@article{UysalFiratCreutzetal.2022,
  author    = {Uysal, Karya and Firat, Ipek Serat and Creutz, Till and Aydin, Inci Cansu and Artmann, Gerhard and Teusch, Nicole and Temiz Artmann, Ayseg{\"u}l},
  title     = {A novel in vitro wound healing assay using free-standing, ultra-thin PDMS membranes},
  series = {membranes},
  volume    = {2023},
  journal   = {membranes},
  number    = {13(1)},
  publisher = {MDPI},
  address   = {Basel},
  doi       = {10.3390/membranes13010022},
  pages     = {Artikel 22},
  year      = {2022},
  abstract  = {Advances in polymer science have significantly increased polymer applications in life sciences. We report the use of free-standing, ultra-thin polydimethylsiloxane (PDMS) membranes, called CellDrum, as cell culture substrates for an in vitro wound model. Dermal fibroblast monolayers from 28- and 88-year-old donors were cultured on CellDrums. By using stainless steel balls, circular cell-free areas were created in the cell layer (wounding). Sinusoidal strain of 1 Hz, 5\% strain, was applied to membranes for 30 min in 4 sessions. The gap circumference and closure rate of un-stretched samples (controls) and stretched samples were monitored over 4 days to investigate the effects of donor age and mechanical strain on wound closure. A significant decrease in gap circumference and an increase in gap closure rate were observed in trained samples from younger donors and control samples from older donors. In contrast, a significant decrease in gap closure rate and an increase in wound circumference were observed in the trained samples from older donors. Through these results, we propose the model of a cell monolayer on stretchable CellDrums as a practical tool for wound healing research. The combination of biomechanical cell loading in conjunction with analyses such as gene/protein expression seems promising beyond the scope published here.},
  language  = {en}
}
@article{BayerTemizArtmannDigeletal.2020,
  author    = {Bayer, Robin and Temiz Artmann, Ayseg{\"u}l and Digel, Ilya and Falkenstein, Julia and Artmann, Gerhard and Creutz, Till and Hescheler, J{\"u}rgen},
  title     = {Mechano-pharmacological testing of L-Type Ca²⁺ channel modulators via human vascular celldrum model},
  series = {Cellular Physiology and Biochemistry},
  volume    = {54},
  journal   = {Cellular Physiology and Biochemistry},
  publisher = {Cell Physiol Biochem Press},
  address   = {D{\"u}sseldorf},
  issn      = {1421-9778},
  doi       = {10.33594/000000225},
  pages     = {371 -- 383},
  year      = {2020},
  abstract  = {Background/Aims: This study aimed to establish a precise and well-defined working model, assessing pharmaceutical effects on vascular smooth muscle cell monolayer in-vitro. It describes various analysis techniques to determine the most suitable to measure the biomechanical impact of vasoactive agents by using CellDrum technology. Methods: The so-called CellDrum technology was applied to analyse the biomechanical properties of confluent human aorta muscle cells (haSMC) in monolayer. The cell generated tensions deviations in the range of a few N/m² are evaluated by the CellDrum technology. This study focuses on the dilative and contractive effects of L-type Ca²⁺ channel agonists and antagonists, respectively. We analyzed the effects of Bay K8644, nifedipine and verapamil. Three different measurement modes were developed and applied to determine the most appropriate analysis technique for the study purpose. These three operation modes are called, particular time mode" (PTM), "long term mode" (LTM) and "real-time mode" (RTM). Results: It was possible to quantify the biomechanical response of haSMCs to the addition of vasoactive agents using CellDrum technology. Due to the supplementation of 100nM Bay K8644, the tension increased approximately 10.6\% from initial tension maximum, whereas, the treatment with nifedipine and verapamil caused a significant decrease in cellular tension: 10nM nifedipine decreased the biomechanical stress around 6,5\% and 50nM verapamil by 2,8\%, compared to the initial tension maximum. Additionally, all tested measurement modes provide similar results while focusing on different analysis parameters. Conclusion: The CellDrum technology allows highly sensitive biomechanical stress measurements of cultured haSMC monolayers. The mechanical stress responses evoked by the application of vasoactive calcium channel modulators were quantified functionally (N/m²). All tested operation modes resulted in equal findings, whereas each mode features operation-related data analysis.},
  language  = {en}
}
@article{HasanKeilStaatetal.2012,
  author    = {Hasan, Istabrak and Keil, Ludger and Staat, Manfred and Wahl, Gerhard and Bourauel, Christoph},
  title     = {Determination of the frictional coefficient of the implant-antler interface : experimental approach},
  series = {Biomedical Engineering / Biomedizinische Technik},
  volume    = {57},
  journal   = {Biomedical Engineering / Biomedizinische Technik},
  number    = {5},
  publisher = {De Gruyter},
  address   = {Berlin},
  issn      = {1862-278X},
  pages     = {359 -- 363},
  year      = {2012},
  abstract  = {The similar bone structure of reindeer antler to human bone permits studying the osseointegration of dental implants in the jawbone. As the friction is one of the major factors that have a significant influence on the initial stability of immediately loaded dental implants, it is essential to define the frictional coefficient of the implant-antler interface. In this study, the kinetic frictional forces at the implant-antler interface were measured experimentally using an optomechanical setup and a stepping motor controller under different axial loads and sliding velocities. The corresponding mean values of the static and kinetic frictional coefficients were within the range of 0.5-0.7 and 0.3-0.5, respectively. An increase in the frictional forces with increasing applied axial loads was registered. The measurements showed an evidence of a decrease in the magnitude of the frictional coefficient with increasing sliding velocity. The results of this study provide a considerable assessment to clarify the suitable frictional coefficient to be used in the finite element contact analysis of antler specimens.},
  language  = {en}
}
@article{BassamHeschelerTemizArtmannetal.2012,
  author    = {Bassam, Rasha and Hescheler, J{\"u}rgen and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard and Digel, Ilya},
  title     = {Effects of spermine NONOate and ATP on the thermal stability of hemoglobin},
  series = {BMC Biophysics},
  volume    = {5},
  journal   = {BMC Biophysics},
  publisher = {BioMed Central},
  address   = {London},
  issn      = {2046-1682},
  doi       = {10.1186/2046-1682-5-16},
  year      = {2012},
  abstract  = {Background Minor changes in protein structure induced by small organic and inorganic molecules can result in significant metabolic effects. The effects can be even more profound if the molecular players are chemically active and present in the cell in considerable amounts. The aim of our study was to investigate effects of a nitric oxide donor (spermine NONOate), ATP and sodium/potassium environment on the dynamics of thermal unfolding of human hemoglobin (Hb). The effect of these molecules was examined by means of circular dichroism spectrometry (CD) in the temperature range between 25°C and 70°C. The alpha-helical content of buffered hemoglobin samples (0.1 mg/ml) was estimated via ellipticity change measurements at a heating rate of 1°C/min. Results Major results were: 1) spermine NONOate persistently decreased the hemoglobin unfolding temperature T u irrespectively of the Na + /K + environment, 2) ATP instead increased the unfolding temperature by 3°C in both sodium-based and potassium-based buffers and 3) mutual effects of ATP and NO were strongly influenced by particular buffer ionic compositions. Moreover, the presence of potassium facilitated a partial unfolding of alpha-helical structures even at room temperature. Conclusion The obtained data might shed more light on molecular mechanisms and biophysics involved in the regulation of protein activity by small solutes in the cell.},
  language  = {en}
}
@article{Grotendorst2012,
  author    = {Grotendorst, Johannes},
  title     = {IAS Winter School: Hierarchical Methods for Dynamics in Complex Molecular Systems},
  series = {Innovatives Supercomputing in Deutschland : inSiDE},
  volume    = {10},
  journal   = {Innovatives Supercomputing in Deutschland : inSiDE},
  pages     = {104 -- 1},
  year      = {2012},
  language  = {en}
}
@article{MansurovJandosovKerimkulovaetal.2014,
  author    = {Mansurov, Zulkhair A. and Jandosov, J. M. and Kerimkulova, Almagul R. and Azat, Seitkhan and Zhubanova, Azhar Achmet and Digel, Ilya and Savistkaya, I. S. and Akimbekov, Nuraly S. and Kistaubaeva, A. S.},
  title     = {Nanostructured carbon materials for biomedical use},
  series = {Eurasian chemico-technological journal : quarterly journal of the International Higher Education Academy of Sciences},
  volume    = {15 (2013)},
  journal   = {Eurasian chemico-technological journal : quarterly journal of the International Higher Education Academy of Sciences},
  number    = {3},
  publisher = {Institute of Combustion Problems},
  address   = {Almaty},
  issn      = {1562-3920},
  doi       = {10.18321/ectj224},
  pages     = {209 -- 217},
  year      = {2014},
