, 2012}, booktitle = {ESMC-2012 - 8th European Solid Mechanics Conference, Graz, Austria, July 9-13, 2012}, editor = {Holzapfel, Gerhard A.}, publisher = {Verlag d. Technischen Universit{\"a}t Graz}, address = {Graz}, isbn = {978-3-85125-223-1}, year = {2012}, language = {en} } @incollection{YoshinobuKrauseMiyamotoetal.2018, author = {Yoshinobu, Tatsuo and Krause, Steffi and Miyamoto, Ko-ichiro and Werner, Frederik and Poghossian, Arshak and Wagner, Torsten and Sch{\"o}ning, Michael Josef}, title = {(Bio-)chemical Sensing and Imaging by LAPS and SPIM}, series = {Label-free biosensing: advanced materials, devices and applications}, booktitle = {Label-free biosensing: advanced materials, devices and applications}, publisher = {Springer}, address = {Cham}, isbn = {978-3-319-75219-8}, pages = {103 -- 132}, year = {2018}, abstract = {The light-addressable potentiometric sensor (LAPS) and scanning photo-induced impedance microscopy (SPIM) are two closely related methods to visualise the distributions of chemical species and impedance, respectively, at the interface between the sensing surface and the sample solution. They both have the same field-effect structure based on a semiconductor, which allows spatially resolved and label-free measurement of chemical species and impedance in the form of a photocurrent signal generated by a scanning light beam. In this article, the principles and various operation modes of LAPS and SPIM, functionalisation of the sensing surface for measuring various species, LAPS-based chemical imaging and high-resolution sensors based on silicon-on-sapphire substrates are described and discussed, focusing on their technical details and prospective applications.}, language = {en} } @article{MiciliValterOflazetal.2013, author = {Micili, Serap C. and Valter, Markus and Oflaz, Hakan and Ozogul, Candan and Linder, Peter and F{\"o}ckler, Nicole and Artmann, Gerhard and Digel, Ilya and Temiz Artmann, Ayseg{\"u}l}, title = {Optical coherence tomography : a potential tool to predict premature rupture of fetal membranes}, series = {Proceedings of the Institution of Mechanical Engineers. Part H : Journal of engineering in medicine}, volume = {Vol. 227}, journal = {Proceedings of the Institution of Mechanical Engineers. Part H : Journal of engineering in medicine}, number = {No. 4}, publisher = {Sage}, address = {London}, issn = {0046-2039 (Print) ; 2041-3033 (E-Journal)}, pages = {393 -- 401}, year = {2013}, language = {en} } @inproceedings{TranTranMatthiesetal.2016, author = {Tran, Ngoc Trinh and Tran, Thanh Ngoc and Matthies, Hermann G. and Stavroulakis, Georgios Eleftherios and Staat, Manfred}, title = {FEM Shakedown of uncertain structures by chance constrained programming}, series = {PAMM Proceedings in Applied Mathematics and Mechanics}, volume = {16}, booktitle = {PAMM Proceedings in Applied Mathematics and Mechanics}, number = {1}, issn = {1617-7061}, doi = {10.1002/pamm.201610346}, pages = {715 -- 716}, year = {2016}, language = {en} } @book{Laack2007, author = {Laack, Walter van}, title = {To perceive the world with logic}, publisher = {van Laack}, address = {Aachen}, isbn = {978-3-936624-08-3}, pages = {340 S. : Ill., graph. Darst}, year = {2007}, language = {en} } @incollection{LehnertzBialonskiHorstmannetal.2010, author = {Lehnertz, Klaus and Bialonski, Stephan and Horstmann, Marie-Therese and Krug, Dieter and Rothkegel, Alexander and Staniek, Matth{\"a}us and Wagner, Tobias}, title = {Epilepsy}, series = {Reviews of Nonlinear Dynamics and Complexity, Volume 2}, booktitle = {Reviews of Nonlinear Dynamics and Complexity, Volume 2}, publisher = {Wiley-VCH}, isbn = {9783527628001}, doi = {10.1002/9783527628001.ch5}, pages = {159 -- 200}, year = {2010}, language = {en} } @article{SchoeningPoghossian2008, author = {Sch{\"o}ning, Michael Josef and Poghossian, Arshak}, title = {Silicon-based field-effect devices for (bio-)chemical sensing}, series = {International Conference on Advanced Semiconductor Devices and Microsystems, 2008. ASDAM 2008}, journal = {International Conference