@article{AlKaidyKuthanHeringetal.2016, author = {Al-Kaidy, Huschyar and Kuthan, Kai and Hering, Thomas and Tippk{\"o}tter, Nils}, title = {Aqueous droplets used as enzymatic microreactors and their electromagnetic actuation}, series = {Journal of Visualized Experiments}, journal = {Journal of Visualized Experiments}, number = {Issue 126}, issn = {1940-087X}, doi = {10.3791/54643}, year = {2016}, abstract = {For the successful implementation of microfluidic reaction systems, such as PCR and electrophoresis, the movement of small liquid volumes is essential. In conventional lab-on-a-chip-platforms, solvents and samples are passed through defined microfluidic channels with complex flow control installations. The droplet actuation platform presented here is a promising alternative. With it, it is possible to move a liquid drop (microreactor) on a planar surface of a reaction platform (lab-in-a-drop). The actuation of microreactors on the hydrophobic surface of the platform is based on the use of magnetic forces acting on the outer shell of the liquid drops which is made of a thin layer of superhydrophobic magnetite particles. The hydrophobic surface of the platform is needed to avoid any contact between the liquid core and the surface to allow a smooth movement of the microreactor. On the platform, one or more microreactors with volumes of 10 µL can be positioned and moved simultaneously. The platform itself consists of a 3 x 3 matrix of electrical double coils which accommodate either neodymium or iron cores. The magnetic field gradients are automatically controlled. By variation of the magnetic field gradients, the microreactors' magnetic hydrophobic shell can be manipulated automatically to move the microreactor or open the shell reversibly. Reactions of substrates and corresponding enzymes can be initiated by merging the microreactors or bringing them into contact with surface immobilized catalysts.}, language = {en} } @article{AlKaidyTippkoetter2016, author = {Al-Kaidy, Huschyar and Tippk{\"o}tter, Nils}, title = {Superparamagnetic hydrophobic particles as shell material for digital microfluidic droplets and proof-of-principle reaction assessments with immobilized laccase}, series = {Engineering in Life Sciences}, volume = {16}, journal = {Engineering in Life Sciences}, number = {3}, publisher = {Wiley-VCH}, address = {Weinheim}, doi = {10.1002/elsc.201400124}, pages = {222 -- 230}, year = {2016}, abstract = {In the field of biotechnology and molecular biology, the use of small liquid volumes has significant advantages. In particular, screening and optimization runs with acceptable amounts of expensive and hardly available catalysts, reagents, or biomolecules are feasible with microfluidic technologies. The presented new microfluidic system is based on the inclusion of small liquid volumes by a protective shell of magnetizable microparticles. Hereby, discrete aqueous microreactor drops with volumes of 1-30 μL can be formed on a simple planar surface. A digital movement and manipulation of the microreactor is performed by overlapping magnetic forces. The magnetic forces are generated by an electrical coil matrix positioned below a glass plate. With the new platform technology, several discrete reaction compartments can be moved simultaneously on one surface. Due to the magnetic fields, the reactors can even be merged to initiate reactions by mixing or positioned above surface-immobilized catalysts and then opened by magnetic force. Comparative synthesis routes of the magnetizable shell particles and superhydrophobic glass slides including their performance and stability with the reaction platform are described. The influence of diffusive mass transport during the catalyzed reaction is discussed by evaluation finite element model of the microreactor. Furthermore, a first model dye reaction of the enzyme laccase has been established.}, language = {en} } @article{AlbannaConzenWeissetal.2016, author = {Albanna, W. and Conzen, C. and Weiss, M. and Clusmann, H. and Fuest, M. and Mueller, M. and Brockmann, M.A. and Vilser, W. and Schmidt-Trucks{\"a}ss, A. and Hoellig, A. and Seiz, M. and Thom{\´e}, C. and Kotliar, Konstantin and Schubert, G.A.}, title = {Retinal Vessel Analysis (RVA) in the context of subarachnoid hemorrhage: A proof of concept study}, series = {PLoS ONE}, volume = {11}, journal = {PLoS ONE}, number = {7}, publisher = {PLOS}, address = {San Francisco}, issn = {1932-6203}, doi = {10.1371/journal.pone.0158781}, pages = {13 Seiten}, year = {2016}, abstract = {Background Timely detection of impending delayed cerebral ischemia after subarachnoid hemorrhage (SAH) is essential to improve outcome, but poses a diagnostic challenge. Retinal vessels as an embryological part of the intracranial vasculature are easily accessible for analysis and may hold the key to a new and non-invasive monitoring technique. This investigation aims to determine the feasibility of standardized retinal vessel analysis (RVA) in the context of SAH. Methods In a prospective pilot study, we performed RVA in six patients awake and cooperative with SAH in the acute phase (day 2-14) and eight patients at the time of follow-up (mean 4.6±1.7months after SAH), and included 33 age-matched healthy controls. Data was acquired using a manoeuvrable Dynamic Vessel Analyzer (Imedos Systems UG, Jena) for examination of retinal vessel dimension and neurovascular coupling. Results Image quality was satisfactory in the majority of cases (93.3\%). In the acute phase after SAH, retinal arteries were significantly dilated when compared to the control group (124.2±4.3MU vs 110.9±11.4MU, p<0.01), a difference that persisted to a lesser extent in the later stage of the disease (122.7±17.2MU, p<0.05). Testing for neurovascular coupling showed a trend towards impaired primary vasodilation and secondary vasoconstriction (p = 0.08, p = 0.09 resp.) initially and partial recovery at the time of follow-up, indicating a relative improvement in a time-dependent fashion. Conclusion RVA is technically feasible in patients with SAH and can detect fluctuations in vessel diameter and autoregulation even in less severely affected patients. Preliminary data suggests potential for RVA as a new and non-invasive tool for advanced SAH monitoring, but clinical relevance and prognostic value will have to be determined in a larger cohort.}, language = {en} } @article{AlbannaConzenWeissetal.2021, author = {Albanna, Walid and Conzen, Catharina and Weiss, Miriam and Seyfried, Katharina and Kotliar, Konstantin and Schmidt, Tobias Philip and Kuerten, David and Hescheler, J{\"u}rgen and Bruecken, Anne and Schmidt-Trucks{\"a}ss, Arno and Neumaier, Felix and Wiesmann, Martin and Clusmann, Hans and Schubert, Gerrit Alexander}, title = {Non-invasive assessment of neurovascular coupling after aneurysmal subarachnoid hemorrhage: a prospective observational trial using retinal vessel analysis}, series = {Frontiers in Neurology}, volume = {12}, journal = {Frontiers in Neurology}, number = {12}, issn = {1664-2295}, doi = {10.3389/fneur.2021.690183}, pages = {1 -- 15}, year = {2021}, abstract = {Delayed cerebral ischemia (DCI) is a common complication after aneurysmal subarachnoid hemorrhage (aSAH) and can lead to infarction and poor clinical outcome. The underlying mechanisms are still incompletely understood, but animal models indicate that vasoactive metabolites and inflammatory cytokines produced within the subarachnoid space may progressively impair and partially invert neurovascular coupling (NVC) in the brain. Because cerebral and retinal microvasculature are governed by comparable regulatory mechanisms and may be connected by perivascular pathways, retinal vascular changes are increasingly recognized as a potential surrogate for altered NVC in the brain. Here, we used non-invasive retinal vessel analysis (RVA) to assess microvascular function in aSAH patients at different times after the ictus.}, language = {en} } @article{AlbannaKotliarLuekeetal.2018, author = {Albanna, Walid and Kotliar, Konstantin and L{\"u}ke, Jan Niklas and Alpdogan, Serdar and Conzen, Catharina and Lindauer, Ute and Clusmann, Hans and Hescheler, J{\"u}rgen and Vilser, Walthard and Schneider, Toni and Schubert, Gerrit Alexander}, title = {Non-invasive evaluation of neurovascular coupling in the murine retina by dynamic retinal vessel analysis}, series = {Plos one}, volume = {13}, journal = {Plos one}, number = {10}, publisher = {PLOS}, address = {San Francisco}, doi = {10.1371/journal.pone.0204689}, pages = {e0204689}, year = {2018}, abstract = {Background Impairment of neurovascular coupling (NVC) was recently reported in the context of subarachnoid hemorrhage and may correlate with disease severity and outcome. However, previous techniques to evaluate NVC required invasive procedures. Retinal vessels may represent an alternative option for non-invasive assessment of NVC. Methods A prototype of an adapted retinal vessel analyzer was used to assess retinal vessel diameter in mice. Dynamic vessel analysis (DVA) included an application of monochromatic flicker light impulses in predefined frequencies for evaluating NVC. All retinae were harvested after DVA and electroretinograms were performed. Results A total of 104 retinal scans were conducted in 21 male mice (90 scans). Quantitative arterial recordings were feasible only in a minority of animals, showing an emphasized reaction to flicker light impulses (8 mice; 14 scans). A characteristic venous response to flicker light, however, could observed in the majority of animals. Repeated measurements resulted in a significant decrease of baseline venous diameter (7 mice; 7 scans, p < 0.05). Ex-vivo electroretinograms, performed after in-vivo DVA, demonstrated a significant reduction of transretinal signaling in animals with repeated DVA (n = 6, p < 0.001). Conclusions To the best of our knowledge, this is the first non-invasive study assessing murine retinal vessel response to flicker light with characteristic changes in NVC. The imaging system can be used for basic research and enables the investigation of retinal vessel dimension and function in control mice and genetically modified animals.}, language = {en} } @article{AlbannaLuekeSjapicetal.2017, author = {Albanna, Walid and Lueke, Jan Niklas and Sjapic, Volha and Kotliar, Konstantin and Hescheler, J{\"u}rgen and Clusmann, Hans and Sjapic, Sergej and Alpdogan, Serdan and Schneider, Toni and Schubert, Gerrit Alexander and Neumaier, Felix}, title = {Electroretinographic Assessment of Inner Retinal Signaling in the Isolated and Superfused Murine Retina}, series = {Current Eye Research}, journal = {Current Eye Research}, number = {Article in press}, publisher = {Taylor \& Francis}, address = {London}, issn = {1460-2202}, doi = {10.1080/02713683.2017.1339807}, pages = {1 -- 9}, year = {2017}, language = {en} } @article{AlbannaLuekeSchubertetal.2019, author = {Albanna, Walid and L{\"u}ke, Jan Niklas and Schubert, Gerrit Alexander and Dibu{\´e}-Adjei, Maxine and Kotliar, Konstantin and Hescheler, J{\"u}rgen and Clusmann, Hans and Steiger, Hans-Jakob and H{\"a}nggi, Daniel and Kamp, Marcel A. and Schneider, Toni and Neumaier, Felix}, title = {Modulation of Ca v 2.3 channels by unconjugated bilirubin (UCB) - Candidate mechanism for UCB-induced neuromodulation and neurotoxicity}, series = {Molecular and Cellular Neuroscience}, volume = {96}, journal = {Molecular and Cellular Neuroscience}, number = {4}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1044-7431}, doi = {10.1016/j.mcn.2019.03.003}, pages = {35 -- 46}, year = {2019}, language = {en} } @article{AlbrachtArampatzisBaltzopoulos2008, author = {Albracht, Kirsten and Arampatzis, A. and Baltzopoulos, V.