  abstract  = {One of the priority trends of carbon nanotechnology is creation of nanocomposite systems. Such carbon nanostructured composites were produced using - raw materials based on the products of agricultural waste, such as grape stones, apricot stones, rice husk. These products have a - wide spectrum of application and can be obtained in large quantities. The Institute of Combustion Problems has carried out the work on synthesis of the nanostructured carbon sorbents for multiple applications including the field of biomedicine. The article presents the data on the synthesis and physico-chemical properties of carbonaceous sorbents using physicochemical methods of investigation: separation and purification of biomolecules; isolation of phytohormone - fusicoccin; adsorbent INGO-1 in the form of an adsorption column for blood detoxification, oral (entero) sorbent - INGO-2; the study of efferent and probiotic properties and sorption activity in regard to the lipopolysaccharide (LPS), new biocomposites - based on carbonized rice husk (CRH) and cellular microorganisms; the use of CRH in wound treatment. A new material for blood detoxication (INGO-1) has been obtained. Adsorption of p-cresyl sulfate and indoxyl sulfate has shown that active carbon adsorbent can remove clinically significant level of p-cresyl sulfate and indoxyl sulfate from human plasma. Enterosorbent INGO-2 possesses high adsorption activity in relation to Gram-negative bacteria and their endotoxins. INGO-2 slows down the growth of conditionally pathogenic microorganisms, without having a negative effect on bifido and lactobacteria. The use of enterosorbent INGO-2 for sorption therapy may provide a solution to a complex problem - detoxication of the digestive tract and normalization of the intestinal micro ecology. The immobilized probiotic called "Riso-lact" was registered at the Ministry of Health of the Republic of Kazakhstan as a biologically active food additive. The developed technology is patented and provides production of the medicine in the form of freeze-dried biomass immobilized in vials.},
  language  = {en}
}
@article{StaatVu2012,
  author    = {Staat, Manfred and Vu, Duc Khoi},
  title     = {Limit analysis of flaws in pressurized pipes and cylindrical vessels Part II: Circumferential defects},
  series = {Engineering Fracture Mechanic},
  volume    = {97},
  journal   = {Engineering Fracture Mechanic},
  number    = {1},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0013-7944},
  doi       = {10.1016/j.engfracmech.2012.05.017},
  pages     = {314 -- 333},
  year      = {2012},
  abstract  = {Upper and lower bound theorems of limit analyses have been presented in part I of the paper. Part II starts with the finite element discretization of these theorems and demonstrates how both can be combined in a primal-dual optimization problem. This recently proposed numerical method is used to guide the development of a new class of closed-form limit loads for circumferential defects, which show that only large defects contribute to plastic collapse with a rapid loss of strength with increasing crack sizes. The formulae are compared with primal-dual FEM limit analyses and with burst tests. Even closer predictions are obtained with iterative limit load solutions for the von Mises yield function and for the Tresca yield function. Pressure loading of the faces of interior cracks in thick pipes reduces the collapse load of circumferential defects more than for axial flaws. Axial defects have been treated in part I of the paper.},
  language  = {en}
}
@article{BrockhausBehbahaniMurisetal.2021,
  author    = {Brockhaus, Moritz K. and Behbahani, Mehdi and Muris, Farina and Jansen, Sebastian V. and Schmitz-Rode, Thomas and Steinseifer, Ulrich and Clauser, Johanna C.},
  title     = {In vitro thrombogenicity testing of pulsatile mechanical circulatory support systems: Design and proof-of-concept},
  series = {Artificial Organs},
  volume    = {45},
  journal   = {Artificial Organs},
  number    = {12},
  publisher = {Wiley},
  address   = {Weinheim},
  issn      = {1525-1594},
  doi       = {10.1111/aor.14046},
  pages     = {1513 -- 1521},
  year      = {2021},
  abstract  = {Thrombogenic complications are a main issue in mechanical circulatory support (MCS). There is no validated in vitro method available to quantitatively assess the thrombogenic performance of pulsatile MCS devices under realistic hemodynamic conditions. The aim of this study is to propose a method to evaluate the thrombogenic potential of new designs without the use of complex in-vivo trials. This study presents a novel in vitro method for reproducible thrombogenicity testing of pulsatile MCS systems using low molecular weight heparinized porcine blood. Blood parameters are continuously measured with full blood thromboelastometry (ROTEM; EXTEM, FIBTEM and a custom-made analysis HEPNATEM). Thrombus formation is optically observed after four hours of testing. The results of three experiments are presented each with two parallel loops. The area of thrombus formation inside the MCS device was reproducible. The implantation of a filter inside the loop catches embolizing thrombi without a measurable increase of platelet activation, allowing conclusions of the place of origin of thrombi inside the device. EXTEM and FIBTEM parameters such as clotting velocity (α) and maximum clot firmness (MCF) show a total decrease by around 6\% with a characteristic kink after 180 minutes. HEPNATEM α and MCF rise within the first 180 minutes indicate a continuously increasing activation level of coagulation. After 180 minutes, the consumption of clotting factors prevails, resulting in a decrease of α and MCF. With the designed mock loop and the presented protocol we are able to identify thrombogenic hot spots inside a pulsatile pump and characterize their thrombogenic potential.},
  language  = {en}
}
@article{StaeudleSeynnesLapsetal.2022,
  author    = {St{\"a}udle, Benjamin and Seynnes, Olivier and Laps, Guido and Br{\"u}ggemann, Gert-Peter and Albracht, Kirsten},
  title     = {Altered gastrocnemius contractile behavior in former achilles tendon rupture patients during walking},
  series = {Frontiers in Physiology},
  volume    = {13},
  journal   = {Frontiers in Physiology},
  publisher = {Frontiers Research Foundation},
  address   = {Lausanne},
  issn      = {1664-042X},
  doi       = {10.3389/fphys.2022.792576},
  pages     = {12 Seiten},
  year      = {2022},
  abstract  = {Achilles tendon rupture (ATR) remains associated with functional limitations years after injury. Architectural remodeling of the gastrocnemius medialis (GM) muscle is typically observed in the affected leg and may compensate force deficits caused by a longer tendon. Yet patients seem to retain functional limitations during—low-force—walking gait. To explore the potential limits imposed by the remodeled GM muscle-tendon unit (MTU) on walking gait, we examined the contractile behavior of muscle fascicles during the stance phase. In a cross-sectional design, we studied nine former patients (males; age: 45 ± 9 years; height: 180 ± 7 cm; weight: 83 ± 6 kg) with a history of complete unilateral ATR, approximately 4 years post-surgery. Using ultrasonography, GM tendon morphology, muscle architecture at rest, and fascicular behavior were assessed during walking at 1.5 m⋅s-1 on a treadmill. Walking patterns were recorded with a motion capture system. The unaffected leg served as control. Lower limbs kinematics were largely similar between legs during walking. Typical features of ATR-related MTU remodeling were observed during the stance sub-phases corresponding to series elastic element (SEE) lengthening (energy storage) and SEE shortening (energy release), with shorter GM fascicles (36 and 36\%, respectively) and greater pennation angles (8° and 12°, respectively). However, relative to the optimal fascicle length for force production, fascicles operated at comparable length in both legs. Similarly, when expressed relative to optimal fascicle length, fascicle contraction velocity was not different between sides, except at the time-point of peak series elastic element (SEE) length, where it was 39 ± 49\% lower in the affected leg. Concomitantly, fascicles rotation during contraction was greater in the affected leg during the whole stance-phase, and architectural gear ratios (AGR) was larger during SEE lengthening. Under the present testing conditions, former ATR patients had recovered a relatively symmetrical walking gait pattern. Differences in seen AGR seem to accommodate the profound changes in MTU architecture, limiting the required fascicle shortening velocity. Overall, the contractile behavior of the GM fascicles does not restrict length- or velocity-dependent force potentials during this locomotor task.},
  language  = {en}
}
@article{StaeudleSeynnesLapsetal.2021,
  author    = {St{\"a}udle, Benjamin and Seynnes, Olivier and Laps, Guido and G{\"o}ll, Fabian and Br{\"u}ggemann, Gert-Peter and Albracht, Kirsten},
  title     = {Recovery from achilles tendon repair: a combination of Postsurgery Outcomes and Insufficient remodeling of muscle and tendon},
  series = {Medicine \& Science in Sports \& Exercise},
  volume    = {53},
  journal   = {Medicine \& Science in Sports \& Exercise},
  number    = {7},
  publisher = {American College of Sports Medicine},
  address   = {Philadelphia, Pa.},
  issn      = {1530-0315},
  doi       = {10.1249/MSS.0000000000002592},
  pages     = {1356 -- 1366},
  year      = {2021},