on Advanced Semiconductor Devices and Microsystems, 2008. ASDAM 2008}, address = {Smolenice, Slovakia}, isbn = {978-1-4244-2325-5}, pages = {31 -- 38}, year = {2008}, language = {en} } @inproceedings{MolinnusHardtKaeveretal.2017, author = {Molinnus, Denise and Hardt, Gabriel and K{\"a}ver, Larissa and Willenberg, Holger S. and Poghossian, Arshak and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Detection of Adrenaline Based on Bioelectrocatalytical System to Support Tumor Diagnostic Technology}, series = {MDPI Proceedings}, booktitle = {MDPI Proceedings}, doi = {10.3390/proceedings1040506}, pages = {4 Seiten}, year = {2017}, language = {en} } @article{PoghossianBaeckerMayeretal.2015, author = {Poghossian, Arshak and B{\"a}cker, Matthias and Mayer, Dirk and Sch{\"o}ning, Michael Josef}, title = {Gating capacitive field-effect sensors by the charge of nanoparticle/molecule hybrids}, series = {Nanoscale}, journal = {Nanoscale}, publisher = {Royal Society of Chemistry (RSC)}, address = {Cambridge}, issn = {2040-3372 (E-Journal); 2040-3364 (Print)}, doi = {10.1039/C4NR05987E}, pages = {1023 -- 1031}, year = {2015}, language = {en} } @article{GrottkeBraunschweigPhilippenetal.2010, author = {Grottke, O. and Braunschweig, T. and Philippen, B. and Gatzweiler, Karl-Heinz and Gronloh, N. and Staat, Manfred and Rossaint, R. and Tolba, R.}, title = {A New Model for Blunt Liver Injuries in the Swine}, series = {European Surgical Research. 44 (2010), H. 2}, journal = {European Surgical Research. 44 (2010), H. 2}, isbn = {1421-9921}, pages = {65 -- 73}, year = {2010}, language = {en} } @article{JungStaat2019, author = {Jung, Alexander and Staat, Manfred}, title = {Modeling and simulation of human induced pluripotent stem cell-derived cardiac tissue}, series = {GAMM - Mitteilungen der Gesellschaft f{\"u}r Angewandte Mathematik und Mechanik}, volume = {42}, journal = {GAMM - Mitteilungen der Gesellschaft f{\"u}r Angewandte Mathematik und Mechanik}, number = {4}, publisher = {Wiley}, address = {Weinheim}, issn = {1522-2608}, doi = {10.1002/gamm.201900002}, pages = {11 Seiten}, year = {2019}, language = {en} } @article{HuckPoghossianBaeckeretal.2014, author = {Huck, Christina and Poghossian, Arshak and B{\"a}cker, Matthias and Reisert, Steffen and Schubert, J. and Zander, W. and Begoyan, V. K. and Buniatyan, V. V. and Sch{\"o}ning, Michael Josef}, title = {Chemical sensors based on a high-k perovskite oxide of barium strontium titanate}, series = {Procedia Engineering}, volume = {87}, journal = {Procedia Engineering}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1877-7058}, doi = {10.1016/j.proeng.2014.11.258}, pages = {28 -- 31}, year = {2014}, abstract = {High-k perovskite oxide of barium strontium titanate (BST) represents a very attractive multi-functional transducer material for the development of (bio-)chemical sensors for liquids. In this work, BST films have been applied as a sensitive transducer material for a label-free detection of adsorbed charged macromolecules (positively charged polyelectrolytes) and concentration of hydrogen peroxide vapor as well as protection insulator layer for a contactless electrolyte-conductivity sensor. The experimental results of characterization of individual sensors are presented. Special emphasis is devoted towards the development of a capacitively-coupled contactless electrolyte-conductivity sensor.}, language = {en} } @phdthesis{Bhattarai2018, author = {Bhattarai, Aroj}, title = {Constitutive modeling of female pelvic floor dysfunctions and reconstructive surgeries using prosthetic mesh implants}, isbn = {978-3-9818074-8-6}, doi = {10.17185/duepublico/70340}, pages = {192 S.}, year = {2018}, language = {en} } @article{PoghossianBaadeEmonsetal.2001, author = {Poghossian, Arshak and Baade, A. and Emons, H. and Sch{\"o}ning, Michael Josef}, title = {Application of ISFET for pH measurements in rain droplets}, series = {Sensors and Actuators B. 76 (2001), H. 1-3}, journal = {Sensors and Actuators B. 76 (2001), H. 1-3}, isbn = {0925-4005}, pages = {634 -- 638}, year = {2001}, language = {en} } @article{KassabHanPoghossianetal.2004, author = {Kassab, T. and Han, Y. and Poghossian, Arshak and Ingebrandt, S. and Offenh{\"a}usser, A. and Sch{\"o}ning, Michael Josef}, title = {Detection of layerby-layer adsorbed polyelectrolytes by means of field-effect based capacitive EIS structures}, series = {Biomedizinische Technik. 