@article{ValeroChansonBung2020, author = {Valero, Daniel and Chanson, Hubert and Bung, Daniel Bernhard}, title = {Robust estimators for free surface turbulence characterization: A stepped spillway application}, series = {Flow Measurement and Instrumentation}, volume = {76}, journal = {Flow Measurement and Instrumentation}, number = {Art. 101809}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0955-5986}, doi = {10.1016/j.flowmeasinst.2020.101809}, year = {2020}, abstract = {Robust estimators are parameters insensitive to the presence of outliers. However, they presume the shape of the variables' probability density function. This study exemplifies the sensitivity of turbulent quantities to the use of classic and robust estimators and the presence of outliers in turbulent flow depth time series. A wide range of turbulence quantities was analysed based upon a stepped spillway case study, using flow depths sampled with Acoustic Displacement Meters as the flow variable of interest. The studied parameters include: the expected free surface level, the expected fluctuation intensity, the depth skewness, the autocorrelation timescales, the vertical velocity fluctuation intensity, the perturbations celerity and the one-dimensional free surface turbulence spectrum. Three levels of filtering were utilised prior to applying classic and robust estimators, showing that comparable robustness can be obtained either using classic estimators together with an intermediate filtering technique or using robust estimators instead, without any filtering technique.}, language = {en} } @article{ValeroSchalkoFriedrichetal.2021, author = {Valero, Daniel and Schalko, Isabella and Friedrich, Heide and Abad, Jorge D. and Bung, Daniel Bernhard and Donchyts, Gennadii and Felder, Stefan and Ferreira, Rui M. L. and Hohermuth, Benjamin and Kramer, Matthias and Li, Danxun and Mendes, Luis and Moreno-Rodenas, Antonio and Nones, Michael and Paron, Paolo and Ruiz-Villanueva, Virginia and Wang, Ruo-Qian and Franca, Mario J.}, title = {Pathways towards democratization of hydro-environment observations and data}, series = {Iahr White Paper Series}, journal = {Iahr White Paper Series}, number = {1}, publisher = {International Association for Hydro-Environment Engineering and Research (IAHR)}, pages = {1 -- 9}, year = {2021}, language = {en} } @article{ValeroVitiGualtieri2019, author = {Valero, Daniel and Viti, Nicolo and Gualtieri, Carlo}, title = {Numerical Simulation of Hydraulic Jumps. Part 1: Experimental Data for Modelling Performance Assessment}, series = {Water}, volume = {11}, journal = {Water}, number = {1}, publisher = {MDPI}, address = {Basel}, issn = {2073-4441}, doi = {10.3390/w11010036}, pages = {Art. Nr. 36}, year = {2019}, language = {en} } @article{VantStaatBaroud2008, author = {Vant, Christianne and Staat, Manfred and Baroud, Gamal}, title = {Percutaneous Vertebroplasty: A Review of Two Intraoperative Complications}, series = {Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.)}, journal = {Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.)}, publisher = {Springer}, address = {Berlin}, isbn = {978-3-540-75408-4}, pages = {527 -- 539}, year = {2008}, language = {en} } @article{VargaDavinsonGloriusetal.2020, author = {Varga, Laszlo and Davinson, Thomas and Glorius, Jan and Jurado, Beatrix and Langer, Christoph and Lederer-Woods, Claudia and Litvinov, Yuri A. and Reifarth, Rene and Slavkovska, Zuzana and St{\"o}hlker, Thomas and Woods, Phil J. and Xing, Yuan Ming}, title = {Towards background-free studies of capture reaction in a heavy-ion storage ring}, series = {Journal of Physics: Conference Series}, volume = {1668}, journal = {Journal of Physics: Conference Series}, number = {Art 012046}, publisher = {IOP}, address = {Bristol}, year = {2020}, abstract = {Stored and cooled, highly-charged ions offer unprecedented capabilities for precision studies in the realm of atomic, nuclear structure and astrophysics[1]. After the successful investigation of the 96Ru(p,7)97Rh reaction cross section in 2009[2], the first measurement of the 124Xe(p,7)125Cs reaction cross section has been performed with decelerated, fully-ionized 124Xe ions in 2016 at the Experimental Storage Ring (ESR) of GSI[3]. Using a Double Sided Silicon Strip Detector, introduced directly into the ultra-high vacuum environment of a storage ring, the 125Cs proton-capture products have been successfully detected. The cross section has been measured at 5 different energies between 5.5AMeV and 8AMeV, on the high energy tail of the Gamow-window for hot, explosive scenarios such as supernovae and X-ray binaries. The elastic scattering on the H2 gas jet target is the major source of background to count the (p,7) events. Monte Carlo simulations show that an additional slit system in the ESR in combination with the energy information of the Si detector will enable background free measurements of the proton-capture products. The corresponding hardware is being prepared and will increase the sensitivity of the method tremendously.}, language = {en} } @article{VelrajSeenirajHafneretal.1997, author = {Velraj, R. and Seeniraj, R. V. and Hafner, B. and Faber, Christian and Schwarzer, Klemens}, title = {Experimental analysis and numerical modelling of inward solidification on a finned vertical tube for a latent heat storage unit}, series = {Solar energy. 60 (1997), H. 5}, journal = {Solar energy. 60 (1997), H. 5}, isbn = {0038-092X}, pages = {281 -- 290}, year = {1997}, language = {en} } @article{VelrajSeenirajHafneretal.1999, author = {Velraj, R. and Seeniraj, R. V. and Hafner, B. and Faber, Christian and Schwarzer, Klemens}, title = {Heat transfer enhancement in a latent heat storage system}, series = {Solar energy. Vol. 65, iss. 3}, journal = {Solar energy. Vol. 65, iss. 3}, issn = {0038-092X}, pages = {171 -- 180}, year = {1999}, language = {en} } @article{VieiradaSilvaSchwarzerHoffschmidtetal.2013, author = {Vieira da Silva, Maria Eugenia and Schwarzer, Klemens and Hoffschmidt, Bernhard and Pinheiro Rodrigues, Frederico and Schwarzer, Tarik and Costa Rocha, Paulo Alexandre}, title = {Mass transfer correlation for evaporation-condensation thermal process in the range of 70 °C-95 °C}, series = {Renewable energy}, volume = {Vol. 53}, journal = {Renewable energy}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1879-0682 (E-Journal); 0960-1481 (Print)}, pages = {174 -- 179}, year = {2013}, language = {en} } @article{VitiValeroGualtieri2019, author = {Viti, Nicolo and Valero, Daniel and Gualtieri, Carlo}, title = {Numerical Simulation of Hydraulic Jumps. Part 2: Recent Results and Future Outlook}, series = {Water}, volume = {11}, journal = {Water}, number = {1}, issn = {2073-4441}, doi = {10.3390/w11010028}, pages = {Art. Nr. 28}, year = {2019}, language = {en} } @article{VitusevichFoersterIndlekoferetal.2000, author = {Vitusevich, S. A. and F{\"o}rster, Arnold and Indlekofer, K.-M. and L{\"u}th, H. and Belyaev, A. E. and Glavin, B. A. and Konakova, R. V.}, title = {Tunneling Through X-Valley-Related Impurity States in GaAs/AlAs Resonant-Tunneling Diodes}, series = {Physical Review . B. 61 (2000), H. 16}, journal = {Physical Review . B. 61 (2000), H. 16}, isbn = {1550-235X}, pages = {10898 -- 10904}, year = {2000}, language = {en} } @article{VitusevichFoersterLuethetal.2001, author = {Vitusevich, S. A. and F{\"o}rster, Arnold and L{\"u}th, H. and Belyaev, A. E. and Danylyuk, S. V. and Konakova, R. V. and Sheka, D. I.}, title = {Resonant spectroscopy of electric-field-induced superlattices}, series = {Journal of Applied Physics. 90 (2001), H. 6}, journal = {Journal of Applied Physics. 90 (2001), H. 6}, isbn = {1089-7550}, doi = {10.1063/1.1392956}, pages = {2857 -- 2861}, year = {2001}, language = {en} } @article{VitusevichFoersterReetzetal.2000, author = {Vitusevich, S. A. and F{\"o}rster, Arnold and Reetz, W. and L{\"u}th, H. and Belyaev, A. E. and Danylyuk, S. V.}, title = {Spectral Responsivity of single-quantum-well photodetectors}, series = {Applied Physics Letters. 77 (2000), H. 1}, journal = {Applied Physics Letters. 77 (2000), H. 1}, isbn = {1077-3118}, pages = {16 -- 18}, year = {2000}, language = {en} } @article{VitusevichFoersterReetzetal.2000, author = {Vitusevich, S. A. and F{\"o}rster, Arnold and Reetz, W. and L{\"u}th, H. and Belyaev, A. E. and Danylyuk, S. V.}, title = {Fine structure of photoresponse spectra in a double-barrier resonant tunnelling diode}, series = {Nanotechnology. 11 (2000), H. 4}, journal = {Nanotechnology. 11 (2000), H. 4}, isbn = {1361-6528}, pages = {305 -- 308}, year = {2000}, language = {en} } @article{VlasovMourzinaLeginetal.2002, author = {Vlasov, Y. G. and Mourzina, Y. G. and Legin, A. V. and Ermelenko, Y. E. and Schubert, J. and Sch{\"o}ning, Michael Josef and L{\"u}th, H.}, title = {Solid-state thin film sensors based on chalcogenide materials prepared by planar technology and pulsed laser deposition}, series = {Russian Journal of Applied Chemistry. 75 (2002), H. 3}, journal = {Russian Journal of Applied Chemistry. 75 (2002), H. 3}, isbn = {1070-4272}, pages = {351 -- 356}, year = {2002}, language = {en} } @article{VogtMottaghyRathetal.2014, author = {Vogt, C. and Mottaghy, Darius and Rath, V. and Marquart, G. and Dijkshoorn, L. and Wolf, A. and Clauser, C.}, title = {Vertical variation in heat flow on the Kola Peninsula: palaeoclimate or fluid flow?}, series = {Geophysical Journal International}, volume = {199}, journal = {Geophysical Journal International}, number = {2}, publisher = {Oxford University Press}, address = {Oxford}, issn = {1365-246X}, doi = {10.1093/gji/ggu282}, pages = {829 -- 843}, year = {2014}, abstract = {Following earlier studies, we present forward and inverse simulations of heat and fluid transport of the upper crust using a local 3-D model of the Kola area. We provide best estimates for palaeotemperatures and permeabilities, their errors and their dependencies. Our results allow discriminating between the two mentioned processes to a certain extent, partly resolving the non-uniqueness of the problem. We find clear indications for a significant contribution of advective heat transport, which, in turn, imply only slightly lower ground surface temperatures during the last glacial maximum relative to the present value. These findings are consistent with the general background knowledge of (i) the fracture zones and the corresponding fluid movements in the bedrock and (ii) the glacial history of the Kola area.}, language = {en} } @article{VogtMottaghyWolfetal.2010, author = {Vogt, C. and Mottaghy, Darius and Wolf, A. and Rath, V. and Pechnig, R. and Clauser, C.