@article{RichterBraunsteinWinnardetal.2017, author = {Richter, Charlotte and Braunstein, Bjoern and Winnard, Andrew and Nasser, Mona and Weber, T.}, title = {Human Biomechanical and Cardiopulmonary Responses to Partial Gravity - A Systematic Review}, series = {Frontiers in physiology}, journal = {Frontiers in physiology}, number = {8, article 583}, doi = {10.3389/fphys.2017.00583}, pages = {22 Seiten}, year = {2017}, language = {en} } @inproceedings{HunkerJungGossmannetal.2019, author = {Hunker, Jan and Jung, Alexander and Goßmann, Matthias and Linder, Peter and Staat, Manfred}, title = {Development of a tool to analyze the conduction speed in microelectrode array measurements of cardiac tissue}, series = {3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH Aachen}, booktitle = {3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH Aachen}, editor = {Staat, Manfred and Erni, Daniel}, publisher = {Universit{\"a}t Duisburg-Essen}, address = {Duisburg}, organization = {MedTech Symposium}, isbn = {978-3-940402-22-6}, doi = {10.17185/duepublico/48750}, pages = {7 -- 8}, year = {2019}, abstract = {The discovery of human induced pluripotent stem cells reprogrammed from somatic cells [1] and their ability to differentiate into cardiomyocytes (hiPSC-CMs) has provided a robust platform for drug screening [2]. Drug screenings are essential in the development of new components, particularly for evaluating the potential of drugs to induce life-threatening pro-arrhythmias. Between 1988 and 2009, 14 drugs have been removed from the market for this reason [3]. The microelectrode array (MEA) technique is a robust tool for drug screening as it detects the field potentials (FPs) for the entire cell culture. Furthermore, the propagation of the field potential can be examined on an electrode basis. To analyze MEA measurements in detail, we have developed an open-source tool.}, language = {en} } @inproceedings{JungStaatMueller2016, author = {Jung, Alexander and Staat, Manfred and M{\"u}ller, Wolfram}, title = {Effect of wind on flight style optimisation in ski jumping}, series = {15th International Symposium on Computer Simulation in Biomechanics ; July 9th-11th 2015, Edinburgh, UK}, booktitle = {15th International Symposium on Computer Simulation in Biomechanics ; July 9th-11th 2015, Edinburgh, UK}, publisher = {The University of Edinburgh ; Loughborough University}, address = {Edinburgh}, pages = {53 -- 54}, year = {2016}, language = {en} } @article{Gaigall2019, author = {Gaigall, Daniel}, title = {On a new approach to the multi-sample goodness-of-fit problem}, series = {Communications in Statistics - Simulation and Computation}, volume = {53}, journal = {Communications in Statistics - Simulation and Computation}, number = {10}, publisher = {Taylor \& Francis}, address = {London}, issn = {1532-4141}, doi = {10.1080/03610918.2019.1618472}, pages = {2971 -- 2989}, year = {2019}, abstract = {Suppose we have k samples X₁,₁,…,X₁,ₙ₁,…,Xₖ,₁,…,Xₖ,ₙₖ with different sample sizes ₙ₁,…,ₙₖ and unknown underlying distribution functions F₁,…,Fₖ as observations plus k families of distribution functions {G₁(⋅,ϑ);ϑ∈Θ},…,{Gₖ(⋅,ϑ);ϑ∈Θ}, each indexed by elements ϑ from the same parameter set Θ, we consider the new goodness-of-fit problem whether or not (F₁,…,Fₖ) belongs to the parametric family {(G₁(⋅,ϑ),…,Gₖ(⋅,ϑ));ϑ∈Θ}. New test statistics are presented and a parametric bootstrap procedure for the approximation of the unknown null distributions is discussed. Under regularity assumptions, it is proved that the approximation works asymptotically, and the limiting distributions of the test statistics in the null hypothesis case are determined. Simulation studies investigate the quality of the new approach for small and moderate sample sizes. Applications to real-data sets illustrate how the idea can be used for verifying model assumptions.}, language = {en} } @unpublished{GriegerMehrkanoonBialonski2024, author = {Grieger, Niklas and Mehrkanoon, Siamak and Bialonski, Stephan}, title = {Preprint: Data-efficient sleep staging with synthetic time series pretraining}, series = {arXiv}, journal = {arXiv}, pages = {10 Seiten}, year = {2024}, abstract = {Analyzing electroencephalographic (EEG) time series can be challenging, especially with deep neural networks, due to the large variability among human subjects and often small datasets. To address these challenges, various strategies, such as self-supervised learning, have been suggested, but they typically rely on extensive empirical datasets. Inspired by recent advances in computer vision, we propose a pretraining task termed "frequency pretraining" to pretrain a neural network for sleep staging by predicting the frequency content of randomly generated synthetic time series. Our experiments demonstrate that our method surpasses fully supervised learning in scenarios with limited data and few subjects, and matches its performance in regimes with many subjects. Furthermore, our results underline the relevance of frequency information for sleep stage scoring, while also demonstrating that deep neural networks utilize information beyond frequencies to enhance sleep staging performance, which is consistent with previous research. We anticipate that our approach will be advantageous across a broad spectrum of applications where EEG data is limited or derived from a small number of subjects, including the domain of brain-computer interfaces.}, language = {en} } @article{Laack2013, author = {Laack, Walter van}, title = {Our world is well ordered in measurement and number : or why natural constants are as they are}, series = {American Journal of Humanities and Social Sciences (AHSS)}, volume = {1}, journal = {American Journal of Humanities and Social Sciences (AHSS)}, number = {4}, issn = {2329-079X}, doi = {10.11634/232907811301390}, pages = {219 -- 221}, year = {2013}, abstract = {All the important natural constants can be logically explained with and derived from the first four ordinal numbers, 1, 2, 3 and 4, its addition to ten and finally the standard values for obviously maximal feasibility Ω and the optimum in our world, the Golden Section (GS), i.e. the number sequences 273 and 618. They both are the first three numbers of irrational results by an arithmetical transformation of simple geometrical relationships by creating multiplicity out of singularity. Both of them show that the infinite is inherent in finiteness and explain in a simple way the smallest deviations and fluctuations between the physical AS-IS state and the obvious spiritual ideal behind: Wherever we look in this world, and especially in important key-positions, we regularly find these sequences. All of the above mentioned numbers so seem to be key players in our world, what can be demonstrated by the derivation of natural constants.}, language = {en} } @incollection{EngelmannShashaSlabu2021, author = {Engelmann, Ulrich M. and Shasha, Carolyn and Slabu, Ioana}, title = {Magnetic nanoparticle relaxation in biomedical application: focus on simulating nanoparticle heating}, series = {Magnetic nanoparticles in human health and medicine}, booktitle = {Magnetic nanoparticles in human health and medicine}, publisher = {Wiley-Blackwell}, address = {Hoboken, New Jeersey}, isbn = {978-1-119-75467-1}, pages = {327 -- 354}, year = {2021}, language = {en} } @article{BronderJessingPoghossianetal.2018, author = {Bronder, Thomas and Jessing, Max P. and Poghossian, Arshak and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Detection of PCR-Amplified Tuberculosis DNA Fragments with Polyelectrolyte-Modified Field-Effect Sensors}, series = {Analytical Chemistry}, volume = {90}, journal = {Analytical Chemistry}, number = {12}, publisher = {ACS Publications}, address = {Washington, DC}, issn = {0003-2700}, doi = {10.1021/acs.analchem.8b01807}, pages = {7747 -- 7753}, year = {2018}, abstract = {Field-effect-based electrolyte-insulator-semiconductor (EIS) sensors were modified with a bilayer of positively charged weak polyelectrolyte (poly(allylamine hydrochloride) (PAH)) and probe single-stranded DNA (ssDNA) and are used for the detection of complementary single-stranded target DNA (cDNA) in different test solutions. The sensing mechanism is based on the detection of the intrinsic molecular charge of target cDNA molecules after the hybridization event between cDNA and immobilized probe ssDNA. The test solutions contain synthetic cDNA oligonucleotides (with a sequence of tuberculosis mycobacteria genome) or PCR-amplified DNA (which origins from a template DNA strand that has been extracted from Mycobacterium avium paratuberculosis-spiked human sputum samples), respectively. Sensor responses up to 41 mV have been measured for the test solutions with DNA, while only small signals of ∼5 mV were detected for solutions without DNA. The lower detection limit of the EIS sensors was ∼0.3 nM, and the sensitivity was ∼7.2 mV/decade. Fluorescence experiments using SybrGreen I fluorescence dye support the electrochemical results.}, language = {en} } @misc{BurgethKleefeldNaegeletal.2020, author = {Burgeth, Bernhard and Kleefeld, Andreas and Naegel, Beno{\^i}t and Perret, Benjamin}, title = {Editorial — Special Issue: ISMM 2019}, series = {Mathematical Morphology - Theory and Applications}, volume = {4}, journal = {Mathematical Morphology - Theory and Applications}, number = {1}, publisher = {De Gruyter}, address = {Warschau}, issn = {2353-3390}, doi = {10.1515/mathm-2020-0200}, pages = {159 -- 161}, year = {2020}, abstract = {This editorial presents the Special Issue dedicated to the conference ISMM 2019 and summarizes the articles published in this Special Issue.}, language = {en} } @article{DitzhausGaigall2018, author = {Ditzhaus, Marc and Gaigall, Daniel}, title = {A consistent goodness-of-fit test for huge dimensional and functional data}, series = {Journal of Nonparametric Statistics}, volume = {30}, journal = {Journal of Nonparametric Statistics}, number = {4}, publisher = {Taylor \& Francis}, address = {Abingdon}, issn = {1029-0311}, doi = {10.1080/10485252.2018.1486402}, pages = {834 -- 859}, year = {2018}, abstract = {A nonparametric goodness-of-fit test for random variables with values in a separable Hilbert space is investigated. To verify the null hypothesis that the data come from a specific distribution, an integral type test based on a Cram{\´e}r-von-Mises statistic is suggested. The convergence in distribution of the test statistic under the null hypothesis is proved and the test's consistency is concluded. Moreover, properties under local alternatives are discussed. Applications are given for data of huge but finite dimension and for functional data in infinite dimensional spaces. A general approach enables the treatment of incomplete data. In simulation studies the test competes with alternative proposals.