}, title = {Assessment of muscle volume and physiological cross-sectional area of the human triceps surae muscle in vivo}, series = {Journal of Biomechanics}, volume = {41}, journal = {Journal of Biomechanics}, issn = {0021-9290}, doi = {10.1016/j.jbiomech.2008.04.020}, pages = {2211 -- 2218}, year = {2008}, language = {en} } @article{AlbrachtArampatzis2013, author = {Albracht, Kirsten and Arampatzis, Adamantios}, title = {Exercise-induced changes in triceps surae tendon stiffness and muscle strength affect running economy in humans}, series = {European Journal of Applied Physiology}, volume = {113}, journal = {European Journal of Applied Physiology}, number = {6}, publisher = {Springer}, address = {Berlin}, issn = {1439-6327}, doi = {10.1007/s00421-012-2585-4}, pages = {1605 -- 1615}, year = {2013}, language = {en} } @article{AlbrachtArampatzis2006, author = {Albracht, Kirsten and Arampatzis, Adamantios}, title = {Influence of the mechanical properties of the muscle-tendon unit on force generation in runners with different running economy}, series = {Biological Cybernetics}, volume = {95}, journal = {Biological Cybernetics}, number = {1}, issn = {1432-0770}, doi = {10.1007/s00422-006-0070-z}, pages = {87 -- 96}, year = {2006}, language = {en} } @article{AlebouyehSamamiPieperBreitbachetal.2014, author = {Alebouyeh Samami, Behzad and Pieper, Martin and Breitbach, Gerd and Hodapp, Josef}, title = {Heat production in the windings of the stators of electric machines under stationary condition}, series = {Heat and mass transfer}, volume = {50}, journal = {Heat and mass transfer}, publisher = {Springer}, address = {Heidelberg}, issn = {0947-7411 (Print) ; 1432-1181 (E-Journal)}, doi = {10.1007/s00231-014-1371-8}, pages = {1707 -- 1716}, year = {2014}, abstract = {In electric machines due to high currents and resistive losses (joule heating) heat is produced. To avoid damages by overheating the design of effective cooling systems is required. Therefore the knowledge of heat sources and heat transfer processes is necessary. The purpose of this paper is to illustrate a good and effective calculation method for the temperature analysis based on homogenization techniques. These methods have been applied for the stator windings in a slot of an electric machine consisting of copper wires and resin. The key quantity here is an effective thermal conductivity, which characterizes the heterogeneous wire resin-arrangement inside the stator slot. To illustrate the applicability of the method, the analysis of a simplified, homogenized model is compared with the detailed analysis of temperature behavior inside a slot of an electric machine according to the heat generation. We considered here only the stationary situation. The achieved numerical results are accurate and show that the applied homogenization technique works in practice. Finally the results of simulations for the two cases, the original model of the slot and the homogenized model chosen for the slot (unit cell), are compared to experimental results.}, language = {en} } @article{AletseeBaumann1991, author = {Aletsee, Ludwig and Baumann, Marcus}, title = {A laboratory incubator equipped with facilities to automatically simulate natural irradiance}, series = {Boletim do Instituto Oceanogr{\´a}fico / Universidade de S{\~a}o Paulo}, volume = {Vol. 39}, journal = {Boletim do Instituto Oceanogr{\´a}fico / Universidade de S{\~a}o Paulo}, number = {No. 2}, issn = {1982-436X; 0080-6331}, pages = {155 -- 159}, year = {1991}, language = {en} } @article{Alexopoulos2012, author = {Alexopoulos, Spiros}, title = {Biogas systems: basics, biogas multifunction, principle of fermentation and hybrid application with a solar tower for the treatment of waste animal manure}, series = {Journal of Engineering Science and Technology Review}, volume = {5}, journal = {Journal of Engineering Science and Technology Review}, number = {4}, issn = {1791-2377}, pages = {48 -- 55}, year = {2012}, abstract = {Two of the main environmental problems of today's society are the continuously increasing production of organic wastes as well as the increase of carbon dioxide in the atmosphere and the related green house effect. A way to solve these problems is the production of biogas. Biogas is a combustible gas consisting of methane, carbon dioxide and small amounts of other gases and trace elements. Production of biogas through anaerobic digestion of animal manure and slurries as well as of a wide range of digestible organic wastes and agricultural residues, converts these substrates into electricity and heat and offers a natural fertiliser for agriculture. The microbiological process of decomposition of organic matter, in the absence of oxygen takes place in reactors, called digesters. Biogas can be used as a fuel in a gas turbine or burner and can be used in a hybrid solar tower system offering a solution for waste treatment of agricultural and animal residues. A solar tower system consists of a heliostat field, which concentrates direct solar irradiation on an open volumetric central receiver. The receiver heats up ambient air to temperatures of around 700°C. The hot air's heat energy is transferred to a steam Rankine cycle in a heat recovery steam generator (HRSG). The steam drives a steam turbine, which in turn drives a generator for producing electricity. In order to increase the operational hours of a solar tower power plant, a heat storage system and/ or hybridization may be considered. The advantage of solar-fossil hybrid power plants, compared to solar-only systems, lies in low additional investment costs due to an adaptable solar share and reduced technical and economical risks. On sunny days the hybrid system operates in a solar-only mode with the central receiver and on cloudy days and at night with the gas turbine only. As an alternative to methane gas, environmentally neutral biogas can be used for operating the gas turbine. Hence, the hybrid system is operated to 100\% from renewable energy sources}, language = {en} } @article{Alexopoulos2015, author = {Alexopoulos, Spiros}, title = {Simulation model for the transient process behaviour of solar aluminium recycling in a rotary kiln}, series = {Applied Thermal Engineering}, volume = {78}, journal = {Applied Thermal Engineering}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1359-4311}, doi = {10.1016/j.applthermaleng.2015.01.007}, pages = {387 -- 396}, year = {2015}, language = {en} } @article{AlexopoulosBreitbachHoffschmidtetal.2008, author = {Alexopoulos, Spiros and Breitbach, Gerd and Hoffschmidt, Bernhard and Stobbe, P.}, title = {Computational fluid flow of porous resic ceramic filtering modules and optimization of the channel edge form geometry}, series = {Proceedings : April 14 - 18, 2008, Leipzig, Germany / hosted by VDI, Society for Chemical and Process Engineering . Vol 2}, journal = {Proceedings : April 14 - 18, 2008, Leipzig, Germany / hosted by VDI, Society for Chemical and Process Engineering . Vol 2}, publisher = {Filtech Exhibitions}, address = {Meerbusch}, pages = {300 -- 304}, year = {2008}, language = {en} } @article{AlexopoulosBreitbachHoffschmidtetal.2008, author = {Alexopoulos, Spiros and Breitbach, Gerd and Hoffschmidt, Bernhard and Stobbe, P.}, title = {Optimization of the geometry of porous SiC ceramic filtering modules using numerical methods}, series = {Developments in porous, biological and geopolymer ceramics : a collection of papers presented at the 31st International Conference on Advanced Ceramics and Composites, January 21 - 26, 2007, Daytona Beach, Florida ; [papers presented at the Symposium on Porous Ceramics: Novel Developments and Applications] / ed.: Manuel Brito ... Vol. ed.: Jonathan Salem ... The American Ceramics Society}, journal = {Developments in porous, biological and geopolymer ceramics : a collection of papers presented at the 31st International Conference on Advanced Ceramics and Composites, January 21 - 26, 2007, Daytona Beach, Florida ; [papers presented at the Symposium on Porous Ceramics: Novel Developments and Applications] / ed.: Manuel Brito ... Vol. ed.: Jonathan Salem ... The American Ceramics Society}, publisher = {Wiley}, address = {Hoboken, NJ}, isbn = {9780470196403}, pages = {95 -- 104}, year = {2008}, language = {en} } @article{AlexopoulosHoffschmidt2010, author = {Alexopoulos, Spiros and Hoffschmidt, Bernhard}, title = {Solar tower power plant in Germany and future perspectives of the development of the technology in Greece and Cyprus}, series = {Renewable Energy . 35 (2010), H. 7}, journal = {Renewable Energy . 35 (2010), H. 7}, isbn = {0960-1481}, pages = {1352 -- 1356}, year = {2010}, language = {en} } @article{AlexopoulosHoffschmidt2017, author = {Alexopoulos, Spiros and Hoffschmidt, Bernhard}, title = {Advances in solar tower technology}, series = {Wiley interdisciplinary reviews : Energy and Environment : WIREs}, volume = {6}, journal = {Wiley interdisciplinary reviews : Energy and Environment : WIREs}, number = {1}, publisher = {Wiley}, address = {Weinheim}, issn = {2041-840X}, doi = {10.1002/wene.217}, pages = {1 -- 19}, year = {2017}, language = {en} } @article{AlexyukBogoyavlenskiyAlexyuketal.2021, author = {Alexyuk, Madina and Bogoyavlenskiy, Andrey and Alexyuk, Pavel and Moldakhanov, Yergali and Berezin, Vladimir and Digel, Ilya}, title = {Epipelagic microbiome of the Small Aral Sea: Metagenomic structure and ecological diversity}, series = {MicrobiologyOpen}, volume = {10}, journal = {MicrobiologyOpen}, number = {1}, publisher = {Wiley}, address = {Weinheim}, issn = {2045-8827}, doi = {10.1002/mbo3.1142}, pages = {1 -- 10}, year = {2021}, abstract = {Microbial diversity studies regarding the aquatic communities that experienced or are experiencing environmental problems are essential for the comprehension of the remediation dynamics. In this pilot study, we present data on the phylogenetic and ecological structure of microorganisms from epipelagic water samples collected in the Small Aral Sea (SAS). The raw data were generated by massive parallel sequencing using the shotgun approach. As expected, most of the identified DNA sequences belonged to Terrabacteria and Actinobacteria (40\% and 37\% of the total reads, respectively). The occurrence of Deinococcus-Thermus, Armatimonadetes, Chloroflexi in the epipelagic SAS waters was less anticipated. Surprising was also the detection of sequences, which are characteristic for strict anaerobes—Ignavibacteria, hydrogen-oxidizing bacteria, and archaeal methanogenic species. We suppose that the observed very broad range of phylogenetic and ecological features displayed by the SAS reads demonstrates a more intensive mixing of water masses originating from diverse ecological niches of the Aral-Syr Darya River basin than presumed before.