}, title = {Reducing temperature uncertainties by stochastic geothermal reservoir modelling}, series = {Geophysical Journal International}, volume = {181}, journal = {Geophysical Journal International}, number = {1}, publisher = {Oxford University Press}, address = {Oxford}, issn = {1365-246X}, doi = {10.1111/j.1365-246X.2009.04498.x}, pages = {321 -- 333}, year = {2010}, abstract = {Quantifying and minimizing uncertainty is vital for simulating technically and economically successful geothermal reservoirs. To this end, we apply a stochastic modelling sequence, a Monte Carlo study, based on (i) creating an ensemble of possible realizations of a reservoir model, (ii) forward simulation of fluid flow and heat transport, and (iii) constraining post-processing using observed state variables. To generate the ensemble, we use the stochastic algorithm of Sequential Gaussian Simulation and test its potential fitting rock properties, such as thermal conductivity and permeability, of a synthetic reference model and—performing a corresponding forward simulation—state variables such as temperature. The ensemble yields probability distributions of rock properties and state variables at any location inside the reservoir. In addition, we perform a constraining post-processing in order to minimize the uncertainty of the obtained distributions by conditioning the ensemble to observed state variables, in this case temperature. This constraining post-processing works particularly well on systems dominated by fluid flow. The stochastic modelling sequence is applied to a large, steady-state 3-D heat flow model of a reservoir in The Hague, Netherlands. The spatial thermal conductivity distribution is simulated stochastically based on available logging data. Errors of bottom-hole temperatures provide thresholds for the constraining technique performed afterwards. This reduce the temperature uncertainty for the proposed target location significantly from 25 to 12 K (full distribution width) in a depth of 2300 m. Assuming a Gaussian shape of the temperature distribution, the standard deviation is 1.8 K. To allow a more comprehensive approach to quantify uncertainty, we also implement the stochastic simulation of boundary conditions and demonstrate this for the basal specific heat flow in the reservoir of The Hague. As expected, this results in a larger distribution width and hence, a larger, but more realistic uncertainty estimate. However, applying the constraining post-processing the uncertainty is again reduced to the level of the post-processing without stochastic boundary simulation. Thus, constraining post-processing is a suitable tool for reducing uncertainty estimates by observed state variables.}, language = {en} } @article{VogtIwanowskiStrahserMarquartetal.2013, author = {Vogt, Christian and Iwanowski-Strahser, Katha and Marquart, Gabriele and Arnold, Juliane and Mottaghy, Darius and Pechnig, Renate and Gnjezda, Daniel and Clauser, Christoph}, title = {Modeling contribution to risk assessment of thermal production power for geothermal reservoirs}, series = {Renewable Energy}, volume = {53}, journal = {Renewable Energy}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0960-1481}, doi = {10.1016/j.renene.2012.11.026}, pages = {230 -- 241}, year = {2013}, language = {en} } @article{VoigtAlbrechtSieversetal.2015, author = {Voigt, Birgit and Albrecht, Dirk and Sievers, Susanne and Becher, D{\"o}rte and Bongaerts, Johannes and Evers, Stefan and Schweder, Thomas and Maurer, Karl-Heinz and Hecker, Michael}, title = {High-resolution proteome maps of Bacillus licheniformis cells growing in minimal medium}, series = {Proteomics}, volume = {15}, journal = {Proteomics}, number = {15}, publisher = {Wiley}, address = {Weinheim}, issn = {1615-9861}, doi = {10.1002/pmic.201400504}, pages = {2629 -- 2633}, year = {2015}, language = {en} } @article{VoigtSchroeterJuergenetal.2013, author = {Voigt, Birgit and Schroeter, Rebecca and J{\"u}rgen, Britta and Albrecht, Dirk and Evers, Stefan and Bongaerts, Johannes and Maurer, Karl-Heinz and Schweder, Thomas and Hecker, Michael}, title = {The response of Bacillus licheniformis to heat and ethanol stress and the role of the SigB regulon}, series = {Proteomics}, volume = {Vol. 13}, journal = {Proteomics}, number = {Iss. 14}, publisher = {Wiley}, address = {Weinheim}, issn = {1615-9861 (E-Journal); 1615-9853 (Print)}, pages = {2140 -- 2146}, year = {2013}, language = {en} } @article{vonHaefenKrautwaldStolleetal.2022, author = {von H{\"a}fen, Hajo and Krautwald, Clemens and Stolle, Jacob and Bung, Daniel Bernhard and Goseberg, Nils}, title = {Overland flow of broken solitary waves over a two-dimensional coastal plane}, series = {Coastal Engineering}, volume = {175}, journal = {Coastal Engineering}, number = {August}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1872-7379}, doi = {10.1016/j.coastaleng.2022.104125}, pages = {14 Seiten}, year = {2022}, abstract = {Landslides, rock falls or related subaerial and subaqueous mass slides can generate devastating impulse waves in adjacent waterbodies. Such waves can occur in lakes and fjords, or due to glacier calving in bays or at steep ocean coastlines. Infrastructure and residential houses along coastlines of those waterbodies are often situated on low elevation terrain, and are potentially at risk from inundation. Impulse waves, running up a uniform slope and generating an overland flow over an initially dry adjacent horizontal plane, represent a frequently found scenario, which needs to be better understood for disaster planning and mitigation. This study presents a novel set of large-scale flume test focusing on solitary waves propagating over a 1:14.5 slope and breaking onto a horizontal section. Examining the characteristics of overland flow, this study gives, for the first time, insight into the fundamental process of overland flow of a broken solitary wave: its shape and celerity, as well as its momentum when wave breaking has taken place beforehand.}, language = {en} } @article{vonKnobelsdorfBrenkenhoffFrauenrathProthmannetal.2010, author = {von Knobelsdorf-Brenkenhoff, Florian and Frauenrath, Tobias and Prothmann, Marcel and Dieringer, Matthias A. and Hezel, Fabian and Renz, Wolfgang and Kretschel, Kerstin and Niendorf, Thoralf and Schulz-Menger, Jeanette}, title = {Cardiac chamber quantification using magnetic resonance imaging at 7 Tesla—a pilot study}, volume = {20}, publisher = {Springer}, address = {Berlin, Heidelberg}, issn = {0938-7994}, doi = {10.1007/s00330-010-1888-2}, pages = {2844 -- 2852}, year = {2010}, abstract = {Objectives Interest in cardiovascular magnetic resonance (CMR) at 7 T is motivated by the expected increase in spatial and temporal resolution, but the method is technically challenging. We examined the feasibility of cardiac chamber quantification at 7 T. Methods A stack of short axes covering the left ventricle was obtained in nine healthy male volunteers. At 1.5 T, steady-state free precession (SSFP) and fast gradient echo (FGRE) cine imaging with 7 mm slice thickness (STH) were used. At 7 T, FGRE with 7 mm and 4 mm STH were applied. End-diastolic volume, end-systolic volume, ejection fraction and mass were calculated. Results All 7 T examinations provided excellent blood/myocardium contrast for all slice directions. No significant difference was found regarding ejection fraction and cardiac volumes between SSFP at 1.5 T and FGRE at 7 T, while volumes obtained from FGRE at 1.5 T were underestimated. Cardiac mass derived from FGRE at 1.5 and 7 T was larger than obtained from SSFP at 1.5 T. Agreement of volumes and mass between SSFP at 1.5 T and FGRE improved for FGRE at 7 T when combined with an STH reduction to 4 mm. Conclusions This pilot study demonstrates that cardiac chamber quantification at 7 T using FGRE is feasible and agrees closely with SSFP at 1.5 T.}, language = {en} } @article{VorstFerreinLakemeyer2006, author = {Vorst, Phillip and Ferrein, Alexander and Lakemeyer, Gerhard}, title = {AllemaniACs3D team description}, pages = {1 -- 6}, year = {2006}, language = {en} } @article{VosLagemaatBarentszetal.2014, author = {Vos, E. K. and Lagemaat, M. W. and Barentsz, J. O. and F{\"u}tterer, J. J. and Zamecnik, P. and Roozen, H. and Orzada, S. and Bitz, Andreas and Maas, M. C. and Scheenen, T. W. J.}, title = {Image quality and cancer visibility of T2-weighted Magnetic Resonance Imaging of the prostate at 7 Tesla}, series = {European Radiology}, volume = {24}, journal = {European Radiology}, number = {8}, publisher = {Springer}, address = {Cham}, issn = {1432-1084}, doi = {10.1007/s00330-014-3234-6}, pages = {1950 -- 1958}, year = {2014}, abstract = {Objectives To assess the image quality of T2-weighted (T2w) magnetic resonance imaging of the prostate and the visibility of prostate cancer at 7 Tesla (T). Materials \& methods Seventeen prostate cancer patients underwent T2w imaging at 7T with only an external transmit/receive array coil. Three radiologists independently scored images for image quality, visibility of anatomical structures, and presence of artefacts. Krippendorff's alpha and weighted kappa statistics were used to assess inter-observer agreement. Visibility of prostate cancer lesions was assessed by directly linking the T2w images to the confirmed location of prostate cancer on histopathology. Results T2w imaging at 7T was achievable with 'satisfactory' (3/5) to 'good' (4/5) quality. Visibility of anatomical structures was predominantly scored as 'satisfactory' (3/5) and 'good' (4/5). If artefacts were present, they were mostly motion artefacts and, to a lesser extent, aliasing artefacts and noise. Krippendorff's analysis revealed an α = 0.44 between three readers for the overall image quality scores. Clinically significant cancer lesions in both peripheral zone and transition zone were visible at 7T. Conclusion T2w imaging with satisfactory to good quality can be routinely acquired, and cancer lesions were visible in patients with prostate cancer at 7T using only an external transmit/receive body array coil.}, language = {en} } @article{VuStaat2007, author = {Vu, Duc Khoi and Staat, Manfred}, title = {Shakedown analysis of structures made of materials with temperature-dependent yield stress}, series = {International Journal of Solids and Structures. 44 (2007), H. 13}, journal = {International Journal of Solids and Structures. 44 (2007), H. 13}, isbn = {0020-7683}, pages = {4524 -- 4540}, year = {2007}, language = {en} } @article{VuStaatTran2007, author = {Vu, Duc Khoi and Staat, Manfred and Tran, Ich Thinh}, title = {Analysis of pressure equipment by application of the primal-dual theory of shakedown}, series = {Communications in Numerical Methods in Engineering. 23 (2007), H. 3}, journal = {Communications in Numerical Methods in Engineering. 23 (2007), H. 3}, isbn = {1069-8299}, pages = {213 -- 225}, year = {2007}, language = {en} } @article{VuStaat2004, author = {Vu, Duc-Khoi and Staat, Manfred}, title = {An algorithm for shakedown analysis of structure with temperature dependent yield stress}, year = {2004}, abstract = {This work is an attempt to answer the question: How to use convex programming in shakedown analysis of structures made of materials with temperature-dependent properties. Based on recently established shakedown theorems and formulations, a dual relationship between upper and lower bounds of the shakedown limit load is found, an algorithmfor shakedown analysis is proposed. While the original problem is neither convex nor concave, the algorithm presented here has the advantage of employing convex programming tools.