}, language = {en} } @article{GaigallGerstenbergTrinh2022, author = {Gaigall, Daniel and Gerstenberg, Julian and Trinh, Thi Thu Ha}, title = {Empirical process of concomitants for partly categorial data and applications in statistics}, series = {Bernoulli}, volume = {28}, journal = {Bernoulli}, number = {2}, publisher = {International Statistical Institute}, address = {Den Haag, NL}, issn = {1573-9759}, doi = {10.3150/21-BEJ1367}, pages = {803 -- 829}, year = {2022}, abstract = {On the basis of independent and identically distributed bivariate random vectors, where the components are categorial and continuous variables, respectively, the related concomitants, also called induced order statistic, are considered. The main theoretical result is a functional central limit theorem for the empirical process of the concomitants in a triangular array setting. A natural application is hypothesis testing. An independence test and a two-sample test are investigated in detail. The fairly general setting enables limit results under local alternatives and bootstrap samples. For the comparison with existing tests from the literature simulation studies are conducted. The empirical results obtained confirm the theoretical findings.}, language = {en} } @article{ArtmannGrebeHomrighausenetal.1988, author = {Artmann, Gerhard and Grebe, R. and Homrighausen, A. and Wolff, H. and Teitel, P. and Schmid-Sch{\"o}nbein, H.}, title = {Response of normal and diabetic erythrocytes to membrane deformation by chemical and mechanical forces. Artmann, Gerhard Michael; Grebe, R.; Homrighausen, A.; Wolff, H.; Teitel, P.; Schmid-Sch{\"o}nbein, H.}, series = {12. Jahrestagung der Gesellschaft f{\"u}r Mikrozirkulation}, journal = {12. Jahrestagung der Gesellschaft f{\"u}r Mikrozirkulation}, publisher = {Karger [u.a.]}, address = {Basel [u.a.]}, pages = {196 -- 200}, year = {1988}, language = {en} } @article{JungMuellerStaat2019, author = {Jung, Alexander and M{\"u}ller, Wolfram and Staat, Manfred}, title = {Optimization of the flight technique in ski jumping: the influence of wind}, number = {Early view}, publisher = {Elsevier}, address = {Amsterdam}, doi = {10.1016/j.jbiomech.2019.03.023}, year = {2019}, language = {en} } @inproceedings{AzarDigel2019, author = {Azar, Fouad and Digel, Ilya}, title = {Utilization of fluorescence spectroscopy and neural networks in clinical analysis}, series = {3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH Aachen}, booktitle = {3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH Aachen}, editor = {Staat, Manfred and Erni, Daniel}, publisher = {Universit{\"a}t Duisburg-Essen}, address = {Duisburg}, organization = {MedTech Symposium}, isbn = {978-3-940402-22-6}, doi = {10.17185/duepublico/48750}, pages = {40 -- 41}, year = {2019}, abstract = {Fluorescence topography of human urine in combination with learning algorithms can provide a variant pattern recognition method in analytical clinical chemistry and, eventually, diagnosis.}, language = {en} } @inproceedings{BornheimGriegerBialonski2021, author = {Bornheim, Tobias and Grieger, Niklas and Bialonski, Stephan}, title = {FHAC at GermEval 2021: Identifying German toxic, engaging, and fact-claiming comments with ensemble learning}, series = {Proceedings of the GermEval 2021 Workshop on the Identification of Toxic, Engaging, and Fact-Claiming Comments : 17th Conference on Natural Language Processing KONVENS 2021}, booktitle = {Proceedings of the GermEval 2021 Workshop on the Identification of Toxic, Engaging, and Fact-Claiming Comments : 17th Conference on Natural Language Processing KONVENS 2021}, publisher = {Heinrich Heine University}, address = {D{\"u}sseldorf}, doi = {10.48415/2021/fhw5-x128}, pages = {105 -- 111}, year = {2021}, language = {en} } @inproceedings{RamanJungHorvathetal.2019, author = {Raman, Aravind Hariharan and Jung, Alexander and Horv{\´a}th, Andr{\´a}s and Becker, Nadine and Staat, Manfred}, title = {Modification of a computer model of human stem cell-derived cardiomyocyte electrophysiology based on Patch-Clamp measurements}, series = {3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH Aachen}, booktitle = {3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH Aachen}, editor = {Staat, Manfred and Erni, Daniel}, publisher = {Universit{\"a}t Duisburg-Essen}, address = {Duisburg}, organization = {MedTech Symposium}, isbn = {978-3-940402-22-6}, doi = {10.17185/duepublico/48750}, pages = {10 -- 11}, year = {2019}, abstract = {Human induced pluripotent stem cells (hiPSCs) have shown to be promising in disease studies and drug screenings [1]. Cardiomyocytes derived from hiPSCs have been extensively investigated using patch-clamping and optical methods to compare their electromechanical behaviour relative to fully matured adult cells. Mathematical models can be used for translating findings on hiPSCCMs to adult cells [2] or to better understand the mechanisms of various ion channels when a drug is applied [3,4]. Paci et al. (2013) [3] developed the first model of hiPSC-CMs, which they later refined based on new data [3]. The model is based on iCells® (Fujifilm Cellular Dynamics, Inc. (FCDI), Madison WI, USA) but major differences among several cell lines and even within a single cell line have been found and motivate an approach for creating sample-specific models. We have developed an optimisation algorithm that parameterises the conductances (in S/F=Siemens/Farad) of the latest Paci et al. model (2018) [5] using current-voltage data obtained in individual patch-clamp experiments derived from an automated patch clamp system (Patchliner, Nanion Technologies GmbH, Munich).}, language = {en} } @article{JildehOberlaenderKirchneretal.2018, author = {Jildeh, Zaid B. and Oberl{\"a}nder, Jan and Kirchner, Patrick and Keusgen, Michael and Wagner, Patrick H. and Sch{\"o}ning, Michael Josef}, title = {Experimental and Numerical Analyzes of a Sensor Based on Interdigitated Electrodes for Studying Microbiological Alterations}, series = {physica status solidi (a): applications and materials science}, volume = {215}, journal = {physica status solidi (a): applications and materials science}, number = {15}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.201700920}, pages = {Artikel 1700920}, year = {2018}, abstract = {In this work, a cell-based biosensor to evaluate the sterilization efficacy of hydrogen peroxide vapor sterilization processes is characterized. The transducer of the biosensor is based on interdigitated gold electrodes fabricated on an inert glass substrate. Impedance spectroscopy is applied to evaluate the sensor behavior and the alteration of test microorganisms due to the sterilization process. These alterations are related to changes in relative permittivity and electrical conductivity of the bacterial spores. Sensor measurements are conducted with and without bacterial spores (Bacillus atrophaeus), as well as after an industrial sterilization protocol. Equivalent two-dimensional numerical models based on finite element method of the periodic finger structures of the interdigitated gold electrodes are designed and validated using COMSOL® Multiphysics software by the application of known dielectric properties. The validated models are used to compute the electrical properties at different sensor states (blank, loaded with spores, and after sterilization). As a final result, we will derive and tabulate the frequency-dependent electrical parameters of the spore layer using a novel model that combines experimental data with numerical optimization techniques.}, language = {en} } @article{DitzhausGaigall2022, author = {Ditzhaus, Marc and Gaigall, Daniel}, title = {Testing marginal homogeneity in Hilbert spaces with applications to stock market returns}, series = {Test}, volume = {2022}, journal = {Test}, number = {31}, publisher = {Springer}, issn = {1863-8260}, doi = {10.1007/s11749-022-00802-5}, pages = {749 -- 770}, year = {2022}, abstract = {This paper considers a paired data framework and discusses the question of marginal homogeneity of bivariate high-dimensional or functional data. The related testing problem can be endowed into a more general setting for paired random variables taking values in a general Hilbert space. To address this problem, a Cram{\´e}r-von-Mises type test statistic is applied and a bootstrap procedure is suggested to obtain critical values and finally a consistent test. The desired properties of a bootstrap test can be derived that are asymptotic exactness under the null hypothesis and consistency under alternatives. Simulations show the quality of the test in the finite sample case. A possible application is the comparison of two possibly dependent stock market returns based on functional data. The approach is demonstrated based on historical data for different stock market indices.}, language = {en} } @incollection{PieronekKleefeld2019, author = {Pieronek, Lukas and Kleefeld, Andreas}, title = {The Method of Fundamental Solutions for Computing Interior Transmission Eigenvalues of Inhomogeneous Media}, series = {Integral Methods in Science and Engineering: Analytic Treatment and Numerical Approximations}, booktitle = {Integral Methods in Science and Engineering: Analytic Treatment and Numerical Approximations}, editor = {Constanda, Christian and Harris, Paul}, publisher = {Birkh{\"a}user}, address = {Cham}, isbn = {978-3-030-16077-7}, doi = {10.1007/978-3-030-16077-7_28}, pages = {353 -- 365}, year = {2019}, abstract = {The method of fundamental solutions is applied to the approximate computation of interior transmission eigenvalues for a special class of inhomogeneous media in two dimensions. We give a short approximation analysis accompanied with numerical results that clearly prove practical convenience of our alternative approach.}, language = {en} } @article{KleefeldPieronek2020, author = {Kleefeld, Andreas and Pieronek, J.}, title = {Elastic transmission eigenvalues and their computation via the method of fundamental solutions}, series = {Applicable Analysis}, volume = {100}, journal = {Applicable Analysis}, number = {16}, publisher = {Taylore \& Francis}, address = {London}, issn = {1563-504X}, doi = {10.1080/00036811.2020.1721473}, pages = {3445 -- 3462}, year = {2020}, abstract = {A stabilized version of the fundamental solution method to catch ill-conditioning effects is investigated with focus on the computation of complex-valued elastic interior transmission eigenvalues in two dimensions for homogeneous and isotropic media. Its algorithm can be implemented very shortly and adopts to many similar partial differential equation-based eigenproblems as long as the underlying fundamental solution function can be easily generated. We develop a corroborative approximation analysis which also implicates new basic results for transmission eigenfunctions and present some numerical examples which together prove successful feasibility of our eigenvalue recovery approach.