}, language = {en} } @article{AlhwarinFerreinScholl2014, author = {Alhwarin, Faraj and Ferrein, Alexander and Scholl, Ingrid}, title = {IR stereo kinect: improving depth images by combining structured light with IR stereo}, pages = {1 -- 9}, year = {2014}, language = {en} } @article{AllefeldBialonski2007, author = {Allefeld, Carsten and Bialonski, Stephan}, title = {Detecting synchronization clusters in multivariate time series via coarse-graining of Markov chains}, series = {Physical Review E}, volume = {76}, journal = {Physical Review E}, number = {6}, issn = {2470-0053}, doi = {10.1103/PhysRevE.76.066207}, pages = {066207}, year = {2007}, language = {en} } @article{AlmajhdiSengerAmeretal.2014, author = {Almajhdi, Fahad N. and Senger, Tilo and Amer, Haitham M. and Gissmann, Lutz and {\"O}hlschl{\"a}ger, Peter}, title = {Design of a highly effective therapeutic HPV16 E6/E7-specific DNA vaccine: optimization by different ways of sequence rearrangements (Shuffling)}, series = {PLOS one}, volume = {11}, journal = {PLOS one}, number = {9}, publisher = {PLOS}, address = {San Francisco}, issn = {1932-6203}, doi = {10.1371/journal.pone.0113461}, pages = {e113461}, year = {2014}, abstract = {Persistent infection with the high-risk Human Papillomavirus type 16 (HPV 16) is the causative event for the development of cervical cancer and other malignant tumors of the anogenital tract and of the head and neck. Despite many attempts to develop therapeutic vaccines no candidate has entered late clinical trials. An interesting approach is a DNA based vaccine encompassing the nucleotide sequence of the E6 and E7 viral oncoproteins. Because both proteins are consistently expressed in HPV infected cells they represent excellent targets for immune therapy. Here we report the development of 8 DNA vaccine candidates consisting of differently rearranged HPV-16 E6 and E7 sequences within one molecule providing all naturally occurring epitopes but supposedly lacking transforming activity. The HPV sequences were fused to the J-domain and the SV40 enhancer in order to increase immune responses. We demonstrate that one out of the 8 vaccine candidates induces very strong cellular E6- and E7- specific cellular immune responses in mice and, as shown in regression experiments, efficiently controls growth of HPV 16 positive syngeneic tumors. This data demonstrates the potential of this vaccine candidate to control persistent HPV 16 infection that may lead to malignant disease. It also suggests that different sequence rearrangements influence the immunogenecity by an as yet unknown mechanism.}, language = {en} } @article{AlnemerKotliarNeuhausetal.2023, author = {Alnemer, Momin Sami Mohammad and Kotliar, Konstantin and Neuhaus, Valentin and Pape, Hans-Christoph and Ciritsis, Bernhard D.}, title = {Cost-effectiveness analysis of surgical proximal femur fracture prevention in elderly: a Markov cohort simulation model}, series = {Cost Effectiveness and Resource Allocation}, journal = {Cost Effectiveness and Resource Allocation}, number = {21, Article number: 77}, publisher = {Springer Nature}, issn = {1478-7547}, doi = {10.1186/s12962-023-00482-4}, pages = {12 Seiten}, year = {2023}, abstract = {Background Hip fractures are a common and costly health problem, resulting in significant morbidity and mortality, as well as high costs for healthcare systems, especially for the elderly. Implementing surgical preventive strategies has the potential to improve the quality of life and reduce the burden on healthcare resources, particularly in the long term. However, there are currently limited guidelines for standardizing hip fracture prophylaxis practices. Methods This study used a cost-effectiveness analysis with a finite-state Markov model and cohort simulation to evaluate the primary and secondary surgical prevention of hip fractures in the elderly. Patients aged 60 to 90 years were simulated in two different models (A and B) to assess prevention at different levels. Model A assumed prophylaxis was performed during the fracture operation on the contralateral side, while Model B included individuals with high fracture risk factors. Costs were obtained from the Centers for Medicare \& Medicaid Services, and transition probabilities and health state utilities were derived from available literature. The baseline assumption was a 10\% reduction in fracture risk after prophylaxis. A sensitivity analysis was also conducted to assess the reliability and variability of the results. Results With a 10\% fracture risk reduction, model A costs between \$8,850 and \$46,940 per quality-adjusted life-year (\$/QALY). Additionally, it proved most cost-effective in the age range between 61 and 81 years. The sensitivity analysis established that a reduction of ≥ 2.8\% is needed for prophylaxis to be definitely cost-effective. The cost-effectiveness at the secondary prevention level was most sensitive to the cost of the contralateral side's prophylaxis, the patient's age, and fracture treatment cost. For high-risk patients with no fracture history, the cost-effectiveness of a preventive strategy depends on their risk profile. In the baseline analysis, the incremental cost-effectiveness ratio at the primary prevention level varied between \$11,000/QALY and \$74,000/QALY, which is below the defined willingness to pay threshold. Conclusion Due to the high cost of hip fracture treatment and its increased morbidity, surgical prophylaxis strategies have demonstrated that they can significantly relieve the healthcare system. Various key assumptions facilitated the modeling, allowing for adequate room for uncertainty. Further research is needed to evaluate health-state-associated risks.}, language = {en} } @article{AltherrBroetzDietrichetal.2018, author = {Altherr, Lena and Br{\"o}tz, Nicolas and Dietrich, Ingo and Gally, Tristan and Geßner, Felix and Kloberdanz, Hermann and Leise, Philipp and Pelz, Peter Franz and Schlemmer, Pia and Schmitt, Andreas}, title = {Resilience in mechanical engineering - a concept for controlling uncertainty during design, production and usage phase of load-carrying structures}, series = {Applied Mechanics and Materials}, volume = {885}, journal = {Applied Mechanics and Materials}, publisher = {Trans Tech Publications}, address = {B{\"a}ch}, isbn = {1662-7482}, doi = {10.4028/www.scientific.net/AMM.885.187}, pages = {187 -- 198}, year = {2018}, abstract = {Resilience as a concept has found its way into different disciplines to describe the ability of an individual or system to withstand and adapt to changes in its environment. In this paper, we provide an overview of the concept in different communities and extend it to the area of mechanical engineering. Furthermore, we present metrics to measure resilience in technical systems and illustrate them by applying them to load-carrying structures. By giving application examples from the Collaborative Research Centre (CRC) 805, we show how the concept of resilience can be used to control uncertainty during different stages of product life.}, language = {en} } @article{AltherrEdererLorenzetal.2014, author = {Altherr, Lena and Ederer, Thorsten and Lorenz, Ulf and Pelz, Peter F. and P{\"o}ttgen, Philipp}, title = {Experimental validation of an enhanced system synthesis approach}, series = {Operations Research Proceedings 2014}, journal = {Operations Research Proceedings 2014}, editor = {L{\"u}bbecke, Marco and Koster, Arie and Letmathe, Peter and Madlener, Reihard and Peis, Britta and Walther, Grit}, publisher = {Springer}, address = {Basel}, isbn = {978-3-319-28695-2}, doi = {10.1007/978-3-319-28697-6_1}, pages = {6}, year = {2014}, abstract = {Planning the layout and operation of a technical system is a common task for an engineer. Typically, the workflow is divided into consecutive stages: First, the engineer designs the layout of the system, with the help of his experience or of heuristic methods. Secondly, he finds a control strategy which is often optimized by simulation. This usually results in a good operating of an unquestioned sys- tem topology. In contrast, we apply Operations Research (OR) methods to find a cost-optimal solution for both stages simultaneously via mixed integer program- ming (MILP). Technical Operations Research (TOR) allows one to find a provable global optimal solution within the model formulation. However, the modeling error due to the abstraction of physical reality remains unknown. We address this ubiq- uitous problem of OR methods by comparing our computational results with mea- surements in a test rig. For a practical test case we compute a topology and control strategy via MILP and verify that the objectives are met up to a deviation of 8.7\%.}, language = {en} } @article{AltherrEdererPoettgenetal.2015, author = {Altherr, Lena and Ederer, Thorsten and P{\"o}ttgen, Philipp and Lorenz, Ulf and Pelz, Peter F.}, title = {Multicriterial optimization of technical systems considering multiple load and availability scenarios}, series = {Applied Mechanics and Materials}, volume = {807}, journal = {Applied Mechanics and Materials}, editor = {Pelz, Peter F. and Groche, Peter}, isbn = {1660-9336}, doi = {10.4028/www.scientific.net/AMM.807.247}, pages = {247 -- 256}, year = {2015}, abstract = {Cheap does not imply cost-effective -- this is rule number one of zeitgeisty system design. The initial investment accounts only for a small portion of the lifecycle costs of a technical system. In fluid systems, about ninety percent of the total costs are caused by other factors like power consumption and maintenance. With modern optimization methods, it is already possible to plan an optimal technical system considering multiple objectives. In this paper, we focus on an often neglected contribution to the lifecycle costs: downtime costs due to spontaneous failures. Consequently, availability becomes an issue.}, language = {en} } @article{AltherrJoggerstLeiseetal.2018, author = {Altherr, Lena and Joggerst, Laura and Leise, Philipp and Pfetsch, Marc E. and Schmitt, Andreas and Wendt, Janine}, title = {On obligations in the development process of resilient systems with algorithmic design methods}, series = {Applied Mechanics and Materials}, volume = {885}, journal = {Applied Mechanics and Materials}, number = {885}, publisher = {Trans Tech Publications}, address = {B{\"a}ch}, isbn = {1662-7482}, doi = {10.4028/www.scientific.net/AMM.885.240}, pages = {240 -- 252}, year = {2018}, abstract = {Advanced computational methods are needed both for the design of large systems and to compute high accuracy solutions. Such methods are efficient in computation, but the validation of results is very complex, and highly skilled auditors are needed to verify them. We investigate legal questions concerning obligations in the development phase, especially for technical systems developed using advanced methods. In particular, we consider methods of resilient and robust optimization. With these techniques, high performance solutions can be found, despite a high variety of input parameters. However, given the novelty of these methods, it is uncertain whether legal obligations are being met. The aim of this paper is to discuss if and how the choice of a specific computational method affects the developer's product liability. The review of legal obligations in this paper is based on German law and focuses on the requirements that must be met during the design and development process.}, language = {en} } @article{AltherrLeisePfetschetal.2018, author = {Altherr, Lena and Leise, Philipp and Pfetsch, Marc E. and Schmitt, Andreas}, title = {Algorithmic design and resilience assessment of energy efficient high-rise water supply systems}, series = {Applied Mechanics and Materials}, volume = {885}, journal = {Applied Mechanics and Materials}, publisher = {Trans Tech Publications}, address = {B{\"a}ch}, issn = {1662-7482}, doi = {10.4028/www.scientific.net/AMM.885.211}, pages = {211 -- 223}, year = {2018}, abstract = {High-rise water supply systems provide water flow and suitable pressure in all levels of tall buildings. To design such state-of-the-art systems, the consideration of energy efficiency and the anticipation of component failures are mandatory. In this paper, we use Mixed-Integer Nonlinear Programming to compute an optimal placement of pipes and pumps, as well as an optimal control strategy.Moreover, we consider the resilience of the system to pump failures. A resilient system is able to fulfill a predefined minimum functionality even though components fail or are restricted in their normal usage. We present models to measure and optimize the resilience. To demonstrate our approach, we design and analyze an optimal resilient decentralized water supply system inspired by a real-life hotel building.