  abstract  = {Achilles tendon rupture (ATR) patients have persistent functional deficits in the triceps surae muscle-tendon unit (MTU). The complex remodeling of the MTU accompanying these deficits remains poorly understood. The purpose of the present study was to associate in vivo and in silico data to investigate the relations between changes inMTU properties and strength deficits inATR patients. Methods: Elevenmale subjects who had undergone surgical repair of complete unilateral ATR were examined 4.6 ± 2.0 (mean ± SD) yr after rupture. Gastrocnemius medialis (GM) tendon stiffness, morphology, and muscle architecture were determined using ultrasonography. The force-length relation of the plantar flexor muscles was assessed at five ankle joint angles. In addition, simulations (OpenSim) of the GM MTU force-length properties were performed with various iterations of MTU properties found between the unaffected and the affected side. Results: The affected side of the patients displayed a longer, larger, and stiffer GM tendon (13\% ± 10\%, 105\% ± 28\%, and 54\% ± 24\%, respectively) compared with the unaffected side. The GM muscle fascicles of the affected side were shorter (32\% ± 12\%) and with greater pennation angles (31\% ± 26\%). A mean deficit in plantarflexion moment of 31\% ± 10\% was measured. Simulations indicate that pairing an intact muscle with a longer tendon shifts the optimal angular range of peak force outside physiological angular ranges, whereas the shorter muscle fascicles and tendon stiffening seen in the affected side decrease this shift, albeit incompletely. Conclusions: These results suggest that the substantial changes in MTU properties found in ATR patients may partly result from compensatory remodeling, although this process appears insufficient to fully restore muscle function.},
  language  = {en}
}
@article{KolditzAlbinAbeletal.2016,
  author    = {Kolditz, Melanie and Albin, Thivaharan and Abel, Dirk and Fasse, Alessandro and Br{\"u}ggemann, Gert-Peter and Albracht, Kirsten},
  title     = {Evaluation of foot position and orientation as manipulated variables to control external knee adduction moments in leg extension training},
  series = {Computer methods and programs in biomedicine},
  volume    = {171},
  journal   = {Computer methods and programs in biomedicine},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0169-2607},
  doi       = {10.1016/j.cmpb.2016.09.005},
  pages     = {81 -- 86},
  year      = {2016},
  abstract  = {Background and Objective Effective leg extension training at a leg press requires high forces, which need to be controlled to avoid training-induced damage. In order to avoid high external knee adduction moments, which are one reason for unphysiological loadings on knee joint structures, both training movements and the whole reaction force vector need to be observed. In this study, the applicability of lateral and medial changes in foot orientation and position as possible manipulated variables to control external knee adduction moments is investigated. As secondary parameters both the medio-lateral position of the center of pressure and the frontal-plane orientation of the reaction force vector are analyzed. Methods Knee adduction moments are estimated using a dynamic model of the musculoskeletal system together with the measured reaction force vector and the motion of the subject by solving the inverse kinematic and dynamic problem. Six different foot conditions with varying positions and orientations of the foot in a static leg press are evaluated and compared to a neutral foot position. Results Both lateral and medial wedges under the foot and medial and lateral shifts of the foot can influence external knee adduction moments in the presented study with six healthy subjects. Different effects are observed with the varying conditions: the pose of the leg is changed and the direction and center of pressure of the reaction force vector is influenced. Each effect results in a different direction or center of pressure of the reaction force vector. Conclusions The results allow the conclusion that foot position and orientation can be used as manipulated variables in a control loop to actively control knee adduction moments in leg extension training.},
  language  = {en}
}
@article{KaramanidisAlbrachtBraunsteinetal.2011,
  author    = {Karamanidis, Kiros and Albracht, Kirsten and Braunstein, Bjoern and Catala, Maria Moreno and Goldmann, Jan-Peter and Br{\"u}ggemann, Gert-Peter},
  title     = {Lower leg musculoskeletal geometry and sprint performance},
  series = {Gait and Posture},
  volume    = {34},
  journal   = {Gait and Posture},
  number    = {1},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0966-6362},
  doi       = {10.1016/j.gaitpost.2011.03.009},
  pages     = {138 -- 141},
  year      = {2011},
  abstract  = {The purpose of this study was to investigate whether sprint performance is related to lower leg musculoskeletal geometry within a homogeneous group of highly trained 100-m sprinters. Using a cluster analysis, eighteen male sprinters were divided into two groups based on their personal best (fast: N = 11, 10.30 ± 0.07 s; slow: N = 7, 10.70 ± 0.08 s). Calf muscular fascicle arrangement and Achilles tendon moment arms (calculated by the gradient of tendon excursion versus ankle joint angle) were analyzed for each athlete using ultrasonography. Achilles tendon moment arm, foot and ankle skeletal geometry, fascicle arrangement as well as the ratio of fascicle length to Achilles tendon moment arm showed no significant (p > 0.05) correlation with sprint performance, nor were there any differences in the analyzed musculoskeletal parameters between the fast and slow sprinter group. Our findings provide evidence that differences in sprint ability in world-class athletes are not a result of differences in the geometrical design of the lower leg even when considering both skeletal and muscular components.},
  language  = {en}
}
@article{KozhalakovaZhubanovaMansurovetal.2010,
  author    = {Kozhalakova, A. A. and Zhubanova, Azhar A. and Mansurov, Z. A. and Digel, Ilya and Tazhibayeva, S. M. and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l},
  title     = {Adsorption of bacterial lipopolysaccharides on carbonized rice shell},
  series = {Science of Central Asia},
  journal   = {Science of Central Asia},
  pages     = {50 -- 54},
  year      = {2010},
  language  = {en}
}
@article{BelavyAlbrachtBrueggemannetal.2016,
  author    = {Belavy, Daniel L. and Albracht, Kirsten and Br{\"u}ggemann, Gert-Peter and Vergroesen, Pieter-Paul A. and Dieen, Jaap H. van},
  title     = {Can exercise positively influence the intervertebral disc?},
  series = {Sports Medicine},
  volume    = {46},
  journal   = {Sports Medicine},
  number    = {4},
  publisher = {Springer},
  address   = {Berlin},
  issn      = {1179-2035},
  doi       = {10.1007/s40279-015-0444-2},
  pages     = {473 -- 485},
  year      = {2016},
  abstract  = {To better understand what kinds of sports and exercise could be beneficial for the intervertebral disc (IVD), we performed a review to synthesise the literature on IVD adaptation with loading and exercise. The state of the literature did not permit a systematic review; therefore, we performed a narrative review. The majority of the available data come from cell or whole-disc loading models and animal exercise models. However, some studies have examined the impact of specific sports on IVD degeneration in humans and acute exercise on disc size. Based on the data available in the literature, loading types that are likely beneficial to the IVD are dynamic, axial, at slow to moderate movement speeds, and of a magnitude experienced in walking and jogging. Static loading, torsional loading, flexion with compression, rapid loading, high-impact loading and explosive tasks are likely detrimental for the IVD. Reduced physical activity and disuse appear to be detrimental for the IVD. We also consider the impact of genetics and the likelihood of a 'critical period' for the effect of exercise in IVD development. The current review summarises the literature to increase awareness amongst exercise, rehabilitation and ergonomic professionals regarding IVD health and provides recommendations on future directions in research.},
  language  = {en}
}
@article{YangKriechbaumerAlbrachtetal.2014,
  author    = {Yang, Peng-Fei and Kriechbaumer, Andreas and Albracht, Kirsten and Sanno, Maximilian and Ganse, Bergita and Koy, Timmo and Shang, Peng and Br{\"u}ggemann, Gert-Peter and M{\"u}ller, Lars Peter and Rittweger, J{\"o}rn},
  title     = {A novel optical approach for assessing in vivo bone segment deformation and its application in muscle-bone relationship studies in humans},
  series = {Journal of Orthopaedic Translation},
  volume    = {2},
  journal   = {Journal of Orthopaedic Translation},
  number    = {4},
  publisher = {Elsevier},
  address   = {Singapore},
  issn      = {2214-0328},
  doi       = {10.1016/j.jot.2014.07.078},
  pages     = {238 -- 238},
  year      = {2014},
  language  = {en}
}
@article{LeimenaArtmannDachwaldetal.2010,
  author    = {Leimena, W. and Artmann, Gerhard and Dachwald, Bernd and Temiz Artmann, Ayseg{\"u}l and Gossmann, Matthias and Digel, Ilya},
  title     = {Feasibility of an in-situ microbial decontamination of an ice-melting probe},
  series = {Eurasian Chemico-Technological Journal},
  volume    = {12},
  journal   = {Eurasian Chemico-Technological Journal},
  number    = {2},
  publisher = {Institute of Combustion Problems},
  address   = {Almaty},
  isbn      = {1562-3920},
  doi       = {10.18321/ectj37},
  pages     = {145 -- 150},
  year      = {2010},