}, language = {en} } @inproceedings{BayerHeschelerArtmannetal.2019, author = {Bayer, Robin and Hescheler, J{\"u}rgen and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l}, title = {Treating arterial hypertension in a cell culture well}, series = {3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH AachenW}, booktitle = {3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH AachenW}, editor = {Staat, Manfred and Erni, Daniel}, publisher = {Universit{\"a}t Duisburg-Essen}, address = {Duisburg}, organization = {MedTech Symposium}, isbn = {978-3-940402-22-6}, doi = {10.17185/duepublico/48750}, pages = {5 -- 6}, year = {2019}, abstract = {Hypertension describes the pathological increase of blood pressure, which is most commonly associated with the increase of vascular wall stiffness [1]. Referring to the "Deutsche Bluthochdruck Liga" this pathology shows a growing trend in our aging society. In order to find novel pharmacological and probably personalized treatments, we want to present a functional approach to study biomechanical properties of a human aortic vascular model. In this method review we will give an overview of recent studies which were carried out with the CellDrum technology [2] and underline the added value to already existing standard procedures known from the field of physiology. Herein described CellDrum technology is a system to measure functional mechanical properties of cell monolayers and thin tissue constructs in-vitro. Additionally, the CellDrum enables to elucidate the mechanical response of cells to pharmacological drugs, toxins and vasoactive agents. Due to its highly flexible polymer support, cells can also be mechanically stimulated by steady and cyclic biaxial stretching.}, language = {en} } @inproceedings{SuryoputriGhaderiLinderetal.2017, author = {Suryoputri, Nathania and Ghaderi, Aydin and Linder, Peter and Kotliar, Konstantin and G{\"o}ttler, Jens and Sorg, Christian and Grimmer, Timo}, title = {Does hemodynamic response function change in Alzheimer disease?}, series = {2nd YRA MedTech Symposium 2017 : June 8th - 9th / 2017 / Hochschule Ruhr-West}, booktitle = {2nd YRA MedTech Symposium 2017 : June 8th - 9th / 2017 / Hochschule Ruhr-West}, editor = {Erni, Daniel and Fischerauer, Alice and Himmel, J{\"o}rg and Seeger, Thomas and Thelen, Klaus}, publisher = {Universit{\"a}t Duisburg-Essen}, address = {Duisburg}, organization = {MedTech Symposium}, isbn = {978-3-9814801-9-1}, doi = {10.17185/duepublico/43984}, pages = {92}, year = {2017}, language = {en} } @article{HorbachDuongStaat2017, author = {Horbach, Andreas and Duong, Minh Tuan and Staat, Manfred}, title = {Modelling of compressible and orthotropic surgical mesh implants based on optical deformation measurement}, series = {Journal of the mechanical behavior of biomedical materials}, volume = {74}, journal = {Journal of the mechanical behavior of biomedical materials}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1751-6161}, doi = {10.1016/j.jmbbm.2017.06.012}, pages = {400 -- 410}, year = {2017}, language = {en} } @article{RichterBraunsteinStaeudleetal.2021, author = {Richter, Charlotte and Braunstein, Bjoern and St{\"a}udle, Benjamin and Attias, Julia and Suess, Alexander and Weber, Tobias and Mileva, Katja N. and Rittweger, Joern and Green, David A. and Albracht, Kirsten}, title = {Gastrocnemius medialis contractile behavior is preserved during 30\% body weight supported gait training}, series = {Frontiers in Sports and Active Living}, volume = {2021}, journal = {Frontiers in Sports and Active Living}, number = {2}, publisher = {Frontiers}, address = {Lausanne}, issn = {2624-9367}, doi = {10.3389/fspor.2020.614559}, pages = {Artikel 614559}, year = {2021}, abstract = {Rehabilitative body weight supported gait training aims at restoring walking function as a key element in activities of daily living. Studies demonstrated reductions in muscle and joint forces, while kinematic gait patterns appear to be preserved with up to 30\% weight support. However, the influence of body weight support on muscle architecture, with respect to fascicle and series elastic element behavior is unknown, despite this having potential clinical implications for gait retraining. Eight males (31.9 ± 4.7 years) walked at 75\% of the speed at which they typically transition to running, with 0\% and 30\% body weight support on a lower-body positive pressure treadmill. Gastrocnemius medialis fascicle lengths and pennation angles were measured via ultrasonography. Additionally, joint kinematics were analyzed to determine gastrocnemius medialis muscle-tendon unit lengths, consisting of the muscle's contractile and series elastic elements. Series elastic element length was assessed using a muscle-tendon unit model. Depending on whether data were normally distributed, a paired t-test or Wilcoxon signed rank test was performed to determine if body weight supported walking had any effects on joint kinematics and fascicle-series elastic element behavior. Walking with 30\% body weight support had no statistically significant effect on joint kinematics and peak series elastic element length. Furthermore, at the time when peak series elastic element length was achieved, and on average across the entire stance phase, muscle-tendon unit length, fascicle length, pennation angle, and fascicle velocity were unchanged with respect to body weight support. In accordance with unchanged gait kinematics, preservation of fascicle-series elastic element behavior was observed during walking with 30\% body weight support, which suggests transferability of gait patterns to subsequent unsupported walking.}, language = {en} } @inproceedings{BlumAlbannaBenninghausetal.2019, author = {Blum, Yannik and Albanna, Walid and Benninghaus, Anne and Kotliar, Konstantin}, title = {Vasomotion in retinal vessels of patients presenting post hemorrhagic hydrocephalus following subarachnoid hemorrhage}, series = {3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH Aachen}, booktitle = {3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH Aachen}, editor = {Staat, Manfred and Erni, Daniel}, publisher = {Universit{\"a}t Duisburg-Essen}, address = {Duisburg}, organization = {MedTech Symposium}, isbn = {978-3-940402-22-6}, doi = {10.17185/duepublico/48750}, pages = {38 -- 39}, year = {2019}, abstract = {Clearance of blood components and fluid drainage play a crucial role in subarachnoid hemorrhage (SAH) and post hemorrhagic hydrocephalus (PHH). With the involvement of interstitial fluid (ISF) and cerebrospinal fluid (CSF), two pathways for the clearance of fluid and solutes in the brain are proposed. Starting at the level of capillaries, flow of ISF follows along the basement membranes in the walls of cerebral arteries out of the parenchyma to drain into the lymphatics and CSF [1]-[3]. Conversely, it is shown that CSF enters the parenchyma between glial and pial basement membranes of penetrating arteries [4]-[6]. Nevertheless, the involved structures and the contribution of either flow pathway to fluid balance between the subarachnoid space and interstitial space remains controversial. Low frequency oscillations in vascular tone are referred to as vasomotion and corresponding vasomotion waves are modeled as the driving force for flow of ISF out of the parenchyma [7]. Retinal vessel analysis (RVA) allows non-invasive measurement of retinal vessel vasomotion with respect to diameter changes [8]. Thus, the aim of the study is to investigate vasomotion in RVA signals of SAH and PHH patients.}, language = {en} } @article{DuongNguyenStaat2015, author = {Duong, Minh Tuan and Nguyen, Nhu Huynh and Staat, Manfred}, title = {Physical response of hyperelastic models for composite materials and soft tissues}, series = {Asia pacific journal on computational engineering}, volume = {2}, journal = {Asia pacific journal on computational engineering}, number = {3 (December 2015)}, issn = {2196-1166}, doi = {10.1186/s40540-015-0015-x}, pages = {1 -- 18}, year = {2015}, language = {en} } @article{MolinnusPoghossianKeusgenetal.2017, author = {Molinnus, Denise and Poghossian, Arshak and Keusgen, Michael and Katz, Evgeny and Sch{\"o}ning, Michael Josef}, title = {Coupling of Biomolecular Logic Gates with Electronic Transducers: From Single Enzyme Logic Gates to Sense/Act/Treat Chips}, series = {Electroanalysis}, volume = {29}, journal = {Electroanalysis}, number = {8}, publisher = {Wiley}, address = {Weinheim}, issn = {1521-4109}, doi = {10.1002/elan.201700208}, pages = {1840 -- 1849}, year = {2017}, abstract = {The integration of biomolecular logic principles with electronic transducers allows designing novel digital biosensors with direct electrical output, logically triggered drug-release, and closed-loop sense/act/treat systems. This opens new opportunities for advanced personalized medicine in the context of theranostics. In the present work, we will discuss selected examples of recent developments in the field of interfacing enzyme logic gates with electrodes and semiconductor field-effect devices. Special attention is given to an enzyme OR/Reset logic gate based on a capacitive field-effect electrolyte-insulator-semiconductor sensor modified with a multi-enzyme membrane. Further examples are a digital adrenaline biosensor based on an AND logic gate with binary YES/NO output and an integrated closed-loop sense/act/treat system comprising an amperometric glucose sensor, a hydrogel actuator, and an insulin (drug) sensor.}, language = {en} } @incollection{SchoeningWagnerPoghossianetal.2018, author = {Sch{\"o}ning, Michael Josef and Wagner, Torsten and Poghossian, Arshak and Miyamoto, K.I. and Werner, C.F. and Krause, S. and Yoshinobu, T.}, title = {Light-addressable potentiometric sensors for (bio-)chemical sensing and imaging}, series = {Encyclopedia of Interfacial Chemistry: Surface Science and Electrochemistry. Vol. 7}, booktitle = {Encyclopedia of Interfacial Chemistry: Surface Science and Electrochemistry. Vol. 7}, publisher = {Elsevier}, address = {Amsterdam}, isbn = {9780128097397}, pages = {295 -- 308}, year = {2018}, language = {en} } @article{PoghossianYoshinobuSimonisetal.2001, author = {Poghossian, Arshak and Yoshinobu, Tatsuo and Simonis, A. and Ecken, H. and L{\"u}th, Hans and Sch{\"o}ning, Michael Josef}, title = {Penicillin detection by means of field-effect based sensors: EnFET, capacitive EIS sensor or LAPS?