}, subject = {Einspielen }, language = {en} } @article{VoegeleGrajewskiGovorukhaetal.2020, author = {V{\"o}gele, Stefan and Grajewski, Matthias and Govorukha, Kristina and R{\"u}bbelke, Dirk}, title = {Challenges for the European steel industry: Analysis, possible consequences and impacts on sustainable development}, series = {Applied Energy}, volume = {264}, journal = {Applied Energy}, number = {Article number: 114633}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0306-2619}, doi = {10.1016/j.apenergy.2020.114633}, year = {2020}, abstract = {The steel industry in the European Union (EU), important for the economy as a whole, faces various challenges. These are inter alia volatile prices for relevant input factors, uncertainties concerning the regulation of CO₂-emissions and market shocks caused by the recently introduced additional import duties in the US, which is an important sales market. We examine primary and secondary effects of these challenges on the steel industry in the EU and their impacts on European and global level. Developing and using a suitable meta-model, we analyze the competitiveness of key steel producing countries with respect to floor prices depending on selected cost factors and draw conclusions on the impacts in the trade of steel on emissions, energy demand, on the involvement of developing countries in the value chain as well on the need for innovations to avoid relocations of production. Hence, our study contributes to the assessment of sustainable industrial development, which is aimed by the Sustainability Development Goal "Build resilient infrastructure, promote inclusive and sustainable industrialization and foster innovation countries". By applying information on country-specific Human Development Indexes (reflecting aspects of life expectancy, education, and per capita income), we show that relocating energy-intensive industries from the EU may not only increase global energy demand and CO₂-emissions, but may also be to the disadvantage of developing countries.}, language = {en} } @article{VoegeleJosyabhatlaBalletal.2023, author = {V{\"o}gele, Stefan and Josyabhatla, Vishnu Teja and Ball, Christopher and Rhoden, Imke and Grajewski, Matthias and R{\"u}bbelke, Dirk and Kuckshinrichs, Wilhelm}, title = {Robust assessment of energy scenarios from stakeholders' perspectives}, series = {Energy}, journal = {Energy}, number = {In Press, Article 128326}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1873-6785 (Online)}, doi = {10.1016/j.energy.2023.128326}, year = {2023}, abstract = {Using scenarios is vital in identifying and specifying measures for successfully transforming the energy system. Such transformations can be particularly challenging and require the support of a broader set of stakeholders. Otherwise, there will be opposition in the form of reluctance to adopt the necessary technologies. Usually, processes for considering stakeholders' perspectives are very time-consuming and costly. In particular, there are uncertainties about how to deal with modifications in the scenarios. In principle, new consulting processes will be required. In our study, we show how multi-criteria decision analysis can be used to analyze stakeholders' attitudes toward transition paths. Since stakeholders differ regarding their preferences and time horizons, we employ a multi-criteria decision analysis approach to identify which stakeholders will support or oppose a transition path. We provide a flexible template for analyzing stakeholder preferences toward transition paths. This flexibility comes from the fact that our multi-criteria decision aid-based approach does not involve intensive empirical work with stakeholders. Instead, it involves subjecting assumptions to robustness analysis, which can help identify options to influence stakeholders' attitudes toward transitions.}, language = {en} } @article{VoegeleRuebbelkeGovorukhaetal.2019, author = {V{\"o}gele, Stefan and R{\"u}bbelke, Dirk and Govorukha, Kristina and Grajewski, Matthias}, title = {Socio-technical scenarios for energy-intensive industries: the future of steel production in Germany}, series = {Climatic Change}, journal = {Climatic Change}, publisher = {Springer}, address = {Berlin}, issn = {0165-0009}, doi = {10.1007/s10584-019-02366-0}, pages = {1 -- 16}, year = {2019}, language = {en} } @article{WackwitzBongaertsGoodmanetal.1999, author = {Wackwitz, B. and Bongaerts, Johannes and Goodman, S. D. and Unden, Gottfried}, title = {Growth phase-dependent regulation of nuoA-N expression in Escherichia coli K-12 by the Fis protein: upstream binding sites and bioenergetic significance}, series = {Molecular and general genetics : MGG}, volume = {Vol. 262}, journal = {Molecular and general genetics : MGG}, number = {Iss. 4 - 5}, issn = {1617-4623 (E-Journal); 1617-4615 (Print)}, pages = {876 -- 883}, year = {1999}, language = {en} } @article{WagnerDollSchoening2014, author = {Wagner, Patrick and Doll, Theodor and Sch{\"o}ning, Michael Josef}, title = {Engineering of functional interfaces / Patrick Wagner ; Theodor Doll ; Michael J. Sch{\"o}ning (eds.)}, series = {Physica status solidi (A) : Applications and materials science}, volume = {211}, journal = {Physica status solidi (A) : Applications and materials science}, number = {6}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1521-396X (E-Book); 1862-6319 (E-Book); 0031-8965 (Print); 1862-6300 (Print)}, doi = {10.1002/pssa.201470241}, pages = {1339 -- 1339}, year = {2014}, language = {en} } @article{WagnerKloockSchoening2007, author = {Wagner, Torsten and Kloock, Joachim P. and Sch{\"o}ning, Michael Josef}, title = {Determination of cadmium concentration and pH value in aqueous solutions by means of a handheld light-addressable potentiometric sensor (LAPS) device}, series = {Electrochemical sensor analysis / edited by S. Alegret ...}, journal = {Electrochemical sensor analysis / edited by S. Alegret ...}, publisher = {Elsevier}, address = {Amsterdam}, isbn = {978-0-444-53133-9}, pages = {e35 -- e44}, year = {2007}, language = {en} } @article{WagnerMarisAckermannetal.2007, author = {Wagner, Torsten and Maris, Rob J. and Ackermann, Hans-Josef and Otto, Ralph and Beging, Stefan and Poghossian, Arshak and Sch{\"o}ning, Michael Josef}, title = {Handheld measurement device for field-effect sensor structures: Practical evaluation and limitations}, series = {Sensors and Actuators B: Chemical . 127 (2007), H. 1}, journal = {Sensors and Actuators B: Chemical . 127 (2007), H. 1}, isbn = {0925-4005}, pages = {217 -- 223}, year = {2007}, language = {en} } @article{WagnerMiyamotoWerneretal.2011, author = {Wagner, Torsten and Miyamoto, K. and Werner, Frederik and Sch{\"o}ning, Michael Josef and Yoshinobu, T.}, title = {Flexible electrochemical imaging with "zoom-in" functionality by using a new type of light-addressable potentiometric sensor}, publisher = {IEEE}, address = {New York}, pages = {2133 -- 2135}, year = {2011}, language = {en} } @article{WagnerMiyamotoWerneretal.2011, author = {Wagner, Torsten and Miyamoto, K. and Werner, Frederik and Sch{\"o}ning, Michael Josef and Yoshinobu, T.}, title = {Utilising Digital Micro-Mirror Device (DMD) as Scanning Light Source for Light-Addressable Potentiometric Sensors (LAPS)}, volume = {9}, number = {2}, publisher = {American Scientific Publishers}, address = {Stevenson Ranch, Calif.}, doi = {10.1166/sl.2011.1620}, pages = {812 -- 815}, year = {2011}, language = {en} } @article{WagnerMiyamotoSchoeningetal.2010, author = {Wagner, Torsten and Miyamoto, Ko-ichiro and Sch{\"o}ning, Michael Josef and Yoshinobu, Tatsuo}, title = {Novel combination of digital light processing (DLP) and light-addressable potentiometric sensors (LAPS) for flexible chemical imaging}, series = {Procedia Engineering. 5 (2010)}, journal = {Procedia Engineering. 5 (2010)}, isbn = {1877-7058}, pages = {520 -- 523}, year = {2010}, language = {en} } @article{WagnerMiyamotoShigiharaetal.2011, author = {Wagner, Torsten and Miyamoto, Ko-ichiro and Shigihara, Noriko and Sch{\"o}ning, Michael Josef and Yoshinobu, Tatsuo}, title = {Microfluidic systems with free definable sensor spots by an integrated light-addressable potentiometric sensor}, series = {Procedia Engineering. 25 (2011)}, journal = {Procedia Engineering. 25 (2011)}, publisher = {Elsevier}, address = {Amsterdam}, isbn = {1877-7058}, pages = {791 -- 794}, year = {2011}, language = {en} } @article{WagnerMolinaBisellietal.2007, author = {Wagner, Torsten and Molina, R. and Biselli, Manfred and Canzoneri, Michele and Schnitzler, Thomas and Yoshinobu, Tatsuo and Sch{\"o}ning, Michael Josef}, title = {A light-addressable potentiometric sensor system for fast, simultaneous and spatial detection of the metabolic activity of biological cells}, series = {Transducers '07 Eurosensors XXI : digest of technical papers ; the14th International Conference on Solid-State Sensors, Actuators and Microsystems, June 10-14, 2007, Lyon, France / Gilles Delapierre (Ed.)}, journal = {Transducers '07 Eurosensors XXI : digest of technical papers ; the14th International Conference on Solid-State Sensors, Actuators and Microsystems, June 10-14, 2007, Lyon, France / Gilles Delapierre (Ed.)}, publisher = {IEEE}, address = {Piscataway}, isbn = {1-4244-0841-5}, pages = {1107 -- 1110}, year = {2007}, language = {en} } @article{WagnerMolinaYoshinobuetal.2007, author = {Wagner, Torsten and Molina, Roberto and Yoshinobu, Tatsuo and Kloock, Joachim P. and Biselli, Manfred and Canzoneri, Michele and Schnitzler, Thomas and Sch{\"o}ning, Michael Josef}, title = {Handheld multi-channel LAPS device as a transducer platform for possible biological and chemical multi-sensor applications}, series = {Electrochimica Acta. 53 (2007), H. 2}, journal = {Electrochimica Acta. 53 (2007), H. 2}, isbn = {0013-4686}, pages = {305 -- 311}, year = {2007}, language = {en} } @article{WagnerRaoKloocketal.2006, author = {Wagner, Torsten and Rao, C. and Kloock, Joachim P. and Yoshinobu, T. and Otto, R. and Keusgen, M. and Sch{\"o}ning, Michael Josef}, title = {"LAPS Card"—A novel chip card-based light-addressable potentiometric sensor (LAPS)}, series = {Sensors and Actuators B: Chemical. 118 (2006), H. 1-2}, journal = {Sensors and Actuators B: Chemical. 118 (2006), H. 1-2}, isbn = {0925-4005}, pages = {33 -- 40}, year = {2006}, language = {en} } @article{WagnerSchoening2007, author = {Wagner, Torsten and Sch{\"o}ning, Michael Josef}, title = {Light-addressable potentiometric sensors (LAPS): recent trends and applications}, series = {Electrochemical sensor analysis / edited by S. Alegret ...}, journal = {Electrochemical sensor analysis / edited by S. Alegret ...}, publisher = {Elsevier}, address = {Amsterdam}, isbn = {978-0-444-53053-0}, pages = {87 -- 128}, year = {2007}, language = {en} } @article{WagnerSchoeningOttoetal.2004, author = {Wagner, Torsten and Sch{\"o}ning, Michael Josef and Otto, R. and Yoshinobu, T.}, title = {A handheld 16 channel pen-type LAPS as a platform for (bio-)electrochemical sensing}, series = {Biomedizinische Technik. 49 (2004), H. 2}, journal = {Biomedizinische Technik. 49 (2004), H. 2}, isbn = {0932-4666}, pages = {996 -- 997}, year = {2004}, language = {en} } @article{WagnerShigiaharaMiyamotoetal.2012, author = {Wagner, Torsten and Shigiahara, N. and Miyamoto, K. and Suzurikawa, J. and Finger, F. and Sch{\"o}ning, Michael Josef and Yoshinobu, T.