  abstract  = {Autonomous robotic systems for penetrating thick ice shells with simultaneous collecting of scientific data are very promising devices in both terrestrial (glacier, climate research) and extra-terrestrial applications. Technical challenges in development of such systems are numerous and include 3D-navigation, an appropriate energy source, motion control, etc. Not less important is the problem of forward contamination of the pristine glacial environments with microorganisms and biomolecules from the surface of the probe. This study was devoted to establishing a laboratory model for microbial contamination of a newly constructed ice-melting probe called IceMole and to analyse the viability and amount of the contaminating microorganisms as a function of distance. The used bacterial strains were Bacillus subtilis (ATCC 6051) and Escherichia coli (ATCC 11775). The main objective was development of an efficient and reliable in-situ decontamination method of the melting probe. Therefore, several chemical substances were tested in respect of their efficacy to eliminate bacteria on the surface of the melting probe at low temperature (0 - 5 °C) and at continuous dilution by melted water. Our study has shown that at least 99.9\% decontamination of the IceMole can be successfully achieved by the injection of 30\% (v/v) hydrogen peroxide and 3\% (v/v) sodium hypochlorite into the drilling site. We were able to reproduce this result in both time-dependent and depth-dependent experiments. The sufficient amount of 30\% (v/v) H₂O₂ or 3\% (v/v) NaClO has been found to be approximately 18 L per cm² of the probe's surface.},
  language  = {en}
}
@article{JansenBehbahaniLaumenetal.2010,
  author    = {Jansen, S. V. and Behbahani, Mehdi and Laumen, M. and Kaufmann, T. and Hormes, M. and Behr, M. and Schmitz-Rode, T. and Steinseifer, U.},
  title     = {Investigation of Steady Flow Through a Realistic Model of the Thoracic Human Aorta Using 3D Stereo PIV and CFD-Simulation},
  series = {ASAIO Journal},
  volume    = {56},
  journal   = {ASAIO Journal},
  number    = {2},
  publisher = {Lippincott Williams \& Wilkins},
  address   = {Philadelphia},
  doi       = {10.1097/01.mat.0000369377.65122.a3},
  pages     = {98},
  year      = {2010},
  language  = {en}
}
@article{BehbahaniNamWalugaetal.2010,
  author    = {Behbahani, Mehdi and Nam, J. and Waluga, C. and Behr, M. and Pasquali, M. and Mottaghy, K.},
  title     = {Modeling and Numerical Analysis of Platelet Activation, Adhesion and Aggregation in Artificial Organs},
  volume    = {56},
  number    = {2},
  publisher = {Lippincott Williams \& Wilkins},
  address   = {Philadelphia},
  doi       = {10.1097/01.mat.0000369377.65122.a3},
  pages     = {85},
  year      = {2010},
  language  = {en}
}
@article{BaroudWuBohneretal.2003,
  author    = {Baroud, Gamal and Wu, J.Z. and Bohner, M and Sponagel, Stefan and Steffen, T.},
  title     = {How to determine the permeability for cement infiltration into osteoporotic cancellous bone},
  series = {Medical Engineering \& Physics. 25 (2003), H. 4},
  journal   = {Medical Engineering \& Physics. 25 (2003), H. 4},
  issn      = {1350-4533},
  pages     = {283 -- 288},
  year      = {2003},
  abstract  = {Cement augmentation is an emerging surgical procedure in which bone cement is used to infiltrate and reinforce osteoporotic vertebrae. Although this infiltration procedure has been widely applied, it is performed empirically and little is known about the flow characteristics of cement during the injection process. We present a theoretical and experimental approach to investigate the intertrabecular bone permeability during the infiltration procedure. The cement permeability was considered to be dependent on time, bone porosity, and cement viscosity in our analysis. In order to determine the time-dependent permeability, ten cancellous bone cores were harvested from osteoporotic vertebrae, infiltrated with acrylic cement at a constant flow rate, and the pressure drop across the cores during the infiltration was measured. The viscosity dependence of the permeability was determined based on published experimental data. The theoretical model for the permeability as a function of bone porosity and time was then fit to the testing data. Our findings suggest that the intertrabecular bone permeability depends strongly on time. For instance, the initial permeability (60.89 mm4/N.s) reduced to approximately 63\% of its original value within 18 seconds. This study is the first to analyze cement flow through osteoporotic bone. The theoretical and experimental models provided in this paper are generic. Thus, they can be used to systematically study and optimize the infiltration process for clinical practice.},
  subject      = {Osteoporose},
  language  = {en}
}
@article{RhodenBallGrajewskietal.2023,
  author    = {Rhoden, Imke and Ball, Christopher Stephen and Grajewski, Matthias and Kuckshinrich, Wilhelm},
  title     = {Reverse engineering of stakeholder preferences - A multi-criteria assessment of the German passenger car sector},
  series = {Renewable and Sustainable Energy Reviews},
  volume    = {181},
  journal   = {Renewable and Sustainable Energy Reviews},
  number    = {July 2023},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1364-0321},
  doi       = {10.1016/j.rser.2023.113352},
  pages     = {Article number: 113352},
  year      = {2023},
  abstract  = {Germany is a frontrunner in setting frameworks for the transition to a low-carbon system. The mobility sector plays a significant role in this shift, affecting different people and groups on multiple levels. Without acceptance from these stakeholders, emission targets are out of reach. This research analyzes how the heterogeneous preferences of various stakeholders align with the transformation of the mobility sector, looking at the extent to which the German transformation paths are supported and where stakeholders are located. Under the research objective of comparing stakeholders' preferences to identify which car segments require additional support for a successful climate transition, a status quo of stakeholders and car performance criteria is the foundation for the analysis. Stakeholders' hidden preferences hinder the derivation of criteria weightings from stakeholders; therefore, a ranking from observed preferences is used. This study's inverse multi-criteria decision analysis means that weightings can be predicted and used together with a recalibrated performance matrix to explore future preferences toward car segments. Results show that stakeholders prefer medium-sized cars, with the trend pointing towards the increased potential for alternative propulsion technologies and electrified vehicles. These insights can guide the improved targeting of policy supporting the energy and mobility transformation. Additionally, the method proposed in this work can fully handle subjective approaches while incorporating a priori information. A software implementation of the proposed method completes this work and is made publicly available.},
  language  = {en}
}
@article{VoegeleJosyabhatlaBalletal.2023,
  author    = {V{\"o}gele, Stefan and Josyabhatla, Vishnu Teja and Ball, Christopher Stephen and Rhoden, Imke and Grajewski, Matthias and R{\"u}bbelke, Dirk and Kuckshinrichs, Wilhelm},
  title     = {Robust assessment of energy scenarios from stakeholders' perspectives},
  series = {Energy},
  journal   = {Energy},
  number    = {In Press, Article 128326},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1873-6785 (Online)},
  doi       = {10.1016/j.energy.2023.128326},
  year      = {2023},
  abstract  = {Using scenarios is vital in identifying and specifying measures for successfully transforming the energy system. Such transformations can be particularly challenging and require the support of a broader set of stakeholders. Otherwise, there will be opposition in the form of reluctance to adopt the necessary technologies. Usually, processes for considering stakeholders' perspectives are very time-consuming and costly. In particular, there are uncertainties about how to deal with modifications in the scenarios. In principle, new consulting processes will be required. In our study, we show how multi-criteria decision analysis can be used to analyze stakeholders' attitudes toward transition paths. Since stakeholders differ regarding their preferences and time horizons, we employ a multi-criteria decision analysis approach to identify which stakeholders will support or oppose a transition path. We provide a flexible template for analyzing stakeholder preferences toward transition paths. This flexibility comes from the fact that our multi-criteria decision aid-based approach does not involve intensive empirical work with stakeholders. Instead, it involves subjecting assumptions to robustness analysis, which can help identify options to influence stakeholders' attitudes toward transitions.},
  language  = {en}
}
@article{BehbahaniProbstMaietal.2010,
  author    = {Behbahani, Mehdi and Probst, M. and Mai, A. and Tran, L. and Vonderstein, K. and Keschenau, P. and Linde, T. and Steinseifer, U. and Behr, M. and Mottaghy, K.},
  title     = {The influence of high shear on thrombosis and hemolysis in artificial organs},
  series = {The International Journal of Artificial Organs},
  volume    = {33},
  journal   = {The International Journal of Artificial Organs},
  number    = {7},
  publisher = {Sage},
  address   = {Thousand Oaks},
  issn      = {0391-3988},
  pages     = {426 -- 426},
  year      = {2010},
  language  = {en}
}
@article{BallVoegeleGrajewskietal.2021,
  author    = {Ball, Christopher Stephen and V{\"o}gele, Stefan and Grajewski, Matthias and Kuckshinrichs, Wilhelm},
  title     = {E-mobility from a multi-actor point of view: Uncertainties and their impacts},
  series = {Technological Forecasting and Social Change},
  volume    = {170},
  journal   = {Technological Forecasting and Social Change},
  number    = {Art. 120925},