}, language = {en} } @article{AminTemizArtmannArtmannetal.2009, author = {Amin, Rashid and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard and Lazarovici, Philip and Lelkes, Peter I.}, title = {Permeability of an In Vitro Model of Blood Brain Barrier (BBB)}, series = {13th International Conference on Biomedical Engineering / Lim, Chwee Teck [Ed.]}, journal = {13th International Conference on Biomedical Engineering / Lim, Chwee Teck [Ed.]}, isbn = {978-3-540-92841-6}, pages = {81 -- 84}, year = {2009}, language = {en} } @article{AndingTabazaStaatetal.2013, author = {Anding, Ralf and Tabaza, Ruth and Staat, Manfred and Trenz, Eva and Lohmann, Philipp and Klinge, Uwe and Kirschner-Hermanns, Ruth}, title = {Introducing a method of in vitro testing of different anchoring systems used for female incontinence and prolapse surgery}, series = {BioMed research international}, volume = {Vol. 2013}, journal = {BioMed research international}, issn = {1110-7251 (E-Journal); 2314-6141 (E-Journal); 1110-7243 (Print); 2314-6133 (Print)}, pages = {Article ID 401417}, year = {2013}, language = {en} } @article{AngermannGuenthnerHanssenetal.2022, author = {Angermann, Susanne and G{\"u}nthner, Roman and Hanssen, Henner and Lorenz, Georg and Braunisch, Matthias C. and Steubl, Dominik and Matschkal, Julia and Kemmner, Stephan and Hausinger, Renate and Block, Zenonas and Haller, Bernhard and Heemann, Uwe and Kotliar, Konstantin and Grimmer, Timo and Schmaderer, Christoph}, title = {Cognitive impairment and microvascular function in end-stage renal disease}, series = {International Journal of Methods in Psychiatric Research (MPR)}, volume = {31}, journal = {International Journal of Methods in Psychiatric Research (MPR)}, number = {2}, publisher = {Wiley}, issn = {1049-8931 (Print)}, doi = {10.1002/mpr.1909}, pages = {1 -- 10}, year = {2022}, abstract = {Objective Hemodialysis patients show an approximately threefold higher prevalence of cognitive impairment compared to the age-matched general population. Impaired microcirculatory function is one of the assumed causes. Dynamic retinal vessel analysis is a quantitative method for measuring neurovascular coupling and microvascular endothelial function. We hypothesize that cognitive impairment is associated with altered microcirculation of retinal vessels. Methods 152 chronic hemodialysis patients underwent cognitive testing using the Montreal Cognitive Assessment. Retinal microcirculation was assessed by Dynamic Retinal Vessel Analysis, which carries out an examination recording retinal vessels' reaction to a flicker light stimulus under standardized conditions. Results In unadjusted as well as in adjusted linear regression analyses a significant association between the visuospatial executive function domain score of the Montreal Cognitive Assessment and the maximum arteriolar dilation as response of retinal arterioles to the flicker light stimulation was obtained. Conclusion This is the first study determining retinal microvascular function as surrogate for cerebral microvascular function and cognition in hemodialysis patients. The relationship between impairment in executive function and reduced arteriolar reaction to flicker light stimulation supports the involvement of cerebral small vessel disease as contributing factor for the development of cognitive impairment in this patient population and might be a target for noninvasive disease monitoring and therapeutic intervention.}, language = {en} } @article{AnikFrohberg1984, author = {Anik, Sabri and Frohberg, Martin G.}, title = {Thermodynamics and solubility of oxygen in liquid copper-lead alloys at 1200°C from E.M.F. measurements}, series = {Berichte der Bunsengesellschaft f{\"u}r physikalische Chemie}, volume = {88}, journal = {Berichte der Bunsengesellschaft f{\"u}r physikalische Chemie}, number = {8}, issn = {0940-483X}, pages = {707 -- 710}, year = {1984}, language = {en} } @article{AnikFrohberg1987, author = {Anik, Sabri and Frohberg, Martin G.}, title = {Thermodynamics and solubility of oxygen in liquid bismuth-lead and bismuth-antimony alloys}, series = {Berichte der Bunsengesellschaft f{\"u}r physikalische Chemie}, volume = {91}, journal = {Berichte der Bunsengesellschaft f{\"u}r physikalische Chemie}, number = {7}, issn = {0940-483X}, pages = {790 -- 794}, year = {1987}, language = {en} } @article{AnikFrohberg1984, author = {Anik, Sabri and Frohberg, Martin G.}, title = {Investigations of the thermodynamics of oxygen and the determination of the miscibility gap in the system copper-oxygen-lead at 12000C}, series = {Zeitschrift f{\"u}r Metallkunde}, volume = {75}, journal = {Zeitschrift f{\"u}r Metallkunde}, number = {8}, issn = {0044-3093}, pages = {586 -- 589}, year = {1984}, language = {en} } @article{AnikFrohberg1983, author = {Anik, Sabri and Frohberg, Martin G.}, title = {Investigation of the thermodynamics of oxygen and the determination of phase boundaries in the system copper-oxygen-bismuth at 12000C}, series = {Zeitschrift f{\"u}r Metallkunde}, volume = {74}, journal = {Zeitschrift f{\"u}r Metallkunde}, number = {8}, issn = {0044-3093}, pages = {530 -- 534}, year = {1983}, language = {en} } @article{AnikFrohberg1988, author = {Anik, Sabri and Frohberg, Martin G.}, title = {Thermodynamics of oxygen in the copper-antimony system at 1473K}, series = {Erzmetall : Rohstoffgewinnung, Verarbeitung, Recycling, Umwelttechnik}, volume = {41}, journal = {Erzmetall : Rohstoffgewinnung, Verarbeitung, Recycling, Umwelttechnik}, number = {10}, issn = {0044-2658}, pages = {498 -- 501}, year = {1988}, language = {en} } @article{AnikFrohbergKapoor1983, author = {Anik, Sabri and Frohberg, Martin G. and Kapoor, Madan Lal}, title = {Experiments and theoretical considerations on the solution of oxygen in binary metal alloys}, series = {Berichte der Bunsengesellschaft f{\"u}r physikalische Chemie}, volume = {87}, journal = {Berichte der Bunsengesellschaft f{\"u}r physikalische Chemie}, number = {12}, issn = {0005-9021}, pages = {1201 -- 1204}, year = {1983}, language = {en} } @article{AnikFrohbergKapoor1983, author = {Anik, Sabri and Frohberg, Martin G. and Kapoor, Madan Lal}, title = {Prediction of thermodynamic properties of oxygen in binary metallic solvents}, series = {Zeitschrift f{\"u}r Metallkunde}, volume = {74}, journal = {Zeitschrift f{\"u}r Metallkunde}, number = {6}, issn = {0044-3093}, pages = {372 -- 375}, year = {1983}, language = {en} } @article{AnikKapoorFrohberg1983, author = {Anik, Sabri and Kapoor, Madan Lal and Frohberg, Martin G.}, title = {Thermodynamic behaviour of oxygen in molten substitutional alloy solvents}, series = {Zeitschrift f{\"u}r Metallkunde}, volume = {74}, journal = {Zeitschrift f{\"u}r Metallkunde}, number = {1}, issn = {0044-3093}, pages = {53 -- 58}, year = {1983}, language = {en} } @article{ArampatzisKaramanidisAlbracht2007, author = {Arampatzis, Adamantios and Karamanidis, Kiros and Albracht, Kirsten}, title = {Adaptational responses of the human Achilles tendon by modulation of the applied cyclic strain magnitude}, series = {Journal of Experimental Biology}, volume = {210}, journal = {Journal of Experimental Biology}, number = {15}, issn = {0022-0949}, doi = {10.1242/jeb.003814}, pages = {2743 -- 2753}, year = {2007}, language = {en} } @article{ArampatzisKaramanidisMademlietal.2009, author = {Arampatzis, Adamantios and Karamanidis, Kiros and Mademli, Lida and Albracht, Kirsten}, title = {Plasticity of the human tendon to short and long-term mechanical loading}, series = {Exercise and Sport Sciences Reviews}, volume = {37}, journal = {Exercise and Sport Sciences Reviews}, number = {2}, issn = {1538-3008}, doi = {10.1097/JES.0b013e31819c2e1d}, pages = {66 -- 72}, year = {2009}, language = {en} } @article{ArampatzisPeperBierbaumetal.2010, author = {Arampatzis, Adamantios and Peper, Andreas and Bierbaum, Stefanie and Albracht, Kirsten}, title = {Plasticity of human Achilles tendon mechanical and morphological properties in response to cyclic strain}, series = {Journal of Biomechanics}, volume = {43}, journal = {Journal of Biomechanics}, number = {16}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0021-9290}, doi = {10.1016/j.jbiomech.2010.08.014}, pages = {3073 -- 3079}, year = {2010}, abstract = {The purpose of the current study in combination with our previous published data (Arampatzis et al., 2007) was to examine the effects of a controlled modulation of strain magnitude and strain frequency applied to the Achilles tendon on the plasticity of tendon mechanical and morphological properties. Eleven male adults (23.9±2.2 yr) participated in the study. The participants exercised one leg at low magnitude tendon strain (2.97±0.47\%), and the other leg at high tendon strain magnitude (4.72±1.08\%) of similar frequency (0.5 Hz, 1 s loading, 1 s relaxation) and exercise volume (integral of the plantar flexion moment over time) for 14 weeks, 4 days per week, 5 sets per session. The exercise volume was similar to the intervention of our earlier study (0.17 Hz frequency; 3 s loading, 3 s relaxation) allowing a direct comparison of the results. Before and after the intervention ankle joint moment has been measured by a dynamometer, tendon-aponeurosis elongation by ultrasound and cross-sectional area of the Achilles tendon by magnet resonance images (MRI). We found a decrease in strain at a given tendon force, an increase in tendon-aponeurosis stiffness and tendon elastic modulus of the Achilles tendon only in the leg exercised at high strain magnitude. The cross-sectional area (CSA) of the Achilles tendon did not show any statistically significant (P>0.05) differences to the pre-exercise values in both legs. The results indicate a superior improvement in tendon properties (stiffness, elastic modulus and CSA) at the low frequency (0.17 Hz) compared to the high strain frequency (0.5 Hz) protocol. These findings provide evidence that the strain magnitude applied to the Achilles tendon should exceed the value, which occurs during habitual activities to trigger adaptational effects and that higher tendon strain duration per contraction leads to superior tendon adaptational responses.}, language = {en} } @article{AridaAlhaddadSchoening2011, author = {Arida, Hassan A. and Al-haddad, Ameera and Sch{\"o}ning, Michael Josef}, title = {New Solid-State Organic Membrane Based Lead-Selective Micro-Electrode}, series = {International Journal of Electrochemical Science. 6 (2011), H. 9}, journal = {International Journal of Electrochemical Science. 6 (2011), H. 9}, isbn = {1452-3981}, pages = {3858 -- 3867}, year = {2011}, language = {en} } @article{AridaMohsenSchoening2009, author = {Arida, Hassan and Mohsen, Q. and Sch{\"o}ning, Michael Josef}, title = {Microfabrication, characterization and analytical application of a new thin-film silver microsensor}, series = {Electrochimica Acta. 54 (2009), H. 13}, journal = {Electrochimica Acta. 54 (2009), H. 13}, isbn = {0013-4686}, pages = {3543 -- 3547}, year = {2009}, language = {en} } @article{AridaTurekRolkaetal.2009, author = {Arida, Hassan and Turek, Monika and Rolka, David and Sch{\"o}ning, Michael Josef}, title = {A Novel Thin-Film Copper Array Based on an Organic/Inorganic Sensor Hybrid: Microfabrication, Potentiometric Characterization, and Flow-Injection Analysis Application}, series = {Electroanalysis. 