49 (2004), H. 2}, journal = {Biomedizinische Technik. 49 (2004), H. 2}, isbn = {0932-4666}, pages = {1034 -- 1035}, year = {2004}, language = {en} } @article{BallVoegeleGrajewskietal.2021, author = {Ball, Christopher Stephen and V{\"o}gele, Stefan and Grajewski, Matthias and Kuckshinrichs, Wilhelm}, title = {E-mobility from a multi-actor point of view: Uncertainties and their impacts}, series = {Technological Forecasting and Social Change}, volume = {170}, journal = {Technological Forecasting and Social Change}, number = {Art. 120925}, publisher = {Elsevier}, address = {Amsterdam}, isbn = {0040-1625}, doi = {10.1016/j.techfore.2021.120925}, year = {2021}, language = {en} } @article{BuniatyanMatirosyanAbouzaretal.2009, author = {Buniatyan, V. V. and Matirosyan, N. W. and Abouzar, Maryam H. and Sch{\"o}ning, Michael Josef and Poghossian, Arshak and Schubert, J. and Khachatryan, V. R. and Soukiassyan, G. R.}, title = {(Ba,Sr)TiO3 based electrolyte-insulator-semiconductor pHsensors: comparitive study}, series = {Semiconductor micro- and nanoelectronics : Proceedings of the Seventh International Conference , Tsakhcadzor, Armenia July 3-5 2009}, journal = {Semiconductor micro- and nanoelectronics : Proceedings of the Seventh International Conference , Tsakhcadzor, Armenia July 3-5 2009}, pages = {71 -- 74}, year = {2009}, language = {en} } @article{PoghossianSchultzeSchoening2003, author = {Poghossian, Arshak and Schultze, J. W. and Sch{\"o}ning, Michael Josef}, title = {Multi-parameter detection of (bio-)chemical and physical quantities using an identical transducer principle}, series = {Sensors and Actuators B. 91 (2003), H. 1-3}, journal = {Sensors and Actuators B. 91 (2003), H. 1-3}, isbn = {0925-4005}, pages = {83 -- 91}, year = {2003}, language = {en} } @article{BronderPoghossianJessingetal.2019, author = {Bronder, Thomas and Poghossian, Arshak and Jessing, Max P. and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Surface regeneration and reusability of label-free DNA biosensors based on weak polyelectrolyte-modified capacitive field-effect structures}, series = {Biosensors and Bioelectronics}, volume = {126}, journal = {Biosensors and Bioelectronics}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0956-5663}, doi = {10.1016/j.bios.2018.11.019}, pages = {510 -- 517}, year = {2019}, language = {en} } @article{PoghossianMalzahnAbouzaretal.2011, author = {Poghossian, Arshak and Malzahn, K. and Abouzar, Maryam H. and Mehndiratta, P. and Katz, E. and Sch{\"o}ning, Michael Josef}, title = {Integration of biomolecular logic gates with field-effect transducers}, series = {Electrochimica Acta. 56 (2011), H. 26}, journal = {Electrochimica Acta. 56 (2011), H. 26}, publisher = {Elsevier}, address = {Amsterdam}, isbn = {0013-4686}, pages = {9661 -- 9665}, year = {2011}, language = {en} } @inproceedings{FrotscherStaat2015, author = {Frotscher, Ralf and Staat, Manfred}, title = {An electromechanical model for cardiac tissue constructs}, series = {Conference proceedings of the YIC GACM 2015 : 3rd ECCOMAS Young Investigators Conference and 6th GACM Colloquium on Computational Mechanics , Aachen, 20.07.2015 - 23.07.2015 / ed.: Stefanie Elgeti ; Jaan-Willem Simon}, booktitle = {Conference proceedings of the YIC GACM 2015 : 3rd ECCOMAS Young Investigators Conference and 6th GACM Colloquium on Computational Mechanics , Aachen, 20.07.2015 - 23.07.2015 / ed.: Stefanie Elgeti ; Jaan-Willem Simon}, publisher = {RWTH Aachen University}, address = {Aachen}, organization = {ECCOMAS Young Investigators Conference <3, 2015, Aachen>}, pages = {1 -- 4}, year = {2015}, language = {en} } @article{SiqueiraAbouzarBaeckeretal.2009, author = {Siqueira, Jos{\´e} R. Jr. and Abouzar, Maryam H. and B{\"a}cker, Matthias and Zucolotto, Valtencir and Poghossian, Arshak and Oliveira, Osvaldo N. Jr. and Sch{\"o}ning, Michael Josef}, title = {Carbon nanotubes in nanostructured films: Potential application as amperometric and potentiometric field-effect (bio-)chemical sensors}, series = {physica status solidi (a) . 