  publisher = {Elsevier},
  address   = {Amsterdam},
  isbn      = {0040-1625},
  doi       = {10.1016/j.techfore.2021.120925},
  year      = {2021},
  language  = {en}
}
@article{MiyamotoKanekoMatsuoetal.2010,
  author    = {Miyamoto, Ko-ichiro and Kaneko, Kazumi and Matsuo, Akira and Wagner, Torsten and Kanoh, Shin`ichiro and Sch{\"o}ning, Michael Josef and Yoshinobu, Tatsuo},
  title     = {Miniaturized chemical imaging sensor system using an OLED display panel},
  series = {Procedia Engineering},
  volume    = {5},
  journal   = {Procedia Engineering},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1877-7058},
  doi       = {10.1016/j.proeng.2010.09.160},
  pages     = {516 -- 519},
  year      = {2010},
  abstract  = {The chemical imaging sensor is a semiconductor-based chemical sensor that can visualize the two-dimensional distribution of specific ions or molecules in the solution. In this study, we developed a miniaturized chemical imaging sensor system with an OLED display panel as a light source that scans the sensor plate. In the proposed configuration, the display panel is placed directly below the sensor plate and illuminates the back surface. The measured area defined by illumination can be arbitrarily customized to fit the size and the shape of the sample to be measured. The waveform of the generated photocurrent, the currentvoltage characteristics and the pH sensitivity were investigated and pH imaging with this miniaturized system was demonstrated.},
  language  = {en}
}
@article{KirchnerOberlaenderFriedrichetal.2010,
  author    = {Kirchner, Patrick and Oberl{\"a}nder, Jan and Friedrich, Peter and Rysstad, Gunnar and Berger, J{\"o}rg and Keusgen, Michael and Sch{\"o}ning, Michael Josef},
  title     = {Realization of a calorimetric gas sensor on polyimide foil for applications in aseptic food industry},
  series = {Procedia Engineering},
  volume    = {5},
  journal   = {Procedia Engineering},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1877-7058},
  doi       = {10.1016/j.proeng.2010.09.098},
  pages     = {264 -- 267},
  year      = {2010},
  abstract  = {A calorimetric gas sensor is presented for the monitoring of gas-phase H2O2 at elevated temperature during sterilization processes in aseptic food industry. The sensor consists of two temperature-sensitive thin-film resistances built up on a polyimide foil with a thickness of 25 μm, which are passivated with a layer of SU-8 photo resist and catalytically activated with manganese(IV) oxide. Instead of an active heating structure, the calorimetric sensor utilizes the elevated temperature of an evaporated H2O2 aerosol. In an experimental set-up, the sensor has shown a sensitivity of 4.78 °C/(\%v/v) in a H2O2 concentration range of 0 to 10\% v/v at an evaporation temperature of 240 ∘C. Furthermore, the sensor possesses the same, unchanged sensor signal even at varied evaporation temperatures of the gas stream. The sensor characterization demonstrates the suitability of the calorimetric gas sensor for monitoring the efficiency of sterilization processes.},
  language  = {en}
}
@article{BohrnStuetzFleischeretal.2010,
  author    = {Bohrn, Ulrich and St{\"u}tz, Evamaria and Fleischer, Maximilian and Sch{\"o}ning, Michael Josef},
  title     = {Real-time detection of CO by eukaryotic cells},
  series = {Procedia Engineering},
  volume    = {5},
  journal   = {Procedia Engineering},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1877-7058},
  pages     = {17 -- 20},
  year      = {2010},
  abstract  = {In this contribution, we focus on the detection of toxic gases with living eukaryotic cells. A cell-based gas sensor system, able to measure the effects of direct exposure of gases to cells in real-time, was set up. Impedance data as well as oxygen consumption of Chinese hamster lung fibroblast cells (V79) were analysed upon exposure to carbon monoxide (CO). The CO (diluted in wet synthetic air) affects the cell respiration as indicated by an attenuated respiration signal after the CO exposure as well as an instant increase of the capacitive part of the impedance signal during the gas exposure.},
  language  = {en}
}
@article{SponagelBaroudFalketal.2004,
  author    = {Sponagel, Stefan and Baroud, Gamal and Falk, R. and Crookshank, M.},
  title     = {Experimental and theoretical investigation of directional permeability of human vertebral cancellous bone for cement infiltration. G. Baroud, R. Falk, M. Crookshank, S. Sponagel, T. Steffen},
  series = {Journal of Biomechanics. 37 (2004), H. 2},
  journal   = {Journal of Biomechanics. 37 (2004), H. 2},
  isbn      = {0021-9290},
  pages     = {189 -- 196},
  year      = {2004},
  language  = {en}
}
@article{SpelthahnSchaffrathCoppeetal.2010,
  author    = {Spelthahn, Heiko and Schaffrath, Sophie and Coppe, Thomas and Rufi, Frederic and Sch{\"o}ning, Michael Josef},
  title     = {Development of an electrolyte-insulator-semiconductor (EIS) based capacitive heavy metal sensor for the detection of Pb2+ und Cd2+ ions},
  series = {Physica status solidi (a) : applications and material science},
  volume    = {207},
  journal   = {Physica status solidi (a) : applications and material science},
  number    = {4},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1862-6300},
  doi       = {10.1002/pssa.200983306},
  pages     = {930 -- 934},
  year      = {2010},
  abstract  = {Chalcogenide glass materials as membranes for potentiometric sensors for chemical analysis in solutions have been studied since more than 20 years. In this work, an electrolyte-insulator-semiconductor structure was combined with chalcogenide glass membranes prepared by means of the pulsed laser deposition technique. Depending on the membrane composition a selectivity to different ions (Cd2+ and Pb2+) is achieved. The different sensor membranes have been physically characterised using microscopy, ellipsometry, profilometry, atomic force microscopy (AFM), scanning electron microscopy (SEM) and Rutherford backscattering spectrometry (RBS). The electrochemical behaviour has been investigated via capacitance/voltage (C/V) and constant capacitance (ConCap) measurements and results in a Cd2+ sensitivity of 23.1 ± 0.6 mV per decade in a linear range from 7 × 10-6 to 10-2 mol/l and 24.4 ± 0.5 mV per decade in a linear range from 5 × 10-6 to 10-2 mol/l for Pb2+, respectively.},
  language  = {en}
}
@article{DigelWehlitzKayseretal.2018,
  author    = {Digel, Ilya and Wehlitz, V. and Kayser, Peter and Figiel-Lange, A. and Bassam, Rasha and Rundstedt, F. von},
  title     = {Suspension depletion approach for exemption of infected Solanum jasminoides cells from pospiviroids},
  series = {Plant Pathology},
  volume    = {67},
  journal   = {Plant Pathology},
  number    = {2},
  publisher = {Wiley},
  address   = {Oxford},
  issn      = {1365-3059},
  doi       = {10.1111/ppa.12750},
  pages     = {358 -- 365},
  year      = {2018},
  abstract  = {Despite numerous studies, viroid elimination from infected plants remains a very challenging task. This study introduces for the first time a novel 'suspension depletion' approach for exemption of Solanum jasminoides plants from viroids. The proposed method implies initial establishment of suspension cultures of the infected plant cells. The suspended cells were then physically treated (mild thermotherapy, 33 °C), which presumably delayed the replication of the viroid. The viroid concentration in the treated biomass was monitored weekly using pospiviroid-specific PCR. After 10-12 weeks of continuous treatment, a sufficient decrease in viroid concentration was observed such that the infection became undetectable by PCR. The treated single cells then gave rise to microcolonies on a solid culture medium and the obtained viroid-negative clones were further promoted to regenerate into viroid-free plants. Three years of accumulated experimental data suggests feasibility, broad applicability, and good efficacy of the proposed approach.},
  language  = {en}
}
@article{StaatBaroudTopcuetal.2008,
  author    = {Staat, Manfred and Baroud, Gamal and Topcu, M. and Sponagel, Stefan},
  title     = {Soft Materials in Technology and Biology - Characteristics, Properties, and Parameter Identification},
  series = {Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.)},
  journal   = {Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.)},
  publisher = {Springer},
  address   = {Berlin},
  isbn      = {978-3-540-75408-4},
  pages     = {253 -- 315},
  year      = {2008},
  language  = {en}
}
@article{TemizArtmannBaşkurtPekcetinetal.2000,
  author    = {Temiz Artmann, Ayseg{\"u}l and Ba{\c{s}}kurt, Oǧuz Kerim and Pekcetin, C. and Kandemir, F.},
  title     = {Leukocyte activation, oxidant stress and red blood cell properties after acute, exhausting exercise in rats. Temiz, A.; Baskurt, O. K., Pekcetin, C.; Kandemir, F.; G{\"u}re, A.},
  series = {Clinical Hemorheology and Microcirculation. 22 (2000), H. 4},
  journal   = {Clinical Hemorheology and Microcirculation. 22 (2000), H. 4},
  isbn      = {1386-0291},
  pages     = {253 -- 259},
  year      = {2000},
  language  = {en}
}
@article{TemizArtmannYalcinResmietal.2002,
  author    = {Temiz Artmann, Ayseg{\"u}l and Yalcin, Ozlem and Resmi, Halil and Ba{\c{s}}kurt, Oǧuz Kerim},
  title     = {Can white blood cell activation be one of the major factors that affect hemorheological parameters during and after exercise?},
  series = {Clinical Hemorheology and Microcirculation. 26 (2002), H. 3},
  journal   = {Clinical Hemorheology and Microcirculation. 26 (2002), H. 3},
  isbn      = {1386-0291},
  pages     = {189 -- 193},
  year      = {2002},
  language  = {en}
}