21 (2009), H. 10}, journal = {Electroanalysis. 21 (2009), H. 10}, publisher = {Wiley}, address = {Weinheim}, isbn = {1040-0397}, pages = {1145 -- 1151}, year = {2009}, language = {en} } @article{ArinkinDigelPorstetal.2014, author = {Arinkin, Vladimir and Digel, Ilya and Porst, Dariusz and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard}, title = {Phenotyping date palm varieties via leaflet cross-sectional imaging and artificial neural network application}, series = {BMC bioinformatics}, volume = {15}, journal = {BMC bioinformatics}, number = {55}, issn = {1471-2105}, doi = {10.1186/1471-2105-15-55}, pages = {1 -- 8}, year = {2014}, abstract = {Background True date palms (Phoenix dactylifera L.) are impressive trees and have served as an indispensable source of food for mankind in tropical and subtropical countries for centuries. The aim of this study is to differentiate date palm tree varieties by analysing leaflet cross sections with technical/optical methods and artificial neural networks (ANN). Results Fluorescence microscopy images of leaflet cross sections have been taken from a set of five date palm tree cultivars (Hewlat al Jouf, Khlas, Nabot Soltan, Shishi, Um Raheem). After features extraction from images, the obtained data have been fed in a multilayer perceptron ANN with backpropagation learning algorithm. Conclusions Overall, an accurate result in prediction and differentiation of date palm tree cultivars was achieved with average prediction in tenfold cross-validation is 89.1\% and reached 100\% in one of the best ANN.}, language = {en} } @article{ArpshofenPoolSommeretal.1983, author = {Arpshofen, Ingo and Pool, M. J. and Sommer, Ferdinand and Gerling, Ulrich and Predel, Bruno and Schultheiss, Emil}, title = {Determination of the integral mixing enthalpies in the Cu-Pd-Si liquid ternary alloy system at 1600 K}, series = {Zeitschrift f{\"u}r Metallkunde : international journal of materials research and advanced techniques. Bd. 74, H. 1}, journal = {Zeitschrift f{\"u}r Metallkunde : international journal of materials research and advanced techniques. Bd. 74, H. 1}, issn = {0044-3093 ; 0179-4841}, pages = {25 -- 32}, year = {1983}, language = {en} } @article{ArreolaKeusgenSchoening2017, author = {Arreola, Julio and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Effect of O2 plasma on properties of electrolyte-insulator-semiconductor structures}, series = {physica status solidi a : applications and materials sciences}, volume = {214}, journal = {physica status solidi a : applications and materials sciences}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.201700025}, pages = {Artikel 1700025}, year = {2017}, abstract = {Prior to immobilization of biomolecules or cells onto biosensor surfaces, the surface must be physically or chemically activated for further functionalization. Organosilanes are a versatile option as they facilitate the immobilization through their terminal groups and also display self-assembly. Incorporating hydroxyl groups is one of the important methods for primary immobilization. This can be done, for example, with oxygen plasma treatment. However, this treatment can affect the performance of the biosensors and this effect is not quite well understood for surface functionalization. In this work, the effect of O2 plasma treatment on EIS sensors was investigated by means of electrochemical characterizations: capacitance-voltage (C-V) and constant capacitance (ConCap) measurements. After O2 plasma treatment, the potential of the EIS sensor dramatically shifts to a more negative value. This was successfully reset by using an annealing process.}, language = {en} } @article{ArreolaKeusgenSchoening2019, author = {Arreola, Julio and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Toward an immobilization method for spore-based biosensors in oxidative environment}, series = {Electrochimica Acta}, volume = {302}, journal = {Electrochimica Acta}, publisher = {Elsevier}, address = {Amsterdam}, doi = {10.1016/j.electacta.2019.01.148}, pages = {394 -- 401}, year = {2019}, language = {en} } @article{ArreolaKeusgenWagneretal.2019, author = {Arreola, Julio and Keusgen, Michael and Wagner, Torsten and Sch{\"o}ning, Michael Josef}, title = {Combined calorimetric gas- and spore-based biosensor array for online monitoring and sterility assurance of gaseous hydrogen peroxide in aseptic filling machines}, series = {Biosensors and Bioelectronics}, volume = {143}, journal = {Biosensors and Bioelectronics}, number = {111628}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0956-5663}, doi = {10.1016/j.bios.2019.111628}, year = {2019}, language = {en} } @article{ArreolaMaetzkowDuranetal.2016, author = {Arreola, Julio and M{\"a}tzkow, Malte and Dur{\´a}n, Marlena Palomar and Greeff, Anton and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Optimization of the immobilization of bacterial spores on glass substrates with organosilanes}, series = {Physica status solidi (A) : Applications and materials science}, volume = {213}, journal = {Physica status solidi (A) : Applications and materials science}, number = {6}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.201532914}, pages = {1463 -- 1470}, year = {2016}, abstract = {Spores can be immobilized on biosensors to function as sensitive recognition elements. However, the immobilization can affect the sensitivity and reproducibility of the sensor signal. In this work, three different immobilization strategies with organosilanes were optimized and characterized to immobilize Bacillus atrophaeus spores on glass substrates. Five different silanization parameters were investigated: nature of the solvent, concentration of the silane, silanization time, curing process, and silanization temperature. The resulting silane layers were resistant to a buffer solution (e.g., Ringer solution) with a polysorbate (e.g., Tween®80) and sonication.}, language = {en} } @article{ArreolaOberlaenderMaetzkowetal.2017, author = {Arreola, Julio and Oberl{\"a}nder, Jan and M{\"a}tzkow, M. and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Surface functionalization for spore-based biosensors with organosilanes}, series = {Electrochimica Acta}, volume = {241}, journal = {Electrochimica Acta}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0013-4686}, doi = {10.1016/j.electacta.2017.04.157}, pages = {237 -- 243}, year = {2017}, abstract = {In the present work, surface functionalization of different sensor materials was studied. Organosilanes are well known to serve as coupling agent for biomolecules or cells on inorganic materials. 3-aminopropyltriethoxysilane (APTES) was used to attach microbiological spores time to an interdigitated sensor surface. The functionality and physical properties of APTES were studied on isolated sensor materials, namely silicon dioxide (SiO2) and platinum (Pt) as well as the combined material on sensor level. A predominant immobilization of spores could be demonstrated on SiO2 surfaces. Additionally, the impedance signal of APTES-functionalized biosensor chips has been investigated.}, language = {en} } @article{Artmann1986, author = {Artmann, Gerhard}, title = {A microscopic photometric method for measuring erythrocyte deformability. Artmann, Gerhard Michael}, series = {Clinical Hemorheology. 6 (1986)}, journal = {Clinical Hemorheology. 6 (1986)}, isbn = {0271-5198}, pages = {617 -- 627}, year = {1986}, language = {en} } @article{Artmann1996, author = {Artmann, Gerhard}, title = {2nd International Conference on Medical Biorheology (ICMB). Shanghai, China, September 13-15, 1995. Shi, Young de, Artmann, Gerhard Michael, Meiselman, Herbert J.}, series = {Biorheology. 33 (1996), H. 6}, journal = {Biorheology. 33 (1996), H. 6}, isbn = {0006-355x}, pages = {505 -- 507}, year = {1996}, language = {en} } @article{Artmann1995, author = {Artmann, Gerhard}, title = {Microscopic photometric quantification of stiffness and relaxation time of red blood cells in a flow chamber. Artmann, Gerhard Michael}, series = {Biorheology. 32 (1995), H. 5}, journal = {Biorheology. 32 (1995), H. 5}, isbn = {0006-355x}, pages = {553 -- 570}, year = {1995}, language = {en} } @article{Artmann2000, author = {Artmann, Gerhard}, title = {Cellular engineering - a challenge for engineers? / Artmann, G. M.}, series = {Biomedizinische Technik = Biomedical Engineering. 45 (2000), H. s1}, journal = {Biomedizinische Technik = Biomedical Engineering. 45 (2000), H. s1}, isbn = {1862-278X}, pages = {449}, year = {2000}, language = {en} } @article{ArtmannBurnsCanavesetal.2004, author = {Artmann, Gerhard and Burns, Laura and Canaves, Jaume M. and Temiz Artmann, Ayseg{\"u}l}, title = {Circular dichroism spectra of human hemoglobin reveal a reversible structural transition at body temperature}, series = {European Biophysics Journal. 33 (2004), H. 6}, journal = {European Biophysics Journal. 33 (2004), H. 6}, isbn = {1432-1017}, pages = {490 -- 496}, year = {2004}, language = {en} } @article{ArtmannBaeumlerVoigtetal.2000, author = {Artmann, Gerhard and B{\"a}umler, H. and Voigt, A. and Mitl{\"o}hner, R. [u.a.]}, title = {Plastic behaviour of polyelectrolyte microcapsules derived from colloid templates. B{\"a}umler, H., Artmann, Gerhard Michael; Voigt, A., Mitl{\"o}hner, R., Neu, B., Kiesewetter, H.}, series = {Journal of Microencapsulation. 17 (2000), H. 5}, journal = {Journal of Microencapsulation. 17 (2000), H. 5}, isbn = {1464-5246}, pages = {651 -- 655}, year = {2000}, language = {en} } @article{ArtmannDigelLinderetal.2008, author = {Artmann, Gerhard and Digel, Ilya and Linder, Peter and Porst, Dariusz}, title = {Mechanism of haemoglobin sensing body temperature}, series = {Tissue Engineering Part A. 14 (2008), H. 5}, journal = {Tissue Engineering Part A. 14 (2008), H. 5}, isbn = {1937-3341}, pages = {754 -- 754}, year = {2008}, language = {en} } @article{ArtmannDigelZerlinetal.2009, author = {Artmann, Gerhard and Digel, Ilya and Zerlin, Kay and Maggakis-Kelemen, Christina and Linder, Peter and Porst, Dariusz and Kayser, Peter and Stadler, David and Dikta, Gerhard and Temiz Artmann, Ayseg{\"u}l}, title = {Hemoglobin senses body temperature}, series = {European Biophysics Journal}, volume = {38}, journal = {European Biophysics Journal}, number = {5}, isbn = {0175-7571}, pages = {589 -- 600}, year = {2009}, language = {en} } @article{ArtmannGorbatenkovaPanasenko2000, author = {Artmann, Gerhard and Gorbatenkova, E. A. and Panasenko, O. M.}, title = {Hypochlorous acid and human blood low density lipoproteins modified by hypochlorous acid increase erythrocyte adhesion to endothelial cells. Gorbatenkova, E. A.; Artmann, Gerhard Michael; Panasenko, O. M.}, series = {Membrane and cell biology. 13 (2000), H. 4}, journal = {Membrane and cell biology. 13 (2000), H. 4}, isbn = {1023-6597}, pages = {537 -- 546}, year = {2000}, language = {en} } @article{ArtmannGrebeHomrighausenetal.1988, author = {Artmann, Gerhard and Grebe, R. and Homrighausen, A. and Wolff, H. and [u.a.],}, title = {Response of normal and diabetic erythrocytes to membrane deformation by chemical and mechanical forces. Artmann, Gerhard Michael; Grebe, R.; Homrighausen, A.; Wolff, H.; Teitel, P.; Schmid-Sch{\"o}nbein, H.}, series = {12. Jahrestagung der Gesellschaft f{\"u}r Mikrozirkulation}, journal = {12. Jahrestagung der Gesellschaft f{\"u}r Mikrozirkulation}, publisher = {Karger [u.a.]}, address = {Basel [u.a.]