}, series = {Sensors and Actuators B. 78 (2001), H. 1-3}, journal = {Sensors and Actuators B. 78 (2001), H. 1-3}, isbn = {0925-4005}, pages = {237 -- 242}, year = {2001}, language = {en} } @article{PoghossianSchoening2007, author = {Poghossian, Arshak and Sch{\"o}ning, Michael Josef}, title = {Chemical and biological field-effect sensors for liquids - a status report}, series = {Handbook of biosensors and biochips / ed. Robert S. Marks ... Bd. 1}, journal = {Handbook of biosensors and biochips / ed. Robert S. Marks ... Bd. 1}, publisher = {Wiley}, address = {Chichester}, isbn = {978-0-470-01905-4}, pages = {395 -- 412}, year = {2007}, language = {en} } @article{StaatHeitzer1999, author = {Staat, Manfred and Heitzer, M.}, title = {FEM-computation of load carrying capacity of highly loaded passive components by direct methods. Heitzer, M. ; Staat, M.}, series = {Nuclear Engineering and Design. 193 (1999), H. 3}, journal = {Nuclear Engineering and Design. 193 (1999), H. 3}, isbn = {0029-5493}, pages = {349 -- 358}, year = {1999}, language = {en} } @article{PoghossianWeilCherstvyetal.2013, author = {Poghossian, Arshak and Weil, M. and Cherstvy, A. G. and Sch{\"o}ning, Michael Josef}, title = {Electrical monitoring of polyelectrolyte multilayer formation by means of capacitive field-effect devices}, series = {Analytical and bioanalytical chemistry}, volume = {405}, journal = {Analytical and bioanalytical chemistry}, number = {20}, publisher = {Springer}, address = {Berlin}, issn = {1432-1130 ; 1618-2642}, doi = {10.1007/s00216-013-6951-9}, pages = {6425 -- 6436}, year = {2013}, abstract = {The semiconductor field-effect platform represents a powerful tool for detecting the adsorption and binding of charged macromolecules with direct electrical readout. In this work, a capacitive electrolyte-insulator-semiconductor (EIS) field-effect sensor consisting of an Al-p-Si-SiO2 structure has been applied for real-time in situ electrical monitoring of the layer-by-layer formation of polyelectrolyte (PE) multilayers (PEM). The PEMs were deposited directly onto the SiO2 surface without any precursor layer or drying procedures. Anionic poly(sodium 4-styrene sulfonate) and cationic weak polyelectrolyte poly(allylamine hydrochloride) have been chosen as a model system. The effect of the ionic strength of the solution, polyelectrolyte concentration, number and polarity of the PE layers on the characteristics of the PEM-modified EIS sensors have been studied by means of capacitance-voltage and constant-capacitance methods. In addition, the thickness, surface morphology, roughness and wettabilityof the PE mono- and multilayers have been characterised by ellipsometry, atomic force microscopy and water contact-angle methods, respectively. To explain potential oscillations on the gate surface and signal behaviour of the capacitive field-effect EIS sensor modified with a PEM, a simplified electrostatic model that takes into account the reduced electrostatic screening of PE charges by mobile ions within the PEM has been proposed and discussed.}, language = {en} } @article{SchoeningPoghossian2002, author = {Sch{\"o}ning, Michael Josef and Poghossian, Arshak}, title = {Recent advances in biologically sensitive field-effect transistors (BioFETs)}, series = {Analyst. 127 (2002)}, journal = {Analyst. 127 (2002)}, isbn = {0003-2654}, pages = {1137 -- 1151}, year = {2002}, language = {en} } @inproceedings{WuBronderPoghossianetal.2014, author = {Wu, Chunsheng and Bronder, Thomas and Poghossian, Arshak and Sch{\"o}ning, Michael Josef}, title = {DNA-hybridization detection using light-addressable potentiometric sensor modified with gold layer}, series = {Sensoren und Messsysteme 2014 ; Beitr{\"a}ge der 17. GMA/ITG-Fachtagung vom 3. bis 4. Juni 2014 in N{\"u}rnberg. (ITG-Fachbericht ; 250)}, booktitle = {Sensoren und Messsysteme 2014 ; Beitr{\"a}ge der 17. GMA/ITG-Fachtagung vom 3. bis 4. Juni 2014 in N{\"u}rnberg. (ITG-Fachbericht ; 250)}, publisher = {VDE-Verl.}, address = {D{\"u}sseldorf}, organization = {VDI/VDE-Gesellschaft Mess- und Automatisierungstechnik}, isbn = {978-3-8007-3622-5}, pages = {1 -- 4}, year = {2014}, language = {en} } @inproceedings{HuckPoghossianBuniatyanetal.2014, author = {Huck, Christina and Poghossian, Arshak and Buniatyan, V. and Sch{\"o}ning, Michael Josef}, title = {Multi-parameter detection for supporting monitoring and control of biogas processes in agriculture}, series = {Sensoren und Messsysteme 2014 ; Beitr{\"a}ge der 17. GMA/ITG-Fachtagung vom 3. bis 4. Juni 2014 in N{\"u}rnberg. (ITG-Fachbericht ; 250)}, booktitle = {Sensoren und Messsysteme 2014 ; Beitr{\"a}ge der 17. GMA/ITG-Fachtagung vom 3. bis 4. Juni 2014 in N{\"u}rnberg. (ITG-Fachbericht ; 250)}, publisher = {VDE-Verl.}, address = {Berlin}, organization = {VDI/VDE-Gesellschaft Mess- und Automatisierungstechnik}, isbn = {978-3-8007-3622-5}, pages = {1 -- 5}, year = {2014}, language = {en} } @incollection{SchoeningPoghossianGluecketal.2014, author = {Sch{\"o}ning, Michael Josef and Poghossian, Arshak and Gl{\"u}ck, Olaf and Thust, Marion}, title = {Electrochemical methods for the determination of chemical variables in aqueous media}, series = {Measurement, instrumentation, and sensors handbook / ed. by John G. Webster [u.a.] Vol. 2 : Electromagnetic, optical, radiation, chemical, and biomedical measurement}, booktitle = {Measurement, instrumentation, and sensors handbook / ed. by John G. Webster [u.a.] Vol. 2 : Electromagnetic, optical, radiation, chemical, and biomedical measurement}, publisher = {CRC Pr.}, address = {Boca Raton, Fla.}, isbn = {978-1-4398-4891-3}, pages = {55-1 -- 55-54}, year = {2014}, language = {en} } @article{SchwabedalSippelBrandtetal.2018, author = {Schwabedal, Justus T. C. and Sippel, Daniel and Brandt, Moritz D. and Bialonski, Stephan}, title = {Automated Classification of Sleep Stages and EEG Artifacts in Mice with Deep Learning}, doi = {10.48550/arXiv.1809.08443}, year = {2018}, abstract = {Sleep scoring is a necessary and time-consuming task in sleep studies. In animal models (such as mice) or in humans, automating this tedious process promises to facilitate long-term studies and to promote sleep biology as a data-driven f ield. We introduce a deep neural network model that is able to predict different states of consciousness (Wake, Non-REM, REM) in mice from EEG and EMG recordings with excellent scoring results for out-of-sample data. Predictions are made on epochs of 4 seconds length, and epochs are classified as artifactfree or not. The model architecture draws on recent advances in deep learning and in convolutional neural networks research. In contrast to previous approaches towards automated sleep scoring, our model does not rely on manually defined features of the data but learns predictive features automatically. We expect deep learning models like ours to become widely applied in different fields, automating many repetitive cognitive tasks that were previously difficult to tackle.}, language = {en} } @article{MolinnusBaeckerSiegertetal.2015, author = {Molinnus, Denise and B{\"a}cker, Matthias and Siegert, Petra and Willenberg, H. and Poghossian, Arshak and Keusgen, M. and Sch{\"o}ning, Michael Josef}, title = {Detection of Adrenaline Based on Substrate Recycling Amplification}, series = {Procedia Engineering}, volume = {120}, journal = {Procedia Engineering}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1877-7058}, doi = {10.1016/j.proeng.2015.08.708}, pages = {540 -- 543}, year = {2015}, abstract = {An amperometric enzyme biosensor has been applied for the detection of adrenaline. The adrenaline biosensor has been prepared by modification of an oxygen electrode with the enzyme laccase that operates at a broad pH range between pH 3.5 to pH 8. The enzyme molecules were immobilized via cross-linking with glutaraldehyde. The sensitivity of the developed adrenaline biosensor in different pH buffer solutions has been studied.}, language = {en} } @book{Laack2000, author = {Laack, Walter van}, title = {Nobody ever dies! / 1. ed.}, publisher = {van Laack}, address = {Aachen}, isbn = {978-3-936624-03-8}, pages = {272 S.}, year = {2000}, language = {en} } @incollection{BhattaraiStaat2018, author = {Bhattarai, Aroj and Staat, Manfred}, title = {Mechanics of soft tissue reactions to textile mesh implants}, series = {Biological, Physical and Technical Basics of Cell Engineering}, booktitle = {Biological, Physical and Technical Basics of Cell Engineering}, editor = {Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l and Zhubanova, Azhar A. and Digel, Ilya}, publisher = {Springer}, address = {Singapore}, isbn = {978-981-10-7904-7}, doi = {10.1007/978-981-10-7904-7_11}, pages = {251 -- 275}, year = {2018}, abstract = {For pelvic floor disorders that cannot be treated with non-surgical procedures, minimally invasive surgery has become a more frequent and safer repair procedure. More than 20 million prosthetic meshes are implanted each year worldwide. The simple selection of a single synthetic mesh construction for any level and type of pelvic floor dysfunctions without adopting the design to specific requirements increase the risks for mesh related complications. Adverse events are closely related to chronic foreign body reaction, with enhanced formation of scar tissue around the surgical meshes, manifested as pain, mesh erosion in adjacent structures (with organ tissue cut), mesh shrinkage, mesh rejection and eventually recurrence. Such events, especially scar formation depend on effective porosity of the mesh, which decreases discontinuously at a critical stretch when pore areas decrease making the surgical reconstruction ineffective that further augments the re-operation costs. The extent of fibrotic reaction is increased with higher amount of foreign body material, larger surface, small pore size or with inadequate textile elasticity. Standardized studies of different meshes are essential to evaluate influencing factors for the failure and success of the reconstruction. Measurements of elasticity and tensile strength have to consider the mesh anisotropy as result of the textile structure. An appropriate mesh then should show some integration with limited scar reaction and preserved pores that are filled with local fat tissue. This chapter reviews various tissue reactions to different monofilament mesh implants that are used for incontinence and hernia repairs and study their mechanical behavior. This helps to predict the functional and biological outcomes after tissue reinforcement with meshes and permits further optimization of the meshes for the specific indications to improve the success of the surgical treatment.}, language = {en} } @article{Stulpe2009, author = {Stulpe, Werner}, title = {Self-Adjoint Operator}, series = {Compendium of Quantum Physics : concepts, experiments, history and philosophy / Daniel Greenberger ... ed.