206 (2009), H. 3}, journal = {physica status solidi (a) . 206 (2009), H. 3}, publisher = {Wiley}, address = {Weinheim}, isbn = {1862-6319}, pages = {462 -- 467}, year = {2009}, language = {en} } @article{WagnerMarisAckermannetal.2007, author = {Wagner, Torsten and Maris, Rob J. and Ackermann, Hans-Josef and Otto, Ralph and Beging, Stefan and Poghossian, Arshak and Sch{\"o}ning, Michael Josef}, title = {Handheld measurement device for field-effect sensor structures: Practical evaluation and limitations}, series = {Sensors and Actuators B: Chemical . 127 (2007), H. 1}, journal = {Sensors and Actuators B: Chemical . 127 (2007), H. 1}, isbn = {0925-4005}, pages = {217 -- 223}, year = {2007}, language = {en} } @article{AbouzarIngebrandtPoghossianetal.2009, author = {Abouzar, Maryam H. and Ingebrandt, S. and Poghossian, Arshak and Zhang, Y. and Vu, X. T. and Moritz, W. and Sch{\"o}ning, Michael Josef}, title = {Nanoplate field-effect capacitive (bio-)chemical sensor array based on SOI structure}, series = {Procedia Chemistry. 1 (2009), H. 1}, journal = {Procedia Chemistry. 1 (2009), H. 1}, isbn = {1876-6196}, pages = {670 -- 673}, year = {2009}, language = {en} } @article{SchusserPoghossianBaeckeretal.2015, author = {Schusser, Sebastian and Poghossian, Arshak and B{\"a}cker, Matthias and Krischer, M. and Leinhos, Marcel and Wagner, P. and Sch{\"o}ning, Michael Josef}, title = {An application of field-effect sensors for in-situ monitoring of degradation of biopolymers}, series = {Sensors and actuators B: Chemical}, volume = {207, Part B}, journal = {Sensors and actuators B: Chemical}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1873-3077 (E-Journal); 0925-4005 (Print)}, doi = {10.1016/j.snb.2014.10.058}, pages = {954 -- 959}, year = {2015}, abstract = {The characterization of the degradation kinetics of biodegradable polymers is mandatory with regard to their proper application. In the present work, polymer-modified electrolyte-insulator-semiconductor (PMEIS) field-effect sensors have been applied for in-situ monitoring of the pH-dependent degradation kinetics of the commercially available biopolymer poly(d,l-lactic acid) (PDLLA) in buffer solutions from pH 3 to pH 13. PDLLA films of 500 nm thickness were deposited on the surface of an Al-p-Si-SiO2-Ta2O5 structure from a polymer solution by means of spin-coating method. The PMEIS sensor is, in principle, capable to detect any changes in bulk, surface and interface properties of the polymer induced by degradation processes. A faster degradation has been observed for PDLLA films exposed to alkaline solutions (pH 9, pH 11 and pH 13).}, language = {en} } @article{ChristiaensAbouzarPoghossianetal.2007, author = {Christiaens, P. and Abouzar, Maryam H. and Poghossian, Arshak and Wagner, Torsten and Bijnens, N. and Williams, O. A. and Daenen, M. and Haenen, K. and Sch{\"o}ning, Michael Josef and Wagner, P.}, title = {Nanocrystalline diamond-based field-effect capacitive pH sensor}, series = {Transducers '07 Eurosensors XXI : digest of technical papers ; the14th International Conference on Solid-State Sensors, Actuators and Microsystems, June 10-14, 2007, Lyon, France / Gilles Delapierre (Ed.)}, journal = {Transducers '07 Eurosensors XXI : digest of technical papers ; the14th International Conference on Solid-State Sensors, Actuators and Microsystems, June 10-14, 2007, Lyon, France / Gilles Delapierre (Ed.)