}, pages = {196 -- 200}, year = {1988}, language = {en} } @article{ArtmannHovavGoldfarbetal.1999, author = {Artmann, Gerhard and Hovav, T. and Goldfarb, A. and Yedgar, S. [u.a.]}, title = {Enhanced adherence of beta-thalassaemic erythrocytes to endothelial cells. Hovav, T., Goldfarb, A.; Artmann, Gerhard Michael, Yedgar, S.; Barstein, G.}, series = {British Journal of Haematology. 106 (1999), H. 1}, journal = {British Journal of Haematology. 106 (1999), H. 1}, isbn = {1365-2141}, pages = {178 -- 181}, year = {1999}, language = {en} } @article{ArtmannHueckHollwegetal.2000, author = {Artmann, Gerhard and Hueck, I. S. and Hollweg, H. G. and Schmid-Sch{\"o}nbein, G. W.}, title = {Chlorpromazine modulates the Morphological Macro- and Microstructure of Endothelial Cells. Hueck, I. S.; Hollweg, H. G.; Schmid-Sch{\"o}nbein, G. W.; Artmann, Gerhard Michael}, series = {American Journal of Physiology. Cell Physiology. 278 (2000), H. 5}, journal = {American Journal of Physiology. Cell Physiology. 278 (2000), H. 5}, isbn = {1522-1563}, pages = {873 -- 878}, year = {2000}, language = {en} } @article{ArtmannHueckRossiteretal.2008, author = {Artmann, Gerhard and Hueck, Isgard S. and Rossiter, Katharine and Schmid-Sch{\"o}nbein, Geert W.}, title = {Fluid Shear Attenuates Endothelial Pseudopodia Formation into the Capillary Lumen / Hueck, Isgard S. ; Rossiter, Katharine ; Artman, Gerhard M. ; Schmid-Sch{\"o}nbein, Geert W.}, series = {Microcirculation. 15 (2008), H. 6}, journal = {Microcirculation. 15 (2008), H. 6}, isbn = {1549-8719}, pages = {531 -- 542}, year = {2008}, language = {en} } @article{ArtmannKelemenChien2001, author = {Artmann, Gerhard and Kelemen, C. and Chien, S.}, title = {Temperature transition of human hemoglobin at body temperature: effects of calcium. Kelemen, C.; Chien, S.; Artmann, Gerhard Michael}, series = {Biophysical journal. 80 (2001), H. 6}, journal = {Biophysical journal. 80 (2001), H. 6}, isbn = {1542-0086}, pages = {2622 -- 2630}, year = {2001}, language = {en} } @article{ArtmannKelemenPorstetal.1998, author = {Artmann, Gerhard and Kelemen, C. and Porst, Dariusz and B{\"u}ldt, G.}, title = {Cellular engineering: Crash tests an menschlichen Erythrozyten geben Aufschluß {\"u}ber versteckte Materialeigenschaften zellul{\"a}rer Proteine / Artmann, G. M. ; Kelemen, Ch. ; Porst, D. ; B{\"u}ldt, G. ; Chien, Shu}, series = {Biomedizinische Technik / Biomedical Engineering. 43 (1998), H. s1}, journal = {Biomedizinische Technik / Biomedical Engineering. 43 (1998), H. s1}, isbn = {1862-278}, pages = {446 -- 447}, year = {1998}, language = {en} } @article{ArtmannKelemenPorstetal.1998, author = {Artmann, Gerhard and Kelemen, Christina and Porst, Dariusz and B{\"u}ldt, G. [u.a.]}, title = {Temperature transitions of protein properties in human red blood cells. Artmann, Gerhard Michael, Kelemen, Christina; Porst, D.; B{\"u}ldt, G.; Chien, S.}, series = {Biophysical Journal. 75 (1998), H. 6}, journal = {Biophysical Journal. 75 (1998), H. 6}, isbn = {1542-0086}, pages = {3179 -- 3183}, year = {1998}, language = {en} } @article{ArtmannLi1994, author = {Artmann, Gerhard and Li, Anlan}, title = {Dihydroergocryptine maintains erythrocyte fluidity in acidotic and hyperosmolar suspensions modelling hypoxic and ischemic microcirculation. Li, Anlan; Artmann, Gerhard Michael}, series = {Clinical Hemorheology. 15 (1994), H. 2}, journal = {Clinical Hemorheology. 15 (1994), H. 2}, isbn = {0271-5198}, pages = {133 -- 146}, year = {1994}, language = {en} } @article{ArtmannLiSeipeltetal.1999, author = {Artmann, Gerhard and Li, Anlan and Seipelt, H. and M{\"u}ller, C. [u.a.]}, title = {Effects of salicylic acid derivatives on red blood cell membranes. Li, Anlan; Seipelt, H.; M{\"u}ller, C.;Shi, Yong de; Artmann, Gerhard Michael}, series = {Pharmacology and Toxicology. 85 (1999)}, journal = {Pharmacology and Toxicology. 85 (1999)}, isbn = {0902-9938}, pages = {206 -- 211}, year = {1999}, language = {en} } @article{ArtmannLiZiemeretal.1996, author = {Artmann, Gerhard and Li, Anlan and Ziemer, J. and Schneider, G. [u.a.]}, title = {A photometric method to analyze induced erythrocyte shape changes. Artmann, Gerhard Michael; Li, Anlan; Ziemer, J.; Schneider, G.; Sahm, U.: ; Ziemer, J.; Schneider, G.; Sahm, U.}, series = {Biorheology. 33 (1996), H. 3}, journal = {Biorheology. 33 (1996), H. 3}, isbn = {0006-355x}, pages = {251 -- 265}, year = {1996}, language = {en} } @article{ArtmannSchikarsky1993, author = {Artmann, Gerhard and Schikarsky, C.}, title = {Ginkgo Biloba extract (EGb 761) protects red blood cells from oxidative damage. Artmann, Gerhard Michael; Schikarsky, C.}, series = {Clinical Hemorheology. 13 (1993), H. 4}, journal = {Clinical Hemorheology. 13 (1993), H. 4}, isbn = {0271-5198}, pages = {529 -- 539}, year = {1993}, language = {en} } @article{ArtmannSchmidSchoenbein1987, author = {Artmann, Gerhard and Schmid-Sch{\"o}nbein, H.}, title = {The microscope-photometrical-monolayer-technique- a new principle for analyzing the distribution of rheological responses in pathological and experimentally modified red cell populations. Artmann, Gerhard Michael; Schmid-Sch{\"o}nbein, H.}, series = {Microcirculation, an update : proceedings of the Fourth World Congress for Microcirculation, Tokyo, Japan, July 26-30, 1987}, journal = {Microcirculation, an update : proceedings of the Fourth World Congress for Microcirculation, Tokyo, Japan, July 26-30, 1987}, publisher = {Excerpta Medica}, address = {Amsterdam [u.a.]}, isbn = {0444809511}, pages = {475 -- 477}, year = {1987}, language = {en} } @article{ArtmannSchmidSchoenbeinGrebeetal.1988, author = {Artmann, Gerhard and Schmid-Sch{\"o}nbein, H. and Grebe, R. and Teitel, P. [u.a.]}, title = {Restoration of Microsieve Filterability of Human Red Cells After Exposure to Hyperosmolarity and Lactazidosis: Effect of Vinpocetine. Schmid-Sch{\"o}nbein, H.; Grebe, R.; Teitel, P.; Artmann, Gerhard Michael, Eschweiler, H.; Schr{\"o}der, Susanne}, series = {Drug Development Research. 14 (1988), H. 3-4}, journal = {Drug Development Research. 14 (1988), H. 3-4}, isbn = {1098-2299}, pages = {205 -- 211}, year = {1988}, language = {en} } @article{ArtmannSchmidSchoenbeinSchroederetal.1988, author = {Artmann, Gerhard and Schmid-Sch{\"o}nbein, H. and Schr{\"o}der, Susanne and Grebe, R. [u.a.]}, title = {Influence of Moxaverine-HCL on Membrane Curvature and Microsieve Filterability of Red Cells after Exposure to Hyperosmolarity and Lactacidosis. Schmid-Sch{\"o}nbein, H.; Schr{\"o}der, Susanne; Grebe, R.; Artmann, Gerhard Michael, Eschweiler, H; Teitel, P.}, series = {Arzneimittelforschung. 38 (1988), H. 5}, journal = {Arzneimittelforschung. 38 (1988), H. 5}, isbn = {0004-4172}, pages = {710 -- 716}, year = {1988}, language = {en} } @article{ArtmannShiAgostietal.1998, author = {Artmann, Gerhard and Shi, Young de and Agosti, R. and Longhini, E.}, title = {A modified casson equation to characterize blood rheology for hypertension. Shi, Young de; Artmann, Gerhard Michael; Agosti, R.; Longhini, E.}, series = {Clinical Hemorheology Microcirculation. 19 (1998), H. 2}, journal = {Clinical Hemorheology Microcirculation. 19 (1998), H. 2}, isbn = {1386-0291}, pages = {115 -- 127}, year = {1998}, language = {en} } @article{ArtmannSungHornetal.1997, author = {Artmann, Gerhard and Sung, K.-L. Paul and Horn, Thomas and Whittemore, Darren [u.a.]}, title = {Micropipette aspiration of human erythrocytes induces echinocytes via membrane phospholipid translocation. Artmann, Gerhard Michael; Sung, K.-L. Paul; Horn, Thomas; Whittemore, Darren; Norwich, Gerald; Chien, Shu}, series = {Biophysical journal. 72 (1997), H. 3}, journal = {Biophysical journal. 72 (1997), H. 3}, isbn = {1542-0086}, pages = {1434 -- 1441}, year = {1997}, language = {en} } @article{ArtmannTrzewikSchmidSchoenbein2000, author = {Artmann, Gerhard and Trzewik, J. and Schmid-Sch{\"o}nbein, G. W.}, title = {Investigation on lymphatic endothelial microvalves / Trzewik, J. ; Artmann, G. M. ; Schmid-Sch{\"o}nbein, G. W.}, series = {Biomedizinische Technik = Biomedical Engineering. 45 (2000), H. s1}, journal = {Biomedizinische Technik = Biomedical Engineering. 45 (2000), H. s1}, isbn = {1862-278X}, pages = {521 -- 522}, year = {2000}, language = {en} } @article{ArtmannTrzewikAtes2002, author = {Artmann, Gerhard and Trzewik, J{\"u}rgen and Ates, M.}, title = {A novel method to quantify mechanical tension in cell monolayers. Trzewik, J{\"u}rgen; Ates, M., Artmann, Gerhard Michael}, series = {Biomedizinische Technik. 47 (2002), H. Suppl. 1. Pt. 1}, journal = {Biomedizinische Technik. 47 (2002), H. Suppl. 1. Pt. 1}, isbn = {0013-5585}, pages = {379 -- 381}, year = {2002}, language = {en} } @article{ArtmannTrzewikMallipattuetal.2001, author = {Artmann, Gerhard and Trzewik, J{\"u}rgen and Mallipattu, S. K. and Delano, F. A. [u.a.]}, title = {Evidence for a second valve system in Lymphatics: Endothelial Microvalves. Trzewik, J{\"u}rgen; Mallipattu, S. K.; Artmann, Gerhard Michael; Delano, F. A.; Schmid-Schonbein, G. W}, series = {The FASEB Journal. 15 (2001)}, journal = {The FASEB Journal. 15 (2001)}, isbn = {1530-6860}, pages = {1711 -- 1717}, year = {2001}, language = {en} } @article{ArtmannZang1990, author = {Artmann, Gerhard and Zang, Werner}, title = {Fully automatic measurement of rheologic parameters of red blood cells = Laborautomat zur Messung mechanischer Eigenschaften roter Blutzellen}, series = {Biomedizinische Technik = Biomedical engineering. 35 (1990), H. Suppl. 3}, journal = {Biomedizinische Technik = Biomedical engineering. 35 (1990), H. Suppl. 3}, isbn = {0013-5585}, pages = {94 -- 96}, year = {1990}, language = {en} } @article{ArtmannZerlinDigel2008, author = {Artmann, Gerhard and Zerlin, Kay and Digel, Ilya}, title = {Hemoglobin Senses Body Temperature}, series = {Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.)}, journal = {Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.)}, publisher = {Springer}, address = {Berlin}, isbn = {978-3-540-75408-4}, pages = {415 -- 447}, year = {2008}, language = {en} } @article{ArtmannZerlinDigeletal.2007, author = {Artmann, Gerhard and Zerlin, Kay and Digel, Ilya and Stadler, Andreas M.}, title = {Physical discontinuities at body temperature in human red blood cells / Artmann, GM ; Zerlin, K ; Digel, I ; Stadler, A ; Zaccai, G ; Temiz, AA}, series = {Tissue Engineering. 13 (2007), H. 7}, journal = {Tissue Engineering. 13 (2007), H. 7}, isbn = {1076-3279}, pages = {1778 -- 1778}, year = {2007}, language = {en} } @article{ArtmannZhouStacheBuettneretal.2002, author = {Artmann, Gerhard and Zhou-Stache, J. and Buettner, R. and Mittermayer, C. [u.a.]}, title = {Inhibition of TNF-alpha induced cell death in HUVEC and Jurkat cells by protocatechuic acid. Zhou-Stache, J.; Buettner, R.; Artmann, Gerhard Michael; Mittermayer, C.; Bosserhoff, A. K.}, series = {Medical and Biological Engineering and Computing. 40 (2002), H. 6}, journal = {Medical and Biological Engineering and Computing. 