}, journal = {Compendium of Quantum Physics : concepts, experiments, history and philosophy / Daniel Greenberger ... ed.}, publisher = {Springer}, address = {Berlin}, isbn = {978-3-540-70622-9}, pages = {692 -- 697}, year = {2009}, language = {en} } @article{Stulpe2009, author = {Stulpe, Werner}, title = {Unitary Operator}, series = {Compendium of Quantum Physics : concepts, experiments, history and philosophy / Daniel Greenberger ... ed.}, journal = {Compendium of Quantum Physics : concepts, experiments, history and philosophy / Daniel Greenberger ... ed.}, publisher = {Springer}, address = {Berlin}, isbn = {978-3-540-70622-9}, pages = {807 -- 809}, year = {2009}, language = {en} } @article{Stulpe2009, author = {Stulpe, Werner}, title = {Projection}, series = {Compendium of Quantum Physics : concepts, experiments, history and philosophy / Daniel Greenberger ... ed.}, journal = {Compendium of Quantum Physics : concepts, experiments, history and philosophy / Daniel Greenberger ... ed.}, publisher = {Springer}, address = {Berlin}, isbn = {978-3-540-70622-9}, pages = {497 -- 499}, year = {2009}, language = {en} } @article{AbouzarPoghossianCherstvyetal.2012, author = {Abouzar, Maryam H. and Poghossian, Arshak and Cherstvy, Andrey G. and Pedraza, Angela M. and Ingebrandt, Sven and Sch{\"o}ning, Michael Josef}, title = {Label-free electrical detection of DNA by means of field-effect nanoplate capacitors: Experiments and modeling}, series = {Physica Status Solidi (a)}, volume = {209}, journal = {Physica Status Solidi (a)}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.201100710}, pages = {925 -- 934}, year = {2012}, abstract = {Label-free electrical detection of consecutive deoxyribonucleic acid (DNA) hybridization/denaturation by means of an array of individually addressable field-effect-based nanoplate silicon-on-insulator (SOI) capacitors modified with gold nanoparticles (Au-NP) is investigated. The proposed device detects charge changes on Au-NP/DNA hybrids induced by the hybridization or denaturation event. DNA hybridization was performed in a high ionic-strength solution to provide a high hybridization efficiency. On the other hand, to reduce the screening of the DNA charge by counter ions and to achieve a high sensitivity, the sensor signal induced by the hybridization and denaturation events was measured in a low ionic-strength solution. High sensor signals of about 120, 90, and 80 mV were registered after the DNA hybridization, denaturation, and re-hybridization events, respectively. Fluorescence microscopy has been applied as reference method to verify the DNA immobilization, hybridization, and denaturation processes. An electrostatic charge-plane model for potential changes at the gate surface of a nanoplate field-effect sensor induced by the DNA hybridization has been developed taking into account both the Debye length and the distance of the DNA charge from the gate surface.}, language = {en} } @article{Laack2014, author = {Laack, Walter van}, title = {Therefore Fermat is right}, series = {American journal of humanities and social sciences : AJHSS}, volume = {2}, journal = {American journal of humanities and social sciences : AJHSS}, number = {2}, issn = {2329-079X (E-Journal); 2329-0781 (Print)}, pages = {117 -- 120}, year = {2014}, abstract = {It was Fernat's idea to investigate how many numbers would fulfill the equation according to the Pythagorean Theorem if the exponent were increased to random, e.g. to a3 + b3 = c3. His question became therefore: are there two whole numbers the cubes of which add up to the volume of the cube of a third whole number? He posed this same question, of course, for all kinds of higher exponents, so that the equation could be generalized: is there an integral solution for the equation an + bn = cn, if the exponent n is higher than 2? Although in 1993, the English mathematician Andrew Wiles was able to produce an arithmetical proof for Fermat's famous theorem, I will show that there is a simple logical explanation which is also pragmatic and plausible and what is the result of a fundamental alternative idea how our world seems to be constructed.}, language = {en} } @article{Stulpe2019, author = {Stulpe, Werner}, title = {Aspects of the Quantum-Classical Connection Based on Statistical Maps}, series = {Foundations of Physics}, volume = {49}, journal = {Foundations of Physics}, number = {6}, publisher = {Springer}, address = {Berlin}, doi = {10.1007/s10701-019-00269-9}, pages = {677 -- 692}, year = {2019}, language = {en} } @article{Stulpe2009, author = {Stulpe, Werner}, title = {Operator}, series = {Compendium of Quantum Physics : concepts, experiments, history and philosophy / Daniel Greenberger ... ed.}, journal = {Compendium of Quantum Physics : concepts, experiments, history and philosophy / Daniel Greenberger ... ed.}, publisher = {Springer}, address = {Berlin}, isbn = {978-3-540-70622-9}, pages = {440 -- 444}, year = {2009}, language = {en} } @article{StulpeBuschHellwig1993, author = {Stulpe, Werner and Busch, P. and Hellwig, K.-E.}, title = {Classical Representations of Finite-Dimensional Quantum Mechanics. Busch, P.; Hellwig, K.-E.; Stulpe, W.}, series = {International Journal of Theoretical Physics. 32 (1993), H. 3}, journal = {International Journal of Theoretical Physics. 32 (1993), H. 3}, isbn = {1572-9575}, pages = {399 -- 405}, year = {1993}, language = {en} } @article{PoghossianKraemerAbouzaretal.2009, author = {Poghossian, Arshak and Kr{\"a}mer, Melina and Abouzar, Maryam H. and Pita, Marcos and Katz, Evgeny and Sch{\"o}ning, Michael Josef}, title = {Interfacing of biocomputing systems with silicon chips: Enzyme logic gates based on field-effect devices}, series = {Procedia Chemistry. 1 (2009), H. 1}, journal = {Procedia Chemistry. 1 (2009), H. 1}, publisher = {Elsevier}, address = {Amsterdam}, isbn = {1876-6196}, pages = {682 -- 685}, year = {2009}, language = {en} } @incollection{SchoeningPoghossianGluecketal.2014, author = {Sch{\"o}ning, Michael Josef and Poghossian, Arshak and Gl{\"u}ck, Olaf and Thust, Marion}, title = {Electrochemical composition measurement}, series = {Measurement, instrumentation, and sensors handbook: electromagnetic, optical, radiation, chemical, and biomedical measuremen}, booktitle = {Measurement, instrumentation, and sensors handbook: electromagnetic, optical, radiation, chemical, and biomedical measuremen}, edition = {2nd ed.}, publisher = {CRC Pr.}, address = {Boca Raton, Fa.}, isbn = {978-1-4398-4891-3}, pages = {55-1 -- 55-54}, year = {2014}, language = {en} } @article{PoghossianGeisslerSchoening2019, author = {Poghossian, Arshak and Geissler, Hanno and Sch{\"o}ning, Michael Josef}, title = {Rapid methods and sensors for milk quality monitoring and spoilage detection}, series = {Biosensors and Bioelectronics}, volume = {140}, journal = {Biosensors and Bioelectronics}, number = {Article 111272}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0956-5663}, doi = {10.1016/j.bios.2019.04.040}, year = {2019}, language = {en} } @article{Laack2014, author = {Laack, Walter van}, title = {Nature is much smarter than expected: the Genetic Code is not degenerate}, series = {American journal of humanities and social sciences}, volume = {Vol. 2}, journal = {American journal of humanities and social sciences}, number = {No. 1}, issn = {2329-0781 (Print) ; 2329-079X (Online)}, pages = {10 -- 12}, year = {2014}, abstract = {In any books about genetics it can still today be read that our genetic code is called "degenerate" because it is still believed that 43 = 64 triplets encode the 20 essential amino acids. Indeed we have to assume the inverse law, what means that 34 = 81 exact code positions are really effective for our genetic code and encode the amino acids, compiled to proteins. This very important discovery leads to two completely new results that are limits-overlooking: 1) 34 (=81) genetic code positions mean exactly the same number as there are stable and naturally existing chemical elements in our universe. This famous argument should now lead to some alternative, as well as new fundamental conclusions about our existence. 2) A genetic code positioning system shows that nature is much smarter than expected: mutations are made less dangerous than believed, because they won't be that easily able any more to cause severe damages in the protein-synthesis. This should also lead to some alternative views upon evolution of life.}, language = {en} } @article{VoegeleRuebbelkeGovorukhaetal.2019, author = {V{\"o}gele, Stefan and R{\"u}bbelke, Dirk and Govorukha, Kristina and Grajewski, Matthias}, title = {Socio-technical scenarios for energy-intensive industries: the future of steel production in Germany}, series = {Climatic Change}, journal = {Climatic Change}, publisher = {Springer}, address = {Berlin}, issn = {0165-0009}, doi = {10.1007/s10584-019-02366-0}, pages = {1 -- 16}, year = {2019}, language = {en} } @article{PoghossianWagnerSchoening2009, author = {Poghossian, Arshak and Wagner, Holger and Sch{\"o}ning, Michael Josef}, title = {Functional testing and characterisation of (bio-)chemical sensors on wafer level}, series = {Procedia Chemistry. 1 (2009), H. 1}, journal = {Procedia Chemistry. 1 (2009), H. 1}, isbn = {1876-6196}, pages = {835 -- 838}, year = {2009}, language = {en} } @article{AbouzarPoghossianSiqueiraetal.2010, author = {Abouzar, Maryam H. and Poghossian, Arshak and Siqueira, Jos{\´e} R. Jr. and Oliveira, Osvaldo N. Jr. and Moritz, Werner and Sch{\"o}ning, Michael Josef}, title = {Capacitive electrolyte-insulator-semiconductor structures functionalised with a polyelectrolyte/enzyme multilayer: New strategy for enhanced field-effect biosensing}, series = {Physica Status Solidi (A). 207 (2010), H. 4}, journal = {Physica Status Solidi (A). 207 (2010), H. 4}, isbn = {1862-6300}, pages = {884 -- 890}, year = {2010}, language = {en} } @article{PoghossianIngebrandtOffenhaeusseretal.2009, author = {Poghossian, Arshak and Ingebrandt, S. and Offenh{\"a}usser, A. and Sch{\"o}ning, Michael Josef}, title = {Field-effect devices for detecting cellular signals}, series = {Seminars in Cell \& Developmental Biology. 20 (2009), H. 1}, journal = {Seminars in Cell \& Developmental Biology. 20 (2009), H. 1}, publisher = {Elsevier}, address = {Amsterdam}, isbn = {1096-3634}, pages = {41 -- 48}, year = {2009}, language = {en} } @article{TranStaat2010, author = {Tran, Thanh Ngoc and Staat, Manfred}, title = {Shakedown analysis of two dimensional structures by an edge-based smoothed finite element method}, pages = {1 -- 7}, year = {2010}, language = {en} } @article{DigelTemizArtmann2011, author = {Digel, Ilya and Temiz Artmann, Ayseg{\"u}l}, title = {The emperor's new body : seeking for a blueprint of limb regeneration in humans}, series = {Stem cell engineering : principles and applications / Gerhard M. Artmann ... eds.