}, publisher = {IEEE}, address = {Piscataway}, isbn = {1-4244-0841-5}, pages = {1891 -- 1894}, year = {2007}, language = {en} } @article{SchoeningAbouzarIngebrandtetal.2006, author = {Sch{\"o}ning, Michael Josef and Abouzar, Maryam H. and Ingebrandt, Sven and Platen, Johannes and Offenh{\"a}usser, Andreas and Poghossian, Arshak}, title = {Towards label-free detection of charged macromolecules using field-effect-based structures : Scaling down from capacitive EIS sensor over ISFET to nano-scale devices}, series = {Nanostructured materials and hybrid composites for gas sensors and biomedical applications : symposium held April 18-20, 2006, San Francisco , California, U.S.A.}, journal = {Nanostructured materials and hybrid composites for gas sensors and biomedical applications : symposium held April 18-20, 2006, San Francisco , California, U.S.A.}, number = {paper 0915-R05-04}, editor = {Comini, Elisabetta}, isbn = {9781558998711}, pages = {89 -- 94}, year = {2006}, language = {en} } @article{AbouzarPedrazaSchoeningetal.2010, author = {Abouzar, Maryam H. and Pedraza, A. M. and Sch{\"o}ning, Michael Josef and Poghossian, Arshak}, title = {Label-free DNA hybridization and denaturation detection by means of field-effect nanoplate SOI capacitors functionalized with gold nanoparticles}, series = {Procedia Engineering. 5 (2010)}, journal = {Procedia Engineering. 5 (2010)}, isbn = {1877-7058}, pages = {918 -- 921}, year = {2010}, language = {en} } @article{DigelKurulganDemirciLinderetal.2007, author = {Digel, Ilya and Kurulgan Demirci, Eylem and Linder, Peter and Kayser, Peter}, title = {Decrease in extracellular collagen crosslinking after NMR magnetic field application in skin fibroblasts}, series = {Medical and Biological Engineering and Computing. 45 (2007), H. 1}, journal = {Medical and Biological Engineering and Computing. 45 (2007), H. 1}, isbn = {1741-0444}, pages = {91 -- 97}, year = {2007}, language = {en} } @article{SchusserPoghossianBaeckeretal.2012, author = {Schusser, Sebastian and Poghossian, Arshak and B{\"a}cker, Matthias and Leinhos, Marcel and Wagner, Patrick and Sch{\"o}ning, Michael Josef}, title = {Characterization of biodegradable polymers with capacitive field-effect sensors}, series = {Sensors and actuators B: Chemical}, volume = {187}, journal = {Sensors and actuators B: Chemical}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0925-4005}, doi = {10.1016/j.snb.2012.07.099}, pages = {2 -- 7}, year = {2012}, abstract = {In vitro studies of the degradation kinetic of biopolymers are essential for the design and optimization of implantable biomedical devices. In the presented work, a field-effect capacitive sensor has been applied for the real-time and in situ monitoring of degradation processes of biopolymers for the first time. The polymer-covered field-effect sensor is, in principle, capable to detect any changes in bulk, surface and interface properties of the polymer induced by degradation processes. The feasibility of this approach has been experimentally proven by using the commercially available biomedical polymer poly(D,L-lactic acid) (PDLLA) as a model system. PDLLA films of different thicknesses were deposited on the Ta₂O₅-gate surface of the field-effect structure from a polymer solution by means of spin-coating method. The polymer-modified field-effect sensors have been characterized by means of capacitance-voltage and impedance-spectroscopy method. The degradation of the PDLLA was accelerated by changing the degradation medium from neutral (pH 7.2) to alkaline (pH 9) condition, resulting in drastic changes in the capacitance and impedance spectra of the polymer-modified field-effect sensor.}, language = {en} } @article{SchusserKrischerMolinetal.2015, author = {Schusser, Sebastian and Krischer, M. and Molin, D. G. M. and Akker, N. M. S. van den and B{\"a}cker, Matthias and Poghossian, Arshak and Sch{\"o}ning, Michael Josef}, title = {Sensor System for in-situ and Real-time Monitoring of Polymer (bio) degradation}, series = {Procedia Engineering}, volume = {120}, journal = {Procedia Engineering}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1877-7058}, doi = {10.1016/j.proeng.2015.08.815}, pages = {948 -- 951}, year = {2015}, abstract = {A sensor system for investigating (bio)degradationprocesses of polymers is presented. The system utilizes semiconductor field-effect sensors and is capable of monitoring the degradation process in-situ and in real-time. The degradation of the polymer poly(d,l-lactic acid) is exemplarily monitored in solutions with different pH value, pH-buffer solution containing the model enzyme lipase from Rhizomucormiehei and cell-culture medium containing supernatants from stimulated and non-stimulated THP-1-derived macrophages mimicking activation of the immune system.