}, title = {Light-addressable Potentiometric Sensors and Light-addressable Electrodes as a Combined Sensor-and-manipulator Microsystem with High Flexibility}, series = {Procedia Engineering}, journal = {Procedia Engineering}, number = {47}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1877-7058}, doi = {10.1016/j.proeng.2012.09.290}, pages = {890 -- 893}, year = {2012}, abstract = {This work describes the novel combination of the light-addressable electrode (LAE) and the light-addressable potentiometric sensor (LAPS) into a microsystem set-up. Both the LAE as well as the LAPS shares the principle of addressing the active spot by means of a light beam. This enables both systems to manipulate resp. to detect an analyte with a high spatial resolution. Hence, combining both principles into a single set-up enables the active stimulation e.g., by means of electrolysis and a simultaneous observation e.g., the response of an entrapped biological cell by detection of extracellular pH changes. The work will describe the principles of both technologies and the necessary steps to integrate them into a single set-up. Furthermore, examples of application and operation of such systems will be presented.}, language = {en} } @article{WagnerVornholtWerneretal.2016, author = {Wagner, Torsten and Vornholt, Wolfgang and Werner, Frederik and Yoshinobu, Tatsuo and Miyamoto, Ko-Ichiro and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Light-addressable potentiometric sensor (LAPS) combined with magnetic beads for pharmaceutical screening}, series = {Physics in medicine}, volume = {2016}, journal = {Physics in medicine}, number = {1}, issn = {2352-4510}, doi = {10.1016/j.phmed.2016.03.001}, pages = {2 -- 7}, year = {2016}, abstract = {The light-addressable potentiometric sensor (LAPS) has the unique feature to address different regions of a sensor surface without the need of complex structures. Measurements at different locations on the sensor surface can be performed in a common analyte solution, which distinctly simplifies the fluidic set-up. However, the measurement in a single analyte chamber prevents the application of different drugs or different concentrations of a drug to each measurement spot at the same time as in the case of multi-reservoir-based set-ups. In this work, the authors designed a LAPS-based set-up for cell culture screening that utilises magnetic beads loaded with the endotoxin (lipopolysaccharides, LPS), to generate a spatially distributed gradient of analyte concentration. Different external magnetic fields can be adjusted to move the magnetic beads loaded with a specific drug within the measurement cell. By recording the metabolic activities of a cell layer cultured on top of the LAPS surface, this work shows the possibility to apply different concentrations of a sample along the LAPS measurement spots within a common analyte solution.}, language = {en} } @article{WagnerWernerMiyamotoetal.2009, author = {Wagner, Torsten and Werner, Frederik and Miyamoto, K. and Sch{\"o}ning, Michael Josef and Yoshinobu, T.}, title = {A high-density multi-point LAPS set-up using a VCSEL array and FPGA control}, series = {Procedia Chemistry. 1 (2009), H. 1}, journal = {Procedia Chemistry. 1 (2009), H. 1}, publisher = {Elsevier}, address = {Amsterdam}, isbn = {1876-6196}, pages = {1483 -- 1486}, year = {2009}, language = {en} } @article{WagnerWernerMiyamotoetal.2010, author = {Wagner, Torsten and Werner, Frederik and Miyamoto, Ko-ichiro and Ackermann, Hans-Josef and Yoshinobu, Tatsuo and Sch{\"o}ning, Michael Josef}, title = {FPGA-based LAPS device for the flexible design of sensing sites on functional interfaces}, series = {Physica Status Solidi (A). 207 (2010), H. 4}, journal = {Physica Status Solidi (A). 207 (2010), H. 4}, isbn = {1862-6300}, pages = {844 -- 849}, year = {2010}, language = {en} } @article{WagnerWernerMiyamotoetal.2012, author = {Wagner, Torsten and Werner, Frederik and Miyamoto, Ko-Ichiro and Sch{\"o}ning, Michael Josef and Yoshinobu, Tatsuo}, title = {Development and characterisation of a compact light-addressable potentiometric sensor (LAPS) based on the digital light processing (DLP) technology for flexible chemical imaging}, series = {Sensors and Actuators B: Chemical}, volume = {170}, journal = {Sensors and Actuators B: Chemical}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0925-4005}, doi = {10.1016/j.snb.2010.12.003}, pages = {34 -- 39}, year = {2012}, abstract = {Chemical imaging systems allow the visualisation of the distribution of chemical species on the sensor surface. This work represents a new flexible approach to read out light-addressable potentiometric sensors (LAPS) with the help of a digital light processing (DLP) set-up. The DLP, known well for video projectors, consists of a mirror-array MEMS device, which allows fast and flexible generation of light patterns. With the help of these light patterns, the sensor surface of the LAPS device can be addressed. The DLP approach has several advantages compared to conventional LAPS set-ups, e.g., the spot size and the shape of the light pointer can be changed easily and no mechanical movement is necessary, which reduces the size of the set-up and increases the stability and speed of the measurement. In addition, the modulation frequency and intensity of the light beam are important parameters of the LAPS set-up. Within this work, the authors will discuss two different ways of light modulation by the DLP set-up, investigate the influence of different modulation frequencies and different light intensities as well as demonstrate the scanning capabilities of the new set-up by pH mapping on the sensor surface.}, language = {en} } @article{WagnerWernerMiyamotoetal.2011, author = {Wagner, Torsten and Werner, Frederik and Miyamoto, Ko-Ichiro and Sch{\"o}ning, Michael Josef and Yoshinobu, Tatsuo}, title = {A high-density multi-point LAPS set-up using a VCSEL array and FPGA control}, series = {Sensors and Actuators B: Chemical. 154 (2011), H. 2}, journal = {Sensors and Actuators B: Chemical. 154 (2011), H. 2}, publisher = {Elsevier}, address = {Amsterdam}, isbn = {1873-3077}, pages = {124 -- 128}, year = {2011}, language = {en} } @article{WagnerYoshinobuRaoetal.2005, author = {Wagner, Torsten and Yoshinobu, T. and Rao, C. and Otto, R. and Sch{\"o}ning, Michael Josef}, title = {„All-in-one" solid-state device based on a lightaddressable potentiometric sensor platform}, series = {Transducers '05 : the 13th International Conference on Solid-State Sensors, Actuators and Microsystems ; Seoul, Korea, [June 5 - 9, 2005] ; digest of technical papers / sponsored by Korean Sensors Society. Technical co-sponsors: IEEE Electron Devices Society}, journal = {Transducers '05 : the 13th International Conference on Solid-State Sensors, Actuators and Microsystems ; Seoul, Korea, [June 5 - 9, 2005] ; digest of technical papers / sponsored by Korean Sensors Society. Technical co-sponsors: IEEE Electron Devices Society}, publisher = {IEEE Operations Center}, address = {Piscataway, NJ}, isbn = {0-7803-83995-6}, pages = {1872 -- 1875}, year = {2005}, language = {en} } @article{WaldvogelFreylerHelmetal.2023, author = {Waldvogel, Janice and Freyler, Kathrin and Helm, Michael and Monti, Elena and St{\"a}udle, Benjamin and Gollhofer, Albert and Narici, Marco V. and Ritzmann, Ramona and Albracht, Kirsten}, title = {Changes in gravity affect neuromuscular control, biomechanics, and muscle-tendon mechanics in energy storage and dissipation tasks}, series = {Journal of Applied Physiology}, volume = {134}, journal = {Journal of Applied Physiology}, number = {1}, publisher = {American Physiological Society}, address = {Bethesda, Md.}, issn = {1522-1601 (Onlineausgabe)}, doi = {10.1152/japplphysiol.00279.2022}, pages = {190 -- 202}, year = {2023}, abstract = {This study evaluates neuromechanical control and muscle-tendon interaction during energy storage and dissipation tasks in hypergravity. During parabolic flights, while 17 subjects performed drop jumps (DJs) and drop landings (DLs), electromyography (EMG) of the lower limb muscles was combined with in vivo fascicle dynamics of the gastrocnemius medialis, two-dimensional (2D) kinematics, and kinetics to measure and analyze changes in energy management. Comparisons were made between movement modalities executed in hypergravity (1.8 G) and gravity on ground (1 G). In 1.8 G, ankle dorsiflexion, knee joint flexion, and vertical center of mass (COM) displacement are lower in DJs than in DLs; within each movement modality, joint flexion amplitudes and COM displacement demonstrate higher values in 1.8 G than in 1 G. Concomitantly, negative peak ankle joint power, vertical ground reaction forces, and leg stiffness are similar between both movement modalities (1.8 G). In DJs, EMG activity in 1.8 G is lower during the COM deceleration phase than in 1 G, thus impairing quasi-isometric fascicle behavior. In DLs, EMG activity before and during the COM deceleration phase is higher, and fascicles are stretched less in 1.8 G than in 1 G. Compared with the situation in 1 G, highly task-specific neuromuscular activity is diminished in 1.8 G, resulting in fascicle lengthening in both movement modalities. Specifically, in DJs, a high magnitude of neuromuscular activity is impaired, resulting in altered energy storage. In contrast, in DLs, linear stiffening of the system due to higher neuromuscular activity combined with lower fascicle stretch enhances the buffering function of the tendon, and thus the capacity to safely dissipate energy.}, language = {en} } @article{WaldvogelRitzmannFreyleretal.2021, author = {Waldvogel, Janice and Ritzmann, Ramona and Freyler, Kathrin and Helm, Michael and Monti, Elena and Albracht, Kirsten and St{\"a}udle, Benjamin and Gollhofer, Albert and Narici, Marco}, title = {The Anticipation of Gravity in Human Ballistic Movement}, series = {Frontiers in Physiology}, journal = {Frontiers in Physiology}, publisher = {Frontiers}, address = {Lausanne}, issn = {1664-042X}, doi = {10.3389/fphys.2021.614060}, year = {2021}, abstract = {Stretch-shortening type actions are characterized by lengthening of the pre-activated muscle-tendon unit (MTU) in the eccentric phase immediately followed by muscle shortening. Under 1 g, pre-activity before and muscle activity after ground contact, scale muscle stiffness, which is crucial for the recoil properties of the MTU in the subsequent push-off. This study aimed to examine the neuro-mechanical coupling of the stretch-shortening cycle in response to gravity levels ranging from 0.1 to 2 g. During parabolic flights, 17 subjects performed drop jumps while electromyography (EMG) of the lower limb muscles was combined with ultrasound images of the gastrocnemius medialis, 2D kinematics and kinetics to depict changes in energy management and performance. Neuro-mechanical coupling in 1 g was characterized by high magnitudes of pre-activity and eccentric muscle activity allowing an isometric muscle behavior during ground contact. EMG during pre-activity and the concentric phase systematically increased from 0.1 to 1 g. Below 1 g the EMG in the eccentric phase was diminished, leading to muscle lengthening and reduced MTU stretches. Kinetic energy at take-off and performance were decreased compared to 1 g. Above 1 g, reduced EMG in the eccentric phase was accompanied by large MTU and muscle stretch, increased joint flexion amplitudes, energy loss and reduced performance. The energy outcome function established by linear mixed model reveals that the central nervous system regulates the extensor muscles phase- and load-specifically. In conclusion, neuro-mechanical coupling appears to be optimized in 1 g. Below 1 g, the energy outcome is compromised by reduced muscle stiffness. Above 1 g, loading progressively induces muscle lengthening, thus facilitating energy dissipation.