40 (2002), H. 6}, isbn = {0140-0118}, pages = {698 -- 703}, year = {2002}, language = {en} } @article{AtlasBrealeyDharetal.2012, author = {Atlas, Glen and Brealey, David and Dhar, Sunil and Dikta, Gerhard and Singer, Meryvn}, title = {Additional hemodynamic measurements with an esophageal Doppler monitor: a preliminary report of compliance, force, kinetic energy, and afterload in the clinical setting}, series = {Journal of clinical monitoring and computing}, journal = {Journal of clinical monitoring and computing}, number = {26}, publisher = {Springer Nature}, address = {London}, isbn = {1573-2614}, doi = {10.1007/s10877-012-9386-5}, pages = {473 -- 482}, year = {2012}, abstract = {The esophageal Doppler monitor (EDM) is a minimally-invasive hemodynamic device which evaluates both cardiac output (CO), and fluid status, by estimating stroke volume (SV) and calculating heart rate (HR). The measurement of these parameters is based upon a continuous and accurate approximation of distal thoracic aortic blood flow. Furthermore, the peak velocity (PV) and mean acceleration (MA), of aortic blood flow at this anatomic location, are also determined by the EDM. The purpose of this preliminary report is to examine additional clinical hemodynamic calculations of: compliance (C), kinetic energy (KE), force (F), and afterload (TSVRi). These data were derived using both velocity-based measurements, provided by the EDM, as well as other contemporaneous physiologic parameters. Data were obtained from anesthetized patients undergoing surgery or who were in a critical care unit. A graphical inspection of these measurements is presented and discussed with respect to each patient's clinical situation. When normalized to each of their initial values, F and KE both consistently demonstrated more discriminative power than either PV or MA. The EDM offers additional applications for hemodynamic monitoring. Further research regarding the accuracy, utility, and limitations of these parameters is therefore indicated.}, language = {en} } @article{AttarMerkKotliaretal.2019, author = {Attar, Mandana Hossein Zadeh and Merk, Hans F. and Kotliar, Konstantin and Wurpts, Gerda and R{\"o}seler, Stefani and Moll-Slodowy, Silke and Plange, Johann and Baron, Jens Malte and Balakirski, Galina}, title = {The CD63 basophil activation test as a diagnostic tool for assessing autoimmunity in patients with chronic spontaneous urticaria}, series = {European Journal of Dermatology}, volume = {29}, journal = {European Journal of Dermatology}, number = {6}, doi = {10.1684/ejd.2019.3680}, pages = {614 -- 618}, year = {2019}, language = {en} } @article{AuffrayBruyndonckxDevroedeetal.2004, author = {Auffray, E. and Bruyndonckx, P. and Devroede, O. and Fedorov, A. and Ziemons, Karl}, title = {The ClearPET project}, series = {Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment}, volume = {527}, journal = {Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment}, number = {1-2}, isbn = {0168-9002}, pages = {171 -- 174}, year = {2004}, abstract = {The Crystal Clear Collaboration has designed and is building a high-resolution small animal PET scanner. The design is based on the use of the Hamamatsu R7600-M64 multi-anode photomultiplier tube and a LSO/LuYAP phoswich matrix with one to one coupling between the crystals and the photo-detector. The complete system will have 80 PM tubes in four rings with an inner diameter of 137 mm and an axial field of view of 110 mm. The PM pulses are digitized by free-running ADCs and digital data processing determines the gamma energy, the phoswich layer and even the pulse arrival time. Single gamma interactions are recorded and coincidences are found by software. The gantry allows rotation of the detector modules around the field of view. Simulations, and measurements a 2×4 module test set-up predict a spatial resolution of 1.5 mm in the centre of the field of view and a sensitivity of 5.9\% for a point source in the centre of the field of view.}, language = {en} } @article{AyalaHarrisKleefeldetal.2023, author = {Ayala, Rafael Ceja and Harris, Isaac and Kleefeld, Andreas and Pallikarakis, Nikolaos}, title = {Analysis of the transmission eigenvalue problem with two conductivity parameters}, series = {Applicable Analysis}, journal = {Applicable Analysis}, publisher = {Taylor \& Francis}, issn = {0003-6811}, doi = {10.1080/00036811.2023.2181167}, pages = {37 Seiten}, year = {2023}, abstract = {In this paper, we provide an analytical study of the transmission eigenvalue problem with two conductivity parameters. We will assume that the underlying physical model is given by the scattering of a plane wave for an isotropic scatterer. In previous studies, this eigenvalue problem was analyzed with one conductive boundary parameter whereas we will consider the case of two parameters. We prove the existence and discreteness of the transmission eigenvalues as well as study the dependence on the physical parameters. We are able to prove monotonicity of the first transmission eigenvalue with respect to the parameters and consider the limiting procedure as the second boundary parameter vanishes. Lastly, we provide extensive numerical experiments to validate the theoretical work.}, language = {en} } @article{AyedKustererFunkeetal.2016, author = {Ayed, Anis Haj and Kusterer, Karsten and Funke, Harald and Keinz, Jan}, title = {CFD Based Improvement of the DLN Hydrogen Micromix Combustion Technology at Increased Energy Densities}, series = {American Scientific Research Journal for Engineering, Technology, and Sciences (ASRJETS)}, volume = {26}, journal = {American Scientific Research Journal for Engineering, Technology, and Sciences (ASRJETS)}, number = {3}, publisher = {GSSRR}, issn = {2313-4402}, pages = {290 -- 303}, year = {2016}, abstract = {Combined with the use of renewable energy sources for its production, Hydrogen represents a possible alternative gas turbine fuel within future low emission power generation. Due to the large difference in the physical properties of Hydrogen compared to other fuels such as natural gas, well established gas turbine combustion systems cannot be directly applied for Dry Low NOx (DLN) Hydrogen combustion. Thus, the development of DLN combustion technologies is an essential and challenging task for the future of Hydrogen fuelled gas turbines. The DLN Micromix combustion principle for hydrogen fuel has been developed to significantly reduce NOx-emissions. This combustion principle is based on cross-flow mixing of air and gaseous hydrogen which reacts in multiple miniaturized diffusion-type flames. The major advantages of this combustion principle are the inherent safety against flash-back and the low NOx-emissions due to a very short residence time of reactants in the flame region of the micro-flames. The Micromix Combustion technology has been already proven experimentally and numerically for pure Hydrogen fuel operation at different energy density levels. The aim of the present study is to analyze the influence of different geometry parameter variations on the flame structure and the NOx emission and to identify the most relevant design parameters, aiming to provide a physical understanding of the Micromix flame sensitivity to the burner design and identify further optimization potential of this innovative combustion technology while increasing its energy density and making it mature enough for real gas turbine application. The study reveals great optimization potential of the Micromix Combustion technology with respect to the DLN characteristics and gives insight into the impact of geometry modifications on flame structure and NOx emission. This allows to further increase the energy density of the Micromix burners and to integrate this technology in industrial gas turbines.}, language = {en} } @article{AyedKustererFunkeetal.2017, author = {Ayed, Anis Haj and Kusterer, Karsten and Funke, Harald and Keinz, Jan and Bohn, D.}, title = {CFD based exploration of the dry-low-NOx hydrogen micromix combustion technology at increased energy densities}, series = {Propulsion and Power Research}, volume = {6}, journal = {Propulsion and Power Research}, number = {1}, publisher = {Elsevier}, address = {Amsterdam}, isbn = {2212-540X}, doi = {10.1016/j.jppr.2017.01.005}, pages = {15 -- 24}, year = {2017}, language = {en} } @article{BaaderBoxbergChenetal.2023, author = {Baader, Fabian and Boxberg, Marc S. and Chen, Qian and F{\"o}rstner, Roger and Kowalski, Julia and Dachwald, Bernd}, title = {Field-test performance of an ice-melting probe in a terrestrial analogue environment}, series = {Icarus}, journal = {Icarus}, number = {409}, publisher = {Elsevier}, address = {Amsterdam}, doi = {10.1016/j.icarus.2023.115852}, pages = {Artikel 115852}, year = {2023}, abstract = {Melting probes are a proven tool for the exploration of thick ice layers and clean sampling of subglacial water on Earth. Their compact size and ease of operation also make them a key technology for the future exploration of icy moons in our Solar System, most prominently Europa and Enceladus. For both mission planning and hardware engineering, metrics such as efficiency and expected performance in terms of achievable speed, power requirements, and necessary heating power have to be known. Theoretical studies aim at describing thermal losses on the one hand, while laboratory experiments and field tests allow an empirical investigation of the true performance on the other hand. To investigate the practical value of a performance model for the operational performance in extraterrestrial environments, we first contrast measured data from terrestrial field tests on temperate and polythermal glaciers with results from basic heat loss models and a melt trajectory model. For this purpose, we propose conventions for the determination of two different efficiencies that can be applied to both measured data and models. One definition of efficiency is related to the melting head only, while the other definition considers the melting probe as a whole. We also present methods to combine several sources of heat loss for probes with a circular cross-section, and to translate the geometry of probes with a non-circular cross-section to analyse them in the same way. The models were selected in a way that minimizes the need to make assumptions about unknown parameters of the probe or the ice environment. The results indicate that currently used models do not yet reliably reproduce the performance of a probe under realistic conditions. Melting velocities and efficiencies are constantly overestimated by 15 to 50 \% in the models, but qualitatively agree with the field test data. Hence, losses are observed, that are not yet covered and quantified by the available loss models. We find that the deviation increases with decreasing ice temperature. We suspect that this mismatch is mainly due to the too restrictive idealization of the probe model and the fact that the probe was not operated in an efficiency-optimized manner during the field tests. With respect to space mission engineering, we find that performance and efficiency models must be used with caution in unknown ice environments, as various ice parameters have a significant effect on the melting process. Some of these are difficult to estimate from afar.