}, language = {en} } @article{GasparyanPoghossianVitusevichetal.2009, author = {Gasparyan, F. V. and Poghossian, Arshak and Vitusevich, S. A. and Petrychuk, M. V. and Sydoruk, V. A. and Surmalyan, A. V. and Siqueira, J. R. and Oliveira, O. N. and Offenh{\"a}usser, A. and Sch{\"o}ning, Michael Josef}, title = {Low Frequency Noise In Electrolyte-Gate Field-Effect Devices Functionalized With Dendrimer/Carbon-Nanotube Multilayers}, series = {Noise and fluctuations : 20th International Conference on Noise and Fluctuations, ICNF 2009, Pisa, Italy, 14 - 19 June 2009 / ed. Massimo Macucci; Giovanni Basso}, journal = {Noise and fluctuations : 20th International Conference on Noise and Fluctuations, ICNF 2009, Pisa, Italy, 14 - 19 June 2009 / ed. Massimo Macucci; Giovanni Basso}, publisher = {American Inst. of Physics}, address = {Melville, NY}, isbn = {9780735406650}, pages = {133 -- 136}, year = {2009}, language = {en} } @article{BuniatyanAbouzarMartirosyanetal.2010, author = {Buniatyan, Vahe V. and Abouzar, Maryam H. and Martirosyan, Norayr W. and Schubert, J{\"u}rgen and Gevorgian, Spartak and Sch{\"o}ning, Michael Josef and Poghossian, Arshak}, title = {pH-sensitive properties of barium strontium titanate (BST) thin films prepared by pulsed laser deposition technique}, series = {Physica Status Solidi (A). 207 (2010), H. 4}, journal = {Physica Status Solidi (A). 207 (2010), H. 4}, isbn = {1862-6300}, pages = {824 -- 830}, year = {2010}, language = {en} } @article{StaatFioriniLensaetal.1997, author = {Staat, Manfred and Fiorini, G. L. and Lensa, W. von and Burgazzi, L.}, title = {Reliability Methods for Passive Safety Functions}, series = {Proceedings of the SMiRT 14 Post Conference Seminar No 18 on Passive Safety Features in Nuclear Installations}, journal = {Proceedings of the SMiRT 14 Post Conference Seminar No 18 on Passive Safety Features in Nuclear Installations}, address = {Pisa}, year = {1997}, language = {en} } @article{PoghossianAbouzarRazavietal.2009, author = {Poghossian, Arshak and Abouzar, Maryam H. and Razavi, A. and B{\"a}cker, Matthias and Bijnens, N. and Williams, O. A. and Haenen, K. and Moritz, W. and Wagner, P. and Sch{\"o}ning, Michael Josef}, title = {Nanocrystalline-diamond thin films with high pH and penicillin sensitivity prepared on a capacitive Si-SiO2 structure}, series = {Electrochimica Acta. 54 (2009), H. 25}, journal = {Electrochimica Acta. 54 (2009), H. 25}, isbn = {0013-4686}, pages = {5981 -- 5985}, year = {2009}, language = {en} } @article{JayaramanMummidisettyLoeschetal.2019, author = {Jayaraman, Chandrasekaran and Mummidisetty, Chaitanya Krishna and Loesch, Alexandra and Kaur, Sandi and Hoppe-Ludwig, Shenan and Staat, Manfred and Jayaraman, Arun}, title = {Postural and metabolic benefits of using a forearm support walker in older adults with impairments}, series = {Archives of Physical Medicine and Rehabilitation}, volume = {Volume 100}, journal = {Archives of Physical Medicine and Rehabilitation}, number = {Issue 4}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0003-9993}, doi = {10.1016/j.apmr.2018.10.001}, pages = {638 -- 647}, year = {2019}, language = {en} } @article{GunSchoeningAbouzaretal.2008, author = {Gun, Jenny and Sch{\"o}ning, Michael Josef and Abouzar, Maryam H. and Poghossian, Arshak and Katz, Evgeny}, title = {Field-Effect Nanoparticle-Based Glucose Sensor on a Chip: Amplification Effect of Coimmobilized Redox Species}, series = {Electroanalysis. 20 (2008), H. 16}, journal = {Electroanalysis. 