}, language = {en} } @article{WallerBraunHojdisetal.2007, author = {Waller, Mark P. and Braun, Heiko and Hojdis, Nils and B{\"u}hl, Michael}, title = {Geometries of Second-Row Transition-Metal Complexes from Density-Functional Theory}, series = {Journal of Chemical Theory and Computation}, volume = {3}, journal = {Journal of Chemical Theory and Computation}, number = {6}, issn = {1549-9626}, doi = {10.1021/ct700178y}, pages = {2234 -- 2242}, year = {2007}, language = {en} } @article{WaltherGerthsenCariusetal.1993, author = {Walther, T. and Gerthsen, D. and Carius, Reinhard and F{\"o}rster, Arnold}, title = {AlAs/GaAs Quantum well structures: Interface properties investigated by high-resolution transmission electron microscopy and photoluminescence spectroscopy / T. Walther ; D. Gerthsen ; R. Carius ; A. F{\"o}rster ...}, series = {Microscopy of semiconducting materials 1993 : proceedings of the Royal Microscopical Society Conference held at Oxford University, 5 - 8 April 1993 / ed. by A. G. Cullis ... - (Conference series / Institute of Physics ; 134)}, journal = {Microscopy of semiconducting materials 1993 : proceedings of the Royal Microscopical Society Conference held at Oxford University, 5 - 8 April 1993 / ed. by A. G. Cullis ... - (Conference series / Institute of Physics ; 134)}, publisher = {Institute of Physics}, address = {Bristol [u.a.]}, isbn = {0-7503-0290-9}, pages = {449 -- ff.}, year = {1993}, language = {en} } @article{WangKrauseBlocketal.2003, author = {Wang, J. and Krause, R. and Block, K. and Musameh, M. and Mulchandani, A. and Sch{\"o}ning, Michael Josef}, title = {Flow injection amperometric detection of OP nerve agents based on organophosphorus-hydrolase biosensor detector}, series = {Biosensors \& Bioelectronics. 18 (2003), H. 2-3}, journal = {Biosensors \& Bioelectronics. 18 (2003), H. 2-3}, isbn = {0956-5663}, pages = {255 -- 260}, year = {2003}, language = {en} } @article{WangAnikFrohberg1987, author = {Wang, Mao and Anik, Sabri and Frohberg, Martin G.}, title = {Thermodynamics of oxygen in the lead-antimony system at 1173 K}, series = {Erzmetall : Rohstoffgewinnung, Verarbeitung, Recycling, Umwelttechnik}, volume = {40}, journal = {Erzmetall : Rohstoffgewinnung, Verarbeitung, Recycling, Umwelttechnik}, number = {6}, issn = {0044-2658}, pages = {316 -- 319}, year = {1987}, language = {en} } @article{WangAnikFrohberg1988, author = {Wang, Mao and Anik, Sabri and Frohberg, Martin G.}, title = {Experiments on the electrochemical determination of the sulphur activities in the system copper-silver at 1200°C}, series = {Zeitschrift f{\"u}r Metallkunde}, volume = {79}, journal = {Zeitschrift f{\"u}r Metallkunde}, number = {5}, issn = {0044-3093}, pages = {336 -- 339}, year = {1988}, language = {en} } @article{WangDruckenmuellerElbersetal.2014, author = {Wang, Ren-Qi and Druckenm{\"u}ller, Katharina and Elbers, Gereon and Guenther, Klaus and Crou{\´e}, Jean-Philippe}, title = {Analysis of aquatic-phase natural organic matter by optimized LDI-MS method}, series = {Journal of mass spectrometry}, volume = {49}, journal = {Journal of mass spectrometry}, number = {2}, publisher = {Wiley}, address = {Bognor Regis}, issn = {1096-9888}, doi = {10.1002/jms.3321}, pages = {154 -- 160}, year = {2014}, abstract = {The composition and physiochemical properties of aquatic-phase natural organic matter (NOM) are most important problems for both environmental studies and water industry. Laser desorption/ionization (LDI) mass spectrometry facilitated successful examinations of NOM, as humic and fulvic acids in NOM are readily ionized by the nitrogen laser. In this study, hydrophobic NOMs (HPO NOMs) from river, reservoir and waste water were characterized by this technique. The effect of analytical variables like concentration, solvent composition and laser energy was investigated. The exact masses of small molecular NOM moieties in the range of 200-1200 m/z were determined in reflectron mode. In addition, spectra of post-source-decay experiments in this range showed that some compounds from different natural NOMs had the same fragmental ions. In the large mass range of 1200-15 000 Da, macromolecules and their aggregates were found in HPO NOMs from natural waters. Highly humic HPO exhibited mass peaks larger than 8000 Da. On the other hand, the waste water and reservoir water mainly had relatively smaller molecules of about 2000 Da. The LDI-MS measurements indicated that highly humic river waters were able to form large aggregates and membrane foulants, while the HPO NOMs from waste water and reservoir water were unlikely to form large aggregates. Copyright © 2014 John Wiley \& Sons, Ltd.}, language = {en} } @article{WardoyoNoorElbersetal.2020, author = {Wardoyo, Arinto Y.P. and Noor, Johan A.E. and Elbers, Gereon and Schmitz, Sandra and Flaig, Sascha T. and Budianto, Arif}, title = {Characterizing volcanic ash elements from the 2015 eruptions of bromo and raung volcanoes, Indonesia}, series = {Polish Journal of Environmental Studies}, volume = {29}, journal = {Polish Journal of Environmental Studies}, number = {2}, publisher = {HARD}, address = {Olsztyn}, issn = {2083-5906}, doi = {10.15244/pjoes/99101}, pages = {1899 -- 1907}, year = {2020}, abstract = {The volcanic eruptions of Mt. Bromo and Mt. Raung in East Java, Indonesia, in 2015 perturbed volcanic materials and affected surface-layer air quality at surrounding locations. During the episodes, the volcanic ash from the eruptions influenced visibility, traffic accidents, flight schedules, and human health. In this research, the volcanic ash particles were collected and characterized by relying on the detail of physical observation. We performed an assessment of the volcanic ash elements to characterize the volcanic ash using two different methods which are aqua regia extracts followed by MP-AES and XRF laboratory test of bulk samples. The analysis results showed that the volcanic ash was mixed of many materials, such as Al, Si, P, K, Ca, Ti, V, Cr, Mn, Fe, Ni, and others. Fe, Si, Ca, and Al were found as the major elements, while the others were the trace elements Ba, Cr, Cu, Mn, P, Mn, Ni, Zn, Sb, Sr, and V with the minor concentrations. XRF analyses showed that Fe dominated the elements of the volcanic ash. The XRF analysis showed that Fe was at 35.40\% in Bromo and 43.00\% in Raung of the detected elements in bulk material. The results of aqua regia extracts analyzed by MP-AES were 1.80\% and 1.70\% of Fe element for Bromo and Raung volcanoes, respectively.}, language = {en} } @article{WarerkarSchmitzGoettscheetal.2011, author = {Warerkar, Shashikant and Schmitz, Stefan and G{\"o}ttsche, Joachim and Hoffschmidt, Bernhard and Reißel, Martin and Tamme, Rainer}, title = {Air-Sand Heat Exchanger for High-Temperature Storage}, series = {Journal of Solar Energy Engineering. 133 (2011), H. 2}, journal = {Journal of Solar Energy Engineering. 133 (2011), H. 2}, publisher = {ASME}, address = {New York}, isbn = {0199-6231}, pages = {021010}, year = {2011}, language = {en} } @article{WarmerWagnerSchoeningetal.2015, author = {Warmer, Johannes and Wagner, Patrick and Sch{\"o}ning, Michael Josef and Kaul, Peter}, title = {Detection of triacetone triperoxide using temperature cycled metal-oxide semiconductor gas sensors}, series = {Physica status solidi (a)}, volume = {212}, journal = {Physica status solidi (a)}, number = {6}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.201431882}, pages = {1289 -- 1298}, year = {2015}, language = {en} } @article{WeberBhujuChandraetal.2004, author = {Weber, Hans-Joachim and Bhuju, S. and Chandra, S. and Mo, X.}, title = {Fabrication of biodegradable nanofibers for tubular scaffolds in regenerative medicine / Weber, H.-J. ; Bhuju, S. ; Chandra, S. ; Mo, X.}, series = {Biomedizinische Technik. 49 (2004), H. Erg.-Bd. 2, Teil 2}, journal = {Biomedizinische Technik. 49 (2004), H. Erg.-Bd. 2, Teil 2}, pages = {1016 -- 1017}, year = {2004}, language = {en} } @article{WeberHekmatZimmermannetal.2004, author = {Weber, Hans-Joachim and Hekmat, K. and Zimmermann, T. and Kampe, S.}, title = {Impact of tranexamic acid vs. aprotinin on blood loss and transfusion requirements after cardiopulmonary bypass: a prospective, randomised, double-blind trial / Hekmat, K. ; Zimmermann, T. ; Kampe, S. ; Kasper, S. M. ; Weber, H. J. ; Geissler, H. J. ; Meh}, series = {Current Medical Research and Opinion. 20 (2004), H. 1}, journal = {Current Medical Research and Opinion. 20 (2004), H. 1}, isbn = {0300-7995}, pages = {121 -- 126}, year = {2004}, language = {en} } @article{WeberLacoKunetal.2009, author = {Weber, Hans-Joachim and Laco, Filip and Kun, Ma and Ramakrishna, S.}, title = {The dose effect of human bone marrow-derived mesenchymal stem cells on epidermal development in organotypic co-culture / Laco, Filip ; Kun, Ma ; Weber, Hans Joachim ; Ramakrishna, S. ; Chan, Casey K.}, series = {Journal of Dermatological Science. 55 (2009), H. 3}, journal = {Journal of Dermatological Science. 55 (2009), H. 3}, isbn = {0923-1811}, pages = {150 -- 160}, year = {2009}, language = {en} } @article{WeberMo2004, author = {Weber, Hans-Joachim and Mo, Xiumei}, title = {Electrospinning P(LLA-CL) nanofiber: a tubular scaffold fabrication with circumferential alignment / Xiumei Mo, Hans-Joachim Weber}, series = {Contributions from 6th Austrian Polymer Meeting : Vienna, Austria, September 15 - 17, 2003 / Symposium ed.: W. H. Binder}, journal = {Contributions from 6th Austrian Polymer Meeting : Vienna, Austria, September 15 - 17, 2003 / Symposium ed.: W. H. Binder}, publisher = {Wiley-VCH}, address = {Weinheim}, pages = {413 -- 416}, year = {2004}, language = {en} } @article{WeberMoChen2007, author = {Weber, Hans-Joachim and Mo, Xiumei and Chen, Zonggang}, title = {Electrospun nanofibers of collagen-chitosan and P(LLA-CL) for tissue engineering / Mo Xiumei, Chen Zonggang, Hans J. Weber}, series = {Frontiers of materials science in China. 1 (2007), H. 1}, journal = {Frontiers of materials science in China. 1 (2007), H. 1}, publisher = {-}, isbn = {1673-7377}, pages = {20 -- 23}, year = {2007}, language = {en} } @article{WeberMoRamakrishna2006, author = {Weber, Hans-Joachim and Mo, Xiumei and Ramakrishna, S.}, title = {PCL-PGLA composite tubular scaffold preparation and biocompatibility investigation / X. Mo, H.-J. Weber, S. Ramakrishna}, series = {The International journal of artificial organs. 