@article{GerhardsBelloumBerretzetal.2010,
  author    = {Gerhards, Michael and Belloum, Adam and Berretz, Frank and Sander, Volker and Skorupa, Sascha},
  title     = {A history-tracing XML-based provenance framework for workflows},
  series = {The 5th Workshop on Workflows in Support of Large-Scale Science},
  journal   = {The 5th Workshop on Workflows in Support of Large-Scale Science},
  publisher = {IEEE},
  address   = {New York},
  isbn      = {978-1-4244-8989-3},
  doi       = {10.1109/WORKS.2010.5671873},
  pages     = {10 Seiten},
  year      = {2010},
  abstract  = {The importance of validating and reproducing the outcome of computational processes is fundamental to many application domains. Assuring the provenance of workflows will likely become even more important with respect to the incorporation of human tasks to standard workflows by emerging standards such as WS-HumanTask. This paper addresses this trend by an actor-based workflow approach that actively support provenance. It proposes a framework to track and store provenance information automatically that applies for various workflow management systems. In particular, the introduced provenance framework supports the documentation of workflows in a legally binding way. The authors therefore use the concept of layered XML documents, i.e. history-tracing XML. Furthermore, the proposed provenance framework enables the executors (actors) of a particular workflow task to attest their operations and the associated results by integrating digital XML signatures.},
  language  = {en}
}
@article{SponagelBaroudFalketal.2004,
  author    = {Sponagel, Stefan and Baroud, Gamal and Falk, R. and Crookshank, M.},
  title     = {Corrigendum to "Experimental and theoretical investigation of directional permeability of human vertebral cancellous bone for cement infiltration". Baroud, G.; Falk, R.; Crookshank, M.; Sponagel, S.; Steffen, T.},
  series = {Journal of Biomechanics. 37 (2004), H. 2},
  journal   = {Journal of Biomechanics. 37 (2004), H. 2},
  isbn      = {0021-9290},
  pages     = {1802},
  year      = {2004},
  language  = {en}
}
@article{TemizArtmannBaşkurtEdremitlioglu1994,
  author    = {Temiz Artmann, Ayseg{\"u}l and Ba{\c{s}}kurt, Oǧuz Kerim and Edremitlioglu, M.},
  title     = {In vitro effects of in vivo activated leukocytes on red blood cell filterability and lipid peroxidation. Baskurt, O.K.; Edremitlioglu, M.; Temiz, A.},
  series = {Clinical Hemorheology. 14 (1994), H. 4},
  journal   = {Clinical Hemorheology. 14 (1994), H. 4},
  pages     = {591 -- 596},
  year      = {1994},
  language  = {en}
}
@article{SponagelBaroudSteffenetal.2002,
  author    = {Sponagel, Stefan and Baroud, Gamal and Steffen, T. and Wu, J.},
  title     = {Parameter identification for cement infiltration of osteoporotic bone},
  series = {Poromechanics II : Proceedings of the Second Biot Conference on Poromechanics Grenoble, France 26 - 28 August 2002 / ed. by J.-L. Auriault ...},
  journal   = {Poromechanics II : Proceedings of the Second Biot Conference on Poromechanics Grenoble, France 26 - 28 August 2002 / ed. by J.-L. Auriault ...},
  publisher = {Balkema},
  address   = {Lisse [u.a.]},
  isbn      = {90-5809-394-8},
  pages     = {55 -- 58},
  year      = {2002},
  language  = {en}
}
@article{TemizArtmannBaşkurtMeiselman1998,
  author    = {Temiz Artmann, Ayseg{\"u}l and Ba{\c{s}}kurt, Oǧuz Kerim and Meiselman, H. J.},
  title     = {Effect of superoxide anions on red blood cell rheologic properties. Baskurt, O. K.; Temiz, A.; Meiselman, H. J.},
  series = {Free Radical Biology and Medicine. 24 (1998), H. 1},
  journal   = {Free Radical Biology and Medicine. 24 (1998), H. 1},
  isbn      = {0891-5849},
  pages     = {102 -- 110},
  year      = {1998},
  language  = {en}
}
@article{TemizArtmannBaşkurtMeiselman1997,
  author    = {Temiz Artmann, Ayseg{\"u}l and Ba{\c{s}}kurt, Oǧuz Kerim and Meiselman, H. J.},
  title     = {Red blood cell aggregation in experimental sepsis . Baskurt, O. K.; Temiz, A.; Meiselman, H. J.},
  series = {Journal of Laboratory and Clinical Medicine. 130 (1997), H. 2},
  journal   = {Journal of Laboratory and Clinical Medicine. 130 (1997), H. 2},
  isbn      = {0022-2143},
  pages     = {183 -- 190},
  year      = {1997},
  language  = {en}
}
@article{TemizArtmannBaşkurtEdremitlioglu1995,
  author    = {Temiz Artmann, Ayseg{\"u}l and Ba{\c{s}}kurt, Oǧuz Kerim and Edremitlioglu, M.},
  title     = {Effect of erythrocyte deformability on myocardial hematocrit gradient. Baskurt, O.K.; Edremitlioglu, M.; Temiz, A.},
  series = {American Journal of Physiology: Heart and Circulatory Physiology. 268 (1995), H. 1},
  journal   = {American Journal of Physiology: Heart and Circulatory Physiology. 268 (1995), H. 1},
  isbn      = {0363-6135},
  pages     = {260 -- 264},
  year      = {1995},
  language  = {en}
}
@article{WagnerMiyamotoSchoeningetal.2010,
  author    = {Wagner, Torsten and Miyamoto, Ko-ichiro and Sch{\"o}ning, Michael Josef and Yoshinobu, Tatsuo},
  title     = {Novel combination of digital light processing (DLP) and light-addressable potentiometric sensors (LAPS) for flexible chemical imaging},
  series = {Procedia Engineering},
  volume    = {5},
  journal   = {Procedia Engineering},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1877-7058},
  doi       = {10.1016/j.proeng.2010.09.161},
  pages     = {520 -- 523},
  year      = {2010},
  abstract  = {Chemical imaging systems allow the visualisation of the distribution of chemical species on the sensor surface. This work represents a new flexible approach of read out in a light-addressable potentiometric sensor (LAPS) with the help of a digital light processing (DLP) set-up. The DLP, known well for video projectors, consists of a mirror-array MEMS device which allows fast and flexible generation of light patterns. With the help of these light patterns the sensor surface of the LAPS device can be read out sequentially in a raster like scheme (scanning LAPS). The DLP approach has several advantages compared to conventional scanning LAPS set-ups, e.g., the spot size, the shape and the intensity of the light pointer can be changed easily and no mechanical movement is necessary, which reduces the size of the set-up and increases the stability and speed of measurement.},
  language  = {en}
}
@article{AbouzarPedrazaSchoeningetal.2010,
  author    = {Abouzar, Maryam H. and Pedraza, A. M. and Sch{\"o}ning, Michael Josef and Poghossian, Arshak},
  title     = {Label-free DNA hybridization and denaturation detection by means of field-effect nanoplate SOI capacitors functionalized with gold nanoparticles},
  series = {Procedia Engineering},
  volume    = {5},
  journal   = {Procedia Engineering},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1877-7058},
  doi       = {10.1016/j.proeng.2010.09.259},
  pages     = {918 -- 921},
  year      = {2010},
  abstract  = {A new approach for a label-free electrical detection of DNA hybridization and denaturation using an array of individually addressable field-effect nanoplate SOI (silicon-on-insulator) capacitors functionalized with gold nanoparticles is presented. By using a constant-capacitance measuring setup in a differential mode, signal changes of ∼110 mV and ∼70 mV have been registered after the DNA hybridization and denaturation events, respectively.},
  language  = {en}
}
@article{BerretzSkorupaSanderetal.2010,
  author    = {Berretz, Frank and Skorupa, Sascha and Sander, Volker and Belloum, Adam},
  title     = {Towards an actor-driven workflow management system for grids},
  series = {Proceedings of 2010 International Symposium on Collaborative Technologies and Systems},
  journal   = {Proceedings of 2010 International Symposium on Collaborative Technologies and Systems},
  publisher = {IEEE},
  address   = {Piscataway, NJ},
  isbn      = {978-1-4244-6619-1},
  doi       = {10.1109/CTS.2010.5478458},
  pages     = {611 -- 616},
  year      = {2010},
  abstract  = {Currently, most workflow management systems in Grid environments provide push-oriented job distribution strategies, where jobs are explicitly delegated to resources. In those scenarios the dedicated resources execute submitted jobs according to the request of a workflow engine or Grid wide scheduler. This approach has various limitations, particularly if human interactions should be integrated in workflow execution. To support human interactions with the benefit of enabling inter organizational computation and community approaches, this poster paper proposes the idea of a pull-based task distribution strategy. Here, heterogeneous resources, including human interaction, should actively select tasks for execution from a central repository. This leads to special demands regarding security issues like access control. In the established push-based job execution the resources are responsible for granting access to workflows and job initiators. In general this is done by access control lists, where users are explicitly mapped to local accounts according to their policies. In the pull-based approach the resources actively apply for job executions by sending requests to a central task repository. This means that every resource has to be able to authenticate against the repository to be authorized for task execution. In other words the authorization is relocated from the resources to the repository. The poster paper introduces current work regarding to the mentioned security aspects in the pull-based approach within the scope of the project "HiX4AGWS".},
  language  = {en}
}
@article{ZiemonsHeinrichsStreunetal.2004,
  author    = {Ziemons, Karl and Heinrichs, U. and Streun, M. and Pietrzyk, Uwe},