20 (2008), H. 16}, isbn = {1521-4109}, pages = {1748 -- 1753}, year = {2008}, language = {en} } @article{PoghossianYoshinobuSimonisetal.2000, author = {Poghossian, Arshak and Yoshinobu, T. and Simonis, A. and Ecken, H. and L{\"u}th, H. and Sch{\"o}ning, Michael Josef}, title = {Penicillin detection by means of field-effect based sensors: EnFET, capacitive EIS sensor or LAPS?}, series = {Proceedings : Copenhagen, Denmark, 27 - 30 August 2000 / [ed.: R. de Reus ...]}, journal = {Proceedings : Copenhagen, Denmark, 27 - 30 August 2000 / [ed.: R. de Reus ...]}, publisher = {MIC, Mikroelektronik Centret}, address = {Lyngby, Denmark}, isbn = {87-89935-50-0}, pages = {27 -- 30}, year = {2000}, language = {en} } @article{HonarvarfardGamellaChannaveerappaetal.2017, author = {Honarvarfard, Elham and Gamella, Maria and Channaveerappa, Devika and Darie, Costel C. and Poghossian, Arshak and Sch{\"o}ning, Michael Josef and Katz, Evgeny}, title = {Electrochemically Stimulated Insulin Release from a Modified Graphene-functionalized Carbon Fiber Electrode}, series = {Electroanalysis}, volume = {29}, journal = {Electroanalysis}, number = {6}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1521-4109}, doi = {10.1002/elan.201700095}, pages = {1543 -- 1553}, year = {2017}, abstract = {A graphene-functionalized carbon fiber electrode was modified with adsorbed polyethylenimine to introduce amino functionalities and then with trigonelline and 4-carboxyphenylboronic acid covalently bound to the amino groups. The trigonelline species containing quarterized pyridine groups produced positive charge on the electrode surface regardless of the pH value, while the phenylboronic acid species were neutral below pH 8 and negatively charged above pH 9 (note that their pKa=8.4). The total charge on the monolayer-modified electrode was positive at the neutral pH and negative at pH > 9. Note that 4-carboxyphenylboronic acid was attached to the electrode surface in molar excess to trigonelline, thus allowing the negative charge to dominate on the electrode surface at basic pH. Negatively charged fluorescent dye-labeled insulin (insulin-FITC) was loaded on the modified electrode surface at pH 7.0 due to its electrostatic attraction to the positively charged interface. The local pH in close vicinity to the electrode surface was increased to ca. 9-10 due to consumption of H+ ions upon electrochemical reduction of oxygen proceeding at the potential of -1.0 V (vs. Ag/AgCl) applied on the modified electrode. The process resulted in recharging of the electrode surface to the negative value due to the formation of the negative charge on the phenylboronic acid groups, thus resulting in the electrostatic repulsion of insulin-FITC and stimulating its release from the electrode surface. The insulin release was characterized by fluorescence spectroscopy (using the FITC-labeled insulin), by electrochemical measurements on an iridium oxide, IrOx, electrode and by mass spectrometry. The graphene-functionalized carbon fiber electrode demonstrated significant advantages in the signal-stimulated insulin release comparing with the carbon fiber electrode without the graphene species.}, language = {en} } @article{MolinnusHardtKaeveretal.2018, author = {Molinnus, Denise and Hardt, G. and K{\"a}ver, L. and Willenberg, H.S. and Kr{\"o}ger, J.-C. and Poghossian, Arshak and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Chip-based biosensor for the detection of low adrenaline concentrations to support adrenal venous sampling}, series = {Sensor and Actuators B: Chemical}, volume = {272}, journal = {Sensor and Actuators B: Chemical}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0925-4005}, doi = {10.1016/j.snb.2018.05.136}, pages = {21 -- 27}, year = {2018}, abstract = {A chip-based amperometric biosensor referring on using the bioelectrocatalytical amplification principle for the detection of low adrenaline concentrations is presented. The adrenaline biosensor has been prepared by modification of a platinum thin-film electrode with an enzyme membrane containing the pyrroloquinoline quinone-dependent glucose dehydrogenase and glutaraldehyde. Measuring conditions such as