}, journal = {Stem cell engineering : principles and applications / Gerhard M. Artmann ... eds.}, publisher = {Springer}, address = {Berlin [u.a.]}, isbn = {978-3-642-11864-7}, pages = {3 -- 37}, year = {2011}, language = {en} } @article{LeschingerBeschAydinetal.2019, author = {Leschinger, Tim and Besch, Katharina and Aydin, Cansu and Staat, Manfred and Scaal, Martin and M{\"u}ller, Lars Peter and Wegmann, Kilian}, title = {Irreparable rotator cuff tears: a biomechanical comparison of superior capsuloligamentous complex reconstruction techniques and an interposition graft technique}, series = {The Orthopaedic Journal of Sports Medicine}, volume = {7}, journal = {The Orthopaedic Journal of Sports Medicine}, number = {8}, doi = {10.1177/2325967119864590}, pages = {1 -- 5}, year = {2019}, language = {en} } @phdthesis{Tran2019, author = {Tran, Ngoc Trinh}, title = {Limit and Shakedown analysis of structures under stochastic conditions}, publisher = {Technische Universit{\"a}t Braunschweig}, address = {Braunschweig}, doi = {10.24355/dbbs.084-201902121135-0}, pages = {166 S.}, year = {2019}, language = {en} } @article{SiqueiraBaeckerPoghossianetal.2010, author = {Siqueira, Jos{\´e} R. Jr. and B{\"a}cker, Matthias and Poghossian, Arshak and Zucolotto, Valtencir and Oliveira, Osvaldo N. Jr. and Sch{\"o}ning, Michael Josef}, title = {Associating biosensing properties with the morphological structure of multilayers containing carbon nanotubes on field-effect devices}, series = {Physica status solidi (a). 207 (2010), H. 4}, journal = {Physica status solidi (a). 207 (2010), H. 4}, isbn = {1862-6300}, pages = {781 -- 786}, year = {2010}, language = {en} } @inproceedings{BuniatyanHuckPoghossianetal.2014, author = {Buniatyan, V. V. and Huck, Christina and Poghossian, Arshak and Sch{\"o}ning, Michael Josef and Rustamyan, L. G. and Hovnikyan, H. H.}, title = {Equivalent circuit and optimization of impedance characteristics of an electrolyte conductivity sensor}, series = {Proceedings of State Engineering University Armenia : Series Information technologies, electronics, radio engineering}, volume = {Iss. 17}, booktitle = {Proceedings of State Engineering University Armenia : Series Information technologies, electronics, radio engineering}, number = {No. 1}, pages = {69 -- 76}, year = {2014}, language = {en} } @article{NaetherRolkaPoghossianetal.2005, author = {N{\"a}ther, Niko and Rolka, David and Poghossian, Arshak and Koudelka-Hep, M. and Sch{\"o}ning, Michael Josef}, title = {Two microcell flow-injection analysis (FIA) platforms for capacitive silicon-based field-effect sensors}, series = {Electrochimica Acta. 51 (2005), H. 5}, journal = {Electrochimica Acta. 51 (2005), H. 5}, isbn = {0013-4686}, doi = {10.1016/j.electacta.2005.04.066}, pages = {924 -- 929}, year = {2005}, language = {en} } @article{StulpeBjelakovic2005, author = {Stulpe, Werner and Bjelakovic, Igor}, title = {The Projective Hilbert Space as a Classical Phase Space for Nonrelativistic Quantum Dynamics. Bjelakovic, Igor; Stulpe, Werner}, series = {International Journal of Theoretical Physics. 44 (2005), H. 11}, journal = {International Journal of Theoretical Physics. 44 (2005), H. 11}, isbn = {1572-9575}, pages = {2041 -- 2049}, year = {2005}, language = {en} } @article{PoghossianCherstvyIngebrandtetal.2005, author = {Poghossian, Arshak and Cherstvy, A. and Ingebrandt, S. and Offenh{\"a}usser, A. and Sch{\"o}ning, Michael Josef}, title = {Possibilities and limitations of label-free detection of DNA hybridization with field-effect-based devices}, series = {Sensors and Actuators B. 111-112 (2005)}, journal = {Sensors and Actuators B. 111-112 (2005)}, isbn = {0925-4005}, pages = {470 -- 480}, year = {2005}, language = {en} } @article{PitaKraemerZouhetal.2008, author = {Pita, Marcos and Kr{\"a}mer, Melina and Zouh, Jian and Poghossian, Arshak and Sch{\"o}ning, Michael Josef and Fernandez, Victor M. and Katz, Evgeny}, title = {Optoelectronic Properties of Nanostructured Ensembles Controlled by Biomolecular Logic Systems}, series = {ACS Nano. 10 (2008), H. 2}, journal = {ACS Nano. 10 (2008), H. 2}, isbn = {1936-086X}, pages = {2160 -- 2166}, year = {2008}, language = {en} } @incollection{PoghossianSchusserBaeckeretal.2015, author = {Poghossian, Arshak and Schusser, Sebastian and B{\"a}cker, M. and Leinhos, Marcel and Sch{\"o}ning, Michael Josef}, title = {Real-time in-situ electrical monitoring of the degradation of biopolymers using semiconductor field-effect devices}, series = {Biodegradable biopolymers. Vol. 1}, booktitle = {Biodegradable biopolymers. Vol. 1}, publisher = {Nova Science Publ.}, address = {Hauppauge}, isbn = {978-1-63483-632-6}, pages = {135 -- 153}, year = {2015}, language = {en} } @article{MaggakisKelemenDigelArtmann2005, author = {Maggakis-Kelemen, Christina and Digel, Ilya and Artmann, Gerhard}, title = {Polystyrene sulfonate/Polyallylamine hydrochloride microcapsules as potential artificial red blood cells - improvement of capsule flexibility}, series = {Biomedizinische Technik. 50 (2005), H. Erg.-Bd. 1}, journal = {Biomedizinische Technik. 50 (2005), H. Erg.-Bd. 1}, pages = {324 -- 326}, year = {2005}, language = {en} } @inproceedings{PoghossianBronderWuetal.2015, author = {Poghossian, Arshak and Bronder, Thomas and Wu, Chunsheng and Sch{\"o}ning, Michael Josef}, title = {Label-free sensing of biomolecules by their intrinsic molecular charge using field-effect devices}, series = {Semiconductor Micro- and Nanoelectonics : Proceedings of the tenth international conference, Yerevan, Armenia, September 11-13}, booktitle = {Semiconductor Micro- and Nanoelectonics : Proceedings of the tenth international conference, Yerevan, Armenia, September 11-13}, isbn = {978-5-8084-1991-9}, pages = {61 -- 63}, year = {2015}, language = {en} } @article{GasparyanPoghossianVitusevichetal.2011, author = {Gasparyan, Ferdinand V. and Poghossian, Arshak and Vitusevich, Svetlana A. and Petrychuk, Mykhaylo V. and Sydoruk, Viktor A. and Siqueira, Jos{\´e} R. Jr. and Oliveira, Osvaldo N. Jr. and Offenh{\"a}usser, Andreas and Sch{\"o}ning, Michael Josef}, title = {Low-Frequency Noise in Field-Effect Devices Functionalized With Dendrimer/Carbon-Nanotube Multilayers}, series = {IEEE Sensors Journal. 11 (2011), H. 1}, journal = {IEEE Sensors Journal. 11 (2011), H. 1}, publisher = {IEEE}, address = {New York}, isbn = {1530-437X}, pages = {142 -- 149}, year = {2011}, language = {en} } @inproceedings{JablonskiKochBronderetal.2017, author = {Jablonski, Melanie and Koch, Claudia and Bronder, Thomas and Poghossian, Arshak and Wege, Christina and Sch{\"o}ning, Michael Josef}, title = {Field-Effect Biosensors Modified with Tobacco Mosaic Virus Nanotubes as Enzyme Nanocarrier}, series = {MDPI Proceeding}, volume = {1}, booktitle = {MDPI Proceeding}, number = {4}, doi = {10.3390/proceedings1040505}, pages = {4}, year = {2017}, language = {en} } @inproceedings{PhamNguyenStaat2012, author = {Pham, Phu Tinh and Nguyen, Thanh Ngoc and Staat, Manfred}, title = {FEM based shakedown analysis of hardening structures}, series = {Proceedings International Conference on Advances in Computational Mechanics (ACOME)}, booktitle = {Proceedings International Conference on Advances in Computational Mechanics (ACOME)}, pages = {870 -- 882}, year = {2012}, language = {en} } @incollection{PoghossianSchoening2017, author = {Poghossian, Arshak and Sch{\"o}ning, Michael Josef}, title = {Nanomaterial-Modified Capacitive Field-Effect Biosensors}, series = {Springer Series on Chemical Sensors and Biosensors (Methods and Applications)}, booktitle = {Springer Series on Chemical Sensors and Biosensors (Methods and Applications)}, publisher = {Springer}, address = {Berlin, Heidelberg}, doi = {10.1007/5346_2017_2}, pages = {1 -- 25}, year = {2017}, abstract = {The coupling of charged molecules, nanoparticles, and more generally, inorganic/organic nanohybrids with semiconductor field-effect devices based on an electrolyte-insulator-semiconductor (EIS) system represents a very promising strategy for the active tuning of electrochemical properties of these devices and, thus, opening new opportunities for label-free biosensing by the intrinsic charge of molecules. The simplest field-effect sensor is a capacitive EIS sensor, which represents a (bio-)chemically sensitive capacitor. In this chapter, selected examples of recent developments in the field of label-free biosensing using nanomaterial-modified capacitive EIS sensors are summarized. In the first part, we present applications of EIS sensors modified with negatively charged gold nanoparticles for the label-free electrostatic detection of positively charged small proteins and macromolecules, for monitoring the layer-by-layer formation of oppositely charged polyelectrolyte (PE) multilayers as well as for the development of an enzyme-based biomolecular logic gate. In the second part, examples of a label-free detection by means of EIS sensors modified with a positively charged weak PE layer are demonstrated. These include electrical detection of on-chip and in-solution hybridized DNA (deoxyribonucleic acid) as well as an EIS sensor with pH-responsive weak PE/enzyme multilayers for enhanced field-effect biosensing.}, language = {en} } @article{Digel2010, author = {Digel, Ilya}, title = {In-situ biological decontamination of an ice melting probe}, year = {2010}, language = {en} } @article{StulpeScholz2009, author = {Stulpe, Werner and Scholz, Erhard}, title = {Hilbert Space / Scholz, Erhard ; Stulpe, Werner}, series = {Compendium of Quantum Physics : concepts, experiments, history and philosophy / Daniel Greenberger ... ed.}, journal = {Compendium of Quantum Physics : concepts, experiments, history and philosophy / Daniel Greenberger ... ed.}, publisher = {Springer}, address = {Berlin}, isbn = {978-3-540-70622-9}, pages = {291 -- 295}, year = {2009}, language = {en} } @article{Stulpe2009, author = {Stulpe, Werner}, title = {Density Operator}, series = {Compendium of Quantum Physics : concepts, experiments, history and philosophy / Daniel Greenberger ... ed.}, journal = {Compendium of Quantum Physics : concepts, experiments, history and philosophy / Daniel Greenberger ... ed.