29 (2006), H. 8}, journal = {The International journal of artificial organs. 29 (2006), H. 8}, publisher = {-}, pages = {790 -- 799}, year = {2006}, language = {en} } @article{WeberArentMuenchetal.2016, author = {Weber, Tobias and Arent, Jan-Christoph and M{\"u}nch, Lukas and Duhovic, Miro and Balvers, Johannes M.}, title = {A fast method for the generation of boundary conditions for thermal autoclave simulation}, series = {Composites Part A}, volume = {88}, journal = {Composites Part A}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1359-835X}, doi = {10.1016/j.compositesa.2016.05.036}, pages = {216 -- 225}, year = {2016}, abstract = {Manufacturing process simulation enables the evaluation and improvement of autoclave mold concepts early in the design phase. To achieve a high part quality at low cycle times, the thermal behavior of the autoclave mold can be investigated by means of simulations. Most challenging for such a simulation is the generation of necessary boundary conditions. Heat-up and temperature distribution in an autoclave mold are governed by flow phenomena, tooling material and shape, position within the autoclave, and the chosen autoclave cycle. This paper identifies and summarizes the most important factors influencing mold heat-up and how they can be introduced into a thermal simulation. Thermal measurements are used to quantify the impact of the various parameters. Finally, the gained knowledge is applied to develop a semi-empirical approach for boundary condition estimation that enables a simple and fast thermal simulation of the autoclave curing process with reasonably high accuracy for tooling optimization.}, language = {en} } @article{WeberArentSteffenetal.2017, author = {Weber, Tobias and Arent, Jan-Christoph and Steffen, Lucas and Balvers, Johannes M. and Duhovic, Miro}, title = {Thermal optimization of composite autoclave molds using the shift factor approach for boundary condition estimation}, series = {Journal of Composite Materials}, volume = {51}, journal = {Journal of Composite Materials}, number = {12}, publisher = {Sage}, address = {London}, issn = {1530-793X}, doi = {10.1177/0021998317699868}, pages = {1753 -- 1767}, year = {2017}, language = {en} } @article{WeberEnglhardArentetal.2019, author = {Weber, Tobias and Englhard, Markus and Arent, Jan-Christoph and Hausmann, Joachim}, title = {An experimental characterization of wrinkling generated during prepreg autoclave manufacturing using caul plates}, series = {Journal of Composite Materials}, volume = {53}, journal = {Journal of Composite Materials}, number = {26-27}, issn = {1530-793X}, doi = {10.1177/0021998319846556}, pages = {3757 -- 3773}, year = {2019}, language = {en} } @article{WeberRuffStahl2017, author = {Weber, Tobias and Ruff-Stahl, Hans-Joachim K.}, title = {Advances in Composite Manufacturing of Helicopter Parts}, series = {International Journal of Aviation, Aeronautics, and Aerospace}, volume = {4}, journal = {International Journal of Aviation, Aeronautics, and Aerospace}, number = {1}, issn = {2374-6793}, doi = {10.15394/ijaaa.2017.1153}, year = {2017}, language = {en} } @article{WeckesserGriessmeierSchmidtetal.1998, author = {Weckesser, Martin and Grießmeier, Martin and Schmidt, Daniela and Sonnenberg, Frank and Ziemons, Karl and Kemna, Lars and Holschbach, Marcus and Langen, Karl-J. and M{\"u}ller-G{\"a}rtner, Hans-W.}, title = {Iodine-123 α-methyl tyrosine single-photon emission tomography of cerebral gliomas: standardised evaluation of tumour uptake and extent}, series = {European Journal of Nuclear Medicine}, volume = {25}, journal = {European Journal of Nuclear Medicine}, number = {2}, isbn = {1619-7089}, pages = {150 -- 156}, year = {1998}, abstract = {Single-photon emission tomography (SPET) with the amino acid analogue l-3-[123I]iodo-α-methyl tyrosine (IMT) is helpful in the diagnosis and monitoring of cerebral gliomas. Radiolabelled amino acids seem to reflect tumour infiltration more specifically than conventional methods like magnetic resonance imaging and computed tomography. Automatic tumour delineation based on maximal tumour uptake may cause an overestimation of mean tumour uptake and an underestimation of tumour extension in tumours with circumscribed peaks. The aim of this study was to develop a program for tumour delineation and calculation of mean tumour uptake which takes into account the mean background activity and is thus optimised to the problem of tumour definition in IMT SPET. Using the frequency distribution of pixel intensities of the tomograms a program was developed which automatically detects a reference brain region and draws an isocontour region around the tumour taking into account mean brain radioactivity. Tumour area and tumour/brain ratios were calculated. A three-compartment phantom was simulated to test the program. The program was applied to IMT SPET studies of 20 patients with cerebral gliomas and was compared to the results of manual analysis by three different investigators. Activity ratios and chamber extension of the phantom were correctly calculated by the automatic analysis. A method based on image maxima alone failed to determine chamber extension correctly. Manual region of interest analysis in patient studies resulted in a mean inter-observer standard deviation of 8.7\%±6.1\% (range 2.7\%-25.0\%). The mean value of the results of the manual analysis showed a significant correlation to the results of the automatic analysis (r = 0.91, P<0.0001 for the uptake ratio; r = 0.87, P<0.0001 for the tumour area). We conclude that the algorithm proposed simplifies the calculation of uptake ratios and may be used for observer-independent evaluation of IMT SPET studies. Three-dimensional tumour recognition and transfer to co-registered morphological images based on this program may be useful for the planning of surgical and radiation treatment.}, language = {en} } @article{WeckesserHufnagelZiemonsetal.1997, author = {Weckesser, Matthias and Hufnagel, Andreas and Ziemons, Karl and Grießmeier, Martin and Sonnenberg, Frank and Hackl{\"a}nder, Thomas and Langen, Karl-J. and Holschbach, Markus and Elger, Christian E. and M{\"u}ller-G{\"a}rtner, Hans-W.}, title = {Effect of partial volume correction on muscarinic cholinergic receptor imaging with single-photon emission tomography in patients with temporal lobe epilepsy}, series = {European Journal of Nuclear Medicine}, volume = {24}, journal = {European Journal of Nuclear Medicine}, number = {9}, isbn = {1619-7089}, pages = {1156 -- 1161}, year = {1997}, abstract = {Animal experiments and preliminary results in humans have indicated alterations of hippocampal muscarinic acetylcholine receptors (mAChR) in temporal lobe epilepsy. Patients with temporal lobe epilepsy often present with a reduction in hippocampal volume. The aim of this study was to investigate the influence of hippocampal atrophy on the quantification of mAChR with single photon emission tomography (SPET) in patients with temporal lobe epilepsy. Cerebral uptake of the muscarinic cholinergic antagonist [123I]4-iododexetimide (IDex) was investigated by SPET in patients suffering from temporal lobe epilepsy of unilateral (n=6) or predominantly unilateral (n=1) onset. Regions of interest were drawn on co-registered magnetic resonance images. Hippocampal volume was determined in these regions and was used to correct the SPET results for partial volume effects. A ratio of hippocampal IDex binding on the affected side to that on the unaffected side was used to detect changes in muscarinic cholinergic receptor density. Before partial volume correction a decrease in hippocampal IDex binding on the focus side was found in each patient. After partial volume no convincing differences remained. Our results indicate that the reduction in hippocampal IDex binding in patients with epilepsy is due to a decrease in hippocampal volume rather than to a decrease in receptor concentration.}, language = {en} } @article{WedrowskiBruyndonckxTavernieretal.2009, author = {Wedrowski, M. and Bruyndonckx, P. and Tavernier, S. and Zhi, L. and Dang, J. and Mendes, P. R. and Perez, J. M. and Ziemons, Karl}, title = {Robustness of neural networks algorithm for gamma detection in monolithic block detector, positron emission tomography}, series = {2009 IEEE Nuclear Science Symposium Conference Record (NSS/MIC)}, journal = {2009 IEEE Nuclear Science Symposium Conference Record (NSS/MIC)}, isbn = {1082-3654}, pages = {2625 -- 2628}, year = {2009}, abstract = {The monolithic scintillator block approach for gamma detection in the Positron Emission Tomography (PET) avoids estimating Depth of Interaction (DOI), reduces dead zones in detector and diminishes costs of detector production. Neural Networks (NN) are very efficient to determine the entrance point of a gamma incident on a scintillator block. This paper presents results on the robustness of the spatial resolution as a function of the random fraction in the data, temperature and HV fluctuations. This is important when implementing the method in a real scanner. Measurements were done with two Hamamatsu S8550 APD arrays, glued on a 20 {\~A}— 20 {\~A}— 10 mm3 monolithic LSO crystal block.}, language = {en} } @article{WeemstraEilmannSassKlaassenetal.2013, author = {Weemstra, Monique and Eilmann, Britta and Sass-Klaassen, Ute G. W. and Sterck, Frank J.}, title = {Summer droughts limit tree growth across 10 temperate species on a productive forest site}, series = {Forest Ecology and Management}, volume = {2013}, journal = {Forest Ecology and Management}, number = {306}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0378-1127 (Print)}, doi = {doi:10.1016/j.foreco.2013.06.007}, pages = {142 -- 149}, year = {2013}, language = {en} } @article{WegmannHacklStaatetal.2016, author = {Wegmann, Kilian and Hackl, Michael and Staat, Manfred and Mayer, Katharina and M{\"u}ller, Lars-Peter}, title = {Double plate osteosynthesis of proximal ulna fractures: biomechanical and clinical results}, series = {Knee surgery, sports traumatology, arthroscopy}, volume = {Volume 24}, journal = {Knee surgery, sports traumatology, arthroscopy}, number = {Supplement 1}, publisher = {Springer}, address = {Berlin}, issn = {0942-2056}, doi = {10.1007/s00167-016-4079-0}, pages = {58 -- 59}, year = {2016}, abstract = {While plate fixation of proximal ulna fractures might lead to superior clinical results compared to tension band wiring, regular plates represent an established risk factor for wound complications. The olecranon double plates (Medartis, Basel, CH) might decrease complications related to the osteosynthesis because of their low profile and better anatomical fit. This study aimed to evaluate the biomechanical performance and clinical results of the olecranon double plates.