temperature, pH value, and glucose concentration have been optimized to achieve a high sensitivity and a low detection limit of about 1 nM adrenaline measured in phosphate buffer at neutral pH value. The response of the biosensor to different catecholamines has also been proven. Long-term stability of the adrenaline biosensor has been studied over 10 days. In addition, the biosensor has been successfully applied for adrenaline detection in human blood plasma for future biomedical applications. Furthermore, preliminary experiments have been carried to detect the adrenaline-concentration difference measured in peripheral blood and adrenal venous blood, representing the adrenal vein sampling procedure of a physician.}, language = {en} } @article{PoghossianSchultzeSchoening2003, author = {Poghossian, Arshak and Schultze, J. W. and Sch{\"o}ning, Michael Josef}, title = {Application of a (bio-)chemical sensor (ISFET) for the detection of physical parameters in liquids}, series = {Electrochimica Acta. 48 (2003), H. 20-22}, journal = {Electrochimica Acta. 48 (2003), H. 20-22}, pages = {3289 -- 3297}, year = {2003}, language = {en} } @article{DuongNguyenTranetal.2015, author = {Duong, Minh Tuan and Nguyen, Nhu Huynh and Tran, Thanh Ngoc and Tolba, R. H. and Staat, Manfred}, title = {Influence of refrigerated storage on tensile mechanical properties of porcine liver and spleen}, series = {International biomechanics}, volume = {Vol. 2}, journal = {International biomechanics}, number = {Iss. 1}, publisher = {Taylor \& Francis}, address = {London}, issn = {2333-5432}, doi = {10.1080/23335432.2015.1049295}, pages = {79 -- 88}, year = {2015}, language = {en} } @article{StaatSponagelNguyen2010, author = {Staat, Manfred and Sponagel, Stefan and Nguyen, Nhu Huynh}, title = {Experiment and material model for soft tissue materials}, series = {Constitutive models for rubber VI : proceedings of the sixth European Conference on Constitutive Models for Rubber, Dresden, Germany, 7 - 10 September 2009 / eds. Gert Heinrich ...}, journal = {Constitutive models for rubber VI : proceedings of the sixth European Conference on Constitutive Models for Rubber, Dresden, Germany, 7 - 10 September 2009 / eds. Gert Heinrich ...}, publisher = {CRC Press}, address = {Boca Raton [u.a.]}, isbn = {978-0-415-56327-7}, pages = {465 -- 470}, year = {2010}, language = {en} } @article{BaeckerDellePoghossianetal.2011, author = {B{\"a}cker, Matthias and Delle, L. and Poghossian, Arshak and Biselli, Manfred and Zang, Werner and Wagner, P. and Sch{\"o}ning, Michael Josef}, title = {Electrochemical sensor array for bioprocess monitoring}, series = {Electrochimica Acta (2011)}, volume = {56}, journal = {Electrochimica Acta (2011)}, number = {26}, publisher = {Elsevier}, address = {Amsterdam}, pages = {9673 -- 9678}, year = {2011}, language = {en} } @article{SchoeningNaetherAugeretal.2004, author = {Sch{\"o}ning, Michael Josef and N{\"a}ther, Niko and Auger, V. and Poghossian, Arshak and Koudelka-Hep, M.}, title = {Miniaturized flow-through cell with integrated capacitive EIS sensors fabricated at wafer level using Si and Su-8 technologies}, series = {Technical digest of the 10th International Meeting on Chemical Sensors, July 11 - 14, 2004, Tsukuba, Japan / Japan Association of Chemical Sensors}, journal = {Technical digest of the 10th International Meeting on Chemical Sensors, July 11 - 14, 2004, Tsukuba, Japan / Japan Association of Chemical Sensors}, publisher = {Japan Association of Chemical Sensors}, address = {Fukuoka}, pages = {554 -- 555}, year = {2004}, language = {en} } @article{MourzinaMaiPoghossianetal.2003, author = {Mourzina, Y. and Mai, T. and Poghossian, Arshak and Ermolenko, Y. and Yoshinobu, T. and Vlasov, Y. and Iwasaki, H. and Sch{\"o}ning, Michael Josef}, title = {K+-selective field-effect sensors as transducers for bioelectronic applications}, series = {Electrochimica Acta. 48 (2003), H. 20-22}, journal = {Electrochimica Acta. 48 (2003), H. 20-22}, isbn = {0013-4686}, pages = {3333 -- 3339}, year = {2003}, language = {en} }