  title     = {Validation of GEANT3 simulation studies with a dual-head PMT ClearPET™ prototype},
  series = {2003 IEEE Nuclear Science Symposium Conference Record, Vol. 5},
  journal   = {2003 IEEE Nuclear Science Symposium Conference Record, Vol. 5},
  issn      = {1082-3654},
  pages     = {3053 -- 3056},
  year      = {2004},
  abstract  = {The ClearPET™ project is proposed by working groups of the Crystal Clear Collaboration (CCC) to develop a 2nd generation high performance small animal positron emission tomograph (PET). High sensitivity and high spatial resolution is foreseen for the ClearPET™ camera by using a phoswich arrangement combining mixed lutetium yttrium aluminum perovskite (LuYAP:Ce) and lutetium oxyorthosilicate (LSO) scintillating crystals. Design optimizations for the first photomultiplier tube (PMT) based ClearPET camera are done with a Monte-Carlo simulation package implemented on GEANT3 (CERN, Geneva, Switzerland). A dual-head prototype has been built to test the frontend electronics and was used to validate the implementation of the GEANT3 simulation tool. Multiple simulations were performed following the experimental protocols to measure the intrinsic resolution and the sensitivity profile in axial and radial direction. Including a mean energy resolution of about 27.0\% the simulated intrinsic resolution is about (1.41±0.11)mm compared to the measured of (1.48±0.06)mm. The simulated sensitivity profiles show a mean square deviation of 12.6\% in axial direction and 3.6\% in radial direction. Satisfactorily these results are representative for all designs and confirm the scanner geometry.},
  language  = {en}
}
@article{KhodaverdiChatziioannouWeberetal.2005,
  author    = {Khodaverdi, M. and Chatziioannou, A. F. and Weber, S. and Ziemons, Karl and Halling, H. and Pietrzyk, Uwe},
  title     = {Investigation of different MicroCT scanner configurations by GEANT4 simulations},
  series = {IEEE Transactions on Nuclear Science},
  volume    = {52},
  journal   = {IEEE Transactions on Nuclear Science},
  number    = {1},
  isbn      = {0018-9499},
  pages     = {188 -- 192},
  year      = {2005},
  abstract  = {This study has been performed to design the combination of the new ClearPET (ClearPET is a trademark of the Crystal Clear Collaboration), a small animal positron emission tomography (PET) system, with a micro-computed tomography (microCT) scanner. The properties of different microCT systems have been determined by simulations based on GEANT4. We will demonstrate the influence of the detector material and the X-ray spectrum on the obtained contrast. Four different detector materials (selenium, cadmium zinc telluride, cesium iodide and gadolinium oxysulfide) and two X-ray spectra (a molybdenum and a tungsten source) have been considered. The spectra have also been modified by aluminum filters of varying thickness. The contrast between different tissue types (water, air, brain, bone and fat) has been simulated by using a suitable phantom. The results indicate the possibility to improve the image contrast in microCT by an optimized combination of the X-ray source and detector material.},
  language  = {en}
}
@article{ZiemonsBruyndonckxPerezetal.2008,
  author    = {Ziemons, Karl and Bruyndonckx, P. and Perez, J. M. and Pietrzyk, Uwe and Rato, P. and Tavernier, S.},
  title     = {Beyond ClearPET: Next Aims},
  series = {5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro Symposium Proceedings ISBI 2008},
  journal   = {5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro Symposium Proceedings ISBI 2008},
  isbn      = {978-1-4244-2003-2},
  pages     = {1421 -- 1424},
  year      = {2008},
  abstract  = {The CRYSTAL CLEAR collaboration, in short CCC, is a consortium of 12 academic institutions, mainly from Europe, joining efforts in the area of developing instrumentation for nuclear medicine and medical imaging. In the framework of the CCC a high performance small animal PET system, called ClearPET, was developed by using new technologies in electronics and crystals in a phoswich arrangement combining two types of lutetium- based scintillator materials: LSO:Ce and LuYAP:Ce. Our next aim will be the development of hybrid image systems. Hybrid MR-PET imaging has many unique advantages for brain research. This has sparked a new research line within CCC for the development of novel MR-PET compatible technologies. MRI is not as sensitive as PET but PET has poorer spatial resolution than MRI. Two major advantages of PET are sensitivity and its ability to acquire metabolic information. To assess these innovations, the development of a 9.4T hybrid animal MR-PET scanner is proposed based on an existing 9.4T MR scanner that will be adapted to enable simultaneous acquisition of MR and PET data using cutting- edge technology for both MR and PET.},
  language  = {en}
}
@article{KhodaverdiChaziioannouWeberetal.2004,
  author    = {Khodaverdi, M. and Chaziioannou, A. F. and Weber, S. and Ziemons, Karl and Halling, H. and Pietrzyk, Uwe},
  title     = {Investigation of different microCT scanner configurations by GEANT4 simulations},
  series = {2003 IEEE Nuclear Science Symposium Conference Record, Vol. 4},
  journal   = {2003 IEEE Nuclear Science Symposium Conference Record, Vol. 4},
  issn      = {1082-3654},
  pages     = {2989 -- 2993},
  year      = {2004},
  abstract  = {This study has been performed to design the combination of the new ClearPET TM (ClearPET is a trademark of the Crystal Clear Collaboration), a small animal Positron Emission Tomography (PET) system, with a microComputed Tomography (microCT) scanner. The properties of different microCT systems have been determined by simulations based on GEANT4. We demonstrate the influence of the detector material and the X-ray spectrum on the obtained contrast. Four different detector materials (selenium, cadmium zinc telluride, cesium iodide and gadolinium oxysulfide) and two X-ray spectra (a molybdenum and a tungsten source) have been considered. The spectra have also been modified by aluminum filters of varying thickness. The contrast between different tissue types (water, air, brain, bone and fat) has been simulated by using a suitable phantom. The results indicate the possibility to improve the image contrast in microCT by an optimized combination of the X-ray source and detector material.},
  language  = {en}
}
@article{WagnerWernerMiyamotoetal.2010,
  author    = {Wagner, Torsten and Werner, Frederik and Miyamoto, Ko-ichiro and Ackermann, Hans-Josef and Yoshinobu, Tatsuo and Sch{\"o}ning, Michael Josef},
  title     = {FPGA-based LAPS device for the flexible design of sensing sites on functional interfaces},
  series = {Physica Status Solidi (A)},
  volume    = {207},
  journal   = {Physica Status Solidi (A)},
  number    = {4},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1862-6300},
  doi       = {10.1002/pssa.200983320},
  pages     = {844 -- 849},
  year      = {2010},
  abstract  = {The development of new interfaces for (bio-)chemical sensors requires comprehensive analyses and testing. The light-addressable potentiometric sensor (LAPS) can be used as a platform to investigate the sensitivity of a newly developed interface towards (bio-)chemical agents. LAPS measurements are spatially resolved by utilisation of focused light beams to define individual measurement spots. In this work, a new digitally modulated LAPS set-up based on an FPGA design will be introduced to increase the number of measurement spots, to shorten the measurement time and to improve the measurement accuracy.},
  language  = {en}
}
@article{BerretzSkorupaSanderetal.2011,
  author    = {Berretz, Frank and Skorupa, Sascha and Sander, Volker and Belloum, Adam and Bubak, Marian},
  title     = {Actor-Driven Workflow Execution in Distributed Environments},
  series = {Euro-Par 2010 Parallel Processing Workshops : HeteroPAR, HPCC, HiBB, CoreGrid, UCHPC, HPCF, PROPER, CCPI, VHPC ; Ischia, Italy, August 31 - September 3, 2010 ; revised selected papers / Mario R. Guarracino ... (eds.)},
  journal   = {Euro-Par 2010 Parallel Processing Workshops : HeteroPAR, HPCC, HiBB, CoreGrid, UCHPC, HPCF, PROPER, CCPI, VHPC ; Ischia, Italy, August 31 - September 3, 2010 ; revised selected papers / Mario R. Guarracino ... (eds.)},
  publisher = {Springer},
  address   = {Berlin},
  isbn      = {978-3-642-21877-4},
  pages     = {287 -- 294},
  year      = {2011},
  language  = {en}
}
@article{GerhardsSkorupaSanderetal.2011,
  author    = {Gerhards, M. and Skorupa, Sascha and Sander, Volker and Pfeiffer, P. and Belloum, Adam},
  title     = {Towards a security framework for a WS-HumanTask processor},
  series = {7th International Conference on Network and Service Management (CNSM), 2011 Paris},
  journal   = {7th International Conference on Network and Service Management (CNSM), 2011 Paris},
  publisher = {IEEE},
  address   = {New York},
  isbn      = {978-3-901882-44-9},
  pages     = {1 -- 5},
  year      = {2011},
  language  = {en}
}
@article{GerhardsSkorupaSanderetal.2011,
  author    = {Gerhards, M. and Skorupa, Sascha and Sander, Volker and Belloum, Adam and Vesunin, D. and Benabdelkader, A.},
  title     = {HisT/PLIER : A Two-Fold Provenance Approach for Grid-Enabled Scientific Workflows Using WS-VLAM},
  series = {12th IEEE/ACM International Conference on Grid Computing (GRID), 2011},
  journal   = {12th IEEE/ACM International Conference on Grid Computing (GRID), 2011},
  publisher = {IEEE},
  address   = {New York},
  doi       = {10.1109/Grid.2011.39},
  pages     = {224 -- 225},
  year      = {2011},
  language  = {en}
}
@article{HirschfeldLustfeldReisseletal.2010,