}, language = {en} } @article{WegnervonArxSassKlaassenetal.2013, author = {Wegner, Lena and von Arx, Georg and Sass-Klaassen, Ute G. W. and Eilmann, Britta}, title = {ROXAS - an efficient and accurate tool to detect vessels in diffuse-porous species}, series = {IAWA Journal / International Association of Wood Anatomists}, volume = {34}, journal = {IAWA Journal / International Association of Wood Anatomists}, number = {4}, publisher = {Brill}, address = {Leiden}, issn = {0928-1541 (Print)}, doi = {10.1163/22941932-00000034}, pages = {425 -- 432}, year = {2013}, language = {en} } @article{Weigand1992, author = {Weigand, Christoph}, title = {Economic Machine Adjustment in the Case of Product Screening .E.v.Collani, Ch. Weigand}, series = {Statistical Papers. 33 (1992)}, journal = {Statistical Papers. 33 (1992)}, pages = {171 -- 184}, year = {1992}, language = {en} } @article{Weigand2009, author = {Weigand, Christoph}, title = {Defining Precisions for Reliable Measurement and Estimation Procedures}, series = {Economic Quality Control. 24 (2009), H. 1}, journal = {Economic Quality Control. 24 (2009), H. 1}, publisher = {De Gruyter}, address = {Berlin}, isbn = {0940-5151}, pages = {5 -- 33}, year = {2009}, language = {en} } @article{Weigand2003, author = {Weigand, Christoph}, title = {Economically Optimal Inspection Policy with Geometrical Adaption}, series = {Journal of Applied Statistics. 30 (2003), H. 5}, journal = {Journal of Applied Statistics. 30 (2003), H. 5}, isbn = {0266-4763}, pages = {555 -- 569}, year = {2003}, language = {en} } @article{Weigand2001, author = {Weigand, Christoph}, title = {Economically Optimal Inspection Policy with Arithmetical Adaption}, series = {Applied stochastic models and data analysis / [10th International Symposium on Applied Stochastic Models and Analysis, June 12-15 2001, Universit{\´e} Technologique de Compi{\`e}gne] ; editors G{\´e}rard Govaert, Jacques Janssen, Nikolaos Limnios.}, journal = {Applied stochastic models and data analysis / [10th International Symposium on Applied Stochastic Models and Analysis, June 12-15 2001, Universit{\´e} Technologique de Compi{\`e}gne] ; editors G{\´e}rard Govaert, Jacques Janssen, Nikolaos Limnios.}, publisher = {Universit{\´e} Technologique de Compi{\`e}gne}, address = {Compi{\`e}gne}, pages = {1010 -- 1015}, year = {2001}, language = {en} } @article{Weigand1994, author = {Weigand, Christoph}, title = {Optimal Production Schedule for a K Products Single Machine Problem}, series = {Economic Quality Control. 9 (1994)}, journal = {Economic Quality Control. 9 (1994)}, isbn = {0940-5151}, pages = {91 -- 101}, year = {1994}, language = {en} } @article{Weigand2012, author = {Weigand, Christoph}, title = {Statistical Tests Based on Reliability and Precision}, series = {Economic Quality Control : EQC ; international journal for quality and reliability}, volume = {27}, journal = {Economic Quality Control : EQC ; international journal for quality and reliability}, number = {1}, publisher = {De Gruyter}, address = {Berlin}, issn = {1869-6147}, doi = {10.1515/eqc-2012-0002}, pages = {43 -- 64}, year = {2012}, abstract = {The construction of a statistical test is investigated which is based only on "reliability" and "precision" as quality criteria. The reliability of a statistical test is quantifiedin a straightforward way by the probability that the decision of the test is correct. However, the quantification of the precision of a statistical test is not at all evident. Thereforethe paper presents and discusses several approaches. Moreover the distinction of "nullhypothesis" and "alternative hypothesis" is not necessary any longer.}, language = {en} } @article{Weigand1991, author = {Weigand, Christoph}, title = {A Solution to the Scheduling Problem Taking into Account Quality}, series = {Operations research '91 : extended abstracts of the 16th Symposium on Operations Research held at the University of Trier at September 9 - 11, 1991 / [GM{\"O}OR]. Peter Gritzmann ... (eds.)}, journal = {Operations research '91 : extended abstracts of the 16th Symposium on Operations Research held at the University of Trier at September 9 - 11, 1991 / [GM{\"O}OR]. Peter Gritzmann ... (eds.)}, publisher = {Physica-Verl.}, address = {Heidelberg}, isbn = {3790806080}, pages = {373 -- 375}, year = {1991}, language = {en} } @article{Weigand2000, author = {Weigand, Christoph}, title = {Economically Optimal Adaptive Inspection Policies}, series = {Economic Quality Control. 15 (2000), H. 1/2}, journal = {Economic Quality Control. 15 (2000), H. 1/2}, isbn = {0940-5151}, pages = {55 -- 77}, year = {2000}, language = {en} } @article{Weigand1993, author = {Weigand, Christoph}, title = {On the Effects of SPC on Production Time}, series = {Economic Quality Control. 8 (1993)}, journal = {Economic Quality Control. 8 (1993)}, isbn = {0940-5151}, pages = {23 -- 61}, year = {1993}, language = {en} } @article{Weigand2003, author = {Weigand, Christoph}, title = {Technically Optimal Inspection Policy with Arithmetical Adaption}, series = {IMA Journal of Management Mathematics. 14 (2003), H. 4}, journal = {IMA Journal of Management Mathematics. 14 (2003), H. 4}, isbn = {1471-678X}, pages = {357 -- 371}, year = {2003}, language = {en} } @article{Weigand1990, author = {Weigand, Christoph}, title = {Optimal Adjustment Policies}, series = {Proceedings of the First Ume{\aa}-W{\"u}rzburg Conference in Statistics : Kronlund Conference Center and University of Ume{\aa}, September 10 - 14, 1990 / ed. by Kurt Br{\"a}nn{\"a}s}, journal = {Proceedings of the First Ume{\aa}-W{\"u}rzburg Conference in Statistics : Kronlund Conference Center and University of Ume{\aa}, September 10 - 14, 1990 / ed. by Kurt Br{\"a}nn{\"a}s}, publisher = {Univ. of Ume{\aa}}, address = {Ume{\aa}}, isbn = {91-7174-564-5}, pages = {147 -- 158}, year = {1990}, language = {en} } @article{Weigand1992, author = {Weigand, Christoph}, title = {A new Approach for Optimal Control of a Production process}, series = {Economic Quality Control. 7 (1992)}, journal = {Economic Quality Control. 7 (1992)}, isbn = {0940-5151}, pages = {225 -- 251}, year = {1992}, language = {en} } @article{WeigandCollaniSaniga1994, author = {Weigand, Christoph and Collani, E. v. and Saniga, E.M.}, title = {Economic Adjustment Design for -Control Charts. E.v.Collani, E.M. Saniga, Ch. Weigand}, series = {IIE Transactions / Institute of Industrial Engineers. 26 (1994), H. 6}, journal = {IIE Transactions / Institute of Industrial Engineers. 26 (1994), H. 6}, isbn = {0569-5554}, year = {1994}, language = {en} } @article{WeldenPoghossianVahidpouretal.2022, author = {Welden, Melanie and Poghossian, Arshak and Vahidpour, Farnoosh and Wendlandt, Tim and Keusgen, Michael and Wege, Christina and Sch{\"o}ning, Michael Josef}, title = {Towards multi-analyte detection with field-effect capacitors modified with tobacco mosaic virus bioparticles as enzyme nanocarriers}, series = {Biosensors}, volume = {12}, journal = {Biosensors}, number = {1}, publisher = {MDPI}, address = {Basel}, issn = {2079-6374}, doi = {10.3390/bios12010043}, pages = {Artikel 43}, year = {2022}, abstract = {Utilizing an appropriate enzyme immobilization strategy is crucial for designing enzyme-based biosensors. Plant virus-like particles represent ideal nanoscaffolds for an extremely dense and precise immobilization of enzymes, due to their regular shape, high surface-to-volume ratio and high density of surface binding sites. In the present work, tobacco mosaic virus (TMV) particles were applied for the co-immobilization of penicillinase and urease onto the gate surface of a field-effect electrolyte-insulator-semiconductor capacitor (EISCAP) with a p-Si-SiO₂-Ta₂O₅ layer structure for the sequential detection of penicillin and urea. The TMV-assisted bi-enzyme EISCAP biosensor exhibited a high urea and penicillin sensitivity of 54 and 85 mV/dec, respectively, in the concentration range of 0.1-3 mM. For comparison, the characteristics of single-enzyme EISCAP biosensors modified with TMV particles immobilized with either penicillinase or urease were also investigated. The surface morphology of the TMV-modified Ta₂O₅-gate was analyzed by scanning electron microscopy. Additionally, the bi-enzyme EISCAP was applied to mimic an XOR (Exclusive OR) enzyme logic gate.}, language = {en} } @article{WeldenSeverinsPoghossianetal.2022, author = {Welden, Melanie and Severins, Robin and Poghossian, Arshak and Wege, Christina and Bongaerts, Johannes and Siegert, Petra and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Detection of acetoin and diacetyl by a tobacco mosaic virus-assisted field-effect biosensor}, series = {Chemosensors}, volume = {10}, journal = {Chemosensors}, number = {6}, publisher = {MDPI}, address = {Basel}, issn = {2227-9040}, doi = {10.3390/chemosensors10060218}, pages = {Artikel 218}, year = {2022}, abstract = {Acetoin and diacetyl have a major impact on the flavor of alcoholic beverages such as wine or beer. Therefore, their measurement is important during the fermentation process. Until now, gas chromatographic techniques have typically been applied; however, these require expensive laboratory equipment and trained staff, and do not allow for online monitoring. In this work, a capacitive electrolyte-insulator-semiconductor sensor modified with tobacco mosaic virus (TMV) particles as enzyme nanocarriers for the detection of acetoin and diacetyl is presented. The enzyme acetoin reductase from Alkalihalobacillus clausii DSM 8716ᵀ is immobilized via biotin-streptavidin affinity, binding to the surface of the TMV particles. The TMV-assisted biosensor is electrochemically characterized by means of leakage-current, capacitance-voltage, and constant capacitance measurements. In this paper, the novel biosensor is studied regarding its sensitivity and long-term stability in buffer solution. Moreover, the TMV-assisted capacitive field-effect sensor is applied for the detection of diacetyl for the first time. The measurement of acetoin and diacetyl with the same sensor setup is demonstrated. Finally, the successive detection of acetoin and diacetyl in buffer and in diluted beer is studied by tuning the sensitivity of the biosensor using the pH value of the measurement solution.}, language = {en} } @article{WeldenJablonskiWegeetal.2021, author = {Welden, Rene and Jablonski, Melanie and Wege, Christina and Keusgen, Michael and Wagner, Patrick Hermann and Wagner, Torsten and Sch{\"o}ning, Michael Josef}, title = {Light-Addressable Actuator-Sensor Platform for Monitoring and Manipulation of pH Gradients in Microfluidics: A Case Study with the Enzyme Penicillinase}, series = {Biosensors}, volume = {11}, journal = {Biosensors}, number = {6}, publisher = {MDPI}, address = {Basel}, issn = {2079-6374}, doi = {10.3390/bios11060171}, pages = {Artikel 171}, year = {2021}, abstract = {The feasibility of light-addressed detection and manipulation of pH gradients inside an electrochemical microfluidic cell was studied. Local pH changes, induced by a light-addressable electrode (LAE), were detected using a light-addressable potentiometric sensor (LAPS) with different measurement modes representing an actuator-sensor system. Biosensor functionality was examined depending on locally induced pH gradients with the help of the model enzyme penicillinase, which had been immobilized in the microfluidic channel. The surface morphology of the LAE and enzyme-functionalized LAPS was studied by scanning electron microscopy. Furthermore, the penicillin sensitivity of the LAPS inside the microfluidic channel was determined with regard to the analyte's pH influence on the enzymatic reaction rate. In a final experiment, the LAE-controlled pH inhibition of the enzyme activity was monitored by the LAPS.