}, language = {en} } @article{BalakirskiKotliarPaulyetal.2018, author = {Balakirski, Galina and Kotliar, Konstantin and Pauly, Karolin J. and Krings, Laura K. and R{\"u}bben, Albert and Baron, Jens M. and Schmitt, Laurenz}, title = {Surgical Site Infections After Dermatologic Surgery in Immunocompromised Patients: A Single-Center Experience}, series = {Dermatologic Surgery}, journal = {Dermatologic Surgery}, number = {44 (12)}, publisher = {Wolters Kluwer}, doi = {10.1097/DSS.0000000000001615}, pages = {1525 -- 1536}, year = {2018}, abstract = {BACKGROUND Immunosuppression is often considered as an indication for antibiotic prophylaxis to prevent surgical site infections (SSI) while performing skin surgery. However, the data on the risk of developing SSI after dermatologic surgery in immunosuppressed patients are limited. PATIENTS AND METHODS All patients of the Department of Dermatology and Allergology at the University Hospital of RWTH Aachen in Aachen, Germany, who underwent hospitalization for a dermatologic surgery between June 2016 and January 2017 (6 months), were followed up after surgery until completion of the wound healing process. The follow-up addressed the occurrence of SSI and the need for systemic antibiotics after the operative procedure. Immunocompromised patients were compared with immunocompetent patients. The investigation was conducted as a retrospective analysis of patient records. RESULTS The authors performed 284 dermatologic surgeries in 177 patients. Nineteen percent (54/284) of the skin surgery was performed on immunocompromised patients. The most common indications for surgical treatment were nonmelanoma skin cancer and malignant melanomas. Surgical site infections occurred in 6.7\% (19/284) of the cases. In 95\% (18/19), systemic antibiotic treatment was needed. Twenty-one percent of all SSI (4/19) were seen in immunosuppressed patients. CONCLUSION According to the authors' data, immunosuppression does not represent a significant risk factor for SSI after dermatologic surgery. However, larger prospective studies are needed to make specific recommendations on the use of antibiotic prophylaxis while performing skin surgery in these patients. The available data on complications after dermatologic surgery have improved over the past years. Particularly, additional risk factors have been identified for surgical site infections (SSI). Purulent surgical sites, older age, involvement of head, neck, and acral regions, and also the involvement of less experienced surgeons have been reported to increase the risk of the SSI after dermatologic surgeries.1 In general, the incidence of SSI after skin surgery is considered to be low.1,2 However, antibiotics in dermatologic surgeries, especially in the perioperative setting, seem to be overused,3,4 particularly regarding developing antibiotic resistances and side effects. Immunosuppression has been recommended to be taken into consideration as an additional indication for antibiotic prophylaxis to prevent SSI after skin surgery in special cases.5,6 However, these recommendations do not specify the exact dermatologic surgeries, and were not specifically developed for dermatologic surgery patients and treatments, but adopted from other surgical fields.6 According to the survey conducted on American College of Mohs Surgery members in 2012, 13\% to 29\% of the surgeons administered antibiotic prophylaxis to immunocompromised patients to prevent SSI while performing dermatologic surgery on noninfected skin,3 although this was not recommended by Journal of the American Academy of Dermatology Advisory Statement. Indeed, the data on the risk of developing SSI after dermatologic surgery in immunosuppressed patients are limited. However, it is possible that due to the insufficient evidence on the risk of SSI occurrence in this patient group, dermatologic surgeons tend to overuse perioperative antibiotic prophylaxis. To make specific recommendations on the use of antibiotic prophylaxis in immunosuppressed patients in the field of skin surgery, more information about the incidence of SSI after dermatologic surgery in these patients is needed. The aim of this study was to fill this data gap by investigating whether there is an increased risk of SSI after skin surgery in immunocompromised patients compared with immunocompetent patients.}, language = {en} } @article{BalakrishnanAndreiSelmerSelmeretal.2010, author = {Balakrishnan, Karthikeyan and Andrei-Selmer, Luminita-Cornelia and Selmer, Thorsten and Bacher, Michael and Dodel, Richard}, title = {Comparison of Intravenous Immunoglobulins for Naturally Occurring Autoantibodies against Amyloid-β}, series = {Journal of Alzheimer's Disease}, volume = {20}, journal = {Journal of Alzheimer's Disease}, number = {1}, isbn = {1387-2877}, pages = {135 -- 143}, year = {2010}, language = {en} } @article{BalewskiBrauksiepeHardt1997, author = {Balewski, J. and Brauksiepe, S. and Hardt, Arno}, title = {Threshold measurements at the internal experimental facility COSY-11 / J. Balewski [u.a.]}, series = {Nuclear physics A. Vol. 626, iss. 1-2}, journal = {Nuclear physics A. Vol. 626, iss. 1-2}, issn = {1873-1554 (E-Journal) ; 0375-9474 (Print)}, pages = {85 -- 92}, year = {1997}, language = {en} } @article{BallVoegeleGrajewskietal.2021, author = {Ball, Christopher Stephen and V{\"o}gele, Stefan and Grajewski, Matthias and Kuckshinrichs, Wilhelm}, title = {E-mobility from a multi-actor point of view: Uncertainties and their impacts}, series = {Technological Forecasting and Social Change}, volume = {170}, journal = {Technological Forecasting and Social Change}, number = {Art. 120925}, publisher = {Elsevier}, address = {Amsterdam}, isbn = {0040-1625}, doi = {10.1016/j.techfore.2021.120925}, year = {2021}, language = {en} } @article{BandodkarMolinnusMirzaetal.2014, author = {Bandodkar, Amay J. and Molinnus, Denise and Mirza, Omar and Guinovart, Tomas and Windmiller, Joshua R. and Valdes-Ramirez, Gabriela and Andrade, Francisco J. and Sch{\"o}ning, Michael Josef and Wang, Joseph}, title = {Epidermal tattoo potentiometric sodium sensors with wireless signal transduction for continuous non-invasive sweat monitoring}, series = {Biosensors and bioelectronics}, volume = {54}, journal = {Biosensors and bioelectronics}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1873-4235 (E-Journal); 0956-5663 (Print)}, doi = {10.1016/j.bios.2013.11.039}, pages = {603 -- 609}, year = {2014}, abstract = {This article describes the fabrication, characterization and application of an epidermal temporary-transfer tattoo-based potentiometric sensor, coupled with a miniaturized wearable wireless transceiver, for real-time monitoring of sodium in the human perspiration. Sodium excreted during perspiration is an excellent marker for electrolyte imbalance and provides valuable information regarding an individual's physical and mental wellbeing. The realization of the new skin-worn non-invasive tattoo-like sensing device has been realized by amalgamating several state-of-the-art thick film, laser printing, solid-state potentiometry, fluidics and wireless technologies. The resulting tattoo-based potentiometric sodium sensor displays a rapid near-Nernstian response with negligible carryover effects, and good resiliency against various mechanical deformations experienced by the human epidermis. On-body testing of the tattoo sensor coupled to a wireless transceiver during exercise activity demonstrated its ability to continuously monitor sweat sodium dynamics. The real-time sweat sodium concentration was transmitted wirelessly via a body-worn transceiver from the sodium tattoo sensor to a notebook while the subjects perspired on a stationary cycle. The favorable analytical performance along with the wearable nature of the wireless transceiver makes the new epidermal potentiometric sensing system attractive for continuous monitoring the sodium dynamics in human perspiration during diverse activities relevant to the healthcare, fitness, military, healthcare and skin-care domains.}, language = {en} } @article{BankOrzadaSmitsetal.2015, author = {Bank, Bart L. van de and Orzada, Stephan and Smits, Frits and Lagemaat, Miriam W. and Rodgers, Christopher T. and Bitz, Andreas and Scheenen, Tom W. J.}, title = {Optimized (31) P MRS in the human brain at 7 T with a dedicated RF coil setup}, series = {NMR in Biomedicine}, volume = {28}, journal = {NMR in Biomedicine}, number = {11}, publisher = {Wiley}, address = {Weinheim}, issn = {1099-1492}, doi = {10.1002/nbm.3422}, pages = {1570 -- 1578}, year = {2015}, language = {en} } @article{BansalMuellerVieiraetal.2000, author = {Bansal, N. K. and M{\"u}ller, C. and Vieira, M. E. and Faber, Christian and Schwarzer, Klemens}, title = {Thermal performance of a rock bed storage system}, series = {Proceedings : University of Stuttgart, Germany, August 28th until September 1st, 2000 / Terrastock 2000, 8th International Conference on Thermal Energy Storage. Ed.: M. Benner ... - Vol. 1}, journal = {Proceedings : University of Stuttgart, Germany, August 28th until September 1st, 2000 / Terrastock 2000, 8th International Conference on Thermal Energy Storage. Ed.: M. Benner ... - Vol. 1}, publisher = {Inst. f{\"u}r Thermodynamik und W{\"a}rmetechnik}, address = {Stuttgart}, isbn = {3-9805274-1-7}, pages = {433 -- 439}, year = {2000}, language = {en} } @article{BarbazanHagenbachPaulssenetal.2010, author = {Barbaz{\´a}n, Paula and Hagenbach, Adelheid and Paulßen, Elisabeth and Abram, Ulrich and Carballo, Rosa and Rodriguez-Hermida, Sabina and V{\´a}zquez-L{\´o}pez, Ezequiel M.}, title = {Tricarbonyl Rhenium(I) and Technetium(I) Complexes with Hydrazones Derived from 4,5-Diazafluoren-9-one and 1,10-Phenanthroline-5,6-dione}, series = {European Journal of Inorganic Chemistry}, journal = {European Journal of Inorganic Chemistry}, number = {29}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1099-0682}, doi = {10.1002/ejic.201000522}, pages = {4622 -- 4630}, year = {2010}, abstract = {Tricarbonylrhenium(I) and -technetium(I) halide (halide = Cl and Br) complexes of ligands derived from 4,5-diazafluoren-9-one (df) and 1,10-phenanthroline-5,6-dione (phen) derivatives of benzoic and 2-hydroxybenzoic acid hydrazides have been prepared. The complexes have been characterized by elemental analysis, MS, IR, 1H NMR and absorption and emission UV/Vis spectroscopic methods. The metal centres (ReI and TcI) are coordinated through the nitrogen imine atoms and establish five-membered chelate rings, whereas the hydrazone groups stand uncoordinated. The 1H NMR spectra suggest the same behaviour in solution on the basis of only marginal variations in the chemical shifts of the hydrazine protons.}, language = {en} } @article{BaringhausGaigall2022, author = {Baringhaus, Ludwig and Gaigall, Daniel}, title = {A goodness-of-fit test for the compound Poisson exponential model}, series = {Journal of Multivariate Analysis}, volume = {195}, journal = {Journal of Multivariate Analysis}, number = {Article 105154}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0047-259X}, doi = {10.1016/j.jmva.2022.105154}, year = {2022}, abstract = {On the basis of bivariate data, assumed to be observations of independent copies of a random vector (S,N), we consider testing the hypothesis that the distribution of (S,N) belongs to the parametric class of distributions that arise with the compound Poisson exponential model. Typically, this model is used in stochastic hydrology, with N as the number of raindays, and S as total rainfall amount during a certain time period, or in actuarial science, with N as the number of losses, and S as total loss expenditure during a certain time period. The compound Poisson exponential model is characterized in the way that a specific transform associated with the distribution of (S,N) satisfies a certain differential equation. Mimicking the function part of this equation by substituting the empirical counterparts of the transform we obtain an expression the weighted integral of the square of which is used as test statistic. We deal with two variants of the latter, one of which being invariant under scale transformations of the S-part by fixed positive constants. Critical values are obtained by using a parametric bootstrap procedure. The asymptotic behavior of the tests is discussed. A simulation study demonstrates the performance of the tests in the finite sample case. The procedure is applied to rainfall data and to an actuarial dataset. A multivariate extension is also discussed.}, language = {en} }