  author    = {Hirschfeld, Julian A. and Lustfeld, Hans and Reißel, Martin and Steffen, Bernhard},
  title     = {A novel scheme for precise diagnostics and effective stabilization of currents in a fuel cell stack},
  series = {International Journal of Energy Research},
  volume    = {34},
  journal   = {International Journal of Energy Research},
  number    = {3},
  publisher = {Wiley},
  address   = {London},
  issn      = {0363-907X},
  doi       = {10.1002/er.1662},
  pages     = {293 -- 301},
  year      = {2010},
  abstract  = {A novel scheme for detecting inhomogeneous internal currents in a fuel cell stack is presented. In this paper the scheme is investigated for the case that the flow field plates consist of graphite. Then plates of high conductivity, e.g. aluminium between the flow field plates together with small slits in these plates have three effects: (a) Whenever a local inhomogeneity of the electric current occurs at a particular cell in the stack, this will induce a surface current close to that cell perpendicular to the averaged current. This current can be detected. (b) The plates of high conductivity completely prevent the inhomogeneities from spreading to neighbouring cells. (c) Even at the particular cell the inhomogeneity is suppressed as far as possible. Thus this scheme leads to much better diagnostic possibilities and at the same time reduces electric instabilities to an extent, where they probably become harmless. This scheme will first be explained for a simple model to clarify the idea. However, very precise three dimensional computations using realistic parameters are presented, corroborating the results of the simple model.},
  language  = {en}
}
@article{HirschfeldLustfeldReisseletal.2010,
  author    = {Hirschfeld, Julian A. and Lustfeld, Hans and Reißel, Martin and Steffen, Bernhard},
  title     = {Tomographic diagnostics of current distributions in a fuel cell stack},
  series = {International Journal of Energy Research},
  volume    = {34},
  journal   = {International Journal of Energy Research},
  number    = {3},
  publisher = {Wiley},
  address   = {London},
  issn      = {0363-907X},
  doi       = {10.1002/er.1634},
  pages     = {284 -- 292},
  year      = {2010},
  abstract  = {A novel tomographic scheme for analysing the state of any single membrane electrode assembly (MEA) in a stack is suggested. Plates of very high conductivity placed between every fuel cell and slitted in an appropriate manner cause surface currents at well-defined locations of the stack. We show that knowing these surface currents, information about anomalies of the currents in a MEA can be obtained using the methods of tomography. The results are mathematically not unique. However, when assuming plausible defect structures, one can exclude improbable deficiencies by applying a special form of simulated annealing. We present numerical calculations of typical examples demonstrating that the essential defects of the MEA in any single cell of the stack can be detected and their extent can be determined.},
  language  = {en}
}
@article{HeinrichsPietrzykZiemons2003,
  author    = {Heinrichs, U. and Pietrzyk, Uwe and Ziemons, Karl},
  title     = {Design optimization of the PMT-ClearPET prototypes based on simulation studies with GEANT3},
  series = {IEEE Transactions on Nuclear Science},
  volume    = {50},
  journal   = {IEEE Transactions on Nuclear Science},
  number    = {5},
  isbn      = {0018-9499},
  pages     = {1428 -- 1432},
  year      = {2003},
  abstract  = {Within the Crystal Clear Collaboration (CCC), four centers are developing second generation high performance small animal positron emission tomography (PET) scanners for different kinds of animals and medical applications. The first prototypes are photomultiplier tube (PMT)-based systems including depth of interaction (DOI) detection by using a phoswich layer of lutetium oxyorthosilicate (LSO) and lutetium yttrium aluminum perovskite (LuYAP). The aim of these simulation studies is to optimize sensitivity and spatial resolution of given designs, which vary in fields of view (FOVs) caused by different detector configurations (ring/octagon) and sizes. For this purpose the simulation tool GEANT3 (CERN, Geneva, Switzerland) was used.},
  language  = {en}
}
@article{MuellerHirschfeldLambertzetal.2014,
  author    = {M{\"u}ller, Martin and Hirschfeld, Julian A. and Lambertz, Rita and Schulze Lohoff, Andreas and Lustfeld, Hans and Pfeifer, Heinz and Reißel, Martin},
  title     = {Validation of a novel method for detecting and stabilizing malfunctioning areas in fuel cell stacks},
  series = {Journal of power sources},
  volume    = {272},
  journal   = {Journal of power sources},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1873-2755 (E-Journal); 0378-7753 (Print)},
  doi       = {10.1016/j.jpowsour.2014.08.045},
  pages     = {225 -- 232},
  year      = {2014},
  abstract  = {In this paper a setup for detecting malfunctioning areas of MEAs in fuel cell stacks is described. Malfunctioning areas generate electric cross currents inside bipolar plates. To exploit this we suggest bipolar plates consisting not of two but of three layers. The third one is a highly conducting layer and segmented such that the cross currents move along the segments to the surface of the stack where they can be measured by an inductive sensor. With this information a realistic model can be used to detect the malfunctioning area. Furthermore the third layer will prevent any current inhomogeneity of a malfunctioning cell to spread to neighbouring cells in the stack. In this work the results of measurements in a realistic cell setup will be compared with the results obtained in simulation studies with the same configuration. The basis for the comparison is the reliable characterisation of the electrical properties of the cell components and the implication of these results into the simulation model. The experimental studies will also show the limits in the maximum number of segments, which can be used for a reliable detection of cross currents.},
  language  = {en}
}
@article{ReisselLustfeldHirschfeldetal.2009,
  author    = {Reißel, Martin and Lustfeld, Hans and Hirschfeld, Julian A. and Steffen, Bernhard},
  title     = {Uniqueness of magnetotomography for fuel cells and fuel cell stacks / Lustfeld, H. ; Hirschfeld, J. ; Reißel, M ; Steffen, B.},
  series = {Journal of Physics A: Mathematical and Theoretical. 42 (2009), H. 495205},
  journal   = {Journal of Physics A: Mathematical and Theoretical. 42 (2009), H. 495205},
  isbn      = {0022-3689},
  pages     = {9 S.},
  year      = {2009},
  language  = {en}
}
@article{ReisselLustfeldSteffenetal.2009,
  author    = {Reißel, Martin and Lustfeld, Hans and Steffen, Bernhard and Schmidt, U.},
  title     = {Reconstruction of Electric Currents in a Fuel Cell by Magnetic Field Measurements / Lustfeld, H. ; Reißel, M. ; Steffen, B. ; Schmidt, U.},
  series = {Journal of fuel cell science and technology},
  volume    = {Vol. 6},
  journal   = {Journal of fuel cell science and technology},
  number    = {Iss. 2},
  isbn      = {1550-624X},
  pages     = {021012-1 -- 021012-8},
  year      = {2009},
  language  = {en}
}
@article{ReisselHirschfeldLustfeldetal.2009,
  author    = {Reißel, Martin and Hirschfeld, Julian A. and Lustfeld, Hans and Steffen, Bernhard},
  title     = {Magnetotomography and Electric Currents in a Fuel Cell / Lustfeld, H. ; Reißel, M. ; Steffen, B.},
  series = {Fuel Cells. 9 (2009), H. 4},
  journal   = {Fuel Cells. 9 (2009), H. 4},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  isbn      = {1615-6854},
  pages     = {474 -- 481},
  year      = {2009},
  language  = {en}
}
@article{LustfeldHirschfeldReisseletal.2011,
  author    = {Lustfeld, Hans and Hirschfeld, Julian A. and Reißel, Martin and Steffen, Bernhard},
  title     = {Enhancement of precision and reduction of measuring points in tomographic reconstructions},
  series = {Physics Letters A},
  volume    = {375},
  journal   = {Physics Letters A},
  number    = {8},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0375-9601},
  pages     = {1167 -- 1171},
  year      = {2011},
  language  = {en}
}
@article{LustfeldPithanReissel2012,
  author    = {Lustfeld, Hans and Pithan, C. and Reißel, Martin},
  title     = {Metallic electrolyte composites in the framework of the brick-layer model},
  series = {Journal of the European Ceramic Society},
  volume    = {32},
  journal   = {Journal of the European Ceramic Society},
  number    = {4},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0955-2219},
  doi       = {10.1016/j.jeurceramsoc.2011.10.017},
  pages     = {859 -- 864},
  year      = {2012},
  abstract  = {It is well known that the already large dielectric constants of some electrolytes like BaTiO₃ can be enhanced further by adding metallic (e.g. Ni, Cu or Ag) nanoparticles. The enhancement can be quite large, a factor of more than 1000 is possible. The consequences for the properties will be discussed in the present paper applying a brick-layer model (BLM) for calculating dc-resistivities of thin layers and a modified one (PBLM) that includes percolation for calculating dielectric properties of these materials. The PBLM results in an at least qualitative description and understanding of the physical phenomena: This model gives an explanation for the steep increase of the dielectric constant below the percolation threshold and why this increase is connected to a dramatic decrease of the breakdown voltage as well as the ability of storing electrical energy. We conclude that metallic electrolyte composites like BaTiO₃ are not appropriate for energy storage.},
  language  = {en}
}