}, publisher = {Springer}, address = {Berlin}, isbn = {978-3-540-70622-9}, pages = {166 -- 169}, year = {2009}, language = {en} } @article{TranStaat2020, author = {Tran, Ngoc Trinh and Staat, Manfred}, title = {Direct plastic structural design under lognormally distributed strength by chance constrained programming}, series = {Optimization and Engineering}, volume = {21}, journal = {Optimization and Engineering}, number = {1}, publisher = {Springer Nature}, address = {Cham}, issn = {1573-2924}, doi = {10.1007/s11081-019-09437-2}, pages = {131 -- 157}, year = {2020}, abstract = {We propose the so-called chance constrained programming model of stochastic programming theory to analyze limit and shakedown loads of structures under random strength with a lognormal distribution. A dual chance constrained programming algorithm is developed to calculate simultaneously both the upper and lower bounds of the plastic collapse limit and the shakedown limit. The edge-based smoothed finite element method (ES-FEM) is used with three-node linear triangular elements.}, language = {en} } @article{GunGutkinLevetal.2011, author = {Gun, Jenny and Gutkin, Vitaly and Lev, Ovadia and Boyen, Hans-Gerd and Saitner, Marc and Wagner, Patrick and Olieslaeger, Marc D´ and Abouzar, Maryam H. and Poghossian, Arshak and Sch{\"o}ning, Michael Josef}, title = {Tracing gold nanoparticle charge by electrolyte-insulator-semiconductor devices}, series = {Journal of Physical Chemistry C. 115 (2011), H. 11}, journal = {Journal of Physical Chemistry C. 115 (2011), H. 11}, publisher = {American Cemical Society}, address = {Washington, DC}, isbn = {1932-7455}, pages = {4439 -- 4445}, year = {2011}, language = {en} } @article{GunRizkovLevetal.2008, author = {Gun, Jenny and Rizkov, Dan and Lev, Ovadia and Abouzar, Maryam H. and Poghossian, Arshak and Sch{\"o}ning, Michael Josef}, title = {Oxygen plasma-treated gold nanoparticle-based field-effect devices as transducer structures for bio-chemical sensing}, series = {Microchimica Acta. 164 (2008), H. 3-4}, journal = {Microchimica Acta. 164 (2008), H. 3-4}, isbn = {1436-5073}, pages = {395 -- 404}, year = {2008}, language = {en} } @article{PoghossianYoshinobuSchoening2003, author = {Poghossian, Arshak and Yoshinobu, Tatsuo and Sch{\"o}ning, Michael Josef}, title = {Flow-velocity microsensors based on semiconductor field-effect structures}, series = {Sensors. 3 (2003), H. 7}, journal = {Sensors. 3 (2003), H. 7}, isbn = {1424-8220}, pages = {202 -- 212}, year = {2003}, language = {en} } @article{DigelDemirciTemizArtmannetal.2004, author = {Digel, Ilya and Demirci, Taylan and Temiz Artmann, Ayseg{\"u}l and Nishikawa, K.}, title = {Free Radical Nature of the Bactericidal Effect of Plasma-Generated Cluster Ions (PCIs)}, series = {Biomedizinische Technik. 49 (2004), H. Erg.-Bd. 2}, journal = {Biomedizinische Technik. 49 (2004), H. Erg.-Bd. 2}, isbn = {0932-4666}, pages = {982 -- 983}, year = {2004}, language = {en} } @incollection{PoghossianSchoening2006, author = {Poghossian, Arshak and Sch{\"o}ning, Michael Josef}, title = {Silicon-based chemical and biological field-effect sensors}, series = {Encyclopedia of Sensors. Vol. 9 S - Sk}, booktitle = {Encyclopedia of Sensors. Vol. 9 S - Sk}, publisher = {ASP, American Scientific Publ.}, address = {Stevenson Ranch, Calif.}, isbn = {1-58883-065-9}, pages = {463 -- 534}, year = {2006}, language = {en} } @article{PoghossianAbouzarChristiaensetal.2008, author = {Poghossian, Arshak and Abouzar, Maryam H. and Christiaens, P. and Williams, O. A. and Haenen, K. and Wagner, Patrick and Sch{\"o}ning, Michael Josef}, title = {Sensing charged macromolecules with nanocrystalline diamond-based field-effect capacitive sensors}, series = {Journal of Contemporary Physics. 43 (2008), H. 2}, journal = {Journal of Contemporary Physics. 43 (2008), H. 2}, isbn = {1934-9378}, pages = {77 -- 81}, year = {2008}, language = {en} } @article{IngebrandtHanNakamuraetal.2007, author = {Ingebrandt, S. and Han, Y. and Nakamura, F. and Poghossian, Arshak and Sch{\"o}ning, Michael Josef and Offenh{\"a}usser, A.}, title = {Label-free detection of single nucleotide polymorphisms utilizing the differential transfer function of field-effect transistors}, series = {Biosensors and Bioelectronics. 22 (2007), H. 12}, journal = {Biosensors and Bioelectronics. 22 (2007), H. 12}, isbn = {0956-5663}, pages = {2834 -- 2840}, year = {2007}, language = {en} } @article{BronderWuPoghossianetal.2014, author = {Bronder, Thomas and Wu, Chunsheng and Poghossian, Arshak and Werner, Frederik and Keusgen, M. and Sch{\"o}ning, Michael Josef}, title = {Label-free detection of DNA hybridization with light-addressable potentiometric sensors: comparison of various DNA-immobilization strategies}, series = {Procedia Engineering}, volume = {87}, journal = {Procedia Engineering}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1877-7058}, doi = {10.1016/j.proeng.2014.11.647}, pages = {755 -- 758}, year = {2014}, abstract = {Light-addressable potentiometric sensors (LAPS) consisting of a p-Si-SiO2 and p-Si-SiO2-Au structure, respectively, have been tested for a label-free electrical detection of DNA (deoxyribonucleic acid) hybridization. Three different strategies for immobilizing single-stranded probe DNA (ssDNA) molecules on a LAPS surface have been studied and compared: (a) immobilization of thiol-modified ssDNA on the patterned Au surface via gold-thiol bond, (b) covalent immobilization of amino-modified ssDNA onto the SiO2 surface functionalized with 3-aminopropyltriethoxysilane and (c) layer-by-layer adsorption of negatively charged ssDNA on a positively charged weak polyelectrolyte layer of poly(allylamine hydrochloride).}, language = {en} } @article{KatzPoghossianSchoening2017, author = {Katz, Evgeny and Poghossian, Arshak and Sch{\"o}ning, Michael Josef}, title = {Enzyme-based logic gates and circuits - analytical applications and interfacing with electronics}, series = {Analytical and Bioanalytical Chemistry}, volume = {409}, journal = {Analytical and Bioanalytical Chemistry}, publisher = {Springer}, address = {Berlin}, issn = {1618-2650}, doi = {10.1007/s00216-016-0079-7}, pages = {81 -- 94}, year = {2017}, abstract = {The paper is an overview of enzyme-based logic gates and their short circuits, with specific examples of Boolean AND and OR gates, and concatenated logic gates composed of multi-step enzyme-biocatalyzed reactions. Noise formation in the biocatalytic reactions and its decrease by adding a "filter" system, converting convex to sigmoid response function, are discussed. Despite the fact that the enzyme-based logic gates are primarily considered as components of future biomolecular computing systems, their biosensing applications are promising for immediate practical use. Analytical use of the enzyme logic systems in biomedical and forensic applications is discussed and exemplified with the logic analysis of biomarkers of various injuries, e.g., liver injury, and with analysis of biomarkers characteristic of different ethnicity found in blood samples on a crime scene. Interfacing of enzyme logic systems with modified electrodes and semiconductor devices is discussed, giving particular attention to the interfaces functionalized with signal-responsive materials. Future perspectives in the design of the biomolecular logic systems and their applications are discussed in the conclusion.}, language = {en} } @article{PoghossianSchoening2020, author = {Poghossian, Arshak and Sch{\"o}ning, Michael Josef}, title = {Capacitive field-effect eis chemical sensors and biosensors: A status report}, series = {Sensors}, volume = {20}, journal = {Sensors}, number = {19}, publisher = {MDPI}, address = {Basel}, issn = {1424-8220}, doi = {10.3390/s20195639}, pages = {Artikel 5639}, year = {2020}, abstract = {Electrolyte-insulator-semiconductor (EIS) field-effect sensors belong to a new generation of electronic chips for biochemical sensing, enabling a direct electronic readout. The review gives an overview on recent advances and current trends in the research and development of chemical sensors and biosensors based on the capacitive field-effect EIS structure—the simplest field-effect device, which represents a biochemically sensitive capacitor. Fundamental concepts, physicochemical phenomena underlying the transduction mechanism and application of capacitive EIS sensors for the detection of pH, ion concentrations, and enzymatic reactions, as well as the label-free detection of charged molecules (nucleic acids, proteins, and polyelectrolytes) and nanoparticles, are presented and discussed.}, language = {en} } @article{StulpeBugajskiHellwig1998, author = {Stulpe, Werner and Bugajski, S. and Hellwig, K.-E.}, title = {On Fuzzy Random Variables and Statistical Maps. Bugajski, S.; Hellwig, K.-E.; Stulpe, W.}, series = {Reports on Mathematical Physics. 41 (1998), H. 1}, journal = {Reports on Mathematical Physics. 41 (1998), H. 1}, isbn = {0034-4877}, pages = {1 -- 11}, year = {1998}, language = {en} } @article{Staat2012, author = {Staat, Manfred}, title = {Limit and shakedown analysis under uncertainty}, series = {Tap chi Khoa hoc \& ung dung - Dai hoc Ton Duc Thang}, volume = {19}, journal = {Tap chi Khoa hoc \& ung dung - Dai hoc Ton Duc Thang}, pages = {45 -- 47}, year = {2012}, language = {en} } @article{MolinnusHardtSiegertetal.2018, author = {Molinnus, Denise and Hardt, Gabriel and Siegert, Petra and Willenberg, Holger S. and Poghossian, Arshak and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Detection of Adrenaline in Blood Plasma as Biomarker for Adrenal Venous Sampling}, series = {Electroanalysis}, volume = {30}, journal = {Electroanalysis}, number = {5}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1521-4109}, doi = {10.1002/elan.201800026}, pages = {937 -- 942}, year = {2018}, abstract = {An amperometric bi-enzyme biosensor based on substrate recycling principle for the amplification of the sensor signal has been developed for the detection of adrenaline in blood. Adrenaline can be used as biomarker verifying successful adrenal venous sampling procedure. The adrenaline biosensor has been realized via modification of a galvanic oxygen sensor with a bi-enzyme membrane combining a genetically modified laccase and a pyrroloquinoline quinone-dependent glucose dehydrogenase. The measurement conditions such as pH value and temperature were optimized to enhance the sensor performance. A high sensitivity and a low detection limit of about 0.5-1 nM adrenaline have been achieved in phosphate buffer at pH 7.4, relevant for measurements in blood samples. The sensitivity of the biosensor to other catecholamines such as noradrenaline, dopamine and dobutamine has been studied. Finally, the sensor has been successfully applied for the detection of adrenaline in human blood plasma.