}, language = {en} } @article{WeldenNagamineKomesuWagneretal.2021, author = {Welden, Rene and Nagamine Komesu, Cindy A. and Wagner, Patrick H. and Sch{\"o}ning, Michael Josef and Wagner, Torsten}, title = {Photoelectrochemical enzymatic penicillin biosensor: A proof-of-concept experiment}, series = {Electrochemical Science Advances}, volume = {2}, journal = {Electrochemical Science Advances}, number = {4}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {2698-5977}, doi = {10.1002/elsa.202100131}, pages = {1 -- 5}, year = {2021}, abstract = {Photoelectrochemical (PEC) biosensors are a rather novel type of biosensors thatutilizelighttoprovideinformationaboutthecompositionofananalyte,enablinglight-controlled multi-analyte measurements. For enzymatic PEC biosensors,amperometric detection principles are already known in the literature. In con-trast, there is only a little information on H+-ion sensitive PEC biosensors. Inthis work, we demonstrate the detection of H+ions emerged by H+-generatingenzymes, exemplarily demonstrated with penicillinase as a model enzyme on atitanium dioxide photoanode. First, we describe the pH sensitivity of the sensorand study possible photoelectrocatalytic reactions with penicillin. Second, weshow the enzymatic PEC detection of penicillin.}, language = {en} } @article{WeldenSchejaSchoeningetal.2018, author = {Welden, Rene and Scheja, Sabrina and Sch{\"o}ning, Michael Josef and Wagner, Patrick and Wagner, Torsten}, title = {Electrochemical Evaluation of Light-Addressable Electrodes Based on TiO2 for the Integration in Lab-on-Chip Systems}, series = {physica status solidi a : applications and materials sciences}, volume = {215}, journal = {physica status solidi a : applications and materials sciences}, number = {15}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.201800150}, pages = {Article number 1800150}, year = {2018}, abstract = {In lab-on-chip systems, electrodes are important for the manipulation (e.g., cell stimulation, electrolysis) within such systems. An alternative to commonly used electrode structures can be a light-addressable electrode. Here, due to the photoelectric effect, the conducting area can be adjusted by modification of the illumination area which enables a flexible control of the electrode. In this work, titanium dioxide based light-addressable electrodes are fabricated by a sol-gel technique and a spin-coating process, to deposit a thin film on a fluorine-doped tin oxide glass. To characterize the fabricated electrodes, the thickness, and morphological structure are measured by a profilometer and a scanning electron microscope. For the electrochemical behavior, the dark current and the photocurrent are determined for various film thicknesses. For the spatial resolution behavior, the dependency of the photocurrent while changing the area of the illuminated area is studied. Furthermore, the addressing of single fluid compartments in a three-chamber system, which is added to the electrode, is demonstrated.}, language = {en} } @article{WeldenSchoeningWagneretal.2020, author = {Welden, Rene and Sch{\"o}ning, Michael Josef and Wagner, Patrick H. and Wagner, Torsten}, title = {Light-Addressable Electrodes for Dynamic and Flexible Addressing of Biological Systems and Electrochemical Reactions}, series = {Sensors}, volume = {20}, journal = {Sensors}, number = {6}, publisher = {MDPI}, address = {Basel}, issn = {1424-8220}, doi = {10.3390/s20061680}, pages = {Artikel 1680}, year = {2020}, abstract = {In this review article, we are going to present an overview on possible applications of light-addressable electrodes (LAE) as actuator/manipulation devices besides classical electrode structures. For LAEs, the electrode material consists of a semiconductor. Illumination with a light source with the appropiate wavelength leads to the generation of electron-hole pairs which can be utilized for further photoelectrochemical reaction. Due to recent progress in light-projection technologies, highly dynamic and flexible illumination patterns can be generated, opening new possibilities for light-addressable electrodes. A short introduction on semiconductor-electrolyte interfaces with light stimulation is given together with electrode-design approaches. Towards applications, the stimulation of cells with different electrode materials and fabrication designs is explained, followed by analyte-manipulation strategies and spatially resolved photoelectrochemical deposition of different material types.}, language = {en} } @article{WemhoenerHafnerSchwarzer2000, author = {Wemh{\"o}ner, Carsten and Hafner, Bernd and Schwarzer, Klemens}, title = {Simulation of solar thermal systems with CARNOT blockset in the environment MATLAB-Simulink}, pages = {1 -- 6}, year = {2000}, language = {en} } @article{WendlandtKochBritzetal.2023, author = {Wendlandt, Tim and Koch, Claudia and Britz, Beate and Liedek, Anke and Schmidt, Nora and Werner, Stefan and Gleba, Yuri and Vahidpour, Farnoosh and Welden, Melanie and Poghossian, Arshak and Sch{\"o}ning, Michael Josef}, title = {Facile Purification and Use of Tobamoviral Nanocarriers for Antibody-Mediated Display of a Two-Enzyme System}, series = {Viruses}, volume = {9}, journal = {Viruses}, number = {15}, publisher = {MDPI}, address = {Basel}, issn = {1999-4915}, doi = {doi.org/10.3390/v15091951}, pages = {Artikel 1951}, year = {2023}, abstract = {Immunosorbent turnip vein clearing virus (TVCV) particles displaying the IgG-binding domains D and E of Staphylococcus aureus protein A (PA) on every coat protein (CP) subunit (TVCVPA) were purified from plants via optimized and new protocols. The latter used polyethylene glycol (PEG) raw precipitates, from which virions were selectively re-solubilized in reverse PEG concentration gradients. This procedure improved the integrity of both TVCVPA and the wild-type subgroup 3 tobamovirus. TVCVPA could be loaded with more than 500 IgGs per virion, which mediated the immunocapture of fluorescent dyes, GFP, and active enzymes. Bi-enzyme ensembles of cooperating glucose oxidase and horseradish peroxidase were tethered together on the TVCVPA carriers via a single antibody type, with one enzyme conjugated chemically to its Fc region, and the other one bound as a target, yielding synthetic multi-enzyme complexes. In microtiter plates, the TVCVPA-displayed sugar-sensing system possessed a considerably increased reusability upon repeated testing, compared to the IgG-bound enzyme pair in the absence of the virus. A high coverage of the viral adapters was also achieved on Ta2O5 sensor chip surfaces coated with a polyelectrolyte interlayer, as a prerequisite for durable TVCVPA-assisted electrochemical biosensing via modularly IgG-assembled sensor enzymes.}, language = {en} } @article{WerfelGuenthnerHapfelmeieretal.2022, author = {Werfel, Stanislas and G{\"u}nthner, Roman and Hapfelmeier, Alexander and Hanssen, Henner and Kotliar, Konstantin and Heemann, Uwe and Schmaderer, Christoph}, title = {Identification of cardiovascular high-risk groups from dynamic retinal vessel signals using untargeted machine learning}, series = {Cardiovascular Research}, volume = {118}, journal = {Cardiovascular Research}, number = {2}, editor = {Guzik, Tomasz J.}, publisher = {Oxford University Press}, address = {Oxford}, issn = {0008-6363}, doi = {10.1093/cvr/cvab040}, pages = {612 -- 621}, year = {2022}, abstract = {Dynamic retinal vessel analysis (DVA) provides a non-invasive way to assess microvascular function in patients and potentially to improve predictions of individual cardiovascular (CV) risk. The aim of our study was to use untargeted machine learning on DVA in order to improve CV mortality prediction and identify corresponding response alterations.}, language = {en} } @article{WerkhausenAlbrachtCroninetal.2018, author = {Werkhausen, Amelie and Albracht, Kirsten and Cronin, Neil J and Paulsen, G{\o}ran and Bojsen-M{\o}ller, Jens and Seynnes, Olivier R}, title = {Effect of training-induced changes in achilles tendon stiffness on muscle-tendon behavior during landing}, series = {Frontiers in physiology}, journal = {Frontiers in physiology}, number = {9}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1664-042X}, doi = {10.3389/fphys.2018.00794}, pages = {11 Seiten}, year = {2018}, abstract = {During rapid deceleration of the body, tendons buffer part of the elongation of the muscle-tendon unit (MTU), enabling safe energy dissipation via eccentric muscle contraction. Yet, the influence of changes in tendon stiffness within the physiological range upon these lengthening contractions is unknown. This study aimed to examine the effect of training-induced stiffening of the Achilles tendon on triceps surae muscle-tendon behavior during a landing task. Twenty-one male subjects were assigned to either a 10-week resistance-training program consisting of single-leg isometric plantarflexion (n = 11) or to a non-training control group (n = 10). Before and after the training period, plantarflexion force, peak Achilles tendon strain and stiffness were measured during isometric contractions, using a combination of dynamometry, ultrasound and kinematics data. Additionally, testing included a step-landing task, during which joint mechanics and lengths of gastrocnemius and soleus fascicles, Achilles tendon, and MTU were determined using synchronized ultrasound, kinematics and kinetics data collection. After training, plantarflexion strength and Achilles tendon stiffness increased (15 and 18\%, respectively), and tendon strain during landing remained similar. Likewise, lengthening and negative work produced by the gastrocnemius MTU did not change detectably. However, in the training group, gastrocnemius fascicle length was offset (8\%) to a longer length at touch down and, surprisingly, fascicle lengthening and velocity were reduced by 27 and 21\%, respectively. These changes were not observed for soleus fascicles when accounting for variation in task execution between tests. These results indicate that a training-induced increase in tendon stiffness does not noticeably affect the buffering action of the tendon when the MTU is rapidly stretched. Reductions in gastrocnemius fascicle lengthening and lengthening velocity during landing occurred independently from tendon strain. Future studies are required to provide insight into the mechanisms underpinning these observations and their influence on energy dissipation.}, language = {en} } @article{WerkhausenAlbrachtCroninetal.2017, author = {Werkhausen, Amelie and Albracht, Kirsten and Cronin, Neil J. and Meier, Rahel and Mojsen-Moeller, Jens and Seynnes, Olivier R.}, title = {Modulation of muscle-tendon interaction in the human triceps surae during an energy dissipation task}, series = {Journal of Experimental Biology}, volume = {220}, journal = {Journal of Experimental Biology}, number = {22}, issn = {0022-0949}, doi = {10.1242/jeb.164111}, pages = {4141 -- 4149}, year = {2017}, language = {en} }