}, language = {en} } @article{PoghossianAbouzarChristiaensetal.2007, author = {Poghossian, Arshak and Abouzar, Maryam H. and Christiaens, P. and Williams, O. A. and Haenen, K. and Wagner, P. and Sch{\"o}ning, Michael Josef}, title = {Nanocrystalline diamond-based field-effect (bio-)chemical sensor}, series = {8. Dresdner Sensor-Symposium : Sensoren f{\"u}r Umwelt, Klima und Sicherheit, Biosensoren und Biosysteme, Sensoren und Sensorsysteme f{\"u}r die Prozesstechnik, Trends in der Sensortechnik, Materialentwicklung f{\"u}r die Sensorik; 8. Dresdner Sensor-Symposium, 10. - 12. Dezember 2007, Dresden / Gerald Gerlach ... (Hg.)}, journal = {8. Dresdner Sensor-Symposium : Sensoren f{\"u}r Umwelt, Klima und Sicherheit, Biosensoren und Biosysteme, Sensoren und Sensorsysteme f{\"u}r die Prozesstechnik, Trends in der Sensortechnik, Materialentwicklung f{\"u}r die Sensorik; 8. Dresdner Sensor-Symposium, 10. - 12. Dezember 2007, Dresden / Gerald Gerlach ... (Hg.)}, publisher = {TUDpress, Verl. der Wissenschaften}, address = {Dresden}, isbn = {978-3-940046-45-1}, pages = {191 -- 194}, year = {2007}, language = {en} } @inproceedings{BegingPoghossianMlyneketal.2010, author = {Beging, Stefan and Poghossian, Arshak and Mlynek, D. and Hataihimakul, S. and Pedraza, A. and Dhawan, S. and Laube, N. and Kleinen, L. and Baldsiefen, G. and Busch, H. and Sch{\"o}ning, Michael Josef}, title = {Ion-selective sensors for the determination of the risk of urinary stone formation}, series = {Micro- and Nanosystems in biochemical diagnosis : Principles and applications}, booktitle = {Micro- and Nanosystems in biochemical diagnosis : Principles and applications}, address = {Warsaw}, pages = {74 -- 80}, year = {2010}, language = {en} } @phdthesis{Tran2008, author = {Tran, Thanh Ngoc}, title = {Limit and shakedown analysis of plates and shells including uncertainties}, year = {2008}, language = {en} } @article{SchusserKrischerBaeckeretal.2015, author = {Schusser, Sebastian and Krischer, Maximillian and B{\"a}cker, Matthias and Poghossian, Arshak and Wagner, Patrick and Sch{\"o}ning, Michael Josef}, title = {Monitoring of the Enzymatically Catalyzed Degradation of Biodegradable Polymers by Means of Capacitive Field-Effect Sensors}, series = {Analytical Chemistry}, volume = {87}, journal = {Analytical Chemistry}, number = {13}, publisher = {ACS Publications}, address = {Washington, DC}, issn = {1520-6882}, doi = {10.1021/acs.analchem.5b00617}, pages = {6607 -- 6613}, year = {2015}, abstract = {Designing novel or optimizing existing biodegradable polymers for biomedical applications requires numerous tests on the effect of substances on the degradation process. In the present work, polymer-modified electrolyte-insulator-semiconductor (PMEIS) sensors have been applied for monitoring an enzymatically catalyzed degradation of polymers for the first time. The thin films of biodegradable polymer poly(d,l-lactic acid) and enzyme lipase were used as a model system. During degradation, the sensors were read-out by means of impedance spectroscopy. In order to interpret the data obtained from impedance measurements, an electrical equivalent circuit model was developed. In addition, morphological investigations of the polymer surface have been performed by means of in situ atomic force microscopy. The sensor signal change, which reflects the progress of degradation, indicates an accelerated degradation in the presence of the enzyme compared to hydrolysis in neutral pH buffer media. The degradation rate increases with increasing enzyme concentration. The obtained results demonstrate the potential of PMEIS sensors as a very promising tool for in situ and real-time monitoring of degradation of polymers.}, language = {en} } @article{KramerHalamkovaPoghossianetal.2013, author = {Kramer, Friederike and Halamkova, Lenka and Poghossian, Arshak and Sch{\"o}ning, Michael Josef and Katz, Evgeny and Halamek, Jan}, title = {Biocatalytic analysis of biomarkers for forensic identification of ethnicity between Caucasian and African American}, series = {The analyst. August 2013}, volume = {Vol. 138}, journal = {The analyst. August 2013}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, issn = {1364-5528 (E-Journal); 0003-2654 (Print)}, pages = {6251 -- 6257}, year = {2013}, language = {en} } @inproceedings{BaeckerSchusserLeinhosetal.2014, author = {B{\"a}cker, Matthias and Schusser, Sebastian and Leinhos, Marcel and Poghossian, Arshak and Sch{\"o}ning, Michael Josef}, title = {Sensor system for the monitoring of degradation processes of biodegradable biopolymers}, series = {Sensoren und Messsysteme 2014 ; Beitr{\"a}ge der 17. GMA/ITG-Fachtagung vom 3. bis 4. Juni 2014 in N{\"u}rnberg. (ITG-Fachbericht ; 250)}, booktitle = {Sensoren und Messsysteme 2014 ; Beitr{\"a}ge der 17. GMA/ITG-Fachtagung vom 3. bis 4. Juni 2014 in N{\"u}rnberg. (ITG-Fachbericht ; 250)}, publisher = {VDE-Verl.}, address = {D{\"u}sseldorf}, organization = {VDI/VDE-Gesellschaft Mess- und Automatisierungstechnik}, isbn = {978-3-8007-3622-5}, pages = {1 -- 4}, year = {2014}, language = {en} } @article{LeversStaatLaack2016, author = {Levers, A. and Staat, Manfred and Laack, Walter van}, title = {Analysis of the long-term effect of the MBST® nuclear magnetic resonance therapy on gonarthrosis}, series = {Orthopedic Practice}, volume = {47}, journal = {Orthopedic Practice}, number = {11}, pages = {521 -- 528}, year = {2016}, language = {en} } @article{HorstmannBialonskiNoenningetal.2010, author = {Horstmann, Marie-Therese and Bialonski, Stephan and Noenning, Nina and Mai, Heinke and Prusseit, Jens and Wellmer, J{\"o}rg and Hinrichs, Hermann and Lehnertz, Klaus}, title = {State dependent properties of epileptic brain networks: Comparative graph-theoretical analyses of simultaneously recorded EEG and MEG}, series = {Clinical Neurophysiology}, volume = {121}, journal = {Clinical Neurophysiology}, number = {2}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1388-2457}, doi = {10.1016/j.clinph.2009.10.013}, pages = {172 -- 185}, year = {2010}, abstract = {Objective To investigate whether functional brain networks of epilepsy patients treated with antiepileptic medication differ from networks of healthy controls even during the seizure-free interval. Methods We applied different rules to construct binary and weighted networks from EEG and MEG data recorded under a resting-state eyes-open and eyes-closed condition from 21 epilepsy patients and 23 healthy controls. The average shortest path length and the clustering coefficient served as global statistical network characteristics. Results Independent on the behavioral condition, epileptic brains exhibited a more regular functional network structure. Similarly, the eyes-closed condition was characterized by a more regular functional network structure in both groups. The amount of network reorganization due to behavioral state changes was similar in both groups. Consistent findings could be achieved for networks derived from EEG but hardly from MEG recordings, and network construction rules had a rather strong impact on our findings. Conclusions Despite the locality of the investigated processes epileptic brain networks differ in their global characteristics from non-epileptic brain networks. Further methodological developments are necessary to improve the characterization of disturbed and normal functional networks. Significance An increased regularity and a diminished modulation capability appear characteristic of epileptic brain networks.}, language = {en} } @article{BaeckerRakowskiPoghossianetal.2013, author = {B{\"a}cker, Matthias and Rakowski, D. and Poghossian, Arshak and Biselli, Manfred and Wagner, Patrick and Sch{\"o}ning, Michael Josef}, title = {Chip-based amperometric enzyme sensor system for monitoring of bioprocesses by flow-injection analysis}, series = {Journal of Biotechnology}, volume = {163}, journal = {Journal of Biotechnology}, number = {4}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0168-1656}, doi = {10.1016/j.jbiotec.2012.03.014}, pages = {371 -- 376}, year = {2013}, abstract = {A microfluidic chip integrating amperometric enzyme sensors for the detection of glucose, glutamate and glutamine in cell-culture fermentation processes has been developed. The enzymes glucose oxidase, glutamate oxidase and glutaminase were immobilized by means of cross-linking with glutaraldehyde on platinum thin-film electrodes integrated within a microfluidic channel. The biosensor chip was coupled to a flow-injection analysis system for electrochemical characterization of the sensors. The sensors have been characterized in terms of sensitivity, linear working range and detection limit. The sensitivity evaluated from the respective peak areas was 1.47, 3.68 and 0.28 μAs/mM for the glucose, glutamate and glutamine sensor, respectively. The calibration curves were linear up to a concentration of 20 mM glucose and glutamine and up to 10 mM for glutamate. The lower detection limit amounted to be 0.05 mM for the glucose and glutamate sensor, respectively, and 0.1 mM for the glutamine sensor. Experiments in cell-culture medium have demonstrated a good correlation between the glutamate, glutamine and glucose concentrations measured with the chip-based biosensors in a differential-mode and the commercially available instrumentation. The obtained results demonstrate the feasibility of the realized microfluidic biosensor chip for monitoring of bioprocesses.}, language = {en} } @article{HuckPoghossianWagneretal.2012, author = {Huck, Christina and Poghossian, Arshak and Wagner, Patrick and Sch{\"o}ning, Michael Josef}, title = {Combined amperometric/field-effect sensor for the detection of dissolved hydrogen}, series = {Sensors and actuators B: Chemical}, volume = {187}, journal = {Sensors and actuators B: Chemical}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0925-4005}, doi = {10.1016/j.snb.2012.10.050}, pages = {168 -- 173}, year = {2012}, abstract = {Real-time and reliable monitoring of the biogas process is crucial for a stable and efficient operation of biogas production in order to avoid digester breakdowns. The concentration of dissolved hydrogen (H₂) represents one of the key parameters for biogas process control. In this work, a one-chip integrated combined amperometric/field-effect sensor for monitoring the dissolved H₂ concentration has been developed for biogas applications. The combination of two different transducer principles might allow a more accurate and reliable measurement of dissolved H₂ as an early warning indicator of digester failures. The feasibility of the approach has been demonstrated by simultaneous amperometric/field-effect measurements of dissolved H₂ concentrations in electrolyte solutions. Both, the amperometric and the field-effect transducer show a linear response behaviour in the H₂ concentration range from 0.1 to 3\% (v/v) with a slope of 198.4 ± 13.7 nA/\% (v/v) and 14.9 ± 0.5 mV/\% (v/v), respectively.}, language = {en} }